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Catálogo Taxonômico da Fauna do Brasil: Setting the baseline knowledge on the animal diversity in Brazil Brasil
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Boeger, Walter A.
; Valim, Michel P.
; Zaher, Hussam
; Rafael, José A.
; Forzza, Rafaela C.
; Percequillo, Alexandre R.
; Serejo, Cristiana S.
; Garraffoni, André R.S.
; Santos, Adalberto J.
; Slipinski, Adam
; Linzmeier, Adelita M.
; Calor, Adolfo R.
; Garda, Adrian A.
; Kury, Adriano B.
; Fernandes, Agatha C.S.
; Agudo-Padrón, Aisur I.
; Akama, Alberto
; Silva Neto, Alberto M. da
; Burbano, Alejandro L.
; Menezes, Aleksandra
; Pereira-Colavite, Alessandre
; Anichtchenko, Alexander
; Lees, Alexander C.
; Bezerra, Alexandra M.R.
; Domahovski, Alexandre C.
; Pimenta, Alexandre D.
; Aleixo, Alexandre L.P.
; Marceniuk, Alexandre P.
; Paula, Alexandre S. de
; Somavilla, Alexandre
; Specht, Alexandre
; Camargo, Alexssandro
; Newton, Alfred F.
; Silva, Aline A.S. da
; Santos, Aline B. dos
; Tassi, Aline D.
; Aragão, Allan C.
; Santos, Allan P.M.
; Migotto, Alvaro E.
; Mendes, Amanda C.
; Cunha, Amanda
; Chagas Júnior, Amazonas
; Sousa, Ana A.T. de
; Pavan, Ana C.
; Almeida, Ana C.S.
; Peronti, Ana L.B.G.
; Henriques-Oliveira, Ana L.
; Prudente, Ana L.
; Tourinho, Ana L.
; Pes, Ana M.O.
; Carmignotto, Ana P.
; Wengrat, Ana P.G. da Silva
; Dornellas, Ana P.S.
; Molin, Anamaria Dal
; Puker, Anderson
; Morandini, André C.
; Ferreira, André da S.
; Martins, André L.
; Esteves, André M.
; Fernandes, André S.
; Roza, André S.
; Köhler, Andreas
; Paladini, Andressa
; Andrade, Andrey J. de
; Pinto, Ângelo P.
; Salles, Anna C. de A.
; Gondim, Anne I.
; Amaral, Antonia C.Z.
; Rondón, Antonio A.A.
; Brescovit, Antonio
; Lofego, Antônio C.
; Marques, Antonio C.
; Macedo, Antonio
; Andriolo, Artur
; Henriques, Augusto L.
; Ferreira Júnior, Augusto L.
; Lima, Aurino F. de
; Barros, Ávyla R. de A.
; Brito, Ayrton do R.
; Romera, Bárbara L.V.
; Vasconcelos, Beatriz M.C. de
; Frable, Benjamin W.
; Santos, Bernardo F.
; Ferraz, Bernardo R.
; Rosa, Brunno B.
; Sampaio, Brunno H.L.
; Bellini, Bruno C.
; Clarkson, Bruno
; Oliveira, Bruno G. de
; Corrêa, Caio C.D.
; Martins, Caleb C.
; Castro-Guedes, Camila F. de
; Souto, Camilla
; Bicho, Carla de L.
; Cunha, Carlo M.
; Barboza, Carlos A. de M.
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; Barreto, Carlos
; Santana, Carlos D.C.M. de
; Agne, Carlos E.Q.
; Mielke, Carlos G.C.
; Caetano, Carlos H.S.
; Flechtmann, Carlos H.W.
; Lamas, Carlos J.E.
; Rocha, Carlos
; Mascarenhas, Carolina S.
; Margaría, Cecilia B.
; Waichert, Cecilia
; Digiani, Celina
; Haddad, Célio F.B.
; Azevedo, Celso O.
; Benetti, Cesar J.
; Santos, Charles M.D. dos
; Bartlett, Charles R.
; Bonvicino, Cibele
; Ribeiro-Costa, Cibele S.
; Santos, Cinthya S.G.
; Justino, Cíntia E.L.
; Canedo, Clarissa
; Bonecker, Claudia C.
; Santos, Cláudia P.
; Carvalho, Claudio J.B. de
; Gonçalves, Clayton C.
; Galvão, Cleber
; Costa, Cleide
; Oliveira, Cléo D.C. de
; Schwertner, Cristiano F.
; Andrade, Cristiano L.
; Pereira, Cristiano M.
; Sampaio, Cristiano
; Dias, Cristina de O.
; Lucena, Daercio A. de A.
; Manfio, Daiara
; Amorim, Dalton de S.
; Queiroz, Dalva L. de
; Queiroz, Dalva L. de
; Colpani, Daniara
; Abbate, Daniel
; Aquino, Daniel A.
; Burckhardt, Daniel
; Cavallari, Daniel C.
; Prado, Daniel de C. Schelesky
; Praciano, Daniel L.
; Basílio, Daniel S.
; Bená, Daniela de C.
; Toledo, Daniela G.P. de
; Takiya, Daniela M.
; Fernandes, Daniell R.R.
; Ament, Danilo C.
; Cordeiro, Danilo P.
; Silva, Darliane E.
; Pollock, Darren A.
; Muniz, David B.
; Gibson, David I.
; Nogueira, David S.
; Marques, Dayse W.A.
; Lucatelli, Débora
; Garcia, Deivys M.A.
; Baêta, Délio
; Ferreira, Denise N.M.
; Rueda-Ramírez, Diana
; Fachin, Diego A.
; Souza, Diego de S.
; Rodrigues, Diego F.
; Pádua, Diego G. de
; Barbosa, Diego N.
; Dolibaina, Diego R.
; Amaral, Diogo C.
; Chandler, Donald S.
; Maccagnan, Douglas H.B.
; Caron, Edilson
; Carvalho, Edrielly
; Adriano, Edson A.
; Abreu Júnior, Edson F. de
; Pereira, Edson H.L.
; Viegas, Eduarda F.G.
; Carneiro, Eduardo
; Colley, Eduardo
; Eizirik, Eduardo
; Santos, Eduardo F. dos
; Shimbori, Eduardo M.
; Suárez-Morales, Eduardo
; Arruda, Eliane P. de
; Chiquito, Elisandra A.
; Lima, Élison F.B.
; Castro, Elizeu B. de
; Orlandin, Elton
; Nascimento, Elynton A. do
; Razzolini, Emanuel
; Gama, Emanuel R.R.
; Araujo, Enilma M. de
; Nishiyama, Eric Y.
; Spiessberger, Erich L.
; Santos, Érika C.L. dos
; Contreras, Eugenia F.
; Galati, Eunice A.B.
; Oliveira Junior, Evaldo C. de
; Gallardo, Fabiana
; Hernandes, Fabio A.
; Lansac-Tôha, Fábio A.
; Pitombo, Fabio B.
; Dario, Fabio Di
; Santos, Fábio L. dos
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; Nascimento, Fabio O. do
; Olmos, Fabio
; Amaral, Fabio R.
; Schunck, Fabio
; Godoi, Fábio S. P. de
; Machado, Fabrizio M.
; Barbo, Fausto E.
; Agrain, Federico A.
; Ribeiro, Felipe B.
; Moreira, Felipe F.F.
; Barbosa, Felipe F.
; Silva, Fenanda S.
; Cavalcanti, Fernanda F.
; Straube, Fernando C.
; Carbayo, Fernando
; Carvalho Filho, Fernando
; Zanella, Fernando C.V.
; Jacinavicius, Fernando de C.
; Farache, Fernando H.A.
; Leivas, Fernando
; Dias, Fernando M.S.
; Mantellato, Fernando
; Vaz-de-Mello, Fernando Z.
; Gudin, Filipe M.
; Albuquerque, Flávio
; Molina, Flavio B.
; Passos, Flávio D.
; Shockley, Floyd W.
; Pinheiro, Francielly F.
; Mello, Francisco de A.G. de
; Nascimento, Francisco E. de L.
; Franco, Francisco L.
; Oliveira, Francisco L. de
; Melo, Francisco T. de V.
; Quijano, Freddy R.B.
; Salles, Frederico F.
; Biffi, Gabriel
; Queiroz, Gabriel C.
; Bizarro, Gabriel L.
; Hrycyna, Gabriela
; Leviski, Gabriela
; Powell, Gareth S.
; Santos, Geane B. dos
; Morse, Geoffrey E.
; Brown, George
; Mattox, George M.T.
; Zimbrão, Geraldo
; Carvalho, Gervásio S.
; Miranda, Gil F.G.
; Moraes, Gilberto J. de
; Lourido, Gilcélia M.
; Neves, Gilmar P.
; Moreira, Gilson R.P.
; Montingelli, Giovanna G.
; Maurício, Giovanni N.
; Marconato, Gláucia
; Lopez, Guilherme E.L.
; Silva, Guilherme L. da
; Muricy, Guilherme
; Brito, Guilherme R.R.
; Garbino, Guilherme S.T.
; Flores, Gustavo E.
; Graciolli, Gustavo
; Libardi, Gustavo S.
; Proctor, Heather C.
; Gil-Santana, Helcio R.
; Varella, Henrique R.
; Escalona, Hermes E.
; Schmitz, Hermes J.
; Rodrigues, Higor D.D.
; Galvão Filho, Hilton de C.
; Quintino, Hingrid Y.S.
; Pinto, Hudson A.
; Rainho, Hugo L.
; Miyahira, Igor C.
; Gonçalves, Igor de S.
; Martins, Inês X.
; Cardoso, Irene A.
; Oliveira, Ismael B. de
; Franz, Ismael
; Fernandes, Itanna O.
; Golfetti, Ivan F.
; S. Campos-Filho, Ivanklin
; Oliveira, Ivo de S.
; Delabie, Jacques H.C.
; Oliveira, Jader de
; Prando, Jadila S.
; Patton, James L.
; Bitencourt, Jamille de A.
; Silva, Janaina M.
; Santos, Jandir C.
; Arruda, Janine O.
; Valderrama, Jefferson S.
; Dalapicolla, Jeronymo
; Oliveira, Jéssica P.
; Hájek, Jiri
; Morselli, João P.
; Narita, João P.
; Martin, João P.I.
; Grazia, Jocélia
; McHugh, Joe
; Cherem, Jorge J.
; Farias Júnior, José A.S.
; Fernandes, Jose A.M.
; Pacheco, José F.
; Birindelli, José L.O.
; Rezende, José M.
; Avendaño, Jose M.
; Duarte, José M. Barbanti
; Ribeiro, José R. Inácio
; Mermudes, José R.M.
; Pujol-Luz, José R.
; Santos, Josenilson R. dos
; Câmara, Josenir T.
; Teixeira, Joyce A.
; Prado, Joyce R. do
; Botero, Juan P.
; Almeida, Julia C.
; Kohler, Julia
; Gonçalves, Julia P.
; Beneti, Julia S.
; Donahue, Julian P.
; Alvim, Juliana
; Almeida, Juliana C.
; Segadilha, Juliana L.
; Wingert, Juliana M.
; Barbosa, Julianna F.
; Ferrer, Juliano
; Santos, Juliano F. dos
; Kuabara, Kamila M.D.
; Nascimento, Karine B.
; Schoeninger, Karine
; Campião, Karla M.
; Soares, Karla
; Zilch, Kássia
; Barão, Kim R.
; Teixeira, Larissa
; Sousa, Laura D. do N.M. de
; Dumas, Leandro L.
; Vieira, Leandro M.
; Azevedo, Leonardo H.G.
; Carvalho, Leonardo S.
; Souza, Leonardo S. de
; Rocha, Leonardo S.G.
; Bernardi, Leopoldo F.O.
; Vieira, Letícia M.
; Johann, Liana
; Salvatierra, Lidianne
; Oliveira, Livia de M.
; Loureiro, Lourdes M.A. El-moor
; Barreto, Luana B.
; Barros, Luana M.
; Lecci, Lucas
; Camargos, Lucas M. de
; Lima, Lucas R.C.
; Almeida, Lucia M.
; Martins, Luciana R.
; Marinoni, Luciane
; Moura, Luciano de A.
; Lima, Luciano
; Naka, Luciano N.
; Miranda, Lucília S.
; Salik, Lucy M.
; Bezerra, Luis E.A.
; Silveira, Luis F.
; Campos, Luiz A.
; Castro, Luiz A.S. de
; Pinho, Luiz C.
; Silveira, Luiz F.L.
; Iniesta, Luiz F.M.
; Tencatt, Luiz F.C.
; Simone, Luiz R.L.
; Malabarba, Luiz R.
; Cruz, Luiza S. da
; Sekerka, Lukas
; Barros, Lurdiana D.
; Santos, Luziany Q.
; Skoracki, Maciej
; Correia, Maira A.
; Uchoa, Manoel A.
; Andrade, Manuella F.G.
; Hermes, Marcel G.
; Miranda, Marcel S.
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; Monné, Marcela L.
; Labruna, Marcelo B.
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; Tavares, Marcelo T.
; Kitahara, Marcelo V.
; Justo, Marcia C.N.
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; Couri, Márcia S.
; Borges-Martins, Márcio
; Felix, Márcio
; Oliveira, Marcio L. de
; Bologna, Marco A.
; Gottschalk, Marco S.
; Tavares, Marcos D.S.
; Lhano, Marcos G.
; Bevilaqua, Marcus
; Santos, Marcus T.T.
; Domingues, Marcus V.
; Sallum, Maria A.M.
; Digiani, María C.
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; Bartz, Marie L.C.
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; Segura, Melissa O.
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; Shibatta, Oscar A.
; Oliveira, Otto M.P.
; Albornoz, Pablo C.L.
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; Shimabukuro, Paloma H.F.
; Grossi, Paschoal
; Rodrigues, Patrícia E. da S.
; Lima, Patricia O.V.
; Velazco, Paul
; Santos, Paula B. dos
; Araújo, Paula B.
; Silva, Paula K.R.
; Riccardi, Paula R.
; Garcia, Paulo C. de A.
; Passos, Paulo G.H.
; Corgosinho, Paulo H.C.
; Lucinda, Paulo
; Costa, Paulo M.S.
; Alves, Paulo P.
; Roth, Paulo R. de O.
; Coelho, Paulo R.S.
; Duarte, Paulo R.M.
; Carvalho, Pedro F. de
; Gnaspini, Pedro
; Souza-Dias, Pedro G.B.
; Linardi, Pedro M.
; Bartholomay, Pedro R.
; Demite, Peterson R.
; Bulirsch, Petr
; Boll, Piter K.
; Pereira, Rachel M.M.
; Silva, Rafael A.P.F.
; Moura, Rafael B. de
; Boldrini, Rafael
; Silva, Rafaela A. da
; Falaschi, Rafaela L.
; Cordeiro, Ralf T.S.
; Mello, Ramon J.C.L.
; Singer, Randal A.
; Querino, Ranyse B.
; Heleodoro, Raphael A.
; Castilho, Raphael de C.
; Constantino, Reginaldo
; Guedes, Reinaldo C.
; Carrenho, Renan
; Gomes, Renata S.
; Gregorin, Renato
; Machado, Renato J.P.
; Bérnils, Renato S.
; Capellari, Renato S.
; Silva, Ricardo B.
; Kawada, Ricardo
; Dias, Ricardo M.
; Siewert, Ricardo
; Brugnera, Ricaro
; Leschen, Richard A.B.
; Constantin, Robert
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; Pinto, Roberta R.
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; Marques, Rodrigo C.
; Araújo, Rodrigo C.
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; Johnsson, Rodrigo
; Feitosa, Rodrigo M.
; Hutchings, Roger W.
; Lara, Rogéria I.R.
; Rossi, Rogério V.
; Gerstmeier, Roland
; Ochoa, Ronald
; Hutchings, Rosa S.G.
; Ale-Rocha, Rosaly
; Rocha, Rosana M. da
; Tidon, Rosana
; Brito, Rosangela
; Pellens, Roseli
; Santos, Sabrina R. dos
; Santos, Sandra D. dos
; Paiva, Sandra V.
; Santos, Sandro
; Oliveira, Sarah S. de
; Costa, Sávio C.
; Gardner, Scott L.
; Leal, Sebastián A. Muñoz
; Aloquio, Sergio
; Bonecker, Sergio L.C.
; Bueno, Sergio L. de S.
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; Stampar, Sérgio N.
; Andena, Sérgio R.
; Posso, Sergio R.
; Lima, Sheila P.
; Gadelha, Sian de S.
; Thiengo, Silvana C.
; Cohen, Simone C.
; Brandão, Simone N.
; Rosa, Simone P.
; Ribeiro, Síria L.B.
; Letana, Sócrates D.
; Santos, Sonia B. dos
; Andrade, Sonia C.S.
; Dávila, Stephane
; Vaz, Stéphanie
; Peck, Stewart B.
; Christo, Susete W.
; Cunha, Suzan B.Z.
; Gomes, Suzete R.
; Duarte, Tácio
; Madeira-Ott, Taís
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; Maria, Tatiana F.
; Ruschel, Tatiana P.
; Rodrigues, Thaiana
; Marinho, Thais A.
; Almeida, Thaís M. de
; Miranda, Thaís P.
; Freitas, Thales R.O.
; Pereira, Thalles P.L.
; Zacca, Thamara
; Pacheco, Thaynara L.
; Martins, Thiago F.
; Alvarenga, Thiago M.
; Carvalho, Thiago R. de
; Polizei, Thiago T.S.
; McElrath, Thomas C.
; Henry, Thomas
; Pikart, Tiago G.
; Porto, Tiago J.
; Krolow, Tiago K.
; Carvalho, Tiago P.
; Lotufo, Tito M. da C.
; Caramaschi, Ulisses
; Pinheiro, Ulisses dos S.
; Pardiñas, Ulyses F.J.
; Maia, Valéria C.
; Tavares, Valeria
; Costa, Valmir A.
; Amaral, Vanessa S. do
; Silva, Vera C.
; Wolff, Vera R. dos S.
; Slobodian, Verônica
; Silva, Vinícius B. da
; Espíndola, Vinicius C.
; Costa-Silva, Vinicius da
; Bertaco, Vinicius de A.
; Padula, Vinícius
; Ferreira, Vinicius S.
; Silva, Vitor C.P. da
; Piacentini, Vítor de Q.
; Sandoval-Gómez, Vivian E.
; Trevine, Vivian
; Sousa, Viviane R.
; Sant’Anna, Vivianne B. de
; Mathis, Wayne N.
; Souza, Wesley de O.
; Colombo, Wesley D.
; Tomaszewska, Wioletta
; Wosiacki, Wolmar B.
; Ovando, Ximena M.C.
; Leite, Yuri L.R.
.
ABSTRACT The limited temporal completeness and taxonomic accuracy of species lists, made available in a traditional manner in scientific publications, has always represented a problem. These lists are invariably limited to a few taxonomic groups and do not represent up-to-date knowledge of all species and classifications. In this context, the Brazilian megadiverse fauna is no exception, and the Catálogo Taxonômico da Fauna do Brasil (CTFB) (http://fauna.jbrj.gov.br/), made public in 2015, represents a database on biodiversity anchored on a list of valid and expertly recognized scientific names of animals in Brazil. The CTFB is updated in near real time by a team of more than 800 specialists. By January 1, 2024, the CTFB compiled 133,691 nominal species, with 125,138 that were considered valid. Most of the valid species were arthropods (82.3%, with more than 102,000 species) and chordates (7.69%, with over 11,000 species). These taxa were followed by a cluster composed of Mollusca (3,567 species), Platyhelminthes (2,292 species), Annelida (1,833 species), and Nematoda (1,447 species). All remaining groups had less than 1,000 species reported in Brazil, with Cnidaria (831 species), Porifera (628 species), Rotifera (606 species), and Bryozoa (520 species) representing those with more than 500 species. Analysis of the CTFB database can facilitate and direct efforts towards the discovery of new species in Brazil, but it is also fundamental in providing the best available list of valid nominal species to users, including those in science, health, conservation efforts, and any initiative involving animals. The importance of the CTFB is evidenced by the elevated number of citations in the scientific literature in diverse areas of biology, law, anthropology, education, forensic science, and veterinary science, among others. publications problem uptodate up date classifications context exception (CTFB http//fauna.jbrj.gov.br/, httpfaunajbrjgovbr http //fauna.jbrj.gov.br/ , jbrj gov br (http://fauna.jbrj.gov.br/) 2015 Brazil 80 specialists 1 2024 133691 133 691 133,69 125138 125 138 125,13 82.3%, 823 82 3 (82.3% 102000 102 000 102,00 7.69%, 769 7 69 (7.69% 11000 11 11,00 . 3,567 3567 567 (3,56 2,292 2292 2 292 (2,29 1,833 1833 833 (1,83 1,447 1447 447 (1,44 1000 1,00 831 (83 628 (62 606 (60 520 (52 50 users science health biology law anthropology education others http//fauna.jbrj.gov.br/ faunajbrjgovbr //fauna.jbrj.gov.br (http://fauna.jbrj.gov.br/ 201 8 202 13369 13 133,6 12513 12 125,1 82.3% (82.3 10200 10 00 102,0 7.69% 76 6 (7.69 1100 11,0 3,56 356 56 (3,5 2,29 229 29 (2,2 1,83 183 83 (1,8 1,44 144 44 (1,4 100 1,0 (8 62 (6 60 52 (5 5 http//fauna.jbrj.gov.br (http://fauna.jbrj.gov.br 20 1336 133, 1251 125, 82.3 (82. 1020 0 102, 7.69 (7.6 110 11, 3,5 35 (3, 2,2 22 (2, 1,8 18 (1, 1,4 14 4 ( 82. (82 7.6 (7. 3, (3 2, (2 (1 7. (7
2.
Rapid detection of Phaeocytostroma sacchari in sugarcane using conventional polymerase chain reaction
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Melo, Jordana Alves da Silva
; Abreu, Vanessa Pereira de
; Teles, Thiago Augusto Sampaio
; Cunha, Marcos Gomes da
.
ABSTRACT Diseases caused by fungi associated with adverse weather conditions are one of the main causes of decreases in sugarcane production. This study aimed to develop a protocol for a fast identification of Phaeocytostroma sacchari, which is the causal agent of bark rot in sugarcane. The reference sequences of three DNA regions of P. sacchari, namely internal transcribed spacer, ribosomal large subunit and translation elongation factor 1-alpha (TEFl-α), were analyzed with specific primers design. The specific primers generated that aligned in their entirety with P. sacchari were selected and synthesized. Polymerase chain reaction (PCR) assays were performed to confirm the primer specificity, using P. sacchari isolates and 10 species of other genera. Two sets of primers that amplify the TEF-1α region (PsFl/Psfl and PsF2/PsR2) showed a high specificity and sensitivity in detecting P. sacchari using conventional PCR, what will allow large-scale surveys of this pathogen in sugarcane crops. production P spacer 1alpha alpha 1 TEFlα, TEFlα TEFl α , (TEFl-α) design synthesized PCR (PCR genera TEF1α TEFα TEF 1α PsFl/Psfl PsFlPsfl PsFl Psfl PsF2/PsR2 PsF2PsR2 PsFPsR PsF2 PsR2 PsF PsR largescale scale crops (TEFl-α PsF2/PsR PsF2PsR
RESUMO Doenças causadas por fungos associadas a condições climáticas adversas são uma das principais causas da queda na produção de cana-de-açúcar. Objetivou-se desenvolver um protocolo para identificação rápida de Phaeocytostroma sacchari, agente causal da podridão da casca de cana-de-açúcar. Sequências de referência de três regiões de DNA de P. sacchari, sendo região espaçadora transcrita interna, grande subunidade ribossômica e fator de elongação da tradução 1-alfa (TEFl-α), foram analisadas por meio de desenhos de primers específicos. Os primers gerados que se alinharam em sua totalidade com P. sacchari foram selecionados e sintetizados. Ensaios baseados na reação em cadeia de polimerase (PCR) foram realizados para verificar a especificidade do primer, utilizando-se isolados de P. sacchari e 10 espécies de outros gêneros. Dois conjuntos de primers que amplificam a região TEF-la (PsFl/Psfl e PsF2/PsR2) demonstraram alta especificidade e sensibilidade na detecção de P. sacchari com PCR convencional, o que permitirá o levantamento em larga escala do patógeno na cultura de cana-de-açúcar. canadeaçúcar. canadeaçúcar cana açúcar. açúcar cana-de-açúcar Objetivouse Objetivou P interna 1alfa alfa 1 TEFlα, TEFlα TEFl α , (TEFl-α) específicos sintetizados (PCR primer utilizandose utilizando gêneros TEFla TEF la PsFl/Psfl PsFlPsfl PsFl Psfl PsF2/PsR2 PsF2PsR2 PsFPsR PsF2 PsR2 PsF PsR convencional (TEFl-α PsF2/PsR PsF2PsR
3.
High PD-L1 expression is associated with unfavorable clinical features in myelodysplastic neoplasms PDL1 PDL PD L1 L PD-L
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Sampaio, Leticia Rodrigues
; Viana, Mateus de Aguiar
; Oliveira, Vanessa Silva de
; Ferreira, Bruna Vitoriano
; Melo, Mayara Magna Lima
; Oliveira, Roberta Taiane Germano de
; Borges, Daniela de Paula
; Magalhãesa, Silvia Maria Meira
; Pinheiro, Ronald F.
.
ABSTRACT Introduction: Immune checkpoints are regulators of the immune system response that allow self-tolerance. Molecules such as Programmed Cell Death Protein 1 (PD-1) and its Ligand (PD-L1) participate in the immune checkpoint by signaling co-inhibition of lymphocyte responses. In cancers, PD-L1 expression is associated with the immune evasion mechanism, which favors tumor growth. The use of anti-PD-1/PD-L1 drugs is already well described in solid tumors, but still not fully understood in hematologic malignancies. Myelodysplastic neoplasms (MDSs) are heterogeneous bone marrow disorders with an increased risk of progression to Acute Myeloid Leukemia (AML). The MDS affects hematopoietic stem cells and its pathogenesis is linked to genetic and epigenetic defects, in addition to immune dysregulation. The influence of the PD-L1 on the MDS remains unknown. Methods: In this study, we evaluated the mRNA expression of the PD-L1 in 53 patients with MDS, classified according to the WHO 2016 Classification. Results: Patients with dyserythropoiesis presented significantly higher PD-L1 expression than patients without dyserythropoiesis (p = 0.050). Patients classified as having MDS with an excess of blasts 2 (MDS-EB2) presented a significant upregulation in the mRNA expression of the PD-L1 compared to the MDS with an excess of blasts 1 (MDS-EB1) (p = 0.050). Furthermore, we detected three patients with very high levels of PD-L1 expression, being statistically classified as outliers. Conclusion: We suggested that the high expression of the PD-L1 is associated with a worse prognosis in the MDS and functional studies are necessary to evaluate the possible use of anti-PD-L1 therapies for high-risk MDS, such as the MDS-EBs. Introduction selftolerance. selftolerance self tolerance. tolerance self-tolerance PD1 PD (PD-1 PDL1 PDL L1 L (PD-L1 coinhibition co inhibition responses cancers PD-L mechanism growth antiPD1/PDL1 antiPD1PDL1 antiPDPDL anti 1/PD anti-PD-1/PD-L tumors malignancies MDSs (MDSs AML. AML . (AML) defects dysregulation unknown Methods study 5 201 Classification Results p 0.050. 0050 0.050 0 050 0.050) MDSEB2 MDSEB EB2 EB (MDS-EB2 MDSEB1 EB1 (MDS-EB1 Furthermore outliers Conclusion antiPDL1 antiPDL anti-PD-L highrisk MDSEBs. MDSEBs EBs. EBs MDS-EBs (PD- (PD-L antiPD1 antiPD antiPD1/PDL antiPD1PDL 1PD (AML 20 005 0.05 05 (MDS-EB (PD 00 0.0 0.
4.
Effect of melatonin on otoprotection in rodents: a systematic review with meta-analysis rodents metaanalysis meta analysis
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Assumpção, Natália Lombardi
; Araújo, Juliana Gusmão de
; Serra, Lucieny Silva Martins
; Ribeiro, Vanessa Veis
; Sampaio, Maria Luiza Queiroz
; Caram, Andressa Alves
; Sampaio, André Luiz Lopes
.
Abstract Objectives: To determinate the otoprotective efficacy of melatonin.in experimental models of rodents through a systematic review of the literature. Methods: Altogether, 154 articles were found in four databases. The PICOS strategy (Population, Intervention, Comparison, and Outcome) was used to define the eligibility criteria. Studies that met the inclusion criteria for the second step were included in a qualitative synthesis. Each study type was analyzed with the CAMARADES quality of assessment’s checklist and the SYRCLE RoBS risk of bias. Results: Seven articles were selected, and four were included in the meta-analysis. It was possible to obtain seven outcomes according to the standard auditory frequencies presented among the studies, considering a minimum of three standard frequencies. The outcomes analyzed were for the frequencies of 1500, 2000, 3000, 4000, 5000, 6000, and 8000 Hz. Conclusion: Melatonin can provide protection against the ototoxic effects of cisplatin and aminoglycosides at 5000 Hz, 6000 Hz, and 8000 Hz, thereby minimizing the reduction in Otoacustic Emissions (OAE) amplitude. The same effect was not observed in the lower frequencies. Despite the limited number of studies that were evaluated, the results appeared consistent in higher frequencies. However, the methodology of the available studies did not meet the necessary methodological rigor that promotes the safe replicability of these studies. Objectives melatoninin melatonin literature Methods Altogether 15 databases Population, Population (Population Intervention Comparison Outcome synthesis assessments assessment s bias Results selected metaanalysis. metaanalysis meta analysis. analysis meta-analysis 1500 2000 3000 4000 800 Hz Conclusion 500 600 OAE (OAE amplitude evaluated However 1 150 200 300 400 80 50 60 20 30 40 8 5 6 2 3 4
5.
IMPACTO-MR: um estudo brasileiro de plataforma nacional para avaliar infecções e multirresistência em unidades de terapia intensiva IMPACTOMR IMPACTO MR IMPACTO-MR
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Tomazini, Bruno M
; Nassar Jr, Antonio Paulo
; Lisboa, Thiago Costa
; Azevedo, Luciano César Pontes de
; Veiga, Viviane Cordeiro
; Catarino, Daniela Ghidetti Mangas
; Fogazzi, Debora Vacaro
; Arns, Beatriz
; Piastrelli, Filipe Teixeira
; Dietrich, Camila
; Negrelli, Karina Leal
; Jesuíno, Isabella de Andrade
; Reis, Luiz Fernando Lima
; Mattos, Renata Rodrigues de
; Pinheiro, Carla Cristina Gomes
; Luz, Mariane Nascimento
; Spadoni, Clayse Carla da Silva
; Moro, Elisângela Emilene
; Bueno, Flávia Regina
; Sampaio, Camila Santana Justo Cintra
; Silva, Débora Patrício
; Baldassare, Franca Pellison
; Silva, Ana Cecilia Alcantara
; Veiga, Thabata
; Barbante, Leticia
; Lambauer, Marianne
; Campos, Viviane Bezerra
; Santos, Elton
; Santos, Renato Hideo Nakawaga
; Laranjeiras, Ligia Nasi
; Valeis, Nanci
; Santucci, Eliana
; Miranda, Tamiris Abait
; Patrocínio, Ana Cristina Lagoeiro do
; Carvalho, Andréa de
; Sousa, Eduvirgens Maria Couto de
; Sousa, Ancelmo Honorato Ferraz de
; Malheiro, Daniel Tavares
; Bezerra, Isabella Lott
; Rodrigues, Mirian Batista
; Malicia, Julliana Chicuta
; Silva, Sabrina Souza da
; Gimenes, Bruna dos Passos
; Sesin, Guilhermo Prates
; Zavascki, Alexandre Prehn
; Sganzerla, Daniel
; Medeiros, Gregory Saraiva
; Santos, Rosa da Rosa Minho dos
; Silva, Fernanda Kelly Romeiro
; Cheno, Maysa Yukari
; Abrahão, Carolinne Ferreira
; Oliveira Junior, Haliton Alves de
; Rocha, Leonardo Lima
; Nunes Neto, Pedro Aniceto
; Pereira, Valéria Chagas
; Paciência, Luis Eduardo Miranda
; Bueno, Elaine Silva
; Caser, Eliana Bernadete
; Ribeiro, Larissa Zuqui
; Fernandes, Caio Cesar Ferreira
; Garcia, Juliana Mazzei
; Silva, Vanildes de Fátima Fernandes
; Santos, Alisson Junior dos
; Machado, Flávia Ribeiro
; Souza, Maria Aparecida de
; Ferronato, Bianca Ramos
; Urbano, Hugo Corrêa de Andrade
; Moreira, Danielle Conceição Aparecida
; Souza-Dantas, Vicente Cés de
; Duarte, Diego Meireles
; Coelho, Juliana
; Figueiredo, Rodrigo Cruvinel
; Foreque, Fernanda
; Romano, Thiago Gomes
; Cubos, Daniel
; Spirale, Vladimir Miguel
; Nogueira, Roberta Schiavon
; Maia, Israel Silva
; Zandonai, Cassio Luis
; Lovato, Wilson José
; Cerantola, Rodrigo Barbosa
; Toledo, Tatiana Gozzi Pancev
; Tomba, Pablo Oscar
; Almeida, Joyce Ramos de
; Sanches, Luciana Coelho
; Pierini, Leticia
; Cunha, Mariana
; Sousa, Michelle Tereza
; Azevedo, Bruna
; Dal-Pizzol, Felipe
; Damasio, Danusa de Castro
; Bainy, Marina Peres
; Beduhn, Dagoberta Alves Vieira
; Jatobá, Joana D’Arc Vila Nova
; Moura, Maria Tereza Farias de
; Rego, Leila Rezegue de Moraes
; Silva, Adria Vanessa da
; Oliveira, Luana Pontes
; Sodré Filho, Eliene Sá
; Santos, Silvana Soares dos
; Neves, Itallo de Lima
; Leão, Vanessa Cristina de Aquino
; Paes, João Lucidio Lobato
; Silva, Marielle Cristina Mendes
; Oliveira, Cláudio Dornas de
; Santiago, Raquel Caldeira Brant
; Paranhos, Jorge Luiz da Rocha
; Wiermann, Iany Grinezia da Silva
; Pedroso, Durval Ferreira Fonseca
; Sawada, Priscilla Yoshiko
; Prestes, Rejane Martins
; Nascimento, Glícia Cardoso
; Grion, Cintia Magalhães Carvalho
; Carrilho, Claudia Maria Dantas de Maio
; Dantas, Roberta Lacerda Almeida de Miranda
; Silva, Eliane Pereira
; Silva, Antônio Carlos da
; Oliveira, Sheila Mara Bezerra de
; Golin, Nicole Alberti
; Tregnago, Rogerio
; Lima, Valéria Paes
; Silva, Kamilla Grasielle Nunes da
; Boschi, Emerson
; Buffon, Viviane
; Machado, André Sant’Ana
; Capeletti, Leticia
; Foernges, Rafael Botelho
; Carvalho, Andréia Schubert de
; Oliveira Junior, Lúcio Couto de
; Oliveira, Daniela Cunha de
; Silva, Everton Macêdo
; Ribeiro, Julival
; Pereira, Francielle Constantino
; Salgado, Fernanda Borges
; Deutschendorf, Caroline
; Silva, Cristofer Farias da
; Gobatto, Andre Luiz Nunes
; Oliveira, Carolaine Bomfim de
; Dracoulakis, Marianna Deway Andrade
; Alvaia, Natália Oliveira Santos
; Souza, Roberta Machado de
; Araújo, Larissa Liz Cardoso de
; Melo, Rodrigo Morel Vieira de
; Passos, Luiz Carlos Santana
; Vidal, Claudia Fernanda de Lacerda
; Rodrigues, Fernanda Lopes de Albuquerque
; Kurtz, Pedro
; Shinotsuka, Cássia Righy
; Tavares, Maria Brandão
; Santana, Igor das Virgens
; Gavinho, Luciana Macedo da Silva
; Nascimento, Alaís Brito
; Pereira, Adriano J
; Cavalcanti, Alexandre Biasi
.
RESUMO Objetivo: Descrever o IMPACTO-MR, um estudo brasileiro de plataforma nacional em unidades de terapia intensiva focado no impacto das infecções por bactérias multirresistentes relacionadas à assistência à saúde. Métodos: Descrevemos a plataforma IMPACTO-MR, seu desenvolvimento, critérios para seleção das unidades de terapia intensiva, caracterização da coleta de dados, objetivos e projetos de pesquisa futuros a serem realizados na plataforma. Resultados: Os dados principais foram coletados por meio do Epimed Monitor System® e consistiram em dados demográficos, dados de comorbidades, estado funcional, escores clínicos, diagnóstico de internação e diagnósticos secundários, dados laboratoriais, clínicos e microbiológicos e suporte de órgãos durante a internação na unidade de terapia intensiva, entre outros. De outubro de 2019 a dezembro de 2020, 33.983 pacientes de 51 unidades de terapia intensiva foram incluídos no banco de dados principal. Conclusão: A plataforma IMPACTO-MR é um banco de dados clínico brasileiro de unidades de terapia intensiva focado na pesquisa do impacto das infecções por bactérias multirresistentes relacionadas à assistência à saúde. Essa plataforma fornece dados para o desenvolvimento e pesquisa de unidades de terapia intensiva individuais e ensaios clínicos observacionais e prospectivos multicêntricos. Objetivo IMPACTOMR, IMPACTOMR IMPACTO MR, MR saúde Métodos Resultados System demográficos comorbidades funcional secundários laboratoriais outros 201 2020 33983 33 983 33.98 5 principal Conclusão multicêntricos 20 202 3398 3 98 33.9 2 339 9 33.
ABSTRACT Objective: To describe the IMPACTO-MR, a Brazilian nationwide intensive care unit platform study focused on the impact of health care-associated infections due to multidrug-resistant bacteria. Methods: We described the IMPACTO-MR platform, its development, criteria for intensive care unit selection, characterization of core data collection, objectives, and future research projects to be held within the platform. Results: The core data were collected using the Epimed Monitor System® and consisted of demographic data, comorbidity data, functional status, clinical scores, admission diagnosis and secondary diagnoses, laboratory, clinical, and microbiological data, and organ support during intensive care unit stay, among others. From October 2019 to December 2020, 33,983 patients from 51 intensive care units were included in the core database. Conclusion: The IMPACTO-MR platform is a nationwide Brazilian intensive care unit clinical database focused on researching the impact of health care-associated infections due to multidrug-resistant bacteria. This platform provides data for individual intensive care unit development and research and multicenter observational and prospective trials. Objective IMPACTOMR, IMPACTOMR IMPACTO MR, MR careassociated associated multidrugresistant multidrug resistant bacteria Methods selection collection objectives Results System status scores diagnoses laboratory stay others 201 2020 33983 33 983 33,98 5 Conclusion trials 20 202 3398 3 98 33,9 2 339 9 33,
6.
Evaluating the psychometric properties of the eHealth Literacy Scale in Brazilian adults
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Mialhe, Fábio Luiz
; Moraes, Katarinne Lima
; Sampaio, Helena Alves de Carvalho
; Brasil, Virgínia Visconde
; Vila, Vanessa da Silva Carvalho
; Soares, Gustavo Hermes
; Rebustini, Flávio
.
RESUMO Objetivo: Traduzir e adaptar a eHealth Literacy Scale para a realidade cultural do Brasil e avaliar suas propriedades psicométricas da versão em português brasileiro. Métodos: O instrumento foi traduzido e adaptado ao português brasileiro e, em seguida, aplicado em uma amostra de 502 indivíduos entre 18 e 80 anos residentes em áreas circunvizinhas a seis Unidades de Saúde da Família de um município do interior do estado de São Paulo, Brasil. Os dados foram avaliados mediante análises fatorial exploratória e confirmatória, Teoria de Resposta ao Item e confiabilidade do instrumento (alfa de Cronbach e ômega de McDonald). Resultados: O instrumento eHealth Literacy Scale - versão brasileira (eHEALS-Br) apresentou excelente consistência interna (α = 0,95 e ω = 0,95), apenas uma dimensão e variância explicada de 81,79%. Conclusões: A versão brasileira do instrumento mostrou excelentes propriedades psicométricas para aferição dos níveis de letramento digital em saúde em adultos do nosso país.
ABSTRACT Objective: To translate and adapt the eHealth Literacy Scale for the cultural reality of Brazil and to evaluate the psychometric properties of its Brazilian Portuguese version. Methods: The instrument was translated and adapted to Brazilian Portuguese and applied to a sample of 502 individuals from 18 to 80 years old who lived in the surrounding areas of six Family Health Units of a city in the countryside of the state of São Paulo, Brazil. The data was evaluated using exploratory and confirmatory factor analysis, item response theory, and instrument reliability measures (Cronbach’s alpha and McDonald’s omega). Results: The eHealth Literacy Scale - Brazilian version (eHEALS-Br) presented an excellent internal consistency (α = 0.95 e ω = 0.95), with only one dimension and an explained variation of 81.79%. Conclusions: The Brazilian version of the instrument showed excellent psychometric properties to measure the levels of digital health literacy in adults from the country.
RESUMEN Objetivo: Traducir y adaptar la eHealth Literacy Scale a realidad cultural Brasileña y evaluar sus propiedades psicométricas de la versión en portugués brasileño. Métodos: El instrumento fue traducido y adaptado al portugués brasileño y, en seguida, aplicado en una muestra de 502 individuos entre 18 y 80 años residentes en áreas cercas a seis Unidades de Salud de la Familia de un municipio del interior del estado de São Paulo, Brasil. Los datos fueron evaluados mediante análisis factorial exploratoria y confirmatoria, Teoría de Respuesta al Ítem y confiabilidad del instrumento (alfa de Cronbach y omega de McDonald). Resultados: El instrumento eHealth Literacy Scale - versión brasileña (eHEALS-Br) presentó excelente consistencia interna (α = 0,95 y ω = 0,95), apenas una dimensión y variancia explicada de 81,79%. Conclusiones: La versión brasileña del instrumento mostró excelentes propiedades psicométricas para contraste de los niveles de alfabetización digital en salud en adultos del nuestro país.
https://doi.org/10.1590/0034-7167-2020-1320
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7.
Perspectiva do paciente sobre a assistência à saúde no contexto da Covid-19
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Rodrigues, Juliana Loureiro da Silva Queiroz
; Villar, Vanessa Cristina Felippe Lopes
; Duarte, Sabrina da Costa Machado
; Corrêa, Claudia Dolores Trierweiler Sampaio de Oliveira
; Reis, Erika Cardoso dos
; Janotti, Letícia
.
RESUMO Trata-se de um estudo transversal, descritivo e analítico com abordagem qualitativa, que ob- jetivou discutir a perspectiva do paciente sobre a assistência à saúde para Covid-19 no estado do Rio de Janeiro. Participaram 160 pacientes com sintomas e/ou diagnóstico de Covid-19 que procuram assistência à saúde no estado. Os dados foram coletados por meio de um questionário eletrônico autoaplicável no período de julho a outubro de 2020, sendo a amostra caracterizada com auxílio do software SPSS versão 26; e os dados referentes à perspectiva dos pacientes sobre a assistência à saúde, submetidos à análise temática de conteúdo. Dentre os resultados, emergiram três categorias: Satisfação do paciente sobre a assistência à saúde; Perspectivas do paciente diante das condutas e práticas clínicas no atendimento à saúde; Sentimentos expressados pelo paciente ante o atendimento à saúde, sintomas e diagnóstico para a Covid-19. Destacou-se a ausência de apoio e suporte emocional para o paciente, além de déficits dos recursos humanos, materiais e estrutura, interferindo no gerenciamento do cuidado de saúde. Considera- se que compreender a perspectiva dos pacientes atendidos nos serviços de saúde poderá contribuir para a melhoria da qualidade do atendimento nos serviços de saúde.
ABSTRACT This is a cross-sectional, descriptive and analytical study with a qualitative approach, with the aim to discuss the patient’s perspective on health care to Covid-19 in the state of Rio de Janeiro. The participants were 160 patients with Covid-19 symptoms and/or diagnosis that looked for health care in the state of Rio de Janeiro. The data were collected through a self-applicable electronic questionnaire from July to October 2020, with its sampling being characterized with the SPSS version 26 software support, and the patient’s perspective on health care data submitted to content thematic analysis. Three categories emerged among the results: Patient’s satisfaction with health care; Patient’s perspectives facing health care conducts and clinical practices; Patient’s feelings expressed while facing Covid-19 regarding the care received, symptoms, and diagnosis. It was highlighted the absence of emotional support to the patient, besides human resources, structure and material deficits, which interfere in health care management. It must be taken into consideration that understanding the patient’s perspective in health services can contribute to the quality improvement of health care.
8.
Perspectiva do paciente sobre a assistência à saúde no contexto da Covid-19
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Rodrigues, Juliana Loureiro da Silva Queiroz
; Villar, Vanessa Cristina Felippe Lopes
; Duarte, Sabrina da Costa Machado
; Corrêa, Claudia Dolores Trierweiler Sampaio de Oliveira
; Reis, Erika Cardoso dos
; Janotti, Letícia
.
RESUMO Trata-se de um estudo transversal, descritivo e analítico com abordagem qualitativa, que ob- jetivou discutir a perspectiva do paciente sobre a assistência à saúde para Covid-19 no estado do Rio de Janeiro. Participaram 160 pacientes com sintomas e/ou diagnóstico de Covid-19 que procuram assistência à saúde no estado. Os dados foram coletados por meio de um questionário eletrônico autoaplicável no período de julho a outubro de 2020, sendo a amostra caracterizada com auxílio do software SPSS versão 26; e os dados referentes à perspectiva dos pacientes sobre a assistência à saúde, submetidos à análise temática de conteúdo. Dentre os resultados, emergiram três categorias: Satisfação do paciente sobre a assistência à saúde; Perspectivas do paciente diante das condutas e práticas clínicas no atendimento à saúde; Sentimentos expressados pelo paciente ante o atendimento à saúde, sintomas e diagnóstico para a Covid-19. Destacou-se a ausência de apoio e suporte emocional para o paciente, além de déficits dos recursos humanos, materiais e estrutura, interferindo no gerenciamento do cuidado de saúde. Considera- se que compreender a perspectiva dos pacientes atendidos nos serviços de saúde poderá contribuir para a melhoria da qualidade do atendimento nos serviços de saúde.
ABSTRACT This is a cross-sectional, descriptive and analytical study with a qualitative approach, with the aim to discuss the patient’s perspective on health care to Covid-19 in the state of Rio de Janeiro. The participants were 160 patients with Covid-19 symptoms and/or diagnosis that looked for health care in the state of Rio de Janeiro. The data were collected through a self-applicable electronic questionnaire from July to October 2020, with its sampling being characterized with the SPSS version 26 software support, and the patient’s perspective on health care data submitted to content thematic analysis. Three categories emerged among the results: Patient’s satisfaction with health care; Patient’s perspectives facing health care conducts and clinical practices; Patient’s feelings expressed while facing Covid-19 regarding the care received, symptoms, and diagnosis. It was highlighted the absence of emotional support to the patient, besides human resources, structure and material deficits, which interfere in health care management. It must be taken into consideration that understanding the patient’s perspective in health services can contribute to the quality improvement of health care.
9.
Fermented beverage obtained from soy and rice incorporated with inulin and oligosaccharides derived from succinoglycan
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NASCIMENTO, Marília Gimenez
; SOUZA, Hâmara Milaneze de
; DELANI, Tieles Carina de Oliveira
; CROZATTI, Thamara Thaiane da Silva
; MARCOLINO, Vanessa Aparecida
; RUIZ, Suelen Pereira
; SAMPAIO, Anderson Reginaldo
; MIYOSHI, Juliana Harumi
; MATIOLI, Graciette
.
Abstract The aim of this study was to evaluate the effect of incorporating inulin and oligosaccharides resulted from the enzymatic hydrolysis of the commercial succinoglycan, regarding the physicochemical properties, rheology, syneresis and probiotic viability of soy and rice-based fermented beverages added with Lactobacillus paracasei. Four formulations were prepared and supplemented with 3.5% of inulin; 0.5% of succinoglycan oligosaccharides; 3.0% of inulin and 0.5% of succinoglycan oligosaccharides, and evaluated for 28 days of storage under refrigeration at 5 ºC. The succinoglycan oligosaccharides presented an average degree of polymerization (DPn) of 8. All the formulations were characterized as pseudoplastic fluids. Regarding syneresis, the formulations with succinoglycan oligosaccharides and Mix exhibited a reduction of it and this was not observed in the formulation with inulin. Regarding the probiotic viability, all the formulations maintained the subsistence of Lactobacillus paracasei with counts above 108 CFU mL-1 up to the 28th storage day, however, only the incorporated prebiotic formulations presented sufficient numbers of viable cells after exposure to simulated gastrointestinal conditions. Therefore, this fermented beverage proved to be an innovative alternative of non-dairy products interesting for the food industry to attend the population’s aspirations for functional products.
10.
Long-term Impact of Adenotonsillectomy on the Quality of Life of Children with Sleep-disordered breathing
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Caixeta, Juliana Alves Sousa
; Sampaio, Jessica Caixeta Silva
; Costa, Vanessa Vaz
; Silveira, Isadora Milhomem Bruno da
; Oliveira, Carolina Ribeiro Fernandes de
; Caixeta, Luiz Claudio Alves Sousa
; Avelino, Melissa Ameloti Gomes
.
International Archives of Otorhinolaryngology
- Journal Metrics
Abstract Introduction Adenotonsillectomy is the first-line treatment for obstructive sleep apnea secondary to adenotonsillar hypertrophy in children. The physical benefits of this surgery are well known as well as its impact on the quality of life (QoL), mainly according to short-term evaluations. However, the long-term effects of this surgery are still unclear. Objective To evaluate the long-term impact of adenotonsillectomy on the QoL of children with sleep-disordered breathing (SDB). Method This was a prospective non-controlled study. Children between 3 and 13 years of age with symptoms of SDB for whom adenotonsillectomy had been indicated were included. Children with comorbities were excluded. Quality of life was evaluated using the obstructive sleep apnea questionnaire (OSA-18), which was completed prior to, 10 days, 6 months, 12 months and, at least, 18 months after the procedure. For statistical analysis, p-values lower than 0.05 were defined as statistically significant. Results A total of 31 patients were enrolled in the study. The average age was 5.2 years, and 16 patients were male. The OSA-18 scores improved after the procedure in all domains, and this result was maintained until the last evaluation, done 22 ± 3 months after the procedure. Improvement in each domain was not superior to achieved in other domains. No correlation was found between tonsil or adenoid size and OSA-18 scores. Conclusion This is the largest prospective study that evaluated the long-term effects of the surgery on the QoL of children with SDB using the OSA-18. Our results show adenotonsillectomy has a positive impact in children's QoL.
https://doi.org/10.1055/s-0040-1709195
139 downloads
11.
Atualização da Diretriz de Ressuscitação Cardiopulmonar e Cuidados Cardiovasculares de Emergência da Sociedade Brasileira de Cardiologia - 2019
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Bernoche, Claudia
; Timerman, Sergio
; Polastri, Thatiane Facholi
; Giannetti, Natali Schiavo
; Siqueira, Adailson Wagner da Silva
; Piscopo, Agnaldo
; Soeiro, Alexandre de Matos
; Reis, Amélia Gorete Afonso da Costa
; Tanaka, Ana Cristina Sayuri
; Thomaz, Ana Maria
; Quilici, Ana Paula
; Catarino, Andrei Hilário
; Ribeiro, Anna Christina de Lima
; Barreto, Antonio Carlos Pereira
; Azevedo Filho, Antonio Fernando Barros de
; Pazin Filho, Antonio
; Timerman, Ari
; Scarpa, Bruna Romanelli
; Timerman, Bruno
; Tavares, Caio de Assis Moura
; Martins, Cantidio Soares Lemos
; Serrano Junior, Carlos Vicente
; Malaque, Ceila Maria Sant’Ana
; Pisani, Cristiano Faria
; Batista, Daniel Valente
; Leandro, Daniela Luana Fernandes
; Szpilman, David
; Gonçalves, Diego Manoel
; Paiva, Edison Ferreira de
; Osawa, Eduardo Atsushi
; Lima, Eduardo Gomes
; Adam, Eduardo Leal
; Peixoto, Elaine
; Evaristo, Eli Faria
; Azeka, Estela
; Silva, Fabio Bruno da
; Wen, Fan Hui
; Ferreira, Fatima Gil
; Lima, Felipe Gallego
; Fernandes, Felipe Lourenço
; Ganem, Fernando
; Galas, Filomena Regina Barbosa Gomes
; Tarasoutchi, Flavio
; Souza, Germano Emilio Conceição
; Feitosa Filho, Gilson Soares
; Foronda, Gustavo
; Guimarães, Helio Penna
; Abud, Isabela Cristina Kirnew
; Leite, Ivanhoé Stuart Lima
; Linhares Filho, Jaime Paula Pessoa
; Moraes Junior, João Batista de Moura Xavier
; Falcão, João Luiz Alencar de Araripe
; Ramires, Jose Antônio Franchini
; Cavalini, José Fernando
; Saraiva, José Francisco Kerr
; Abrão, Karen Cristine
; Pinto, Lecio Figueira
; Bianchi, Leonardo Luís Torres
; Lopes, Leonardo Nícolau Geisler Daud
; Piegas, Leopoldo Soares
; Kopel, Liliane
; Godoy, Lucas Colombo
; Tobase, Lucia
; Hajjar, Ludhmila Abrahão
; Dallan, Luís Augusto Palma
; Caneo, Luiz Fernando
; Cardoso, Luiz Francisco
; Canesin, Manoel Fernandes
; Park, Marcelo
; Rabelo, Marcia Maria Noya
; Malachias, Marcus Vinícius Bolívar
; Gonçalves, Maria Aparecida Batistão
; Almeida, Maria Fernanda Branco de
; Souza, Maria Francilene Silva
; Favarato, Maria Helena Sampaio
; Carrion, Maria Julia Machline
; Gonzalez, Maria Margarita
; Bortolotto, Maria Rita de Figueiredo Lemos
; Macatrão-Costa, Milena Frota
; Shimoda, Mônica Satsuki
; Oliveira-Junior, Mucio Tavares de
; Ikari, Nana Miura
; Dutra, Oscar Pereira
; Berwanger, Otávio
; Pinheiro, Patricia Ana Paiva Corrêa
; Reis, Patrícia Feitosa Frota dos
; Cellia, Pedro Henrique Moraes
; Santos Filho, Raul Dias dos
; Gianotto-Oliveira, Renan
; Kalil Filho, Roberto
; Guinsburg, Ruth
; Managini, Sandrigo
; Lage, Silvia Helena Gelas
; Yeu, So Pei
; Franchi, Sonia Meiken
; Shimoda-Sakano, Tania
; Accorsi, Tarso Duenhas
; Leal, Tatiana de Carvalho Andreucci
; Guimarães, Vanessa
; Sallai, Vanessa Santos
; Ávila, Walkiria Samuel
; Sako, Yara Kimiko
.
https://doi.org/10.5935/abc.20190203
54793 downloads
12.
STUDY OF ALPHA-AMYLASE OBTAINED BY SOLID STATE FERMENTATION OF CASSAVA RESIDUE IN AQUEOUS TWO-PHASE SYSTEMS
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Pereira, Adejanildo da Silva
; Fontan, Rafael Ilhéu da Costa
; Franco, Marcelo
; Souza Júnior, Evaldo Cardozo de
; Veloso, Cristiane Martins
; Sampaio, Vanessa Santos
; Bonomo, Paulo
; Bonomo, Renata Cristina Ferreira
.
Brazilian Journal of Chemical Engineering
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Abstract The α-amylase enzyme was produced by solid state fermentation (SSF) and its partition behavior in Aqueous Two-Phase Systems (ATPS) was determined using systems consisting of polyethylene glycol (PEG) and potassium phosphate buffer. To determine the best conditions for α-amylase production, a central composite design was constructed for two independent variables: fermentation time and moisture content, and for the partition study, a face-centered central composite design (CCF) with four independent variables: PEG molecular weight, pH, temperature and partition time. It was indicated that the best enzyme production conditions were a fermentation time of 35.0 hours and 45.7% moisture content. From the results obtained, it was found that increasing the polymer molecular weight promotes a reduction of the enzyme concentration in the upper phase, increasing its concentration in the lower phase. It was also observed that the partition coefficients increased with increasing pH values and a reduction in temperature.
https://doi.org/10.1590/0104-6632.20180353s20170003
1741 downloads
13.
Melhoria do valor nutricional do brownie utilizando farinha do mesocarpo externo do pequi (Caryocar brasiliense camb)
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Reis Filho, Jadas
; Lustosa, Iramaia Bruno Silva
; Sampaio, Rafaella Maria Monteiro
; Moreira, Marta da Rocha
; Morais, Vanessa Duarte de
; Sousa, Verlaine Suênia Silva de
.
O principal objetivo desse trabalho foi desenvolver um brownie com a farinha do mesocarpo externo do pequi para substituições na farinha de trigo e com isso, melhorar o valor nutricional do produto. A obtenção da farinha foi realizada com as cascas depois de tratadas e fatiadas, expostas ao sol, quando estavam quebradiças, foram transformadas em farinha, essa foi utilizada em uma receita de padrão de brownie e realizada substituições parciais na farinha de trigo. Foi feita uma análise sensorial para identificar a sua aceitação. Com os resultados foram feitos testes estatísticos (ANOVA e teste de Tukey). A interpretação química dos brownies foram realizadas por análise já realizada da farinha da casca do pequi e pela utilização da tabela brasileira de composição dos alimentos para os demais ingredientes do brownie. As amostras controle, 12,5% e 25% obtiveram melhor aceitação e intenção de compra, houve melhora nutricional de todas as amostras e diminuição dos custos da receita, com acréscimo da farinha da casca do pequi. Concluímos que a utilização da farinha da casca do pequi é viável para receitas culinárias, aumentando o valor nutricional e diminuindo os custos.
The objective of this study was to develop a brownie with the flour from external mesocarp of pequi as a substitute for wheat flour, to improve the nutritional value of the product. The flour was obtained with the peels after being treated and sliced, exposed to the sun, when they were brittle, and then transformed into flour. This was used in a standard brownie recipe and it was performed partial substitutions in wheat flour. A sensory analysis was performed to identify the acceptance. The results were statistically analysed with one-way factor analysis and Tukey's test. The chemical interpretation of the brownies was carried out by a previous analysis of the pequi peel flour and the use of the brazilian table of food composition for the other brownie ingredients. The samples control, 12.5% and 25% obtained better acceptance and purchase intention, there was nutritional improvement of all the samples and reduction costs of the recipe with addition of pequi peel flour. We conclude that the use of pequi peel flour is feasible for culinary recipes, increasing nutritional value and lowering costs.
713 downloads
14.
Acute kidney injury complicating bee stings – a review
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Silva Junior, Geraldo Bezerra da
; Vasconcelos Junior, Adolfo Gomes
; Rocha, Amanda Maria Timbó
; Vasconcelos, Vanessa Ribeiro de
; Barros Neto, João de
; Fujishima, Julye Sampaio
; Ferreira, Nathália Barros
; Barros, Elvino José Guardão
; Daher, Elizabeth De Francesco
.
Revista do Instituto de Medicina Tropical de São Paulo
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ABSTRACT Bee stings can cause severe reactions and have caused many victims in the last years. Allergic reactions can be triggered by a single sting and the greater the number of stings, the worse the prognosis. The poisoning effects can be systemic and can eventually cause death. The poison components are melitin, apamin, peptide 401, phospholipase A2, hyaluronidase, histamine, dopamine, and norepinephrine, with melitin being the main lethal component. Acute kidney injury (AKI) can be observed in patients suffering from bee stings and this is due to multiple factors, such as intravascular hemolysis, rhabdomyolysis, hypotension and direct toxicity of the venom components to the renal tubules. Arterial hypotension plays an important role in this type of AKI, leading to ischemic renal lesion. The most commonly identified biopsy finding in these cases is acute tubular necrosis, which can occur due to both, ischemic injury and the nephrotoxicity of venom components. Hemolysis and rhabdomyolysis reported in many cases in the literature, were demonstrated by elevated serum levels of indirect bilirubin and creatine kinase. The severity of AKI seems to be associated with the number of stings, since creatinine levels were higher, in most cases, when there were more than 1,000 stings. The aim of this study is to present an updated review of AKI associated with bee stings, including the currently advised clinical approach.
https://doi.org/10.1590/s1678-9946201759025
4184 downloads
15.
Fatores associados à infecção pelo HIV/AIDS entre adolescentes e adultos jovens matriculados em Centro de Testagem e Aconselhamento no Estado da Bahia, Brasil
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Pereira, Bianca de Souza
; Costa, Maria Conceição Oliveira
; Amaral, Magali Teresópolis Reis
; Costa, Hervânia Santana da
; Silva, Carlos Alberto Lima da
; Sampaio, Vanessa Silva
.
O estudo procura investigar fatores associados à infecção pelo HIV entre adolescentes e adultos jovens, registrados no Centro de Testagem e Aconselhamento/CTA de Feira de Santana, Bahia. Estudo analítico com delineamento transversal, utilizando dados do Sistema de Informação do CTA (SI-CTA) no período de 2007 a 2011. Foram processadas informações de 3.768 indivíduos, sendo verificada a diferença de proporções, com Qui-quadrado de Pearson e análise estratificada, através da Razão de Prevalência/RP, com Intervalos de Confiança de 95%, considerando como desfecho o status sorológico. No período estudado, 73 jovens estavam infectados pelo HIV (1,94%). Na população feminina, foram identificadas associações, estatisticamente significantes, para soropositividade e consumo de drogas, consumo de bebidas alcoólicas e outras drogas; estar casada ou em união estável. No sexo masculino, associaram-se com a soropositividade o consumo de outras drogas e orientação homossexual/bissexual. Em ambos os sexos, na categoria com parceiro estável, a soropositividade mostrou associação com companheiro usuário de drogas e/ou portador de DST e/ou HIV. Esses achados sinalizam a necessidade de medidas eficazes no controle e prevenção da infecção pelo HIV, entre jovens.
The study seeks to investigate factors associated with HIV infection among adolescents and young adults registered in the Counseling and Testing Center (CTC) of Feira de Santana, Bahia. An analytical study with a cross-sectional design was conducted using data from the CTC Information System in the period from 2007 to 2011. Information on 3,768 individuals were studied and the proportional difference was checked using the Pearson chi-squared test and stratified analysis by Prevalence Rate (PR) with confidence intervals of 95%, considering the serological status as the outcome. During the period under study, 73 young people were infected with HIV (1.94%). In the female population, statistically significant associations were identified for HIV status and drug use and consumption of alcohol and other drugs, as well as being married or in a stable relationship. In males, the consumption of other drugs and homosexual/bisexual orientation were associated with HIV status. In both sexes, in the category in a stable relationship the HIV status was associated with a partner using drugs and/or infected with a STD and/or HIV. These findings indicate the need for effective measures for the control and prevention of HIV infection among young people.
https://doi.org/10.1590/1413-81232014193.16042013
12916 downloads
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