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Abstract: Introduction: COVID-19 has caused many deaths on the planet. To date we do not know its long-term impact. Conversion of hospital centers and home reclusion impacted those with a disease. Currently, the presence of pain has been identified as a chronic complication of COVID-19. Objective: To document the impact of COVID-19 on patients with pain and its chronicity. Material and methods: Literature search in the PubMed database for documents that contained the words «COVID», «SARS-CoV», «Pain» in the title. No meta-analyses were identified. We found systematized and documentary reviews on which we based our information. Conclusions: COVID-19 presents chronic pain as a long-term manifestation. It is advisable to generate lines of research aimed at documenting this phenomenon.

Resumen: Introducción: La COVID-19 ha causado muchas muertes en el planeta. A la fecha desconocemos su impacto a largo plazo. La conversión de los centros hospitalarios y el resguardo domiciliario impactaron la atención de los enfermos. Actualmente se ha identificado la presencia de dolor como complicación crónica. Objetivo: Documentar el impacto de la COVID-19 en enfermos con dolor y su cronicidad. Material y métodos: Búsqueda de la literatura en la base de datos PubMed de documentos que en el título presentaran las palabras «COVID», «SARS-CoV», «Pain». No se identificaron metaanálisis. Encontramos revisiones sistematizadas y documentales en las que basamos la información presentada. Conclusiones: La COVID-19 presenta dolor crónico como una manifestación a largo plazo. Es conveniente que se generen líneas de investigación tendientes a documentar este fenómeno.

https://doi.org/10.35366/115318

La crisis de opioides en México
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Covarrubias-Gómez, Alfredo

; Esquer-Guzmán, Héctor M

; Carrillo-Torres, Orlando

; Carmona-Rodríguez, José L

; Ramos-Guerrero, Jorge A

; Soto-Pérez de Celis, Enrique

; García-Andreu, Jorge

; Vega-Blancas, Juan L

; Gutiérrez-Salmerón, Claudia

Revista mexicana de anestesiología

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sep 2023, Volume 46 N. 3 Pages 161 - 165

Abstract: Es | Text: Es | PDF: Es

https://doi.org/10.35366/111069

Safety and Revisit Related to Discharge the Sixty-one Spanish Emergency Department Medical Centers Without Hospitalization in Patients with COVID-19 Pneumonia. A Prospective Cohort Study UMC-Pneumonia COVID-19
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Jacob, Javier

; Albert-Casado, Arantxa

; Castillo, Juan G. Del

; Llorens-Soriano, Pere

; Jiménez-Hernández, Sonia

; Burillo-Putze, Guillermo

; Martín-Martínez, Alfonso

; Martín-Sánchez, Francisco J.

; García-Lamberechts, Eric J.

; Piñera-Salmerón, Pascual

; Alquézar-Arbé, Aitor

; Ferre-Losa, Carles

; Juan-Gómez, María Á.

; Serrano-Lázaro, Leticia

; Noceda-Bermejo, José

; Salido-Mota, Manuel

; Fortuny-Bayarri, María J.

; González-Tejera, Matilde

; Ferreras-Amez, José M.

; Díaz-Fernández, Elena

; Quero-Motto, Eva

; Peiró-Gómez, Ana

; Martín-Mojarro, Enrique

; Llopis-Roca, Ferran

; Huerta-García, Arturo

; Pedraza-García, Jorge

; Meléndez-Cálix, Napoleón

; Brazó-Aznar, José V.

; Cano-Cano, María J.

; Miró, Óscar

Revista de investigación clínica

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jun 2022, Volume 74 N. 3 Pages 135 - 146

Abstract: En | Text: En | PDF: En

ABSTRACT Background: Information is needed on the safety and efficacy of direct discharge from the emergency department (ED) of patients with COVID-19 pneumonia. Objectives: The objectives of the study were to study the variables associated with discharge from the ED in patients presenting with COVID-19 pneumonia, and study ED revisits related to COVID-19 at 30 days (EDR30d). Methods: Multicenter study of the SIESTA cohort including 1198 randomly selected COVID patients in 61 EDs of Spanish medical centers from March 1, 2020, to April 30, 2020. We collected baseline and related characteristics of the acute episode and calculated the adjusted odds ratios (aOR) for ED discharge. In addition, we analyzed the variables related to EDR30d in discharged patients. Results: We analyzed 859 patients presenting with COVID-19 pneumonia, 84 (9.8%) of whom were discharged from the ED. The variables independently associated with discharge were being a woman (aOR 1.890; 95%CI 1.176-3.037), age < 60 years (aOR 2.324; 95%CI 1.353-3.990), and lymphocyte count > 1200/mm3 (aOR 4.667; 95%CI 1.045-20.839). The EDR30d of the ED discharged group was 40.0%, being lower in women (aOR 0.368; 95%CI 0.142-0.953). A total of 130 hospitalized patients died (16.8%) as did two in the group discharged from the ED (2.4%) (OR 0.121; 95%CI 0.029-0.498). Conclusion: Discharge from the ED in patients with COVID-19 pneumonia was infrequent and was associated with few variables of the episode. The EDR30d was high, albeit with a low mortality.

https://doi.org/10.24875/ric.22000021 8 downloads

Violencia de pareja y depresión en mujeres que trabajan en una institución de salud de México
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Guzmán-Rodríguez, Cecilia

; Cupul-Uicab, Lea A

; Guimarães Borges, Guilherme L

; Salazar-Martínez, Eduardo

; Salmerón, Jorge

; Reynales-Shigematsu, Luz M

Gaceta Sanitaria

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apr 2021, Volume 35 N. 2 Pages 161 - 167

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Abstract Objective To assess the effect of intimate partner violence on the risk of depression and depressive symptoms among adult women. Method We analyzed data from the Mexican Health Workers' Cohort study (n=470). Type and severity of intimate partner violence was ascertained between 2004 and 2011. Self-reported medical diagnosis of depression (2011) was the main outcome; depressive symptoms ascertained with the Centre for Epidemiologic Studies-Depression (CES-D) scale was the secondary outcome. Random-effects regressions were run to model the risk of depression (logistic) and depressive symptoms (linear) in relation to intimate partner violence. Results 41.9% women experienced intimate partner violence at baseline. The incidence of depression was 7.2%. The risk of depression increased with any type of IPV (adjusted odds ratio [aOR]=2.9; 95% confidence interval [95%CI]: 1.4-6.2) and with physical (aOR=4.3; 95%CI: 1.8-10.1), psychological (aOR=3.1; 95%CI: 1.4-6.6) and sexual (aOR=3.1; 95%CI: 1.2-8.2) violence. Depressive symptoms (CES-D) increased slightly with physical and sexual intimate partner violence. Conclusions Intimate partner violence was associated with a higher risk of depression in this sample of women working in a Mexican health facility. Our results indicate the need to develop infrastructure, to implement strategies of attention and counselling, and to provide a safe environment in the workplace for women who experience intimate partner violence.

Resumen Objetivo Evaluar el efecto de la violencia de pareja, experimentada en los últimos 12 meses, sobre el riesgo de depresión y la sintomatología depresiva en mujeres adultas. Método Se analizaron los datos de 470 mujeres de la Cohorte de Trabajadores de la Salud de México. El tipo y la gravedad de la violencia de pareja se midieron en los años 2004 y 2011. El evento principal fue el diagnóstico médico de depresión (2011). Un evento secundario fue la sintomatología depresiva (2004 y 2011), evaluada mediante la Escala de Depresión del Centro de Estudios Epidemiológicos (CES-D). El riesgo de depresión y la sintomatología depresiva en relación con la violencia se evaluaron con modelos de regresión de efectos aleatorios logísticos y lineales, respectivamente. Resultados El 41,9% experimentó violencia de pareja en la medición basal. La incidencia de depresión fue del 7,2%. El riesgo de depresión aumentó con la violencia de pareja de cualquier tipo (odds ratio ajustada [ORa]=2,9; intervalo de confianza del 95% [IC95%]: 1,4-6,2) y con las violencias física (ORa=4,3; IC95%: 1,8-10,1), psicológica (ORa=3,1; IC95%: 1,4-6,6) y sexual (ORa=3,1; IC95%: 1,2--8,2). Los síntomas depresivos (CES-D) aumentaron ligeramente con las violencias física y sexual. Conclusiones La violencia de pareja se asoció a un mayor riesgo de depresión en mujeres trabajadoras de una institución de salud de México. Los resultados indican la necesidad de contar con infraestructura, implementar estrategias de atención y consejería, y brindar un ambiente seguro en los lugares de trabajo para quienes sufren violencia de pareja.

https://doi.org/10.1016/j.gaceta.2019.09.005

Violencia de pareja y depresión en mujeres que trabajan en una institución de salud de México
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Guzmán-Rodríguez, Cecilia

; Cupul-Uicab, Lea A

; Guimarães Borges, Guilherme L

; Salazar-Martínez, Eduardo

; Salmerón, Jorge

; Reynales-Shigematsu, Luz M

Gaceta Sanitaria

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apr 2021, Volume 35 N. 2 Pages 161 - 167

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

https://doi.org/10.1016/j.gaceta.2019.09.005

Predictores de la función renal en una cohorte de adultos mexicanos
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Torrescano-de Labra, Elva L

; Cupul-Uicab, Lea A

; Ramírez-Palacios, Paula

; Salmerón, Jorge

; Muñoz-Aguirre, Carmen P

; Salazar-Martínez, Eduardo

Salud Pública de México

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apr 2020, Volume 62 N. 2 Pages 156 - 165

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Abstract: Objectives: Our aim was to examine prospectively predictors of subclinical renal alterations among adults without chronic kidney disease. Materials and methods: We analyzed data from a cohort of Mexican adults (n=757). Kidney function (2010) was assessed with the estimated glomerular filtration rate (eGFR-Cr), serum creatinine and uric acid. Predictors of each kidney function marker (2004) were identified with linear and logistic regression models. Results: 33% had an eGFR-Cr <90 ml/min/1.73 m2. eGFR-Cr was lower among men, those >40 years old and users of antihypertensive medication; and higher among those with a high protein intake. Serum creatinine predictors were similar to those observed for eGFR-Cr. Uric acid decreased in men, among those with obesity, hypertension and high cholesterol. Conclusion: Conventional kidney function biomarkers are useful to identify subclinical alterations. Some predictors of kidney function are potentially modifiable, therefore susceptible for intervention among high-risk groups.

Resumen: Objetivo: Examinar prospectivamente los predictores de alteraciones subclínicas de la función renal en adultos sin diagnóstico previo de enfermedad renal crónica. Material y métodos: Se analizaron datos de una cohorte de adultos mexicanos (n=757). La función renal (2010) se midió mediante la tasa de filtración glomerular estimada (TFGE-Cr), creatinina y ácido úrico séricos. Los predictores (2004) se identificaron con modelos de regresión lineal y logística. Resultados: Se clasificó 33% con TFGE-Cr disminuida. La TFGE-Cr fue menor en hombres, en >40 años y en usuarios de antihipertensivos; y fue mayor en aquellos con consumo proteico alto. Los predictores de la creatinina fueron similares a los de la TFGE-Cr. El ácido úrico disminuyó en participantes hombres, con obesidad, hipertensión e hipercolesterolemia. Conclusión. Los biomarcadores séricos convencionales son útiles para identificar alteraciones subclínicas de la función renal. Algunos predictores de la función renal son potencialmente modificables, por tanto susceptibles de intervención.

https://doi.org/10.21149/10615 7 downloads

Predictores de la función renal en una cohorte de adultos mexicanos
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Torrescano-de Labra, Elva L

; Cupul-Uicab, Lea A

; Ramírez-Palacios, Paula

; Salmerón, Jorge

; Muñoz-Aguirre, Carmen P

; Salazar-Martínez, Eduardo

Salud Pública de México

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apr 2020, Volume 62 N. 2 Pages 156 - 165

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

https://doi.org/10.21149/10615

La educación con un sitio multimedia en combinación con la terapia nutricia mejora el estilo de vida y la HbA1c en diabetes mellitus tipo 2. Estudio clínico cuasiexperimental
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PENNEY-AMADOR, CARLOS

; MENDOZA-SALMERÓN, GRECIA

; MUÑOZ-TORRES, ABRIL VIOLETA

; ROY-GARCÍA, IVONNE

; ACHAR-DE LA MACORRA, RENATA

; LAM-CHAVEZ, ANA ELISA

; ESCOBEDO-DE LA PEÑA, JORGE

; VELÁZQUEZ-LÓPEZ, LUBIA

Revista médica de Chile

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apr 2020, Volume 148 N. 4 Pages 478 - 481

Abstract: Es | Text: Es | PDF: Es

Background Education is the mainstay of medical management of chronic non communicable diseases such as diabetes mellitus. Aim To assess the effects of a multimedia diabetes education intervention and nutritional therapy on lifestyle changes and metabolic control of patients with type 2 diabetes mellitus. Material and Methods We studied 219 patients with type 2 diabetes mellitus aged 56 ± 8 years (28% males). They received education through a multimedia site about control indicators, complications, nutrition and physical exercise, among others. They also received a personalized nutritional therapy. They were followed-up for one year. At baseline and the end of follow up they were weighed, and their waist circumference and blood pressure were measured. A fasting blood sample was withdrawn to measure glucose, glycosylated hemoglobin and lipid profile. Lifestyles were assessed using a self-administered questionnaire called IMEVID. Results The median duration of diabetes was six years. During the follow up, patients had a significant reduction in body weight, waist circumference and blood pressure and improvements in glycosylated hemoglobin, HDL and LDL cholesterol. Seven and 13% of patients reported favorable lifestyles at baseline and the end of follow up, respectively (p < 0.01). Compared with their counterparts with unfavorable lifestyles, patients with a favorable lifestyle had a significantly lower weight and glycosylated hemoglobin at the end of follow up. Conclusions The educational intervention along with nutritional therapy improved metabolic control and lifestyles in this group of diabetic patients.

https://doi.org/10.4067/s0034-98872020000400478 2194 downloads

Protocolo de manejo para la infección por COVID-19
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Pérez Nieto, Orlando Rubén

; Zamarrón López, Eder Iván

; Guerrero Gutiérrez, Manuel Alberto

; Soriano Orozco, Raúl

; Figueroa Uribe, Augusto Flavio

; López Fermín, Jorge

; Osorio Ruíz, Arturo Amílcar

; Uribe Moya, Silvia Elena

; Morgado Villaseñor, Luis Antonio

; Flores Ramírez, Raymundo

; Salmerón, José David

; Gasca Aldama, José Antonio

; Deloya Tomas, Ernesto

Medicina crítica (Colegio Mexicano de Medicina Crítica)

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feb 2020, Volume 34 N. 1 Pages 43 - 52

Abstract: Es En Pt | Text: Es En Pt | PDF: Es | PDF: En | PDF: Pt

Resumen: El 31 de diciembre de 2019 se reportaron en Wuhan, China los primeros casos de neumonía de origen desconocido, más tarde identificado como nuevo Coronavirus (2019-nCoV o COVID-19), genéticamente distinto de otros coronavirus como SARS-CoV y MERS-CoV, oficialmente identificado como SARS-CoV-2. En marzo de 2020, la Organización Mundial de la Salud (OMS) declaró alerta de pandemia por esta enfermedad, que ha infectado a miles de personas como consecuencia de afección pulmonar por síndrome de distrés respiratorio agudo (SDRA), por lo que es prioridad conocer el abordaje de manejo para el COVID-19.

Abstract: On December 31, 2019, the first cases of pneumonia of unknown origin were reported in Wuhan, China, later identified as a new Coronavirus (2019-nCoV or COVID-19), genetically distinct from other coronaviruses such as SARS-CoV and MERS-CoV, officially identified as SARS-CoV-2. In March 2020, the World Health Organization (WHO) declared a pandemic alert for this disease, which has infected thousands of people, as a consequence of pulmonary affection due to acute respiratory distress syndrome (ARDS), making it a priority to know the management approach for COVID-19.

Resumo: Em 31 de dezembro de 2019, os primeiros casos de pneumonia de origem desconhecida foram relatados em Wuhan, China, posteriormente identificado como um novo Coronavírus (2019-nCoV ou COVID-19), geneticamente diferente de outros coronavírus, como SARS-CoV e MERS-CoV , oficialmente identificado como SARS-CoV-2. Em março de 2020, a Organização Mundial da Saúde (OMS) declarou um alerta de pandemia para esta doença, que infectou milhares de pessoas, como consequência de uma doença pulmonar devido à síndrome do desconforto respiratório agudo (SDRA), tornando-se uma prioridade conhecer a abordagem de gerenciamento do COVID-19.

https://doi.org/10.35366/93280 81 downloads

10.

Reflexiones sobre el uso de opioides para el tratamiento del dolor crónico no-oncológico en México
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Covarrubias-Gómez, Alfredo

; Templos-Estebán, Luz A

; Esquer-Guzmán, Héctor M

; Carrillo-Torres, Orlando

; Pavón-Sánchez, Rodrigo A

; Arriaga-Morales, Ernesto

; Ferretiz-López, Giancarlo

; Sámano-García, Marcela

; Suárez-García, Irma B

; Baez-Baez, Jorge U

; Salinas-Palacios, Cinthia K

; Gutiérrez-Salmerón, Claudia

; Valencia-Flores, Yosemit

; Otero-Lamas, Margarita

Revista mexicana de anestesiología

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dec 2019, Volume 42 N. 4 Pages 312 - 314

Abstract: Es | Text: Es | PDF: Es

191 downloads

11.

Associations between dietary patterns and metabolic syndrome in adolescents
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Ramírez-López, Guadalupe

; Flores-Aldana, Mario

; Salmerón, Jorge

Salud Pública de México

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oct 2019, Volume 61 N. 5 Pages 619 - 628

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Abstract: Objective: Evaluate association of dietary patterns with metabolic syndrome (MetS) and metabolic markers. Materials and methods: 654 adolescents from Guadalajara, Jalisco, participated in a cross-sectional study. Diet was evaluated using a food frequency questionnaire; 24 food groups were integrated, and dietary patterns were derived using cluster analysis. MetS was defined according to International Diabetes Federation (IDF), Cook and colleagues, Ford and colleagues, and de Ferranti and colleagues criteria. Results: Dietary patterns identified were: “DP1”, “DP2”, and “DP3”. Among males, “DP3” was associated with MetS (Cook and collaborators) (OR, 12.14; 95%CI, 1.66-89.05), hypertriglyceridemia (OR, 3.89; 95%CI, 1.01-15.07), and insulin resistance (OR, 6.66; 95%CI, 1.12-39.70). “DP2” was associated with abdominal obesity (OR, 5.11; 95%CI, 1.57-16.66). Conclusions: “DP3” entertained a greater risk of MetS, hypertriglyceridemia, and insulin resistance, while “DP2” possessed a greater risk of abdominal obesity among adolescent males.

Resumen: Objetivo: Evaluar la asociación de patrones dietarios (PD) con síndrome metabólico (SM) y marcadores metabólicos. Material y métodos: Estudio transversal con 654 adolescentes. Dieta evaluada con el cuestionario “frecuencia de consumos de alimentos”; se identificaron 24 grupos de alimentos, para obtener PD mediante análisis de conglomerados. SM se definió según los criterios: Federación de Diabetes Internacional (IDF), Cook y colaboradores, Ford y colaboradores y Ferranti y colaboradores. Resultados: Se identificaron tres PD: “PD1”, “PD2” y “PD3”. En hombres, “PD3” se asoció con SM (Cook y colaboradores) (RM, 12.14; IC95%, 1.66-89.05), hipertrigliceridemia (RM, 3.89; IC95%, 1.01-15.07) y resistencia a insulina (RM, 6.66; IC95%, 1.12-39.70). El patrón “PD2” se asoció con obesidad abdominal (RM, 5.11; IC95%, 1.57-16.66). Conclusiones: El patrón “PD3” aumenta el riesgo de SM, hipertrigliceridemia y resistencia a insulina y el “PD2” el riesgo de obesidad abdominal en adolescentes hombres.

https://doi.org/10.21149/9541 580 downloads

12.

Associations between dietary patterns and metabolic syndrome in adolescents
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Ramírez-López, Guadalupe

; Flores-Aldana, Mario

; Salmerón, Jorge

Salud Pública de México

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oct 2019, Volume 61 N. 5 Pages 619 - 628

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

https://doi.org/10.21149/9541

13.

Preventive health services and physical activity improve health-related quality of life in Mexican older adults
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Gallegos-Carrillo, Katia

; Honorato-Cabañas, Yesenia

; Macías, Nayeli

; García-Peña, Carmen

; Flores, Yvonne N

; Salmerón, Jorge

Salud Pública de México

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apr 2019, Volume 61 N. 2 Pages 106 - 115

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Abstract: Objective: To evaluate the combined use of IMSS preventive health services (PHS) and the practice of physical activity (PA) in order to determine their association with the perceived health-related quality of life (HRQoL) of older adults. Materials and methods: A survey-based cross-sectional study was conducted at nine primary health care units (PHCUs) in Mexico City. The 36-Item Short-Form Health Survey evaluated the HRQoL, while PA and PHS use were assessed through self-report. Linear regression analyses were performed to determine the relationship between these three variables. Results: Of the 1 085 older adults who participated in the study, 36.8% used PHS, and 23.3% reported that they engage in PA. After controlling for possible effects due to sociodemographic and health differences, we found that participants who were physically active and used PHS reported better perceived HRQoL scores. Conclusions: The combined use of preventive practices such as the use of PHS and the practice of PA can help improve the perceived HRQoL of older adults.

Resumen: Objetivo: Determinar la asociación del uso combinado de servicios de salud preventiva (SSP) y la práctica de la actividad física (AF) sobre la calidad de vida relacionada con la salud (CVRS) de los adultos mayores en México. Material y métodos: Estudio transversal en unidades de atención primaria. La percepción de CVRS fue evaluada a través del instrumento SF-36; el nivel de AF, y el uso de SSP, a través de auto-reporte. Se realizaron análisis de regresión lineal para determinar la relación entre estas tres variables. Resultados: De los 1 085 adultos mayores que participaron en el estudio, 36.8% usaron SSP y 23.3% informaron practicar AF. Los adultos mayores físicamente activos y que usaban SSP reportaron una mejor puntuación de CVRS percibida, ajustando por variables de salud y sociodemográficas. Conclusiones: Prácticas preventivas como la actividad física en conjunto con el uso de servicios preventivos pueden ser útiles para mejorar la percepción de CVRS de los adultos mayores.

https://doi.org/10.21149/9400

14.

Preventive health services and physical activity improve health-related quality of life in Mexican older adults
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Gallegos-Carrillo, Katia

; Honorato-Cabañas, Yesenia

; Macías, Nayeli

; García-Peña, Carmen

; Flores, Yvonne N

; Salmerón, Jorge

Salud Pública de México

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apr 2019, Volume 61 N. 2 Pages 106 - 115

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

https://doi.org/10.21149/9400 859 downloads

15.

The effect of a booster dose of HPV tetravalent vaccine after 51 months: implications for extended vaccination schedules
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Lazcano-Ponce, Eduardo

; Carnalla-Cortés, Martha

; Barrientos-Gutiérrez, Tonatiuh

; Torres-Ibarra, Leticia

; Cruz-Valdez, Aurelio

; Salmerón, Jorge

; Hernández-Ávila, Mauricio

Salud Pública de México

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dec 2018, Volume 60 N. 6 Pages 666 - 673

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Abstract: Objective: To asses the non-inferiority between two different vaccination schedules one month after the administration of the third dose. Materials and methods: We evaluated the anti-HPV 16/18 antibody titers induced by quadrivalent HPV vaccine administered using two different schedules in girls 9 to 10-year-old girls: a traditional (0-2-6) and an alternative (0-6-50). Blood samples were collected at month 7, 21 and 51. Results: The antibody geometric mean titer ratios one month after the application of the third dose -month 51 for the alternative and month 7 for the traditional- were 1.55 for HPV16 (95%CI, 1.15-2.08) and 1.53 for HPV18 (95%CI, 1.12-2.09). The seropositive rate was above 99% in both groups. Conclusions: The application of an alternative 3-dose schedule in 9 to 10-year-old girls induces a non-inferior immune response compared to the standard one month after the last dose. Further research is needed to understand the minimal number of doses and their timing to provide the best coverage for HPV infection.

Resumen: Objetivo: Evaluar la no inferioridad entre dos diferentes esquemas de vacunación un mes después de la administración de la tercera dosis. Material y métodos: Se evaluaron los títulos de anticuerpos anti-VPH 16/18 inducidos por la vacuna contra VPH tetravalente administrada en niñas de 9 a 10 años utilizando dos esquemas diferentes: tradicional (0-2-6) y alternativo (0-6-50). Se recolectaron muestras en los meses 7, 21 y 51. Resultados: La media geométrica de títulos de anticuerpos un mes después de la aplicación de la tercera dosis -mes 51 para la alternativa y mes 7 para el tradicional- fueron 1.55 para HPV16 (95% IC 1.15-2.08) y 1.53 para HPV18 (95% IC 1.12-2.09). La tasa de seropositividad fue superior a 99% en ambos grupos. Conclusiones: la aplicación de un esquema alternativo de tres dosis (0-6-50 meses) en niñas parece inducir una respuesta inmune no inferior al esquema tradicional un mes después de la última dosis. Se necesitan más estudios para determinar las dosis mínimas e intervalos óptimos para obtener la mejor cobertura para la infección por VPH.

https://doi.org/10.21149/10183

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