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Abstract Since the inception of COVID-19 pandemic, there has been a challenging race for the development of precise diagnostic tests. Specific SARS-CoV-2 serological assays are the main tools used to estimate the rate of past infections or herd immunity in epidemiological studies, in addition to being helpful in guiding public health management policies. In this study, an in-house ELISA based on the construct of SARS-CoV-2 nucleocapsid (N) proteins, named rCoV2, rCoV4, and rCoV7, showed diagnostic performance for the detection of IgG antibodies. Sensitivity was evaluated in serum samples from patients with mild to moderate or severe COVID-19 infections, which were collected at different time points, while specificity was evaluated using pre-pandemic sera. In samples from mild to moderate cases obtained ≥16 days after the onset of symptoms, the sensitivities for rCoV2, rCoV4, and rCoV7 were 66.7%, 75%, and 77.8%, respectively. For samples from severe cases, the sensitivity was above 80% for all constructs. All proteins showed high specificity (94-98%). Overall, rCoV7 (C-terminus N-protein portion) showed better diagnostic performance, with 62.3% sensitivity in moderate and severe cases and 96.6% specificity. The SARS-CoV-2 ELISA using N-protein-based constructs could be a promisor tool for investigate the epidemiology of COVID-19 and monitor population-level serosurveillance. COVID19 COVID 19 COVID-1 pandemic tests SARSCoV2 SARSCoV SARS CoV 2 SARS-CoV- studies policies study inhouse house N (N rCoV2 rCoV rCoV4 antibodies points prepandemic pre sera 16 ≥1 symptoms 667 66 7 66.7% 75 75% 778 77 8 77.8% respectively 80 9498%. 9498 94 98% . 98 (94-98%) Overall Cterminus C terminus Nprotein protein portion 623 62 3 62.3 966 96 6 96.6 Nproteinbased populationlevel population level serosurveillance COVID1 1 COVID- SARS-CoV ≥ 66.7 77.8 9498% 949 9 (94-98% 62. 96. 66. 77. (94-98 (94-9 (94- (94 (9 (

https://doi.org/10.1590/1678-4324-2024230196

Post Ligation Cardiac Syndrome: an Educational Presentation
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Silva, Isaac Azevedo

; Corso, Ricardo Barros

; Pina, Glauco

; Santos, Marcus Vinicius Nascimento

; Souza, Helmgton José Brito de

; Fenelon, Maria Paula Meireles

; Alves, Leonardo Jadyr Silva Rodrigues

; Vasconcelos, Diane Lucio

; Marques, Viviane Bastos Paixão

Brazilian Journal of Cardiovascular Surgery

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feb 2022, Volume 37 N. 1 Pages 128 - 130

Abstract: En | Text: En | PDF: En

ABSTRACT Although technically simple, surgical correction of patent ductus arteriosus can have serious complications. In this context, acute ventricular failure must be remembered, as its prompt diagnosis and proper management can change clinical outcomes.

https://doi.org/10.21470/1678-9741-2020-0278

Recommendations by the Scientific Department of Neuroimmunology of the Brazilian Academy of Neurology (DCNI/ABN) and the Brazilian Committee for Treatment and Research in Multiple Sclerosis and Neuroimmunological Diseases (BCTRIMS) on vaccination in general and specifically against SARS-CoV-2 for patients with demyelinating diseases of the central nervous system
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Becker, Jefferson

; Ferreira, Lis Campos

; Damasceno, Alfredo

; Bichuetti, Denis Bernardi

; Christo, Paulo Pereira

; Callegaro, Dagoberto

; Peixoto, Marco Aurélio Lana

; Sousa, Nise Alessandra De Carvalho

; Almeida, Sérgio Monteiro De

; Adoni, Tarso

; Santiago-Amaral, Juliana

; Junqueira, Thiago

; Pereira, Samira Luisa Apóstolos

; Gomes, Ana Beatriz Ayroza Galvão Ribeiro

; Pitombeira, Milena

; Paolilo, Renata Barbosa

; Grzesiuk, Anderson Kuntz

; Piccolo, Ana Claudia

; D´Almeida, José Arthur Costa

; Gomes Neto, Antonio Pereira

; Oliveira, Augusto Cesar Penalva De

; Oliveira, Bianca Santos De

; Tauil, Carlos Bernardo

; Vasconcelos, Claudia Ferreira

; Kaimen-Maciel, Damacio

; Varela, Daniel

; Diniz, Denise Sisterolli

; Oliveira, Enedina Maria Lobato De

; Malfetano, Fabiola Rachid

; Borges, Fernando Elias

; Figueira, Fernando Faria Andrade

; Gondim, Francisco De Assis Aquino

; Passos, Giordani Rodrigues Dos

; Silva, Guilherme Diogo

; Olival, Guilherme Sciascia Do

; Santos, Gutemberg Augusto Cruz Dos

; Ruocco, Heloisa Helena

; Sato, Henry Koiti

; Soares Neto, Herval Ribeiro

; Cortoni Calia, Leandro

; Gonçalves, Marcus Vinícius Magno

; Vecino, Maria Cecilia Aragón De

; Pimentel, Maria Lucia Vellutini

; Ribeiro, Marlise De Castro

; Boaventura, Mateus

; Parolin, Mônica Koncke Fiuza

; Melo, Renata Brant De Souza

; Lázaro, Robson

; Thomaz, Rodrigo Barbosa

; Kleinpaul, Rodrigo

; Dias, Ronaldo Maciel

; Gomes, Sidney

; Lucatto, Simone Abrante

; Alves-Leon, Soniza Vieira

; Fukuda, Thiago

; Ribeiro, Taysa Alexandrino Gonsalves Jubé

; Winckler, Thereza Cristina D’ávila

; Fragoso, Yara Dadalti

; Nascimento, Osvaldo José Moreira Do

; Ferreira, Maria Lucia Brito

; Mendes, Maria Fernanda

; Brum, Doralina Guimarães

; Glehn, Felipe Von

Arquivos de Neuro-Psiquiatria

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nov 2021, Volume 79 N. 11 Pages 1049 - 1061

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO O DC de Neuroimunologia da ABN e o BCTRIMS trazem, nesse documento, as recomendações sobre vacinação da população com doenças desmielinizantes do sistema nervoso central (SNC) contra infecções em geral e contra o coronavírus da síndrome respiratória aguda grave 2 (SARS-CoV-2), causador da COVID-19. Destaca-se a gravidade do atual momento frente ao avanço da COVID-19 em nosso País, o que torna mais evidente e importante a criação de guia de referência para orientação aos médicos, pacientes e autoridades de saúde pública quanto à vacinação, meio efetivo e seguro no controle de determinadas doenças infecciosa. O DCNI/ABN e o BCTRIMS recomendam que os pacientes com doenças desmielinizantes do SNC (ex., EM e NMOSD) sejam constantemente monitorados, quanto a atualização do seu calendário vacinal, especialmente, no início ou antes da mudança do tratamento com uma droga modificadora de doença (DMD). É importante também salientar que as vacinas são seguras e os médicos devem estimular o seu uso em todos os pacientes. Evidentemente, deve ser dada especial atenção às vacinas com vírus vivos atenuados. Por fim, é importante que os médicos verifiquem qual DMD o paciente está em uso e quando foi feita a sua última dose, pois cada fármaco pode interagir de forma diferente com a indução da resposta imune.

ABSTRACT The Scientific Department of Neuroimmunology of the Brazilian Academy of Neurology (DCNI/ABN) and Brazilian Committee for Treatment and Research in Multiple Sclerosis and Neuroimmunological Diseases (BCTRIMS) provide recommendations in this document for vaccination of the population with demyelinating diseases of the central nervous system (CNS) against infections in general and against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes COVID-19. We emphasize the seriousness of the current situation in view of the spread of COVID-19 in our country. Therefore, reference guides on vaccination for clinicians, patients, and public health authorities are particularly important to prevent some infectious diseases. The DCNI/ABN and BCTRIMS recommend that patients with CNS demyelinating diseases (e.g., MS and NMOSD) be continually monitored for updates to their vaccination schedule, especially at the beginning or before a change in treatment with a disease modifying drug (DMD). It is also important to note that vaccines are safe, and physicians should encourage their use in all patients. Clearly, special care should be taken when live attenuated viruses are involved. Finally, it is important for physicians to verify which DMD the patient is receiving and when the last dose was taken, as each drug may affect the induction of immune response differently.

https://doi.org/10.1590/0004-282x-anp-2021-0162 1 downloads

Atualização de Tópicos Emergentes da Diretriz Brasileira de Insuficiência Cardíaca – 2021
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Marcondes-Braga, Fabiana G.

; Moura, Lídia Ana Zytynski

; Issa, Victor Sarli

; Vieira, Jefferson Luis

; Rohde, Luis Eduardo

; Simões, Marcus Vinícius

; Fernandes-Silva, Miguel Morita

; Rassi, Salvador

; Alves, Silvia Marinho Martins

; Albuquerque, Denilson Campos de

; Almeida, Dirceu Rodrigues de

; Bocchi, Edimar Alcides

; Ramires, Felix José Alvarez

; Bacal, Fernando

; Rossi Neto, João Manoel

; Danzmann, Luiz Claudio

; Montera, Marcelo Westerlund

; Oliveira Junior, Mucio Tavares de

; Clausell, Nadine

; Silvestre, Odilson Marcos

; Bestetti, Reinaldo Bulgarelli

; Bernadez-Pereira, Sabrina

; Freitas Jr, Aguinaldo F.

; Biolo, Andréia

; Barretto, Antonio Carlos Pereira

; Jorge, Antônio José Lagoeiro

; Biselli, Bruno

; Montenegro, Carlos Eduardo Lucena

; Santos Júnior, Edval Gomes dos

; Figueiredo, Estêvão Lanna

; Fernandes, Fábio

; Silveira, Fabio Serra

; Atik, Fernando Antibas

; Brito, Flávio de Souza

; Souza, Germano Emílio Conceição

; Ribeiro, Gustavo Calado de Aguiar

; Villacorta, Humberto

; Souza Neto, João David de

; Goldraich, Livia Adams

; Beck-da-Silva, Luís

; Canesin, Manoel Fernandes

; Bittencourt, Marcelo Imbroinise

; Bonatto, Marcely Gimenes

; Moreira, Maria da Consolação Vieira

; Avila, Mônica Samuel

; Coelho Filho, Otavio Rizzi

; Schwartzmann, Pedro Vellosa

; Mourilhe-Rocha, Ricardo

; Mangini, Sandrigo

; Ferreira, Silvia Moreira Ayub

; Figueiredo Neto, José Albuquerque de

; Mesquita, Evandro Tinoco

Arquivos Brasileiros de Cardiologia

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jun 2021, Volume 116 N. 6 Pages 1174 - 1212

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.36660/abc.20210367 3168 downloads

Agreement Analysis between Sonographic Estimates and Birth Weight, by the WHO and Intergrowth-21st Tables, in Newborns of Diabetic Mothers
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Souza, Marcus Vinícius Rodrigues de

; Fróes, Lívia Pinto e

; Cortez, Pedro Afonso

; Lauria, Márcio Weissheimer

; Aguiar, Regina Amélia Lopes de

; Rajão, Kamilla Maria Araújo Brandão

Revista Brasileira de Ginecologia e Obstetrícia

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jan 2021, Volume 43 N. 1 Pages 20 - 27

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Objetivo Analisar a concordância, em relação ao percentil 90, das medidas ultrassonográficas da circunferência abdominal (CA) e peso fetal estimado (PFE), entre as tabelas da Organização Mundial de Saúde (OMS) e do International Fetal and Newborn Growth Consortium for the 21st Century integrowth-21st, bem como em relação ao peso ao nascer em fetos/recém-nascidos de mães diabéticas. Métodos Estudo retrospectivo com dados de prontuários de 171 gestantes diabéticas, com gestações únicas, seguidas entre Janeiro de 2017 e Junho de 2018. Foram analisados dados da CA e do PFE na admissão (a partir de 22 semanas) e no pré-parto (até 3 semanas). Essas medidas foram classificadas em relação ao percentil 90. O coeficiente Kappa foi utilizado para analisar a concordância entre as tabelas da OMS e Intergrowth-21st, assim como, por tabela de referência, entre as medidas e o peso ao nascer. Resultados O estudo da OMS relatou 21,6% dos recém nascidos grandes para a idade gestacional (GIG) enquanto que o estudo do intergrowth-21st relatou 32,2%. Ambas as tabelas tiveram fortes concordâncias na avaliação da CA inicial e final e PFE inicial (Kappa= 0,66, 0,72 e 0,63, respectivamente) e concordância quase perfeita em relação ao PFE final (Kappa= 0,91).Emrelação ao peso ao nascer, asmelhores concordâncias foram encontradas para aCAinicial (OMS: Kappa= 0,35; intergrowth-21st: Kappa= 0,42) e como PFE final (OMS: Kappa = 0,33; intergrowth-21st: Kappa= 0,35). Conclusão A CA inicial e o PFE final foram os parâmetros de melhor concordância em relação à classificação do peso ao nascer. As tabelas da OMS e intergrowth-21st mostraram alta concordância na classificação das medidas ultrassonográficas em relação ao percentil 90. Estudos são necessários para confirmar se alguma dessas tabelas é superior na previsão de resultados negativos a curto e longo prazo no grupo GIG.

Abstract Objective To analyze the agreement, in relation to the 90th percentile, of ultrasound measurements of abdominal circumference (AC) and estimated fetal weight (EFW), between the World Health Organization (WHO) and the International Fetal and Newborn Growth Consortium for the 21st Century (intergrowth-21st) tables, as well as regarding birth weight in fetuses/newborns of diabetic mothers. Methods Retrospective study with data from medical records of 171 diabetic pregnant women, single pregnancies, followed between January 2017 and June 2018. Abdominal circumference and EFW data at admission (from 22 weeks) and predelivery (up to 3 weeks) were analyzed. These measures were classified in relation to the 90th percentile. The Kappa coefficient was used to analyze the agreement of these ultrasound variables between the WHO and intergrowth-21st tables, as well as, by reference table, these measurements and birth weight. Results The WHO study reported 21.6% large-for-gestational-age (LGA) newborns while the intergrowth-21st reported 32.2%. Both tables had strong concordances in the assessment of initial AC, final AC, and initial EFW (Kappa = 0.66, 0.72 and 0.63, respectively) and almost perfect concordance in relation to final EFW (Kappa = 0.91). Regarding birth weight, the best concordances were found for initial AC (WHO: Kappa = 0.35; intergrowth-21st: Kappa= 0.42) and with the final EFW (WHO: Kappa = 0.33; intergrowth- 21st: Kappa = 0.35). Conclusion The initial AC and final EFW were the parameters of best agreement regarding birth weight classification. The WHO and intergrowth-21st tables showed high agreement in the classification of ultrasound measurements in relation to the 90th

https://doi.org/10.1055/s-0040-1719146 265 downloads

Collective efficacy in soccer teams: a systematic review
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Alves, Mylena Aparecida Rodrigues

; Lencina, Marcus Vinicius de Souza

; Paes, Mayara Juliana

; Stefanello, Joice Mara Facco

Psicologia: Reflexão e Crítica

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2021, Volume 34 elocation 18

Abstract: En | Text: En | PDF: En

Abstract Collective efficacy, defined as a group’s shared belief about its conjoint capability to organize and execute courses of action, plays a pivotal role in understanding the dynamics of sports teams, since it influences what individuals choose to do as team members, how much they invest in motivational terms to perform actions, how much they work collectively, and for how long they persist despite failure. Through a systematic review, it was investigated how collective efficacy has been assessed in the context of soccer and which indicators, attributes, and psychometric properties have been contemplated in the instruments used. Following the PRISMA guidelines, 22 articles were retrieved through electronic databases (APA PsycINFO; SPORTDiscus; Science Direct; BVS; Web of Science; Scopus; PubMed; and Scielo), using as descriptors, in English, Spanish, and Portuguese, collective efficacy and soccer, combined by the Boolean operators AND and OR. The study did not delimit the initial year of publication for the searches carried out, including all articles found until January 14, 2021 (date of the last update). The following eligibility criteria were adopted: scientific articles published in journals; original studies, which specified the instrument used to assess collective efficacy and carried out with soccer athletes. Five instruments (FCEQ, CEQS, CEI, CEC, and CEQsoccer) that evaluated technical-tactical and psychological attributes associated with collective efficacy in soccer players were identified. In most studies, psychometric properties were restricted to content validity and reliability (internal consistency), and there were no suitable validation processes for the instruments used to measure collective efficacy, which can be considered a limiting factor for understanding this psychological construct in soccer modality.

https://doi.org/10.1186/s41155-021-00183-y 47 downloads

Implications for Clinical Practice from a Multicenter Survey of Heart Failure Management Centers
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Bocchi, Edimar Alcides

; Moreira, Henrique Turin

; Nakamuta, Juliana Sanajotti

; Simões, Marcus Vinicius

; Casas, Alberto de Almeida Las

; Costa, Altamiro Reis da

; Assis, Amberson Vieira de

; Durães, André Rodrigues

; Pereira-Barretto, Antonio Carlos

; Ravessa, Antonio Delduque de Araujo

; Macedo, Ariane Vieira Scarlatelli

; Biselli, Bruno

; Pinto, Carolina Maria Nogueira

; Filho, Conrado Roberto Hoffmann

; Costantini, Costantino Roberto

; Almeida, Dirceu Rodrigues

; Santos Jr, Edval Gomes dos

; Soliva Junior, Erwin

; Figueiredo, Estevão Lanna

; Albuquerque, Felipe Neves de

; Paulitsch, Felipe

; Neuenschwander, Fernando Carvalho

; Figueiredo Neto, José Albuquerque de

; Brito, Flavio de Souza

; Lopes, Heno Ferreira

; Villacorta, Humberto

; Souza Neto, João David de

; Sepulveda, João Mariano

; Ayoub, José Carlos Aidar

; Vilela-Martin, José F.

; Cardoso, Juliano Novaes

; Uemura, Laercio

; Moura, Lidia Zytynski

; Maia, Lilia Nigro

; Oliveira, Lucia Brandão de

; Maia, Lucimir

; Silva, Luís Beck da

; Gowdak, Luís Henrique Wolff

; Danzmann, Luiz Claudio

; Andrade, Marcus

; Braile-Sternieri, Maria Christiane Valeria Braga

; Moreira, Maria da Consolação Vieira

; França Neto, Olimpio R

; Filho, Otavio Rizzi Coelho

; Esteves, Paulo Frederico

; Raupp-da-Rosa, Priscila

; Silva, Ricardo Jorge de Queiroz e

; Mourilhe-Rocha, Ricardo

; Viégas, Ruy Felipe Melo

; Rassi, Salvador

; Mangili, Sandrigo

; Kaiser, Sergio Emanuel

; Martins, Silvia Marinho

; Kawabata, Vitor Sergio

Clinics

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2021, Volume 76 elocation e1991

Abstract: En | Text: En | PDF: En

OBJECTIVES: This observational, cross-sectional study based aimed to test whether heart failure (HF)-disease management program (DMP) components are influencing care and clinical decision-making in Brazil. METHODS: The survey respondents were cardiologists recommended by experts in the field and invited to participate in the survey via printed form or email. The survey consisted of 29 questions addressing site demographics, public versus private infrastructure, HF baseline data of patients, clinical management of HF, performance indicators, and perceptions about HF treatment. RESULTS: Data were obtained from 98 centers (58% public and 42% private practice) distributed across Brazil. Public HF-DMPs compared to private HF-DMP were associated with a higher percentage of HF-DMP-dedicated services (79% vs 24%; OR: 12, 95% CI: 94-34), multidisciplinary HF (MHF)-DMP [84% vs 65%; OR: 3; 95% CI: 1-8), HF educational programs (49% vs 18%; OR: 4; 95% CI: 1-2), written instructions before hospital discharge (83% vs 76%; OR: 1; 95% CI: 0-5), rehabilitation (69% vs 39%; OR: 3; 95% CI: 1-9), monitoring (44% vs 29%; OR: 2; 95% CI: 1-5), guideline-directed medical therapy-HF use (94% vs 85%; OR: 3; 95% CI: 0-15), and less B-type natriuretic peptide (BNP) dosage (73% vs 88%; OR: 3; 95% CI: 1-9), and key performance indicators (37% vs 60%; OR: 3; 95% CI: 1-7). In comparison to non- MHF-DMP, MHF-DMP was associated with more educational initiatives (42% vs 6%; OR: 12; 95% CI: 1-97), written instructions (83% vs 68%; OR: 2: 95% CI: 1-7), rehabilitation (69% vs 17%; OR: 11; 95% CI: 3-44), monitoring (47% vs 6%; OR: 14; 95% CI: 2-115), GDMT-HF (92% vs 83%; OR: 3; 95% CI: 0-15). In addition, there were less use of BNP as a biomarker (70% vs 84%; OR: 2; 95% CI: 1-8) and key performance indicators (35% vs 51%; OR: 2; 95% CI: 91,6) in the non-MHF group. Physicians considered changing or introducing new medications mostly when patients were hospitalized or when observing worsening disease and/or symptoms. Adherence to drug treatment and non-drug treatment factors were the greatest medical problems associated with HF treatment. CONCLUSION: HF-DMPs are highly heterogeneous. New strategies for HF care should consider the present study highlights and clinical decision-making processes to improve HF patient care.

https://doi.org/10.6061/clinics/2021/e1991 870 downloads

The Program for Biodiversity Research in Brazil: The role of regional networks for biodiversity knowledge, dissemination, and conservation
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ROSA, CLARISSA

; BACCARO, FABRICIO

; CRONEMBERGER, CECILIA

; HIPÓLITO, JULIANA

; BARROS, CLAUDIA FRANCA

; RODRIGUES, DOMINGOS DE JESUS

; NECKEL-OLIVEIRA, SELVINO

; OVERBECK, GERHARD E.

; DRECHSLER-SANTOS, ELISANDRO RICARDO

; ANJOS, MARCELO RODRIGUES DOS

; FERREGUETTI, ÁTILLA C.

; AKAMA, ALBERTO

; MARTINS, MARLÚCIA BONIFÁCIO

; TOMAS, WALFRIDO MORAES

; SANTOS, SANDRA APARECIDA

; FERREIRA, VANDA LÚCIA

; CUNHA, CATIA NUNES DA

; PENHA, JERRY

; PINHO, JOÃO BATISTA DE

; SALIS, SUZANA MARIA

; DORIA, CAROLINA RODRIGUES DA COSTA

; PILLAR, VALÉRIO D.

; PODGAISKI, LUCIANA R.

; MENIN, MARCELO

; BÍGIO, NARCÍSIO COSTA

; ARAGÓN, SUSAN

; MANZATTO, ANGELO GILBERTO

; VÉLEZ-MARTIN, EDUARDO

; SILVA, ANA CAROLINA BORGES LINS E

; IZZO, THIAGO JUNQUEIRA

; MORTATI, AMANDA FREDERICO

; GIACOMIN, LEANDRO LACERDA

; ALMEIDA, THAÍS ELIAS

; ANDRÉ, THIAGO

; SILVEIRA, MARIA AUREA PINHEIRO DE ALMEIDA

; SILVEIRA, ANTÔNIO LAFFAYETE PIRES DA

; MESSIAS, MARILUCE REZENDE

; MARQUES, MARCIA C.M.

; PADIAL, ANDRE ANDRIAN

; MARQUES, RENATO

; BITAR, YOUSZEF O.C.

; SILVEIRA, MARCOS

; MORATO, ELDER FERREIRA

; PAGOTTO, RUBIANI DE CÁSSIA

; STRUSSMANN, CHRISTINE

; MACHADO, RICARDO BOMFIM

; AGUIAR, LUDMILLA MOURA DE SOUZA

; FERNANDES, GERALDO WILSON

; OKI, YUMI

; NOVAIS, SAMUEL

; FERREIRA, GUILHERME BRAGA

; BARBOSA, FLÁVIA RODRIGUES

; OCHOA, ANA C.

; MANGIONE, ANTONIO M.

; GATICA, AILIN

; CARRIZO, MARÍA CELINA

; RETTA, LUCÍA MARTINEZ

; JOFRÉ, LAURA E.

; CASTILLO, LUCIANA L.

; NEME, ANDREA M.

; RUEDA, CARLA

; TOLEDO, JOSÉ JULIO DE

; GRELLE, CARLOS EDUARDO VIVEIROS

; VALE, MARIANA M.

; VIEIRA, MARCUS VINICIUS

; CERQUEIRA, RUI

; HIGASHIKAWA, EMÍLIO MANABU

; MENDONÇA, FERNANDO PEREIRA DE

; GUERREIRO, QUÊZIA LEANDRO DE MOURA

; BANHOS, AUREO

; HERO, JEAN-MARC

; KOBLITZ, RODRIGO

; COLLEVATTI, ROSANE GARCIA

; SILVEIRA, LUÍS FÁBIO

; VASCONCELOS, HERALDO L.

; VIEIRA, CECÍLIA RODRIGUES

; COLLI, GUARINO RINALDI

; CECHIN, SONIA ZANINI

; SANTOS, TIAGO GOMES DOS

; FONTANA, CARLA S.

; JARENKOW, JOÃO A.

; MALABARBA, LUIZ R.

; RUEDA, MARTA P.

; ARAUJO, PUBLIO A.

; PALOMO, LUCAS

; ITURRE, MARTA C.

; BERGALLO, HELENA GODOY

; MAGNUSSON, WILLIAM E.

Anais da Academia Brasileira de Ciências

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2021, Volume 93 N. 2 elocation e20201604

Abstract: En | Text: En | PDF: En

Abstract The Program for Biodiversity Research (PPBio) is an innovative program designed to integrate all biodiversity research stakeholders. Operating since 2004, it has installed long-term ecological research sites throughout Brazil and its logic has been applied in some other southern-hemisphere countries. The program supports all aspects of research necessary to understand biodiversity and the processes that affect it. There are presently 161 sampling sites (see some of them at Supplementary Appendix), most of which use a standardized methodology that allows comparisons across biomes and through time. To date, there are about 1200 publications associated with PPBio that cover topics ranging from natural history to genetics and species distributions. Most of the field data and metadata are available through PPBio web sites or DataONE. Metadata is available for researchers that intend to explore the different faces of Brazilian biodiversity spatio-temporal variation, as well as for managers intending to improve conservation strategies. The Program also fostered, directly and indirectly, local technical capacity building, and supported the training of hundreds of undergraduate and graduate students. The main challenge is maintaining the long-term funding necessary to understand biodiversity patterns and processes under pressure from global environmental changes.

https://doi.org/10.1590/0001-3765202120201604 1034 downloads

10.

Current vector control challenges in the fight against malaria in Brazil
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Baia-da-Silva, Djane Clarys

; Brito-Sousa, José Diego

; Rodovalho, Sheila Rodrigues

; Peterka, Cassio

; Moresco, Gilberto

; Lapouble, Oscar Martín Mesones

; Melo, Gisely Cardoso de

; Sampaio, Vanderson de Souza

; Alecrim, Maria das Graças Costa

; Pimenta, Paulo

; Lima, José Bento Pereira

; Lacerda, Marcus Vinícius Guimarães de

; Monteiro, Wuelton Marcelo

Revista da Sociedade Brasileira de Medicina Tropical

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2019, Volume 52 elocation e20180542

Abstract: En | Text: En | PDF: En

Abstract In Brazil, malaria is an important public health problem first reported in 1560. Historically, fluctuations in malaria cases in Brazil are attributed to waves of economic development; construction of railroads, highways, and hydroelectric dams; and population displacement and land occupation policies. Vector control measures have been widely used with an important role in reducing malaria cases. In this review article, we reviewed the vector control measures established in the Brazilian territory and aspects associated with such measures for malaria. Although some vector control measures are routinely used in Brazil, many entomological and effectiveness information still need better evidence in endemic areas where Plasmodium vivax predominates. Herein, we outlined some of the needs and priorities for future research: a) update of the cartography of malaria vectors in Brazil, adding molecular techniques for the correct identification of species and complexes of species; b) evaluation of vector competence of anophelines in Brazil; c) strengthening of local entomology teams to perform vector control measures and interpret results; d) evaluation of vector control measures, especially use of insecticide-treated nets and long-lasting insecticidal nets, estimating their effectiveness, cost-benefit, and population acceptance; e) establishment of colonies of malaria vectors in Brazil, i.e., Anopheles darlingi, to understand parasite-vector interactions better; f) study of new vector control strategies with impacts on non-endophilic vectors; g) estimation of the impact of insecticide resistance in different geographical areas; and h) identification of the relative contribution of natural and artificial breeding sites in different epidemiological contexts for transmission.

https://doi.org/10.1590/0037-8682-0542-2018 3986 downloads

11.

Unusual presentation of a disseminated oral HPV infection after combined antiretroviral therapy initiation
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Vale, Daniela Assis do

; Ferracini, Lais Magda Araújo

; Bueno, Marcus Vinícius da Silva Rodrigues

; Souza, Ana Carolina Mamana Fernandes

; Braz-Silva, Paulo Henrique

; Ortega, Karem López

Revista do Instituto de Medicina Tropical de São Paulo

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2019, Volume 61 elocation e54

Abstract: En | Text: En | PDF: En

ABSTRACT HPV clinical manifestations have their characteristics modified by the use of combined antiretroviral therapy (cART), although its incidence is unaffected by cART. We report an unusual presentation of oral HPV infection and discuss an effective treatment for disseminated HPV lesions. A 52-year-old male of Asian-origin, HIV-seropositive, presented with extensive nodular lesions throughout the oral mucosa extending to the oropharyngeal region. Biopsy followed by histopathological examination and HPV genotyping were performed. The treatment was initiated with topical application of podophyllin and trichloroacetic acid. HPV lesions in oral mucosa are generally easy to handle. Extensive lesions can make it difficult to choose an effective treatment that meets the patient’s particularities and medication availability.

https://doi.org/10.1590/s1678-9946201961054 1907 downloads

12.

Sexismo, misoginia e LGBTQfobia: desafios para promover o trabalho inclusivo no Brasil
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CORTEZ, PEDRO AFONSO

; SOUZA, MARCUS VINÍCIUS RODRIGUES DE

; SALVADOR, ANA PAULA

; OLIVEIRA, LUÍS FERNANDO ADAS

Physis: Revista de Saúde Coletiva

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2019, Volume 29 N. 4 elocation e290414

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo As práticas de violência permeiam diferentes contextos sociais, perpassando inclusive os espaços laborais. Nesse sentido, é fundamental promover o trabalho inclusivo, pois as práticas de dominação no trabalho relegam à marginalização diferentes atores sociais, incluindo mulheres e LGBTQs, ocasionando prejuízo à saúde psicossocial desses grupos. Com o intuito de contribuir nesse aspecto, propôs-se uma revisão crítica das produções sobre práticas de violência e dominação no contexto de trabalho voltado à população feminina e LGBTQs, a fim de identificar os desafios na proposição de trabalho inclusivo no Brasil. Foram empregados os descritores “trabalho” e “preconceito” ou “discriminação” em uma varredura da literatura entre 1995 e 2017 na base de dados Scielo, a qual permitiu a identificação de 54 estudos inclusos na presente revisão. Os resultados apontados pelos estudos revisados constataram violência com mulheres e LGBTQs nos diversos contextos laborais, praticada por chefes, colegas, clientes, entre outros sujeitos. Assim, apresenta-se como desafio para a proposição do trabalho inclusivo a implementação de intervenções educativas e assistenciais, respaldadas por legislações e políticas públicas que promovam o respeito e a equidade ao diverso como tônica nas organizações sociais e nos contextos de trabalho brasileiros.

Abstract Violent practices permeate different social contexts, including work spaces. In this sense, it is essential to promote inclusive work, as the practices of domination at work relegate to marginalization different social actors, including women and LGBTQs, causing harm to the psychosocial health of these groups. In order to contribute to this aspect, it was proposed a critical review of the productions on practices of violence and domination in the context of work aimed at the female population and LGBTQs, in order to identify the challenges in the proposition of inclusive work in Brazil. The descriptors “work” and “prejudice” or “discrimination” were used in a literature search between 1995 and 2017 in the Scielo database, which allowed the identification of 54 studies included in this review. The results pointed by the reviewed studies found violence with women and LGBTQs in the various work contexts, practiced by bosses, colleagues, clients, among other subjects. Thus, it is a challenge for the proposition of inclusive work to implement educational and assistance interventions, supported by laws and public policies that promote respect and equity to diversity as a keynote in Brazilian social organizations and work contexts.

https://doi.org/10.1590/s0103-73312019290414

13.

Sexismo, misoginia e LGBTQfobia: desafios para promover o trabalho inclusivo no Brasil
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CORTEZ, PEDRO AFONSO

; SOUZA, MARCUS VINÍCIUS RODRIGUES DE

; SALVADOR, ANA PAULA

; OLIVEIRA, LUÍS FERNANDO ADAS

Physis: Revista de Saúde Coletiva

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2019, Volume 29 N. 4 elocation e290414

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.1590/s0103-73312019290414 3172 downloads

14.

Desenvolvimento e caracterização de membranas de quitosana / Cissus Verticillata (L.) Nicolson & C.E. Jarvis
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Souza Neto, Antônio Alberto

; Medeiros, Luanna Abílio Diniz Melquíades de

; Fook, Marcus Vinícius Lia

; Siqueira, Rafael Rodrigues de

; Barbosa, Rossemberg Cardoso

; Moraes, Walter Gleybson Antas de

; Rosendo, Rosana Araújo

Matéria (Rio de Janeiro)

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2019, Volume 24 N. 3 elocation e12393

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Os polímeros, devido às suas diversas aplicações e funcionalidades, estão entre os excipientes mais utilizados para a obtenção de formas farmacêuticas, ganhando destaque a quitosana. O objetivo deste trabalho foi desenvolver e avaliar comparativamente membranas de quitosana com diferentes concentrações da espécie vegetal Cissus verticillata (L.) Nicolson & C.E. Jarvis (insulina), para uso em sistema de liberação de fármaco. Foi realizada coleta, identificação botânica e obtenção do extrato alcoólico bruto (EAB) da planta. Para produção das membranas de quitosana e quitosana com EAB utilizou-se a técnica de evaporação do solvente. As membranas foram divididas nos grupos: MQ (Membrana de quitosana), MQ5 (Membrana de quitosana com 5% de EAB) e MQ20 (Membrana de quitosana com 20% de EAB), sendo as amostrascaracterizadas pelas técnicas de Microscopia Ótica (MO), Microscopia Eletrônica de Varredura (MEV), de Resistência à Tração e Citotoxicidade. Analisando macroscopicamente as membranas, evidenciou-se mudança de cor à medida que o percentual do EAB foi aumentado, tornando as amostras mais escuras. As análises de MO e MEV evidenciaram membranas com superfície lisa e regular. O ensaio mecânico de resistência à tração revelou diminuição na resistência à tensão quando acrescido 5% de EAB, e aumento desta com 20% de EAB. O teste de citotoxicidade mostrou que todas as amostras são viáveis para uso em sistemas biológicos. Logo, conclui-se que foi possível desenvolver membranas de quitosana com diferentes concentrações de EAB, e que o grupo MQ possui uma maior resistência à tensão em relação aos demais grupos.

ABSTRACT The polymers, due to their diverse applications and functionalities, are among the most used excipients to obtain pharmaceutical forms, with emphasis on chitosan. This study aimed to develop and evaluate comparatively membranes of chitosan to different concentrations of the plant species Cissus verticillata (L.) Nicolson & C.E. Jarvis (insulin), in order to use in a drug delivery system. It was realized data collection, botanical identification and the obtaining of the crude alcohol extract (CAE) of the plant. For the production of chitosan and crude alcohol extracted chitosan membrane, it is used the solvent evaporation technique. The membranes were divided into groups: CM (chitosan membrane), CM5 (5% of crude alcohol extracted chitosan membrane) e CM20 (20% of crude alcohol extracted chitosan membrane), being the samples characterized by the techniques of Optical Microscopy (OM), Scanning Electron Microscopy (SEM), of Tensile Strength and Cytotoxicity. Macroscopically analyzing the membranes revealed a change in color as the percentage of CAE increased, making the samples darker. The MO and SEM analyzes showed membranes with smooth and regular surface. The mechanical tensile strength test revealed a decrease in tensile strength when 5% of CAE was added and increased with 20% of CAE. The cytotoxicity test showed that all samples are viable for use in biological systems. Therefore, it was concluded that it was possible to develop chitosan membranes with different concentrations of CAE, and that the CM group has a higher resistance to tension in relation to the other groups.

https://doi.org/10.1590/s1517-707620190003.0706 1334 downloads

15.

Princípios de uma política alternativa aos manicômios judiciais
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Cortez, Pedro Afonso

; Souza, Marcus Vinícius Rodrigues de

; Oliveira, Luís Fernando Adas

Saúde e Sociedade

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dec 2018, Volume 27 N. 4 Pages 1206 - 1217

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Os hospitais de custódia brasileiros são marcados por uma lógica de exclusão e segregação social. Indivíduos considerados inimputáveis ou semi-imputáveis são destinados a esses espaços com o intuito de cumprir medidas de segurança, mas não recebem os devidos cuidados em saúde mental, o que impossibilita a completa reintegração social e sentencia o indivíduo à marginalização. Nesse contexto, o objetivo deste ensaio foi propor princípios para definir uma Política Territorial de Reabilitação Psicossocial como alternativa aos manicômios judiciários brasileiros. Para tanto, analisou-se a formação da política territorial em saúde mental como proposta eficaz para assistência em saúde no contexto brasileiro, tecendo críticas ao modelo vigente para acompanhamento de medidas de segurança. Também se evidenciaram as contradições relativas ao processo de diagnóstico e acompanhamento em saúde mental na proposta não territorial. Assim, estabelecidos os pontos críticos do modelo excludente vigente, propôs-se uma política alternativa, cuja fundamentação territorial insere o cumprimento das medidas de segurança no contexto das políticas públicas de assistência social e saúde mental, tendo como finalidade a reabilitação integral do sujeito, tal como preconizado pela Lei nº 10.216/2001.

Abstract Brazilian judiciary asylum hospitals are marked by exclusion and social segregation. Individuals who are not considered to be criminally responsible due to mental illnesses are destined to these spaces to comply with detention orders but do not receive the necessary mental health care, making it impossible to bring them back to social coexistence, thus sentencing these individuals to marginalization. In this context, we aimed at proposing principles for the definition of a Territorial Psychosocial Rehabilitation Policy as an alternative to the Brazilian judiciary asylums. To do so, the formation of the territorial policy in mental health was analyzed as an effective proposal for health care in the Brazilian context, and criticism was proposed on the current model of monitoring detention orders. Also, the contradictions related to the process of diagnosis and follow-up in mental health in the non-territorial proposal were highlighted. Thus, after we established the critical points of the existing exclusionary model, we proposed an alternative policy, whose territorial foundation inserts the fulfillment of the detention orders into a context of social assistance and mental health care public policies, aiming at the full rehabilitation of the subject, as recommended by Law No. 10,216/2001.

https://doi.org/10.1590/s0104-12902018180409 6 downloads

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