RESUMO Introdução: Simetria é o equilíbrio ou correspondência no tamanho, na forma e na disposição das partes em lados opostos de um plano, linha ou ponto. O oposto desse conceito é assimetria ou desequilíbrio. Objetivo: Esse estudo retrospectivo comparou dois métodos de avaliação da simetria da arcada a partir de medidas lineares baseadas em triângulos, para determinar sua aplicabilidade e eficiência. Métodos: A amostra foi composta por dois grupos: crianças (n=20) e adultos (n=20), e a simetria das arcadas foi avaliada a partir de medidas lineares. Método 1: as distâncias incisivo-canino (INC), canino-molar (CM) e incisivo-molar (INM) (testet pareado e correlação de Pearson). Método 2: uma equação matemática com as medidas entre as cúspides dos caninos e a as cúspides distovestibulares dos primeiros molares, levando ao resultado 1 (teste t para uma amostra e análise de bootstrapping). Os modelos dentários foram digitalizados e analisados por meio de um software. O teste de Bland-Altman comparou os métodos (α = 0,05). Resultados: O teste de Bland-Altman revelou concordância entre os métodos; no entanto, separadamente, os resultados foram diferentes: no Método 1, a arcada inferior não demonstrou correlação (crianças, INC r=0,33; CM r=0,45; INM r=0,51; adultos, CM r=0,46; INM r=0,35); no entanto, a arcada superior revelou uma forte correlação em crianças e uma correlação forte/moderada em adultos. No Método 2, ambas as arcadas eram simétricas (p>0,05). Conclusões: O Método 1 pode ser apropriado durante o tratamento ortodôntico, e o Método 2 pode ser indicado para o tratamento final. Esses métodos são úteis; entretanto, somente o Método 1 identificou o lado da assimetria. Os métodos podem contribuir para estudos futuros em pacientes sindrômicos e não sindrômicos, antes e depois de cirurgias ortognáticas e tratamento ortodôntico, comparando os resultados. Introdução tamanho plano ponto desequilíbrio Objetivo triângulos eficiência Métodos grupos n=20 n20 n 20 (n=20 n=20, , incisivocanino incisivo canino INC, (INC) caninomolar molar (CM incisivomolar (INM testet Pearson. Pearson . Pearson) molares bootstrapping. bootstrapping bootstrapping) software BlandAltman Bland Altman α 0,05. 005 0,05 0 05 0,05) Resultados entanto separadamente diferentes crianças, (crianças r=0,33 r033 r 33 r=0,45 r045 45 r=0,51 r051 51 r=0,46 r046 46 r=0,35 r035 35 r=0,35) fortemoderada moderada p>0,05. p005 p p>0,05 (p>0,05) Conclusões ortodôntico final úteis entretanto n=2 n2 (n=2 (INC 00 0,0 r=0,3 r03 3 r=0,4 r04 4 r=0,5 r05 5 p00 p>0,0 (p>0,05 n= (n= 0, r=0, r0 p0 p>0, (p>0,0 (n r=0 p>0 (p>0, r= p> (p>0 (p> (p

ABSTRACT Introduction: Symmetry is balance, some correspondence in the size, form, and arrangements of parts on opposite sides of a plane, line, or point. The opposite of this concept is asymmetry, or imbalance. Objective: This retrospective study compared two methods for assessing arch symmetry with linear measurements based on triangles, to determine their applicability and efficiency. Methods: Two groups were enrolled: children (n=20) and adults (n=20), and the arch symmetry was assessed from linear measurements. Method 1: the incisor-canine (INC), canine-molar (CM), and incisor-molar (INM) distances (paired t-test and Pearson correlation). Method 2: a mathematical equation between the cusps measurements of the canines and the distobuccal of the first molars leading to result 1 (t-test for one sample and bootstrapping analysis). Dental casts were digitized and analyzed using a software program. The Bland-Altman test compared the methods (α=0.05). Results: The Bland-Altman test revealed concordance between the methods; however, separately the results were different: In method 1, the mandibular arch did not demonstrate correlation (children, INC r=0.33; CM r=0.45; INM r=0.51; adults, CM r=0.46; INM r=0.35), however, the maxilla revealed a strong correlation in children and a strong/moderate correlation in adults. In method 2, both arches were symmetrical (p>0.05). Conclusion: Method 1 may be appropriate during orthodontic treatment, and method 2 may be indicated for final treatment. These methods are useful; however, only method 1 identified the side of asymmetry. The methods can contribute to future studies in syndromic and non-syndromic patients, before and after orthognathic surgeries and orthodontic treatment, comparing results. Introduction balance size form plane line point asymmetry imbalance Objective triangles efficiency Methods enrolled n=20 n20 n 20 (n=20 n=20, , incisorcanine incisor canine INC, (INC) caninemolar molar CM, (CM) incisormolar (INM paired ttest t correlation. . correlation) analysis. analysis analysis) program BlandAltman Bland Altman α=0.05. α005 α α=0.05 0 05 (α=0.05) Results however different children, (children r=0.33 r033 r 33 r=0.45 r045 45 r=0.51 r051 51 r=0.46 r046 46 r=0.35, r035 r=0.35 35 r=0.35) strongmoderate moderate p>0.05. p005 p p>0.05 (p>0.05) Conclusion treatment useful nonsyndromic non patients n=2 n2 (n=2 (INC (CM α00 α=0.0 (α=0.05 r=0.3 r03 3 r=0.4 r04 4 r=0.5 r05 5 p00 p>0.0 (p>0.05 n= (n= α0 α=0. (α=0.0 r=0. r0 p0 p>0. (p>0.0 (n α=0 (α=0. r=0 p>0 (p>0. α= (α=0 r= p> (p>0 (α= (p> (α (p

Abstract: This cross-sectional observational study aimed to evaluate and compare facial metrics in women aged 20–65 years using a three-dimensional (3D) stereophotogrammetry system and to establish standardized values for facial metric variations in different age subgroups. This study included 84 Caucasian women divided into two groups based on their age: group 1 (G1) included women aged 20–40 years and group 2 (G2) included women aged 41–65 years. Twenty-one morphometric points on the face were identified, and the facial images were captured using a 3D stereophotogrammetry system, Twenty-three linear measures and 12 angular measures were evaluated, revealing statistically significant differences in 11 linear and 5 angular measures between the groups. In the G2 group, nasal and mouth width, lip philtrum height, Tragus-Nasion and Tragus-Pronasale lengths were increased, along with increased nasofrontal angle, decreased palpebral fissure inclination, and lip vermilion angles. However, palpebral fissure width and height, binocular width, and lip vermilion height were reduced. The aging process in women causes substantial changes in facial features, particularly in the middle and lower thirds of the face. Conversely, no major changes were observed in the upper third of the face. Our study findings provide potential insights for clinicians in developing facial rejuvenation procedures as well as for forensic purposes and surgical planning. The standardized facial metrics values in different age subgroups can guide clinicians in determining appropriate treatment plans for patients seeking facial rejuvenation. Abstract crosssectional cross sectional 2065 20 65 20–6 threedimensional three dimensional D (3D 8 G1 G (G1 2040 40 20–4 (G2 4165 41 41–6 Twentyone Twenty one identified Twentythree evaluated TragusNasion Tragus Nasion TragusPronasale Pronasale angle inclination angles However reduced features Conversely planning 206 6 20– (G 204 4 416 41–

Abstract This study aimed to evaluate the influence of cleft width on dental arch symmetry of children with unilateral cleft lip and palate. Forty-one children were subjected to impression preoperatively (T1; mean age = 0.31 ± 0.07 years) and postoperatively (T2; mean age = 6 .73 ± 1.02 years). Eighty-two digitized dental casts were analyzed by stereophotogrammetry software. The cleft palate width was measured in the anterior (P-P’), middle (M-M’), and posterior (U-U’) regions. Also, the following measurements were obtained: anterior intersegment (I-C’) and intrasegment (I-C); total intersegment (I-T’) and intrasegment (I-T); cleft-side (C’-T’) and non-cleft-side (C-T) canine tuberosity. Paired t test and Pearson correlation coefficient were applied (α = 5%). Cleft width had the following means: 10.16 (± 3.46) mm for P-P’, 12.45 (± 3.00) mm for M-M’, and 12.57 (± 2.71) mm for U-U’. In the longitudinal analysis, I-C’ had a significant reduction, while the other measurements significantly increased (p < 0.001). Asymmetry was verified in the following analyses at T1: I-C’ vs. I-C and I-T’ vs. I-T (p < 0.001); at T2, only in I-C’ vs. I-C (p < 0.001). At T1, P-P’ vs. I-C’ (r = 0.722 and p < 0.001), P-P’ vs. I-T’ (r = 0.593 and p < 0.001), M-M’ vs. I-C’ (r = 0.620 and p < 0.001), and M-M’ vs. I-T’ (r = 0.327 and p < 0.05) showed a positive and significant correlation. At T2, there was a correlation between M-M’ and I-C’ (r = 0.377 and p < 0.05). In conclusion, the anterior and middle cleft widths influenced palatal asymmetry in the first months of life, while middle width influenced residual asymmetry. Fortyone Forty one T1 T (T1 031 0 31 0.3 007 07 0.0 years T2 (T2 73 .7 102 1 02 1.0 years. . Eightytwo Eighty two software PP, PP P , (P-P’) MM, MM M (M-M’) UU U (U-U’ regions Also obtained IC I C (I-C’ (I-C) IT (I-T’ (I-T) cleftside side CT (C’-T’ noncleftside non (C-T tuberosity α 5%. 5 5% 5%) means 1016 10 16 10.1 ( 3.46 346 3 46 1245 12 45 12.4 3.00 300 00 1257 57 12.5 2.71 271 2 71 UU. U-U’ analysis reduction 0.001. 0001 0.001 001 0.001) vs P-P r 0722 722 0.72 0.001, 0593 593 0.59 M-M 0620 620 0.62 0327 327 0.32 0.05 005 05 0377 377 0.37 0.05. conclusion life (T 03 0. 7 1. (P-P’ (M-M’ (U-U (I-C (I-T (C’-T 101 10. 3.4 34 4 124 12. 3.0 30 125 2.7 27 U-U 000 0.00 072 72 0.7 059 59 0.5 062 62 0.6 032 32 037 37 (P-P (M-M 3. 2. 06

Abstract To assess facial changes after oral rehabilitation with complete dentures (CDs) by 3D technology allows understanding the results of a treatment that changes facial proportions. Precise outcome parameters can improve decision making. Objective This descriptive observational research aimed to assess facial changes in completely edentulous patients after oral rehabilitation with a CD by a 3D stereophotogrammetry system. Methodology 30 edentulous patients (7 men and 23 women), aged 50 to 75, were analyzed with stereophotogrammetry at 28 previously determined anthropometric landmarks, at 2 different times: T1, before treatment, and T2, after inserting the CDs. Images were analyzed with a specific software for linear and angular measurements. The paired t-test was used to compare timestamps (α=0.05). Results Major changes were observed in 7 of the 13 linear measures and 7 of the 9 angular measures. The following linear measurements had an increase: Sn-Gn (lower third of the face), Ls-Li (height of the vermilion lip), and ChL-ChR (mouth width). Sn-Ls (nasal philtrum height) decreased. For angular measurements, Sn-St-Pg (lower facial convexity) angles increased, and the Prn-Sn-Ls (nasolabial angle) and GoR-Pg-GoL (mandible convexity) angles decreased. Conclusions Major facial changes in newly rehabilitated edentulous patients with CDs included an increase of the lower third of the face, of the vermilion lip, of mouth width, and of the lower facial convexity, and a decrease of the nasolabial angle and mandible convexity.

Resumo O objetivo deste estudo foi analisar o crescimento e desenvolvimento maxilar de crianças com fissuras orais por meio de um método inovador da técnica de sobreposição 3D-3D. Participaram do estudo crianças com fissura unilateral completa de lábio (FL) e fissura unilateral de lábio e palato (FLP). As moldagens dos arcos dentários foram realizadas 1 dia antes e 1 ano após o reparo cirúrgico labial. Um scanner a laser 3D digitalizou os modelos dentários e o software do sistema de estereofotogrametria analisou as sobreposições 3D-3D em dois grupos correspondentes (mesmo indivíduo, FL e FLP) e um grupo não-correspondente (indivíduos diferentes). As diferenças foram avaliadas pelo Root Mean Square (RMS) e expressas em milímetros (mm). O teste de Kruskal-Wallis seguido do teste post-hoc de Dunn e teste de MannWhitney foram avaliados para comparar os grupos (α=5%). RMS foi de 1.34 mm (± 0.37) no grupo FL, 1.41 mm (± 0.32) no grupo FLP e 3.38 mm (± 1.28) no grupo não-correspondente. RMS foi significativamente maior no grupo não-correspondente (p <0.0001). Não houve diferenças estatisticamente significativas entre os gêneros. A técnica de sobreposição 3D-3D evidenciou o desenvolvimento da maxila após a cirurgia labial na região anterior do palato. Assim, sugere-se que a amplitude da fenda e a proporção dos segmentos palatinos influenciam na heterogeneidade morfológica e, consequentemente, no desenvolvimento e crescimento maxilar de crianças com fissura orofacial

Abstract This study aimed to analyze the maxillary growth and development of children with oral clefts using the innovative method of 3D-3D superimposition technique. Children with unilateral complete cleft lip (UCL) and unilateral cleft lip and palate (UCLP) participated in the study. The impressions of the dental arches were executed 1 day before and 1 year after lip repair surgery. A 3D laser scanner digitized the dental models and the stereophotogrammetry system software analyzed the 3D-3D superimpositions in two groups of matches (same child, UCL and UCLP) and one group of mismatches (different individuals). The differences were evaluated by Root Mean Square (RMS) and expressed in millimeters (mm). Kruskal-Wallis test followed by post-hoc Dunn test and Mann-Whitney test were assessed to compare the groups (α=5%). RMS was 1.34 mm (± 0.37) in UCL group, 1.41 mm (± 0.32) in UCLP group, and 3.38 mm (± 1.28) in mismatches group. RMS was significantly greater in mismatches than in matches groups (p<0.0001). No statistically significant differences occurred between genders. The 3D-3D superimposition technique showed the maxillary development after lip repair surgery in the anterior region of the palate. Thus, it is suggested that the cleft amplitude and the palatal segments proportion influenced the morphological heterogeneity and, consequently, the development and maxillary growth of children with orofacial cleft.

Abstract This study aimed to compare the linear dimensions of the dental arches of adult patients with complete unilateral cleft lip and palate (UCLP) after orthodontic and prosthetic treatment with fixed partial dentures (FPD) to patients without clefts, using 3D technology. This retrospective longitudinal study sample consisted of 35 subjects divided into two groups. Included in this sample were 15 complete UCLP individuals who had received orthodontic treatment before rehabilitation with a fixed partial denture (FG), as well as 20 patients without cleft as control group (CG). All patients were aged between 18 and 30 years. Digital dental casts were obtained in two stages: (T1) end of orthodontic treatment and (T2) one year after prosthetic rehabilitation (FG); and (T1) end of orthodontic treatment and (T2) one year after removal of the orthodontic appliance (CG). Intercanine, interfirst premolar and intermolar distances, and incisor-molar length were obtained. A precalibrated and trained examiner performed the assessments. Intergroup differences between T2 and T1 were compared between the groups using the t test or Mann-Whitney test with a significance level of 5% (p<0.05). The intercanine distance variation (T2-T1) showed statistical difference (p=0.005) increasing in the FG group and decreasing in the CG group. In the interfirst premolar distance variation, FG decreased, while CG increased with statistically significant difference (p=0.008). The intercanine distance of individuals with cleft showed stability, while that of the CG had no stability. The CG showed stability in the interfirst premolar distance, while FG had no stability. These findings showed that the FPD is capable of restricting orthodontic results, leading to a stabilization of the dental arches.

Abstract Objective: To evaluate the facial morphology of Caucasian obese adults in relation to normal weight peers, and to study the association between three-dimensional soft-tissue facial measurements and cardiometabolic risk factors. Material and Methods: Nineteen Caucasian obese subjects aged 25 to 73 years underwent anthropometric measurements, blood samples and a stereophotogrammetric facial scan. Soft-tissue facial linear distances, angles, and volumes were obtained and compared to those collected on normal weight subjects by computing z-scores. Spearman correlation was used to assess the associations between facial measurements and metabolic parameters. Logistic regression analysis adjusted for sex and age was used to assess the risk of metabolic syndrome associated to the facial measurements. Results: Overall, when compared to normal weight persons, obese adults had a wider face in the horizontal dimension, with a middle face (maxilla) that was larger both in absolute value and relatively to the lower face (mandible), and a larger right side gonial angle (Wilcoxon test, p < 0.01). Only the mean (left and right) gonial angle was positively associated to serum triglycerides level, while the other facial measurements were associated with none of the cardiometabolic parameters. Moreover, none of the facial measurements was associated with the risk of metabolic syndrome. Conclusion: Despite larger facial dimensions and altered mandible/maxilla volume ratio, three-dimensional soft-tissue facial morphometry in Caucasian obese adults is not related to cardiometabolic risk factors. The actual association between morphological facial characteristics and clinical information on the health conditions of patients is still to be investigated.

RESUMO O protocolo de avaliação miofuncional orofacial com escores (protocolo AMIOFE) é um instrumento validado para o diagnóstico de distúrbios miofuncionais orofaciais que pode ser utilizado por fonoaudiólogos em sua prática clínica. O presente estudo foi desenvolvido porque não há um instrumento validado para esta finalidade em língua Italiana. Objetivos: traduzir e realizar a adaptação transcultural do protocolo AMIOFE para a língua italiana e determinar os valores dos escores de normalidade em um grupo de jovens e adultos italianos. Métodos: o protocolo AMIOFE foi traduzido da língua inglesa para a italiana por três indivíduos bilíngues. A partir dessas traduções, uma versão de consenso foi preparada por um comitê de pesquisa (três fonoaudiólogos e um médico) e submetida a um comitê de juízes, composto por oito fonoaudiólogos italianos experientes na área. Os autores da versão original verificaram e aprovaram a versão italiana do protocolo. O instrumento foi testado por meio de avaliações de 40 sujeitos italianos jovens e adultos (faixa etária entre 18 e 56 anos de idade), realizadas por dois fonoaudiólogos. O ponto de corte, previamente descrito, foi usado para determinar as médias e desvios-padrão. Resultados: a etapa de tradução e a versão final da versão italiana do protocolo AMIOFE foram apresentadas, bem como as médias dos escores para os sujeitos com e sem distúrbio miofuncional orofacial. Conclusão: a versão italiana do protocolo AMIOFE foi desenvolvida, traduzida e adaptada transculturalmente. Valores de normalidade para sujeitos italianos jovens e adultos foram apresentados.

ABSTRACT The protocol of orofacial myofunctional evaluation with scores (OMES-protocol or AMIOFE in Portuguese language) is a validated instrument for the diagnosis of orofacial myofunctional disorders that can be used in clinical practice for speech-language pathologists. Because in the Italian language there is no validated tool for such purpose, this study was developed. Purposes: To translate and culturally adapt the OMES-protocol for Italian language and determine the normal score value in a group of young Italian adults. Methods: The OMES-protocol was translated from English to Italian by three bilingual individuals. From these translations, a consensus version was prepared by a research committee (three speech therapists and one physician and submitted to a committee of judges composed by eight speech therapists experienced in the area. The authors of the original version verified and approved the Italian version of the protocol. The instrument was tested via evaluations of 40 young and grown-up Italians (age range: 18-56 years) performed by two speech therapists. A cutoff score, previously described, was used to determine the mean and standard deviation. Results: The translation stage and the final Italian version of the OMES-protocol are shown. The mean of scores for individuals with and without orofacial myofunctional disorders were presented. Conclusion: The Italian version of the OMES-protocol was developed, translated, and cross-culturally adapted. Normal values for young and adult Italian subjects are presented.

INTRODUÇÃO: A ginástica é o esporte de habilidades fechadas mais antigo e espetacular. Contudo, parâmetros técnicos de execução geralmente são somente ensinados por treinadores experientes. Desta maneira, existe uma lacuna de informações objetivas sobre o desempenho de ginastas (referências cinemáticas). OBJETIVO: No presente estudo, tentamos quantificar movimentos de inversão linear e de hiperextensão durante a execução de flic flacs. MÉTODOS: Foi efetuada uma detecção não invasiva de flic flacs com o auxílio de um instrumento óptico eletrônico 3D. Treze marcadores esféricos retrorreflexivos (1 cm de diâmetro) foram posicionados no corpo de 9 ginastas experientes: maléolos laterais direito e esquerdo, cabeça da fíbula, trocanter maior, acrômio, olecrano, processo estiloide da ulna e vértex. Na mesma sessão e após um período de aquecimento, cada participante executou 15 repetições de flic flacs. Dez repetições forma analisadas, e os trajetos 3D das 13 manobras medidos. RESULTADOS: Em média, os homens obtiveram altura vertical maior (mulheres, 62% da altura; homens, 58%). O alinhamento dos membros inferiores foi homogêneo entre os ginastas: ângulos posteriores de joelho variaram entre 80° e 118°. Nenhuma abdução de membro inferior foi observada: a largura de joelho foi 7 cm menor do que a largura intertrocanter; a largura de tornozelo foi 8 cm menor do que a largura de joelho. Na saída do movimento, o ângulo tronco-coxa apresentou excelente alinhamento corporal, com valores bem próximos de 180°. As mulheres executaram a fase de apoio das mãos com pulsos mais próximos do que os homens (homens, 134% de largura de ombro; mulheres, 121%). CONCLUSÃO: Os resultados podem fornecer informações para melhor conhecimento, definindo assim, a execução de padrão-ouro obtida de ginastas de elite com poucas lesões.

INTRODUCTION: Gymnastics is the most ancient and spectacular closed skills sport. Nonetheless, technical parameters of performance are often taught only by experienced trainers. Thus, there is a lack of objective data about gymnastics performance (kinematics references). OBJECTIVE: In the current study, we tried to quantify linear and hyperextension back movements during performance of backward handsprings. METHODS: A noninvasive detection of backward handsprings was made using a 3D optoelectronic instrument. Thirteen spherical retro-reflective markers (1-cm diameter) were positioned on the body of 9 experienced gymnasts: right and left lateral malleolus, fibular head, greater trochanter, acromion, olecranon, styloid process of the ulna; vertex. In the same session and after a warm-up period, each participant performed 15 repetitions of backward handsprings. Ten repetitions were analyzed, and the 3D tracks of the 13 landmarks measured. RESULTS: On average, men performed longer backward handsprings than women (men, 122% of height; women, 98%); women attained larger vertical height (women, 62% of height; men, 58%). Lower limb arrangement was homogenous among the gymnasts: posterior knee angles ranged between 80° and 118°. No lower limb abduction was observed: knee width was 7 cm smaller than intertrochanter width; ankle width was 8 cm smaller than knee width. At take-off, the trunk-thigh angle presented excellent body alignment, with values very close to 180°. Women performed the handstand phase with closer wrists than men (men, 134% of shoulder width; women, 121%). CONCLUSION: The results may offer data to improve understanding, defining gold-standard execution taken from high level gymnasts with few injuries.

OBJECTIVES: Zirconia-based prostheses are commonly used for aesthetic crown and fixed restorations, although follow-up data are limited, especially for implant-supported crowns. The aim of this study was to evaluate the threeyear clinical results of the installation of 463 zirconia core crowns by a general dental private practice. METHODS: This study followed 142 patients (69 men and 73 women; aged 28-82 years) who had received 248 single crowns (202 tooth-supported, 36 implant-supported) and 225 multiple units of up to six elements (81 toothsupported, 144 implant-supported). Clinical events, including fracture and loss of retention, secondary caries, and marginal integrity, were recorded. The overall failure rate was computed for the fractured and lost prostheses. Aesthetic, functional, and biological properties were rated, and patient satisfaction was investigated. RESULTS: During the three-year follow-up period, four patients were lost from the study (18 crowns, 4% of the total crowns). Three of the zirconia prostheses suffered fractures in more than three units (11 crowns; one- vs. three-year follow-up, p,0.05, Wilcoxon signed-rank test), and the cumulative prosthesis survival rate was 98.2%. Twelve units lost retention and were re-cemented, and no secondary caries of the abutment teeth were reported. The aesthetic, functional, and biological properties were generally well-rated, and there were no differences between tooth- and implant-supported crowns. The lowest scores were given regarding the anatomical form of the crowns, as some minor chipping was reported. Relatively low scores were also given for the periodontal response and the adjacent mucosa. Overall, patient satisfaction was high. CONCLUSIONS: At the three-year follow-up, the zirconia-core crowns appeared to be an effective clinical solution as they had favorable aesthetic and functional properties. Only the marginal fit of the prostheses should be improved upon.

OBJECTIVES: Functional orthodontic devices can modify oral function thus permitting more adequate growth processes. The assessment of their effects should include both facial morphology and muscle function. This preliminary study investigated whether a preformed functional orthodontic device could induce variations in facial morphology and function along with correction of oral dysfunction in a group of orthodontic patients in the mixed and early permanent dentitions. MATERIAL AND METHODS: The three-dimensional coordinates of 50 facial landmarks (forehead, eyes, nose, cheeks, mouth, jaw and ears) were collected in 10 orthodontic male patients aged 8-13 years, and in 89 healthy reference boys of the same age. Soft tissue facial angles, distances, and ratios were computed. Surface electromyography of the masseter and temporalis muscles was performed, and standardized symmetry, muscular torque and activity were calculated. Soft-tissue facial modifications were analyzed non-invasively before and after a 6-month treatment with a functional device. Comparisons were made with z-scores and paired Student's t-tests. RESULTS: The 6-month treatment stimulated mandibular growth in the anterior and inferior directions, with significant variations in three-dimensional facial divergence and facial convexity. The modifications were larger in the patients than in reference children. In several occasions, the discrepancies relative to the norm became not significant after treatment. No significant variations in standardized muscular activity were found. CONCLUSIONS: Preliminary results showed that the continuous and correct use of the functional device induced measurable intraoral (dental arches) and extraoral (face) morphological modifications. The device did not modify the functional equilibrium of the masticatory muscles.