RESUMO A síndrome de Melkersson-Rosenthal constitui uma manifestação rara caracterizada por uma tríade de sinais e sintomas: edema orofacial recorrente, língua fissurada e paralisia facial recorrente. A dificuldade no diagnóstico da síndrome de Melkersson-Rosenthal é que o edema orofacial é comum a diversas doenças, além do desconhecimento da síndrome pelos profissionais de saúde e da frequente manifestação metacrônica de sua sintomatologia. O objetivo deste relato é apresentar um caso clássico de síndrome de Melkersson-Rosenthal e sua abordagem clínica e terapêutica. Paciente procurou atendimento no Ambulatório de Estomatologia apresentando manifestação sincrônica da tríade: edema não depressível em lábio e bochecha esquerdos acompanhado de paralisia facial do mesmo lado e língua fissurada. A síndrome de Melkersson-Rosenthal foi diagnosticada devido à presença da tríade de sinais e sintomas após a exclusão inicial de doença de Crohn, sarcoidose e tuberculose por ausência de queixas intestinais ou respiratórias e ausência de outras evidências clínicas. O tratamento administrado foi o esteroide, sendo o tratamento mais comum com prognóstico satisfatório que encontramos na literatura para pacientes com SRM. Recomendamos a aplicação de injeções intralesionais de dipropionato de betametasona, pois após quatro infiltrações o edema cedeu em 80% sem novas recidivas em um ano de seguimento. MelkerssonRosenthal Melkersson Rosenthal recorrente doenças sintomatologia terapêutica Crohn clínicas esteroide SRM betametasona 80 seguimento 8

ABSTRACT The Melkersson-Rosenthal syndrome constitutes a rare manifestation characterized by a triad of signs and symptoms: recurrent orofacial edema, fissured tongue, and recurrent facial paralysis. The difficulty in diagnosing Melkersson-Rosenthal syndrome is that orofacial edema is common to various diseases besides the lack of awareness of the syndrome by health professionals and the frequent metachronous manifestation of its symptomatology. The aim of this report is to present a classical case of Melkersson-Rosenthal syndrome and its clinical and therapeutic approach. A patient who sought for assistance at the Stomatology Clinic presented a synchronous manifestation of the triad: a left lip and cheek nonpitting edema accompanied by facial paralysis on the same side and fissured tongue. Melkersson-Rosenthal syndrome was diagnosed due to the presence of the triad of signs and symptoms after initially ruling out Crohn’s disease, Sarcoidosis, and tuberculosis due to a lack of intestinal or respiratory complaints and absence of other clinical evidence. The treatment administered was steroids, the most common treatment with a satisfied prognosis we found in the literature for Melkersson-Rosenthal syndrome patients. We recommend its implementation intralesional injections of betamethasone dipropionate as after four infiltrations the edema subsided by 80% with no further relapses within one-year follow-up. MelkerssonRosenthal Melkersson Rosenthal tongue symptomatology approach Crohns Crohn s disease Sarcoidosis evidence steroids patients 80 oneyear one year followup. followup follow up. up follow-up 8

Resumen Introducción: las bicicletas son un medio de transporte popular que trae beneficios para la salud cuando son utilizadas regularmente. Sin embargo, son frecuentes los accidentes que se presentan en sus usuarios. El objetivo de este trabajo fue evaluar la prevalencia de accidentes y el uso de equipos de protección individual (EPI) en usuarios de bicicletas en São Paulo (Brasil), por medio de formularios. Además, la población estudiada fue orientada sobre la importancia del uso de EPI. Materiales y métodos: ciclistas de diferentes regiones de São Paulo respondieron a las preguntas hechas en un formulario y fueron orientados al correcto uso de los EPI. Resultados: la muestra total fue de 608 personas, evaluadas y entrevistadas (210 mujeres y 398 hombres). El porcentaje mayor de entrevistados tenía entre 20-40 años. Los EPI más usados fueron casco, tenis y señalización de pedales. 48 % de los encuestados dijo que había sufrido accidentes usando este medio de transporte. Gran parte de los accidentes ocurrieron en momentos de ocio, durante las mañanas y en días de sol. 69.5 % de las personas entrevistadas escucharon las indicaciones. Conclusiones: la mayoría de los ciclistas de la ciudad de São Paulo son jóvenes, varones y no utilizan los EPI obligatorios. Los accidentes sufridos, relatados por la población encuestada, no estuvieron relacionados con las condiciones meteorológicas, ni con el consumo de alcohol. En este estudio se observó que solo los ciclistas que ya usaban los EPI estaban interesados en las directrices sobre su importancia y uso correcto.

Abstract Introduction: Bikes are a popular means of transportation that brings health benefits when used regularly. However, accidents occurring in the users of this means of transport are frequent. The objective of this study was to evaluate the prevalence of accidents and the use of Personal protective equipment (PPE) in bicycle users in Sao Paulo (Brazil) through the forms. In addition, the population studied was oriented to the importance of the use of PPE. Materials and methods: Cyclists from different regions of Sao Paulo responded to the form on the PPE and in the end were oriented on the correct use of the PPE. Results: The total sample was 608 people, evaluated and interviewed (210 women and 398 men). The highest percentage of respondents was 20-40 years. The most used PPE were helmet, tennis and pedal signaling. 48 % of respondents said they had already suffered an accident with this means of transport. Most of the accidents occurred in leisure times, during the mornings of sunny days. 69.5 % of respondents heard the guidelines on the correct use of PPE. Conclusions: Most cyclists in the city of Sao Paulo are young, male and do not use the PPE. The accidents suffered, using as a means of transport the bicycle, reported by the reporting population, were not related to the weather conditions, nor with the consumption of alcohol. In this study it was observed that only cyclists who were already using PPE were interested in the guidelines on their importance and correct use.

Resumo Introdução: as bicicletas são um meio de transporte popular que traz benefícios para a saúde quando são utilizadas regularmente. No entanto, são frequentes os acidentes que se apresentam nos usuários deste meio de transporte. O objetivo deste trabalho foi avaliar a prevalência de acidentes e o uso de equipamentos de proteção individual (EPI) em usuários de bicicletas em São Paulo (Brasil) através de formulários. Para além disso, a população estudada foi orientada sobre a importância do uso de EPI. Materiais e métodos: ciclistas de diferentes regiões de São Paulo (Brasil) responderam às perguntas feitas no formulário e no final do estudo foram orientados ao correto uso dos EPI. Resultados: a amostra total foi de 608 pessoas, avaliadas e entrevistadas, sendo 210 mulheres e 398 homens. A maior porcentagem de entrevistados tinha entre 20 e 40 anos. Os EPI mais usados foram: capacete, sapatilhas e sinalização de pedais. 48 % dos inqueridos disseram que já tinham sofrido acidentes usando este meio de transporte. Grande parte dos acidentes ocorreram em momentos de ócio, durante as manhãs, em dias de sol e com pista seca. 69.5 % das pessoas entrevistadas ouviram as indicações. Conclusões: a maioria dos ciclistas da cidade de São Paulo (Brasil) são jovens, varões e não utilizam os EPI obrigatórios. Os acidentes sofridos, usando como meio de transporte a bicicleta, relatados pela população enquerida, não estiveram relacionados com as condições meteorológicas, nem com o consumo de álcool. Neste estudo se observou que só os ciclistas que já usavam os EPI estavam interessados nas diretrizes sobre a sua importância e uso correto.

Abstract INTRODUCTION: Acrylic resins are used in the preparation of facial prostheses and may be colonized by fungi. Here, we verified the antifungal efficacy of this material after surface treatment using poly (diallyldimethylammonium chloride). METHODS: Acrylic resin specimens with and without surface treatment were subjected to tests for fungistatic and fungicidal activities. Standard strains of Candida albicans and Aspergillus niger were used. RESULTS: After surface treatment, the fungistatic and fungicidal efficacies of the resins against C. albicans and fungistatic action against A. niger were verified. CONCLUSIONS: The surface treatment was a determinant of the antifungal activity of the material.

Abstract Objective: To evaluate the inclusion capacity and bactericidal efficiency of diallyl dimethyl ammonium chloride (PDADMAC) diluted in tetrahydrofuran (THF) upon inclusion in the medical grade silicone polymer structure. Material and Methods: It was diluted the PDADMAC in THF at the concentration of 4wt%. It was included in the silicon paste during its vulcanization process. The contact angle measurements were performed to evaluate whether the biocide inclusion into the silicon paste was successful. All samples were sterilized with gamma radiation at 25KGy-dosage prior to the microbiological tests. Microbiological testing strictly followed the Antibacterial products - Test for antibacterial activity and efficacy JIS Z 2801: 201010 and the used of specific bacteria, as Staphylococcus aureus ATCC 6538P and Escherichia coli ATCC 8739. Results: The results showed that PDADMAC, when dissolved in THF at 4wt%, displayed good incorporation in medical silicone and a broad-spectrum antibacterial response. The results of the tests using Escherichia coli ATCC 8739 and Staphylococcus aureus ATCC 6538P showed that the silicone with no biocide addition did not present antibacterial activity. In contrast, the experimental group plus 2 mL of PDADMAC would have an ideal antibacterial response. Conclusion: Medical grade silicone can be used as a material with antibacterial properties, since it has been able to keep PDADMAC compound attached to its structure, thus acquiring antimicrobial property.