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ABSTRACT Dopamine agonists are the first line of treatment for patients with symptomatic hyperprolactinemia due to prolactinomas and in those with idiopathic hyperprolactinemia. Treatment with these agents is effective in 80%-90% of the cases. Infertility treatment of patients with hyperprolactinemia is also carried out with dopamine agonists, aiming for the normalization of prolactin levels. The risk of symptomatic growth of prolactinomas during pregnancy is dependent on the tumor's size, duration of previous treatments, and prolactin levels. Notably, the corresponding risk is relatively low in cases of microprolactinomas (<5%). Remission of hyperprolactinemia occurs in about 30% of the patients after drug treatment and may also occur after pregnancy and menopause. The use of some drugs, such as antidepressants and antipsychotics, is a frequent cause of hyperprolactinemia, and managing this occurrence involves unique considerations. This position statement by the Brazilian Federation of Gynecology and Obstetrics Associations (Febrasgo) and Brazilian Society of Endocrinology and Metabolism (SBEM) addresses the recommendations for measurement of serum prolactin levels and the investigations of symptomatic and asymptomatic hyperprolactinemia and drug-induced hyperprolactinemia in women. 80%90% 8090 80% 90% 80 90 80%-90 tumors tumor s size treatments Notably <5%. 5 <5% . (<5%) 30 menopause drugs antipsychotics considerations Febrasgo (Febrasgo SBEM (SBEM druginduced induced women 80%90 809 8 9 80%-9 <5 (<5% 3 80%9 80%- < (<5 (< (

https://doi.org/10.20945/2359-4292-2023-0504

Diagnosis of hyperprolactinemia in women: A Position Statement from the Brazilian Federation of Gynecology and Obstetrics Associations (Febrasgo) and the Brazilian Society of Endocrinology and Metabolism (SBEM) women Febrasgo (Febrasgo SBEM (SBEM
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Glezer, Andrea

; Garmes, Heraldo Mendes

; Kasuki, Leandro

; Martins, Manoel

; Elias, Paula Condé Lamparelli

; Nogueira, Vania dos Santos Nunes

; Rosa-e-Silva, Ana Carolina Japur de Sá

; Maciel, Gustavo Arantes Rosa

; Benetti-Pinto, Cristina Laguna

; Nácul, Andrea Prestes

Archives of Endocrinology and Metabolism

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2024, Volume 68 elocation e230502

Abstract: En | Text: En | PDF: En

ABSTRACT Hyperprolactinemia is a frequent cause of menstrual irregularity, galactorrhea, hypogonadism, and infertility. The most common etiologies of hyperprolactinemia can be classified as physiological, pharmacological, and pathological. Among pathological conditions, it is essential to distinguish prolactinomas from other tumors and pituitary lesions presenting with hyperprolactinemia due to pituitary stalk disconnection. Proper investigation considering clinical data, laboratory tests, and, if necessary, imaging evaluation, is important to identify the correct cause of hyperprolactinemia and manage the patient properly. This position statement by the Brazilian Federation of Gynecology and Obstetrics Associations (Febrasgo) and Brazilian Society of Endocrinology and Metabolism (SBEM) addresses the recommendations for measurement of serum prolactin levels and the investigations of symptomatic and asymptomatic hyperprolactinemia and medication-induced hyperprolactinemia in women. irregularity galactorrhea hypogonadism infertility physiological pharmacological conditions disconnection data tests necessary evaluation properly Febrasgo (Febrasgo SBEM (SBEM medicationinduced medication induced women

https://doi.org/10.20945/2359-4292-2023-0502

Exercícios de leitura pessoal em livros escolares do Brasil e de Portugal
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Sá, Ana Paula dos Santos de

; Leite, Carlinda

Revista Brasileira de Estudos Pedagógicos

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2024, Volume 105 elocation e5750

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

Resumo: O artigo analisa a frequência e o modo como a leitura pessoal é trabalhada no eixo literário de livros escolares do Brasil e de Portugal. O corpus foi constituído por 73 exercícios de compreensão textual pertencentes a dois manuais de Português do 4º ano da escolaridade básica, sendo um exemplar de cada país. A análise, fundamentada na técnica de análise de conteúdo, foi composta pelas etapas de mapeamento e de categorização das amostras, e seus resultados foram discutidos quantitativa e qualitativamente. Os resultados apontam que são pouco frequentes exercícios que solicitam a expressão da subjetividade. Em ambos os casos, são preponderantes atividades de viés pessoal centradas no gosto, na concordância/discordância e na emissão de opinião, sendo raramente propostas questões sobre a identificação/não identificação com o texto. O maior ponto de divergência entre o manual brasileiro e o português diz respeito ao lugar ocupado pelas perguntas pessoais na sequência didática, o que suscitou reflexões sobre as implicações de se promover a expressão da subjetividade antes e/ou após a leitura. Resumo Portugal 7 º básica país conteúdo amostras qualitativamente casos gosto concordânciadiscordância concordância discordância opinião identificaçãonão não texto didática eou ou

Abstract: The study analyzes the incidence and the manner in which personal reading is covered by the literature sections of textbooks from Brazil and Portugal. The corpus consisted of 73 reading comprehension exercises belonging to two Portuguese language manuals, one from each country, of the 4th year of basic education. Grounded on content analysis, the study comprised mapping and categorization of the samples, while the results were organized and discussed quantitatively and qualitatively. The results indicate that exercises requiring subjectivity are lacking. In both cases, personal reading activities focused on taste, agreement/disagreement and expression of opinion are preponderant. On the other hand, questions regarding the identification/non-identification with the text are rarely proposed. The largest point of contention between the Brazilian and Portuguese textbooks concerns the role filled by personal questions in the didactic sequence, which raised reflections over the implications of promoting subjectivity before and/or after reading. Abstract Portugal 7 manuals country th education analysis samples qualitatively lacking cases taste agreementdisagreement agreement disagreement preponderant hand identification/nonidentification identificationnonidentification identification/non identification non proposed sequence andor or nonidentification identificationnon

Resumen: El artículo analiza la frecuencia y la forma en que se trabaja la lectura personal en las secciones de literatura de libros de texto de Brasil y Portugal. El corpus se compuso de 73 ejercicios de comprensión textual pertenecientes a dos libros de texto de Lengua Portuguesa del 4º grado de enseñanza básica, uno de cada país. El análisis, basado en la técnica de análisis de contenido, consistió en las etapas de mapeo y categorización de las muestras, y sus resultados se discutieron cuantitativa y cualitativamente. Los resultados indican que los ejercicios que solicitan la expresión de la subjetividad son poco frecuentes. En ambos casos, son preponderantes las actividades de lectura personal centradas en el gusto, el acuerdo/desacuerdo y la emisión de opinión, y rara vez se proponen preguntas sobre la identificación/no identificación con el texto. El mayor punto de divergencia entre los manuales brasileño y portugués se refiere al lugar ocupado por las preguntas personales en la secuencia didáctica, lo que suscitó reflexiones sobre las implicaciones de promover la expresión de la subjetividad antes y/o después de la lectura. Resumen Portugal 7 º básica país contenido muestras cualitativamente frecuentes casos gusto acuerdodesacuerdo acuerdo desacuerdo opinión identificaciónno no didáctica yo o

https://doi.org/10.24109/2176-6681.rbep.105.5750

Hyperprolactinemia in women: diagnostic approach women
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Glezer, Andrea

; Garmes, Heraldo Mendes

; Kasuki, Leandro

; Martins, Manoel

; Elias, Paula Condé Lamparelli

; Nogueira, Vania dos Santos Nunes

; Rosa-e-Silva, Ana Carolina Japur de Sá

; Maciel, Gustavo Arantes Rosa

; Benetti-Pinto, Cristina Laguna

; Nácul, Andrea Prestes

Revista Brasileira de Ginecologia e Obstetrícia

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2024, Volume 46 elocation e-FPS04

Abstract: En | Text: En | PDF: En

https://doi.org/10.61622/rbgo/2024fps04

Sexual counseling for people with acute coronary syndrome: educational video development syndrome
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Andrade, Laura Rizardi dos Santos

; Anjos, Lanay Dourado dos

; Aguiar, Ana Paula Freitas

; Lima, Edvone Alves de

; Abuchaim, Erika de Sá Vieira

; Lopes, Juliana de Lima

; Lopes, Camila Tákao

; Santos, Vinicius Batista

Revista Brasileira de Enfermagem

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2024, Volume 77 N. 3 elocation e20230416

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

RESUMO Objetivo: avaliar as evidências de validade de um vídeo educativo sobre atividade sexual segura após síndrome coronariana aguda. Método: estudo em três fases: desenvolvimento de um vídeo; análise da validade de conteúdo por 11 especialistas; e análise da validade baseada nos processos de resposta por sete pessoas com doença coronariana. Calculou-se a razão de validade de conteúdo (CVR) com valores críticos para a segunda fase de 0,63 e para a terceira de 1,0. Resultados: o vídeo abordou a importância da retomada da atividade sexual e das posições que consomem menos energia, sinais clínicos de alerta, importância da adesão ao tratamento e do ambiente acolhedor para prática sexual. Obteve-se um CVR acima do valor crítico com um total de 4 minutos e 41 segundos. Conclusão: o vídeo educacional reúne adequadas evidências de validade de conteúdo, podendo ser utilizado como uma ferramenta para pacientes após síndrome coronariana aguda. Objetivo aguda Método fases 1 especialistas Calculouse Calculou se (CVR 063 0 63 0,6 10 1,0 Resultados energia alerta Obtevese Obteve segundos Conclusão 06 6 0, 1,

ABSTRACT Objective: to assess validity evidence of an educational video on safe sexual activity after acute coronary syndrome. Method: study in three phases: video development; content validity analysis by 11 experts; and analysis of validity based on response processes by seven people with coronary disease. The content validity ratio (CVR) was calculated with critical values for the second phase of 0.63 and for the third of 1.0. Results: the video addressed the importance of resuming sexual activity and positions that consume less energy, clinical warning signs, the importance of adhering to treatment and a welcoming environment for sexual practice. A CVR above the critical value was obtained with a total of 4 minutes and 41 seconds. Conclusion: the educational video brings together adequate content validity evidence and can be used as a tool for patients after acute coronary syndrome. Objective syndrome Method phases development 1 experts disease (CVR 063 0 63 0.6 10 1.0 Results energy signs practice seconds Conclusion 06 6 0. 1.

RESUMEN Objetivo: evaluar la evidencia de validez de un video educativo sobre actividad sexual segura después del síndrome coronario agudo. Método: estudio en tres fases: elaboración de un vídeo; análisis de validez de contenido por 11 expertos; y análisis de validez basado en procesos de respuesta de siete personas con enfermedad coronaria. Se calculó el índice de validez de contenido (CVR) con valores críticos para la segunda fase de 0,63 y para la tercera de 1,0. Resultados: el video abordó la importancia de retomar la actividad sexual y posiciones que consuman menos energía, signos de alerta clínica, la importancia de adherirse al tratamiento y un ambiente acogedor para la práctica sexual. Se obtuvo un CVR por encima del valor crítico con un total de 4 minutos y 41 segundos. Conclusión: el video educativo reúne evidencia adecuada de validez de contenido y puede ser utilizado como herramienta para pacientes post síndrome coronario agudo. Objetivo agudo Método fases vídeo 1 expertos coronaria (CVR 063 0 63 0,6 10 1,0 Resultados energía clínica segundos Conclusión 06 6 0, 1,

https://doi.org/10.1590/0034-7167-2023-0416

Analysis of the pedigree of the Mangalarga breed: Population structure and genetic diversity breed
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Maciel, Michael dos Santos

; Lucena, Jorge Eduardo Cavalcante

; Pinto, Ana Paula Gomes

; Nascimento, Caline Angélica de Menezes Sá

; Arandas, Janaina Kelli Gomes

; Rocha, Laura Leandro da

; Santiago, Juliano Martins

Revista Brasileira de Zootecnia

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2024, Volume 53 elocation e20230122

Abstract: En | Text: En | PDF: En

ABSTRACT This study used a pedigree analysis to monitor trends in the genetic structure of the Mangalarga breed and identify factors that could impact its genetic variability. For this, genealogical information was used from the Associação Brasileira dos Criadores de Cavalo da Raça Mangalarga, considering as total population (TP) the animals born between 1919 and 2018 (n = 206,426) and as reference population (RP) those born between 2009 and 2018 (n = 20,539), which is the most recent generation according to the average generation interval calculated for the breed of 9.37 years. We evaluated the number of male and female births per year, foals produced by Mangalarga breeding animals, using the ENDOG 4.8, generation interval, proportion of known ancestors per parental generation, number of equivalent generations known per animal, inbreeding coefficient, increase in inbreeding, average relatedness (AR), effective population size, effective number of founders, effective number of ancestors, and founder genome equivalent. The number of equivalent generations known per animal increased over time, reaching an average of 2.75 in TP and 4.88 in RP. The calculated F was 2.26% for TP and 5.57% for RP, while AR was 2.41% for TP and 4.10% for RP. The effective population size was 40.85 for TP and 38.89 for RP. The 206,426 registered Mangalarga horses (TP) were derived from the genetic contribution of 9,011 founders and 8,908 ancestors, whereas those registered in or after 2009 (RP) originated from 2,662 founders and 2,193 ancestors. The effective number of founders represented 1.11 and 1.35% of the total number of founders in TP and RP, respectively. For RP, 11 animals accounted for 29.21% of the genetic pool of the breed. The analysis of population parameters estimated in the present study indicates that the Mangalarga horse population was formed through uneven contributions from founders and ancestors; therefore, genetic management of the breed is required to restrict average inbreeding from increasing over generations. variability this (TP 191 201 n 206426 206 426 RP (RP 200 20,539, 20539 20,539 , 20 539 20,539) 937 9 37 9.3 years year 48 4 8 4.8 coefficient AR, (AR) time 275 2 75 2.7 488 88 226 26 2.26 557 5 57 5.57 241 41 2.41 410 10 4.10 4085 40 85 40.8 3889 38 89 38.8 206,42 9011 011 9,01 8908 908 8,90 2662 662 2,66 2193 193 2,19 111 1 1.1 135 35 1.35 respectively 2921 29 21 29.21 therefore 19 20642 42 2053 20,53 53 93 3 9. 4. (AR 27 7 2. 22 2.2 55 5.5 24 2.4 4.1 408 40. 388 38. 206,4 901 01 9,0 890 90 8,9 266 66 2,6 219 2,1 1. 13 1.3 292 29.2 2064 205 20,5 5. 206, 0 9, 8, 6 2, 29. 20,

https://doi.org/10.37496/rbz5320230122

Uso da Hermenêutica Objetiva em pesquisas sobre livros didáticos
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Sá, Ana Paula dos Santos de

; Gomes, Luiz Roberto

Educar em Revista

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2024, Volume 40 elocation e90361

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO O objetivo do artigo é aproximar o aporte teórico-epistemológico da Hermenêutica Objetiva (HO) das análises de livros didáticos. Compõe o corpus de pesquisa uma coleção de Português do Ensino Médio aprovada pelo Programa Nacional do Livro Didático em 2018. Com base nos princípios da HO, foram desenvolvidas análises qualitativas junto a uma equipe multidisciplinar de pesquisadores da área de Educação. Os resultados indicam que o uso do método é adequado aos estudos sobre a materialidade textual dos livros escolares, visto que possibilita a identificação de contradições estabelecidas entre o livro didático e seus referenciais internos (Manual do Professor e gabaritos) e externos (documentos oficiais), assim como uma melhor compreensão do papel exercido por paratextos e elementos iconográficos. teóricoepistemológico teórico epistemológico HO (HO didáticos 2018 Educação escolares Manual gabaritos documentos oficiais, oficiais , oficiais) iconográficos 201 20 2

ABSTRACT The article aims to approach the theoretical-epistemological contribution of Objective Hermeneutics (OH) to research on textbooks. To this end, we analyzed a high school Portuguese language textbook approved by the national school textbook plan in 2018. Based on the principles of HO, qualitative analyses were developed with a multidisciplinary team from the field of Education. The results reveal that the use of the method is appropriate for research on textbooks, since it enables the identification of contradictions established between the textbook and its internal (Teacher’s Book and Answer keys) and external (official documents) referentials, as well as a better understanding of the role played by paratexts and iconographic elements. theoreticalepistemological theoretical epistemological OH (OH textbooks end 2018 HO Education Teachers Teacher s keys official documents referentials elements 201 20 2

https://doi.org/10.1590/1984-0411.90361

Diagnosis of the production chain of flowers, turfgrass, and ornamental plants: proposal for an innovation agenda flowers turfgrass plants
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Paiva, Patricia Duarte de Oliveira

; Castro, Ana Cecília Ribeiro

; Geest, Ana Paula Sá Leitão Van Der

; Vieira, Gustavo Franco Rosa

; Hummel, Milton

; Lopes, Henrique dos Santos

; Costa, Jefferson Luis da Silva

Ornamental Horticulture

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2024, Volume 30 elocation e242792

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo As Câmaras Setoriais e Temáticas são fóruns de diálogo criados pelo Ministério da Agricultura e Pecuária (MAPA), por meio dos quais se busca uma maior interação com as cadeias produtivas, bem como a identificação de oportunidades e a definição de ações prioritárias para o desenvolvimento da agricultura brasileira. As Câmaras Temáticas podem contribuir para o desenvolvimento da agricultura identificando demandas do setor produtivo e vinculando-as a propostas de pesquisa, desenvolvimento e inovação, criando agendas de inovação. Para isso, a análise das cadeias produtivas e suas práticas permite uma melhor compreensão do agronegócio, o que, consequentemente, possibilita o desenvolvimento de estratégias eficazes para promover o crescimento e desenvolvimento do setor. O objetivo de uma agenda em Flores, Gramas e Plantas Ornamentais é apresentar uma análise dos principais problemas e oportunidades de inovação nas cadeias produtivas. Um diagnóstico da situação atual, focado em uma visão para o futuro, foi necessário para a construção desta Agenda de Inovação. A abordagem metodológica foi dividida e conduzida por meio de diferentes análises: a) Análise da evolução do Mercado de Flores e Plantas Ornamentais; b) Análise das contribuições, impacto e expectativas dos elos da cadeia produtiva; c) Mapeamento do capital humano na ciência brasileira com potencial para contribuir com inovações tecnológicas para o mercado de flores, gramas e plantas ornamentais. A Agenda de Inovação prioriza os obstáculos mais relevantes, estabelece seu nível de importância e identifica dez Desafios de Inovação significativos a serem abordados pelos setores público e privado do país. Por meio da agenda, ações estratégicas são sugeridas para pesquisa, transferência de tecnologia e políticas públicas, essenciais para o desenvolvimento tecnológico do setor, sem negligenciar sua sustentabilidade socioeconômica e ambiental. Para cada Desafio de Inovação, foram sugeridas Ações Estratégicas a serem perseguidas, e o Brasil possui a competência técnica distribuída por todo o país, em universidades e institutos de pesquisa e empresas reconhecidas nacionalmente. MAPA, MAPA , (MAPA) vinculandoas vinculando isso agronegócio que consequentemente atual futuro análises b contribuições produtiva c flores ornamentais relevantes país públicas ambiental perseguidas nacionalmente (MAPA

Abstract Sectoral and Thematic Chambers are forums for dialogue created by the Ministry of Agriculture and Livestock (MAPA), through which greater interaction with productive chains is sought, as well as the identification of opportunities and the definition of priority actions for developing Brazilian agriculture. The Thematic Chambers can contribute to the development of agriculture by identifying demands from the productive sector and linking them to proposals for research, development, and innovation by creating innovation agendas. For that, the analysis of productive chains and their practices allows a better understanding of agribusiness, which consequently enables the development of effective strategies to promote the growth and development of a sector. The objective of the agenda in Flower, Turfgrass, and Ornamental Plant is to present an analysis of the main problems and opportunities for innovation in the productive chains. A diagnosis of the current situation focusing on a vision for the future was required to prepare this Innovation Agenda. The methodological approach was divided and conducted through different analyses: a) Analysis of the evolution of the Flower and Ornamental Plant Market; b) Analysis of contributions, impact, and expectations of the links in the production chain; c) Mapping of human capital in Brazilian science with the potential to contribute to technological innovations for the market of flowers, grasses, and ornamental plants. The Innovation Agenda prioritizes the most relevant obstacles, establishes their level of importance, and identifies ten significant Innovation Challenges to be addressed by the public and private sectors of the country. Through the agenda, strategic actions are suggested for research, technology transfer, and public policies, which are essential for the technological development of the sector, without neglecting its socioeconomic and environmental sustainability. For each Innovation Challenge, Strategic Actions were suggested to be pursued, and Brazil has the technical competence distributed across the country, in nationally recognized universities and research institutes and enterprises. MAPA, MAPA , (MAPA) sought agendas that agribusiness Turfgrass analyses Market b contributions impact chain c flowers grasses plants obstacles importance country transfer policies sustainability Challenge pursued enterprises (MAPA

https://doi.org/10.1590/2447-536x.v30.e242792

Model Based System Engineering (MBSE) and design assurance process in the context of mitigation of design errors during the development of highly integrated and complex aerospace systems MBSE (MBSE
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WASHIO, DOUGLAS H.

; SOUZA, MARCELO L. DE OLIVEIRA E

; RABELLO, ANA PAULA DE SÁ SANTOS

Anais da Academia Brasileira de Ciências

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2023, Volume 95 Suppl. 2 elocation e20220859

Abstract: En | Text: En | PDF: En

Abstract Over the years, aircraft and spacecraft designs incorporated highly integrated and/or complex systems that can manage complex scenarios during its operation. In addition to the inherent complexity and/or high level of integration of those systems, the development process applied to aerospace programs is also challenged by other factors: program schedule, budget, multidisciplinary teams, new industry emerging technologies, large number of different processes and procedures that guide the activities along the development life cycle, and others. Given the fact many tasks executed during the development of such systems require human interaction, that yields the introduction of design errors that can contribute to the occurrence of non-desired system behaviors during operation phase. It is already recognized by the civil aviation industry that it is unfeasible to have a deterministic test set to demonstrate that such systems are completely free of such design errors. In that context, a huge effort is applied by the industry, by using qualitative methods to mitigate the occurrence of design errors during the development phases. This paper discusses how MBSE methodology applied together with a design assurance process could prevent such design errors, and presents an analysis showing how some events in aerospace industry where a design error was one of the contributing factors could be avoided. years andor or schedule budget teams technologies cycle others interaction nondesired non desired phase context phases avoided

https://doi.org/10.1590/0001-3765202320220859

10.

Chikungunya virus infection in the southernmost state of Brazil was characterised by self-limited transmission (2017-2019) and a larger 2021 outbreak selflimited self limited 20172019 2017 2019 (2017-2019 202 2017201 201 (2017-201 20 201720 (2017-20 2 20172 (2017-2 (2017- (2017 (201 (20 (2 (
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Gregianini, Tatiana Schäffer

; Salvato, Richard Steiner

; Barcellos, Regina Bones

; Godinho, Fernanda Marques

; Ruivo, Amanda Pellenz

; de Melo, Viviane Horn

; Schroder, Júlio Augusto

; Martiny, Fernanda Letícia

; Möllmann, Erica Bortoli

; Favreto, Cátia

; Baethgen, Ludmila Fiorenzano

; Ferreira, Vithoria Pompermaier

; de Lima, Lívia Eidt

; Piazza, Cláudia Fasolo

; Machado, Taís Raquel Marcon

; Becker, Irina Marieta

; Ramos, Raquel Rocha

; Frölich, Guilherme Carey

; Rossetti, Alana Fraga

; Almeida, Lucas da Cunha

; Rodrigues, Tahiana Machado Antunes

; Bragança, Isabella Tabelli

; Campos, Aline Alves Scarpellini

; Manzoni, Verônica Baú

; Machado, Lais Ceschini

; da Silva, Luisa Maria Inácio

; de Oliveira, André Luiz Sá

; Paiva, Marcelo Henrique Santos

; Nunes, Zenaida Marion Alves

; de Almeida, Paula Rodrigues

; Demoliner, Meriane

; Gularte, Juliana Schons

; da Silva, Mariana Soares

; Filippi, Micheli

; Pereira, Vyctoria Malayhka de Abreu Góes

; Spilki, Fernando Rosado

; da Veiga, Ana Beatriz Gorini

; Wallau, Gabriel Luz

Memórias do Instituto Oswaldo Cruz

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2023, Volume 118 elocation e220259

Abstract: En | Text: En | PDF: En

BACKGROUND Chikungunya is a mosquito-borne virus that has been causing large outbreaks in the Americas since 2014. In Brazil, Asian-Caribbean (AC) and East-Central-South-African (ECSA) genotypes have been detected and lead to large outbreaks in several Brazilian states. In Rio Grande do Sul (RS), the southernmost state of Brazil, the first cases were reported in 2016. OBJECTIVES AND METHODS We employed genome sequencing and epidemiological investigation to characterise the Chikungunya fever (CHIKF) burden in RS between 2017-2021. FINDINGS We detected an increasing CHIKF burden linked to travel associated introductions and communitary transmission of distinct lineages of the ECSA genotype during this period. MAIN CONCLUSIONS Until 2020, CHIKV introductions were most travel associated and transmission was limited. Then, in 2021, the largest outbreak occurred in the state associated with the introduction of a new ECSA lineage. CHIKV outbreaks are likely to occur in the near future due to abundant competent vectors and a susceptible population, exposing more than 11 million inhabitants to an increasing infection risk. mosquitoborne mosquito borne 2014 Brazil AsianCaribbean Asian Caribbean AC (AC EastCentralSouthAfrican East Central South African (ECSA states RS, , (RS) 2016 (CHIKF 20172021. 20172021 2017 2021. 2021 2017-2021 period 2020 limited Then lineage population 1 risk 201 (RS 2017202 202 2017-202 20 201720 2017-20 2 20172 2017-2 2017-

https://doi.org/10.1590/0074-02760220259

11.

Leitura subjetiva e livros didáticos de Português: em busca do sujeito-leitor no ensino médio Português sujeitoleitor sujeito leitor
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Sá, Ana Paula dos Santos de

Revista Brasileira de Linguística Aplicada

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2023, Volume 23 N. 4 elocation e18832

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO: O objetivo do artigo é verificar de que modo e em que medida livros didáticos de Português do ensino médio dão espaço à mediação de leituras subjetivas. Trata-se de uma investigação de viés documental e qualitativo, fundamentada em concepções dialógicas de leitura. O corpus é constituído por exercícios do eixo literário de coleções dos PNLDs 2015 e 2018, a partir das quais os dados foram mapeados, classificados e analisados. Os resultados apontam para a baixa incidência de questões de viés pessoal e para uma certa aleatoriedade na formulação dos enunciados das perguntas e dos gabaritos, que torna indistintas questões de viés objetivo e subjetivo. Conclui-se que, embora as coleções anunciem ao professor um alinhamento ao dialogismo, a abertura à expressão da pessoalidade do aluno apresenta inconsistências, pois há o predomínio de atividades que enfatizam um único modo de ler. RESUMO subjetivas Tratase Trata se qualitativo leitura 201 2018 mapeados analisados gabaritos subjetivo Concluise Conclui dialogismo inconsistências ler 20 2

ABSTRACT: The purpose of this article is to verify how and to what extent high school Portuguese textbooks give space to the mediation of subjective readings. This is a documental and qualitative research, based on dialogical conceptions of reading. The corpus consists of exercises of the literature of collections of PNLDs 2015 and 2018, from which the data were mapped, classified and analyzed. The results point to the low incidence of personal type questions and to a certain lack of pattern in the formulation of the objective and subjective questions, which makes both kinds indistinct. We conclude that, although the collections announce to the teacher an alignment to dialogism, the work with students’ subjectiveness presents inconsistencies, because there is a predominance of activities that emphasize a single way of reading. ABSTRACT readings research reading 201 2018 mapped analyzed indistinct dialogism students inconsistencies 20 2

https://doi.org/10.1590/1984-6398202318832

12.

DAS RUAS PARA OS CURRÍCULOS: PRECURSORES SOCIAIS E JURÍDICOS DAS LEIS 10.639/03 E 11.645/08
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SÁ, ANA PAULA DOS SANTOS DE

Educação em Revista

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2021, Volume 37 elocation e20654

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

RESUMO: O objetivo deste artigo é investigar os percursos sociais e jurídicos das leis federais brasileiras nº 10.639/03 e nº 11.645/08 - que tornaram obrigatório o ensino de conteúdos referentes à História e à Cultura afro-brasileira e indígena brasileira em toda a educação básica -, com base na premissa de que políticas dessa natureza alinham-se a um processo de descolonização do sistema educacional. Para tanto, revisamos, comparativamente, discursos e ações da militância negra e indígena no campo da educação, de modo a compreender as motivações e os eventos que antecederam a promulgação de ambas as leis. Nossas conclusões apontam que, a despeito das particularidades das demandas de cada militância - haja vista os esforços do movimento indígena para se desvencilhar da educação ofertada pelo sistema oficial de ensino, enquanto que a população negra, ao contrário, lutava para ter acesso igualitário a esse mesmo sistema -, as duas medidas resultam, em maior ou menor grau, de denúncias e de questionamentos acerca da matriz e/ou do legado colonial que marca, historicamente, os currículos e as escolas brasileiras.

ABSTRACT: The objective of this article is to investigate the social and legal paths of the Brazilian federal laws nº 10.639/03 and nº 11.645/08 - which made mandatory the teaching of content related to Afro-Brazilian and Indigenous Brazilian History and Culture in all basic education - based on the premise that policies of this nature are aligned with a process of decolonization of the educational system. To this end, we comparatively reviewed the discourses and actions of black and indigenous militancy in the field of education in order to understand the motivations and events that preceded the enactment of both laws. Our conclusions point out that, despite the particularities of the demands of each militancy - as seen in the efforts of the indigenous movement to disentangle itself from the education offered by the official school system, while the black population, on the contrary, fought to have equal access to this same system - both measures result, to a greater or lesser extent, from denunciations and questionings about the colonial matrix and/or legacy that historically marks Brazilian curricula and schools.

RESÚMEN: El objetivo de este artículo es investigar los caminos sociales y legales de las leyes federales brasileñas nº 10.639/03 y nº 11.645/08 - que hicieron obligatoria la enseñanza de contenidos relacionados con la Historia y la Cultura Afrobrasileña e Indígena Brasileña en toda la educación básica -, partiendo de la premisa de que tales políticas están alineadas con un proceso de descolonización del sistema educativo. Hemos revisado comparativamente los discursos y acciones de la militancia negra e indígena en el campo de la educación para comprender las motivaciones y los eventos que precedieron a la promulgación de ambas leyes. Nuestras conclusiones señalan que, a pesar de las particularidades de las demandas de cada militancia - ya que el movimiento indígena se esforzaba por deshacerse de la educación ofrecida por el sistema educativo oficial, mientras que la población negra, por otro lado, luchaba por tener un acceso igualitario a este sistema -, las dos medidas resultan, en mayor o menor medida, de las denuncias y cuestionamientos sobre la matriz y/o el legado colonial que marca históricamente los planes de estudio y las escuelas brasileñas.

https://doi.org/10.1590/0102-469820654 108 downloads

13.

Por um cânone escolar antirracista no ensino médio: um olhar aos livros didáticos de Português
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Sá, Ana Paula dos Santos de

Revista Brasileira de Educação

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2021, Volume 26 elocation e260092

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

RESUMO O objetivo deste artigo foi analisar propostas didático-pedagógicas de livros didáticos de Português que, por meio do trabalho com a literatura afro-brasileira, nos permitam verificar caminhos para a construção de uma educação literária de viés antirracista no ensino médio. Com a discussão sobre a necessidade de descolonização do cânone escolar, analisamos o modo como duas coleções aprovadas pelo Programa Nacional do Livro Didático 2015 articulam o poeta afrodescendente Luiz Gama ao condoreirismo. Com base numa investigação qualitativa dessa ocorrência, destacamos os pontos que parecem convergir com uma perspectiva antirracista de ensino e/ou divergir dela. Concluiu-se, com pontuais ressalvas, que os capítulos investigados se alinham a tal perspectiva, sobretudo ao incluírem, ao lado de Gama, autores afrodescendentes contemporâneos e textos que tratam positivamente da ancestralidade africana e da negritude.

ABSTRACT This article aimed to analyze didactic-pedagogical proposals of Portuguese textbooks that suggest ways to reach an antiracist education in Brazilian high school, with attention to the teaching of Afro-Brazilian literature. From a discussion about the need for decolonization of the school canon, it analyzes collections approved by National Textbook Plan (Programa Nacional do Livro Didático - PNLD) 2015 that articulate the afro-descendant poet Luiz Gama to the condoreirismo. Based on a qualitative investigation of this issue, we highlight the points that seem to converge and/or diverge from an antiracist teaching perspective. It is concluded that the chapters investigated dialogue with that perspective, especially because they include contemporary Afro-Brazilians authors and positive texts about African ancestry and blackness, alongside the poetry of Gama.

RESUMEN El objetivo de este artículo fue analizar las propuestas didácticas y pedagógicas de los libros de texto de Portugués que, a través de la literatura afrobrasileña, señalan las formas de construir una educación antirracista en la escuela secundaria. A partir de la discusión sobre la necesidad de descolonización del canon escolar, se analizaron colecciones aprobadas por el Programa Nacional del Livro de Texto (Programa Nacional do Livro Didático - PNLD) 2015 que articulan al poeta Luiz Gama al condoreirismo. Basándonos en una investigación cualitativa, destacamos los puntos que parecen converger y/o divergir desde una perspectiva de enseñanza antirracista. Se concluye que los capítulos investigados se ajustan a esa perspectiva, especialmente al incluir, junto a Gama, autores contemporáneos afrodescendientes y textos que abordan positivamente la ascendencia africana y la negritud.

https://doi.org/10.1590/s1413-24782021260092

14.

Brazilian Nutritional Consensus in Hematopoietic Stem Cell Transplantation: Graft- versus -host disease
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Pereira, Andréa Z

; Vigorito, Afonso Celso

; Almeida, Alessandro de Moura

; Candolo, Alexandre de Almeida

; Silva, Ana Carolina Leão

; Brandão-Anjos, Ana Elisa de Paula

; Sá, Bianca Laselva de

; Souza, Catarina Lôbo Santos de

; Castro Junior, Cláudio Galvão de

; Oliveira, José Salvador Rodrigues de

; Barban, Juliana Bernardo

; Mancilha, Elaine Maria Borges

; Todaro, Juliana

; Lopes, Lilian Pinheiro

; Macedo, Maria Cristina Martins de Almeida

; Rodrigues, Morgani

; Ribeiro, Paulo Cesar

; Silva, Roberto Luiz da

; Roberto, Telma Sigolo

; Rodrigues, Thays de Cássia Ruiz

; Colturato, Vergilio Antonio Rensi

; Paton, Eduardo José de Alencar

; Barros, George Maurício Navarro

; Almeida, Rosana Ducatti Souza

; Moreira, Maria Claudia Rodrigues

; Flowers, Mary Evelyn

einstein (São Paulo)

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2020, Volume 18 elocation eAE4799

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO O Consenso Brasileiro de Nutrição no Transplante de Células Tronco Hematopoiéticas: doença do enxerto contra o hospedeiro foi aprovado pela Sociedade Brasileira de Transplante de Medula Óssea, com a participação de 26 centros brasileiros de transplante de células-tronco hematopoiéticas. O Consenso descreve as principais condutas nutricionais em casos de doença do enxerto contra o hospedeiro, a principal complicação do transplante de células-tronco hematopoiéticas.

ABSTRACT The Brazilian Consensus on Nutrition in Hematopoietic Stem Cell Transplantation: Graft- versus -host disease was approved by Sociedade Brasileira de Transplante de Medula Óssea , with the participation of 26 Brazilian hematopoietic stem cell transplantation centers. It describes the main nutritional protocols in cases of Graft- versus -host disease, the main complication of hematopoietic stem cell transplantation.

https://doi.org/10.31744/einstein_journal/2020ae4799 1552 downloads

15.

Lipase and factor V (but not viral load) are prognostic factors for the evolution of severe yellow fever cases
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Casadio, Luciana Vilas Boas

; Salles, Ana Paula Moreira

; Malta, Fernanda de Mello

; Leite, Gabriel Fialkovitz

; Ho, Yeh-Li

; Gomes-Gouvêa, Michele Soares

; Malbouisson, Luiz Marcelo Sá

; Levin, Anna S

; de Azevedo Neto, Raymundo Soares

; Carrilho, Flair José

; Nastri, Ana Catharina Seixas Santos

; Pinho, João Renato Rebello

Memórias do Instituto Oswaldo Cruz

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2019, Volume 114 elocation e190033

Abstract: En | Text: En | PDF: En

BACKGROUND Despite a highly efficacious vaccine, yellow fever (YF) is still a major threat in developing countries and a cause of outbreaks. In 2018, the Brazilian state of São Paulo witnessed a new YF outbreak in areas where the virus has not been detected before. OBJECTIVE The aim is to describe the clinical and laboratorial characteristics of severe cases of YF, evaluate viral to determine markers associated with fatal outcome. METHODS Acute severe YF cases (n = 62) were admitted to the Intensive Care Unit of a reference hospital and submitted to routine laboratorial evaluation on admission. YFV-RNA was detected in serum and urine by reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and then sequenced. Patients were classified in two groups: survival or death. FINDINGS In the univariate analysis the following variables were associated with outcome: alanin aminotransferase (ALT), aspartat aminotransferase (AST), AST/ALT ratio, total bilirubin (TB), chronic kidney disease epidemiology collaboration (CKD-EPI), ammonia, lipase, factor V, international normalised ratio (INR), lactate and bicarbonate. Logistic regression model showed two independent variables associated with death: lipase [odds ratio (OR) 1.018, 95% confidence interval (CI) 1.007 to 1.030, p = 0.002], and factor V (OR -0.955, 95% CI 0.929 to 0.982, p = 0.001). The estimated lipase and factor V cut-off values that maximised sensitivity and specificity for death prediction were 147.5 U/L [area under the curve (AUC) = 0.879], and 56.5% (AUC = 0.913). MAIN CONCLUSIONS YF acute severe cases show a generalised involvement of different organs (liver, spleen, heart, kidneys, intestines and pancreas), and different parameters were related to outcome. Factor V and lipase are independent variables associated with death, reinforcing the importance of hemorrhagic events due to fulminant liver failure and pointing to pancreatitis as a relevant event in the outcome of the disease.

https://doi.org/10.1590/0074-02760190033 1354 downloads

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