Resumen Introducción: El aumento en el uso de tecnologías de la información y la comunicación, internet y redes so-ciales ha dado lugar a cambios significativos en la forma en que las personas se comunican, lo que conlleva consecuencias negativas que pueden comprometer la salud psicológica y física. El objetivo de este estudio es presentar una adaptación y validación de la Escala General de Phubbing en una población española. Método: Trescientos cuarenta y seis participantes españoles participaron en el estudio completando medidas de autoinforme para evaluar sus niveles de phubbing, adicción a Internet, adicción al teléfono y Fear of Missing Out (FoMO). Resultados: La adaptación de la escala al español resultó en propiedades psicométricas de alta calidad y preservación del número original de ítems y la estructura (nomofobia, con-tacto interpersonal, autoaislamiento y reconocimiento del problema). Además, el análisis de la relación entre las variables mostró que el phubbing y sus dimensiones estaban positivamente asociados con constructos relacionados, incluyendo la adicción a internet, adicción al teléfono y FoMO. Conclusiones: Los hallazgos proporcionan evidencia empírica sobre la fiabilidad y validez de la versión en español de la Escala General de Phubbing como una herramienta para evaluar compor-tamientos de phubbing.

Abstract Introduction: The increased use of information and communication technologies, the internet and social networking sites has resulted in significant changes in the way people communicate, leading to negative consequences that might compromise psychological and physical health. The aim of this study was to present an adaptation and validation of the Generic Scale of Phubbing into a Spanish language context. Method: Three hundred forty-six Spanish respondents participated in the study by completing self-report measures for assessing their levels of phubbing, internet addiction, phone addiction, and fear of missing out (FoMO). Results: The scale adaptation to Spanish resulted in high quality psycho-metric properties and the original number of items and structure were preserved (nomophobia, interpersonal contact, self-isolation, and problem acknowledgement). In addition, the analysis of the relationship between variables showed that phubbing and its dimensions were positively associated with related constructs including internet addiction, phone ad-diction, and FoMO. Conclusions: The findings provide empirical evidence regarding the reliability and validity of the Spanish version of the Generic Scale of Phubbing as a tool to assess phubbing behaviours.

Resumen Como Magister in Sacra Pagina, Tomás de Aquino, tenía un triple oficio, según la conocida fórmula de Pedro Cantor: legere, disputare et praedicare. El Tomás que disputa ha recibido suficiente atención durante todos estos años. Recientemente, hay un mayor interés en la lectura que Tomás hace de la Palabra (“Tomismo Bíblico”). Las collationes del Aquinate al Ave María, el Padre Nuestro, el Credo y el Decálogo son bien conocidas. Sin embargo, ha pasado casi inadvertido el Tomás predicador en sus “sermones académicos” (Fr. L.-J. Bataillon OP es la excepción más destacable). En este artículo nos proponemos ahondar en este legado homilético tan auténtico del Doctor Angélico. Haremos un análisis del estilo y estructura de los sermones en general, para luego ahondar en su contenido doctrinal.

Abstract As Magister in Sacra Pagina, Thomas Aquinas, had a triple office, according to the well-known formula of Peter Cantor: legere, disputare et praedicare. The disputing Thomas has received sufficient attention during all these years. Recently, there is an increased interest in Thomas's reading of the Word ("Biblical Thomism"). Aquinas's collationes of the Hail Mary, the Lord's Prayer, the Creed, and the Decalogue are well known. However, the preaching Thomas in his "academic sermons" (Fr. L.-J. Bataillon OP is the most notable exception) has gone almost unnoticed. In this article we propose to delve into this authentic homiletic legacy of the Angelic Doctor. We will analyze the style and structure of the sermons in general, and then focus on their doctrinal content.

Resumen: Actualmente, existe un gran número de instituciones educativas antiguas que aún siguen en funcionamiento y han sido construidas sin tomar en cuenta criterios sismorresistentes. Estas edificaciones, por ser consideradas esenciales, deben mantener su operatividad durante y después de una solicitación sísmica. En esta investigación se analizaron dos módulos de dos niveles con plantas regulares pertenecientes a una institución educativa construida en el año 1994, los cuales se caracterizan por tener un sistema de pórticos de concreto armado en la dirección X y un sistema de albañilería confinada en la dirección Y. Estos módulos fueron analizados aplicando los parámetros lineales de la NTP E.030 y metodologías no lineales como el análisis dinámico no lineal (ADNL), donde las estructuras fueron sometidas a tres eventos sísmicos ocurridos en el Perú, las cuales fueron corregidas, escaladas y compatibilizadas con el espectro de respuesta por medio de los softwares Seismosignal y Seismomatch. Para el modelamiento se utilizó el software ETABS y, siguiendo las pautas del ASCE 41-17 y FEMA 356, se evaluó la respuesta de los registros sísmicos en las direcciones norte-sur y este-oeste, obteniéndose las derivas y gráficas de cortante y desplazamiento vs tiempo. En base a los resultados se obtuvo el desempeño sísmico para ambas direcciones, tomando en cuenta los niveles de desempeño dados por el HAZUS99, determinándose que en la dirección X presenta un desempeño de "Daños estructurales completos" y en Y de "Ligeros daños estructurales", concluyéndose que para este tipo de edificaciones es necesario un reforzamiento estructural en la dirección X para mejorar dicho desempeño.

Abstract: Currently, there are a large number of old educational institutions still in operation that were built without considering earthquake-resistant criteria. These buildings, being considered essential, must maintain their operability during and after a seismic event. In this research, two two-level modules with regular plans belonging to an educational institution built in 1994 were analyzed. These modules are characterized by having a reinforced concrete frame system in the X direction and a confined masonry system in the Y direction. These modules were analyzed by applying the linear parameters of NTP E.030 and nonlinear methodologies such as the Nonlinear Dynamic Analysis (NDA), where the structures were subjected to three seismic events that occurred in Peru, which were corrected, scaled, and matched to the response spectrum using Seismosignal and Seismomatch software. ETABS software was used for modeling, and following the guidelines of ASCE 41-17 and FEMA 356, the response of the seismic records in the north-south and east-west directions was evaluated, obtaining drifts and shear and displacement vs. time graphs. Based on the results, the seismic performance for both directions was obtained, considering the performance levels given by HAZUS99. It was determined that in the X direction, the performance is "Complete structural damage," and in the Y direction, it is "Slight structural damage," concluding that for this type of building, structural reinforcement in the X direction is necessary to improve performance.

RESUMEN Objetivo: Describir las características clínico-demográficas y los requerimientos ventilatorios en sujetos con esclerosis lateral amiotrófica (ELA) que ingresaron a un centro de desvinculación de ventilación mecánica y rehabilitación (CDVMR). Los objetivos secundarios fueron analizar el tiempo de sobrevida dentro del CDVMR y describir su condición al egreso. Materiales y métodos: Estudio observacional, transversal y retrospectivo. Se incluyeron sujetos mayores de 18 años que ingresaron entre el 1 de enero de 2016 y el 30 de marzo de 2023. Se describieron sus características clínico-demográficas y se realizó un análisis de sobrevida en función del tiempo. Resultados: Se incluyeron 33 sujetos. El 84,8 % de los sujetos presentaban traqueostomía y ventilación mecánica invasiva (VMI), mientras que 5 presentaban ventilación mecánica no invasiva (VMNI). Cuatro sujetos lograron una desvinculación parcial, y ninguno con VMNI requirió una vía aérea artificial. Doce sujetos (41,4 %) lograron fonación a fuga y 9 (27,3 %) recibieron alimentación terapéutica. La estadía fue de 174 días (57-319), y la mediana de tiempo de sobrevida fue de 254 días (IC 95 % 89-344). Conclusión: Los sujetos con ELA que ingresaron a los CDVMR fueron, en su mayoría, traqueostomizados, requirieron VMI y estaban postrados al ingreso. Además, tuvieron estadías prolongadas, con objetivos que generalmente no se centraron en la desvinculación de la ventilación mecánica. No obstante, fue posible trabajar otros aspectos que mejoran su vida diaria, como la fonación con ventilación a fuga y la alimentación oral recreativa.

ABSTRACT Objective: To describe the clinical-demographic characteristics and ventilatory requirements in subjects with amyotrophic lateral sclerosis (ALS) admitted to a weaning and rehabilitation center (WRC). The secondary objectives were to analyze survival time within the WRC and describe their condition at discharge. Materials and methods: An observational, cross-sectional, and retrospective study was conducted. Subjects over 18 years of age admitted between January 1, 2016, and March 30, 2023, were included. Clinical-demographic characteristics were described, and a time-based survival analysis was performed. Results: Thirty-three subjects were included. Of these, 84.8 % had a tracheostomy and invasive mechanical ventilation (IMV), while 5 had non-invasive mechanical ventilation (NIMV). Four subjects achieved partial weaning, and no subject with NIMV required an artificial airway. Twelve subjects (41.4 %) achieved leak speech, and 9 (27.3 %) received therapeutic feeding. The length of stay was 174 days (57-319), and the median survival time was 254 days (95 % CI 89-344). Conclusion: Subjects with ALS admitted to the CDVMR were mostly tracheostomized, required IMV, and were bedridden upon admission. Additionally, they had prolonged stays, with goals that generally did not focus on weaning from mechanical ventilation. However, it was possible to work on other aspects that improve their daily life, such as phonation with leak ventilation and recreational oral feeding.

ABSTRACT Background: Chronic myelogenous leukemia is a neoplastic proliferation of the granulocytic series. In Mexico, chronic myelogenous leukemia accounts for approximately 10% of all leukemias. Tyrosine-kinase inhibitors are considered front-line therapy in high-income countries, whereas allogeneic hematopoietic stem cell transplantation is a recognized therapeutic approach, mainly in low- and middle-income countries. Objective: To analyze the overall survival of persons with chronic myelogenous leukemia who have received tyrosine-kinase inhibitors or allogeneic hematopoietic stem cell transplantation in a medical center, since 1994, and briefly discuss the current indications of these treatments in the tyrosine-kinase inhibitors era. Methods: We retrospectively analyzed all patients with a diagnosis of chronic myelogenous leukemia treated in a medical center between 1994 and 2023; subsets of individuals who received an allogeneic hematopoietic stem cell transplantation or tyrosine-kinase inhibitors therapy as first-line treatment were analyzed. Results: 60 persons with chronic myelogenous leukemia were treated with allogeneic hematopoietic stem cell transplantation or tyrosine-kinase inhibitors: 35 received an allogeneic hematopoietic stem cell transplantation, whereas 25 were given tyrosine-kinase inhibitors. All patients who underwent an allogeneic hematopoietic stem cell transplantation engrafted successfully, and the procedure was completed on an outpatient basis in most cases (29/35). The median survival in allogeneic hematopoietic stem cell transplantation was 78.3 months (CI 95%: 0-205.6) and in persons given tyrosine-kinase inhibitors the median was not reached. Conclusion: Tyrosine-kinase inhibitors were significantly superior to allogeneic hematopoietic stem cell transplantation in prolonging the overall survival of persons with chronic myelogenous leukemia in our single institution experience. (Rev Invest Clin. 2024;76(2):91-6)

ABSTRACT Hydroponics is the technology of soil-less agriculture, in which plants are grown in an aquatic environment. While aquaponics is a fast-growing food production system that integrates hydroponics with aquaculture (fish farming). The objective of this study was to compare the production of chard (Beta vulgaris var. cicla L.) using a typical hydroponic system and an aquaponic system for tilapia (Oreochromis niloticus) production in a greenhouse. Six independent recirculation systems were used to test production by triplicate. Simple linear regression analysis showed that leaf production rate differed significantly between systems (p < 0.05), where the hydroponic trial produced 3.46 leaves week-1 and the aquaponic trial 1.53 leaves week-1. Plant biomass increased by 53.91 g week-1 in the hydroponic and 38.24 g week-1 in the aquaponic treatment, although these production rates did not differ significantly (p > 0.05). No significant differences were detected in the concentrations of ammonium (NH4 +), nitrite (NO2 -), and phosphate (PO4 +) between the treatments; however, significant differences were found for nitrate (NO3 -) between the systems (p < 0.05). Chard production in the hydroponic system was higher than in the aquaponic system in terms of leaf number and biomass.

RESUMEN La hidroponía es la tecnología de la agricultura sin suelo, en la que las plantas crecen en un medio acuático. Mientras que la acuaponía es un sistema de producción de alimentos en rápido crecimiento que integra la hidroponía con la acuicultura (cultivo de peces). El objetivo de este estudio fue comparar la producción de acelga (Beta vulgaris var. Cicla L.) mediante un sistema hidropónico típico y un sistema acuapónico de producción de tilapia (Oreochromis niloticus) en invernadero. Se utilizaron seis sistemas de recirculación independientes para comprobar la producción por triplicado. Un análisis de regresión lineal simple indicó que la tasa de producción de hojas difirió de forma significativa entre sistemas (p < 0.05), ya que en el hidropónico se obtuvieron 3.46 hojas semana-1, mientras que en el acuapónico fue de 1.53 hojas semana-1. La biomasa vegetal aumentó 53.91 g semana-1 en el tratamiento hidropónico y 38.24 g semana-1 en el acuapónico, aunque dichas tasas de producción no difirieron significativamente (p>0.05). No se detectaron diferencias significativas en las concentraciones de amonio (NH4 +), nitrito (NO2 -), y fosfato (PO4 +) en ambos tratamientos; pero se encontraron diferencias significativas para nitratos (NO3 -) entre sistemas (p < 0.05). La producción de acelgas en el sistema hidropónico fue mayor que en el sistema acuapónico en cuanto al número de hojas y la biomasa.

Abstract Objective: To determine the effectiveness of tele rehabilitation versus supervised treatment in the functional recovery of patients with distal radius fracture. Method: A randomized clinical trial was conducted that included 91 patients with distal radius fractures grades AO23 A and AO23B, which were randomly assigned to a treatment group, the supervised rehabilitation group received for two weeks a program of 10 treatment sessions and the tele rehabilitation group received through the Moodle platform instructions to carry out the rehabilitation program. Outcome measures (functionality, active range of motion, hand grip strength, quality of life and pain) were measured at the time of admission to rehabilitation and at 1, 3 and 6 months. Results: In both treatment groups at 6 months, statistically significant intragroup differences in functionality were demonstrated, with no intergroup differences. Conclusions: At 6 months, both rehabilitation programs increase functionality, range of motion, quality of life and decrease pain, without statistically significant differences intergroup.

Resumen Objetivo: Determinar la efectividad de la telerrehabilitación en comparación con el tratamiento supervisado en la recuperación funcional de los pacientes con fractura de radio distal. Método: Se realizó un ensayo clínico aleatorizado que incluyó 91 pacientes con fracturas de radio distal de grados AO23A y AO23B, los cuales se asignaron aleatoriamente a un grupo de rehabilitación supervisado que recibió durante 2 semanas un programa de 10 sesiones de tratamiento o un grupo de telerrehabilitación que mediante la plataforma de Moodle recibió instrucciones para realizar el programa de rehabilitación. Las medidas de resultado (funcionalidad, rango de movimiento activo, fuerza de prensión de la mano, calidad de vida y dolor) se midieron en el momento del ingreso a rehabilitación y a los 1, 3 y 6 meses. Resultados: A los 6 meses, ambos grupos de tratamiento demostraron diferencias estadísticamente significativas intragrupo en la funcionalidad, sin diferencias intergrupo. Conclusiones: A los 6 meses, ambos programas de rehabilitación aumentan la funcionalidad, el rango de movimiento y la calidad de vida, y disminuyen el dolor, sin diferencias estadísticamente significativas intergrupo.

Abstract 23. The study of fish diets allows us to understand how they influence other organisms in the ecosystem through trophic interactions. The aim of this study was to expand our knowledge of the trophic habits of Acestrorhynchus pantaneiro in the alluvial valley of the Paraná River, Corrientes (Argentina). This study involved the collection and evaluation of 140 individuals of A. pantaneiro between May 2016 and February 2018 in four areas of the Paraná River, downstream of the Yacyretá dam. The stomach contents were analyzed at the taxonomic level to calculate the following indicators: frequency of occurrence index, volumetric method, and dietary index. Of the 140 specimens evaluated, 58% had some type of food item in their stomach, whereas 42% were found empty. The analysis of stomach contents allowed us to differentiate several species consumed belonging to the orders Perciformes, Characiformes and Siluriformes; however, the genus Crenicichla presented the highest percentage values of the indicators. The results of this study suggest that A. pantaneiro, in addition to having piscivorous trophic habits, demonstrated preferences for consuming species of the genus Crenicichla.

Resumen 19. El estudio de la dieta de los peces permite entender cómo éstos influyen en los demás organismos del ecosistema a través de las interacciones tróficas. El objetivo del estudio fue ampliar el conocimiento que se tiene del hábito trófico de Acestrorhynchus pantaneiro en el valle aluvial del río Paraná. Se evaluaron contenidos estomacales de 140 individuos de A. pantaneiro recolectados con pesca eléctrica en cuatro zonas del río Paraná, aguas abajo de la represa de Yacyretá, entre mayo de 2016 y febrero de 2018. Se evaluó la presencia/ausencia de contenido estomacal y para cada ítem se analizó a nivel taxonómico procediendo al cálculo de los siguientes indicadores: índice de frecuencia de ocurrencia, método volumétrico e índice alimentario. El 58% de las muestras presentaron algún tipo de ítem alimentario en el contenido estomacal, mientras que el 42% se encontraron vacíos. Los ítems más frecuentes hallados en los estómagos fueron especies de los órdenes Perciformes, Characiformes y Siluriformes, estimándose los mayores valores porcentuales para el género Crenicichla. Los resultados de este estudio sugieren que A. pantaneiro, además de tener hábitos tróficos piscívoros, demostró preferencias por el consumo de especies del género Crenicichla.

ABSTRACT BACKGROUND: Neck circumference (NC) is a useful anthropometric measure for predicting obstructive sleep apnea (OSA). Ethnicity and sex also influence obesity phenotypes. NC cut-offs for defining OSA have not been established for the Latin American population. OBJECTIVES: To evaluate NC, waist circumference (WC), and body mass index (BMI) as predictors of OSA in the Colombian population and to determine optimal cut-off points. DESIGN AND SETTING: Diagnostic tests were conducted at the Javeriana University, Bogota. METHODS: Adults from three cities in Colombia were included. NC, WC, and BMI were measured, and a polysomnogram provided the reference standard. The discrimination capacity and best cut-off points for diagnosing OSA were calculated. RESULTS: 964 patients were included (57.7% men; median age, 58 years) and 43.4% had OSA. The discrimination capacity of NC was similar for men and women (area under curve, AUC 0.63 versus 0.66, P = 0.39) but better for women under 60 years old (AUC 0.69 versus 0.57, P < 0.05). WC had better discrimination capacity for women (AUC 0.69 versus 0.57, P < 0.001). There were no significant differences in BMI. Optimal NC cut-off points were 36.5 cm for women (sensitivity [S]: 71.7%, specificity [E]: 55.3%) and 41 cm for men (S: 56%, E: 62%); and for WC, 97 cm for women (S: 65%, E: 69%) and 99 cm for men (S: 53%, E: 58%). CONCLUSIONS: NC and WC have moderate discrimination capacities for diagnosing OSA. The cut-off values suggest differences between Latin- and North American as well as Asian populations. BACKGROUND (NC . (OSA) phenotypes cutoffs cut offs OBJECTIVES , (WC) (BMI cutoff off SETTING University Bogota METHODS measured standard calculated RESULTS 96 57.7% 577 57 7 (57.7 age 5 434 43 4 43.4 area curve 063 0 63 0.6 066 66 0.66 0.39 039 39 6 069 69 057 0.57 0.05. 005 0.05 05 0.05) 0.001. 0001 0.001 001 0.001) 365 36 36. sensitivity S [S] 717 71 71.7% E [E] 55.3% 553 55 3 (S 56 56% 62% 62 62%) 9 65 65% 69% 53 53% 58%. 58% 58%) CONCLUSIONS populations (OSA (WC 57.7 (57. 43. 06 0. 0.3 03 0.5 00 0.0 000 0.00 [S 71.7 [E 55.3 57. (57 71. 55. (5 (

Herein, we report the synthesis and evaluation of four aminoguanidine hydrazone derivatives with different aromatic moieties. This class of compounds presents a series of biological applications. Derivative AGH-3 with an indole nucleus offered the highest antioxidant capacity with results comparable to Trolox in 2,2-diphenyl-2-picrylhydrazyl radical (DPPH•), 2,2-azinobis(3 ethylbenzothiazoline-6-sulfonic acid (ABTS•+), FeIII reduction assay (FRAP), and nitric oxide (•NO) radical scavenging assays. Furthermore, AGH-3 showed the highest antiproliferative activity against human kidney cancer cells (786-0) with concentration necessary to inhibit 50% cell growth (GI50) = 6.3 μM; additionally, in biophysical studies, AGH-3 interacted with ctDNA (biological target model) forming a fluorescent supramolecular complex with a binding constant (Kb) of 2.89 × 103 M-1 with preferentially an intercalator mechanism. The tested compounds revealed the potential of aminoguanidine hydrazones as a strategic class of compounds with multitarget biological activity. Herein moieties applications AGH3 AGH 3 AGH- 2,2diphenyl2picrylhydrazyl 22diphenyl2picrylhydrazyl diphenylpicrylhydrazyl 2,2 diphenyl 2 picrylhydrazyl DPPH•, DPPH DPPH• , (DPPH•) 2,2azinobis3 22azinobis3 azinobis 2,2-azinobis( ethylbenzothiazoline6sulfonic ethylbenzothiazolinesulfonic ethylbenzothiazoline 6 sulfonic ABTS•+, ABTS ABTS•+ (ABTS•+) FRAP, FRAP (FRAP) •NO NO (•NO assays Furthermore 7860 786 0 (786-0 50 GI50 GI (GI50 63 6. μM additionally studies model Kb (Kb 289 89 2.8 10 M1 M 1 M- mechanism 2diphenyl2picrylhydrazyl 22 2, (DPPH• 2azinobis3 2,2azinobis 22azinobis 2,2-azinobis ABTS• (ABTS•+ (FRAP 78 (786- 5 GI5 (GI5 28 8 2. (DPPH 2azinobis (ABTS• 7 (786 (GI (ABTS (78 (7 (

Lipases have been used in industrial processes as biocatalysts for transesterification reactions. The synergism between enzymes and magnetic properties may be reached by using magnetic nanoparticles (MNPs) as support to immobilize them in aggregate structures, denominated by magnetic crosslinked enzyme aggregates (MCLEA). One of the advantages of such supports is the possibility of using magnetic separation for enzyme recovery, reducing costs and allowing reuse in continuous systems. Here, porcine pancreatic lipase (PPL) was immobilized onto functionalized magnetite support (Fe3O4-APTS) with a protein binding efficiency of 78.84%. Physical and chemical properties of the nanoparticles and immobilized lipase were characterized by X-ray diffraction (XDR), transmission electron microscopy (TEM), infrared spectroscopy (FTIR), dynamic light scattering (DLS), zeta potential, vibrating sample magnetometer measurements (VSM), and 57Fe Mössbauer spectroscopy. The immobilized lipase additionally exhibited improved stability across wide pH and temperature ranges compared with free lipase. The immobilized derivate also attained good reusability, maintaining 61.37% of its initial activity after 6 reaction cycles. Through magnetic behavior and also because of its surface modification to crosslinking the enzyme, the MCLEA produced in this work has enhanced the biocatalytic activities of PPL. reactions MNPs (MNPs structures MCLEA. . (MCLEA) recovery systems Here PPL (PPL Fe3O4APTS FeOAPTS Fe3O4 APTS Fe O (Fe3O4-APTS 7884 78 84 78.84% Xray X ray XDR, XDR , (XDR) TEM, TEM (TEM) FTIR, FTIR (FTIR) DLS, DLS (DLS) potential VSM, VSM (VSM) reusability 6137 61 37 61.37 cycles (MCLEA FeO Fe3O 788 7 8 78.84 (XDR (TEM (FTIR (DLS (VSM 613 3 61.3 78.8 61. 78.

Abstract Breast cancer (BC) is the most common malignant neoplasia in women and is responsible for one in six deaths from cancer in the female population. Five years after diagnosis, BC survival rates currently exceed 80%. Cardiovascular disease (CVD) is a frequent cause of morbidity and mortality in BC, mainly in patients receiving cardiotoxic drugs (anthracyclines, immunotherapy) and radiotherapy (RT). CVD and BC have common risk factors (RF), which are related to aging, traditional and cardiometabolic RFs (obesity, dyslipidemia, consumption of alcoholic beverages), and others associated with sex and reproductive women's age, such as early menarche, late menopause, nulliparity, use of oral contraceptives, as well as hormone replacement therapy in postmenopause. Risk stratification and the promotion of an ideal state of cardiovascular (CV) health are fundamental in preventing CVD in survivors. Therapeutic management and follow-up of patients with BC require a multidisciplinary team to reduce complications and mortality of CV origin. (BC population diagnosis 80 80% (CVD anthracyclines, anthracyclines (anthracyclines immunotherapy RT. RT . (RT) RF, RF , (RF) aging obesity, obesity (obesity dyslipidemia beverages, beverages beverages) womens s age menarche menopause nulliparity contraceptives postmenopause (CV survivors followup follow up origin 8 (RT (RF

ABSTRACT Introduction: Type 2 diabetes mellitus is characterized by hyperglycemia due to insufficient insulin production by β cells. Myeloperoxidase promotes oxidative stress during inflammation and ceruloplasmin is considered its endogenous inhibitor. Objective: To evaluate the relationship between ceruloplasmin and myeloperoxidase, determined simultaneously in the serum of type 2 diabetic patients. Methods: A total of 362 type 2 diabetic patients and 110 healthy subjects were studied. Serum ceruloplasmin activity was determined by the Siotto KM method and myeloperoxidase by the Kraeisz JE method. Results: 72% of diabetic patients had hyperglycemia and 77% had abdominal obesity. The activities of both enzymes were significantly increased relative to the control group. The correlation coefficient of enzyme activity was low. The ORMO/CP ratio of diabetic patients exceeded that of controls. Ceruloplasmin did not inhibit myeloperoxidase. Conclusions: Myeloperoxidase predominated, therefore, the inhibitory effect of ceruloplasmin was not manifested. The high activity of myeloperoxidase was associated with a worsening of the clinical picture of the diabetic patient.

RESUMEN Introducción: La diabetes mellitus tipo 2 se caracteriza por la hiperglucemia debido a la insuficiente producción de insulina de las células β. La mieloperoxidasa promueve el estrés oxidativo durante la inflamación y la ceruloplasmina se considera su inhibidor endógeno. Objetivo: Evaluar la relación entre la ceruloplasmina y la mieloperoxidasa, determinadas simultáneamente en el suero de pacientes diabéticos tipo 2. Métodos: Se estudiaron 362 pacientes diabéticos tipo 2 y 110 sujetos sanos. La actividad sérica de la ceruloplasmina se determinó por el método de Siotto; y el de la mieloperoxidasa, por el de Kraeisz. Resultados: El 72 % de los pacientes diabéticos tenían hiperglucemia y el 77 % presentaba obesidad abdominal. Las actividades de ambas enzimas se incrementaron significativamente en relación con el grupo control. El coeficiente de correlación de la actividad enzimática resultó bajo. El cociente RMPO/CP de los pacientes diabéticos superó el de los controles. La ceruloplasmina no inhibió la mieloperoxidasa. Conclusiones: Predominó la mieloperoxidasa, por tanto, no se manifestó el efecto inhibitorio de la ceruloplasmina. La elevada actividad de la mieloperoxidasa se asocia con un agravamiento del cuadro clínico del paciente diabético.