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Resumen: El objetivo de este trabajo fue evaluar los factores explicativos de la respuesta inmune humoral en adultos mayores de establecimientos de estancia prolongada de Buenos Aires, Argentina, hasta 180 días post vacunación. Se utilizó un diseño de cohorte abierta, prospectiva, multicéntrica, con voluntarios que recibieron dos dosis de vacunas Sputnik V, Sinopharm o AZD1222. Se analizaron muestras de plasma en los tiempos 0, 21 días post primera dosis, 21 días post segunda dosis, 120 y 180 días post primera dosis. Se ajustaron modelos lineales marginales y aditivos generalizados mixtos para evaluar el comportamiento de la concentración de anticuerpos IgG anti-Spike en el tiempo según grupo de exposición (naïve/no-naïve) y vacuna. Las covariables analizadas fueron: ocurrencia de brote de COVID-19 en establecimientos de estancia prolongada y comorbilidades. Se incluyeron en el análisis 773 participantes con una mediana de edad de 83 años (RIQ: 76-89). Al final del estudio, los niveles de anticuerpos del grupo naïve: Sinopharm fueron significativamente menores que el resto de los grupos (p < 0,05); los del no-naïve: Sinopharm resultaron similares a los naïve que recibieron AZD1222 (p = 0,945) o Sputnik V (p = 1). Los participantes expuestos a brotes en establecimientos de estancia prolongada presentaron niveles de anticuerpos significativamente mayores, independientemente del grupo de exposición y la vacuna (p < 0,001). Concluimos que la exposición previa a COVID-19, el tipo de vacuna y la pertenencia a un establecimiento de estancia prolongada con antecedente de brote son factores a considerar frente a futuros eventos epidémicos con dinámicas de transmisión y mecanismos inmunológicos similares al COVID-19, en poblaciones similares a la analizada en este trabajo.

Resumo: Este estudo teve como objetivo avaliar os fatores explicativos da resposta imune humoral em idosos em instituições de longa permanência em Buenos Aires, Argentina, até 180 dias após a vacinação. Foi realizado um estudo de coorte aberto, prospectivo e multicêntrico, com voluntários que receberam duas doses das vacinas Sputnik V, Sinopharm ou AZD1222. As amostras de plasma foram analisadas nos tempos 0, 21 dias após a primeira dose, 21 dias após a segunda dose, 120 e 180 dias após a primeira dose. Os modelos lineares marginais e os aditivos generalizados mistos foram ajustados para determinar o comportamento da concentração de anticorpos IgG anti-Spike ao longo do tempo de acordo com o grupo de exposição (naïve/no-naïve) e vacina. As covariáveis analisadas foram ocorrência de pico de COVID-19 nas instituições de longa permanência e comorbidades. Foram incluídos 773 participantes, com média de idade de 83 anos (IIQ: 76-89). Os resultados apontaram níveis de anticorpos do grupo naïve: Sinopharm significativamente mais baixos do que os outros grupos (p < 0,05); e as variáveis do grupo no-naïve: Sinopharm foram semelhantes à do grupo naïve que recebeu AZD1222 (p = 0,945) ou Sputnik V (p = 1). Os participantes expostos a picos nas instituições de longa permanência apresentaram níveis de anticorpos significativamente maiores, independentemente do grupo de exposição e da vacina (p < 0,001). Conclui-se que a exposição prévia à COVID-19, tipo de vacina e adesão a uma instituição de longa permanência com histórico de pico são fatores a serem considerados em futuros eventos epidêmicos com dinâmica de transmissão e mecanismos imunológicos semelhantes à COVID-19, em populações semelhantes à analisada neste trabalho.

Abstract: This study evaluated the explanatory factors of humoral immune response in older adults admitted to long-term care institutions in Buenos Aires, Argentina, up to 180 days after vaccination. An open-label, prospective, multicenter cohort study was conducted with volunteers who received two doses of the Sputnik V, Sinopharm, or AZD1222 vaccines. Plasma samples were analyzed at 0 and 21 days after the first dose, 21 days after the second dose, and 120 and 180 days after the first dose. Marginal linear models and generalized additives mixed models were adjusted to determine the behavior of anti-spike IgG antibody concentration over time according to exposure group (naïve/no-naïve) and vaccine. Occurrence of an outbreak of COVID-19 in long-term care institutions and comorbidities were the covariates analyzed. A total of 773 participants were included, with a mean age of 83 years (IQR: 76-89). Results showed that antibody levels in the naïve: Sinopharm group were significantly lower to the other groups (p < 0.05). Antibody levels in the no-naïve: Sinopharm group were similar to those in the naïve group who received AZD1222 (p = 0.945) or Sputnik V (p = 1). Participants exposed to outbreaks in long-term care institutions had significantly higher antibody levels, regardless of exposure group and vaccine (p < 0.001). In conclusion, previous exposure to COVID-19, type of vaccine, and admittance into a long-term care institution with a history of outbreaks are factors to be considered in future epidemic events with transmission dynamics and immunological mechanisms similar to COVID-19, in populations similar to the one analyzed.

https://doi.org/10.1590/0102-311xes155023

Chemical thinning programs for vigorous ‘Maxi Gala’ apple trees under black anti-hail netting in Southern Brazil Maxi Gala antihail anti hail
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Marchioretto, Lucas De Ross

; Rossi, Andrea De

; Marodin, Gilmar Arduino Bettio

Revista Ceres

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2024, Volume 71 elocation e71005

Abstract: En | Text: En | PDF: En

ABSTRACT Hail netting increases natural fruitlet drop. Mixing lower concentrations of Plant Growth Regulators (PGRs) and spraying on more advanced fruitlets could promote adequate crop load management and improve fruit quality. The objective of this study was to evaluate thinning programs with low concentrations of PGRs sprayed at advanced fruitlet size looking for reducing crop load, enhancing fruit quality, and preserving yield. On 2020/21 and 2021/22, in an orchard covered with hail netting in Bom Jesus-RS, eight programs were tested on vigorous ‘Maxi Gala’: Benzyladenine (BA)+Gibberellic acid4+7 (BA-GA) at full bloom (FB) and BA+Ethephon (ETH) at 15mm; BA-GA at FB and Naphthalene acetic acid+Carbaryl (CB) at 7 mm; BA-GA at FB and BA+CB at 15 mm; ETH+CB at 15 mm and Metamitron (MM)+ETH at 20 mm; BA-GA at FB and BA at 7 mm and MM at 20 mm; MM at 7 mm and MM at 20 mm; Manual Thinning Only; Untreated Control. The treatments containing CB reduced fruit set, although diminished yield unsustainably. All PGR programs improved fruit quality. In conclusion, BA-GA at FB and BA+ETH at 15 mm, and MM at 7 mm and MM at 20 mm reduce crop load, preserve yield and improve fruit quality. drop (PGRs quality 202021 2020 21 2020/2 202122 2021 22 2021/22 JesusRS, JesusRS Jesus RS, RS Jesus-RS Maxi Gala Gala’ BA+Gibberellic BAGibberellic +Gibberellic Gibberellic acid47 acid acid4 acid4+ BAGA GA (BA-GA (FB BAEthephon Ethephon ETH (ETH 15mm acidCarbaryl Carbaryl (CB BACB 1 ETHCB MM+ETH MMETH +ETH 2 Only Control set unsustainably conclusion BAETH 20202 202 2020/ 20212 2021/2 2021/

https://doi.org/10.1590/0034-737x202471000005

Efecto de la exposición previa a COVID-19, ocurrencia de brotes y tipo de vacuna en la respuesta inmune humoral de adultos mayores institucionalizados COVID19, COVID19 COVID 19, 19 COVID-19 COVID1 1 COVID-1 COVID-
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Aguirre, Fernanda

; Marro, María Jimena

; Rodriguez, Pamela E.

; Rall, Pablo

; Miglietta, Esteban A.

; Miranda, Lucía A. López

; Poncet, Verónica

; Pascuale, Carla A.

; Ballejo, Christian A.

; Ricardo, Tamara

; Miragaya, Yanina

; Gamarnik, Andrea

; Rossi, Andrés H.

; Silva, Andrea P.

Cadernos de Saúde Pública

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2024, Volume 40 N. 9 elocation e00155023

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

https://doi.org/10.1590/0102-311xes155023

Presentación clínica de patologías no malignas que (y simulan leucemia cutis: a propósito de dos casos
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Sotelo, Catrian

; Cervini, Andrea B.

; Cella, Eliana

; Galluzzo, María L

; Rossi, Jorge

; Rubio, Patricia

; Felice, María S.

Archivos argentinos de pediatría

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nov 2023, Volume 121 N. 5 Pages 16 - 16

Abstract: Es | Text: Es | PDF: Es

RESUMEN La infiltración cutánea por células leucémicas conocida como leucemia cutis es una presentación infrecuente de esta patología y constituye un desafío diagnóstico. Los diagnósticos como infecciones, otras patologías neoplásicas con afectación cutánea y los trastornos histiocíticos, entre otros, constituyen los principales diagnósticos diferenciales, ya que configuran un escenario pronóstico y terapéutico diferente. Se presentan dos pacientes que fueron diagnosticados inicialmente como leucemia cutis, cuyo diagnóstico final fue de patologías no malignas.

https://doi.org/10.5546/aap.2022-02796

Effect of Combined Training on Body Image, Body Composition and Functional Capacity in Patients with Breast Cancer: Controlled Clinical Trial Image Cancer
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Reis, Andréa Dias

; Pereira, Paula Tâmara Vieira Teixeira

; Castro Filha, Jurema Gonçalves Lopes

; Rodrigues, Evelyn Feitosa

; Laranjeira, Isadora Pinheiro

; Ramallo, Bianca Trovello

; Castro, Marcela Rodrigues de

; Rossi, Fabrício Eduardo

; Freitas Júnior, Ismael Forte

; Garcia, João Batista Santos

Revista Brasileira de Ginecologia e Obstetrícia

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may 2023, Volume 45 N. 5 Pages 242 - 252

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Objetivo Avaliar o efeito do treinamento combinado na imagem corporal (IB), composição corporal e capacidade funcional em pacientes com câncer de mama. Assim como a relação do IB com a composição corporal e capacidade funcional. Métodos Este foi um estudo de Ensaio Clínico Controlado, este estudo incluiu 26 pacientes com câncer de mama (30 a 59 anos). O grupo de treinamento (n = 13) foi submetido a 12 semanas de treinamento, incluindo três sessões de 60 min de exercício aeróbio e treinamento de resistência, e duas sessões de treinamento de flexibilidade por semana; cada exercício de flexibilidade durou 20s. O Grupo Controle (n = 13) recebeu apenas o tratamento hospitalar padrão. Os participantes foram avaliados no início e após 12 semanas. O IB (desfechos primários) foi avaliado por meio do Body Image After Breast Cancer Questionnaire; A composição corporal foi estimada com os indicadores: índice de massa corporal; Peso, relação cintura-quadril; Relação da altura da cintura; Índice de conicidade; Índice ponderal recíproco; Porcentagem de gordura; Circunferência do abdômen e cintura; Capacidade funcional por aptidão cardiorrespiratória (cicloergômetro) e força (dinamômetro manual). A estatística foi realizada na Bioestatística e no Stata 14.0 (α = 5%). Resultados Os pacientes do grupo de treinamento apresentaram redução da dimensão da limitação (p = 0,036) no IB, porém, foi observado aumento da circunferência da cintura em ambos os grupos. Além disso, um aumento do VO2máx (p <0,001) e da força nos braços direito (p = 0,005) e esquerdo (p = 0,033). Conclusão O treinamento combinado demonstra ser uma estratégia eficaz e não farmacológica para pacientes com câncer de mama, com melhora do IB e da capacidade funcional, alterando variáveis relacionadas negativamente quando não há treinamento físico. , (IB) Controlado 2 30 (3 5 anos. anos . anos) n 13 1 6 resistência semana 20s s padrão desfechos primários Questionnaire indicadores Peso cinturaquadril quadril cintura-quadril conicidade recíproco gordura cicloergômetro (cicloergômetro dinamômetro manual. manual manual) 140 14 0 14. α 5%. 5% 5%) p 0,036 0036 036 porém grupos disso VOmáx VO máx <0,001 0001 001 0,005 0005 005 0,033. 0033 0,033 033 0,033) físico (IB 3 ( 0,03 003 03 <0,00 000 00 0,00 0,0 <0,0 0, <0, <0 <

Abstract Objective Evaluate the effect of combined training on body image (BI), body composition and functional capacity in patients with breast cancer. As also the relationship of BI with body composition and functional capacity. Methods This was a Controlled Clinical Trial study, this study including 26 patients with breast cancer (30 to 59 years). The training group (n = 13) underwent 12 weeks of training, including three 60-min sessions of aerobic exercise and resistance training, and two sessions of flexibility training per week; each flexibility exercise lasted 20s. The Control Group (n = 13) received only the standard hospital treatment. Participants were evaluated at baseline and after 12 weeks. BI (primary outcomes) was assessed using the Body Image After Breast Cancer Questionnaire; Body composition was estimated with the indicators: Body mass index; Weight, Waist hip Ratio; Waist height ratio; Conicity index; Reciprocal ponderal index; Percentage of fat; Circumference of the abdomen and waist; Functional capacity by cardiorespiratory fitness (cycle ergometer) and strength (manual dynamometer). The statistic was performed in the Biostatistics and Stata 14.0 (α = 5%). Results The patients in the training group showed a reduction in the limitation dimension (p = 0.036) on BI, However, an increase in waist circumference was observed in both groups. In addition an increase in VO2max (p < 0.001) and strength in the right (p = 0.005) and left arms (p = 0.033). Conclusion Combined training demonstrates to be an effective and non-pharmacological strategy to patients with breast cancer, with improvement on BI and functional capacity, changing related variables negatively when there is no physical training. , (BI) 2 30 (3 5 years. years . years) n 13 1 60min min 60 week 20s s treatment primary outcomes Questionnaire indicators index Weight Ratio ratio fat cycle ergometer manual dynamometer. dynamometer dynamometer) 140 14 0 14. α 5%. 5% 5%) p 0.036 0036 036 However groups VOmax VO max 0.001 0001 001 0.005 0005 005 0.033. 0033 0.033 033 0.033) nonpharmacological non pharmacological (BI 3 ( 6 0.03 003 03 0.00 000 00 0.0 0.

https://doi.org/10.1055/s-0043-1770126

Chemical thinning programs for 'Fuji Mishima' apple trees under black anti-hail net Fuji Mishima antihail anti hail
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Marchioretto, Lucas De Ross

; Rossi, Andrea De

; Marodin, Gilmar Arduino Bettio

Pesquisa Agropecuária Brasileira

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2023, Volume 58 elocation e03196

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo O objetivo deste trabalho foi avaliar programas de raleio químico contendo misturas de diferentes reguladores de crescimento de plantas, em baixas concentrações, aplicados em macieiras 'Fuji Mishima' pós-floração, bem como identificar os mais eficazes em reduzir a frutificação efetiva, diminuir a necessidade de raleio manual e melhorar a qualidade dos frutos. Sob tela antigranizo preta, as macieiras foram pulverizadas com os seis seguintes protocolos de raleio químico (tratamentos): benziladenina (BA) + giberelina4+7 (GA) em plena floração (PF) e BA + carbaril (CB) em frutos com 15 mm de diâmetro; BA + GA em PF e ácido naftalenoacético (ANA) + CB em frutos com 7 mm de diâmetro; BA + GA em PF e BA + CB em frutos com 15 mm de diâmetro; ethephon (ETH) + CB em frutos com 15 mm de diâmetro e metamitron (MM) + ETH em frutos com 20 mm de diâmetro; e MM em frutos com 7 mm de diâmetro e MM em frutos com 20 mm de diâmetro. Os tratamentos foram comparados com um controle não tratado e um de raleio manual. A tela preta reduziu a radiação fotossinteticamente ativa em 22%. Para maçãs 'Fuji Mishima' sob tela preta antigranizo, o programa de raleio químico BA + GA (47 + 47 g i.a. ha-1) em PF, seguido de BA + CA (80 + 288 g i.a. ha-1) em frutos com 15 mm de diâmetro, reduz consistentemente a frutificação efetiva, requer menos raleio manual e melhora a massa e o tamanho dos frutos. plantas concentrações Fuji Mishima pósfloração, pósfloração pós floração, pós-floração efetiva (tratamentos) (BA giberelina47 giberelina giberelina4 giberelina4+ (GA (PF (CB 1 ANA (ANA (ETH (MM 2 22 22% (4 4 ia i i.a ha1 ha ha-1 80 (8 28 (tratamentos ( ha- 8

Abstract The objective of this work was to evaluate chemical thinning programs containing mixtures of different plant growth regulators, at low concentrations, applied to 'Fuji Mishima' apple trees at post-blossom, as well as to identify the most effective in reducing fruit set, decreasing the need of manual thinning, and improving fruit quality. Under a black anti-hail net, the apple trees were sprayed with the six following chemical thinning protocols (treatments): benzyladenine (BA) + gibberellin4+7 (GA) at full bloom (FB) and BA + carbaryl (CB) on fruitlets with a 15 mm diameter; BA + GA at FB and naphthaleneacetic acid (NAA) + CB on fruitlets with a 7 mm diameter; BA + GA at FB and BA + CB on fruitlets with a 15 mm diameter; ethephon (ETH) + CB on fruitlets with a 15 mm diameter and metamitron (MM) + ETH on fruitlets with a 20 mm diameter; and MM on fruitlets with a 7 mm diameter and MM on fruitlets with a 20 mm diameter. The treatments were compared with an untreated and a manual thinning control. The black net reduced photosynthetically active radiation in 22%. For 'Fuji Mishima' apples under a black anti-hail net, the chemical thinning program consisting of BA + GA (47 + 47 g a.i. ha-1) at FB, followed by BA + CB (80 + 288 g a.i. ha-1) on fruitlets with a 15 mm diameter, consistently reduces fruit set, requires less manual thinning, and improves fruit weight and size. regulators concentrations Fuji Mishima postblossom, postblossom post blossom, blossom post-blossom set quality antihail anti hail (treatments) (BA gibberellin47 gibberellin gibberellin4 gibberellin4+ (GA (FB (CB 1 NAA (NAA (ETH (MM 2 control 22 22% (4 4 ai i a.i ha1 ha ha-1 80 (8 28 size (treatments ( ha- 8

https://doi.org/10.1590/s1678-3921.pab2023.v58.03196

Guest editorial: The UN sustainable development goals and management theory and practice
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Souza-Piao, Roberta

; Scalco, Andrea Rossi

; Vazquez-Brust, Diego

; Plaza-Ubeda, Jose Antonio

; Tavera-Cortés, María Elena

RAUSP Management Journal

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dec 2022, Volume 57 N. 4 Pages 358 - 361

Abstract: En | Text: En | PDF: En

https://doi.org/10.1108/rausp-09-2022-269

Justiça organizacional e doença cardiometabólica: uma revisão sistemática
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Scalabrin, Angela

; Silva, Andréa Tenório Correia da

; Menezes, Paulo Rossi

Ciência & Saúde Coletiva

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sep 2022, Volume 27 N. 9 Pages 3517 - 3530

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Os efeitos da justiça organizacional sobre a saúde dos trabalhadores têm sido investigados em diversas áreas de trabalho. Entretanto, a sistematização da informação disponível sobre os efeitos relacionados às doenças cardiovasculares (DCV) e à diabetes é escassa. O objetivo deste artigo é revisar sistematicamente a associação entre justiça organizacional e DCV e metabólica em trabalhadores adultos. A estratégia de busca incluiu os termos justiça organizacional, doença coronariana, doença cerebrovascular, hipertensão arterial sistêmica, diabetes mellitus e DCV. As bases de dados investigadas foram MEDLINE, EMBASE e LILACS. A qualidade dos estudos foi avaliada pelo instrumento desenvolvido pelo National Institute of Health. Foram identificados 1.959 títulos. Após avaliação, foram selecionados oito estudos. Os indivíduos com percepção de justiça organizacional alta apresentaram menor risco de DCV e metabólica. Baixa justiça organizacional tem repercussões para a saúde cardiovascular e metabólica dos trabalhadores. A elaboração de estratégias para promover justiça organizacional deve ser priorizada para assim mitigar seus impactos para os trabalhadores e as instituições.

Abstract The effects of organizational justice on workers’ health have been investigated in several areas of work. However, the systematization of available information on the effects related to cardiovascular diseases (CVD) and diabetes is scarce. This article aims to systematically review the association between organizational justice and CVD and metabolic disease in adult workers. The search strategy included the terms organizational justice, coronary heart disease, cerebrovascular disease, systemic arterial hypertension, diabetes mellitus and CVD. This study investigated the following databases: MEDLINE, EMBASE, and LILACS. The quality of the studies was assessed using the instrument developed by the National Institute of Health. Results: This study identified 1,959 titles. After evaluation, eight studies were selected. Individuals with a high perception of organizational justice showed a lower risk of CVD and metabolic disease, whereas low organizational justice presented repercussions for the cardiovascular and metabolic health of workers. The development of strategies to promote organizational justice must be prioritized and thus mitigate its impacts on workers and institutions.

https://doi.org/10.1590/1413-81232022279.23482021

Justiça organizacional e doença cardiometabólica: uma revisão sistemática
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Scalabrin, Angela

; Silva, Andréa Tenório Correia da

; Menezes, Paulo Rossi

Ciência & Saúde Coletiva

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sep 2022, Volume 27 N. 9 Pages 3517 - 3530

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.1590/1413-81232022279.23482021

10.

Reseña / Herramientas participativas para la comunicación comunitaria. Una metodología de intervención en situación
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Rossi, Andrea

Revista de extensión universitaria

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jun 2022, N. 16 Pages 12 - 12

Abstract: Pt Es En | Text: Pt Es En | PDF: Pt | PDF: Es | PDF: En

Resumo Esta é uma publicação realizada pela Área de Comunicação Comunitária da Faculdade de Ciências da Educação da Universidade Nacional de Entre Ríos que resume a história de 16 anos de trabalho no território. Por meio da sistematização de experiências, o livro se propõe socializar ferramentas e recursos utilizados em processos de intervenção social, implementados em diferentes contextos, na perspectiva teórica e metodológica da comunicação comunitária.

Resumen Se trata de una publicación realizada por el Área de Comunicación Comunitaria de la Facultad de Ciencias de la Educación de la Universidad Nacional de Entre Ríos que resume los 16 años de trayectoria de trabajo en el territorio. A través de la sistematización de experiencias, el libro propone socializar herramientas y recursos utilizados en procesos de intervención social, implementados en diferentes contextos, desde la perspectiva teórica y metodológica de la comunicación comunitaria.

Abstract This is a publication carried out by the Community Communication Area of the Faculty of Educational Sciences of the National University of Entre Ríos that summarizes the 16-year history of work in the territory.Through the systematization of experiences, the book proposes to socialize tools and resources used in social intervention processes, implemented in different contexts, from the theoretical and methodological perspective of community communication.

11.

Recomendaciones de manejo de los anticoagulantes orales directos (DOACs) anti Xa y anti IIa
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Ceresetto, José M.

; Tajer, Carlos

; Duboscq, Cristina

; Bottaro, Federico

; Casais, Patricia

; Korin, Jorge

; Fondevila, Carlos

; Giumelli, Carla

; Scazziota, Alejandra

; Rossi, Andrea

; Botto, Fernando

; Ariscancela, Maria Ester

; Martinuzzo, Marta

; Zaidel, Ezequiel

; Fitz Maurice, Mario

; Bahit, Cecilia

; Vazquez, Fernando

; Molnar, Soledad

; Saizberg, Simón

; Negri Aranguren, Pedro

; Rosa, Claudio

; Fedele, José Luis

; Comignani, Pablo

; Pombo, Gonzalo

; Raña, Pablo

; Adamczuk, Yolanda

; Martí, Alejandra

; Charask, Adrián

; Penchasky, Diana

; Riveros, Dardo

; Mariani, Javier

; Puente, Dolores

; Celebrin, Lucia

; Bosio, Martín

; Brodsky, Andrés

; Sanchez Lucero, Analía

; Castillo Costa, Yanina

; Hirschson, Alfredo

; Arbesú, Guillermo

; Viñuales, Susana

; Kazelian, Lucía

; Maneyro, Alberto

; Gutierrez, Victoria

; Castro Rios, Miguel

; Gagliardi, Juan

; Lescano, Adrián

; Repetto, Fernanda

Medicina (Buenos Aires)

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apr 2022, Volume 82 Suppl. 2 Pages 1 - 55

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Abstract Direct oral anticoagulants have emerged as the drugs that have changed the man agement of the antithrombotic treatment in the last 15 years. Their advantages, like a more friendly way of anticoagulation and their lower risk of bleeding, especially in the brain, have positioned these new anticoagu lants as the first drug of choice in the two most frequent indications of anticoagulation, atrial fibrillation, and the venous thromboembolic disease. However, not all the patients can receive these agents, not all the direct oral anticoagulants have the same characteristics, and most importantly, not all the diseases with an indication of an anticoagulant drug can be treated with them. Therefore, it is mandatory that all the faculties involved in the management of these drugs must know them in depth, to decide the best treatment for the patient. This position paper, from a group of experts in anticoagulation in Argentina, can help the general practitioner in the daily use of direct oral anticoagulants based on the new evidence and the experience of a wide group of professionals. The way we relate to the anticoagulant treatment has changed in the last years. The doctors who work with them must also do so.

Resumen Los anticoagulantes orales directos han surgido como una de las herramientas que ha cambiado el manejo de la enfermedad trombótica en los últimos 15 años. Sus ventajas, desde el punto de vista de la facilidad de uso y menor riesgo de sangrado, especialmente de sangrado cerebral, han posicionado a estos nuevos anticoagulantes como la primera alternativa de tratamiento en las dos indicaciones más frecuentes en que necesitamos estas drogas, la fibrilación auricular y la enfermedad tromboembólica venosa. Sin embargo, no todos los pacientes pueden recibir estos agentes, no todos los anticoagulantes directos tienen las mismas pro piedades y fundamentalmente, no todas las enfermedades con indicación de un anticoagulante pueden tratarse con ellos;con lo cual es necesario que todos los profesionales que están involucrados en el manejo de estos medicamentos estén obligados a conocerlos en profundidad, para poder decidir el mejor tratamiento en cada caso particular. Este documento de posición de expertos de diferentes especialidades de Argentina, presenta lineamientos para el uso correcto de los anticoagulantes directos en base a nueva evidencia y a la experiencia de uso de un amplio grupo de profesionales. La forma de relacionarnos con el tratamiento anticoagulante ha cambiado. Los médicos que trabajamos con ellos también debemos hacerlo.

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12.

Authentic Leadership Questionnaire aplicado a enfermeiros brasileiros: evidências de validade
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Maziero, Vanessa Gomes

; Rocha, Fernanda Ludmilla Rossi

; Campos, Juliana Alvares Duarte Bonini

; Dias, Bruna Moreno

; Balsanelli, Alexandre Pazetto

; Gabriel, Carmen Silvia

; Bernardes, Andrea

Revista Latino-Americana de Enfermagem

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2022, Volume 30 elocation e3607

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

Resumo Objetivo: estimar as propriedades psicométricas do Authentic Leadership Questionnaire (ALQ) aplicado a enfermeiros brasileiros. Método: estudo observacional transversal com amostragem não probabilística. As propriedades psicométricas das versões RATER e SELF do ALQ foram estimadas utilizando-se análise fatorial confirmatória com método de estimação robusto WLSMV. Como índices de qualidade de ajustamento dos modelos, foram utilizados: razão do qui-quadrado pelos graus de liberdade (χ2/gl), Tucker-Lewis Index (TLI), Comparative Fit Index (CFI), Root Mean Square Error of Aproximation (RMSEA) e Standardized Root Mean Squared Residual (SRMR). A confiabilidade dos dados foi analisada por meio do coeficiente alfa ordinal e da confiabilidade composta. Resultados: participaram 181 enfermeiros (sexo feminino: 80,1%; média de idade de 34,6 anos; tempo de trabalho inferior a cinco anos: 76,3%). Os modelos completos da ALQ RATER e ALQ SELF não apresentaram ajustamento adequado. Porquanto, o modelo refinado apresentou melhor ajustamento para a amostra (ALQ RATER: χ2/gl=2,77; CFI=0,97; TLI=0,97; RMSEA=0,10; SRMR=0,05; ALQ SELF: χ2/gl=2,74; CFI=0,94; TLI=0,92; RMSEA=0,10; SRMR=0,08). No modelo ALQ RATER, foram removidos os itens 1, 7 e 13. Devido à alta correlação entre os fatores Transparência Relacional e Perspectiva Moral, foi proposto um modelo trifatorial com base na junção dos fatores acima citados. No modelo ALQ SELF, foram retirados os itens 2, 5, 9 e 10. Do mesmo modo, foi proposto um modelo trifatorial baseado na junção de dois fatores agora denominado Equilíbrio Autoconsciência. Conclusão: os dados obtidos com Authentic Leadership Questionnaire com enfermeiros brasileiros foram válidos e confiáveis.

Abstract Objective: to establish the psychometric properties of the Authentic Leadership Questionnaire (ALQ) applied to Brazilian nurses. Method: cross-sectional observational study with a non-probabilistic sample. The psychometric properties of the RATER and SELF versions of the ALQ were calculated using confirmatory factor analysis with the WLSMV robust estimation method. The following indices were used to assess the goodness-of-fit of the model: chi-square by degrees of freedom (χ2/df), Tucker-Lewis Index (TLI), Comparative Fit Index (CFI), Root Mean Square Error of Approximation (RMSEA) and Standardized Root Mean Squared Residual (SRMR). Data reliability was analyzed using the ordinal coefficient alpha and composite reliability. Results: 181 nurses participated of the study (female gender: 80.1%; mean age of 34.6 years; working time of less than five years: 76.3%). The complete ALQ RATER and ALQ SELF models did not present an adequate fit. Therefore, the refined models presented a better fit to the sample data (ALQ RATER: χ2/df=2.77; CFI=0.97; TLI=0.97; RMSEA=0.10; SRMR=0.05; ALQ SELF: χ2/df=2.74; CFI=0.94; TLI=0.92; RMSEA=0.10; SRMR=0.08). In the ALQ RATER model, items 1, 7 and 13 were excluded. Due to the high correlation between the factors Relational Transparency and Moral Perspective, a three-factor model based on the combination of the factors mentioned above was proposed. In the ALQ SELF model, items 2, 5, 9 and 10 were excluded. Likewise, a three-factor model based on the combination of two factors, now called Self-Awareness Balance, was proposed. Conclusion: the data obtained with the Authentic Leadership Questionnaire with Brazilian nurses were valid and reliable.

Resumen Objetivo: estimar las propiedades psicométricas del Authentic Leadership Questionnaire (ALQ) aplicado a enfermeros brasileños. Método: estudio observacional transversal con muestreo no probabilístico. Las propiedades psicométricas de las versiones RATER y SELF del ALQ se estimaron mediante análisis factorial confirmatorio con el método de estimación robusta WLSMV. Como índices de calidad de ajuste de los modelos se utilizó: razón de chi-cuadrado por grados de libertad (χ2/gl), Tucker-Lewis Index (TLI), Comparative Fit Index (CFI), Root Mean Square Error of Approximation (RMSEA) y Standardized Root Mean Squared Residual (SRMR). La confiabilidad de los datos se analizó mediante el coeficiente alfa ordinal y la confiabilidad compuesta. Resultados: participaron 181 enfermeros (sexo femenino: 80,1%; edad media de 34,6 años; tiempo de trabajo inferior a cinco años: 76,3%). Los modelos completos ALQ RATER y ALQ SELF no mostraron un ajuste adecuado. Por lo tanto, el modelo refinado presentó un mejor ajuste para la muestra (ALQ RATER: χ2/gl=2,77; CFI=0,97; TLI=0,97; RMSEA=0,10; SRMR=0,05; ALQ SELF: χ2/gl=2,74; CFI=0,94, TLI=0,92, RMSEA=0,10, SRMR=0,08). En el modelo ALQ RATER se eliminaron los ítems 1, 7 y 13. Debido a la alta correlación entre los factores Transparencia Relacional y Perspectiva Moral, se propuso un modelo de tres factores basado en la unión de los factores mencionados anteriormente. En el modelo ALQ SELF se eliminaron los ítems 2, 5, 9 y 10. Asimismo, se propuso un modelo trifactorial basado en la unión de dos factores, ahora denominado Equilibrio de Autoconciencia. Conclusión: los datos obtenidos con el Authentic Leadership Questionnaire con enfermeros brasileños fueron válidos y confiables.

https://doi.org/10.1590/1518-8345.5868.3607

13.

Products with organic certification: do Brazilian consumers perceive their attributes?
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Lima, Anderson Rodolfo de

; Scalco, Andrea Rossi

; Ganga, Gilberto Miller Devós

Production

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2022, Volume 32 elocation e20220024

Abstract: En | Text: En | PDF: En

Abstract Paper Aims This work aims to identify the socio-environmental attributes related to the label ‘Brazilian Organic Product – BOP- perceived by consumers of organic foods. Originality This paper is pioneering in the understanding of the attributes of BOP label in Brazil by consumers. Also, is unique in exploring the dimensions “organic’, “environmental” and “social” based on Brazilian law regarding organic food and the Guidelines of the Certifiers of Organic Products in Brazil. Research method A survey was conducted with 106 consumers of organic foods and an exploratory factor analysis (EFA) was carried out. Main findings Results showed that eight dimensions of attributes (Labor Laws and Social Incentive; Social and Environmental Practices; Environmental Management; Social and Environmental Protection; Environmental Preservation; Natural Products; Animal and Social Welfare; Non-renewable resources) influence consumer’s perception about the BOP label. Implications for theory and practice For theory this study shows how consumers perceive socio environmental attributes through labels and how this perception can motivate the purchase. For practice, intended to provide insights for marketing managers to better improve information on the labels Also, provide information to public policy managers to improve policies that can reach out more consumers.

https://doi.org/10.1590/0103-6513.20220024

14.

Caracterización de las solicitudes de importación de medicamentos vitales no disponibles años 2016 y 2017 en Colombia
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Olivares, Luz Andrea

; Vargas-Peláez, Claudia Marcela

; Lopez, Jose Julian

; Rossi, Francisco

; Chacón-Garzón, María Fernanda

Ciência & Saúde Coletiva

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nov 2021, Volume 26 N. 11 Pages 5441 - 5452

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Abstract This study analyzed the import applications for unavailable vital medicines (MVND) submitted to INVIMA and the records of MVND reimbursement requests submitted to the ADRES in the 2016-2017 period. Approximately 76% of the 2,321 MVND import applications were authorized. Eighty-eight applicants, 73 therapeutic subgroups, 195 active ingredients, and 368 diagnoses were identified. Most of the patients registered in the import applications (66%) are linked to the contributory regime, to a lesser extent to the subsidized regime and the Special or exceptional regimes. The total value of the reimbursement requests related to MVND granted by lawsuits, was USD 8,577,583, equivalent to 38,483 UPCs. The results showed that the implementation of Decree N° 481/2004 has ensured access to medicines for rare diseases. However, it is not alien to the structural inequality of access to health services and medicines of the Colombian Health System, which impacts public health and the allocated budget, either because of the high cost of importing MVND or because of the lack of MVND regulation within the national market.

Resumen En este estudio se analizaron las solicitudes de importación de Medicamentos vitales no disponibles (MVND) presentadas al INVIMA y los registros de solicitudes de recobros presentados en la ADRES por MVND, en el periodo 2016-2017. De las 2321 solicitudes de importación de MVND, el 76% fueron autorizadas. Se identificaron 88 solicitantes, 73 subgrupos terapéuticos y 195 principios activos, así como 368 diagnósticos. El 66% de los pacientes registrados en las solicitudes de importación se encuentran vinculados al régimen contributivo, en menor proporción al régimen subsidiado y al régimen especial o excepcional. En solicitudes de recobros asociados a MVND por vía judicial, se observó que, el monto solicitado por recobro fue de USD 8.577.583, equivalentes a 38483 UPCs. Los resultados mostraron que la implementación del decreto 481 de 2004 ha sido útil para garantizar el acceso a medicamentos para enfermedades raras, aunque no es ajena a la inequidad estructural de acceso a servicios de salud y medicamentos del SGSSS y que generan impacto, no solo en la salud pública, si no en el presupuesto asignado, bien sea por el alto costo que implica su importación o por la falta de regulación de estos dentro del mercado nacional.

https://doi.org/10.1590/1413-812320212611.15642021

15.

Multibiomarker responses in Danio rerio after exposure to sediment spiked with triclosan
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SAGER, EMANUEL

; ROSSI, ANDREA

; LOUGHLIN, TOMÁS MAC

; MARINO, DAMIÁN

; TORRE, FERNANDO DE LA

Anais da Academia Brasileira de Ciências

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2021, Volume 93 elocation e20201938

Abstract: En | Text: En | PDF: En

Abstract Triclosan (TCS) is an antimicrobial and antimycotic agent widely used in personal care products. In aquatic environments, both TCS and its biomethylated more persistent form, methyl-triclosan (MeTCS), are usually detected in wastewater effluents and rivers, where are commonly adsorbed to suspended solids and sediments. The aim of this study was to evaluate biochemical and physiological effects in Danio rerio after a short term (2 days) and prolonged (21 days) exposures to sediment spiked with TCS acting as the source of the pollutant in the assay. The activities of catalase (CAT), glutathione-s transferase (GST) and superoxide dismutase (SOD), lipid peroxidation levels (LPO), total capacity against peroxyl radicals (ACAP), and acetylcholinesterase enzymatic activity (AChE) were measured in liver, gills, and brain. Most of TCS on the spiked sediment was biotransformed to MeTCS and promoted different adverse effects on D. rerio. Gills were the most sensitive organ after 2 day-exposure, showing lipid damage and increased SOD activity. After 21 days of exposure, liver was the most sensitive organ, showing lower ACAP, increased LPO levels, and SOD and CAT activities. This is the first study reporting the effects on biochemical markers in D. rerio from a MeTCS sink resulting from sediment spiked with TCS.

https://doi.org/10.1590/0001-3765202120201938 79 downloads

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