Resumen Este artículo tiene como objetivo presentar y discutir el proceso de elaboración de la planificación de la comunicación interna del Núcleo de Comunicação, de la Subsecretaría de Asuntos Administrativos, órgano vinculado a la Secretaría Ejecutiva y a la Coordenação Geral de Documentação e Informação do Ministério da Saúde do Brasil. El trabajo se realizó entre 2022 y 2023 en el ámbito del Programa de Extensión denominado CAPAGIIC-Saúde, promovido por Universidade Federal do Rio Grande do Sul, Porto Alegre, basado en la metodología de aprendizaje–servicio. El proceso de elaboración de la planificación de la comunicación interna se desarrolló desde una perspectiva participativa e integrada, con el objetivo de mejorar la relación entre los actores de los órganos involucrados. En general, se concluye que la planificación estratégica de la comunicación interna puede ofrecer buenas condiciones para estructurar el trabajo en equipo y para un mejor diálogo con los directivos.

Abstract This article aims to present and discuss the process of preparing the internal communication planning of the Núcleo de Comunicação, of the Subsecretaria de Assuntos Administrativos, a department linked to the Secretaria Executiva and the Coordenação Geral de Documentação e Informação of the brazilian Ministério da Saúde. The work was carried out between 2022 and 2023 within the scope of the Extension Program called CAPAGIIC-Saúde, promoted by Universidade Federal do Rio Grande do Sul – Porto Alegre, based on the service-learning methodology. The process of preparing internal communication planning was developed from a participatory and integrated perspective, aiming to improve the relationship between the stakeholders of the bodies involved. In general, it is concluded that strategic internal communication planning can offer good conditions for structuring team work and for better dialogue with managers.

Resumo Este artigo tem como objetivo apresentar e discutir o processo de elaboração do planejamento interno de comunicação do Núcleo de Comunicação, da Subsecretaria de Assuntos Administrativos, órgão vinculado à Secretaria Executiva e à Coordenação Geral de Documentação e Informação do Ministério da Saúde do Brasil. O trabalho foi realizado entre os anos de 2022 e de 2023 no escopo do Programa de Extensão denominado CAPAGIIC-Saúde, promovido pela Universidade Federal do Rio Grande do Sul – Porto Alegre, a partir da metodologia de service-learning. O processo de elaboração do planejamento interno de comunicação foi desenvolvido na perspectiva participativa e integrada, visando à melhoria do relacionamento entre os públicos de interesse das instâncias envolvidas. De forma geral, conclui-se que o planejamento estratégico de comunicação interna pode oferecer boas condições para a estruturação do trabalho de equipes e para um melhor diálogo com gestores.

Abstract Objective: To study the association between placental efficiency with anthropometry and nutritional phenotypes in full-term newborns from a birth cohort. Method: This was a secondary cross-sectional analysis of data obtained in a cohort study (Brazilian RibeirãoPreto and São Luís Birth Cohort Studies - BRISA), whose deliveries were performed between 2010 and 2011. Standardized questionnaires were applied to mothers, and placentas and newborns were evaluated shortly after delivery. Placental efficiency was assessed using the ratio between birth weight and placental weight (BW/PW ratio); values below the lower quartile (25th percentile for gestational age) were considered to have low placental efficiency. Newborn phenotypes were small and large for gestational age, stunted and wasted, evaluated using the INTERGROWTH-21 growth standard. To identify the confounding variables theoretical model was constructed using Directed Acyclic Graphs, and unadjusted and adjusted logistic regression were performed. Placental measurements were obtained blindly from pregnancy and delivery data. Results: 723 mother-placenta-child triads were studied. 3.2 % of newborns were small-for-gestational-age (SGA), 6.5 %large-for-gestational-age (LGA), 5.7 %had stunting, and 0.27 % wasting. A significantly higher risk was found between low placental efficiency and SGA (OR 2.82;95 % CI 1.05-7.57), stunting (OR 2.23; 95 % CI 1.07-4.65), and wasting (OR 8.22; 95 % CI 1.96-34.37). No relationship was found between LGA and placental efficiency. Conclusions: Low placental efficiency was associated with increased risk for small-for-gestational-age, stunting, and wasting. Placental morphometry can provide valuable information on intrauterine conditions and neonatal health, helping to identify newborns at higher risk of future comorbidities. Objective fullterm full term Method crosssectional cross sectional Brazilian BRISA, BRISA , BRISA) 201 2011 mothers BW/PW BWPW BW PW ratio) 25th th age wasted INTERGROWTH21 INTERGROWTH 21 INTERGROWTH-2 standard Graphs Results 72 motherplacentachild mother placenta child studied 32 3 2 3. smallforgestationalage SGA, (SGA) 65 6 5 6. %largeforgestationalage largeforgestationalage %large LGA, (LGA) 57 7 5. had 027 0 27 0.2 OR 2.8295 28295 2.82 82 2.82;9 1.057.57, 105757 1.05 7.57 1 05 1.05-7.57) 2.23 223 23 9 1.074.65, 107465 1.07 4.65 07 4 1.07-4.65) 8.22 822 8 22 1.9634.37. 1963437 1.96 34.37 . 96 34 37 1.96-34.37) Conclusions smallforgestationalage, health comorbidities 20 INTERGROWTH2 INTERGROWTH- (SGA (LGA 02 0. 8295 2.829 2829 282 2.8 2.82; 057 1.057.57 10575 105 1.0 757 7.5 1.05-7.57 2.2 074 1.074.65 10746 107 465 4.6 1.07-4.65 8.2 9634 1.9634.37 196343 196 1.9 3437 34.3 1.96-34.37 829 28 2. 1.057.5 1057 10 1. 75 7. 1.05-7.5 1.074.6 1074 46 4. 1.07-4.6 8. 963 1.9634.3 19634 19 343 34. 1.96-34.3 1.057. 1.05-7. 1.074. 1.07-4. 1.9634. 1963 1.96-34. 1.057 1.05-7 1.074 1.07-4 1.9634 1.96-34 1.05- 1.07- 1.963 1.96-3 1.96-

Abstract Dental referrals to the Endodontics Specialty Clinic (ESC) are routine owing to the complexity of endodontic treatments. To obtain a better prognosis for treatment, students/dentists must perceive their technical limits. This study sought to investigate the referrals of patients to the ESC from different clinics of the Piracicaba Dental School, State University of Campinas - SP, Brazil, and check: a) the demographic profile of patients and the most commonly affected tooth; b) the clinic with the largest number of referrals; c) the reasons for referrals; d) the complexity of the cases; e) and the difficulty in assessing the referred cases based on the classification provided by the American Association of Endodontists (AAE) and Souza-Filho. The study sample consisted of patients’ electronic dental referral records from February 2015 to June 2019. A total of 1,707 patients were referred to the ESC during the study period, and 62.4% were female. Lower molars were the most frequently involved teeth (34.8%), and 60.7% of the cases were referred due to the presence of root curvature. The AAE classification showed prevalence of highly difficult cases (71.3%), whereas Souza-Filho classification demonstrated a high rate of class III cases (85.8%). This study highlights the difficulties encountered by undergraduate students before or during endodontic treatments, reinforcing the need for clear criteria for selecting cases appropriate for each education level, thus improving endodontic treatment prognosis. (ESC treatments studentsdentists dentists limits School SP Brazil check tooth b c d e (AAE SouzaFilho. SouzaFilho Souza Filho. Filho 201 2019 1707 1 707 1,70 period 624 62 4 62.4 female 34.8%, 348 34.8% , 34 8 (34.8%) 607 60 7 60.7 curvature 71.3%, 713 71.3% 71 3 (71.3%) 85.8%. 858 85.8% . 85 (85.8%) level 20 170 70 1,7 6 62. 34.8 (34.8% 60. 71.3 (71.3% 85.8 (85.8% 2 17 1, 34. (34.8 71. (71.3 85. (85.8 (34. (71. (85. (34 (71 (85 (3 (7 (8 (

Abstract The total cost of processes that use lipases can be reduced by using the mycelium or not purified crude extract with lipolytic activity. These catalysts can be used without complex purification and can show desirable properties to emerging applications like hydrolysis and biotransformation of vegetable oils. To explore the potential of multiple forms of lipases (produced by the same filamentous fungus species), this work investigated intracellular and extracellular lipases produced by Trichoderma koningii (intracellular lipases were never studied), Penicillium spp. F02 (isolated from industrial grease trap) and Aspergillus niger. For this, batch fermentations were conducted for 96h using olive oil as a carbon source. The submerged culture was interrupted with vacuum filtration to isolate the mycelium and crude extract. The lipolytic activities were determined by the hydrolysis method of olive oil. The best results were obtained for intracellular activity with T. koningii (81.5 U/g of dry biomass) and for extracellular activity with A. niger (10.6 U/mL of crude extract). Both were attained in 96h of fermentation. T. koningii showed an accumulation of intracellular lipases and a depreciated extracellular activity in the initial 24 hours, which can be reasonable indications that there is strong retention of lipases in the mycelium. Statistical analysis within the range of 37°C to 44°C associated with pH from 7.8 to 8.0 favored the activity of lipases from T. koningii. All these findings are promising for future studies in the enzymatic synthesis of biodiesel with lipases (intracellular and extracellular) from T. koningii. oils species, species , species) studied, studied studied) spp F F0 isolated trap h source T 81.5 815 81 5 (81. Ug U g biomass A 10.6 106 10 6 (10. UmL mL . extract) fermentation 2 hours 37C C 37 44C 44 78 7 8 7. 80 0 8. 81. (81 10. 1 (10 3 4 (8 (1 (

Abstract Studies investigating the effects of different modalities of exercises on the immune system are scarce. Therefore, the aim of this study was to compare the effects of eight weeks of resistance and aerobic training on the proliferation of T and B lymphocytes from mice. Eighteen male C56BL6/J mice were divided into groups (n=6), sedentary, aerobic, and resistance training. After 8 weeks, animals were euthanized, and their splenocytes were labeled and cultured with and without stimulation. Lymphocyte proliferation (CD4+, CD8+ and CD21/CD35+) was evaluated by flow cytometry. The mice subjected to resistance exercise exhibited greater proliferation for total, CD8+ and B lymphocytes (p<0.05), but not CD4+ cells (p>0.05), compared with their sedentary counterparts. We found significant correlations between maximum load and total, CD8+ and B lymphocytes proliferation rates (p<0.05). In conclusion, our results showed that resistance training promoted an improvement in the immune response associated with CD8+ and B lymphocytes. scarce Therefore C56BL6J CBLJ C56BL6 J C BL n=6, n6 n n=6 , 6 (n=6) euthanized stimulation CD4+, CD4 CD (CD4+ CD8 CD21/CD35+ CD21CD35 CDCD CD21 CD35 cytometry total p<0.05, p005 p p<0.05 0 05 (p<0.05) p>0.05, p>0.05 (p>0.05) counterparts p<0.05. . conclusion CBL C56BL n= (n=6 (CD4 CD21/CD35 CD21CD3 CD2 CD3 p00 p<0.0 (p<0.05 p>0.0 (p>0.05 (n= (CD CD21/CD3 CD21CD p0 p<0. (p<0.0 p>0. (p>0.0 (n CD21/CD p<0 (p<0. p>0 (p>0. p< (p<0 p> (p>0 (p< (p> (p

ABSTRACT The characterization of cut flowers plays a significant role in detecting senescence signals, which are essential for establishing quality parameters and guiding the development of postharvest technologies. This study aimed to morphologically characterize Red Torch Ginger inflorescences at three harvest points: fully closed, semi-open, and fully open. The inflorescences were standardized at 60 cm, and their width, length, diameter, and fresh weight were measured. Inflorescences were evaluated for visual senescence, wettability, natural wax content, and fluid behavior. Dominant color, gloss, and texture were analyzed using GroundEye. Morphological differences affected the postharvest durability of Red Torch Ginger, with fully open inflorescences being less durable than semi-open and fully closed ones. Hydrophobicity, high-fluid movement, and natural wax content were crucial for decision-making regarding the application of new postharvest technologies and coatings in cut tropical flowers. These findings provide insights into the characterization of cut flowers and their postharvest behavior, which can help improve quality and extend the shelf life of cut flowers, leading to increased economic benefits for the flower industry. signals points semiopen, semiopen semi open, 6 cm width length diameter measured wettability behavior color gloss GroundEye ones Hydrophobicity highfluid high movement decisionmaking decision making industry

ABSTRACT Rocky Mountain Spotted Fever is a rickettsial disease caused by the bacteria Rickettsia rickettsii. In Brazil, the disease is known as Brazilian spotted fever (BSF), being the most significant tick-borne disease in the country. Among the affected patients, only 5% of cases occur in children aged one to nine years. Typical symptoms of the disease are fever, rash, headache and digestive symptoms. Neurological manifestations such as seizures, aphasia and hemiparesis have been described in few patients. This study aimed to describe the case of an infant diagnosed with BSF who presented severe signs of neurological manifestation. rickettsii Brazil BSF, , (BSF) tickborne tick borne country patients 5 years rash seizures manifestation (BSF

ABSTRACT Hematopoietic stem cell transplant (HSCT) recipients are at -increased risk for severe COVID-19. The aim of this study was to evaluate the burden of COVID-19 in a cohort of HSCT recipients. This retrospective study evaluated a cohort of adult hospitalized HSCT recipients diagnosed with COVID-19 in two large hospitals in São Paulo, Brazil post-HSCT, from January 2020 to June 2022. The primary outcome was all-cause mortality. Of 49 cases, 63.2% were male with a median age of 47 years. Allogeneic-HSCT (51.2%) and autologous-HSCT (48.9%) patients were included. The median time from HSCT to COVID-19 diagnosis was 398 days (IQR: 1211-134), with 22 (44.8%) cases occurring within 12 months of transplantation. Most cases occurred during the first year of the pandemic, in non-vaccinated patients (n=35; 71.4%). Most patients developed severe (24.4%) or critical (40.8%) disease; 67.3% received some medication for COVID-19, primarily corticosteroids (53.0%). The probable invasive aspergillosis prevalence was 10.2%. All-cause mortality was 40.8%, 51.4% in non-vaccinated patients and 14.2% in patients who received at least one dose of the vaccine. In the multiple regression analyses, the variables mechanical ventilation (OR: 101.01; 95% CI: 8.205 – 1,242.93; p = 0.003) and chest CT involvement at diagnosis ≥50% (OR: 26.61; 95% CI: 1.06 – 664.26; p = 0.04) remained associated with all-cause mortality. Thus, HSCT recipients with COVID-19 experienced high mortality, highlighting the need for full vaccination and infection prevention measures. (HSCT increased COVID19. COVID19 COVID 19. 19 COVID-1 Paulo postHSCT, postHSCT post HSCT, post-HSCT 202 2022 allcause all cause 4 632 63 2 63.2 years AllogeneicHSCT Allogeneic 51.2% 512 51 (51.2% autologousHSCT autologous 48.9% 489 48 9 (48.9% included 39 IQR (IQR 1211134, 1211134 1211 134 , 1211-134) 44.8% 448 44 8 (44.8% 1 transplantation pandemic nonvaccinated non vaccinated n=35 n35 n 35 (n=35 71.4%. 714 71.4% . 71 71.4%) 24.4% 244 24 (24.4% 40.8% 408 40 (40.8% disease 673 67 3 67.3 COVID19, 19, 53.0%. 530 53.0% 53 0 (53.0%) 102 10 10.2% Allcause All 514 51.4 142 14 14.2 vaccine analyses OR (OR 101.01 10101 101 01 95 CI 8205 205 8.20 1,242.93 124293 242 93 0.003 0003 003 50 ≥50 26.61 2661 26 61 106 06 1.0 664.26 66426 664 0.04 004 04 Thus measures COVID1 COVID- 20 6 63. 51.2 5 (51.2 48.9 (48.9 121113 121 13 1211-134 44.8 (44.8 n=3 n3 (n=3 71.4 7 24.4 (24.4 40.8 (40.8 67. 53.0 (53.0% 10.2 51. 14. 101.0 1010 820 8.2 1,242.9 12429 0.00 000 00 ≥5 26.6 266 1. 664.2 6642 66 0.0 (51. 48. (48. 12111 1211-13 44. (44. n= (n= 71. 24. (24. 40. (40. 53. (53.0 10. 101. 82 8. 1,242. 1242 ≥ 26. 664. 0. (51 (48 1211-1 (44 (n (24 (40 (53. 1,242 124 (5 (4 1211- (2 (53 1,24 ( 1,2 1,

RESUMO Há suficientes evidências de que os resultados de um programa de restauração dependem em grande parte do contexto da paisagem. Os usos e coberturas prévios da terra e a paisagem devem ser considerados nos projetos de restauração, pois influenciam todo o processo, especialmente na dispersão de sementes e na regeneração natural das áreas. Neste trabalho verificou-se o efeito da paisagem (uso do solo) no sucesso da restauração em áreas de plantio total, semeadura direta e de regeneração natural no bioma Mata Atlântica, sudeste do Brasil. A metodologia baseou-se em unidades demonstrativas de restauração, com foco nos indicadores de riqueza e abundância de regenerantes, juntamente com dados de uso e cobertura da terra das áreas entre os anos de 2010, 2015 e 2020, obtidos das Coleções MapBiomas. Aplicou-se modelos lineares generalizados e análise de correlação entre os dados. Nossa hipótese era que uma paisagem com mais cobertura florestal e de regeneração natural (mosaico de agricultura e pastagem) afetariam positivamente os regenerantes em locais restaurados, o que observamos apenas em áreas de tratamento de regeneração natural. Nos locais de restauração ativa, o mosaico de agricultura e pastagem foi negativamente associado e o uso agricultura foi positivamente associado aos regenerantes. Encontramos maior abundância e riqueza de regenerantes em locais de regeneração natural do que semeadura direta e plantio de mudas. A influência da paisagem, nomeadamente do mosaico, desempenhou um papel crucial neste sucesso. Além disso, o uso da terra, conforme observamos nos últimos cinco e dez anos, explicou os regenerantes nos locais estudados. Assim, os resultados mostram que o contexto paisagístico e o histórico anterior de uso do solo são essenciais para compreender as limitações à sucessão e definir estratégias de restauração custo-efetivas. processo verificouse verificou se total Atlântica Brasil baseouse baseou 2010 201 2020 MapBiomas Aplicouse Aplicou restaurados ativa mudas disso estudados Assim custoefetivas. custoefetivas custo efetivas. efetivas custo-efetivas 20 202 2

ABSTRACT There is good evidence that the results of a restoration program depend largely on the landscape context. In restoration projects, it is crucial to consider the previous land uses and covers and landscape configuration as they have a significant impact on the entire process, especially seed dispersal and natural regeneration of sites. Thus, the objective of this work was to verify the effect of landscape (i.e., land use) on restoration success of total planting, seed sowing and natural regeneration sites in the Atlantic Forest biome, southeast Brazil. The methodology employed was based on demonstration units of restoration. The focus was on regenerant richness and abundance indicators, along with land use and land cover data (class area) from 2010, 2015, and 2020, obtained from the MapBiomas Project. Generalized linear models and correlation analysis were used for the study. We hypothesize that a landscape with more forest and natural regeneration cover (mosaic of agriculture and pasture) would positively affect regenerants in restored sites, which we only observed for natural regeneration treatment sites. In active restoration treatment sites, mosaic of agriculture and pasture was negatively and farming was positively associated to regenerants. We also found greater density and richness of regenerants in natural regeneration treatment sites than in seed sowing and seedling planting. The influence of the surrounding landscape, particularly mosaic, played a crucial role in this success. In addition, land use cover history, as we observed in classes in the last five and ten years, did explain regenerants in studied sites. Thus, results show that the characterization of landscape context and previous land-use history is essential to understand the limitations to succession and define cost-effective restoration strategies. projects process Thus i.e., ie i e (i.e. planting biome Brazil indicators class area 2010 2015 2020 Project study addition years landuse costeffective cost effective strategies i.e. (i.e 201 202 i.e 20 2

RESUMO Contexto: Algumas pessoas apresentam recorrentemente dificuldades para engolir medicamentos sólidos, o que pode estar associado ao tamanho do medicamento, à idade e ao gênero dos indivíduos. Objetivo: Avaliar, em adultos, o impacto do tamanho da cápsula, da idade e do gênero no trânsito oral e faríngeo de cápsulas. Métodos: Videofluoroscopia foi utilizada para medir o trânsito oral e faríngeo de cápsulas em 49 indivíduos saudáveis (17 homens e 32 mulheres), com idade média de 46 anos (limites de 23 e 88 anos). Cápsulas menores foram preenchidas com 0,50 mL e cápsulas maiores foram preenchidas com 0,95 mL de sulfato de bário; o volume de líquido ingerido com as cápsulas foi quantificado em cada ingestão. Foram medidos o tempo de preparo oral, tempo de trânsito oral, tempo de reação da deglutição, tempo para fechamento do vestíbulo laríngeo, tempo de fechamento do vestíbulo laríngeo, tempo de trânsito faríngeo e tempo de abertura do esfíncter superior do esôfago. Resultados: O tamanho da cápsula não influenciou o tempo de trânsito oral ou faríngeo. Mais líquido foi ingerido com cápsulas maiores e por pessoas com mais de 40 anos. O tempo de trânsito oral foi menor em idosos (60-88 anos) e o tempo de fechamento do vestíbulo laríngeo foi maior em mulheres. Conclusão: O tamanho da cápsula não influenciou o trânsito oral e faríngeo, porém houve maior volume de líquido ingerido com a cápsula maior e nos mais idosos. O trânsito oral da cápsula foi mais rápido em indivíduos com mais de 60 anos. Contexto sólidos medicamento Objetivo Avaliar adultos Métodos 4 17 (1 3 mulheres, mulheres , mulheres) limites 2 8 . 050 0 50 0,5 095 95 0,9 bário ingestão deglutição esôfago Resultados 6088 (60-8 Conclusão 6 1 ( 05 5 0, 09 9 608 (60- (60 (6

ABSTRACT Background: People recurrently have difficulties swallowing solid medications, which can be associated with the size of the medication and the age and gender of individuals. Objective: To evaluate the impact of capsule size and adults’ age and gender on oral and pharyngeal capsule transit during capsule swallows. Methods: Videofluoroscopy was used to measure capsule oral and pharyngeal transit during swallows in 49 healthy individuals (17 men and 32 women), with a mean age of 46 years (ranging from 23 to 88 years). Smaller capsules were filled with 0.50 mL of barium sulfate, and larger capsules were filled with 0.95 mL of barium sulfate; the volume of liquid ingested with the capsules was also quantified in each ingestion. The measurements included the oral preparation time, oral transit time, swallowing reaction time, time to laryngeal vestibule closure, laryngeal vestibule closure duration, pharyngeal transit time, and upper esophageal sphincter opening duration. Results: The capsule size did not influence either the oral or pharyngeal transit time. Increased liquid volume was ingested with larger capsules and by people older than 40 years. The oral transit time was shorter in older adults (60-88 years), and the time to laryngeal vestibule closure was longer in women. Conclusion: The size of large capsules did not make a difference in oral or pharyngeal transit when compared with smaller capsules. The capsule size and the participant’s age influenced the volume of liquid ingested - larger capsules and older individuals required a larger volume. The capsule oral transit was faster in individuals older than 60 years. Background medications Objective Methods 4 17 (1 3 women, women , women) ranging 2 8 . years) 050 0 50 0.5 sulfate 095 95 0.9 ingestion duration Results 6088 (60-8 years, Conclusion participants participant s 6 1 ( 05 5 0. 09 9 608 (60- (60 (6

Abstract This study aimed to evaluate the influence of the Er,Cr:YSGG irradiation and 980-nm diode lasers on the surface roughness (SR) and volume loss (VL) of dentin subjected to cariogenic challenge. Subsequently, 130 specimens of bovine dentin were divided into the following 13 groups: NT: no treatment; FG: fluoride gel; FV: fluoride varnish; Di: 980-nm diode; Di + FG; Di + FV; FG + D; FV + Di; Er: Er,Cr:YSGG; Er + FG; Er + FV; FG + Er and FV + Er. Er,Cr:YSGG laser parameters were as follows: 0.25 W; 5.0 Hz; 4.46 J/cm2 without water and 55% air. Furthermore, the 980-nm diode laser parameters were 2.0 W; 2.0 Hz; 21.41 J/cm2. The samples from each group were subjected to pH cycling. A confocal laser scanning microscope was used to evaluate SR and VL. Difference between the volume of the reference and treated areas + DES/RE was used to determine SR and VL. The mean values of the different groups were subjected to analysis of variance and Tukey’s post-hoc test. The VL values were analyzed using the Kruskal–Wallis and Dunn post-hoc test (p < 0.05). The SR of the reference area did not show a statistically significant 1807-3107-bor-38-e025treatment and cariogenic challenge (p > 0.05). Moreover, VL in the FV + Di and FV + Er groups showed a statistically significant difference compared with areas submitted to different types of treatment and cariogenic challenge (p > 0.05). Er,Cr:YSGG and 980-nm diode lasers associated with fluoride varnishes decreased dentin VL in bovine teeth submitted to cariogenic challenge. Er,CrYSGG ErCrYSGG Er,Cr YSGG Cr 980nm nm 980 (SR (VL Subsequently 1 NT gel varnish D follows 025 0 25 0.2 W 50 5 5. Hz 446 4 46 4.4 Jcm2 Jcm J cm2 cm J/cm 55 air Furthermore 20 2 2. 2141 21 41 21.4 cycling DESRE DES RE Tukeys Tukey s posthoc post hoc KruskalWallis Kruskal Wallis p 0.05. 005 0.05 . 05 0.05) 18073107bor38e025treatment boretreatment 1807 3107 bor 38 e025treatment e Moreover CrYSGG ErCr 98 02 0. 44 4. 214 21. 00 0.0 180 310 3 etreatment 9 18 31

RESUMO Objetivo: interpretar os sentidos atribuídos à qualidade de vida relacionada à saúde por cuidadoras de adolescentes com diabetes mellitus tipo 1. Métodos: estudo qualitativo, descritivo-exploratório desenvolvido no ambulatório de referência para doenças endócrinas em uma cidade da Paraíba com 14 cuidadoras de adolescentes com diabetes. As entrevistas ocorreram entre maio e setembro de 2021. O material empírico foi submetido à análise temática indutiva e interpretado à luz dos conceitos de qualidade de vida relacionada à saúde e do funcionamento familiar. Resultados: os sentidos atribuídos pelas cuidadoras à qualidade de vida relacionada à saúde dos adolescentes convergiram para sensação de estar com saúde, alimentação saudável, renda familiar satisfatória, envolvimento da família no cuidado e acesso efetivo à rede assistencial. Considerações Finais: o conhecimento destes sentidos possibilita que os profissionais de saúde elaborem estratégias que atendam às demandas singulares de cuidadores que vivenciam esse diagnóstico. Objetivo 1 Métodos qualitativo descritivoexploratório descritivo exploratório 2021 Resultados saudável satisfatória assistencial Finais diagnóstico 202 20 2

ABSTRACT Objective: to interpret the meanings attributed to the health-related quality of life by caregivers of adolescents with type 1 diabetes mellitus. Methods: qualitative, descriptive-exploratory study of 14 caregivers of adolescents with diabetes developed at the reference outpatient clinic for endocrine diseases in a city in the state of Paraíba. Interviews were performed between May and September 2021. Inductive thematic analysis of the empirical material, and its interpretation in light of the concepts of health-related quality of life and family functioning were performed. Results: the meanings attributed by caregivers to the health-related quality of life of adolescents converged on the feeling of being healthy, healthy eating, satisfactory family income, family involvement in care and effective access to the care network. Final Considerations: knowledge of these meanings enables health professionals to develop strategies that meet the unique demands of caregivers experiencing this diagnosis. Objective healthrelated related mellitus Methods qualitative descriptiveexploratory descriptive exploratory Paraíba 2021 material Results eating income network Considerations diagnosis 202 20 2

RESUMEN Objetivo: interpretar los significados atribuídos a la calidad de vida relacionada con la salud por cuidadores de adolescentes con diabetes mellitus tipo 1. Métodos: estudio cualitativo, descriptivo-exploratorio con 14 cuidadores de adolescentes con diabetes desarrollado en el ambulatorio de referencia para enfermedades endocrinas de una ciudad del estado de Paraíba. Las entrevistas se realizaron entre mayo y septiembre de 2021. Se realizó un análisis temático inductivo del material empírico y su interpretación a la luz de los conceptos de calidad de vida relacionada con la salud y funcionamiento familiar. Resultados: los significados atribuídos por los cuidadores a la calidad de vida relacionada con la salud de los adolescentes convergieron en el sentimiento de estar sano, alimentación saludable, ingreso familiar satisfactorio, involucramiento familiar en el cuidado y acceso efectivo a la red de cuidados. Consideraciones Finales: el conocimiento de estos significados permite a los profesionales de la salud desarrollar estrategias que atiendan las demandas únicas de los cuidadores que experimentan este diagnóstico. Objetivo 1 Métodos cualitativo descriptivoexploratorio descriptivo exploratorio Paraíba 2021 Resultados sano saludable satisfactorio cuidados Finales diagnóstico 202 20 2

ABSTRACT Purpose: To evaluate using a biocellulose-based hydrogel as an adjuvant in the healing process of arterial ulcers. Methods: A prospective single group quasi-experimental study was carried out with chronic lower limb arterial ulcer patients. These patients received biocellulose-based hydrogel dressings and outpatient guidance on dressing and periodic reassessments. The primary outcomes were the ulcer-healing rate and product safety, which were assessed by ulcer area measured in photographic records of pre-treatment and posttreatment after 7, 30, and 60 days. Secondary outcomes were related to clinical assessment by the quality-of-life scores (SF-36 and EQ-5D) and pain, evaluated by the visual analogue scale (VAS). Results: Seventeen participants were included, and one of them was excluded. Six patients (37%) had complete wound healing, and all patients had a significant reduction in the ulcer area during follow-up (233.6mm2 versus 2.7mm2) and reduction on the score PUSH 3.0 (p < 0.0001). The analysis of the SF-36 and EQ-5D questionnaires showed a statistically significant improvement in almost all parameters analyzed and with a reduction of pain assessed by the VAS. Conclusions: The biocellulose-based hydrogel was safe and showed a good perspective to promoting the necessary conditions to facilitate partial or complete healing of chronic arterial ulcers within a 60-day follow-up. Quality of life and pain were positively affected by the treatment. Purpose biocellulosebased biocellulose based Methods quasiexperimental quasi experimental reassessments ulcerhealing safety pretreatment pre treatment 7 30 6 days qualityoflife quality SF36 SF 36 (SF-3 EQ5D EQD EQ 5D D VAS . (VAS) Results included excluded 37% 37 (37% followup follow up 233.6mm2 2336mm2 mm 233 6mm2 (233.6mm 2.7mm2 27mm2 2 7mm2 3 0 3. p 0.0001. 00001 0.0001 0001 0.0001) SF-3 Conclusions 60day day followup. up. SF3 (SF- (VAS (37 233.6mm 2336mm 23 6mm 2.7mm 27mm 7mm 0000 0.000 000 SF- (SF (3 0.00 00 ( 0.0 0.