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Abstract Introduction The Iowa-Netherlands Comparison Orientation Measure (INCOM) was developed to measure individual differences in social comparison orientation and has been widely used in research and various different settings. Objectives The aim of this study was to adapt the online version of the INCOM and to evaluate its psychometric parameters when applied to a Brazilian population of university students. Methods The procedures were divided into two steps: step 1 – cross-cultural adaptation and analysis of content validity, and step 2 – assessment of psychometric characteristics. Step 1 comprised the processes of translation, evaluation by an expert committee, evaluation by the target population, and back-translation. For step 2, 1,065 university students were recruited and then factor analysis, analysis of reliability, and analysis of validity based on external measures were performed. Results The adaptation process yielded satisfactory results, including good indicators of content validity. Exploratory factor analysis revealed a two-dimensional structure and adequate factor loadings, except for item 11, which was excluded from the final version. Additionally, the final version of the scale had adequate fit indices (χ2 = 148.45, degrees of freedom [df] = 26; p < 0.001; root mean square error of approximation [RMSEA] = 0.06; comparative fit index [CFI] = 0.99; and Tucker-Lewis index [TLI] = 0.98). Evidence of reliability (Cronbach’s alpha = 0.83) was observed and there were positive correlations with negative affect (r = 0.36) and negative correlations with positive affect and self-esteem (r = -0.15; r = -0.41, respectively). Conclusion The Brazilian version of the INCOM presents satisfactory psychometric parameters and can thus be used to measure social comparison orientation. IowaNetherlands Iowa Netherlands (INCOM settings steps crosscultural cross cultural characteristics translation committee backtranslation. backtranslation back translation. back-translation 1065 065 1,06 performed results twodimensional dimensional loadings 11 Additionally χ2 χ (χ 14845 148 45 148.45 df [df 26 0.001 0001 0 001 RMSEA [RMSEA 0.06 006 06 CFI [CFI 0.99 099 99 TuckerLewis Tucker Lewis TLI [TLI 0.98. 098 0.98 . 98 0.98) Cronbachs Cronbach s 0.83 083 83 0.36 036 36 selfesteem self esteem 0.15 015 15 -0.15 0.41, 041 41 -0.41 respectively. respectively respectively) 106 1,0 1484 14 4 148.4 0.00 000 00 0.0 0.9 09 9 0.8 08 8 0.3 03 3 0.1 01 -0.1 0.41 04 -0.4 10 1, 148. 0. -0. 0.4 -0 -

https://doi.org/10.47626/2237-6089-2022-0573

To be or not to B27 positive: implications for the phenotypes of axial spondyloarthritis outcomes. Data from a large multiracial cohort from the Brazilian Registry of Spondyloarthritis B B2 positive outcomes
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Resende, Gustavo Gomes

; Saad, Carla Goncalves Schahin

; Marques, Claudia Diniz Lopes

; Ribeiro, Sandra Lúcia Euzébio

; Gavi, Maria Bernadete Renoldi de Oliveira

; Yazbek, Michel Alexandre

; Marinho, Adriana de Oliveira

; Menin, Rita de Cássia

; Ochtrop, Manuella Lima Gomes

; Soares, Andressa Miozzo

; Cavalcanti, Nara Gualberto

; Carneiro, Jamille Nascimento

; Werner de Castro, Glaucio Ricardo

; Fernandes, José Mauro Carneiro

; Souza, Elziane da Cruz Ribeiro E

; Alvarenga, Corina Quental de Menezes

; Vieira, Rejane Maria Rodrigues de Abreu

; Machado, Natalia Pereira

; Ximenes, Antônio Carlos

; Gazzeta, Morgana Ohira

; Albuquerque, Cleandro Pires de

; Skare, Thelma Larocca

; Keiserman, Mauro Waldemar

; Kohem, Charles Lubianca

; Benacon, Gabriel Sarkis

; Rocha, Vítor Florêncio Santos

; Lage, Ricardo da Cruz

; Malheiro, Olivio Brito

; Golebiovski, Rywka Tenenbaum Medeiros

; Oliveira, Thauana Luiza

; Duque, Ruben Horst

; Londe, Ana Carolina

; Pinheiro, Marcelo de Medeiros

; Sampaio-Barros, Percival Degrava

Advances in Rheumatology

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2024, Volume 64 elocation 33

Abstract: En | Text: En | PDF: En

Abstract Background There is a remarkable variability in the frequency of HLA-B27 positivity in patients with spondyloarthritis (SpA), which may be associated with different clinical presentations worldwide. However, there is a lack of data considering ethnicity and sex on the evaluation of the main clinical and prognostic outcomes in mixed-race populations. The aim of this study was to evaluate the frequency of HLA-B27 and its correlation with disease parameters in a large population of patients from the Brazilian Registry of Spondyloarthritis (RBE). Methods The RBE is a multicenter, observational, prospective cohort that enrolled patients with SpA from 46 centers representing all five geographic regions of Brazil. The inclusion criteria were as follow: (1) diagnosis of axSpA by an expert rheumatologist; (2) age ≥18 years; (3) classification according to ASAS axial. The following data were collected via a standardized protocol: demographic data, disease parameters and treatment historical. Results A total of 1096 patients were included, with 73.4% HLA-B27 positivity and a mean age of 44.4 (±13.2) years. Positive HLA-B27 was significantly associated with male sex, earlier age at disease onset and diagnosis, uveitis, and family history of SpA. Conversely, negative HLA-B27 was associated with psoriasis, higher peripheral involvement and disease activity, worse quality of life and mobility. Conclusions Our data showed that HLA-B27 positivity was associated with a classic axSpA pattern quite similar to that of Caucasian axSpA patients around the world. Furthermore, its absence was associated with peripheral manifestations and worse outcomes, suggesting a relevant phenotypic difference in a highly miscegenated population. HLAB27 HLAB HLA B27 B HLA-B2 SpA, , (SpA) worldwide However mixedrace mixed race populations RBE. . (RBE) multicenter observational 4 Brazil follow 1 (1 rheumatologist 2 (2 18 ≥1 years 3 (3 axial protocol historical 109 included 734 73 73.4 444 44 44. ±13.2 132 13 (±13.2 uveitis Conversely psoriasis activity mobility world Furthermore HLAB2 B2 HLA-B (SpA (RBE ( ≥ 10 7 73. ±13. (±13. ±13 (±13 ±1 (±1 ± (±

https://doi.org/10.1186/s42358-024-00372-0

Usefulness of prolactin levels in predicting the etiology of hyperprolactinemia in a cohort of 770 patients 77 7
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Vilar, Lucio

; Vilar, Clarice Freitas

; Lyra, Ruy

; Albuquerque, Luciano

; Garrido, Ana Carolina Thé

; Gadelha, Patrícia Sampaio

; Diniz, Erik Trovão

; Almeida, Marcos

; Cordeiro, Lucia Helena

; Carvalho, Erico Higino de

; Melo, Ana Teresa Bezerra de

; Medeiros, Karoline Matias

; Ferreira, Gabriel Rodrigues de Assis

; Mororó Neto, José Coelho

; Ximenes, Daniela Zago

; Madruga, Camila Ribeiro Coutinho

; Nunes, Rosália de Oliveira

; Sá, Yanna Queiroz Pereira de

; Naves, Luciana Ansaneli

Archives of Endocrinology and Metabolism

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2024, Volume 68 elocation e230391

Abstract: En | Text: En | PDF: En

ABSTRACT Objective Determining the etiology of hyperprolactinemia is fundamental for selecting the most appropriate treatment strategy. The aim of this study was to evaluate the usefulness and accuracy of prolactin levels in predicting the etiology of nonphysiological hyperprolactinemia. Subjects and methods In this retrospective study, we reviewed medical records of patients with nonphysiological hyperprolactinemia seen at two neuroendocrine reference centers located in Recife, Brazil, from January 2000 to December 2019. Results The study included 770 patients aged 12-73 years (65% female). The three most frequent etiologies of hyperprolactinemia were prolactinomas (n = 263; 34.2%), drug-induced hyperprolactinemia (n = 160; 20.8%), and macroprolactinemia (n = 120; 15.6%). The highest mean prolactin levels were observed in cases of prolactinomas and idiopathic hyperprolactinemia. Most patients with hyperprolactinemia due to other etiologies had prolactin levels < 100 ng/mL, but these levels were also found in 16.5% of patients with microproplactinomas and in 20% of those with idiopathic hyperprolactinemia. Likewise, prolactin levels largely overlapped among patients with microprolactinomas, macroprolactinemia, and drug-induced hyperprolactinemia. Notably, prolactin levels > 250 ng/mL enabled a clear distinction between the etiologies of macroprolactinoma and nonfunctioning pituitary adenoma. Moreover, prolactin levels > 500 ng/mL were highly suggestive of macroprolactinomas, although they were also found in very few patients (<2%) with microprolactinomas or drug-induced hyperprolactinemia. Conclusion Despite considerable overlap in prolactin levels among the different etiologies of hyperprolactinemia, values > 250 ng/mL allowed a clear distinction between macroprolactinomas and nonfunctioning pituitary adenomas. Furthermore, prolactin levels > 500 ng/mL were almost exclusively found in patients with prolactinomas. strategy Recife Brazil 200 2019 77 1273 12 73 12-7 65% 65 (65 female. female . female) n 263 34.2%, 342 34.2% , 34 2 34.2%) druginduced drug induced 160 20.8%, 208 20.8% 20 8 20.8%) 120 15.6%. 156 15.6% 15 6 15.6%) 10 ngmL ng mL 165 16 5 16.5 Likewise Notably 25 adenoma Moreover 50 <2% (<2% adenomas Furthermore 201 7 127 1 12- (6 26 34.2 3 20.8 15.6 16. <2 (<2 ( 34. 20. 15. (<

https://doi.org/10.20945/2359-4292-2023-0391

Safety of CoronaVac and ChAdOx1 vaccines against SARS-CoV-2 in patients with rheumatoid arthritis: data from the Brazilian multicentric study safer ChAdOx SARSCoV2 SARSCoV SARS CoV 2 SARS-CoV- arthritis SARS-CoV
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Cruz, Vitor Alves

; Guimarães, Camila

; Rêgo, Jozelia

; Machado, Ketty Lysie Libardi Lira

; Miyamoto, Samira Tatiyama

; Burian, Ana Paula Neves

; Dias, Laiza Hombre

; Pretti, Flavia Zon

; Batista, Danielle Cristina Filgueira Alves

; Mill, José Geraldo

; Oliveira, Yasmin Gurtler Pinheiro de

; Gadelha, Carolina Strauss Estevez

; Gouveia, Maria da Penha Gomes

; Moulin, Anna Carolina Simões

; Souza, Bárbara Oliveira

; Aguiar, Laura Gonçalves Rodrigues

; Vieira, Gabriel Smith Sobral

; Grillo, Luiza Lorenzoni

; Lima, Marina Deorce de

; Pasti, Laís Pizzol

; Surlo, Heitor Filipe

; Faé, Filipe

; Moulaz, Isac Ribeiro

; Macabú, Mariana de Oliveira

; Ribeiro, Priscila Dias Cardoso

; Magalhães, Vanessa de Oliveira

; Aguiar, Mariana Freitas de

; Biegelmeyer, Erika

; Peixoto;, Flávia Maria Matos Melo Campos

; Kayser, Cristiane

; Souza, Alexandre Wagner Silva de

; Castro, Charlles Heldan de Moura

; Ribeiro, Sandra Lúcia Euzébio

; Telles, Camila Maria Paiva França

; Bühring, Juliana

; Lima, Raquel Lima de

; Santos, Sérgio Henrique Oliveira Dos

; Dias, Samuel Elias Basualto

; Melo, Natália Seixas de

; Sanches, Rosely Holanda da Silva

; Boechat, Antonio Luiz

; Sartori, Natália Sarzi

; Hax, Vanessa

; Dória, Lucas Denardi

; Rezende, Rodrigo Poubel Vieira de

; Baptista, Katia Lino

; Fortes, Natália Rodrigues Querido

; Melo, Ana Karla Guedes de

; Melo, Tâmara Santos

; Vieira, Rejane Maria Rodrigues de Abreu

; Vieira, Adah Sophia Rodrigues

; Kakehasi, Adriana Maria

; Tavares, Anna Carolina Faria Moreira Gomes

; Landa, Aline Teixeira de

; Costa, Pollyana Vitoria Thomaz da

; Azevedo, Valderilio Feijó

; Martins-Filho, Olindo Assis

; Peruhype-Magalhães, Vanessa

; Pinheiro, Marcelo de Medeiros

; Monticielo, Odirlei André

; Reis-neto, Edgard Torres Dos

; Ferreira, Gilda Aparecida

; Souza, Viviane Angelina de

; Teixeira-Carvalho, Andréa

; Xavier, Ricardo Machado

; Sato, Emilia Inoue

; Valim, Valeria

; Pileggi, Gecilmara Salviato

; Silva, Nilzio Antonio da

Advances in Rheumatology

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2024, Volume 64 elocation 58

Abstract: En | Text: En | PDF: En

Abstract Background Patients with immune-mediated rheumatic diseases (IMRDs) have been prioritized for COVID-19 vaccination to mitigate the infection severity risks. Patients with rheumatoid arthritis (RA) are at a high risk of severe COVID-19 outcomes, especially those under immunosuppression or with associated comorbidities. However, few studies have assessed the safety of the COVID-19 vaccine in patients with RA. Objective To evaluate the safety of vaccines against SARS-CoV-2 in patients with RA. Methods This data are from the study “Safety and Efficacy on COVID-19 Vaccine in Rheumatic Diseases,” a Brazilian multicentric prospective phase IV study to evaluate COVID-19 vaccine in IMRDs in Brazil. Adverse events (AEs) in patients with RA of all centers were assessed after two doses of ChAdOx1 (Oxford/AstraZeneca) or CoronaVac (Sinovac/Butantan). Stratification of postvaccination AEs was performed using a diary, filled out daily and returned at the end of 28 days for each dose. Results A total of 188 patients with RA were include, 90% female. CoronaVac was used in 109 patients and ChAdOx1 in 79. Only mild AEs were observed, mainly after the first dose. The most common AEs after the first dose were pain at the injection (46,7%), headache (39,4%), arthralgia (39,4%), myalgia (30,5%) and fatigue (26,6%), and ChAdOx1 had a higher frequency of pain at the injection (66% vs 32 %, p < 0.001) arthralgia (62% vs 22%, p < 0.001) and myalgia (45% vs 20%, p < 0.001) compared to CoronaVac. The more common AEs after the second dose were pain at the injection (37%), arthralgia (31%), myalgia (23%), headache (21%) and fatigue (18%). Arthralgia (41,4% vs 25%, p = 0.02) and pain at injection (51,4% vs 27%, p = 0.001) were more common with ChAdOx1. No serious AEs were related. With Regard to RA activity level, no significant difference was observed between the three time periods for both COVID-19 vaccines. Conclusion In the comparison between the two immunizers in patients with RA, local reactions and musculoskeletal symptoms were more frequent with ChAdOx1 than with CoronaVac, especially after the first dose. In summary, the AE occurred mainly after the first dose, and were mild, like previous data from others immunizing agents in patients with rheumatoid arthritis. Vaccination did not worsen the degree of disease activity. immunemediated immune mediated (IMRDs COVID19 COVID 19 COVID-1 risks (RA outcomes comorbidities However SARSCoV2 SARSCoV SARS CoV 2 SARS-CoV- Safety Diseases, Diseases Brazil (AEs ChAdOx Oxford/AstraZeneca OxfordAstraZeneca Oxford AstraZeneca (Oxford/AstraZeneca Sinovac/Butantan. SinovacButantan Sinovac/Butantan . Sinovac Butantan (Sinovac/Butantan) diary 18 include 90 female 10 79 46,7%, 467 46,7% , 46 7 (46,7%) 39,4%, 394 39,4% 39 4 (39,4%) 30,5% 305 30 5 (30,5% 26,6%, 266 26,6% 26 6 (26,6%) 66% 66 (66 3 % 0.001 0001 0 001 62% 62 (62 22 22% 45% 45 (45 20 20% 37%, 37 37% (37%) 31%, 31 31% (31%) 23%, 23 23% (23%) 21% 21 (21% 18%. 18% (18%) 41,4% 414 41 (41,4 25 25% 0.02 002 02 51,4% 514 51 (51,4 27 27% related level summary COVID1 1 COVID- SARS-CoV (Sinovac/Butantan 9 46,7 (46,7% 39,4 (39,4% 30,5 (30,5 26,6 (26,6% (6 0.00 000 00 (4 (37% (31% (23% (21 (18% 41,4 (41, 0.0 51,4 (51, 46, (46,7 39, (39,4 30, (30, 26, (26,6 ( (37 (31 (23 (2 (18 41, (41 0. 51, (51 (46, (39, (30 (26, (3 (1 (5 (46 (39 (26

https://doi.org/10.1186/s42358-024-00397-5

Influência da cobertura/do uso do solo sobre a hidrodinâmica do reservatório da Usina Hidrelétrica de Barra Grande, SC coberturado cobertura Grande
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Guedes, Damião Maciel

; Marques, David Motta

; Rodrigues, Lúcia Helena Ribeiro

; Bravo, Juan Martín

; Fragoso Júnior, Carlos Ruberto

; Cavalcanti, José Rafael

Engenharia Sanitaria e Ambiental

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2023, Volume 28 elocation e20220057

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO A influência da cobertura/do uso do solo da bacia hidrográfica sobre o reservatório da Usina Hidrelétrica de Barra Grande (lago artificial alongado, profundo em ambiente de cânion) foi analisada por meio de modelagem matemática utilizando o modelo de grandes bacias (MGB-IPH) para estimativa de vazões, o HEC-RAS para qualidade da água e o IPH-ECO na simulação do reservatório. A modelagem da simulação da alteração da cobertura do solo mostrou que a substituição de florestas por outros usos causou aumento nas vazões e nas cargas de nitrogênio total e fósforo total, e a substituição de outros usos por florestas resultou em redução nas vazões e nas cargas de nitrogênio total e fósforo total. A magnitude da anomalia da carga de nutrientes está associada ao grau de alteração causado no processo de transformação da precipitação em escoamento superficial, à declividade do terreno, aos tipos de solo e às práticas de uso do solo. A bacia hidrográfica apresenta solos rasos em 86% de sua área, com declividades do terreno acentuadas nas cabeceiras, o que facilita o escoamento para o reservatório. Anomalias positivas foram estimadas quando agricultura substitui outros usos e anomalias negativas quando áreas de agricultura são substituídas. A carga de nutrientes que chega ao reservatório está relacionada ao grau de alteração no processo de transformação da precipitação em escoamento superficial, à declividade do terreno, aos tipos de solo e às práticas de uso do solo adotadas. Há estratificação térmica na porção mais profunda, com mistura no inverno, quando a operação da usina pode influenciar a mistura na coluna d’água, com efeito oposto entre a região próxima à barragem e as demais regiões mais distantes da barragem, dependendo das condições de temperatura, vazão e tempo de residência. Esse conhecimento é importante para a gestão do reservatório. coberturado lago alongado cânion MGBIPH MGB IPH (MGB-IPH HECRAS HEC RAS IPHECO ECO superficial 86 área cabeceiras substituídas adotadas profunda inverno dágua, dágua d água, d’água temperatura residência 8

ABSTRACT The influence of the soil cover of the watershed that contributes to a watershed on the Barra Grande Hydroelectric Power Plant reservoir (subtropical, elongated, and “canyon”) was carried out through mathematical modeling (MGB-IPH for flows, HEC-RAS for water quality, and IPH -ECO for reservoir simulation). Simulation modeling of land cover change showed that replacing forests with other uses caused an increase in flows and loads of total nitrogen and total phosphorus and replacing other uses with forests resulted in a reduction in flows and loads of total nitrogen and total phosphorus. The magnitude of the nutrient load anomaly is associated with the degree of alteration caused in the process of transforming precipitation into surface runoff, terrain slope, soil types, and land use practices. The watershed has shallow soils in 86% of its area, with steep slopes at the headwaters, which facilitates the flow into the reservoir. Positive anomalies were estimated when agriculture replaces other uses and negative anomalies when agricultural areas are replaced. The nutrient load that reaches the reservoir is related to the degree of change in the process of transforming precipitation into surface runoff, the slope of the terrain, the types of soil, and land use practices adopted. There is thermal stratification in the deepest portion, with mixing in winter, where the operation of the plant can influence the mixing in the water column, with opposite effect between the region close to the dam and the other regions further away from the dam, depending on the conditions of temperature, flow, and residence time. Knowledge of structure and function is important to improve reservoir management. subtropical, subtropical (subtropical elongated canyon “canyon” MGBIPH MGB HECRAS HEC RAS quality ECO simulation. simulation . simulation) runoff 86 area headwaters replaced adopted portion winter column temperature time management “canyon 8

https://doi.org/10.1590/s1413-415220220057

Factors associated with anemia and vitamin A deficiency in Brazilian children under 5 years old: Brazilian National Survey on Child Nutrition (ENANI-2019) old ENANI2019 ENANI 2019 (ENANI-2019 ENANI201 201 (ENANI-201 ENANI20 20 (ENANI-20 ENANI2 2 (ENANI-2 (ENANI- (ENANI
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Castro, Inês Rugani Ribeiro de

; Normando, Paula

; Farias, Dayana Rodrigues

; Berti, Talita Lelis

; Schincaglia, Raquel Machado

; Andrade, Pedro Gomes

; Bertoni, Neilane

; Lacerda, Elisa Maria de Aquino

; Anjos, Luiz Antonio dos

; Boccolini, Cristiano Siqueira

; Reis, Marta Citelli dos

; Bezerra, Flávia Fioruci

; Pedrosa, Lucia Fatima Campos

; Jordão Junior, Alceu Afonso

; Lira, Pedro Israel Cabral de

; Kac, Gilberto

; Vertulli Carneiro, Letícia B.

; Alves-Santos, Nadya Helena

Cadernos de Saúde Pública

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2023, Volume 39 Suppl. 2 elocation e00194922

Abstract: Es Pt En | Text: Es Pt En | PDF: Es | PDF: Pt | PDF: En

resumen está disponible en el texto completo

Resumo: Fatores associados a anemia e deficiência de vitamina A foram investigados em 7.716 crianças de 6-59 meses de idade parte da Estudo Nacional de Alimentação e Nutrição Infantil (ENANI-2019). Adotamos uma abordagem hierárquica baseada em um modelo teórico do Fundo das Nações Unidas para a Infância (UNICEF) com três níveis estratificados por idade (6-23; 24-59 meses). Foram estimadas razões de prevalência (RP) e intervalos de 95% de confiança (IC95%). Determinantes habilitadores: observamos maior prevalência de anemia em crianças de 6-23 meses de idade cujas mães tinham ≤ 7 anos de escolaridade (RP = 1,92; IC95%: 1,10; 3,34), < 20 anos de idade (RP = 2,47; IC95%: 1,34; 4,56) ou 20-30 anos de idade (RP = 1,95; IC95%: 1,11; 3,44), cor parda (RP = 1,57; IC95%: 1,06; 2,23); e em crianças de 24-59 meses de idade na Região Norte (RP = 3,11; IC95%: 1,58; 6,13). Encontramos maior prevalência de deficiência de vitamina A em crianças de 6-23 meses de idade no Centro-oeste (RP = 2,32; IC95%: 1,33; 4,05) e em crianças de 24-59 meses de idade residentes nas regiões Norte (RP = 1,96; IC95%: 1,16; 3,30), Sul (RP = 3,07; IC95%: 1,89; 5,01) e Centro-oeste (RP = 1,91; IC95%: 1,12; 3,25) cujas mães tinham entre 20-34 anos de idade (RP = 1,62; IC95%: 1,11; 2,35). Determinantes subjacentes: a presença de mais de uma criança < 5 anos de idade no domicílio se associou a maior prevalência de anemia (RP = 1,61; IC95%: 1,15; 2,25) e deficiência de vitamina A (RP = 1,82; IC95%: 1,09; 3,05) em crianças de 6-23 meses de idade. Determinantes imediatos: o consumo de 1-2 grupos de alimentos ultraprocessados em crianças de 24-59 meses de idade (RP = 0,44; IC95%: 0,25; 0,81) e o não aleitamento materno no dia anterior em crianças de 6-23 meses de idade (RP = 0,56; IC95%: 0,36; 0,95) foram associados com a menor prevalência de anemia e deficiência de vitamina A. Políticas públicas focadas em grupos geográfica e socialmente vulneráveis são necessárias para promover equidade. Resumo 7716 716 7.71 659 6 59 6-5 ENANI2019. ENANI2019 ENANI 2019 . (ENANI-2019) UNICEF (UNICEF 623 23 (6-23 2459 24 24-5 meses. meses) RP 95 IC95%. IC95 IC IC95% (IC95%) habilitadores 6-2 1,92 192 1 92 1,10 110 10 3,34, 334 3,34 , 3 34 3,34) 2 2,47 247 47 1,34 134 4,56 456 4 56 2030 30 20-3 1,95 195 1,11 111 11 3,44, 344 3,44 44 3,44) 1,57 157 57 1,06 106 06 2,23 223 2,23) 3,11 311 1,58 158 58 6,13. 613 6,13 13 6,13) Centrooeste Centro oeste 2,32 232 32 1,33 133 33 4,05 405 05 1,96 196 96 1,16 116 16 3,30, 330 3,30 3,30) 3,07 307 07 1,89 189 89 5,01 501 01 1,91 191 91 1,12 112 12 3,25 325 25 2034 1,62 162 62 2,35. 235 2,35 35 2,35) subjacentes 1,61 161 61 1,15 115 15 2,25 225 1,82 182 82 1,09 109 09 3,05 305 imediatos 1- 0,44 044 0 0,25 025 0,81 081 81 0,56 056 0,36 036 36 0,95 095 equidade 771 71 7.7 65 6- ENANI201 201 (ENANI-2019 (6-2 245 24- 9 IC9 (IC95% 1,9 19 1,1 3,3 2,4 1,3 4,5 45 203 20- 3,4 1,5 1,0 2,2 22 3,1 31 6,1 2,3 4,0 40 3,0 1,8 18 8 5,0 50 3,2 1,6 0,4 04 0,2 02 0,8 08 0,5 0,3 03 0,9 77 7. ENANI20 (ENANI-201 (6- (IC95 1, 3, 2, 4, 6, 5, 0, ENANI2 (ENANI-20 (6 (IC9 (ENANI-2 ( (IC (ENANI- (ENANI

Abstract: Factors associated with anemia and vitamin A deficiency were investigated in 7,716 children 6-59 months of age studied in the Brazilian National Survey on Child Nutrition (ENANI-2019). We adopted a hierarchical approach based on a United Nations Children’s Fund (UNICEF) theoretical model with three levels, stratifying by age (6-23; 24-59 months). Prevalence ratio (PR) and 95% confidence interval (95%CI) were estimated. Enabling determinants: a higher prevalence of anemia was observed in children 6-23 months whose mothers had ≤ 7 years of schooling (PR = 1.92; 95%CI: 1.10; 3.34), < 20 years old (PR = 2.47; 95%CI: 1.34; 4.56) or 20-30 years old (PR = 1.95; 95%CI: 1.11; 3.44), mixed-race (PR = 1.57; 95%CI: 1.06; 2.23); and in children 24-59 months in the North Region (PR = 3.11; 95%CI: 1.58; 6.13). A higher prevalence for vitamin A deficiency was observed in children 6-23 months from Central-West (PR = 2.32; 95%CI: 1.33; 4.05), and in children 24-59 months living in the North (PR = 1.96; 95%CI: 1.16; 3.30), South (PR = 3.07; 95%CI: 1.89; 5.01), and Central-West (PR = 1.91; 95%CI: 1.12; 3.25) and whose mothers were 20-34 years (PR = 1.62; 95%CI: 1.11; 2.35). Underlying determinants: the presence of more than one child < 5 years old in the household was associated with a higher prevalence of anemia (PR = 1.61; 95%CI: 1.15; 2.25) and vitamin A deficiency (PR = 1.82; 95%CI: 1.09; 3.05) in children 6-23 months. Immediate determinants: consumption of 1-2 groups of ultra-processed foods in children 24-59 months (PR = 0.44; 95%CI: 0.25; 0.81) and lack of breastfeeding in the day before in children 6-23 months (PR = 0.56; 95%CI: 0.36; 0.95) were associated with lower prevalence of anemia and vitamin A deficiency. Public policies focused on geographically and socially vulnerable groups are needed to promote equity. Abstract 7716 716 7,71 659 6 59 6-5 ENANI2019. ENANI2019 ENANI 2019 . (ENANI-2019) Childrens Children s UNICEF (UNICEF levels 623 23 (6-23 2459 24 24-5 months) PR 95 95%CI 95CI CI (95%CI estimated determinants 6-2 1.92 192 1 92 1.10 110 10 3.34, 334 3.34 , 3 34 3.34) 2 2.47 247 47 1.34 134 4.56 456 4 56 2030 30 20-3 1.95 195 1.11 111 11 3.44, 344 3.44 44 3.44) mixedrace mixed race 1.57 157 57 1.06 106 06 2.23 223 2.23) 3.11 311 1.58 158 58 6.13. 613 6.13 13 6.13) CentralWest Central West 2.32 232 32 1.33 133 33 4.05, 405 4.05 05 4.05) 1.96 196 96 1.16 116 16 3.30, 330 3.30 3.30) 3.07 307 07 1.89 189 89 5.01, 501 5.01 01 5.01) 1.91 191 91 1.12 112 12 3.25 325 25 2034 1.62 162 62 2.35. 235 2.35 35 2.35) 1.61 161 61 1.15 115 15 2.25 225 1.82 182 82 1.09 109 09 3.05 305 1- ultraprocessed ultra processed 0.44 044 0 0.25 025 0.81 081 81 0.56 056 0.36 036 36 0.95 095 equity 771 71 7,7 65 6- ENANI201 201 (ENANI-2019 (6-2 245 24- 9 1.9 19 1.1 3.3 2.4 1.3 4.5 45 203 20- 3.4 1.5 1.0 2.2 22 3.1 31 6.1 2.3 40 4.0 3.0 1.8 18 8 50 5.0 3.2 1.6 0.4 04 0.2 02 0.8 08 0.5 0.3 03 0.9 77 7, ENANI20 (ENANI-201 (6- 1. 3. 2. 4. 6. 5. 0. ENANI2 (ENANI-20 (6 (ENANI-2 ( (ENANI- (ENANI

https://doi.org/10.1590/0102-311xen194922

Factors associated with anemia and vitamin A deficiency in Brazilian children under 5 years old: Brazilian National Survey on Child Nutrition (ENANI-2019)
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Castro, Inês Rugani Ribeiro de

; Normando, Paula

; Farias, Dayana Rodrigues

; Berti, Talita Lelis

; Schincaglia, Raquel Machado

; Andrade, Pedro Gomes

; Bertoni, Neilane

; Lacerda, Elisa Maria de Aquino

; Anjos, Luiz Antonio dos

; Boccolini, Cristiano Siqueira

; Reis, Marta Citelli dos

; Bezerra, Flávia Fioruci

; Pedrosa, Lucia Fatima Campos

; Jordão Junior, Alceu Afonso

; Lira, Pedro Israel Cabral de

; Kac, Gilberto

; Vertulli Carneiro, Letícia B.

; Alves-Santos, Nadya Helena

Cadernos de Saúde Pública

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2023, Volume 39 Suppl. 2 elocation e00194922

Abstract: Pt Es En | Text: Pt Es En | PDF: Pt | PDF: Es | PDF: En

resumen está disponible en el texto completo

https://doi.org/10.1590/0102-311xen194922

Projeções de vazão para avaliação de estimativa de carga de nutrientes afluentes à lagoa Mangueira, Rio Grande do Sul, em cenários de mudanças climáticas do Quinto Relatório de Avaliação das Mudanças Climáticas
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Felizzola, Nathalia Mendes

; Fernandes, Leonardo Facini

; Bravo, Juan Martin

; Sanagiotto, Daniela

; Rodrigues, Lúcia Helena Ribeiro

; Marques, David Manuel Lelinho da Motta

Engenharia Sanitaria e Ambiental

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oct 2022, Volume 27 N. 5 Pages 1007 - 1020

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO As mudanças climáticas podem causar alterações drásticas nos ecossistemas lacustres especialmente em razão da elevação da temperatura e das alterações na precipitação, provocando, entre outros fatores, aumento no aporte de nutrientes e, consequentemente, eutrofização. Este trabalho apresenta a estimativa de projeções de vazão e carga de nutrientes (NO3−, PO4–3) afluentes à lagoa Mangueira — grande lagoa rasa subtropical localizada no extremo sul do Brasil. As projeções foram baseadas nos produtos do Quinto Relatório de Avaliação das Mudanças Climáticas (AR5), no Representative Concentration Pathway — RCP 2.6, RCP 4.5 e RCP 8.5. Em cada cenário, foram utilizados produtos de até 39 modelos climáticos globais para a estimativa das projeções das variáveis em dois períodos futuros de 30 anos, centrados em 2030 (próximo) e 2070 (longo). Os resultados mostram como situação mais provável o aumento das vazões, com maior concordância entre os produtos do AR5, quando comparados aos do Quarto Relatório de Avaliação das Mudanças Climáticas (AR4) estimados em trabalho anterior. Nas projeções de cargas de nutrientes também prevalece o padrão de aumento. Os nutrientes analisados apresentam elevação de carga média anual de 9,34% no futuro próximo e no RCP 2.6, enquanto no futuro longo e no RCP 8.5 esse valor se eleva para 22,48%. Medidas mitigadoras deverão ser previstas com o objetivo de reduzir a carga de nutrientes afluentes e manter o bom estado ecológico da lagoa.

ABSTRACT Climate change can cause drastic changes in lake ecosystems, especially due to the increase in temperature and changes in precipitation, promoting, among other factors, an increase in the nutrients input and, therefore, eutrophication. This paper estimated the projected flow and nutrients load (NO3−, PO4–3) at the Mangueira lake — a large subtropical shallow lake, located in southern Brazil. The projections were based on the AR5 products for RCP 2.6, RCP 4.5, and RCP 8.5 scenarios. In each scenario, data from as many as 39 global climate models were used to estimate the projected values of flow and nutrients in two 30-year time intervals centered at 2,030 (near future) and 2,070 (long future). Results show the increase in flow is more likely, with a greater agreement between AR5 products when compared to AR4 products estimated in previous work. The pattern of increase also prevails in the projections of nutrient loads. The nutrients analyzed show an average annual load increase of 9.34% in the near future and RCP 2.6 scenario, while in the long future and RCP 8.5 scenario, this value rises to 22.48%. Mitigation measures should be studied to reduce the nutrient inputs and to preserve a good ecological status of the lake.

https://doi.org/10.1590/s1413-415220210194

Initial evaluation in the climacteric
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Baccaro, Luiz Francisco Cintra

; Paiva, Lúcia Helena Simões da Costa

; Nasser, Elizabeth Jeha

; Valadares, Ana Lúcia Ribeiro

; Silva, Célia Regina da

; Nahas, Eliana Aguiar Petri

; Kulak Junior, Jaime

; Rodrigues, Márcio Alexandre Hipólito

; Albernaz, Marco Aurélio

; Wender, Maria Celeste Osório

; Mendes, Maria Célia

; Dardes, Rita de Cassia de Maio

; Strufaldi, Rodolfo

; Bocardo, Rogerio Cesar

; Pompei, Luciano de Melo

Revista Brasileira de Ginecologia e Obstetrícia

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may 2022, Volume 44 N. 5 Pages 548 - 556

Abstract: En | Text: En | PDF: En

https://doi.org/10.1055/s-0042-1750282

10.

Genitourinary Syndrome of Menopause
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Valadares, Ana Lúcia Ribeiro

; Kulak Junior, Jaime

; Paiva, Lúcia Helena Simões da Costa

; Nasser, Elizabeth Jeha

; Silva, Célia Regina da

; Nahas, Eliana Aguiar Petri

; Baccaro, Luiz Francisco Cintra

; Rodrigues, Márcio Alexandre Hipólito

; Albernaz, Marco Aurélio

; Wender, Maria Celeste Osório

; Mendes, Maria Célia

; Dardes, Rita de Cassia de Maio

; Strufaldi, Rodolfo

; Bocardo, Rogerio Cesar

; Pompei, Luciano de Melo

Revista Brasileira de Ginecologia e Obstetrícia

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mar 2022, Volume 44 N. 3 Pages 319 - 324

Abstract: En | Text: En | PDF: En

https://doi.org/10.1055/s-0042-1748463

11.

Serial album on Continuous Insulin Infusion System as an innovative educational technology in diabetes
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Brilhante, Raquel Rodrigues da Costa

; Moreira, Thereza Maria Magalhães

; Oliveira, Sherida Karanini Paz de

; Florêncio, Raquel Sampaio

; Pessoa, Vera Lúcia Mendes de Paula

; Cestari, Virna Ribeiro Feitosa

Revista Brasileira de Enfermagem

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2022, Volume 75 N. 5 elocation e20210277

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

RESUMO Objetivo: construir e validar conteúdo e aparência de álbum seriado sobre insulinoterapia por Sistema de Infusão Contínua. Método: estudo metodológico, realizado em três etapas em Fortaleza, Ceará, Brasil, nos meses de agosto a novembro de 2018. Realizou-se a construção do álbum seriado e a validação de conteúdo e aparência pelos especialistas, e avaliação do público-alvo. Calcularam-se Índice de Validade de Conteúdo e Índice de Concordância. Resultados: os juízes consideraram válidos o conteúdo e a aparência do álbum, o que representa que o material é adequado como tecnologia educativa. Os especialistas sugeriram ajustes, incorporados ao material para produção impressa da versão final. O público-alvo também avaliou de forma positiva o álbum seriado. Conclusão: percebemos que o álbum seriado foi considerado uma tecnologia educacional inovadora em diabetes, valiosa para a promoção do conhecimento sobre Sistema de Infusão Contínua de Insulina, com conteúdo rico, atualizado, aliado à clareza, formato adequado e ilustrações explicativas.

ABSTRACT Objective: to build and validate a serial album content and appearance on insulin therapy using a Continuous Infusion System. Method: a methodological study, carried out in three stages in Fortaleza, Ceará, Brazil, from August to November 2018. The serial album construction and content and appearance validity were carried out by experts, and assessment, by the target audience. Content Validity Index and Concordance Index were calculated. Results: the judges considered the serial album content and appearance to be valid, which means that the material is suitable as an educational technology. Experts suggested adjustments, incorporated into the material for print production of the final version. The target audience also assessed the serial album positively. Conclusion: we realized that the serial album was considered an innovative educational technology in diabetes, valuable for promoting knowledge about Continuous Insulin Infusion System, with rich, updated content, combined with clarity, suitable format and explanatory illustrations.

RESUMEN Objetivo: construir y validar el contenido y la apariencia de un álbum en serie sobre terapia con insulina utilizando un Sistema de Infusión Continua. Método: estudio metodológico, realizado en tres etapas en Fortaleza, Ceará, Brasil, de agosto a noviembre de 2018. La construcción del álbum en serie y la validación de contenido y apariencia fueron realizadas por los especialistas, y evaluación del público objetivo. Se calcularon el Índice de Validez de Contenido y el Índice de Concordancia. Resultados: los jueces consideraron válido el contenido y la apariencia del álbum, lo que significa que el material es apto como tecnología educativa. Los expertos sugirieron ajustes, incorporados al material para la producción impresa de la versión final. El público objetivo también evaluó positivamente el álbum en serie. Conclusión: percibimos que el álbum en serie fue considerado una tecnología educativa innovadora en diabetes, valiosa para la promoción del conocimiento sobre el Sistema de Infusión Continua de Insulina, con contenido rico y actualizado, combinado con claridad, formato adecuado e ilustraciones explicativas.

https://doi.org/10.1590/0034-7167-2021-0277

12.

Definition of water quality variability parameters and dynamics to improve management in a deep canyon type subtropical hydroelectric reservoir
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Guedes, Damião Maciel

; Rodrigues, Lucia Ribeiro

; Bravo, Juan Martin

; Marques, David Manuel Lelinho da Motta

; Fragoso Júnior, Carlos Ruberto

; Cavalcanti, José Rafael

; Nascimento, Glaucia

RBRH

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2022, Volume 27 elocation e13

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Os padrões de variabilidade espacial e temporal da qualidade da água foram avaliados através de coletas mensais de amostras de água (superfície, subsuperfície e fundo) de 2005 a 2012. A Análise de Componentes Principais foi utilizada para definir a importância relativa de cada variável e Anova (bidirecional) para analisar a significância das diferenças na qualidade da água no eixo longitudinal do reservatório. As variáveis: turbidez, transparência de Secchi, tempo de residência e temperatura têm maior importância na qualidade da água. Foram observados gradientes espaciais e temporais, relacionados aos processos de circulação, sedimentação e ressuspensão, e a influência da baixa vazão, alto tempo de residência e mistura invernal da coluna d'água na ciclagem de sólidos e nutrientes pode explicar a variação desses processos. A utilização de métodos de análise estatística multivariada forneceu informações importantes para a compreensão desses processos, auxilia na interpretação de dados complexos para melhorar o monitoramento e uso das informações para os tomadores de decisão.

ABSTRACT Spatial and temporal variability patterns of water quality were evaluated through monthly collection of water samples (surface, sub-surface and bottom) from 2005 to 2012. Principal Component Analysis was used to define the relative importance of each variable and Anova (two way) to analyze the significance of differences in water quality in the longitudinal axis of the reservoir. The variables: turbidity, Secchi transparency, residence time and temperature have greater importance on water quality. It was observed spatial and temporal gradients, related to the circulation, sedimentation and resuspension processes, and the influence of low flow, high residence time and winter mixing of water column on the cycling of solids and nutrients may explain the variation in these processes. The use of multivariate statistical analysis methods provided important information to understand these processes, it helps the interpretation of complex data to improve monitoring, and use of information to decision makers.

https://doi.org/10.1590/2318-0331.272220210126

13.

Recommendations by the Scientific Department of Neuroimmunology of the Brazilian Academy of Neurology (DCNI/ABN) and the Brazilian Committee for Treatment and Research in Multiple Sclerosis and Neuroimmunological Diseases (BCTRIMS) on vaccination in general and specifically against SARS-CoV-2 for patients with demyelinating diseases of the central nervous system
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Becker, Jefferson

; Ferreira, Lis Campos

; Damasceno, Alfredo

; Bichuetti, Denis Bernardi

; Christo, Paulo Pereira

; Callegaro, Dagoberto

; Peixoto, Marco Aurélio Lana

; Sousa, Nise Alessandra De Carvalho

; Almeida, Sérgio Monteiro De

; Adoni, Tarso

; Santiago-Amaral, Juliana

; Junqueira, Thiago

; Pereira, Samira Luisa Apóstolos

; Gomes, Ana Beatriz Ayroza Galvão Ribeiro

; Pitombeira, Milena

; Paolilo, Renata Barbosa

; Grzesiuk, Anderson Kuntz

; Piccolo, Ana Claudia

; D´Almeida, José Arthur Costa

; Gomes Neto, Antonio Pereira

; Oliveira, Augusto Cesar Penalva De

; Oliveira, Bianca Santos De

; Tauil, Carlos Bernardo

; Vasconcelos, Claudia Ferreira

; Kaimen-Maciel, Damacio

; Varela, Daniel

; Diniz, Denise Sisterolli

; Oliveira, Enedina Maria Lobato De

; Malfetano, Fabiola Rachid

; Borges, Fernando Elias

; Figueira, Fernando Faria Andrade

; Gondim, Francisco De Assis Aquino

; Passos, Giordani Rodrigues Dos

; Silva, Guilherme Diogo

; Olival, Guilherme Sciascia Do

; Santos, Gutemberg Augusto Cruz Dos

; Ruocco, Heloisa Helena

; Sato, Henry Koiti

; Soares Neto, Herval Ribeiro

; Cortoni Calia, Leandro

; Gonçalves, Marcus Vinícius Magno

; Vecino, Maria Cecilia Aragón De

; Pimentel, Maria Lucia Vellutini

; Ribeiro, Marlise De Castro

; Boaventura, Mateus

; Parolin, Mônica Koncke Fiuza

; Melo, Renata Brant De Souza

; Lázaro, Robson

; Thomaz, Rodrigo Barbosa

; Kleinpaul, Rodrigo

; Dias, Ronaldo Maciel

; Gomes, Sidney

; Lucatto, Simone Abrante

; Alves-Leon, Soniza Vieira

; Fukuda, Thiago

; Ribeiro, Taysa Alexandrino Gonsalves Jubé

; Winckler, Thereza Cristina D’ávila

; Fragoso, Yara Dadalti

; Nascimento, Osvaldo José Moreira Do

; Ferreira, Maria Lucia Brito

; Mendes, Maria Fernanda

; Brum, Doralina Guimarães

; Glehn, Felipe Von

Arquivos de Neuro-Psiquiatria

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nov 2021, Volume 79 N. 11 Pages 1049 - 1061

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO O DC de Neuroimunologia da ABN e o BCTRIMS trazem, nesse documento, as recomendações sobre vacinação da população com doenças desmielinizantes do sistema nervoso central (SNC) contra infecções em geral e contra o coronavírus da síndrome respiratória aguda grave 2 (SARS-CoV-2), causador da COVID-19. Destaca-se a gravidade do atual momento frente ao avanço da COVID-19 em nosso País, o que torna mais evidente e importante a criação de guia de referência para orientação aos médicos, pacientes e autoridades de saúde pública quanto à vacinação, meio efetivo e seguro no controle de determinadas doenças infecciosa. O DCNI/ABN e o BCTRIMS recomendam que os pacientes com doenças desmielinizantes do SNC (ex., EM e NMOSD) sejam constantemente monitorados, quanto a atualização do seu calendário vacinal, especialmente, no início ou antes da mudança do tratamento com uma droga modificadora de doença (DMD). É importante também salientar que as vacinas são seguras e os médicos devem estimular o seu uso em todos os pacientes. Evidentemente, deve ser dada especial atenção às vacinas com vírus vivos atenuados. Por fim, é importante que os médicos verifiquem qual DMD o paciente está em uso e quando foi feita a sua última dose, pois cada fármaco pode interagir de forma diferente com a indução da resposta imune.

ABSTRACT The Scientific Department of Neuroimmunology of the Brazilian Academy of Neurology (DCNI/ABN) and Brazilian Committee for Treatment and Research in Multiple Sclerosis and Neuroimmunological Diseases (BCTRIMS) provide recommendations in this document for vaccination of the population with demyelinating diseases of the central nervous system (CNS) against infections in general and against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes COVID-19. We emphasize the seriousness of the current situation in view of the spread of COVID-19 in our country. Therefore, reference guides on vaccination for clinicians, patients, and public health authorities are particularly important to prevent some infectious diseases. The DCNI/ABN and BCTRIMS recommend that patients with CNS demyelinating diseases (e.g., MS and NMOSD) be continually monitored for updates to their vaccination schedule, especially at the beginning or before a change in treatment with a disease modifying drug (DMD). It is also important to note that vaccines are safe, and physicians should encourage their use in all patients. Clearly, special care should be taken when live attenuated viruses are involved. Finally, it is important for physicians to verify which DMD the patient is receiving and when the last dose was taken, as each drug may affect the induction of immune response differently.

https://doi.org/10.1590/0004-282x-anp-2021-0162 1 downloads

14.

The structure of qualitative studies: a bibliometric pattern of biomedical literature
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Bastos, Rodrigo Almeida

; Alves, Vera Lucia Pereira

; Sena, Rômulo Magnus de Castro

; Jesus, Juliana Vasconcellos Freitas de

; Rodrigues, Larissa

; Surita, Fernanda Garanhani de Castro

; Turato, Egberto Ribeiro

Ciência & Saúde Coletiva

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aug 2021, Volume 26 N. 8 Pages 3199 - 3208

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo A dificuldade de entendimento na literatura biomédica sobre a validade dos estudos qualitativos pode estar relacionada ao menor número de estudos qualitativos publicados. As críticas também vão desde a falta de profundidade teórica até discussões pouco objetivas de descobertas empíricas. O objetivo deste estudo foi explorar padrões bibliométricos e as tendências na estrutura das pesquisas qualitativas na literatura biomédica. Utilizou-se análise bibliométrica e mapeamento da literatura biomédica. O número de estudos selecionados foi 1.725. Os temas de saúde com mais publicações incluíram Gestão em Saúde (12%) e Saúde da Mulher (9,8%), enquanto os autores dos estudos tiveram afiliação acadêmica em 76 países diferentes. O tamanho da amostra mais observado foi de 11 a 20 participantes (27,13%) e o referencial da Grounded Theory (9,04%) o mais utilizado. A estruturação aprimorada de uma pesquisa qualitativa amplia a comunicação eficaz entre profissionais de saúde e pesquisadores, além de apoiar o gerenciamento de situações clínicas.

Abstract The lack of knowledge in the biomedical literature regarding the validity of qualitative studies might be related to the lower number of qualitative studies that have been published. The criticisms range from a lack of theoretical depth to the superficial discussions of empirical findings. The aim of this study was to explore the bibliometric entities and the trends in the structure of qualitative research in the biomedical literature. A bibliometric analysis and mapping of the biomedical literature were used. The number of studies selected was 1,725. The heath themes with the most publications included Health Management (12%) and Women’s Health (9.8%), while the authors of the studies had academic affiliation in 76 different countries. The sample sizes were between 11 and 20 participants (27.13%) and the Grounded Theory framework (9.04%) stood out. The improved structuring of a qualitative research extends the effective communication between health providers and researchers, and support in the management of clinical situations.

https://doi.org/10.1590/1413-81232021268.12922020 3 downloads

15.

Adipose tissue-derived stromal/stem cells + cholecalciferol: a pilot study in recent-onset type 1 diabetes patients
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Dantas, Joana Rodrigues

; Araújo, Débora Batista

; Silva, Karina Ribeiro

; Souto, Débora Lopes

; Pereira, Maria de Fátima Carvalho

; Luiz, Ronir Raggio

; Mantuano, Matheus dos Santos

; Claudio-da-Silva, Cesar

; Gabbay, Monica Andrade Lima

; Dib, Sérgio Atala

; Couri, Carlos Eduardo Barra

; Maiolino, Angelo

; Rebelatto, Carmen Lúcia Kuniyoshi

; Daga, Débora Regina

; Senegaglia, Alexandra Cristina

; Brofman, Paulo Roberto Slud

; Baptista, Leandra S.

; Oliveira, José Egídio Paulo de

; Zajdenverg, Lenita

; Rodacki, Melanie

Archives of Endocrinology and Metabolism

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jun 2021, Volume 65 N. 3 Pages 342 - 351

Abstract: En | Text: En | PDF: En

ABSTRACT Objective: Adipose tissue-derived stromal/stem cells (ASCs) and vitamin D have immunomodulatory actions that could be useful for type 1 diabetes (T1D). We aimed in this study to investigate the safety and efficacy of ASCs + daily cholecalciferol (VIT D) for 6 months in patients with recent-onset T1D. Materials and methods: In this prospective, dual-center, open trial, patients with recent onset T1D received one dose of allogenic ASC (1 x 106 cells/kg) and cholecalciferol 2,000 UI/day for 6 months (group 1). They were compared to patients who received chol-ecalciferol (group 2) and standard treatment (group 3). Adverse events were recorded; C-peptide (CP), insulin dose and HbA1c were measured at baseline (T0), after 3 (T3) and 6 months (T6). Results: In group 1 (n = 7), adverse events included transient headache (all), mild local reactions (all), tachycardia (n = 4), abdominal cramps (n = 1), thrombophlebitis (n = 4), scotomas (n = 2), and central retinal vein occlusion at T3 (n = 1, resolution at T6). Group 1 had an increase in basal CP (p = 0.018; mean: 40.41+/-40.79 %), without changes in stimulated CP after mixed meal (p = 0.62), from T0 to T6. Basal CP remained stable in groups 2 and 3 (p = 0.58 and p = 0.116, respectively). Group 1 had small insulin requirements (0.31+/- 0.26 UI/kg) without changes at T6 (p = 0.44) and HbA1c decline (p = 0.01). At T6, all patients (100%; n = 7) in group 1 were in honeymoon vs 75% (n = 3/4) and 50% (n = 3/6) in groups 2 and 3, p = 0.01. Conclusions: Allogenic ASC + VIT D without immunosuppression was safe and might have a role in the preservation of β-cells in patients with recent-onset T1D. ClinicalTrials.gov: NCT03920397.

https://doi.org/10.20945/2359-3997000000368 236 downloads

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