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In this study, we aimed to investigate the anticancer activity of the extract, fractions, and isolated compounds of the flowers of Fridericia platyphylla, and to characterize the bioactive compounds. The chemical diversity of the extracts and fractions was investigated using liquid chromatography coupled with high resolution mass spectrometry (LC-HRMS). We were able to annotate 26 compounds from the classes of flavones, flavonols, flavanones, isoflavones, and cinnamic acid and its derivatives. The dichloromethane fraction showed greater cytotoxicity at a concentration of 100 µg mL−1. In addition, the inhibitory concentrations of the dichloromethane fraction were 22.14 and 30.9 µg mL−1 for MCF-7 and MDA-MB-231 cell lines, respectively, and were capable of inhibiting tumor cell migration. Brachydins A and C were isolated from the dichloromethane fraction and showed the greatest cytotoxicity. The results obtained from this study show the potential biological effect of F. platyphylla flowers as a possible antitumor pharmacological agent. extract LCHRMS. LCHRMS LC HRMS . (LC-HRMS) 2 flavones flavonols flavanones isoflavones derivatives 10 mL1 mL 1 addition 2214 22 14 22.1 309 30 9 30. mL− MCF7 MCF 7 MCF- MDAMB231 MDAMB MDA MB 231 MDA-MB-23 lines respectively migration F agent (LC-HRMS 221 22. 3 MDAMB23 23 MDA-MB-2 MDAMB2 MDA-MB- MDA-MB

https://doi.org/10.21577/0103-5053.20240132

Instructional videos for parents/guardians of children with lip and palate clefts: integrative literature review parentsguardians parents guardians clefts
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Mendes, Débora Letícia Moreira

; Andrade, Lucas Gabriel Nunes

; Joaquim, Davide Carlos

; Benedito, Francisco Cezanildo Silva

; Leite, Ana Caroline Rocha de Melo

; Girão-Carmona, Virgínia Cláudia Carneiro

Jornal de Pediatria

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oct 2024, Volume 100 N. 5 Pages 468 - 475

Abstract: En | Text: En | PDF: En

Abstract Objective This study aimed to review literature from the past five years, focusing on the use of educational videos as a guidance tool for parents and guardians of children with lip and palate clefts. Source of data Conducted between April and July 2022, this integrative literature review was framed around the question: 'What is the evidence regarding the use of videos in health education for parents/guardians of children with cleft lip and palate? PICO strategy was used to develop the research. A literature search was undertaken across PubMed, Web of Science, Scopus, and the Virtual Health Library databases. Of the eight articles included in this review, four were sourced from the PubMed database, with three published in 2021. Summary of the findings The findings indicated that YouTube videos were moderately satisfactory and met the needs of parents or legal guardians to a partial extent. The majority of the videos analyzed in this review were characterized by a moderate level of informational content. One study particularly underscored that the content of these videos only partially satisfies the requirements of the parents or legal guardians of the children. Conclusions Nevertheless, such videos are considered viable alternatives for health education, offering numerous benefits yet facing challenges, primarily due to the scarcity of information on orofacial malformations. years clefts 2022 question What parentsguardians research Science Scopus databases database 2021 extent Nevertheless challenges malformations 202 20 2

https://doi.org/10.1016/j.jped.2024.02.004

Estudio de la enseñanza de habilidades asociadas al diseño de ingeniería y a la comunicación en un aula universitaria. Una mirada desde el análisis del discurso
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Iturralde, María Cristina

; Rocha, Adriana

; Falicoff, Claudia

Revista de enseñanza de la física

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jun 2024, Volume 36 N. 1 Pages 141 - 142

Abstract: Es | Text: Es | PDF: Es

Resumen En Argentina se instaló hace varios años respecto a la formación en ingeniería, la necesidad de incorporar enfoques de enseñanza que atiendan al desarrollo de competencias. Y en ese contexto, se acuerda que el estudiante debe formarse de manera integral en aspectos relacionados con el saber, el saber hacer y el saber ser. En concordancia con ello se promueve una idea de enseñanza centrada en el estudiante, en la cual el rol del docente es el de facilitador de los aprendizajes. Esta nueva mirada de la formación en ingeniería ha generado en las instituciones formadoras la discusión acerca de qué contenidos enseñar, cómo enseñarlos, qué estrategias de enseñanza son adecuadas para que los estudiantes desarrollen competencias. Teniendo en cuenta estas discusiones y los cambios que se reclaman a la formación universitaria, se llevó adelante el trabajo de tesis cuyo resumen aquí se presenta. La investigación se focalizó en una asignatura de 4° año de la carrera de Ingeniería Electromecánica de la Facultad de Ingeniería de la Universidad Nacional del Centro de la Provincia de Buenos Aires. Se identificaron dos competencias que resultan centrales y sobre las que la asignatura procura hacer aportes significativos: la competencia para concebir, diseñar y desarrollar proyectos de ingeniería y la competencia para comunicarse con efectividad. A partir de ello se identificaron los respectivos contenidos procedimentales (modelización y comunicación escrita) asociados cada uno, al desarrollo de una de las competencias mencionadas. Se analizó la enseñanza atendiendo a identificar cómo las actividades que se proponen desarrollar en las clases, se constituyen en oportunidades de aprendizaje para los estudiantes. Dicho análisis se centró en la comunicación que establece el profesor con los estudiantes, y permitió indagar cómo se aborda la enseñanza de los contenidos procedimentales mencionados. Por una parte, se identificaron las principales prácticas de modelización que se potenciaron y las estrategias discursivas que podrían considerarse favorecedoras del aprendizaje de la modelización. Se analizó el uso de recursos extralingüísticos y de signos en el discurso docente, como facilitadores de la comprensión de los estudiantes. En cuanto a la enseñanza de la comunicación escrita se concluyó que se estarían potenciando aprendizajes sobre el género discursivo “redacción de informes” y sobre los aspectos formales de la escritura; sin tomar en cuenta el aporte al desarrollo de procesos cognitivos relacionados con el aprendizaje de la modelización. Por otra parte, se puso en evidencia la potencialidad de la metodología de investigación empleada para el estudio de situaciones educativas en contextos reales, como lo son los procesos de enseñanza en un aula universitaria. Y por último se destaca que este tipo de trabajo de investigación tiene un importante impacto en la formación de los docentes y de los investigadores involucrados. En particular, las conclusiones a que se arriba son insumos para la reflexión docente sobre las prácticas de enseñanza en la universidad.

Consenso mexicano de cáncer mamario. Manejo del cáncer de mama avanzado
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Cervantes-Sánchez, Guadalupe

; Hernández-Barragán, Tania

; Aldaco, Fernando

; Arce-Salinas, Claudia

; Bargalló-Rocha, Juan E.

; Bautista-Piña, Verónica

; Chávez-MacGregor, Mariana

; Garnica-Jaliffe, Georgina

; Flores-Balcázar, Christian H.

; Lara-Tamburrino, Ma. del Carmen

; Lluch-Hernández, Ana

; Maffuz-Aziz, Antonio

; Pérez, Perla

; Pérez-Sánchez, Víctor M.

; Poitevín-Chacón, Adela

; Salas-González, Efraín

; Soto-Pérez-de Celis, Enrique

; Torrecillas-Torres, Laura

; Valero-Castillo, Vicente

; Villaseñor-Navarro, Yolanda

; Cárdenas-Sánchez, Jesús

Gaceta mexicana de oncología

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jun 2024, Volume 23 N. 2 Pages 92 - 106

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

Resumen El cáncer de mama es la neoplasia más frecuente y con mayor mortalidad en mujeres en todo el mundo. La décima actualización del Consenso Mexicano Sobre Diagnóstico y Tratamiento del Cáncer Mamario (2023) es publicada por sus autores en diferentes artículos. El presente artículo incluye el manejo de cáncer de mama avanzado, el tratamiento sistémico adyuvante, el papel de la cirugía y la radioterapia en enfermedad metastásica y el seguimiento posterior al tratamiento con intención curativa. La difusión de este consenso contribuye a la actualización y homogeneidad de criterios de manejo del cáncer mamario en etapas avanzadas.

Abstract Breast cancer is the most common neoplasia, with the highest mortality in women worldwide. The tenth update of the Me-xican Consensus on Diagnosis and Treatment of Breast Cancer (2023) is published by its authors in different articles. This article includes the management of advanced breast cancer, the adjuvant systemic treatment, the role of surgery and radiotherapy in metastatic disease, and follow-up after treatment with curative intent. The dissemination of this consensus contri-butes to the updating and homogeneity of breast cancer management of advanced stages.

https://doi.org/10.24875/j.gamo.m23000258

JOÃO BATISTA LIBANIO: UM DISCÍPULO AMADO LIBANIO
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Oliveira, Claudia Maria Rocha de

Perspectiva Teológica

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apr 2024, Volume 56 N. 1 Pages 111 - 125

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Neste artigo pretendemos investigar a influência de Henrique Cláudio de Lima Vaz no percurso intelectual de João Batista Libanio. Para isso assumiremos como ponto de partida o texto “Lições do Mestre”, escrito por Libanio. Também examinaremos o artigo “Cristianismo e pensamento Utópico” e a resenha sobre a obra “Teologia da Libertação: roteiros didáticos para um estudo”, ambos escritos por Lima Vaz. Trata-se de investigar de que modo a influência de Lima Vaz marcou o modo de fazer teologia próprio de Libanio. Libanio Lições Mestre, Mestre , Mestre” Cristianismo Utópico Teologia Libertação estudo, estudo estudo” Tratase Trata se

ABSTRACT In this article we intend to investigate the influence of Henrique Cláudio de Lima Vaz on the intellectual route of João Batista Libanio. For this, we took as a starting point the text “Lições do Mestre”, written by Libanio. We will also examine the article “Cristianismo e pensamento utópico” and the review of the book Teologia da Libertação: roteiro didático para um estudo, both written by Lima Vaz. The aim is to investigate how Lima Vaz’s influence marked Libano’s own way of doing theology. Libanio Lições Mestre, Mestre , Mestre” Cristianismo utópico Libertação estudo Vazs s Libanos Libano theology

https://doi.org/10.20911/21768757v56n1p111/2024

Consenso mexicano de cáncer mamario. Manejo del cáncer de mama temprano
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Bargalló-Rocha, Juan E.

; Aguilar-Villanueva, Sergio

; Ahumada-Pámanes, Carolina

; Arce-Salinas, Claudia

; Álvarez-Cano, Alethia

; Baley-Spindel, Isaac

; Bautista-Piña, Verónica

; Cervantes-Sánchez, Guadalupe

; Chávez-MacGregor, Mariana

; Esparza-Arias, Nereida

; Figueroa-Padilla, Jonathán

; Flores-Balcázar, Christian H.

; Flores-Moreno, Sonia Ma.

; Maffuz-Aziz, Antonio

; Maldonado-Magos, Federico

; Lara-Tamburrino, Ma. del Carmen

; Lluch-Hernández, Ana

; Navarro-Santiesteban, Sarina

; Pérez-Sánchez, Víctor M.

; Poitevín-Chacón, Adela

; Ruvalcaba-Limón, Eva

; Salas-González, Efraín

; Sarricolea-Puch, Amelia

; Soto-Pérez-de-Celis, Enrique

; Torrecillas-Torres, Laura

; Valero-Castillo, Vicente

; Villaseñor-Navarro, Yolanda

; Chávarri-Guerra, Yanin

; Cárdenas-Sánchez, Jesús

Gaceta mexicana de oncología

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mar 2024, Volume 23 N. 1 Pages 30 - 61

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Abstract Breast cancer, in early stages, has specific surgical, radiotherapy, and systemic management. This type of cancer includes ductal carcinoma in situ and breast cancers in stages I, IIA, IIB, and IIIA. This tenth update of the Mexican Breast Cancer Consensus addressed the management of early stages. The dissemination of this consensus contributes to the updating and homogeneity of breast cancer management criteria. This article aims to present the update in the multidisciplinary management of breast cancer.

Resumen El cáncer mamario en estadios tempranos tiene un manejo local (quirúrgico y radioterapia) y sistémico específico. Este tipo de cáncer incluye el carcinoma ductal in situ y los cánceres de mama en estadios I, IIA, IIB y IIIA. Esta décima actualización del Consenso Mexicano de Cáncer Mamario abordó el manejo de los estadios tempranos. La difusión de este consenso contribuye a la actualización y homogeneidad de criterios de manejo del cáncer mamario y el objetivo de este artículo es presentar la actualización en el manejo multidisciplinario del cáncer de mama.

https://doi.org/10.24875/j.gamo.m24000261

[SciELO Preprints] - Critical Language Education for Radical Social Transformation: Discussions about Literacies, Criticality and Affect in Barbaric Times
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Rogério, Tilio Rocha, Claudia Hilsdorf

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Publication date: 2024-01-29

Abstract: En Pt

This article discusses the idea of critical linguistic education aiming at a radical social transformation – considering that this will only occur if critical and affective practices are integrated to the learning process. To achieve this objetive, we revisit the concept of critical literacy and then reflect on its connection with affectivity. After a brief review of the concept of criticality and its pedagogical appropriation by the theoretical strands named critical thinking, critical pedagogy, and critical literacy, we align ourselves with the perspective of criticality as a problematizing practice, which emerges from an engagement with differences. In chaotic times, we argue in favor of a linguistic education based on a critical-affective posture, so that the educational process follows the freirean philosophy, that is, is supportive of a transformative and peace-oriented education. Finally, we present a brief rereading of the pedagogy of multiliteracies, to instigate possibilities of pedagogical implementations that may contribute to an actual radical social transformation.

Nossa proposta, neste artigo, é discutir a ideia de educação linguística crítica com vistas a uma transformação social radical, entendendo que esta só ocorre se conduzida de forma crítica e afetiva. Para isso, revisitamos o conceito de letramento crítico, buscando refletir sobre sua ligação com a afetividade. Após uma breve revisão do conceito de criticidade e de sua apropriação pedagógica pelas vertentes denominadas pensamento crítico, pedagogia crítica e letramento crítico, alinhamo-nos com uma perspectiva de criticidade como prática problematizadora a partir do engajamento com as diferenças. Argumentamos em favor de uma educação linguística pautada em uma postura crítico-afetiva, em tempos caóticos, a fim de que o processo educativo possa realizar-se de modo alinhado à filosofia freireana e, assim, revelar-se transformador e orientado para a paz. Por fim, apresentamos uma breve releitura da chamada pedagogia dos multiletramentos, com o intuito de fomentar possibilidades de encaminhamentos pedagógicos que contribuam, de fato, para a transformação social radical.

https://doi.org/10.1590/1678-460x202457244

SciELO 25 years: The Scientific Electronic Library Online celebrates its 25th anniversary 2 years th
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Rocha, Eduardo M.

; Osaki, Tammy H.

; Kara Junior, Newton-

; Alves, Monica

; Moral, Claudia

Arquivos Brasileiros de Oftalmologia

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2024, Volume 87 N. 1 elocation e2024-1007

Abstract: En | Text: En | PDF: En

https://doi.org/10.5935/0004-2749.2024-1007

Consultas tardías en los servicios de emergencias pediátricas durante la pandemia por COVID-19 en Uruguay, entre el 13 de marzo y el 29 de julio de 2020
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Noya, Noelia

; Dávila, Manuel

; Osta, Lody

; Más, Mariana

; Tórtora, Soledad

; Amarillo, Paloma

; Dall´Orso, Patricia

; Prego, Javier

; Giacoia, Andreína

; Lemos, Isis

; Rodríguez, Luciana

; García, Lucila

; Ré, Marianela

; Gamino, Paula

; Meneses, Gabriel

; Lafón, Gabriela

; Castellanos, Florencia

; García, Virginia

; Siniestro, Jimena

; Venturino, Sergio

; Canziani, Catalina

; Pérez, Mariana

; Da Silva, Esteban

; Invernizzi, Marcelo

; Falcao, Gimena

; García, Emilia

; Steinfeld, Pablo

; Páez, Marcos

; Guzzetti, Valentina

; Venturino, Claudia

; Gibara, Silvia

; Urgoiti, Mariana

; Gnesetti, Anella

; Costa, Nadia

; Rocha, Sebastián

; Menta, Soledad

; Alsina, Susana

; Cabrera, Ana

; Zugarramurdi, Virginia

; Olivera, Valentina

; Henderson, Karem

Archivos de Pediatría del Uruguay

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2024, Volume 95 N. 1 elocation e202

Abstract: Es En Pt | Text: Es En Pt | PDF: Es | PDF: En | PDF: Pt

Resumen: En diciembre de 2019, en Wuhan, China, se detectaron los primeros casos de SARS-CoV-2. En Uruguay, desde el 16 de marzo de 2020 se suspendieron las actividades de enseñanza, deportivas y espectáculos públicos. Varios países reportaron una marcada disminución de las visitas a urgencias. Algunos niños presentaron enfermedades ocasionales o descompensaciones de enfermedades crónicas, consultando en forma tardía con el riesgo que ello implica. El objetivo de este trabajo es realizar una descripción de las consultas tardías durante la pandemia. Se realizó un estudio multicéntrico y descriptivo entre el 13 de marzo y el 29 de julio de 2020. Se definió consulta tardía como los ingresos por injurias agudas con más de 6 horas de evolución, fiebre mayor a 72 horas de evolución, dificultad respiratoria con más de 12 horas de evolución, síntomas agudos, como dolor abdominal, de más de 24 horas de evolución, síntomas de más de 12 horas de evolución en niños con enfermedades crónicas que determinaron descompensación e ingreso. Se incluyeron 27 centros. Se registraron un total de 34.260 consultas en urgencia, se incluyeron 189 niños para el estudio. El promedio de edad fue de 6 años; 17 pacientes requirieron ingreso a unidad de cuidados intensivos (UCI). Predominó la apendicitis entre los diagnósticos al alta. Esta investigación puso en evidencia la existencia de consultas tardías en nuestro país. Esto contribuye a ponderar el impacto negativo de la pandemia en la población pediátrica.

Summary: In December 2019, the first cases of SARS-CoV-2 were detected in Wuhan. In Uruguay, since March 16, teaching, sports and public entertainment activities were suspended. Several countries reported a marked decrease in emergency room visits. Some children presented occasional illnesses or decompensations from chronic illnesses, consulting late with the risk that this implies. The objective of the work is to make a description of late consultations during the pandemic. A multicenter and descriptive study was carried out between March 13 and July 29, 2020. “Late consultation” was defined as admissions for: Acute injuries with more than 6 hours of evolution, fever greater than 72 hours of evolution, difficulty respiratory disease with more than 12 hours of evolution, acute symptoms such as abdominal pain of more than 24 hours of evolution, symptoms of more than 12 hours of evolution in children with chronic diseases that determined decompensation and admission. 27 centers were included. A total of 34260 emergency consultations were registered, 189 children were included for the study. The average age was 6 years. 17 patients required admission to the ICU. Appendicitis predominated among the diagnoses at discharge. This research revealed the existence of late consultations in our country. This helps to weigh the negative impact of the pandemic on the pediatric population.

Resumo: Em dezembro de 2019, em Wuhan, foram detectados os primeiros casos de SARS-CoV-2. No Uruguai, desde 16 de março, as atividades de ensino, esporte e entretenimento público foram suspensas. Vários países relataram uma diminuição acentuada nas visitas ao pronto-socorro. Algumas crianças apresentavam doenças ocasionais ou descompensações de doenças crônicas, consultando tardiamente os riscos que isso implica. O objetivo do trabalho é fazer uma descrição das consultas tardias durante a pandemia. Um estudo multicêntrico e descritivo foi realizado entre 13 de março e 29 de julho de 2020. Consulta tardia foi definida como internações por: Lesões agudas com mais de 6 horas de evolução, febre maior que 72 horas de evolução, dificuldade respiratória com mais de 12 horas de evolução, sintomas agudos como dor abdominal com mais de 24 horas de evolução, sintomas com mais de 12 horas de evolução em crianças com doenças crônicas que determinaram descompensação e internação. 26 centros foram incluídos. Um total de 34.260 consultas de emergência foram registradas, 189 crianças foram incluídas no estudo. A idade média era de 6 anos. 17 pacientes necessitaram de internação na UTI. Apendicite predominou entre os diagnósticos na alta. Esta pesquisa revelou a existência de consultas tardias em nosso país. Isso ajuda a pesar o impacto negativo da pandemia na população pediátrica.

https://doi.org/10.31134/ap.95.1.2

10.

Grupo Científico Estudiantil Tecnología y Ciencia. Experiencias en la divulgación científica
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Alcaide Guardado, Yuleydi

; Rocha Vázquez, Mabel

; Jiménez-Franco, Luis Enrique

; Díaz de la Rosa, Claudia

; Acosta Figueredo, Enrique

; Vidal Martí, Juan Luis

Revista Información Científica

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2024, Volume 103 elocation e4575

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

RESUMO Introdução: A divulgação científica não deve ser vista apenas como uma atividade do profissional de comunicação ou jornalismo. Saber divulgar pesquisas científicas é uma forma de gestão do conhecimento adquirido. Objetivo: Descrever as experiências de divulgação científica do Grupo Científico de Estudantes de Tecnologia e Ciências. Método: Foi realizado estudo observacional, descritivo e transversal. Durante o período de outubro de 2020 a maio de 2023 na Universidad de Cieências Médicas de Cienfuegos, Cuba. As informaçõ es foram compiladas a partir da análise das evidências de trabalho do Grupo Científico Estudantil. As experiências foram descritas levando em consideração as ações, atividades e espaços criados para o desenvolvimento da divulgação científica. Resultados: O Grupo Científico Estudantil é composto por 14 estudantes de diferentes carreiras das ciências médicas. Destes: 7 são estudantes de Medicina, 2 pertencem à Estomatologia, 3 às Tecnologias da Saúde e 2 à carreira de Enfermagem. Quanto ao sexo, 57% são homens e 43% mulheres. O trabalho sistemático com o Grupo Científico de Estudantes tempermitido avanços consideráveis em termos de organização e desenvolvimento de eventos onde os resultados científicos são socializados e divulgados, além disso a sustentabilidade do trabalho emequipe tem permitido que as contribuições derivadas dos estudos sejam publicadas em revistas científicas. Conclusões: A atuação do Grupo Científico de Estudantes de Tecnologia e Ciências desempenha um papel decisivo na comunidade universitária, pois organiza atividades científicas e acadêmicas com o objetivo de aumentar o desenvolvimento científico dos estudantes.

ABSTRACT Introduction: Scientific dissemination should not be seen only as an activity of the communication or journalism professional. Knowing how to disseminate scientific research is a form of management of acquired knowledge. Objective: To describe the experiences in scientific dissemination of the Student Scientific Group: Technology and Science. Method: An observational, descriptive and cross-sectional study was carried out. During the period from October 2020 to May 2023 at the University of Medical Sciences of Cienfuegos, Cuba. The information was compiled from the analysis of the GCE's work evidence. The experiences were described taking into account the actions, activities and spaces created for the development of scientific dissemination. Results: The GCE is madeup of 14 students from different careers in medical sciences. Of them: seven are medical students, two belong to Stomatology, three to Health Technologies, and two to the Nursing career. Regarding sex, 57% are male and 43% female. The systematic work with the GCE has allowed for considerable progress in terms of organization and development of events where scientific results are socialized and disseminated, and the sustainability of team work has allowed the contributions derived from the results to be published in scientific journals. Conclusions: The work of the GCE: Technology and Science plays a decisive role in the university community, as it organizes scientific and academic activities in order to increase student scientific development.

RESUMEN Introducción: La divulgación científica no debe verse solo como una actividad propia del profesional de la comunicación o del periodismo. Saber divulgar una investigación científica es una forma de gestión del conocimiento adquirido. Objetivo: Describir las experiencias en la divulgación científica del Grupo Científico Estudiantil Tecnología y Ciencia. Método: Se realizó un estudio observacional, descriptivo y transversal. Durante el período comprendido de octubre de 2020 a mayo de 2023 en la Universidad de Ciencias Médicas de Cienfuegos, Cuba. La información se recopiló a partir del análisis de las evidencias de trabajo del Grupo Científico Estudiantil. Las experiencias se describieron teniendo en cuenta las acciones, actividades y espacios creados para el desarrollo de la divulgación científica. Resultados: El Grupo Científico Estudiantil está integrado por 14 estudiantes de las diferentes carreras de las ciencias médicas. De ellos: 7 son estudiantes de Medicina, 2 pertenecen a Estomatología, 3 a las Tecnologías de la Salud y 2 a la carrera de Enfermería. En cuanto al sexo el 57 % son masculinos y el 43 % femeninos. El trabajo sistemático con el Grupo Científico Estudiantil ha permitido avanzar considerablemente en cuanto a organización y desarrollo de eventos donde se socializan y divulgan resultados científicos, además la sostenibilidad del trabajo en equipo ha permitido que se publiquen en revistas científicas los aportes que se derivan de los resultados. Conclusiones: El trabajo del Grupo Científico Estudiantil Tecnología y Ciencia juega un papel decisivo en la comunidad universitaria, pues organiza actividades científicas y académicas en aras de incrementar el desarrollo científico estudiantil.

11.

Prevalence and clinical consequences of Hepatitis C virus infection in patients undergoing hematopoietic stem cell transplantation
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Diaz, Ana Claudia Marques Barbosa

; Witkin, Steven Sol

; Almeida Neto, Cesar de

; Mendrone Junior, Alfredo

; Rocha, Vanderson

; Costa, Silvia Figueiredo

; Ramos, Jessica Fernandes

; Mendes-Correa, Maria Cassia

Revista do Instituto de Medicina Tropical de São Paulo

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2024, Volume 66 elocation e11

Abstract: En | Text: En | PDF: En

ABSTRACT Hepatitis C virus (HCV) infection is a significant cause of morbidity and mortality among hematopoietic stem cell transplant (HCT) recipients. In Brazil, its occurrence in HCT recipients remains undetermined. We now report on HCV prevalence in HCT recipients and its clinical consequences. The medical records of all HCT recipients seen at Hospital das Clinicas, Sao Paulo University Medical School, from January 2010 to January 2020 were reviewed to determine HCV serostatus. A retrospective analysis of medical charts was undertaken on all seropositive cases to determine HCV genotype, presence of liver fibrosis, co-infections with other viruses, previous treatments, and clinical evolution of liver pathology after HCT. Of the 1,293 HCT recipients included in the study, seven (0.54%) were HCV antibody-positive and five (0.39%) were also viremic for HCV-RNA. Four of these individuals had moderate to severe liver fibrosis (METAVIR F2/F3) and one was cirrhotic. Two of the viremic patients developed acute liver dysfunction following transplantation. All patients had their acute episode of liver dysfunction resolved with no further complications. Four of the viremic patients were treated for HCV infection with direct acting agents (DAA). Information regarding HCV treatment was lacking for one of the viremic HCV patients due to loss of follow up. Sustained anti-virologic responses were observed in three cases after the use of DAA. The detection of HCV in hematological adults undergoing HCT and its successful treatment with DAA highlight the necessity of testing for HCV both prior to and following transplantation. (HCV (HCT Brazil undetermined consequences Clinicas School 201 202 serostatus genotype coinfections co infections viruses treatments 1293 1 293 1,29 study 0.54% 054 0 54 (0.54% antibodypositive antibody positive 0.39% 039 39 (0.39% HCVRNA. HCVRNA RNA. RNA HCV-RNA METAVIR F2/F3 F2F3 FF F2 F3 F cirrhotic transplantation complications . (DAA) up antivirologic anti virologic 20 129 29 1,2 0.54 05 5 (0.54 0.39 03 3 (0.39 F2/F F2F (DAA 2 12 1, 0.5 (0.5 0.3 (0.3 0. (0. (0 (

https://doi.org/10.1590/s1678-9946202466011

12.

GREEN SYNTHESIS OF FexOy STRUCTURES USING Euterpe oleracea MART EXTRACT FROM THE LEGAL AMAZON, BRAZIL AMAZON
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Borges, Simara F.

; Andrade, Karollyne S.

; Vaz, Evilly C.

; Morais Neto, Manoel D.

; Cabral, Aluisio A.

; V. Sobrinho, Eledir

; Rocha, Cláudia Q. da

; Figueredo, Gilvan P. de

Química Nova

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2024, Volume 47 N. 8 elocation e-20240034

Abstract: En | Text: En | PDF: En

The synthesis of oxides using plant extracts as precursors has attracted attention as it is an economical, efficient, and ecological route. Euterpe oleracea Mart, available in the Legal Amazon, has great potential due to its composition, rich secondary metabolites. Therefore, this work aimed to investigate the potential of aqueous açaí leaf extract as precursors in synthesizing FexOy-type oxides. The synthesis was developed in two stages to obtain the hematite phases (step 1) and the magnetite phase (step 2). The effect of pH on phase formation and structure was evaluated in step 1. Then, the material was obtained in step 2 by precipitation with pH adjustment. The powders were characterized by thermal analysis, X-ray diffraction, infrared spectroscopy, and scanning electron microscopy. The results showed that pH played a significant role in the thermal behavior, crystallite sizes, and structural parameters of hematite, with neutral or acidic pH being more attractive for obtaining crystallites between 21 and 24 nm. Magnetite with 21.51 nm crystallites was precipitated, indicating possible capping of the Fe3O4 particles and preserving their magnetic characteristics. economical efficient route Mart Amazon composition metabolites Therefore FexOytype FexOy type 1 2. . 2) Then adjustment analysis Xray X ray diffraction spectroscopy microscopy behavior sizes 2151 51 21.5 precipitated FeO Fe O Fe3O characteristics 215 5 21.

https://doi.org/10.21577/0100-4042.20240034

13.

Fish attractors when resources abound: prevalence of juveniles and lack of assemblage structure in a field experiment in the Amazon floodplain abound
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da Rocha, Silvia I.B.

; Pires, Tiago H.S.

; Amadio, Sidinéia A.

; Röpke, Cristhiana

; de Deus, Claudia P.

Biota Neotropica

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2024, Volume 24 N. 1 elocation e20231518

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo As estruturas flutuantes, naturais ou artificiais, atraem os peixes, fornecendo abrigo, áreas de alimentação e locais de nidificação. A ocupação pode ser mais permanente, resultando em um recolhimento gradativo da assembleia, ou transitória, ocorrendo aleatoriamente. A capacidade de um atrator de manter uma assembleia de peixes pode depender da disponibilidade de recursos de habitat no ambiente. Novos atratores artificiais são mais valiosos quando os naturais são escassos. Além disso, as características dos peixes desempenham um papel, já que peixes jovens e pequenos podem necessitar de novos habitats como abrigo mais do que peixes adultos. Como as áreas com herbáceas aquáticas são abundantes durante as cheias, coincidindo com o período de reprodução dos peixes, elas são especialmente relevantes para peixes juvenis. Construímos atratores de peixes compostos de material natural para investigar a estrutura das assembleias de peixes durante a cheia de um lago de várzea amazônico, a fim de testar a hipótese de que durante o período de cheia, os processos de montagem seriam aleatórios e com predominância de juvenis nos atratores. Os peixes foram coletados em intervalos de 5, 15 e 30 dias, resultando em 39 observações, e classificados como adultos ou juvenis. A composição de espécies foi comparada entre os tratamentos usando uma Análise de Coordenadas Principais (PCoA). O processo de montagem foi testado por meio de padrões de coocorrência de espécies usando modelos nulos e o índice C-score. A proporção de jovens e adultos foi comparada usando um teste Qui-quadrado. A composição de espécies permaneceu a mesma ao longo do experimento. A montagem da assembleia foi aleatória com prevalência de juvenis nos atratores, que possivelmente serviam apenas como abrigo temporário e áreas de alimentação. Nosso estudo contribui para entender o papel da disponibilidade de novos habitats para peixes de várzea durante a cheia. Os resultados sugerem que atratores flutuantes e novos habitats podem ser mais valiosos para os peixes jovens do que para adultos e podem ser usados como estratégia de manejo para a recuperação populacional, especialmente quando habitats de herbáceas flutuantes são escassos. nidificação permanente transitória aleatoriamente ambiente escassos disso cheias amazônico 5 1 3 dias observações PCoA. PCoA . (PCoA) Cscore. Cscore C score. score C-score Quiquadrado. Quiquadrado Qui quadrado. quadrado Qui-quadrado experimento populacional (PCoA

Abstract Floating structures, both natural and artificial, attract fish by providing shelter, feeding areas, and nesting sites. Occupancy can be either more permanent, leading to a gradual gathering of the assembly, or transient, occurring randomly. The ability of an attractor to hold a fish assemblage may depend on the availability of habitat resources in the environment. New artificial attractors are more valuable when natural ones are scarce. Additionally, fish characteristics play a role; young and small fishes may need new habitat for shelter more than adult fish. As aquatic herbaceous areas are abundant during high water, coinciding with the period of fish reproduction, they are particularly relevant for juveniles. We constructed fish attractors composed of natural materials to investigate the structure of fish assemblages during the flood of an Amazonian floodplain lake. Our aim was to test the hypothesis that assembly processes during the flood period would be random, with a predominance of juveniles in the attractors. We collected fish at intervals of 5, 15, and 30 days, resulting in 39 observations, and classified them as either adult or juvenile. Species composition was compared among treatments using Principal Coordinates Analysis (PCoA). The assembly process was tested through species co-occurrence patterns employing null models and the C-score index. The proportion of juveniles and adults was compared using a Chi-square test. Species composition remained consistent throughout the experiment. The assembly was random, with a prevalence of juveniles, possibly serving only as temporary shelter and feeding areas. Our study contributes to understanding the role of habitat availability for floodplain fishes during high waters. The results suggest that floating attractors and new habitats may be more valuable for the juveniles than adult fish and can be used as a management strategy for population recovery, especially when floating herbaceous habitats are scarce. structures sites permanent transient randomly environment scarce Additionally water reproduction lake random 5 15 3 days observations juvenile PCoA. PCoA . (PCoA) cooccurrence co occurrence Cscore C score index Chisquare Chi square experiment waters recovery 1 (PCoA

https://doi.org/10.1590/1676-0611-bn-2023-1518

14.

Chemical Characterization and Evaluation of the Antitumoral Activity of Annona tomentosa R.E.Fr. on Breast (MCF-7) Three-Dimensional (3D) Tumor Spheroids REFr R E Fr R.E.Fr MCF7 MCF 7 (MCF-7 ThreeDimensional Three Dimensional 3D D (3D (MCF- (MCF
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Pinheiro, Aglaete A.

; Lee, Celina Y.-A. L.

; Santos, Anna Gabriele P. dos

; Pereira, Érica R.

; Rosário, Marcelino S. do

; Ribeiro, Diego Luis

; Serpeloni, Juliana Mara

; Rocha, Cláudia Q. da

Journal of the Brazilian Chemical Society

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2024, Volume 35 N. 8 elocation e-20240037

Abstract: En | Text: En | PDF: En

Annona tomentosa, popularly known as “araticum marolo”, is an Annonaceae with little scientific evidence regarding its phytochemistry and biological activities. Based on this, the present study carried out the chemical characterization of the methanolic extract and fractions of ethyl acetate and alkaloid of the stem bark of A. tomentosa, in addition to evaluating their influence on the viability, proliferation and migration of breast (MCF-7) cells in a three-dimensional (3D) model. The samples were analyzed by liquid chromatography tandem mass spectrometry (LC MS/MS), and the Global Natural Products Social Networking (GNPS) platform was used to construct a molecular network. 21 compounds were identified, of which 16 belong to the alkaloid class. Multicellular spheroids (MCTS) growth was reduced after 216 h of treatment, as well as their viability (ca. 50% for the extract and ca. 25% for the alkaloid fraction). The extract and the alkaloid fraction showed greater antiproliferative (at a concentration of 100 µg mL-1 after 216 h, ca. 48% for the extract and ca. 20% for the fraction) and antimigratory (at concentrations 50-500 µg mL-1 for the extract and 100-250 µg mL-1 for the fraction) effects. This study is pioneering in demonstrating the antitumor effects in a 3D culture model, also revealing its potential for the isolation of alkaloids. tomentosa araticum marolo, marolo , marolo” activities this A MCF7 MCF 7 (MCF-7 threedimensional three dimensional D (3D model LC MS/MS, MSMS MS/MS MS MS/MS) GNPS (GNPS network 2 identified 1 class MCTS (MCTS treatment ca (ca 50 25 fraction. . at 10 mL1 mL mL- 48 20 50500 500 50-50 100250 250 100-25 alkaloids (MCF- 5 4 5050 50-5 10025 100-2 (MCF 505 50- 1002 100-

https://doi.org/10.21577/0103-5053.20240037

15.

Salivary immunoglobulin levels and periodontal indices in Brazilian children with and without type 1 diabetes
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RIBEIRO, Thyciana Rodrigues

; SILVA, Sara Maria

; MARTINS, Renata Asfor Rocha Carvalho

; SANTOS, Cláudia Ferreira

; SILVA, Paulo Goberlânio de Barros

; FORTI, Adriana Costa e

; COSTA, Fábio Wildson Gurgel

; FONTELES, Manassés Claudino

; FONTELES, Cristiane Sá Roriz

Brazilian Oral Research

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2024, Volume 38 elocation e043

Abstract: En | Text: En | PDF: En

Abstract This cross-sectional study evaluated the association between salivary immunoglobulins, plaque index, and gingival index in Brazilian children with and without type 1 diabetes mellitus (DM1). The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) checklist for the reporting of observational studies was followed. The DM1 group had 38 children, and an equal number of volunteers matched by sex and age were recruited as controls. Clinical examination was performed for plaque index and gingival index determination. Non-stimulated whole saliva was collected. Concentrations of IgA, IgG, and IgM were determined by ELISA test. Data were tested by the Kolmogorov-Smirnov, Mann-Whitney, and Spearman tests and a multiple linear regression model (p<0.05) was performed. Gingival index was higher in the Control (DM1: 0.16±0.17; Control: 0.24±0.23, p=0.040). In DM1, there was a correlation between IgA and age (rho=0.371, p=0.024), IgM and IgG (rho=0.459, p=0.007), and IgM and gingival index (rho=0.394, p=0.014). In DM1, multiple linear regression showed that age (p=0.041; β=0.363), gingival index (p=0.041; β=0.398), and plaque index (p=0.008; β=-0.506) were good predictors of IgA levels in saliva. Thus, IgA was the only researched immunoglobulin that was directly associated with plaque and gingival indices in Brazilian children with DM1, but not in control subjects. crosssectional cross sectional immunoglobulins DM1. DM . (DM1) STROBE (STROBE followed 3 controls determination Nonstimulated Non stimulated collected test KolmogorovSmirnov, KolmogorovSmirnov Kolmogorov Smirnov, Smirnov Kolmogorov-Smirnov MannWhitney, MannWhitney Mann Whitney, Whitney Mann-Whitney p<0.05 p005 p 0 05 (p<0.05 (DM1 0.16±0.17 016017 16 17 024023 24 23 0.24±0.23 p=0.040. p0040 p=0.040 040 p=0.040) rho=0.371, rho0371 rho 371 (rho=0.371 p=0.024, p0024 p=0.024 , 024 p=0.024) rho=0.459, rho0459 459 (rho=0.459 p=0.007, p0007 p=0.007 007 p=0.007) rho=0.394, rho0394 394 (rho=0.394 p=0.014. p0014 p=0.014 014 p=0.014) p=0.041 p0041 041 (p=0.041 β=0.363, β0363 β β=0.363 363 β=0.363) β=0.398, β0398 β=0.398 398 β=0.398) p=0.008 p0008 008 (p=0.008 β=0.506 β0506 β= 0.506 506 β=-0.506 Thus subjects p<0.0 p00 (p<0.0 (DM 0.16±0.1 01601 02402 2 0.24±0.2 p004 p=0.04 04 rho=0.371 rho037 37 (rho=0.37 p002 p=0.02 02 rho=0.459 rho045 45 (rho=0.45 p000 p=0.00 00 rho=0.394 rho039 39 (rho=0.39 p001 p=0.01 01 (p=0.04 β036 β=0.36 36 β039 β=0.39 (p=0.00 β=0.50 β050 0506 0.50 50 β=-0.50 p<0. p0 (p<0. 0.16±0. 0160 0240 0.24±0. p=0.0 rho=0.37 rho03 (rho=0.3 rho=0.45 rho04 4 (rho=0.4 rho=0.39 (p=0.0 β03 β=0.3 β=0.5 β05 050 0.5 5 β=-0.5 p<0 (p<0 0.16±0 016 0.24±0 p=0. rho=0.3 rho0 (rho=0. rho=0.4 (p=0. β0 β=0. 0. β=-0. p< (p< 0.16± 0.24± p=0 rho=0. (rho=0 (p=0 β=0 β=-0 (p 0.16 0.24 p= rho=0 (rho= (p= β=- 0.1 0.2 rho= (rho

https://doi.org/10.1590/1807-3107bor-2024.vol38.0043

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