ABSTRACT Purpose: Although Brazil has a high prevalence of retinoblastoma, there is a lack of epidemiological data on the disease. Thus, in this study, we aimed to evaluate the epidemiological profile of patients diagnosed with retinoblastoma in the ophthalmology department of a pediatric tertiary referral hospital in Ceara, Brazil. Methods: A descriptive and cross-sectional study was conducted by retrospectively analyzing the clinical and socioeconomic data from the medical records of pediatric patients followed-up at the hospital between 2007 and 2021. Retinoblastoma was diagnosed on the basis of a fundoscopic or histopathologic examination. Results: The data of 105 patients were included in the study, and the mean patient age at the time of diagnosis was 1.7 years. Most of the patients were women (50.5%) and hailed from rural areas (57.4%), which was associated with a higher tumor stage. Of the 150 patients, 57.1% initially presented with leukocoria. Ocular hyperemia was associated with more advanced stages of retinoblastoma (p=0.004). Bilateral involvement was observed in 25.7% of the patients and at a significantly younger age (p=0.009). The presence of retinal detachment, vascularized lesions, and vitreous seeds significantly increased the likelihood of requiring enucleation. Discussion: This study presents an epidemiological description of retinoblastoma in Brazil, which highlights the significance of early detection. Delayed diagnosis is associated with a poorer visual prognosis and higher mortality rate, particularly in patients with unilateral disease. Risk factors for a more severe disease were retinal detachment, vascularized lesions, and vitreous seeds. The correlation between histopathological features and clinical outcomes was limited. Conclusion: Further studies are required to assess the influence of ocular hyperemia, fundoscopic assessment, and histopathologic findings on the prognosis of retinoblastoma. Moreover, it is critical to devise interventions to reduce the time-to-diagnosis in rural areas. Purpose Thus Ceara Methods crosssectional cross sectional followedup followed up 200 2021 examination Results 10 17 1 7 1. years 50.5% 505 50 5 (50.5% 57.4%, 574 57.4% , 57 4 (57.4%) stage 15 571 57.1 leukocoria p=0.004. p0004 p p=0.004 . 0 004 (p=0.004) 257 25 25.7 p=0.009. p0009 p=0.009 009 (p=0.009) detachment lesions enucleation Discussion detection rate limited Conclusion assessment Moreover timetodiagnosis 20 202 50.5 (50.5 57.4 (57.4% 57. p000 p=0.00 00 (p=0.004 2 25. (p=0.009 50. (50. (57.4 p00 p=0.0 (p=0.00 (50 (57. p0 p=0. (p=0.0 (5 (57 p=0 (p=0. ( p= (p=0 (p= (p

Resumo A NBR 7190-3 (ABNT, 2022) apresenta diferentes métodos para determinar o módulo de elasticidade da madeira, permitindo a adoção de equivalência entre o módulo de elasticidade na compressão (Ec0) e na tração (Et0). Por outro lado, não apresenta uma forma de estimar o módulo de elasticidade na flexão (EM0), e tais estimativas não consideram a variação das estruturas anatômicas das espécies. Diante dessa lacuna, é necessário avaliar se essas equações são válidas para diferentes espécies. O presente artigo avaliou as propriedades elásticas de três espécies: Cumaru (Dipteryxodorata), Marupá (Simarouba amara Aubl., Simaroubaceae) e Roxinho (Peltogyne spp., Leguminosa). Para isso, realizou-se o ensaio não destrutivo de flexão, seguido de ensaios à compressão e à tração. Imagens microscópicas foram comparadas, para compreender a influência das estruturas anatômicas nas propriedades de rigidez. Os resultados confirmaram a equivalência entre Ec0 e Et0. A maior concentração de parênquimas no Cumaru e no Roxinho é responsável pelos valores estatisticamente inferiores de EM0 em relação ao Ec0 e Et0. 71903 7190 3 7190- ABNT, ABNT (ABNT 2022 madeira Ec (Ec0 Et0 Et . (Et0) lado EM0, EM , (EM0) espécies lacuna Dipteryxodorata, Dipteryxodorata (Dipteryxodorata) Simarouba Aubl Aubl. Simaroubaceae Peltogyne spp spp. Leguminosa. Leguminosa Leguminosa) isso realizouse realizou comparadas rigidez 719 202 (Ec (Et0 (EM0 (Dipteryxodorata 71 20 (Et (EM 7 2

Abstract The NBR 7190-3 (ABNT, 2022) presents various methods to determine the wood's modulus of elasticity, allowing for the adoption of equivalence between the modulus of elasticity in compression (Ec0) and tension (Et0). However, it does not provide a way to estimate the modulus of elasticity in bending (EM0), and such estimates do not consider the variation in anatomical structures among species. Faced with this gap, it is necessary to evaluate whether these equations are valid for different species. This article evaluated the elastic properties of three species: Cumaru (Dipteryx odorata), Marupá (Simarouba amara Aubl., Simaroubaceae) and Roxinho (Peltogyne spp., Leguminosae). For this purpose, a non-destructive flexural test was initially conducted, followed by compression and tension tests. Microscopic images were compared to understand the influence of anatomical structures on stiffness properties. The results confirmed the equivalence between Ec0 and Et0. The higher concentration of parenchyma cells in Cumaru and Roxinho is responsible for statistically lower values of EM0 compared to Ec0 and Et0. 71903 7190 3 7190- ABNT, ABNT (ABNT 2022 woods wood s Ec (Ec0 Et0 Et . (Et0) However EM0, EM , (EM0) species gap Dipteryx odorata, odorata odorata) Simarouba Aubl Aubl. Simaroubaceae Peltogyne spp spp. Leguminosae. Leguminosae Leguminosae) purpose nondestructive non destructive conducted tests 719 202 (Ec (Et0 (EM0 71 20 (Et (EM 7 2

Abstract The consumption of ultra-processed foods has increased globally in recent years. The percentage of calories from these foods is directly associated with the risk of non-communicable chronic diseases. The objective is to evaluate the consumption of ultra-processed foods (UPF) among teachers during the COVID-19 pandemic. This is a cross-sectional study conducted in 2020 in Minas Gerais via digital form. Prevalence ratios between UPF consumption, demographic characteristics, working conditions, lifestyle and health were estimated using Poisson regression. Of the 15,641 teachers, the UPF increase was 27.6%, 28.1% women and 25.6% men. There was a higher prevalence among young women (PR=2.46), without children (PR=1.15), who worked more (PR=1.22), dissatisfied at work (PR=1.25), sedentary (PR=1.25 =1.25), with insomnia (PR=1.57) and overweight (PR=1.12). As for men, there was a higher prevalence among those who were young (PR=1.91), dissatisfied at work (PR=1.40), sedentary (PR=1.17) and insomnia (PR=78). Therefore, it is concluded that there was an increase in UPF consumption.

Resumen El consumo de alimentos ultraprocesados ha aumentado a nivel mundial en los últimos años. El porcentaje de calorías de estos alimentos está directamente asociado con el riesgo de enfermedades crónicas no transmisibles. El objetivo es evaluar el consumo de alimentos ultraprocesados (UPF) entre docentes durante la pandemia de COVID-19. Se trata de un estudio transversal realizado en 2020 en Minas Gerais a través de formulario digital. Los índices de prevalencia entre el consumo de UPF, las características demográficas, las condiciones de trabajo, el estilo de vida y la salud se estimaron mediante regresión de Poisson. De los 15.641 docentes, el incremento de la UPF fue del 27,6%, el 28,1% mujeres y el 25,6% hombres. Hubo mayor prevalencia entre las mujeres jóvenes (RP=2,46), sin hijos (RP=1,15), que trabajaban más (RP=1,22), insatisfechas en el trabajo (RP=1,25), sedentarias (RP=1,25=1,25), con insomnio (RP=1,57) y sobrepeso (RP=1,12). En cuanto a los hombres, hubo mayor prevalencia entre los que eran jóvenes (RP=1,91), insatisfechos en el trabajo (RP=1,40), sedentarios (RP=1,17) e insomnes (RP=78). Por tanto, se concluye que hubo un aumento en el consumo de UPF.

Abstract Introduction and Objectives: Oral food challenges (OFC) are the gold standard for the diagnosis of food allergy. The aim of this study was to characterize and analyze the OFCs performed in the Pediatric Department of the study hospital. Material and Methods: Retrospective analysis of all patients who underwent OFCs in the pediatric department of the study hospital from October 2016 to December 2021. All non-IgE-mediated reactions were excluded. Statistical analysis was performed using IBM Statistical Package for Social Sciences®. Results: A total of 301 OFCs were performed on a total of 172 patients during the study period. Most patients were preschool children (<6 years; 79.4%) and 40.1% had more than one OFC. The most frequently tested allergens were hen’s egg (26.2%), tree nuts (16.9%), and cow’s milk (16.7%). The positivity rate was 23.2%. Tests for milk and wheat were significantly associated with a positive result. The main reason for OFC testing was to establish a diagnosis (60.1%), but also to assess tolerance (25.6%) and to document the responsiveness threshold (14.3%). Most positive reactions were local/grade I (25.7%) or moderate/grade II (58.6%). Patients with a personal history of atopic comorbidities were more likely to have a positive test result (p=0.022), especially those with atopic dermatitis (p=0.022). Discussion and Conclusion: Most OFCs in this analysis were negative. Early recognition of food allergy resolution is essential to prevent unnecessary allergen avoidance. An increased risk of positive reactions to milk or wheat, or in the setting of a personal history of atopic dermatitis, should be considered.

Resumo Introdução e Objetivos: A prova de provocação oral é o gold standard para o diagnóstico de alergia alimentar. Este estudo pretendeu caracterizar e analisar as provas efetuadas no Serviço de Pediatria de um hospital de nível II. Material e Métodos: Estudo retrospetivo dos doentes submetidos a provas de provocação oral entre outubro 2016 e dezembro 2021 num hospital de nível II. As reações não mediadas por IgE foram excluídas. A análise estatística foi realizada através do software IBM Statistical Package for Social Sciences®. Resultados: Foram realizadas 301 provas num total de 172 doentes. A maioria dos doentes eram crianças com idade <6 anos (79,4%) e 40,1% realizou duas ou mais provas. Os alergénios mais frequentemente testados foram ovo (26,2%), frutos secos (16,9%) e leite de vaca (16,7%). Constatou-se que 23,2% das provas foram positivas. Verificou-se uma associação estatisticamente significativa entre as provas realizadas para o leite e trigo e a obtenção de um resultado positivo. Relativamente ao objetivo das provas, 60,1% destinavam-se a estabelecer o diagnóstico, 25,6% a avaliar a tolerância e 14,3% a documentar o limiar de reatividade. A maioria das reações positivas foram locais/grau I (25,7%) ou moderadas/grau II (58,6%). Foi identificada uma associação estatisticamente significativa entre antecedentes de atopia e um resultado positivo nas provas (p=0,022), particularmente antecedentes de dermatite atópica (p=0,022). Discussão: A maioria das provas realizadas foram negativas. O reconhecimento atempado da resolução de uma alergia alimentar permite suspender a evicção desnecessária de alergénios suspeitos. Deve ser considerado o risco acrescido de uma reação positiva com leite, trigo ou em contexto de antecedentes pessoais de dermatite atópica.

Abstract Vanilla planifolia Andrews, is a species subject to special protection, which requires the generation of novel conservation strategies, such as medium-term in vitro conservation, allowing for longer intervals between subcultures, while maintaining the ability to reactivate growth rates. In this sense, works dedicated to the medium-term in vitro conservation of vanilla are mainly focused on the use of osmotic agents, nevertheless, growth inhibitors are a promising mechanism whose use should be evaluated, examples of which are abscisic acid (ABA) and chlormequat chloride (CCC), which have been successfully tested in other species, however, so far there are no reports on the effects of their interaction in vanilla. Therefore, the present study aimed to determine the effect of the interaction of different concentrations of ABA (0, 1.5 and 3 mg L-1) and CCC (0, 1, 2, 2, 4 and 6 mg L-1) added to Murashige and Skoog (MS) medium at 75%, on the inhibition of morphogenesis in vitro culture of Vanilla planifolia microstakes, 1.5 cm in length, subjected to a photoperiod of 16/8 hours light/dark, at 25 ± 2 ºC at 2000 lux light intensity for 200 days, evaluating the total length of the plantlets, the number of shoots, leaves, roots and survival percentage, the best results were obtained in treatment 3.0: 2.0 mg L-1 of ABA/CCC (T 12) because it showed 100% survival, 1.90 cm total length, 0.44 shoots, 1.88 leaves and 1.64 roots. Therefore, the combination of the regulators had a synergistic effect that allowed the medium-term in vitro conservation of V. planifolia by reducing the growth and development of the seedlings without affecting their survival.

Resumen Vanilla planifolia Andrews, es una especie Sujeta a Protección Especial, que requiere la generación de estrategias de conservación novedosas, como la conservación in vitro a mediano plazo, permitiendo alargar los intervalos entre subcultivos, manteniendo la capacidad para reactivar las tasas de crecimiento. En este sentido los trabajos dedicados a la conservación in vitro a mediano plazo de vainilla se encuentran enfocados principalmente en el uso de agentes osmóticos, no obstante, los inhibidores de crecimiento son, un mecanismo promisorio cuyo uso debe evaluarse, ejemplos de ello son el ácido abscísico (ABA) y cloruro de clormequat (CCC), que se han ensayado con éxito en otras especies, sin embargo, hasta el momento no existen reportes sobre los efectos de su interacción en vainilla. Por lo tanto, el presente estudio tuvo como objetivo evaluar el efecto de la interacción de diferentes concentraciones de ABA (0, 1.5 y 3 mg L-1) y CCC (0, 1, 2, 4 y 6 mg L-1) adicionados al medio Murashige y Skoog (MS) al 75%, en la inhibición de la morfogénesis en el cultivo in vitro de microestacas de Vanilla planifolia, de 1.5 cm de longitud, sometidas a un fotoperiodo de 16/8 horas luz/obscuridad, a 25 ± 2 ºC a 2000 lux de intensidad lumínica durante 200 días, evaluando para ello la longitud total de las plántulas, el número de brotes, hojas, raíces y porcentaje de supervivencia, obteniendo los mejores resultados en el tratamiento 3.0: 2.0 mg L-1 de ABA/CCC (T 12) debido a que presentó una supervivencia del 100%, 1.90 cm de longitud total, 0.44 brotes, 1.88 hojas y 1.64 raíces, por lo que, la combinación de los reguladores permitió la conservación in vitro a mediano plazo de V. planifolia al reducir el crecimiento y desarrollo de las plántulas sin afectar su sobrevivencia.

Abstract This study aimed to reflect on the health care offered to women in situations of sexual violence (SV) in two specialized units (SU) in the Brazilian Unified Health System (SUS). Based on a qualitative analysis of interviews with professionals from these SUand participant observations, carried out from November/2021 to August/2022, this study observed problems such as difficulties in approaching subjects of SV and abortion; unpreparedness to welcome women in situations of SV, and network weaknesses. As advances, this research found that multidisciplinary team professionals understand of SV as a social and health problem, workers who serve as positive references for organizing work around SV in SU; the availability of the necessary supplies; and the perception of improvement in the humanization of SV care since the implementation of trace collection at SUS. In addition to technical issues, health care is evidently permeated by sociocultural and gender issues that affect work processes, affecting organizations and the way care is provided. The importance of feminist resistance by professionals in multidisciplinary teams is emphasized due to the urgent need to train sensitive professionals to deal with gender-based violence.

Resumo Neste artigo, buscou-se refletir sobre a atenção ofertada às mulheres em situação de violência sexual (VS) em duas unidades de saúde especializadas (UE) do Sistema Único de Saúde (SUS). A partir da análise qualitativa de entrevistas com profissionais dessas UE e de observações participantes realizadas entre novembro/2021 e agosto/2022, notaram-se problemas como: dificuldades em abordar o tema da VS e do aborto; despreparo para acolher mulheres em situação de VS; e fragilidades na atuação em rede. Como avanços, destacam-se: a compreensão da VS como problema social e de saúde por profissionais das equipes multidisciplinares, que se configuram como referências positivas para organização do trabalho em torno da VS nas UE; a disponibilidade de insumos necessários; e a percepção da melhoria na humanização da atenção à VS, desde a implementação da coleta de vestígios no SUS. É evidente que, para além das questões técnicas, o atendimento à VS é permeado por questões socioculturais e de gênero que atravessam os processos de trabalho, afetando a organização e a forma como o cuidado será ofertado. Enfatiza-se a importância da resistência feminista dos profissionais das equipes multidisciplinares para realização do trabalho e a urgência da formação de profissionais sensíveis para tratar das violências de gênero.

ABSTRACT Purpose: To assess the effect of the coronavirus disease 2019 (COVID-19) pandemic on cataract surgery by residents who had mandatory surgical simulator training during residency. Methods: In this retrospective, observational analytical study, the total number of cataract surgeries and surgical complications by all senior residents of 2019 (2019 class; prepandemic) and 2020 (2020 class; affected by the reduced number of elective surgeries due to the COVID-19 pandemic) were collected and compared. All residents had routine mandatory cataract surgery training on a virtual surgical simulator during residency. The total score obtained by these residents on cataract challenges of the surgical simulator was also evaluated. Results: The 2020 and 2019 classes performed 1275 and 2561 cataract surgeries, respectively. This revealed a reduction of 50.2% in the total number of procedures performed by the 2020 class because of the pandemic. The incidence of surgical complications was not statistically different between the two groups (4.2% in the 2019 class and 4.9% in the 2020 class; p=0.314). Both groups also did not differ in their mean scores on the simulator’s cataract challenges (p<0.696). Conclusion: Despite the reduction of 50.2% in the total number of cataract surgeries performed by senior residents of 2020 during the COVID-19 pandemic, the incidence of surgical complications did not increase. This suggests that surgical simulator training during residency mitigated the negative effects of the reduced surgical volume during the pandemic. Purpose 201 COVID19 COVID 19 (COVID-19 Methods retrospective study (201 prepandemic 202 (202 COVID-1 compared evaluated Results 127 256 respectively 502 50 2 50.2 4.2% 42 4 (4.2 49 9 4.9 p=0.314. p0314 p p=0.314 . 0 314 p=0.314) simulators s p<0.696. p0696 p<0.696 696 (p<0.696) Conclusion increase 20 COVID1 1 (COVID-1 (20 COVID- 12 25 5 50. 4.2 (4. 4. p031 p=0.31 31 p069 p<0.69 69 (p<0.696 (COVID- (2 (4 p03 p=0.3 3 p06 p<0.6 6 (p<0.69 (COVID ( p0 p=0. p<0. (p<0.6 p=0 p<0 (p<0. p= p< (p<0 (p< (p

Resumo Introdução: A necessidade crescente de doadores de órgãos e de profissionais capacitados impulsiona novos estudos que esclareçam o entendimento e comportamento da sociedade perante a doação de órgãos. Estudantes de saúde vêm sendo alvo de estudos por seu influente papel social e, além disso, quando formados, farão parte de etapas fundamentais da doação. Contudo, evidencia-se conhecimento insuficiente dos estudantes apesar de possuírem atitude positiva. Objetivo: Este estudo teve como objetivo avaliar o grau de conhecimento, desejo e atitude perante as doações de órgãos entre os acadêmicos de Medicina e Enfermagem na cidade de Recife, em Pernambuco. Método: Trata-se de um estudo transversal realizado a partir da análise de questionários respondidos por estudantes de Enfermagem e Medicina nos últimos períodos acadêmicos. Além de dados demográficos, os estudantes foram questionados quanto ao entendimento sobre aspectos da validação de possível doador, diretrizes do protocolo de morte encefálica, motivações e opções pessoais em relação à doação de órgãos. Resultado: De fevereiro a dezembro de 2022, 218 questionários foram coletados, dos quais 208 entraram para a amostra. Dentre os estudantes, 57,2% eram do sexo masculino, a média de idade foi de 24 ± 2,7 anos. Dos graduandos, 85,1% cursavam Medicina, e 14,9%, Enfermagem. Apenas 49% dos estudantes sabiam da não necessidade de neurologista para o diagnóstico de morte encefálica. Ademais, 63% não sabiam quem é o responsável por abordar a família do potencial doador. Grande parte dos acadêmicos já considerou a possibilidade de ser doador de órgãos, representando 92,3% do total de estudantes avaliados. Dos alunos, 67% afirmaram já ter conversado com as próprias famílias sobre a doação de órgãos e que elas conheciam essa decisão. Em caso de familiar apresentar diagnóstico de morte encefálica, 83,2% dos alunos consentiram a doação. Em relação aos possíveis benefícios materiais ou emocionais para a família do doador, 86,1% julgam que a doação de órgãos pode trazer algum benefício. Conclusão: Apesar da atitude positiva, o estudo evidenciou conhecimento insuficiente dos alunos, reforçando a necessidade de ampliação do currículo das universidades e criação de cadeiras direcionadas à aquisição de conhecimento e habilidades quanto à condução de casos de morte encefálica e atuação perante os potenciais doadores. Introdução disso formados Contudo evidenciase evidencia se positiva Objetivo Recife Pernambuco Método Tratase Trata demográficos Resultado 2022 21 coletados 20 amostra 572 57 2 57,2 masculino 27 7 2, anos graduandos 851 85 1 85,1 149 14 9 14,9% 49 Ademais 63 923 92 3 92,3 avaliados 67 decisão 832 83 83,2 861 86 86,1 benefício Conclusão 202 5 57, 8 85, 14,9 4 6 92, 83, 86, 14,

Abstract Background: The increasing demand for organ donors and proficient experts is prompting fresh research endeavors aimed at clarifying societal perceptions and actions related to organ donation. Students from the healthcare area have been a focal point in these studies. Despite their favorable attitudes, a notable gap in knowledge among students has been underscored. Objective: To assess the level of knowledge, willingness, and attitudes toward organ donation among medical and nursing students in the city of Recife, Brazil. Methods: A cross-sectional investigation was undertaken, involving the examination of questionnaires that were answered by medical and nursing students during their last academic years. Results: Between February and December 2022, a total of 218 questionnaires were gathered, of which 208 were included in the final sample. Among the participants, 57.2% identified as male, with an average age of 24 ± 2.7 years. In terms of academic background, 85.1% were enrolled in medical school, while 14.9% were attending nursing school. A notable observation was that only 49% of the students were aware that the diagnosis of brain death does not necessarily require the involvement of a neurologist. Furthermore, a significant proportion of students (63%) were unfamiliar with the entity responsible for initiating discussions with the potential donor’s family. Interestingly, 92.3% of the students had contemplated the prospect of becoming organ donors themselves. If a family member were diagnosed with brain death, a significant majority of students, specifically 83.2%, expressed their willingness to grant consent for organ donation. Conclusions: Despite the positive attitudes, this study revealed insufficient knowledge among students, thereby underscoring the need for universities to expand their curricula and establish courses aimed at acquiring knowledge and skills related to brain death cases and actions related to potential donors. Background studies underscored Objective Recife Brazil Methods crosssectional cross sectional undertaken years Results 2022 21 gathered 20 sample participants 572 57 2 57.2 male 27 7 2. background 851 85 1 85.1 school 149 14 9 14.9 49 neurologist Furthermore 63% 63 (63% donor s Interestingly 923 92 3 92.3 themselves 832 83 83.2% Conclusions 202 5 57. 8 85. 14. 4 6 (63 92. 83.2 (6 83. (

Resumo O avanço tecnológico proporcionou a criação de novos espaços de divulgação do conhecimento. Logo, discursos voltados para o ensino de escrita começaram a circular em plataformas digitais com o intuito de propagar conhecimentos relativos à escrita da redação do Enem. A partir disso, o objetivo deste estudo é delinear os imaginários sociodiscursivos que alicerçam o ensino de escrita da redação do Enem de influenciadores digitais, considerando a oferta da aprendizagem como uma mercadoria cultural. Para isso, utiliza-se uma abordagem qualitativa e explicativa, baseando-se na Análise do Discurso, de perspectiva francesa, sobretudo a partir de Charaudeau ( 2017 ), com contribuições pontuais da teoria crítica. Como corpus, foram selecionados três vídeos, tendo como critério as maiores visualizações no YouTube e a palavra-chave de busca: “redação Enem”. As análises apontam para uma movimentação de saberes de conhecimento que, ao serem tecidos, misturam a teoria sobre escrita de textos dissertativos com o manual do Inep e com as experiências próprias de cada influenciador com a prova discursiva do Enem. Esta proposta vaga de ensino de escrita revela uma objetificação do ato de escrever, transformando-o em produto a ser comercializado na medida em que, a partir da empiria, os influenciadores demonstram sucesso próprio no Enem. Logo disso cultural isso utilizase utiliza se explicativa baseandose baseando Discurso francesa 201 , ) crítica corpus vídeos palavrachave palavra chave busca . Enem” tecidos escrever transformandoo transformando empiria 20 2

Abstract Technological advances have given rise to the creation of new spaces for the dissemination of knowledge. Thus, discourses regarding the teaching of writing began to circulate on digital platforms in order to propagate knowledge related to the writing of the Enem essay. Having this in mind, the aim of this study is to delineate the sociodiscursive imaginaries that underpin digital influencers’ teaching of Enem essay writing, considering the offer of the learning process as a cultural commodity. For this purpose, a qualitative and explanatory approach is used, based on Discourse Analysis from French perspective, mostly based on Charaudeau ( 2017 ), with contributions from the concept of Cultural Commodity from Critical Theory. As a corpus, three videos were selected, using as criteria the largest number of views on YouTube and the search keyword "redação Enem" (Enem essay). The analyses point to a movement of expertise-related knowledge that, when woven, mixes the theory on writing discursive texts with the Inep manual, as well as with each influencer’s own experiences with the Enem discursive test. This vague proposal for teaching writing reveals an objectification of the act of writing, transforming it into a product to be marketed to the extent that, from empirical experience, influencers demonstrate their own success in the Enem test. Thus mind commodity purpose used perspective 201 , ) Theory corpus selected redação . essay) expertiserelated expertise woven manual influencer s test experience 20 2

RESUMO Objetivo Verificar a associação de fatores sociodemográficos, do comportamento vocal, morbidades e autopercepção da voz, auditiva e de saúde geral de idosas com distúrbio vocal. Método Participaram 95 idosas com idades entre 60 e 84 anos (média 69,5). Realizou-se uma entrevista com apoio de um questionário estruturado contendo questões sociodemográficas, de saúde e do comportamento vocal. Utilizou-se o Protocolo para Rastreamento de Alterações Vocais em Idosos (RAVI) para identificar a presença de distúrbio vocal. Resultados Houve o predomínio de participantes com ensino médio completo e aposentadas. O número de idosas que apresentaram distúrbio vocal segundo o RAVI foi de 46,3%. Queixas relacionadas às sensações físicas como garganta seca, pigarro e coceira na garganta foram as mais presentes. O grupo de idosas com distúrbio vocal apresentou pior autopercepção da qualidade vocal, audição, saúde geral e maior frequência de infecções de vias aéreas superiores quando comparadas àquelas sem distúrbio vocal (p≤0,05). Conclusão Houve associação estatística entre a autoavaliação vocal mensurada pelo RAVI e a autopercepção da qualidade da voz, da audição, da saúde geral, inflamações de garganta, sinusite e alergias respiratórias. sociodemográficos voz 9 6 8 média 69,5. 695 69,5 . 69 5 69,5) Realizouse Realizou se sociodemográficas Utilizouse Utilizou (RAVI aposentadas 463 46 3 46,3% seca presentes audição p≤0,05. p005 p p≤0,05 0 05 (p≤0,05) respiratórias 69, 4 46,3 p00 p≤0,0 (p≤0,05 46, p0 p≤0, (p≤0,0 p≤0 (p≤0, p≤ (p≤0 (p≤ (p

ABSTRACT Purpose To verify the association between sociodemographic factors, vocal behavior, morbidities, and self-perception of voice, hearing, and general health in older women with voice disorders. Methods The sample had 95 older women aged 60 to 84 years (mean of 69,5). They were interviewed with a structured questionnaire on sociodemographic aspects, health, and vocal behavior. The Screening Protocol for Voice Disorders in Older Adults (RAVI) was used to identify the presence of voice disorders. Results Participants who had finished high school and were retired predominated. The number of older women with voice disorders according to RAVI was 46.3%. Physical sensations such as dry throat, throat clearing, and itchy throat were the most common complaints. The group of older women with voice disorders had worse self-perception of voice quality, hearing, and general health and a higher frequency of upper airway infections than those without voice disorders (p ≤ 0.05). Conclusion The vocal self-assessment measured with RAVI was statistically associated with self-perception of voice quality, hearing, general health, sore throat, sinusitis, and respiratory allergies. factors behavior morbidities selfperception self perception hearing 9 6 8 mean 69,5. 695 69,5 . 69 5 69,5) aspects (RAVI predominated 463 46 3 46.3% clearing complaints quality p 0.05. 005 0.05 0 05 0.05) selfassessment assessment sinusitis allergies 69, 4 46.3 00 0.0 46. 0.

ABSTRACT Purpose: To assess the effect of the Coronavirus disease 2019 (COVID-19) pandemic on cataract surgery by residents who had mandatory surgical simulator training during residency. Methods: In this retrospective, observational analytical study, the total number of cataract surgeries and surgical complications by all senior residents of 2019 (2019 class; prepandemic) and 2020 (2020 class; affected by the reduced number of elective surgeries due to the COVID-19 pandemic) were collected and compared. All residents had routine mandatory cataract surgery training on a virtual surgical simulator during residency. The total score obtained by these residents on cataract challenges of the surgical simulator was also evaluated. Results: The 2020 and 2019 classes performed 1275 and 2561 cataract surgeries, respectively. This revealed a reduction of 50.2% in the total number of procedures performed by the 2020 class because of the pandemic. The incidence of surgical complications was not statistically different between the two groups (4.2% in the 2019 class and 4.9% in the 2020 class; p=0.314). Both groups also did not differ in their mean scores on the simulator’s cataract challenges (p<0.696). Conclusion: Despite the reduction of 50.2% in the total number of cataract surgeries performed by senior residents of 2020 during the COVID-19 pandemic, the incidence of surgical complications did not increase. This suggests that surgical simulator training during residency mitigated the negative effects of the reduced surgical volume during the pandemic. Purpose 201 COVID19 COVID 19 (COVID-19 Methods retrospective study (201 prepandemic 202 (202 COVID-1 compared evaluated Results 127 256 respectively 502 50 2 50.2 4.2% 42 4 (4.2 49 9 4.9 p=0.314. p0314 p p=0.314 . 0 314 p=0.314) simulators s p<0.696. p0696 p<0.696 696 (p<0.696) Conclusion increase 20 COVID1 1 (COVID-1 (20 COVID- 12 25 5 50. 4.2 (4. 4. p031 p=0.31 31 p069 p<0.69 69 (p<0.696 (COVID- (2 (4 p03 p=0.3 3 p06 p<0.6 6 (p<0.69 (COVID ( p0 p=0. p<0. (p<0.6 p=0 p<0 (p<0. p= p< (p<0 (p< (p

Resumo Objetivo Identificar a frequência de lesão renal aguda (LRA) em pacientes hospitalizados com COVID-19, as características associadas, a mortalidade e a letalidade. Métodos Revisão realizada nas bases de dados CINAHL, Embase, LILACS, Livivo, PubMed, SCOPUS, Web of Science e, na literatura cinzenta (Google Acadêmico) em 12 de janeiro de 2022. Foram incluídos artigos em inglês, espanhol e português, publicados a partir de novembro 2019 até janeiro de 2022, em pacientes maiores de 18 anos com COVID-19 hospitalizados e LRA conforme critério Kidney Disease Improving Global Outcomes (KDIGO). Os estudos selecionados foram lidos na íntegra para extração, interpretação, síntese e categorização conforme nível de evidência. Resultados 699 artigos encontrados e 45 incluídos. A idade avançada, sexo masculino, hipertensão, doença renal crônica, ventilação mecânica, aumento da proteína C reativa, uso de drogas vasoativas e de determinadas classes de anti-hipertensivos foram associados a LRA. A LRA está relacionada à maior frequência de mortalidade. Em 30% dos pacientes hospitalizados com COVID-19 houve LRA. A taxa de mortalidade por LRA foi de 5% e a letalidade de 18%. Conclusão Estes resultados ressaltam a relevância da LRA como uma complicação significativa da COVID-19 e sugerem que um controle mais cuidadoso e precoce dos fatores associados poderia potencialmente reduzir a mortalidade e a letalidade. É crucial intensificar a pesquisa nesse campo para esclarecer melhor os mecanismos envolvidos na lesão renal em pacientes com COVID-19, bem como identificar estratégias terapêuticas mais efetivas para sua prevenção e tratamento nesse contexto. (LRA COVID19, COVID19 COVID 19, 19 associadas CINAHL Embase LILACS Livivo PubMed SCOPUS Google Acadêmico 1 2022 inglês português 201 COVID-1 KDIGO. KDIGO . (KDIGO) extração interpretação evidência 69 4 avançada masculino hipertensão crônica mecânica reativa antihipertensivos anti hipertensivos 30 5 18% contexto COVID1 202 20 COVID- (KDIGO 6 3 2

Abstract Objective To identify the frequency of acute kidney injury (AKI) in patients hospitalized with COVID-19, associated characteristics, mortality and lethality. Methods Integrative review carried out in the databases CINAHL, Embase, LILACS, Livivo, PubMed, SCOPUS, Web of Science and in the grey literature (Google Scholar) on January 12, 2022. Articles were included in English, Spanish and Portuguese, published from November 2019 to January 2022, in hospitalized patients over 18 years old with COVID-19 and AKI according to the Kidney Disease Improving Global Outcomes (KDIGO) criteria. The selected studies were read in full for extraction, interpretation, synthesis and categorization according to the level of evidence. Results A total of 699 articles were found and 45 included. Older age, male gender, hypertension, chronic kidney disease, mechanical ventilation, increased C-reactive protein, use of vasoactive drugs and certain classes of antihypertensives were associated with AKI. AKI is related to a higher frequency of mortality. AKI occurred in 30% of patients hospitalized with COVID-19. The mortality rate from AKI was 5% and the case fatality rate was 18%. Conclusion These results highlight the relevance of AKI as a significant complication of COVID-19 and suggest that more careful and early control of associated factors could potentially reduce mortality and lethality. It is crucial to intensify research in this field to better clarify the mechanisms involved in kidney injury in COVID-19 patients, as well as to identify more effective therapeutic strategies for its prevention and treatment in this context. (AKI COVID19, COVID19 COVID 19, 19 characteristics lethality CINAHL Embase LILACS Livivo PubMed SCOPUS Google Scholar 12 2022 English Portuguese 201 1 COVID-1 KDIGO (KDIGO criteria extraction interpretation evidence 69 4 age gender hypertension disease ventilation Creactive C reactive protein 30 COVID19. 19. 5 18% context COVID1 202 20 COVID- 6 3 2

Resumen Objetivo Identificar la frecuencia de lesión renal aguda (LRA) en pacientes hospitalizados con COVID-19, las características relacionadas, la mortalidad y la letalidad. Métodos Revisión realizada en las bases de datos CINAHL, Embase, LILACS, Livivo, PubMed, SCOPUS, Web of Science y en la literatura gris (Google Académico) el 12 de enero de 2022. Se incluyeron artículos en inglés, español y portugués, publicados a partir de noviembre de 2019 hasta enero de 2022, con pacientes mayores de 18 años con COVID-19 hospitalizados y LRA de acuerdo con el criterio Kidney Disease Improving Global Outcomes (KDIGO). Los estudios seleccionados fueron leídos en su totalidad para extracción, interpretación, síntesis y categorización según el nivel de evidencia. Resultados Se encontraron 699 artículos y se incluyeron 45. Los factores relacionados con la LRA fueron: edad avanzada, sexo masculino, hipertensión, enfermedad renal crónica, ventilación mecánica, aumento de la proteína C reactiva, uso de drogas vasoactivas y de determinadas clases de antihipertensivos. La LRA está relacionada con mayor frecuencia de mortalidad. En el 30 % de los pacientes hospitalizados con COVID-19 hubo LRA. La tasa de mortalidad por LRA fue de 5 % y la letalidad de 18 %. Conclusión Estos resultados resaltan la relevancia de la LRA como una complicación significativa de COVID-19 y sugieren que un control más cuidadoso y temprano de los factores asociados podría reducir potencialmente la mortalidad y la letalidad. Es crucial intensificar la investigación en este campo para explicar mejor los mecanismos relacionados con la lesión renal en pacientes con COVID-19, así como identificar estrategias terapéuticas más efectivas para su prevención y tratamiento en este contexto. (LRA COVID19, COVID19 COVID 19, 19 relacionadas CINAHL Embase LILACS Livivo PubMed SCOPUS Google Académico 1 2022 inglés portugués 201 COVID-1 KDIGO. KDIGO . (KDIGO) extracción interpretación evidencia 69 45 avanzada masculino hipertensión crónica mecánica reactiva antihipertensivos 3 contexto COVID1 202 20 COVID- (KDIGO 6 4 2

ABSTRACT Livestock production in semi-arid areas has been unpredictable due to climate variability, mainly rainfall. This study aims to simulate rangeland production variability affected by rainfall over time and relate it to an adjusted carrying capacity, using forage stock to maximize the potential of production of the system to a specifi c guarantee level. Regression analysis of forage biomass against rainfall was performed for ecological sites in the Brazilian semi-arid region to generate probability distribution curves for the historical rainfall for each location using Monte Carlo approach. Forage biomass variability estimated over time was used as input to the model. The system optimizes forage use at a sustainable stocking rate and uses forage surpluses in good years to fill defi cits during adverse years, due to a certain level of guarantee. As a rule, smallholder farmers would need to maintain a storage of around 1,500 kg ha-1 of DM of forage to maintain an adjusted carrying capacity of 0.11 animal units ha-1, with a guarantee of 95% in the long term, stressing the forage storage capacity as a central component of the model. Since farm size infl uences forage production capacity and mainly forage stock capacity, recommendations to cope with this paradigm are suggested. semiarid semi arid approach model rule 1500 1 500 1,50 ha1 ha ha- 011 0 11 0.1 ha1, 1, 95 term suggested 150 50 1,5 01 0. 9 15 5

Resumo Hippocampus reidi representa a espécie mais abundante do gênero na costa brasileira. Apesar de carismáticos, encontram-se globalmente ameaçados devido à degradação de habitat e intensa exploração comercial, especialmente no Brasil, líder na exportação e consumo da espécie. Através de dados mitocondriais (citocromo b e região controle) e nucleares (1st íntron S7), este estudo investigou a variação e estrutura genética de H. reidi em toda a costa brasileira, do estado do Pará até Santa Catarina. Os dados mitocondriais indicam a existência de duas linhagens de H. reidi na costa brasileira: (1) Norte/Nordeste e (2) Sudeste/Sul, padrão parcialmente recuperado pelos dados nucleares. Este cenário pode ser explicado por diferenças na temperatura e padrões de circulação das correntes do Brasil e Norte do Brasil, que definem estes grupos como subprovíncias biogeográficas. As linhagens ocorrem em simpatria no estado da Bahia, o que pode ser explicado pela ocorrência de contato secundário durante o último glacial máximo. Apesar de apresentar duas linhagens, para fins de manejo e conservação, são indicadas três unidades: (1) Norte/Nordeste, (2) Bahia, e (3) Sudeste/Sul. A unidade do Norte/Nordeste mostrou-se a mais vulnerável devido aos baixos índices de diversidade genética apresentados e representa uma prioridade para futuras ações de conservação. brasileira carismáticos encontramse encontram se comercial citocromo controle 1st st S7, S7 S , S7) H Catarina 1 (1 NorteNordeste Nordeste 2 (2 SudesteSul Sudeste Sul Sudeste/Sul biogeográficas Bahia máximo conservação unidades 3 (3 mostrouse mostrou (

Abstract Hippocampus reidi represents the most abundant species of the genus Hippocampus along the Brazilian coast. Despite being charismatic, the species is globally threatened due to habitat degradation and commercial exploration, especially in Brazil, which is the leader in exportation and consumption of the species. Through mitochondrial (cytochrome b and control region) and nuclear (1st intron S7) data, the current study investigates the variation and genetic structure of H. reidi along the Brazilian coast, from Pará to Santa Catarina states. The mitochondrial data indicate the presence of two lineages: (1) North/Northeast and (2) South/Southeast, which was partially recovered by nuclear data. This scenario could be related to temperature differences and circulation patterns of the Brazil and North-Brazil currents, which define these groups into biogeographic sub-provinces. The lineages occur in sympatry in Bahia state, which can be explained by the occurrence of secondary contact during the last glacial maximum. Despite presenting two lineages, for management and conservation, three units are indicated: (1) North/Northeast, (2) Bahia, and (3) South/Southeast. The North/Northeast unit proved to be more vulnerable, presenting the lowest genetic diversity indices, representing a priority for future conservation actions. coast charismatic exploration cytochrome region 1st st S7 S H states 1 (1 NorthNortheast North Northeast 2 (2 SouthSoutheast South Southeast South/Southeast NorthBrazil currents subprovinces. subprovinces sub provinces. provinces sub-provinces state maximum indicated 3 (3 vulnerable indices actions (

RESUMO Objetivo: Encontrar evidências sobre a utilização de N-acetil-cisteína (NAC) no perioperatório de transplante de fígado, uma vez que a NAC, por ser o precursor acetilado da L-cisteína e da glutationa reduzida, colabora no abastecimento hepático de glutationa ajudando o fígado a se recuperar da lesão de isquemia e reperfusão. Metodologia: Trata-se de uma revisão de escopo nas bases de dados PubMed, BVS e Web of Science. Foram utilizados os descritores “Liver transplantation”, “N-acetyl-cysteine” e “Reperfusion Ischemia”, com o operador booleano “AND”, e selecionados artigos de relevância para o tema. Inicialmente, foram selecionados 60 artigos, todos publicados nos últimos 24 anos, em português e/ou inglês. Após análise, oito artigos corresponderam ao objetivo proposto. Resultados: Os grupos que receberam NAC durante o TxF apresentaram hipotensão pós-reperfusão, menores valores de pH intraoperatório, concentrações plasmáticas mais elevadas de IL-4 e aumento significativo dos níveis de IL-10 cinco minutos antes da reperfusão. Observou-se ainda a inibição da α-glutationa S-transferase (α-GST) após a reperfusão, ao contrário do grupo controle, que apresentou aumento significativo dessa enzima. Além disso, os níveis de sVCAM-1 e sICAM-1 foram significativamente mais baixos no grupo NAC 24 horas após a reperfusão em comparação com o grupo placebo. O valor máximo de AST durante as primeiras 72 horas de pós-operatório foi semelhante em ambos os grupos, embora o pico de ALT tenha sido menor no grupo NAC do que no grupo placebo. Em enxertos que receberam o NAC na solução de perfusão, as taxas de sobrevivência aos 3 e 12 meses foram de 93% e 90%, respectivamente, e no grupo controle foram de 82% e 70%, respectivamente. A incidência de complicações pós-operatórias foi de 23% no grupo com o NAC e de 51% no grupo controle. A incidência de DPE foi menor para o grupo NAC, que apresentou 15% versus 32% do grupo controle. Em relação à administração do NAC durante o intraoperatório do TxF, a taxa de sobrevivência dos pacientes em um ano foi de 78,4% no grupo NAC em comparação com 80,9% no grupo placebo. Conclusão: A administração intraoperatória de NAC durante a fase anepática esteve associada a um efeito protetor contra a lesão de reperfusão, contudo em outros estudos foram observadas limitações na proteção contra lesões hepáticas, nos biomarcadores de estresse oxidativo, na inflamação e no funcionamento das enzimas hepáticas. Objetivo Nacetilcisteína N acetil cisteína (NAC Lcisteína L reduzida Metodologia Tratase Trata PubMed Science Liver transplantation, transplantation , transplantation” Nacetylcysteine acetyl cysteine “N-acetyl-cysteine Reperfusion Ischemia, Ischemia Ischemia” AND, AND “AND” tema Inicialmente 6 2 anos eou ou inglês análise proposto Resultados pósreperfusão, pósreperfusão pós pós-reperfusão IL4 IL 4 IL- IL10 10 IL-1 Observouse Observou αglutationa α Stransferase S transferase αGST GST (α-GST enzima disso sVCAM1 sVCAM 1 sVCAM- sICAM1 sICAM sICAM- placebo 7 pósoperatório operatório perfusão 93 90 90% respectivamente 82 70 70% pósoperatórias operatórias 23 51 15 32 784 78 78,4 809 80 9 80,9 Conclusão hepáticas oxidativo “AND IL1 8 5 78, 80,

ABSTRACT Objective: To find evidence on the use of N-acetyl-cysteine (NAC) in the perioperative period of liver transplantation, since NAC, as it is the acetylated precursor of L-cysteine and reduced glutathione, contributes to the hepatic supply of glutathione, helping the liver to recover from ischemia and reperfusion injury. Methodology: This is a scoping review of the PubMed, VHL and Web of Science databases. The descriptors “Liver transplantation”, “N-acetyl-cysteine” and “Reperfusion Ischemia” were used, with the Boolean operator “AND”, and articles relevant to the topic were selected. Initially, 60 articles were selected, all published in the last 24 years, in Portuguese and/or English. After analysis, eight articles corresponded to the proposed objective. Results: The groups that received NAC during TxF showed post-reperfusion hypotension, lower intraoperative pH values, higher plasma concentrations of IL-4 and a significant increase in IL-10 levels five minutes before reperfusion. Inhibition of α-glutathione S-transferase (α-GST) was also observed after reperfusion, unlike the control group, which showed a significant increase in this enzyme. Furthermore, sVCAM-1 and sICAM-1 levels were significantly lower in the NAC group 24 hours after reperfusion compared with the placebo group. The maximum AST value during the first 72 postoperative hours was similar in both groups, although the peak ALT was lower in the NAC group than in the placebo group. In grafts that received NAC in the perfusion solution, survival rates at 3 and 12 months were 93% and 90%, respectively, and in the control group were 82% and 70%, respectively. The incidence of postoperative complications was 23% in the NAC group and 51% in the control group. The incidence of EPD was lower for the NAC group, which was 15% versus 32% in the control group. Regarding the administration of NAC during the intraoperative TxF, the one-year patient survival rate was 78.4% in the NAC group compared to 80.9% in the placebo group. Conclusion: Intraoperative administration of NAC during the anhepatic phase was associated with a protective effect against reperfusion injury, however in other studies limitations were observed in protection against liver injury, in biomarkers of oxidative stress, in inflammation and in the functioning of liver enzymes. Objective Nacetylcysteine N acetyl cysteine (NAC transplantation Lcysteine L glutathione injury Methodology PubMed databases Liver , transplantation” “N-acetyl-cysteine Reperfusion Ischemia used AND, AND “AND” selected Initially 6 2 years andor or English analysis objective Results postreperfusion post hypotension values IL4 IL 4 IL- IL10 10 IL-1 αglutathione α Stransferase S transferase αGST GST (α-GST enzyme Furthermore sVCAM1 sVCAM 1 sVCAM- sICAM1 sICAM sICAM- 7 solution 93 90 90% respectively 82 70 70% 23 51 15 32 oneyear one year 784 78 78.4 809 80 9 80.9 Conclusion stress enzymes “AND IL1 8 5 78. 80.