Abstract The article is the result of an ethnographic research developed with the Arhuaco indigenous people of the Sierra Nevada de Santa Marta in Colombia, between 2017 and 2020, from my participation as an expert witness before the Supreme Court of Justice (highest instance of criminal and penal matters in the country), in the process of seeking justice for the detention, torture and murder of three indigenous authorities in 1990. In the article I analyze the complex process of the Arhuaco people to confront this act of violence, by undertaking a socio-legal mobilization that invoked the presence of the Colombian state with the prosecution of what happened to the three authorities. Colombia 201 2020 highest country, country , country) detention 1990 violence sociolegal socio legal 20 202 199 2 19 1

Resumen El artículo es resultado de una investigación etnográfica desarrollada con el pueblo indígena arhuaco de la Sierra Nevada de Santa Marta en Colombia, entre 2017 y 2020, a partir de mi participación como perita ante la Corte Suprema de Justicia (máxima instancia de los asuntos penales y criminales en el país), en el proceso de búsqueda de justicia por la detención, tortura y asesinato de tres autoridades indígenas en 1990. Sobre la base de esta experiencia pretendo analizar en el artículo el complejo recorrido del pueblo arhuaco para enfrentar este hecho de violencia, al emprender una movilización sociolegal que invocó la presencia del estado colombiano con la judicialización de lo ocurrido a las tres autoridades. Colombia 201 2020 máxima país, país , país) detención 1990 violencia 20 202 199 2 19 1

Abstract Acute Pancreatitis is an unusual side effect of Metformin. The case of a 29-year-old woman with a history of necrotizing Acute Pancreatitis, classified as Baltazar D in 2020, is presented. In March 2021, she experienced another episode of Acute Pancreatitis, this time classified as Baltazar C, without evident necrosis. Investigations did not reveal common causes, but it was noted that, in the two weeks preceding both episodes, the patient had received Metformin treatment for Polycystic Ovary syndrome and Prediabetes, respectively. The successful response involved intravenous fluid administration and discontinuation of the medication, preventing immediate complications, and achieving complete reversal of symptoms. In similar cases, it is crucial to identify risk factors, adjust the dose based on renal function, and closely monitor for any symptoms associated with acute pancreatitis.

Resumen La Pancreatitis Aguda es un efecto secundario inusual de la metformina. Se presenta el caso de una mujer de 29 años con antecedentes de Pancreatitis Aguda Necrotizante Baltazar D en 2020. En marzo de 2021, presenta nuevamente pancreatitis aguda, esta vez clasificada como Baltazar C, sin necrosis evidente. Las investigaciones no revelaron causas habituales, pero se destacó que, en las dos semanas previas a ambos episodios, la paciente había recibido tratamiento con metformina para el síndrome de Ovario Poliquístico y Prediabetes, respectivamente. La respuesta exitosa incluyó la administración de líquidos intravenosos y la suspensión del medicamento, lo cual evitó complicaciones inmediatas y logró una reversión completa de los síntomas. En casos similares, es crucial identificar factores de riesgo, ajustar la dosis según la función renal y realizar una vigilancia estrecha ante cualquier sintomatología asociada con la Pancreatitis Aguda.

Abstract This article interrogates the intersection between writing and visuality in Celan’s poetics, based on the following route: a first section focuses on the impact of his encounter with Gisèle Lestrange, giving an account of Celan’s recognition of the significant imprint that Lestrange’s art of engraving leaves on his own poetic exercise. The growing use of terms from the art of engraving, both in his poetry and in his poetological reflections, will allow us to understand the relationship that the poet maintains with certain forms of critical imagination coming from the visual arts. In a second section, we trace how The Meridian, the title of her decisive poetological manifest, finds its space of germination in an engraving that Lestrange sends to Nelly Sachs, and in whose lines the poet recognizes, as in her correspondence with Celan, «meridians of the pain and consolation». A third section takes up Derrida’s question regarding how to read the practice of language carving in Celan. A final section succinctly addresses the relationship between image and resistance, based on the drawing of burning candles that Celan made as a child and the «call to poets» that he received from the anarchist Gustav Landauer.

Resumen El presente artículo interroga el cruce entre escritura y visualidad en la poética de Celan, a partir del siguiente recorrido: un primer apartado se detiene en la incidencia que tiene su encuentro con Gisèle Lestrange, lo que permite dar cuenta del reconocimiento, por parte de Celan, de la significativa impronta que deja el arte del grabado de Lestrange en su propio ejercicio poético. El creciente uso de términos provenientes del arte del grabado, tanto en su poesía como en sus reflexiones poetológicas, permitirá comprender la relación que el poeta sostiene con ciertas formas de imaginación crítica provenientes de las artes visuales. En un segundo apartado, rastreamos cómo El meridiano, título de su decisivo manifiesto poetológico, encuentra su espacio de germinación en un grabado que Lestrange envía a Nelly Sachs, y en cuyas líneas la poeta reconoce, como apunta en su correspondencia con Celan, «meridianos del dolor y del consuelo». Un tercer acápite retoma la pregunta de Derrida respecto de cómo leer en Celan la práctica de la entalladura del lenguaje. Un último apartado aborda sucintamente la relación entre imagen y resistencia, a partir del dibujo de velas ardiendo que Celan realiza cuando niño y del «llamado a los poetas» que le llega del anarquista Gustav Landauer.

Resumen: Se ha demostrado que las competencias matemáticas tempranas ejercen un rol importante en el aprendizaje de esta disciplina y que tanto la flexibilidad cognitiva como la planificación favorecen este proceso. Sin embargo, la mayoría de las investigaciones han relacionado las funciones ejecutivas con los resultados matemáticos generales, sin tomar en cuenta que esta disciplina incluye diversos componentes que varían en su complejidad cognitiva. Por lo tanto, el objetivo de esta investigación fue evaluar la capacidad predictiva de la flexibilidad cognitiva y la planificación en las competencias matemáticas lógico-relacionales y numéricas de 106 niños de educación inicial de escuelas chilenas, quienes fueron evaluados con dos tareas ejecutivas y un test de competencias matemáticas tempranas. Para el análisis de datos se realizaron correlaciones y modelos de regresión lineal múltiple. Los resultados mostraron que la flexibilidad cognitiva fue un predictor significativo de las competencias matemáticas tanto lógico-relacionales como numéricas, mientras que la planificación lo fue solo de las numéricas. Estos resultados confirman la importancia de la flexibilidad cognitiva y la planificación en el desarrollo de las competencias matemáticas tempranas, lo que podría propiciar intervenciones específicas sobre estas funciones ejecutivas y así favorecer el aprendizaje de las matemáticas en la educación inicial.

Abstract: It has been shown that early mathematical competencies play an important role in the learning of this discipline and that both cognitive flexibility and planning favor this process. However, most research has related executive functions to general mathematical outcomes, without taking into account that this discipline includes several components that vary in their cognitive complexity. Therefore, the aim of this research was to evaluate the predictive capacity of cognitive flexibility and planning in the logical-relational and numerical mathematical competencies of 106 children in early childhood education in Chilean schools, who were evaluated with two executive tasks and a test of early mathematical competencies. Correlations and multiple linear regression models were used for data analysis. The results showed that cognitive flexibility was a significant predictor of both logical-relational and numerical mathematical competencies, while planning was only a significant predictor of numerical competencies. These results confirm the importance of cognitive flexibility and planning in the development of early mathematical competencies, which could lead to specific interventions on these executive functions and thus favor the learning of mathematics in early education.

Resumo: Foi demonstrado que as competências matemáticas precoces desempenham um papel importante na aprendizagem dessa disciplina e que tanto a flexibilidade cognitiva como o planejamento favorecem esse processo. No entanto, a maioria das investigações relacionou as funções executivas com os resultados matemáticos gerais, sem ter em conta que esta disciplina inclui diversos componentes que variam na sua complexidade cognitiva. Por conseguinte, o objetivo desta investigação foi avaliar a capacidade preditiva da flexibilidade cognitiva e do planejamento nas competências matemáticas lógico-relacionais e numéricas de 106 crianças de escolas chilenas de educação infantil, que foram avaliadas com duas tarefas executivas e um teste de competências matemáticas precoces. Foram utilizados correlações e modelos de regressão linear múltipla para a análise de dados. Os resultados mostraram que a flexibilidade cognitiva foi um preditor significativo tanto das competências matemáticas lógico-relacionais como numéricas, enquanto o planejamento foi preditor significativo apenas das competências matemáticas numéricas. Estes resultados confirmam a importância da flexibilidade cognitiva e do planejamento no desenvolvimento de competências matemáticas precoces, o que poderia conduzir a intervenções específicas sobre essas funções executivas, favorecendo assim a aprendizagem da matemática na educação infantil.

ABSTRACT Background: Pathophysiological mechanisms of rheumatoid arthritis arise because of a proinflammatory environment, generated by the interaction of autoreactive lymphocytes and proinflammatory mediators. Current strategies to mitigate the progression of the disease produce adverse effects, so there is a need for new therapeutic strategies and molecular targets to treat this disease. In this context, evidence suggests that scorpion venoms could modulate the immune response and some important cellular mechanisms of pharmacological interest. To evaluate the immunomodulatory effect of the venom of Tityus sp. (a possible new species close to Tityus metuendus) peripheral blood mononuclear cells of women diagnosed with RA were compared to cells of a control group. Methods: A case-control study was conducted with a sample of 10 women with a confirmed diagnosis of RA and controls matched by sex and age. The cytotoxicity of the venom was evaluated to find sublethal concentrations of the venom, and subsequently, their immunomodulatory capacity in terms of percentage of proliferation, cell activation, and cytokines production. Results: the venom of Tityus sp. produced a decrease in the percentage of proliferation in the CD3+, CD3+CD4+, and CD3+CD8+ cell subpopulations of RA patients and healthy controls, at concentrations of 252 and 126 µg/mL. However, the venom did not induce significant differences in the percentage of cell activation markers. The venom caused a decrease in IL-10 at a concentration of 252 µg/mL compared to untreated cells from patients and controls. The remaining cytokines did not show significant differences. Conclusion: the venom of Tityus sp. is a potential source of molecules with immunomodulatory ability in CD4 and CD8 T lymphocytes. This result directs venom characterization studies to identify pharmacological targets with immunomodulatory capacity in T lymphocytes to enhance research in the treatment of autoimmune disorders such as RA. Background environment mediators effects context interest sp metuendus group Methods casecontrol case 1 age subsequently production Results CD3 CD CD3+ CD3CD4 CDCD CD3+CD4+ CD3CD8 CD3+CD8 25 12 µgmL µg mL However markers IL10 IL IL-1 Conclusion CD3CD CD3+CD4 CD3+CD 2 IL1 IL-

RESUMO Este artigo busca refletir sobre a mecanicidade das máquinas produzidas pelos avanços da industrialização no século XIX e de que modo isso provocou uma mudança na subjetividade humana, considerando a relação cartesiana entre corpo e mente traduzida por Gilbert Ryle como “o Fantasma na Máquina” (1966). No que se refere ao lugar do narrador na literatura, propõe-se uma leitura de “Bartleby, o escrivão” (1853), de Herman Melville, e do romance Memórias póstumas de Brás Cubas (1881), de Machado de Assis, como precursores da desconstrução trazida por teóricos do século XX, como Michel Foucault e Roland Barthes. O objetivo é mostrar como a narratividade proposta por Machado e Melville é uma forma de desmantelar a própria narrativa, bem como de produzir crítica social. humana Máquina 1966. 1966 . (1966) literatura propõese propõe Bartleby, Bartleby “Bartleby escrivão 1853, 1853 , (1853) 1881, 1881 (1881) Assis XX Barthes narrativa social 196 (1966 185 (1853 188 (1881 19 (196 18 (185 (188 1 (19 (18 (1 (

ABSTRACT This paper reflects on the mechanicality of machines produced by advances in industrialization in the 19th century and its turn on human subjectivity, considering the Cartesian relationship between body and mind translated by Gilbert Ryle as “the Ghost in the Machine” (1966). Concerning the lieu of the narrator in literature, the premise of this paper is to propose a reading of Herman Melville’s “Bartleby, the Scrivener” (1853) and Machado de Assis’s novel The Posthumous Memoirs of Brás Cubas (1881) as a precursor to the deconstruction brought by 20th-century scholars such as Michel Foucault and Roland Barthes. The aim is to show how the narrativity proposed by Machado and Melville is a way of dismantling the very narrative as well as producing social criticism. th subjectivity Machine 1966. 1966 . (1966) literature Melvilles s Bartleby, Bartleby “Bartleby Scrivener 1853 (1853 Assiss Assis 1881 (1881 20thcentury thcentury 20th Barthes criticism 196 (1966 185 (185 188 (188 19 (196 18 (18 1 (19 (1 (

Resumen: El propósito de este artículo es compartir la discusión sobre el papel fundamental de los elementos constitutivos de la voz en los procesos de diagnóstico y propues tas terapéuticas relacionadas con el TEA. Elementos encontrados en el estudio “Desarrollo de protocolo clínico para el diagnóstico temprano del autismo” (Villalobos y Pacca, 2020). Los casos, Vera y Saul, se retoman para ilustrar el lugar que tiene la voz y la palabra en el desarrollo intersubjetivo. A partir de estos casos se eviden cian los alcances y limitaciones que tienen algunas pruebas para el diagnóstico del TEA al momento de evaluar indicadores comunicativos. Dado que la voz y la palabra llevan la impronta de la subjetividad de cada persona, considerar su análi sis se hace relevante en el diagnóstico comprensivo de TEA, pues complementa la observación diagnóstica propuesta desde las principales pruebas mundialmente reconocidas para esta problemática del desarrollo, como por ejemplo ADOS-2.

Abstract: The purpose of this article is to share the discussion on the fundamental role of the constitutive elements of the voice in the diagnostic processes and thera peutic proposals related to ASD. Elements found in the study “Development of clinical protocol for early diagnosis of autism” (Villalobos & Pacca, 2021). The cases, Vera & Saul, are taken up again to illustrate the place of voice and speech in intersubjective development. From these cases, the scope and limitations of some tests for the diagnosis of ASD when evaluating communicative indicators become evident. Given that voice and speech bear the imprint of each person’s subjectivity, considering their analysis becomes relevant in the comprehensive diagnosis of ASD, as it complements the diagnostic observation proposed by the main tests worldwide recognized for this developmental problem, such as -ADOS-2- Autism Diagnostic Observation Scale-2.

Resumen “Repensar la lectura e investirla de una función crítica”. Con esta fórmula Pic y Alloa dan a pensar el concepto de legibilidad (Lesbarkeit) en Walter Benjamin, enlazado a la irrupción de una sorprendente figura de la lectura: «Leer lo que nunca fue escrito». El presente ensayo da a pensar los alcances de esta fórmula en el encuentro entre Benjamin y Mallarmé, mostrando cómo la lectura de lo no escrito se vincula con la “lectura estrellada” por la experiencia poética del Coup de dés de Mallarmé. La imagen de las constelaciones, lectura de estrellas que nos remite a la infancia de las formas de leer del mundo, permitirá perfilar el “uso imaginativo de la lectura” que se abre paso tanto en la escritura de Mallarmé como en el pensamiento benjaminiano, haciendo que “esta práctica” adquiera una inusitada potencia crítica, incluso revolucionaria.

Abstract “Rethinking reading and investing it with a critical function”. Pic and Alloa present with this formula the concept of legibility (Lesbarkeit) in Walter Benjamin, linked to the irruption of a surprising figure of reading: «Reading what was never written». In the present essay It will be considered the scope of this formula in the encounter between Benjamin and Mallarmé, showing how the reading of the unwritten is linked to the "starry reading" through the poetic experience of Mallarmé's Coup de dés. The image of the constellations, a reading of stars that refers us to the childhood of the world's ways of reading, will allow us to outline the "imaginative use of reading" that makes its way both in Mallarmé's writing and in Benjamin's thought, making that "this practice" acquires an unusual critical, even revolutionary power.

RESUMEN Objetivo. Determinar la seroprevalencia de brucelosis y leptospirosis en cerdos de granjas de pequeña escala en áreas rurales del partido de Tandil, Argentina; analizar los factores de riesgo asociados; describir los serogrupos de Leptospira spp. prevalentes y determinar la distribución espacial de ambas enfermedades. Materiales y métodos. Se obtuvieron 340 muestras de suero. Se utilizaron la prueba de aglutinación en placa, la prueba de Rosa de Bengala y el Test de Polarización de la Fluorescencia para detectar anticuerpos contra Brucella spp. Se aplicó la Prueba de Aglutinación Microscópica para el diagnóstico de leptospirosis. Se utilizaron métodos estadísticos para evaluar los factores asociados a las infecciones. Resultados. Se observaron seroprevalencias de 0 y 22,6% para brucelosis y leptospirosis, respectivamente. Los serogrupos de Leptospira más prevalentes fueron: Canicola, Ballum, Icterohaemorrhagiae y Pomona. Los principales factores de riesgo asociados a la infección por leptospirosis fueron el mayor número de cerdos, la presencia de equinos y la presencia de jabalíes cerca o dentro de las granjas. Se asoció el uso de subproductos de cereal como alimento para los animales y el uso de cajón para el destete. Se detectó un agrupamiento espacial significativo de seropositividad a Leptospira spp. en un área de baja altitud. Conclusiones. La brucelosis probablemente esté controlada, pero Leptospira spp. se encuentra presente en estas producciones. El conocimiento de la seroprevalencia de la brucelosis y la leptospirosis, su distribución espacial y los factores de riesgo asociados puede ser útil para la prevención y el control de enfermedades zoonóticas endémicas en la región.

ABSTRACT Objectives. To determine the seroprevalence of brucellosis and leptospirosis in pigs reared on small-scale farms in rural areas of the district of Tandil, Buenos Aires Province, Argentina; to analyse the associated risk factors; to describe the prevalent Leptospira spp. serogroups; and to determine the spatial distribution of both diseases. Materials and methods. A total of 340 serum samples were obtained. Buffer Plate Agglutination Test, Rose Bengal Test, and Fluorescence Polarisation Assay were used to detect antibodies against Brucella spp. Microscopic Agglutination Test was applied for serological diagnosis of leptospirosis. Statistical methods were used to evaluate the factors associated with the infections. Results. Seroprevalence of 0% and 22.6% was observed for brucellosis and leptospirosis, respectively. The most prevalent Leptospira serogroups identified were Canicola, Ballum, Icterohaemorrhagiae and Pomona. The main risk factors associated with leptospirosis infection were farms with a higher number of pigs and the presence of horses and wild boars near or within the farms. The use of milling by-products of cereal grains as animal feed and the presence of weaning cages were also associated. A relevant spatial cluster of seropositivity to Leptospira spp. was identified in a low-altitude area. Conclusions. Our results suggest that brucellosis is probably controlled, but Leptospira spp. are present in the farming systems under study. Knowledge of brucellosis and leptospirosis seroprevalence, spatial distribution and associated risk factors can be useful for the prevention and control of endemic zoonotic diseases in the region.

Resumen El artículo es resultado de una investigación etnográfica desarrollada con el pueblo indígena arhuaco de la Sierra Nevada de Santa Marta en Colombia, entre 2017 y 2020, a partir de mi participación como perita ante la Corte Suprema de Justicia (máxima instancia de los asuntos penales y criminales en el país), en el proceso de búsqueda de justicia por la detención, tortura y asesinato de tres autoridades indígenas en 1990. Sobre la base de esta experiencia pretendo analizar en el artículo el complejo recorrido del pueblo arhuaco para enfrentar este hecho de violencia, al emprender una movilización sociolegal que invocó la presencia del estado colombiano con la judicialización de lo ocurrido a las tres autoridades. Colombia 201 2020 máxima país, país , país) detención 1990 violencia 20 202 199 2 19 1

Abstract The article is the result of an ethnographic research developed with the Arhuaco indigenous people of the Sierra Nevada de Santa Marta in Colombia, between 2017 and 2020, from my participation as an expert witness before the Supreme Court of Justice (highest instance of criminal and penal matters in the country), in the process of seeking justice for the detention, torture and murder of three indigenous authorities in 1990. In the article, I analyze the complex process of the Arhuaco people to confront this act of violence by undertaking a socio-legal mobilization that invoked the presence of the Colombian state with the prosecution of what happened to the three authorities. Colombia 201 2020 highest country, country , country) detention 1990 sociolegal socio legal 20 202 199 2 19 1

Background: In 2008, the Chilean National Nursing Examination Commission, COENENF, developed a national nursing exam (ENENF). Since 2013, COENENF has implemented a validated opinion survey at the time of the national examination to strengthen the quality of the exam and facilitate its continuous improvement. Aim: To determine the perception of nursing students about general aspects, specific areas, representativeness, mastery and usefulness of the 2018 ENENF. Material and Methods: A descriptive, cross-sectional study, using a self-administered Likert-type survey, was administered in 2018 to 2949 last-year nursing students from 29 nursing schools who took the ENENF. The survey comprised three areas: representativeness of the questions, student mastery of each area, and the usefulness of the exam. Results: Students had a positive perception of the Chilean ENENF and its application. Theoretical knowledge is effectively assessed and close to half of the sample agreed that the ENENF is useful. The results also suggest areas that should be improved. Conclusions: Nursing students had a positive perception of the ENENF.

Abstract Forecasting vehicle traffic flow is considered an important input for traffic planning and management for the countries' intelligent transport systems (ITS). This article analyzes the hourly flow of light vehicle traffic that drives in highway 27 of Costa Rica in one direction (San JoseCaldera). The data collected by the ITS of the route is used to forecast the behavior of hourly vehicular traffic. For this, three forecasting methods are proposed, which are compared to select the model with best performance: Seasonal Arima (SARIMA), Seasonal Naïve (SNAIVE), and Autoregression with Neural Network (NNAR). All three models are evaluated and are considered useful for prediction, however the NNAR model results in better performance when forecasting the hourly time series with the lowest MAPE of 9.4 and is consider a candidate for use in ITS. By applying the cross-validation process in the models, the conclusion is supported that as the NNAR is tested for more days, the prediction results are more stable and accurate.

Resumen El pronóstico de flujo de tráfico vehicular se considera un insumo importante para la gestión y planificación de tráfico para los sistemas de transporte inteligente (STI) de los países. En este artículo se analiza el flujo horario del tráfico de vehículos livianos que circulan en un sentido de la Ruta 27 (San José-Caldera) en Costa Rica. Se aprovechan los datos recolectados por los STI de la ruta para pronosticar el comportamiento de tráfico vehicular horario. Para ello, se proponen tres métodos de predicción, los cuales se comparan para seleccionar el modelo de mejor rendimiento: Arima Estacional (SARIMA), Ingenuo Estacional (SNAIVE)y Autoregresión con Redes Neuronales (NNAR). Los tres modelos de predicción son evaluados y se consideran útiles a la predicción, sin embargo, el modelo de NNAR tiene como resultado un mejor rendimiento al pronosticar la serie de tiempo por hora, teniendo como resultado el menor MAPE de 9.4 y se considera un candidato para ser utilizado en los STI. Al aplicar el proceso de validación cruzada en los modelos, se respalda la conclusión que conforme se prueba el modelo NNAR para más días los resultados de la predicción son más estables y precisos.

Abstract Breast pathology throughout pregnancy and lactation represents a challenge because the physiological changes of mammary tissue during this period may affect the interpretation of clinical and imaging findings. The objective of this presentation is to review the differential diagnosis of breast diseases during pregnancy and lactation. Most of breast pathology during pregnancy and lactation is benign and can be further classified into three categories: 1) those related to physiological changes, 2) inflammatory diseases, and 3) benign tumors. Only 3% of breast cancers will develop during pregnancy. Risk factors for worst prognosis, such as negative hormonal receptors or HER2/neu positive, in pregnant women have similar prevalence than in non-pregnant women of the same age. Early diagnose is of the outmost prognostic importance, therefore it`s important to maintain screening schedule as recommended. It is important to be familiarized with the physiological changes of the breast during pregnancy and lactation, and to know the most prevalent diseases affecting women during this period.

Resumen La patología mamaria durante el embarazo y la lactancia representa un desafío debido a que los cambios fisiológicos del tejido mamario durante este periodo pueden afectar la interpretación de los hallazgos clínicos e imagenológicos. El objetivo de esta revisión es conocer el diagnóstico diferencial de las enfermedades mamarias durante el embarazo y la lactancia. La mayoría de las patologías mamarias durante el embarazo y la lactancia son benignas y pueden ser clasificadas en tres categorías: 1) aquellas relacionadas con cambios fisiológicos, 2) enfermedades inflamatorias y 3) tumores benignos. Solo el 3% de los cánceres mamarios se desarrollan durante el embarazo. Los factores de mal pronóstico, como receptores hormonales negativos o HER2/neu positivo, en las mujeres embarazadas tienen una prevalencia similar a la observada en no embarazadas de la misma edad. El diagnóstico precoz es de crucial importancia pronóstica, por lo que es necesario mantener los esquemas de tamizaje recomendados. Es importante estar familiarizado con los cambios fisiológicos durante el embarazo y la lactancia, y conocer las patologías más prevalentes que afectan a las mujeres durante este periodo.

Resumen La pandemia de COVID-19 causada por el virus SARS-CoV-2 ha generado más de 110,7 millones de infecciones y 2,4 millones de muertes a nivel mundial. Esta infección puede ser asintomática y sus manifestaciones clínicas pueden variar entre leves y graves. Para conocer las posibles asociaciones entre la presencia del virus y las alteraciones histopatológicas encontradas en los tejidos de casos fatales de COVID-19, se evaluó la presencia del virus en el tejido pulmonar de un paciente con antecedentes clínicos de infección por SARS-CoV-2. La muestra se procesó para la detección inmunohistoquímica del virus. En el estudio histopatológico, se observaron cambios morfológicos asociados con neumonitis de origen viral. Asimismo, el virus se localizó principalmente en el citoplasma de las células del infiltrado inflamatorio.

Abstract The COVID-19 pandemic caused by the SARS-CoV-2 virus has generated globally more than 110.7 million infections and 2.4 million deaths. The severity of this infection can range from asymptomatic, mild to severe. To know the possible associations between the presence of the virus and histopathological alterations found in tissues of fatal cases of COVID-19, the presence of the virus in the lung tissue of a patient with a clinical history of SARS-CoV-2 infection was evaluated. Lung tissue was histologically processed for immunohistochemical detection of SARS- CoV-2. In the histopathological study, morphological changes associated with pneumonitis of viral origin were observed. Likewise, the location of the SARS-CoV-2 virus was observed mainly in the cytoplasm of the cells of the inflammatory infiltrate.