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RESUMEN Introducción: La investigación es un proceso intencional de construcción de nuevos conocimientos e ideas, que impulsan la trasformación de la sociedad. Los profesionales de la salud deben desarrollar actitudes positivas hacia la investigación, toda vez que esto mejora su desempeño profesional y, por ende, la calidad de atención al paciente. Objetivo: Identificar las actitudes hacia la investigación en médicos residentes de un hospital pediátrico público. Métodos: Estudio descriptivo transversal; se incluyeron 200 médicos residentes. Se aplicó el instrumento “Escala de actitudes hacia la investigación (EACIN)”, de 39 ítems. Se empleó la prueba t de Student para muestras independientes para determinar la diferencia de los puntajes de las actitudes de investigación y las variables sexo, tipo de especialidad y experiencia laboral; mientras que para la variable horas de trabajo semanal, se empleó la prueba U de Mann-Whitney. Resultados: El 58,5 % fue de sexo femenino; el 25 % (48) mostró una actitud afectiva positiva; el 98 % (196) una actitud cognitiva positiva; el 94 % (188) una actitud conductual positiva. En general, el 96 % (192) tuvo una actitud positiva y el 4 % (8) neutral. El puntaje obtenido por los médicos residentes que realizaban especialidades quirúrgicas fue mayor que el quienes realizaban especialidades clínicas (115,69 ± 6,02 vs. 113,29 ± 5,93; p= 0,012). Conclusiones: La mayor parte de los médicos residentes presentan actitudes positivas hacia la investigación, lo cual podría ser beneficioso para implementar programas de capacitación y actividades relacionadas con la investigación en el hospital.

ABSTRACT Introduction: Research is an intentional process of constructing new knowledge and ideas, promoting the transformation of society. Health professionals must develop positive attitudes towards research since this will improve their professional performance and therefore improve the quality of patient care. Objective: Identify the attitudes towards research in resident doctors of a public pediatric hospital. Methods: The study was descriptive cross-sectional; 200 resident doctors were included. The “Research Attitudes Scale (EACIN)” of 39 items was applied. The T-Student test for independent samples was used to determine the difference in the scores of research attitudes, and the variables sex, type of specialty and work experience, while the Mann Whitney U test was used for the weekly work hours variable. Results: 58.5% were female, 25% (48) showed a positive affective attitude, 98% (196) a positive cognitive attitude, 94% (188) a positive behavioral attitude. In general, 96% (192) had a positive attitude and 4% (8) had a neutral attitude. The score obtained by resident physicians who performed surgical specialties was higher than that of those who performed clinical specialties (115.69 ± 6.02 versus 113.29 ± 5.93; p= 0.012). Conclusions: Most resident doctors have positive attitudes towards research, which could be beneficial to implement training programs and/or activities related to research in the hospital.

Utility of a clinical risk scale to predict the requirement of advanced airway management in patients with a diagnosis of deep neck abscess, abscess
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Gutiérrez, Juan Carlos Méndez

; García-Covarrubias, Luis

; Reding-Bernal, Arturo

; Chong, Héctor A. Velázquez

; Ángel, Diana F. Fernández

; Covarrubias, Aldo García

; Hernández-Rivera, Juan Carlos

Brazilian Journal of Otorhinolaryngology

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2024, Volume 90 N. 2 elocation 101360

Abstract: En | Text: En | PDF: En

Abstract Objectives To analyze the clinical utility of a clinical risk scale to predict the need for advanced airway management in patients with deep neck abscess. Methods Observational, analytical, cross-sectional study. Patients over 18 years old, both genders, with surgical management of a deep neck abscess, between January 1st, 2015 to December 31th, 2021, who were applied the clinical risk scale (https://7-414-5-19.shinyapps.io/ClinicalRiskScore/). The sensitivity, specificity, and predictive values of the scale were calculated based on the identified clinical outcomes. A p < 0.05 was considered significant. Results A sample of 213 patients was obtained, 121 (56.8%) men, of whom 50 (23.5%) required advanced airway management. Dyspnea was the variable with the most statistical weight in our study, (p = 0.001) as well as the multiple spaces involvement, (p = 0.001) the presence of air corpuscles, (p = 0.001) compromise of the retropharyngeal space (p = 0.001) and age greater than 55 years (p = 0.001). Taking these data into account, were found for the clinical risk scale a sensitivity of 97% and a specificity of 65% (p = 0.001, 95% CI 0.856-0.984). Conclusions The clinical risk scale developed to predict advanced airway management in patients with a diagnosis of deep neck abscess may be applicable in our environment with high sensitivity and specificity. Level of evidence: IV. Observational analytical crosssectional cross sectional study 1 old genders 1st st 201 31th th 2021 https//7414519.shinyapps.io/ClinicalRiskScore/. https7414519shinyappsioClinicalRiskScore httpsshinyappsioClinicalRiskScore https //7 414 5 19.shinyapps.io/ClinicalRiskScore/ . 7 19 shinyapps io ClinicalRiskScore (https://7-414-5-19.shinyapps.io/ClinicalRiskScore/) outcomes 005 0 05 0.0 significant 21 obtained 12 56.8% 568 56 8 (56.8% men 23.5% 235 23 (23.5% 0.001 0001 001 involvement corpuscles 0.001. account 97 65 95 0.8560.984. 08560984 0.856 0.984 856 984 0.856-0.984) evidence IV 20 202 7414519 https//7414519.shinyapps.io/ClinicalRiskScore/ shinyappsioClinicalRiskScore // 41 19shinyappsioClinicalRiskScore 19.shinyapps.io/ClinicalRiskScore (https://7-414-5-19.shinyapps.io/ClinicalRiskScore/ 00 0. 2 56.8 (56.8 23.5 (23.5 0.00 000 9 6 8560 0.8560.984 0856098 0856 0.85 0984 0.98 85 98 0.856-0.984 741451 https//7414519.shinyapps.io/ClinicalRiskScore / 4 (https://7-414-5-19.shinyapps.io/ClinicalRiskScore 56. (56. 23. (23. 0.8560.98 085609 085 0.8 098 0.9 0.856-0.98 74145 (56 (23 0.8560.9 08560 08 09 0.856-0.9 7414 (5 (2 0.8560. 0.856-0. 741 ( 0.8560 0.856-0 74 0.856-

https://doi.org/10.1016/j.bjorl.2023.101360

Evaluación preclínica y clínica de SOBERANA® 01. Candidato vacunal contra la COVID-19
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Climent Ruiz, Yanet

; Santana Mederos, Darielys

; PérezRodríguez, Sonia

; Rodríguez González, Meiby de la Caridad

; García Rivera, Dagmar

; Sánchez Ramírez, Belinda

; Valdés Balbín, Yury

; Vérez Bencomo, Vicente

; Rodríguez Noda, Laura M.

; Pérez Nicado, Rocmira

; Ochoa Azze, Rolando

; Boggiano Ayo, Tammy

; Valenzuela Silva, Carmen María

; González Rodríguez, Humberto

; Ramírez González, Ubel J.

; Paredes Moreno, Beatriz

; García Rivera, Daniel

; Labrada Regalado, Claudia

; Hernández García, Tays

; Noa Romero, Enrique

; Díaz Hernández, Marianniz

; OrosaVázquez, Ivette

; BergadoBáez, Gretchen

; Pi Estopiñán, Franciscary

; Hernández Salazar, Tamara

; Fariñas Medina, Mildrey

; Enriquez Puertas, Juliet María

; González Sosa, Nibaldo Luis

; González Delgado, Carlos A.

; Rubino Moreno, Jorman

; Díaz Machado, Alina

; González Freire, Yunior

; Esmoris Mena, Yudisleidy

; Rosales Gil, Lilia Beatríz

; Chappi Estévez, Yanet

; Amoroto Roig, Mayté

; Martínez Pérez, Marisel

; Ontiveiro Pino, Ivis

; Landys Chovel Cuervo, Mario

; Garrido Arteaga, Raine

; Cardoso San Jorge, Félix

; González Mugica Romero, Raúl

; Fernández Castillo, Sonsire

; Ojito Magaz, Eduardo

; Chiodo, Fabrizio

; Paquet, Francoise

; Fang, Cheng

; Guang-Wu, Chen

Anales de la Academia de Ciencias de Cuba

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dec 2023, Volume 13 N. 4 elocation e1512

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

ABSTRACT Introduction: SOBERANA® 01 was developed at the Finlay Vaccine Institute to combat the epidemic caused by the SARS-CoV-2 virus. This candidate is based on the Receptor Binding Domain (RBD) in dimeric form combined with purified vesicles from outer membrane of serogroup B meningococcus as immunopotentiator of the immune response adsorbed on aluminum hydroxide. Methods: The antigen was designed with the peculiarity of having a free cysteine at position 538, which allows the formation of RBD dimers. In preclinical studies it was evaluated the immunogenicity of the dimer combined with the outer membrane vesicles and they were performed toxicological studies. In addition, it was designed a Phase I clinical study in subjects from 19 to 59 years old. Results: The antigenic presentation in the form of dimer combined with the vesicles proved to be safe and immunogenic in animal models, observing a significant increase in the immune response when compared to the monomeric form. During the Phase I clinical evaluation, which included apparently healthy subjects between the ages of 19 and 59, it was demonstrated that SOBERANA® 01 lead to a significant increase in the neutralizing antibody response compared to the use of aluminum hydroxide as the sole adjuvant. After the third dose, 100% of the subjects seroconverted to the group immunized with SOBERANA® 01. Conclusions: It was demonstrated the immunogenicity and neutralizing capacity of the antibodies induced by SOBERANA® 01. The analysis of the sera of the vaccinated persons demonstrated that the formulation containing the OMVs causes a more potent neutralizing effect against several RBD mutants present in VOCs, including the RBD triple mutants of the beta variant.

RESUMEN Introducción: SOBERANA® 01 se desarrolló en el Instituto Finlay de Vacunas para el enfrentamiento a la epidemia causada por el virus SARS-CoV-2. Este candidato se basa en el dominio de unión al receptor en forma dimérica, combinado con vesículas purificadas de membrana externa de meningococo del serogrupo B como inmunopotenciador de la respuesta inmune adsorbidos en hidróxido de aluminio. Métodos: Se diseñó el antígeno con la peculiaridad de tener una cisteína libre en la posición 538, que permite la formación de dímeros del dominio de unión al receptor. En estudios preclínicos se evaluó la inmunogenicidad del dímero combinado con las vesículas de membrana externa y se realizaron estudios toxicológicos. Además, se diseñó un estudio clínico fase I en sujetos de 19 años a 59 años. Resultados: La presentación antigénica en forma de dímero combinado con las vesículas demostró ser segura e inmunogénica en modelos animales observando un incremento significativo de la respuesta inmune cuando se compara con la forma monomérica. Durante la evaluación clínica fase I, que incluyeron sujetos aparentemente sanos de entre 19 años y 59 años de edad, se demostró que SOBERANA® 01 conduce a un aumento importante en la respuesta de anticuerpos neutralizantes en comparación con el uso de hidróxido de aluminio como único adyuvante. Después de la tercera dosis, el 100 % de los sujetos seroconvirtieron en el grupo inmunizado con SOBERANA® 01. Conclusiones: Se demostró la inmunogenicidad y la capacidad neutralizante de los anticuerpos inducidos por SOBERANA® 01. El análisis de los sueros de las personas vacunadas demostró que la formulación que contiene las vesículas de membrana externa provoca un efecto neutralizante más potente contra varios mutantes del dominio de unión al receptor presentes en los COV, incluidos los mutantes triples del dominio de unión al receptor de la variante Beta.

Pseudoaneurismas por drogas intravenosas
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Hernández-Hurtado, Omar A.

; Flores-Ramírez, Carlos

; Hernández-Rivera, Luisa F.

; Molina-Avilés, Gisela

; Berrones-Garza, Marián

; Padilla-Hernández, Leopoldo E.

; Portillo- Aguirre, Ana G.

; González-Plascencia, Felipe R.

; Hinojos-Flotte, Raúl A.

; Delgado-Ortega, Dalia G.

; Mendoza-Romo Ramírez, Miguel A.

; Carrasco-Arredondo, Yarazi M.

; Gallegos-Gardea, Odalis

Revista mexicana de angiología

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sep 2023, Volume 51 N. 3 Pages 77 - 84

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

Resumen Antecedentes: En los pseudoaneurismas infectados de arteria femoral asociados al uso de drogas intravenosas, la ligadura primaria para el tratamiento causa controversia, sin embargo, el territorio comprometido puede continuar irrigado por vías colaterales. Objetivo: Reportar la experiencia del manejo de pseudoaneurismas en un servicio de angiología y cirugía vascular. Métodos: Estudio observacional, descriptivo de una serie de casos. Resultados: Se reportan 15 pacientes, relación hombre: mujer 14:1, promedio de edad de 42 años. Siete (46.6%) con presentación de pseudoaneurisma femoral izquierdo, 5 (33.3%) de ellos con presentación de pseudoaneurisma femoral derecho, 2 (13.3%) con pseudoaneurisma humeral derecho y uno (6.6%) con pseudoaneurisma humeral izquierdo. En 12 se realizó exclusión del pseudoaneurisma con triple ligadura; y 3 pacientes fueron sometidos a revascularización. Conclusiones: En nuestra experiencia, la ligadura primaria sin revascularización tuvo incidencia de amputación baja y supervivencia alta de los pacientes afectados, siendo la claudicación la secuela más frecuente.

Abstract Background: In intravenous drug-infected femoral pseudoaneurysms, primary ligation for treatment is controversial, but the compromised territory can remain irrigated by collateral routes. Objective: To report the experience in the management of pseudoaneurysms in our angiology and vascular surgery service. Methods: Observational, descriptive study of a series of cases. Results: 15 patients are reported, male: female ratio 14:1, average age 42 years. Seven (46.6%) presented with a left femoral pseudoaneurysm, 5 (33.3%) presented with a right femoral pseudoaneurysm, 2 (13.3%) with a right brachial pseudoaneurysm, and one (6.6%) with a left brachial pseudoaneurysm. In 12, exclusion of the pseudoaneurysm was performed with triple ligation; 3 patients underwent revascularization. Conclusions: In our experience the primary ligature without revascularization has a low incidence of amputation and high survival of affected patients, being claudication the most frequent sequel.

https://doi.org/10.24875/rma.23000012

Guía de práctica clínica para el manejo del cáncer de pulmón de células pequeñas: enfermedad extensa
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Cabrera-Miranda, Luis A.

; Díaz-García, Diego A.

; Corona-Cruz, José F.

; Lozano-Ruiz, Francisco J.

; Sánchez-Reyes, Roberto

; Álvarez-Bojórquez, Mario E.

; Blake-Cerda, Mónika

; Rivera-Márquez, Raúl

; López-Saucedo, Raúl A.

; Pérez-Álvarez, Sandra I.

; Bolaño-Guerra, Laura M.

; Alatorre-Alexander, Jorge A.

; Alexander-Meza, Francisco

; Barrón-Barrón, Feliciano

; Blanco-Vázquez, Yazmín C.

; Campos-Gómez, Saúl

; Mata-Moya, Dolores de la

; Figueroa-Martínez, Pedro

; González-Cisneros, Paulina E.

; Íñiguez-García, Marco A.

; Lázaro-León, Jesús M.

; Loyola-García, Ulises

; Morales-Rivera, Marcelino

; Olivares-Torres, Carlos

; Ramos-Ramírez, Maritza

; Sáenz-Frías, Julia A.

; Silva-Bravo, Fernando

; Trejo-Rosales, Rogelio

; Souto-del Bosque, Miguel

; Arrieta, Óscar

Gaceta mexicana de oncología

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jun 2023, Volume 22 N. 2 Pages 55 - 73

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

Resumen Antecedentes: El cáncer de células pequeñas (CPCP) representa el 13-15% del total de neoplasias primarias de pulmón. Se caracteriza por su rapidez en la tasa de crecimiento y en el desarrollo de metástasis a distancia. Objetivos: Orientar y estandarizar el tratamiento del CPCP enfermedad extensa en México basado en evidencia clínica nacional e internacional. Material y métodos: Este documento se desarrolló como una colaboración del Instituto Nacional de Cancerología y la Sociedad Mexicana de Oncología en cumplimiento con estándares internacionales. Se integró un grupo conformado por oncólogos médicos, cirujanos oncólogos, cirujanos de tórax, radio-oncólogos y metodólogos con experiencia en revisiones sistemáticas de la literatura y guías de práctica clínica. Resultados: Se consensaron, por el método Delphi y en reuniones a distancia, las recomendaciones en CPCP enfermedad extensa, producto de preguntas de trabajo. Se identificó y evaluó la evidencia científica que responde a cada una de dichas preguntas clínicas antes de incorporarla al cuerpo de la guía. Conclusión: Esta guía proporciona recomendaciones clínicas para el manejo de la enfermedad extensa del CPCP y durante el proceso de toma de decisiones de los clínicos involucrados con su manejo en nuestro país para mejorar la calidad de la atención clínica para estos pacientes.

Abstract Background: Small cell lung cancer (SCLC) represents 13-15% of all primary lung neoplasms and is characterized by its rapid growth rate and the rapid development of distant metastases. Objectives: To guide and standardize the treatment of extensive disease small cell lung cancer in Mexico based on national and international clinical evidence. Material and methods: This document was developed as a collaboration between the National Cancer Institute and the Mexican Society of Oncology in compliance with international standards. An interdisciplinary group was formed, including medical oncologists, oncological surgeons, thoracic surgeons, radiation oncologists, and methodologists with experience in systematic reviews of the literature and clinical practice guidelines. Results: A consensus was reached, both by the Delphi method and in remote meetings, of extensive disease recommendations resulting from work questions. The scientific evidence that answers each of these clinical questions was identified and critically evaluated, before being incorporated into the body of evidence of the Guide. Conclusions: This Clinical Practice Guide provides clinical recommendations for the management of extensive disease of SCLC to contribute to the decision-making process of the clinicians involved with its management in our country, hoping that this will contribute to improving the quality of clinical care in these patients.

https://doi.org/10.24875/j.gamo.22000122

Guía de práctica clínica para el manejo del cáncer de pulmón de células pequeñas: enfermedad limitada
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Cabrera-Miranda, Luis A.

; Lozano-Ruiz, Francisco J.

; Blake-Cerda, Mónika

; Corona-Cruz, José F.

; Sánchez-Reyes, Roberto

; Pérez-Álvarez, Sandra I.

; Díaz-García, Diego A.

; Álvarez-Bojórquez, Mario E.

; Rivera-Márquez, Raúl

; López-Saucedo, Raúl A.

; Bolaño-Guerra, Laura M.

; Maldonado-Magos, Federico

; Aldaco-Sarvide, Fernando

; Alvarado-Zermeño, Adriana

; Barajas-Figueroa, Luis J.

; Bautista-Aragón, Yolanda

; Bolaños-Morales, Francina V.

; Castillo-Ortega, Graciano

; Félix-Leyva, Jesús A.

; Gerson-Cwilich, Raquel

; Guzmán-de Alba, Enrique

; López-Galindo, Ángel A.

; Mariscal-Ramírez, Carlos

; Piñeiro-Retif, Rafael

; Ramos-Prudencio, Rubí

; Rodríguez-Cid, Jerónimo

; Silva-Bravo, Fernando

; Arrieta, Óscar

Gaceta mexicana de oncología

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mar 2023, Volume 22 N. 1 Pages 3 - 23

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

Resumen Antecedentes: El cáncer de células pequeñas (CPCP) representa el 13-15% del total de neoplasias primarias de pulmón. Se caracteriza por su rapidez en la tasa de crecimiento y en el desarrollo de metástasis a distancia. Objetivos: Orientar y estandarizar el tratamiento del CPCP, enfermedad limitada, en México, basado en evidencia clínica nacional e internacional. Material y métodos: Este documento se desarrolló como una colaboración entre el Instituto Nacional de Cancerología y la Sociedad Mexicana de Oncología en cumplimiento con estándares internacionales. Se integró un grupo conformado por oncólogos médicos, cirujanos oncólogos, cirujanos de tórax, radio-oncólogos y metodólogos con experiencia en revisiones sistemáticas de la literatura y guías de práctica clínica. Resultados: Se consensuaron, por el método Delphi y en reuniones a distancia, las recomendaciones en CPCP enfermedad limitada, producto de las preguntas de trabajo. Se identificó y evaluó críticamente la evidencia científica que responde a cada una de dichas preguntas clínicas, antes de incorporarla a la guía. Conclusión: Esta guía proporciona recomendaciones clínicas para el manejo de la enfermedad limitada del CPCP y durante el proceso de toma de decisiones de los clínicos involucrados con su manejo en nuestro país para mejorar la calidad de la atención clínica en estos pacientes.

Abstract Background: Small cell lung cancer (SCLC) represents 13-15% of all primary lung neoplasms and is characterized by rapid growth rate and development of distant metastases. Objectives: To guide and standardize the treatment of limited disease small cell lung cancer in Mexico based on national and international clinical evidence. Material and methods: This document was developed as a collaboration between the National Cancer Institute and the Mexican Society of Oncology in compliance with international standards. An interdisciplinary group was formed, including medical oncologists, oncological surgeons, thoracic surgeons, radiation oncologists, and methodologists with experience in systematic reviews of the literature and clinical practice guidelines. Results: Consensus recommendations were reached, both by the Delphi method and in remote meetings, for limited SCLC disease resulting from the same number of work questions. The scientific evidence that answers each of these clinical questions was identified and critically evaluated, before being incorporated into the body of evidence of the guide. Conclusion: This guide provides clinical recommendations for the management of limited disease SCLC to contribute to the decision-making process of the clinicians involved with its management in our country, hoping that this will contribute to improving the quality of clinical care in these patients.

https://doi.org/10.24875/j.gamo.22000121

Cross-cultural invariance of the Spanish version of the COVID-19 Assessment Scorecard to measure the perception of government actions against COVID-19 in Latin America Crosscultural Cross cultural COVID19 COVID 19 COVID-1 COVID1 1 COVID-
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Caycho-Rodríguez, Tomás

; Valencia, Pablo D.

; Ventura-León, José

; Carbajal-León, Carlos

; Vilca, Lindsey W.

; Reyes-Bossio, Mario

; Delgado-Campusano, Mariel

; Yupanqui-Lorenzo, Daniel E.

; Paredes-Angeles, Rubí

; Rojas-Jara, Claudio

; Gallegos, Miguel

; Cervigni, Mauricio

; Martino, Pablo

; Polanco-Carrasco, Roberto

; Palacios, Diego Alejandro

; Moreta-Herrera, Rodrigo

; Samaniego-Pinho, Antonio

; Rivera, Marlon Elías Lobos

; Figares, Andrés Buschiazzo

; Puerta-Cortés, Diana Ximena

; Corrales-Reyes, Ibraín Enrique

; Calderón, Raymundo

; Gallegos, Walter L. Arias

; Petzold, Olimpia

; Camargo, Andrés

; Torales, Julio

; Blanco, J. Arkangel Monge

; González, Pedronel

; Smith-Castro, Vanessa

; Rivera, Wendy Yamilet Matute

; Ferrufino-Borja, Daniela

; Ceballos-Vásquez, Paula

; Muñoz-del-Carpio-Toia, Agueda

; Palacios, Jorge

; Burgos-Videla, Carmen

; León, Ana María Eduviges Florez

; Vergara, Ibeth

; Vega, Diego

; Barria-Asenjo, Nicol A.

; Schulmeyer, Marion K.

; Rios, Hassell Tatiana Urrutia

; Lira, Arelly Esther Lira

Psicologia: Reflexão e Crítica

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2023, Volume 36 elocation 34

Abstract: En | Text: En | PDF: En

Abstract Objectives The present study aimed to evaluate the measurement invariance of a general measure of the perception of governmental responses to COVID-|19 (COVID-SCORE-10) in the general population of 13 Latin American countries. Methods A total of 5780 individuals from 13 Latin American and Caribbean countries selected by non-probabilistic snowball sampling participated. A confirmatory factor analysis was performed and the alignment method was used to evaluate invariance. Additionally, a graded response model was used for the assessment of item characteristics. Results The results indicate that there is approximate measurement invariance of the COVID-SCORE-10 among the participating countries. Furthermore, IRT results suggest that the COVID-SCORE-10 measures with good psychometric ability a broad spectrum of the construct assessed, especially around average levels. Comparison of COVID-SCORE-10 scores indicated that participants from Cuba, Uruguay and El Salvador had the most positive perceptions of government actions to address the pandemic. Thus, the underlying construct of perception of government actions was equivalent in all countries. Conclusion The results show the importance of initially establishing the fundamental measurement properties and MI before inferring the cross-cultural universality of the construct to be measured. COVID|19 COVID19 COVID |19 19 COVID-|1 COVIDSCORE10 COVIDSCORE SCORE 10 (COVID-SCORE-10 1 578 nonprobabilistic non probabilistic participated Additionally characteristics COVID-SCORE-1 Furthermore assessed levels Cuba pandemic Thus crosscultural cross cultural measured COVID|1 COVID1 |1 COVID-| COVIDSCORE1 (COVID-SCORE-1 57 COVID-SCORE- COVID| | COVID- (COVID-SCORE- 5 COVID-SCORE (COVID-SCORE

https://doi.org/10.1186/s41155-023-00277-9

Pandemic grief in El Salvador: factors that predict dysfunctional grief due to a COVID-19 death among Salvadoran adults Salvador COVID19 COVID 19 COVID-1 COVID1 1 COVID-
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Lobos-Rivera, Marlon Elías

; Flores-Monterrosa, Angélica Nohemy

; Tejada-Rodríguez, Jennifer Carolina

; Chacón-Andrade, Edgardo René

; Caycho-Rodríguez, Tomás

; Lee, Sherman A.

; Valencia, Pablo D.

; Carbajal-León, Carlos

; Vilca, Lindsey W.

; Reyes-Bossio, Mario

; Gallegos, Miguel

Psicologia: Reflexão e Crítica

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2023, Volume 36 elocation 9

Abstract: En | Text: En | PDF: En

Abstract Thousands of people have died of COVID-19 in El Salvador. However, little is known about the mental health of those who are mourning the loss of a loved one to COVID-19. Therefore, the objective of this study was to examine the dysfunctional grief associated with COVID-19 death among Salvadoran adults. A sample of 435 Salvadorans ( M = 29 years; SD = 8.75) who lost a family member or loved one to COVID-19 completed a digital survey using the Google Forms platform, during April 2 and 28, 2022. The results revealed that 35.1% reported clinically elevated symptoms of dysfunctional grief and among those mourners, and 25.1% also exhibited clinical levels of coronavirus anxiety. A binary logistic regression revealed that predictor variables such as COVID-19 anxiety ( p = .003), depression ( p = .021), and COVID-19 obsession ( p = .032) were significant ( χ 2 = 84.31; Nagelkerke R 2 = .242) and predict a 24.2% chance of dysfunctional bereavement. COVID19 COVID 19 COVID-1 Salvador However COVID19. 19. Therefore adults 43 years 8.75 875 8 75 platform 28 2022 351 35 1 35.1 mourners 251 25 25.1 .003, 003 .003 , .003) .021, 021 .021 .021) .032 032 84.31 8431 84 31 .242 242 24 24.2 bereavement COVID1 COVID- 4 8.7 87 7 202 3 35. 25. 00 .00 02 .02 .03 03 84.3 843 .24 24. 8. 20 0 .0 84. .2 .

https://doi.org/10.1186/s41155-023-00250-6

Asociación del signo de Moore con la presencia de absceso profundo de cuello de espacio retrofaríngeo
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Ruiz-Ruiz, María A.

; García-Covarrubias, Luis

; Romero-Gameros, Carlos A.

; Reding-Bernal, Arturo

; Hernández-Rivera, Juan C.

; Angulo-Pérez, Gabriela

Cirugía y cirujanos

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oct 2022, Volume 90 N. 5 Pages 653 - 658

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Abstract Background: Deep neck abscesses can cause life-threatening complications. They are diagnosed by physical examination, and contrasted tomography as the gold standard. There are no studies about the association of Moore’s sign with infections of the retropharyngeal space. Objective: To determine the usefulness of Moore’s sign in the diagnosis of deep retropharyngeal abscess. Method: Observational, analytical, cross-sectional, study of patients with deep neck abscess, from May 1, 2019, to August 30, 2021, with report of Moore’s sign. Results: 87 patients were included, 49 (56.3%) males (p = 0.45). Of those who developed complications, 77.8% had a negative Moore’s sign (p = 0.001). Of those admitted to the ICU, 72% had a negative Moore’s sign (p = 0.001). The sensitivity of the absence of the sign with retropharyngeal involvement was 95.4%, and the specificity was 86.3%. By logistic regression, it was found that those with retropharyngeal involvement are 467 times more likely to present a negative sign (p < 0.05). Conclusions: The presence of abscess in the retropharynx is associated with complications and a worse prognosis. The evaluation of Moore’s sign can be a useful tool to suspect compromise of this space.

Resumen Antecedentes: Los abscesos profundos de cuello pueden ocasionar complicaciones letales. Se diagnostican por exploración física, y la tomografía contrastada es el método de referencia. No existen estudios de asociación del signo de Moore con infecciones del espacio retrofaríngeo. Objetivo: Determinar la utilidad del signo de Moore en el diagnóstico de absceso profundo en el espacio retrofaríngeo. Método: Estudio observacional, transversal y analítico, de pacientes con absceso profundo de cuello, del 1 de mayo de 2019 al 30 de agosto de 2021, con reporte de signo de Moore. Resultados: Se incluyeron 87 pacientes, de los cuales 49 (56.3%) eran de sexo masculino (p = 0.45). De los que desarrollaron complicaciones, el 77.8%, tenían el signo de Moore negativo (p = 0.001). De los que ingresaron a la unidad de cuidados intensivos, el 72% tenían negativo el signo de Moore (p = 0.001). La sensibilidad de la ausencia del signo con afección del espacio retrofaríngeo fue del 95.4%, y la especificidad del 86.3%. Por regresión logística se encontró que aquellos con afección del espacio retrofaríngeo tienen 467 veces más posibilidades de presentar signo negativo (p < 0.05). Conclusiones: La presencia de un absceso en el espacio retrofaríngeo se asocia a complicaciones y peor pronóstico. La evaluación del signo de Moore puede ser una herramienta útil para sospechar compromiso de ese espacio.

https://doi.org/10.24875/ciru.22000002

10.

Simulaciones electromagnéticas y térmicas de un prototipo de refugio portátil contra descarga eléctrica atmosférica de tipo indirecto
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Rojas, Andres M.

; Rivera, Carlos A.

; Román, Francisco J.

Información tecnológica

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oct 2022, Volume 33 N. 5 Pages 19 - 34

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Abstract: This research study aims to conduct electromagnetic and thermal simulations of a portable shelter prototype against lightning strikes to determine risk factor for the user, based on the regulation IEC 60479-2. Colombia is one of the countries in the world with the highest rates of lightning strikes and victims of this phenomenon, especially in the Colombian National Army. Electromagnetic and thermal simulations of the prototype are performed by using the simulation software CST Microwave Studio®. The results show the induced step voltages and the energy levels achieved by the user, depending on the soil’s resistivity and the prototype’s distance from the impact site of a lightning strike. It is concluded that the shelter prototype is not designed to withstand a direct lightning strike; instead, it can only mitigate the effects of step voltages of an indirect lightning strike.

Resumen: Esta investigación tiene como objetivo realizar simulaciones electromagnéticas y térmicas de un prototipo de refugio portátil contra rayos para determinar los factores de riesgo para el usuario, con base en la norma IEC 60479-2. Colombia es uno de los países en el mundo con los mayores índices de ocurrencia de impactos de rayos y de víctimas por este fenómeno, especialmente en sus fuerzas armadas. Se realizan simulaciones electromagnéticas y térmicas del prototipo en el software de simulación CST Microwave Studio®. Los resultados muestran las tensiones de paso inducidas y los niveles de energía alcanzados por el usuario, en función de la resistividad del suelo y la distancia de ubicación del prototipo con respecto al sitio de impacto del rayo. Se concluye que el prototipo de refugio no fue diseñado para soportar un impacto de rayo de tipo directo; sólo mitiga los efectos por tensiones de paso ante un impacto de rayo de tipo indirecto.

3 downloads

11.

Snack production from apple (Malus domestica B.) and tomatoes (Lycopersicon escullentum Mill) agglomerates by using different thickening agents
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Loyola-López, Nelson E.

; Calquin-Rivera, Leonardo

; Acuña-Carrasco, Carlos A.

; Arriola-Herrera, Mariela A.

International journal of agriculture and natural resources

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apr 2022, Volume 49 N. 1 Pages 51 - 61

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Abstract A snack is a type of food that is of great relevance in the daily diet of persons; it has specific characteristics, such as a crispy texture and a low water content, such as fruits and vegetables. Snacks are easy to handle, carry and store; in particular, they can be immediately consumed anywhere. Therefore, the feasibility of snack production from apples and tomatoes was evaluated. The following thickening agents were added to each treatment: apples, tomatoes and guar gum (T1); apples, tomatoes and carrageenan (T2); and apples, tomatoes and honey (T3). The raw materials were apples and tomatoes, and they underwent a dehydration process with forced air; then, the different snacks were subjected to physical-chemical evaluations, such as pH, dietary fiber, soluble solids and acidity. A sensorial evaluation was carried out for each treatment by trained panelists who considered the intensity of the attributes, such as color, texture, smell and flavor, as well as the acceptability of the final product. The hypothesis was partially supported under the assay considerations. The best result was achieved when honey was used as a thickening agent (T3); the snacks presented a crispy texture. The products produced from treatment T3 had a better evaluation of their sensorial and acceptability characteristics.

Resumen El snack es un tipo de alimento que día a día toma mayor relevancia en la vida y dieta de las personas, cuenta con características específicas, como, por ejemplo, contiene una baja cantidad de agua y una textura crocante en el caso de las frutas u hortalizas. Snack es un tipo de alimento de fácil manejo, ya sea para transportar o almacenar y sobre todo permite que su consumo sea rápido e inmediato. Es por lo anterior que se evaluó la factibilidad de realizar un snack, elaborado sobre la base de manzana y tomate, con diferentes agentes espesantes en cada tratamiento, utilizando las siguientes formulaciones: manzana, tomate y goma guar (T1); manzana, tomate y carragenina (T2); manzana, tomate y miel (T3). Las materias primas utilizadas manzana y tomate, se llevaron a un proceso de deshidratación con aire caliente forzado, para eliminar gran parte del contenido de agua presente en cada especie. Posteriormente los diferentes snacks elaborados, se llevaron a evaluaciones físicos-químicos, tales como; fibra dietética, pH, sólidos solubles y acidez. Se realizó una evaluación sensorial a cada tratamiento, por panelistas entrenados quienes percibieron la intensidad de los atributos; color, textura, aroma y sabor, como también la aceptabilidad del producto obtenido. La hipótesis se cumplió parcialmente, según las condiciones del ensayo. Los resultados donde se utilizó miel como agente espesante (T3), presentó una textura crocante. Los productos elaborados con el tratamiento T3 tuvieron una mejor evaluación de los atributos sensoriales y de aceptabilidad.

https://doi.org/10.7764/ijanr.v49i1.2293 18 downloads

12.

Trophic assessment of four tropical reservoirs using phytoplankton genera
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Rivera, Carlos A.

; Zapata, Angela

; Villamil, William

; León-López, Nubia

Acta Limnologica Brasiliensia

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2022, Volume 34 elocation e26

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo: Objetivo O monitoramento do estado trófico de reservatórios requer índices que forneçam um relatório rápido do ecossistema aos tomadores de decisão. Este estudo teve como objetivo desenvolver um sistema de indicadores de estado trófico para reservatórios de montanha tropical usando gêneros de fitoplâncton. Métodos Entre 2004 e 2010, foram monitorados quatro reservatórios para abastecimento de água em Bogotá (Colômbia), que apresentam diferentes estados tróficos e gestão hidráulica. Amostras foram coletadas para análise de variáveis físicas e químicas e comunidade fitoplanctônica. Por meio de análise multivariada, estabeleceu-se a significância das relações entre variáveis ambientais e espécies e gêneros fitoplanctônicos. Posteriormente, os índices tróficos foram propostos como variáveis relevantes. O índice trófico global foi calculado como a soma dos índices parciais. Resultados A análise dos principais componentes mostrou que os reservatórios variam quimicamente dependendo do estado trófico. O fitoplâncton foi composto por 63 gêneros, 59% dos quais estavam presentes nos quatro reservatórios. Embora as características físicas da água, como temperatura e teor de sólidos totais, explicassem grande parte da variação dos gêneros, observou-se em cada reservatório uma relação significativa entre os gêneros e as variáveis relacionadas ao estado trófico. As análises multivariadas agrupando os dados por gênero mostraram um comportamento semelhante à análise utilizando informações em nível de espécie. Os índices de estado trófico do plâncton foram desenvolvidos para fósforo (TP), nitrogênio Kjeldahl total (TKN), carbono orgânico total (TOC) e disco de Secchi (SD) usando dados agrupados por gêneros. Os índices foram significativamente correlacionados com os valores de cada variável em cada reservatório. Modelos de regressão linear mostraram um poder preditivo significativa de clorofila-a usando os índices TP, TKN e SD nos três reservatórios com maior nível trófico. Além disso, o índice global apresentou relação significativa com variáveis relacionadas ao estado trófico. Conclusões Os dados do fitoplâncton em nível de gênero podem ser usados para avaliar o estado trófico. Os modelos para SD, TP e TKN podem ser utilizados como indicadores do estado trófico dos reservatórios estudados.

Abstract: Aim Monitoring the trophic state of reservoirs requires indices that provide a quick report of the ecosystem to decision makers. This study aimed to develop a system of trophic status indicators for tropical mountain reservoirs using phytoplankton genera. Methods Between 2004 and 2010, four reservoirs for water supply in Bogotá (Colombia), which have different trophic statuses and hydraulic management, were monitored. Samples were collected for the analysis of physical and chemical variables and phytoplankton community. Through multivariate analysis, the significance of the relationships between environmental variables and phytoplankton species and genera was established. Subsequently, trophic indices were proposed as relevant variables. The global trophic index was calculated as the sum of the partial indices. Results Analysis of the main components showed that reservoirs varied chemically depending on trophic status. Phytoplankton were composed of 63 genera, 59% of which were present in the four reservoirs. Although the physical characteristics of water, such as temperature and total solids content, explained a large part of the variation in the genera, a significant relationship between the genera and variables related to trophic state was observed in each reservoir. The multivariate analyses grouping the data by genera showed a behavior similar to the analysis using information at the species level. Plankton indices of trophic state were developed for phosphorus (TP), total Kjeldahl nitrogen (TKN), total organic carbon (TOC), and Secchi disk (SD) using data grouped by genera. The indices were significantly correlated with the values of each variable in each reservoir. Linear regression models showed a significant prediction of chlorophyll-a using TP, TKN, and SD indices in the three reservoirs with the highest trophic level. In addition, the global index showed a significant relationship with variables related to the trophic state. Conclusions Phytoplankton data at the genus level can be used to assess trophic status. The models for SD, TP, and TKN could be used as indicators of the trophic status of the studied reservoirs.

https://doi.org/10.1590/s2179-975x11820

13.

Epilithic diatoms (Bacillariophyceae) in a tropical Andean River of Southwest Colombia
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Ospina, María Isabel

; Peña-Salamanca, Enrique J.

; Rivera-Rondón, Carlos A.

Rodriguésia

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2022, Volume 73 elocation e02082020

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo En regiones tropicales hay una gran cantidad de especies de diatomeas que todavía no han sido identificadas. Esta investigación tuvo como objetivo estudiar la composición de la flora de diatomeas epilíticas encontradas en muestras recolectadas en el río Dagua, una cuenca hidrográfica andina tropical, ubicada suroeste de Colombia. Los muestreos se realizaron en tres estaciones con sus respectivas tres réplicas entre enero y abril de 2018 para recolectar muestras para la identificación de diatomeas (Clase Bacillariophyceae). Estas muestras se analizaron con microscopía óptica y microscopía de contraste interferencial. Los resultados indicaron la presencia de 18 taxa distribuidos en 9 familias y 11 géneros. Dos de estas, son nuevos registros para Colombia: Navicula incarum y Fragilaria aff. socia. El género con mayor riqueza específica fue Navicula. Una comparación con la flora de diatomeas de la región muestra que se registraron nueve especies en común con el Río Cali.

Abstract In tropical regions there are a large number of species of diatoms that have not been identified yet. This research aimed to study the composition of epilithic diatom flora found in samples collected in Dagua River a tropical Andean hydrographical basin located to the southwest of Colombia. Samplings were performed in three stations with their respective three replicas between January and April 2018 to collect samples for identification of diatom (Class Bacillariophyceae). These samples were analyzed with light microscopy and interferential contrast microscopy. The results indicated the occurrence of 18 taxa distributed in 9 families and 11 genera. Two of these are new records for Colombia: Navicula incarum and Fragilaria aff. socia. The most species-rich genera was Navicula. A comparison with the diatom flora of the region shows that 9 species were recorded in common with the Cali River.

https://doi.org/10.1590/2175-7860202273076

14.

Guía de práctica clínica mexicana para el diagnóstico y tratamiento de las dislipidemias y enfermedad cardiovascular aterosclerótica
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Pavía-López, Abel A.

; Alcocer-Gamba, Marco A.

; Ruiz-Gastelum, Edith D.

; Mayorga-Butrón, José L.

; Mehta, Roopa

; Díaz-Aragón, Filiberto A.

; Aldrete-Velasco, Jorge A.

; López-Juárez, Nitzia

; Cruz-Bautista, Ivette

; Chávez-Mendoza, Adolfo

; Secchi-Nicolás, Nikos C.

; Guerrero-Martínez, Francisco J.

; Cossio-Aranda, Jorge E.

; Mendoza-Zubieta, Victoria

; Fanghänel-Salmon, Guillermo

; Valdivia-Proa, Martha

; Olmos-Domínguez, Luis

; Aguilar-Salinas, Carlos A.

; Dávila-Maldonado, Luis

; Vázquez-Rangel, Armando

; Pavia-Aubry, Vanina

; Nava-Hernández, María de los A.

; Hinojosa-Becerril, Carlos A.

; Anda-Garay, Juan C.

; Ríos-Ibarra, Manuel O. de los

; Berni-Betancourt, Ana C.

; López-Cuellar, Julio

; Araiza-Garaygordobil, Diego

; Rivera-Reyes, Romina

; Borrayo-Sánchez, Gabriela

; Tapia-Hernández, Mónica

; Cano-Nigenda, Claudia V.

; Guerra-López, Arturo

; Elías-López, Josué

; Figueroa-Morales, Marco A.

; Montaño-Velázquez, Bertha B.

; Velasco-Hidalgo, Liliana

; Rodríguez-Lozano, Ana L.

; Pimentel-Hernández, Claudia

; Baquero-Hoyos, María M.

; Romero-Moreno, Felipe

; Rodríguez-Vega, Mario

Archivos de cardiología de México

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2022, Volume 92 Suppl. 1 Pages 1 - 62

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

resumen está disponible en el texto completo

Abstract Background: Cardiovascular diseases are the leading cause of mortality worldwide and Mexico is no exception. The epidemiological data obtained in 1990 showed that cardiovascular diseases represented 19.8% of all causes of death in our country. This figure increased significantly to 25.5% for 2015. Some national surveys suggest that more than 60% of the adult population has at least one risk factor for cardiovascular disease (obesity or overweight, hypertension, smoking, diabetes, dyslipidemias). On the other hand, data from the Pan American Health Organization have linked the process of atherosclerosis as the first cause of premature death, significantly reducing life expectancy, which has enormous social repercussions. Objective: This document constitutes the Clinical Practice Guide (CPG) prepared at the initiative of the Mexican Society of Cardiology in collaboration with the Mexican Society of Nutrition and Endocrinology, AC, National Association of Cardiologists of Mexico, AC, Mexican Association for the Prevention of Atherosclerosis and its Complications, AC, National Normative Committee of General Medicine, AC, National College of Geriatric Medicine, AC, College of Internal Medicine of Mexico, AC, Mexican Society of Angiology and Vascular and Endovenous Surgery, AC, Mexican Institute of Research Nephrological, AC and the Mexican Academy of Neurology, A.C.; with the methodological support of the Ibero-American Agency for the Development and Evaluation of Health Technologies, in order to establish recommendations based on the best available evidence and agreed upon by an interdisciplinary group of experts. The objective of this document is to provide evidence-based recommendations to help decision makers in the diagnosis and treatment of dyslipidemias in our country. Material and methods: This document complies with international quality standards, such as those described by the Institute of Medicine of the USA, the Institute of Clinical Excellence of Great Britain, the Scottish Intercollegiate Guideline Network and the Guidelines International Network. A multidisciplinary group of clinical experts and methodologists with experience in systematic reviews of the literature and the development of clinical practice guidelines was formed. A scope document was agreed upon, relevant clinical questions were established, the best available evidence critically evaluated in systematic literature reviews was exhaustively identified, and clinical recommendations were developed. The modified Delphi Panel methodology was used to achieve an adequate level of consensus in each of the recommendations contained in this CPG. Results: 23 clinical questions were agreed upon which gave rise to their respective clinical recommendations. Conclusions: We consider that this document contributes to better clinical decision-making and becomes a point of reference for clinicians and patients in the management of dyslipidemias and this contributes to reducing the morbidity and mortality derived from atherosclerotic cardiovascular events in our country.

https://doi.org/10.24875/acm.m22000081 1458 downloads

15.

Estudios colaborativos multicéntricos en cirugía: ¿qué sucede en Latinoamérica?
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Boccalatte, Luis A.

; Modolo, María Marta

; Calvache, José A.

; Lincango-Naranjo, Eddy P.

; Ataíde-Gomes, Gustavo M.

; Lima-Buarque, Igor

; Pérez-Rivera, Carlos J.

; Shu-Yip, Sebastián B.

; Vásquez-Ojeda, Ximena P.

; Olivos, Maricarmen

; Batista, Sylvia

; Aguilera-Arévalo, María Lorena

; Gómez-Fernández, Hugo

; Arévalo, Danilo

; Nepogodiev, Dimitri

; Picciochi, Maria

; Simoes, Joana

Cirugía y cirujanos

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dec 2021, Volume 89 N. 6 Pages 733 - 739

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Abstract Background: GlobalSurg is an international group of researchers whose purpose is to conduct and disseminate robust collaborative, international and multicenter studies. Objective: To expose the necessary strategies and the barriers crossed in conducting massive multicenter studies in surgery. Method: During the second semester of 2020, the study Surg-Week Prospective International Cohort Study was carried out. Surg-Week has been the largest international study in the field of surgery to date, with 141,582 patients included. A total of 4975 mini-teams, of between 1 and 5 members, collected data from 116 countries on all continents. Results: The creation of an official website for the study, reports with relevant information via email or groups via WhatsApp, formation of a Dissemination Committee of the protocol, delivery of webinars on recent team publications, appointment of leaders at the national and international level, and outreach through partnerships, were the strategies used for the development of the research. However, the barriers turned out to involve different aspects. Conclusions: Collaborative work allows establishing networks between different professionals with the goal of improving the quality of management, health policies and care of our patients in a timely manner of constant change.

Resumen Antecedentes: GlobalSurg es un grupo internacional de investigadores que tiene como propósito la conducción y la diseminación de robustos estudios colaborativos, internacionales y multicéntricos. Objetivo: Exponer las estrategias necesarias y las barreras encontradas en la conducción de estudios multicéntricos masivos en cirugía. Método: Durante el segundo semestre del año 2020 se llevó a cabo el estudio Surg-Week Prospective International Cohort Study, hasta la fecha el estudio internacional más grande en el campo de la cirugía, con 141,582 pacientes incluidos. Un total de 4975 miniequipos, de uno a cinco integrantes, recopilaron datos de 116 países de todos los continentes. Resultados: La creación de un sitio web oficial del estudio, reportes con información relevante vía e-mail o grupos vía WhatsApp, conformación de un comité de diseminación del protocolo, dictado de webinars sobre publicaciones recientes del equipo, designación de líderes nacionales e internacionales, y la divulgación por medio de sociedades, fueron las estrategias utilizadas para el desarrollo de la investigación. Sin embargo, las barreras detectadas para llevar a cabo el estudio multicéntrico fueron variadas. Conclusiones: Los trabajos colaborativos permiten establecer redes entre diferentes profesionales con el fin de mejorar la calidad de la gestión, las políticas sanitarias y la atención a los pacientes en tiempos de constante cambio.

https://doi.org/10.24875/ciru.21000282 16 downloads

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