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1.
Optimization of ultrasound-assisted extraction of anthocyanins from purple tomatoes ultrasoundassisted ultrasound assisted
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RESUMO: Este estudo teve como objetivo otimizar a extração assistida por ultrassom (EAU) de antocianinas totais de dois estágios de maturação de tomates roxos (baixo e alto) e comparar a extração otimizada com a convencional. Na otimização da EAU, as variáveis estudadas foram tempo (5 a 75 min), temperatura (30 a 70 °C) e razão sólido:líquido (1:5 a 1:15 m/v). A condição otimizada da EAU, para tomates roxos em baixa maturação, ocorreu no tempo de 75 min, temperatura de 40 °C e razão sólido:líquido de 1:15 m/v, prevendo o teor de 12,487 mg/100 g. Para tomates roxos em alta maturação, a condição ideal ocorreu no tempo de 40 min, temperatura de 50 °C e razão sólido:líquido de 1:15 m/v, prevendo o teor de 8,802 mg/100 g. Na validação das condições otimizadas, foi encontrada uma diferença inferior a 3% entre os valores previstos e experimentais (12,267 mg/100g para baixa-maturação e 8,894 mg/100 g para alta-maturação). Ao comparar a EAU otimizada com a convencional, observou-se que a EAU aumentou (P < 0,05) a extração de antocianinas totais em 73% para tomates em baixa-maturação e 54% para tomates roxos em alta-maturação. Assim, o estudo indica que os EAU é uma tecnologia eficiente para a recuperação de antocianinas de tomates roxos. RESUMO (EAU baixo alto convencional 5 ( 7 min , min) 30 (3 C sólidolíquido sólido líquido 15 1 (1: 115 1:1 m/v. mv m/v . m v m/v) 4 12487 12 487 12,48 mg100 mg 100 mg/10 8802 8 802 8,80 otimizadas 3 12,267 12267 267 (12,26 mg100g mgg 100g baixamaturação 8894 894 8,89 altamaturação. altamaturação alta-maturação) observouse observou se P 0,05 005 0 05 73 54 maturação. alta-maturação Assim (1 11 1: 1248 48 12,4 mg10 10 mg/1 880 80 8,8 12,26 1226 26 (12,2 889 89 0,0 00 124 12, mg1 mg/ 88 8, 12,2 122 2 (12, 0, (12
ABSTRACT: This study aimed to optimize the ultrasound-assisted extraction (UAE) of total anthocyanins from two stages of ripening purple tomatoes (low and high) and to compare the optimized extraction with the conventional one. In the optimization of UAE, the studied variables were time (5 to 75 min), temperature (30 to 70 °C), and solid: liquid ratio (1:5 to 1:15 m/v). The optimal condition of the UAE process, for low-ripened purple tomatoes, occurs at a time of 75 min, temperature of 40 °C, and solid: liquid ratio of 1:15 m/v, predicting the content of 12.487 mg/100g. For high-ripened purple tomatoes, the optimal condition occurs at a time of 40 min, temperature of 50 °C, and solid: liquid ratio of 1:15 m/v, predicting the content of 8.802 mg/100 g. On validation of these optimized conditions, less than a 3% difference was reported between the predicted and experimental values (12.267 mg/100 g for low-ripened, and 8.894 mg/100 g for high-ripened purple tomatoes). When comparing the optimized UAE with the conventional extraction, it was observed that UAE increased (P < 0.05) the extraction of total anthocyanins content by 73% for low-ripened and by 54% for high-ripened purple tomatoes. Thus, the study indicated that the UAE is an efficient technology for recovering bioactive compounds from purple tomatoes. ABSTRACT ultrasoundassisted ultrasound assisted (UAE low high one 5 ( 7 min , min) 30 (3 C °C °C) solid 15 1 (1: 115 1:1 m/v. mv m/v . m v m/v) process lowripened ripened 4 12487 12 487 12.48 mg100g mgg mg 100g mg/100g highripened 8802 8 802 8.80 mg100 100 mg/10 conditions 3 12.267 12267 267 (12.26 lowripened, ripened, 8894 894 8.89 tomatoes) P 0.05 005 0 05 73 54 Thus (1 11 1: 1248 48 12.4 880 80 8.8 mg10 10 mg/1 12.26 1226 26 (12.2 889 89 0.0 00 124 12. 88 8. mg1 mg/ 12.2 122 2 (12. 0. (12
2.
Desenvolvimento de um design de telessimulação para o suporte básico de vida
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Bernardinelli, Fabiana Cristina Pires
; Amorim, Gustavo Correa de
; Nascimento, Juliana da Silva Garcia
; Fonseca, Luciana Mara Monti
; Domingues, Tânia Arena Moreira
; Condeles, Paulo César
; Chavaglia, Suzel Regina Ribeiro
.
Resumen Objetivo Elaborar y validar un diseño de telesimulación sincrónica y observacional de enfermería para la atención de acuerdo con el protocolo de soporte vital básico intrahospitalario en adultos. Métodos Estudio metodológico basado en las fases del procedimiento teórico realizado por medio de una scoping review, fase empírica llevada cabo a través de la validación de contenido del diseño telesimulado y fase analítica en la que se adoptó el índice de validez de contenido. Resultados Se elaboró un diseño para la atención de acuerdo con el protocolo de soporte vital básico que atravesó seis etapas: planificación, preparación, participación, teledebriefing, evaluación y feedback y aprendizaje adicional, con un Índice de Validez de Contenido de 0,96. Conclusión El diseño elaborado fue considerado válido en contenido para planificar y ejecutar la telesimulación por parte de enfermeros y además puede adaptarse a otros contextos educativos. adultos review etapas planificación preparación participación teledebriefing adicional 096 0 96 0,96 educativos 09 9 0,9 0,
Resumo Objetivo Construir e validar um design de telessimulação síncrona e observacional em enfermagem para o atendimento segundo o protocolo de suporte básico de vida intra-hospitalar no adulto. Métodos Estudo metodológico baseado nas fases do procedimento teórico realizado por meio de uma scoping review; fase empírica desenvolvida através da validação de conteúdo do design telessimulado e fase analítica em que adotou-se o índice de validade de conteúdo. Resultados Construiu-se um design para o atendimento segundo o protocolo de suporte básico de vida percorrendo seis etapas: o planejamento, preparação, participação, teledebriefing, avaliação e feedback e a aprendizagem adicional, com Índice de Validade de Conteúdo de 0,96. Conclusão O design desenvolvido foi considerado válido em conteúdo para planejar e executar a telessimulação pela enfermagem e ainda ser adaptado a outros contextos educacionais. intrahospitalar intra hospitalar adulto review adotouse adotou se Construiuse Construiu etapas planejamento preparação participação teledebriefing adicional 096 0 96 0,96 educacionais 09 9 0,9 0,
Abstract Objective To construct and validate a synchronous and observational telesimulation design in nursing for care according to in-hospital basic life support protocol for adults. Methods A methodological study based on the phases of the theoretical procedure carried out through a scoping review; empirical phase developed through the telesimulated design content validity and analytical phase in which the content validity index was adopted. Results A care design was constructed according to the basic life support protocol, going through six steps: planning, preparation, participation, teledebriefing, assessment and feedback and additional learning, with a Content Validity Index of 0.96. Conclusion The developed design was considered valid in content to plan and execute telesimulation by nursing and still be adapted to other educational contexts. inhospital hospital adults review adopted steps planning preparation participation teledebriefing learning 096 0 96 0.96 contexts 09 9 0.9 0.
3.
Publicações científicas sobre direção veicular por pessoas idosas: revisão de escopo idosas
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Mourão, Danielle Félix Arruda
; Oliveira, Eveline Alves
; Ribeiro, Alice Silva Osterne
; Almeida, Paulo César de
; Oliveira, Thalis Rebouças de
; Freitas, Maria Célia de
.
Resumo Objetivo Mapear evidências científicas nacionais e internacionais sobre a condução veicular por pessoas idosas. Método Revisão de escopo baseada no manual proposto pelo Joanna Briggs Institute. Para as buscas foram acessadas as bases MEDLINE, Web of Science, Scopus, SciELO e a literatura cinzenta, por meio do Google Scholar. Resultados Dos 1.194 estudos encontrados, selecionaram-se 189 artigos submetidos aos critérios de elegibilidade. Os países precursores nas publicações foram Austrália e Estados Unidos, e o ápice das pesquisas ocorreu entre 2013 e 2014. Os participantes dos estudos eram pessoas idosas saudáveis, 63,49% (120); seguidos de 17,46% (33) com doença de Alzheimer; 11,11% (21) com Transtorno Neurocognitivo Leve; 6,88% (13) com doença de Parkinson; e 19,58% (37) com outras comorbidades. Diferentes tipos de intervenções foram identificadas nos estudos, destas, 94,02% (178) avaliaram a eficácia de instrumentos que mensuram a aptidão do motorista idoso. Conclusão Houve predominância de estudos na busca de instrumentos de avaliação que mensurassem a funcionalidade do condutor idoso. Esse fato ratifica a importância de avaliação padronizada, validada e economicamente viável que colabore na identificação do motorista em risco. Evidenciou-se a necessidade de intervenções para a prática da geriatria e gerontologia, por meio de ações para formação de equipe multidisciplinar especializada em condução veicular, de modo a adequar as diretrizes de licenciamento a fim de atender às especificidades dos condutores idosos, considerando os aspectos sociais, econômicos, políticos e educacionais, especialmente nos departamentos de trânsito brasileiro. Institute MEDLINE Science Scopus cinzenta Scholar 1194 1 194 1.19 encontrados selecionaramse selecionaram se 18 elegibilidade Unidos 201 2014 saudáveis 6349 63 49 63,49 120 (120) 1746 17 46 17,46 33 (33 Alzheimer 1111 11 11,11 21 (21 Leve 688 6 88 6,88 13 (13 Parkinson 1958 19 58 19,58 37 (37 comorbidades destas 9402 94 02 94,02 178 (178 idoso padronizada risco Evidenciouse Evidenciou gerontologia idosos sociais econômicos educacionais brasileiro 119 1.1 20 634 4 63,4 12 (120 174 17,4 3 (3 111 11,1 2 (2 68 8 6,8 (1 195 5 19,5 940 9 0 94,0 (17 1. 63, (12 17, ( 11, 6, 19, 94,
Abstract Objective To map national and international scientific evidence regarding driving by older adults. Method Scope review based on the manual proposed by the Joanna Briggs Institute. Searches were conducted in the MEDLINE, Web of Science, Scopus, SciELO databases, and grey literature through Google Scholar. Results Out of 1,194 studies identified, 189 papers meeting eligibility criteria were selected. Pioneering countries in publications were Australia and the United States, with the peak of research occurring between 2013 and 2014. Study participants included healthy older adults (63.49%, 120), followed by those with Alzheimer's disease (17.46%, 33), Mild Neurocognitive Disorder (11.11%, 21), Parkinson's disease (6.88%, 13), and other comorbidities (19.58%, 37). Various interventions were identified, with 94.02% (178) assessing the effectiveness of instruments measuring the fitness of older drivers. Conclusion There was a prevalence of studies aimed at identifying assessment tools to measure the functionality of older drivers. This underscores the importance of standardized, validated, and economically viable assessments that contribute to identifying at-risk drivers. The need for interventions in geriatrics and gerontology was evident, emphasizing the necessity for actions to establish a specialized multidisciplinary team in vehicular driving. This approach seeks to align licensing guidelines with the specific needs of older drivers, taking into account social, economic, political, and educational aspects, particularly within the Brazilian traffic departments. Institute MEDLINE Science Scopus databases Scholar 1194 1 194 1,19 identified 18 selected States 201 2014 63.49%, 6349 63 49 (63.49% 120, 120 , 120) Alzheimers Alzheimer s 17.46%, 1746 17 46 (17.46% 33, 33 33) 11.11%, 1111 11 (11.11% 21, 21 21) Parkinsons Parkinson 6.88%, 688 6 88 (6.88% 13, 13 13) 19.58%, 1958 19 58 (19.58% 37. 37 . 37) 9402 94 02 94.02 178 (178 drivers standardized validated atrisk risk evident social economic political aspects departments 119 1,1 20 63.49% 634 4 (63.49 12 17.46% 174 (17.46 3 11.11% 111 (11.11 2 6.88% 68 8 (6.88 19.58% 195 5 (19.58 940 9 0 94.0 (17 1, 63.49 (63.4 17.46 (17.4 11.11 (11.1 6.88 (6.8 19.58 (19.5 94. (1 63.4 (63. 17.4 (17. 11.1 (11. 6.8 (6. 19.5 (19. ( 63. (63 17. 11. (11 6. (6 19. (19
4.
Diretrizes Brasileiras de Medidas da Pressão Arterial Dentro e Fora do Consultório – 2023 202 20 2
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Feitosa, Audes Diogenes de Magalhães
; Barroso, Weimar Kunz Sebba
; Mion Junior, Decio
; Nobre, Fernando
; Mota-Gomes, Marco Antonio
; Jardim, Paulo Cesar Brandão Veiga
; Amodeo, Celso
; Oliveira, Adriana Camargo
; Alessi, Alexandre
; Sousa, Ana Luiza Lima
; Brandão, Andréa Araujo
; Pio-Abreu, Andrea
; Sposito, Andrei C.
; Pierin, Angela Maria Geraldo
; Paiva, Annelise Machado Gomes de
; Spinelli, Antonio Carlos de Souza
; Machado, Carlos Alberto
; Poli-de-Figueiredo, Carlos Eduardo
; Rodrigues, Cibele Isaac Saad
; Forjaz, Claudia Lucia de Moraes
; Sampaio, Diogo Pereira Santos
; Barbosa, Eduardo Costa Duarte
; Freitas, Elizabete Viana de
; Cestario, Elizabeth do Espirito Santo
; Muxfeldt, Elizabeth Silaid
; Lima Júnior, Emilton
; Campana, Erika Maria Gonçalves
; Feitosa, Fabiana Gomes Aragão Magalhães
; Consolim-Colombo, Fernanda Marciano
; Almeida, Fernando Antônio de
; Silva, Giovanio Vieira da
; Moreno Júnior, Heitor
; Finimundi, Helius Carlos
; Guimarães, Isabel Cristina Britto
; Gemelli, João Roberto
; Barreto-Filho, José Augusto Soares
; Vilela-Martin, José Fernando
; Ribeiro, José Marcio
; Yugar-Toledo, Juan Carlos
; Magalhães, Lucélia Batista Neves Cunha
; Drager, Luciano F.
; Bortolotto, Luiz Aparecido
; Alves, Marco Antonio de Melo
; Malachias, Marcus Vinícius Bolívar
; Neves, Mario Fritsch Toros
; Santos, Mayara Cedrim
; Dinamarco, Nelson
; Moreira Filho, Osni
; Passarelli Júnior, Oswaldo
; Vitorino, Priscila Valverde de Oliveira
; Miranda, Roberto Dischinger
; Bezerra, Rodrigo
; Pedrosa, Rodrigo Pinto
; Paula, Rogerio Baumgratz de
; Okawa, Rogério Toshiro Passos
; Póvoa, Rui Manuel dos Santos
; Fuchs, Sandra C.
; Lima, Sandro Gonçalves de
; Inuzuka, Sayuri
; Ferreira-Filho, Sebastião Rodrigues
; Fillho, Silvio Hock de Paffer
; Jardim, Thiago de Souza Veiga
; Guimarães Neto, Vanildo da Silva
; Koch, Vera Hermina Kalika
; Gusmão, Waléria Dantas Pereira
; Oigman, Wille
; Nadruz Junior, Wilson
.
5.
Maize Yield and Soil Penetration Resistance in Different Soil Tillage and Cover Crop Systems
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Pletsch, Fernando
; Conceição, Paulo Cesar
; Haskel, Maiara Karini
; Amadori, Caroline
; Ferreira, Daniel
; Kniess, Yana Kelly
; Guelere, Rafael Ribeiro
; Cassol, Cidimar
.
Brazilian Archives of Biology and Technology
- Journal Metrics
Abstract No-tillage (NT) is a conservation practice adopted by 60% of the Brazilian farmers. Due to unsuitable management, compaction problem reported in soils under NT has increased. The study aimed to evaluate the influence of different soil tillage and different winter cover crops in long-term on crops biomass and maize yield and on soil penetration resistance (PR), in two crop seasons. The long-term experiment is located at the UTFPR Dois Vizinhos experimental station, with a combination of five soil tillage: NT; NT chiseled up to 0.35 m deep (Jumbo), annually (NTCa) and triennially (NTCt); NT with minimum tillage chiseled up to 0.35 m deep (Terrus), annually (NTMTa) and triennially (NTMTt); and four winter cover crops: black oats, common vetch, forage radish, and a mixture of oats + vetch + radish (mix). Dry matter production of cover crops was higher in oats and the mix, and in NTMTa in both years (2021 and 2022). Soil chiseling reduces PR, however over time, an increase was observed. NT showed higher PR, especially in the 0.15-0.20 m soil layer, but it did not impact crop production. Maize yield was not influenced by cover crops or soil tillage. NT proved to be the most efficient soil management, as its performance in maize yield was similar to the others, indicating the way forward in the pursuit of a more sustainable agriculture. Notillage No (NT 60 farmers management increased longterm long term PR , (PR) seasons station 035 0 35 0.3 Jumbo, Jumbo (Jumbo) NTCa (NTCa NTCt (NTCt) Terrus, Terrus (Terrus) (NTMTa NTMTt (NTMTt) mix. mix . (mix) 2021 (202 2022. 2022 2022) time observed 0.150.20 015020 0.15 0.20 15 20 0.15-0.2 layer others agriculture 6 (PR 03 3 0. (Jumbo (NTCt (Terrus (NTMTt (mix 202 (20 150 0.150.2 01502 015 0.1 020 0.2 1 2 0.15-0. (2 0.150. 0150 01 02 0.15-0 ( 0.150 0.15-
6.
APENDIC-RADS: an ultrasound reporting system for the diagnosis of acute appendicitis APENDICRADS APENDIC RADS APENDIC-RADS
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Queiroz, Marcos Roberto Gomes de
; Jabour, Victor Arantes
; Souza Junior, José Leão de
; Paixão, Milena Ribeiro
; Silva, Paulo Savoia Dias da
; Kang, Davi Wen Wei
; Barboza, Gaby Cecilia Yupanqui Guerra
; Bourroul, Guilherme Muniz
; Lamare, Juliana Maria Haddad de
; Pontes, Irline Cordeiro de Macedo
; Pereira, Gabriela Cauper de Carvalho
; Roselli, Wanessa Rolando
; Silva, Marcelo Rocha Corrêa da
; Rahal Junior, Antonio
; Braga, Cesar Augusto Passos
; Francisco Neto, Miguel José
.
ABSTRACT Objective: Abdominal ultrasonography is widely used to evaluate suspected cases of appendicitis. Objective descriptions of the direct and indirect signs of appendicitis result in varied assessments of its likelihood. This study introduces the Appendix Imaging Reporting and Data System (APENDIC-RADS) to standardize the reporting of appendix ultrasound findings. Methods: This single-center retrospective study included consecutive patients of all ages who underwent abdominal ultrasonography for the investigation of acute appendicitis. The primary outcome was histopathological confirmation of acute appendicitis post-surgery. The imaging findings were classified into five categories: APENDIC-RADS 0, where the appendix cannot be visualized; APENDIC-RADS 1, indicating a normal appendix; APENDIC-RADS 2, describing an appendix that is likely normal but only partially visualized; APENDIC-RADS 3, appendicitis cannot be ruled out due to uncertain features and APENDIC-RADS 4, acute appendicitis. Results: A total of 747 patients were assessed for suspected acute appendicitis using ultrasonography. Of the diagnosed patients, 52% were male, primarily exhibiting symptoms such as nausea and/or vomiting (60%), right iliac fossa pain (54%), and sudden decompression in the right iliac fossa (24%). Stratification into APENDIC-RADS categories revealed a significant variation in the incidence of acute appendicitis, with incidence rates of 4.5% for category 0 and 0.7%, 2.2%, 11.5%, and 93.5% for categories 1 to 4, respectively (p<0.001). The APENDIC-RADS showed excellent discriminative ability, evidenced by an area under the receiver operating characteristic curve of 0.950 (95%CI=0.899-1). Conclusion: APENDIC-RADS categorization demonstrated excellent performance in standardizing the ultrasound-determined probability of acute appendicitis. Its implementation could improve physician communication and standardization of patient management. likelihood APENDICRADS APENDIC RADS (APENDIC-RADS Methods singlecenter single center postsurgery. postsurgery post surgery. surgery post-surgery visualized 2 3 4 Results 74 52 male andor or 60%, 60 60% , (60%) 54%, 54 54% (54%) 24%. 24 24% . (24%) 45 5 4.5 07 7 0.7% 22 2.2% 115 11 11.5% 935 93 93.5 p<0.001. p0001 p p<0.001 001 (p<0.001) ability 0950 950 0.95 95%CI=0.8991. 95CI08991 CI 95%CI=0.899 95 899 (95%CI=0.899-1) Conclusion ultrasounddetermined determined management 6 (60% (54% (24% 4. 0.7 2.2 11.5 9 93. p000 p<0.00 00 (p<0.001 095 0.9 8991 95%CI=0.8991 95CI0899 95%CI=0.89 89 (95%CI=0.899-1 (60 (54 (24 0. 2. 11. p00 p<0.0 (p<0.00 09 95CI089 95%CI=0.8 8 (95%CI=0.899- (6 (5 (2 p0 p<0. (p<0.0 95CI08 95%CI=0. (95%CI=0.899 ( p<0 (p<0. 95CI0 95%CI=0 (95%CI=0.89 p< (p<0 95CI 95%CI= (95%CI=0.8 (p< 95%CI (95%CI=0. (p (95%CI=0 (95%CI= (95%CI
7.
Coleoptera of Brazil: what we knew then and what we know now. Insights from the Catálogo Taxonômico da Fauna do Brasil Brazil now
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Caron, Edilson
; Monné, Marcela L.
; Ferreira, Vinicius S.
; Costa, Cleide
; Cupello, Mario
; Aloquio, Sergio
; Linzmeier, Adelita M.
; Vaz-de-Mello, Fernando Z.
; Leivas, Fernando W.T.
; Souza-Gonçalves, Igor
; Mermudes, José R.M.
; Almeida, Lúcia M.
; Moura, Luciano de A.
; Ferreira Júnior, Nelson
; Grossi, Paschoal C.
; Vanin, Sergio A.
; Ślipiński, Adam
; Anichtchenko, Alexander
; Newton, Alfred F.
; Sampaio, Aline
; Carelli, Allan
; Puker, Anderson
; Ferreira, André da S.
; Fernandes, André S.
; Roza, André S.
; Cline, Andrew
; Sampaio, Brunno H.L.
; Clarkson, Bruno
; Castro, Camila F. de
; Bicho, Carla de L.
; Benetti, César J.
; Ribeiro-Costa, Cibele S.
; Lopes-Andrade, Cristiano
; Manfio, Daiara
; Colpani, Daniara
; Basílio, Daniel S.
; Bená, Daniela de C.
; Pollock, Darren A.
; Souza, Diego de S.
; Rodrigues, Diego F.
; Chandler, Donald S.
; Nascimento, Elynton A. do
; Spiessberger, Erich L.
; Agrain, Federico A.
; Barbosa, Felipe F.
; Shockley, Floyd
; Nascimento, Francisco E. de L.
; Biffi, Gabriel
; Powell, Gareth S.
; Morse, Geoffrey E.
; Flores, Gustavo E.
; Escalona, Hermes
; Quintino, Hingrid Y.S.
; Rainho, Hugo L.
; Maddalena, Italo S.C.P.
; Hájek, Jiří
; McHugh, Joseph V.
; Botero, Juan P.
; Fuhrmann, Juares
; Churata-Salcedo, Julissa M.
; Vieira, Letícia M.
; Silveira, Luiz F.L. da
; Cruz, Luiza S. da
; Sekerka, Lukás
; Bologna, Marco A.
; Bevilaqua, Marcus V.O.
; Passos, Maria I.
; Chamorro, Maria L.
; Cherman, Mariana A.
; Bento, Matheus
; Gimmel, Matthew
; Segura, Melissa O.
; Ivie, Michael A.
; Thomas, Michael C.
; Monné, Miguel A.
; Lord, Nathan
; Hamada, Neusa
; Degallier, Nicolas
; Santos, Paula B. dos
; Duarte, Paulo R.M.
; Gnaspini, Pedro
; Bulirsch, Petr
; Regalin, Renato
; Leschen, Richard A.B.
; Constantin, Robert
; Corrêa, Rodrigo C.
; Gerstmeier, Roland
; Rosa, Simone P.
; Campos, Stéphanie V.N.
; Peck, Stewart B.
; Pacheco, Thaynara L.
; Polizei, Thiago T.S.
; McElrath, Thomas C.
; Grzymala, Traci L.
; Smith, Trevor R.
; Costa-Silva, Vinicius da
; Sandoval-Gómez, Vivian E.
; Sousa, Wesley O. de
; Tomaszewska, Wioletta
.
ABSTRACT In 2000, Cleide Costa published a paper presenting the state of knowledge of the Neotropical Coleopte ra, with a focus on the Brazilian fauna. Twenty-four years later, thanks to the development of the Coleoptera section of the Taxonomic Catalog of the Brazilian Fauna (CTFB - Catálogo Taxonômico da Fauna do Brasil) through the collaboration of 100 coleopterists from all over the globe, we can build on Costa’s work and present an updated overview of the state of knowledge of the beetles from Brazil. There are currently 35,699 species in 4,958 genera and 116 families known to occur in the country, including representatives of all extant suborders and superfamilies. Our data show that the Brazilian beetle fauna is the richest on the planet, concentrating 9% of the world species diversity, with some estimates accounting to up to 15% of the global total. The most diverse family in numbers of genera is Cerambycidae (1,056 genera), while in number of species it is Chrysomelidae (6,079 species). Conotrachelus Dejean, 1835 (Curculionidae) is the most species-rich genus, with 570 species. The French entomologist Maurice Pic is the author who has contributed the most to the naming of species recorded from Brazil, with 1,794 valid names in 36 families, whereas the Brazilians Ubirajara R. Martins and Maria Helena M. Galileo are the only ones among the top-ten authors to have named species in the 21st century. Currently, approximately 144 new species of Brazilian beetles are described each year, and this average is projected to increase in the next decade to 180 species per year, or about one new Brazilian beetle every two days. 2000 ra Twentyfour Twenty four later CTFB Brasil 10 globe Costas s Brazil 35699 35 699 35,69 4958 4 958 4,95 11 country superfamilies planet 9 diversity 15 total 1,056 1056 1 056 (1,05 genera, , genera) 6,079 6079 6 079 (6,07 . species) Dejean 183 Curculionidae (Curculionidae speciesrich rich genus 57 1794 794 1,79 3 R M topten top ten st century Currently 14 year 18 days 200 3569 69 35,6 495 95 4,9 1,05 105 05 (1,0 6,07 607 07 (6,0 5 179 79 1,7 20 356 35, 49 4, 1,0 0 (1, 6,0 60 (6, 17 7 1, 2 (1 6, (6 (
8.
Brazilian consensus recommendations on the diagnosis and treatment of autoimmune encephalitis in the adult and pediatric populations
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Dutra, Lívia Almeida
; Silva, Pedro Victor de Castro
; Ferreira, João Henrique Fregadolli
; Marques, Alexandre Coelho
; Toso, Fabio Fieni
; Vasconcelos, Claudia Cristina Ferreira
; Brum, Doralina Guimarães
; Pereira, Samira Luisa dos Apóstolos
; Adoni, Tarso
; Rocha, Leticia Januzi de Almeida
; Sampaio, Leticia Pereira de Brito
; Sousa, Nise Alessandra de Carvalho
; Paolilo, Renata Barbosa
; Pizzol, Angélica Dal
; Costa, Bruna Klein da
; Disserol, Caio César Diniz
; Pupe, Camila
; Valle, Daniel Almeida do
; Diniz, Denise Sisterolli
; Abrantes, Fabiano Ferreira de
; Schmidt, Felipe da Rocha
; Cendes, Fernando
; Oliveira, Francisco Tomaz Meneses de
; Martins, Gabriela Joca
; Silva, Guilherme Diogo
; Lin, Katia
; Pinto, Lécio Figueira
; Santos, Mara Lúcia Schimtz Ferreira
; Gonçalves, Marcus Vinícius Magno
; Krueger, Mariana Braatz
; Haziot, Michel Elyas Jung
; Barsottini, Orlando Graziani Povoas
; Nascimento, Osvaldo José Moreira do
; Nóbrega, Paulo Ribeiro
; Proveti, Priscilla Mara
; Castilhos, Raphael Machado do
; Daccach, Vanessa
; Glehn, Felipe von
.
Resumo Antecedentes Encefalites autoimunes (EAIs) são um grupo de doenças inflamatórias caracterizadas pela presença de anticorpos contra antígenos neuronais e gliais, que ocasionam sintomas psiquiátricos subagudos, queixas de memória e distúrbios anormais do movimento. A maioria dos pacientes é jovem, e o atraso no tratamento está associado a pior prognóstico. Objetivo Com o apoio da Academia Brasileira de Neurologia (ABN) e da Sociedade Brasileira de Neurologia Infantil (SBNI), desenvolvemos um consenso sobre o diagnóstico e o tratamento da EAIs no Brasil utilizando a metodologia Delphi. Métodos Um total de 25 especialistas, incluindo neurologistas e neurologistas infantis, foram convidados a participar. Resultados Os especialistas concordaram que os pacientes com critérios de possíveis EAIs devem ser submetidos ao rastreio de anticorpos antineuronais no soro e no líquido cefalorraquidiano (LCR) por meio das técnicas de ensaio baseado em tecidos (tissue-based assay, TBA, em inglês) e ensaio baseado em células (cell-based assay, CBA, em inglês). As crianças também devem ser submetidas ao rastreio de de anticorpo contra a glicoproteína da mielina de oligodendrócitos (anti-myelin oligodendrocyte glycoprotein, anti-MOG, em inglês). O tratamento deve ser iniciado dentro das primeiras 4 semanas dos sintomas, sendo as opções de primeira linha metilprednisolona combinada com imunoglobulina intravenosa (IGIV) ou plasmaférese. O tratamento de segunda linha inclui rituximabe e ciclofosfamida. Bortezomib e tocilizumab são opções de tratamento de terceira linha. A maioria das crises epilépticas nas EAIs são sintomáticas, e os fármacos anticrise podem ser desmamadas após a fase aguda. Em relação à encefalite antirreceptor de N-metil-D-aspartato (anti-N-methyl-D-aspartate receptor, anti-NMDAR, em inglês), os especialistas concordaram que agentes imunossupressores orais não devem ser usados. Os pacientes devem ser avaliados na fase aguda e pós-aguda mediante escalas funcionais e cognitivas, como Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), Modified Rankin Scale (mRS), e Clinical Assessment Scale in Autoimmune Encephalitis (CASE). Conclusão Esta pesquisa oferece evidências tangíveis do manejo efetivo de pacientes com EAIs no sistema de saúde Brasileiro. (EAIs gliais subagudos movimento jovem prognóstico ABN (ABN SBNI, SBNI , (SBNI) Delphi 2 infantis participar LCR (LCR tissuebased tissue based assay TBA inglês cellbased cell CBA inglês. . antimyelin anti myelin glycoprotein antiMOG, antiMOG MOG, MOG anti-MOG IGIV (IGIV plasmaférese ciclofosfamida sintomáticas NmetilDaspartato N metil D aspartato antiNmethylDaspartate methyl aspartate receptor antiNMDAR, antiNMDAR NMDAR, NMDAR anti-NMDAR inglês, usados pósaguda pós cognitivas MiniMental Mini Mental MMSE, MMSE (MMSE) MoCA, MoCA (MoCA) mRS, mRS (mRS) CASE. CASE (CASE) Brasileiro (SBNI (MMSE (MoCA (mRS (CASE
Abstract Background Autoimmune encephalitis (AIE) is a group of inflammatory diseases characterized by the presence of antibodies against neuronal and glial antigens, leading to subacute psychiatric symptoms, memory complaints, and movement disorders. The patients are predominantly young, and delays in treatment are associated with worse prognosis. Objective With the support of the Brazilian Academy of Neurology (Academia Brasileira de Neurologia, ABN) and the Brazilian Society of Child Neurology (Sociedade Brasileira de Neurologia Infantil, SBNI), a consensus on the diagnosis and treatment of AIE in Brazil was developed using the Delphi method. Methods A total of 25 panelists, including adult and child neurologists, participated in the study. Results The panelists agreed that patients fulfilling criteria for possible AIE should be screened for antineuronal antibodies in the serum and cerebrospinal fluid (CSF) using the tissue-based assay (TBA) and cell-based assay (CBA) techniques. Children should also be screened for anti-myelin oligodendrocyte glucoprotein antibodies (anti-MOG). Treatment should be started within the first 4 weeks of symptoms. The first-line option is methylprednisolone plus intravenous immunoglobulin (IVIG) or plasmapheresis, the second-line includes rituximab and/or cyclophosphamide, while third-line treatment options are bortezomib and tocilizumab. Most seizures in AIE are symptomatic, and antiseizure medications may be weaned after the acute stage. In anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis, the panelists have agreed that oral immunosuppressant agents should not be used. Patients should be evaluated at the acute and postacute stages using functional and cognitive scales, such as the Mini-Mental State Examination (MMSE), the Montreal Cognitive Assessment (MoCA), the Modified Rankin Scale (mRS), and the Clinical Assessment Scale in Autoimmune Encephalitis (CASE). Conclusion The present study provides tangible evidence for the effective management of AIE patients within the Brazilian healthcare system. (AIE antigens symptoms complaints disorders young prognosis Academia ABN Sociedade Infantil SBNI, SBNI , SBNI) method 2 neurologists CSF (CSF tissuebased tissue based TBA (TBA cellbased cell CBA (CBA techniques antimyelin anti myelin antiMOG. antiMOG MOG . (anti-MOG) firstline line IVIG (IVIG plasmapheresis secondline second andor cyclophosphamide thirdline third tocilizumab symptomatic stage antiNmethylDaspartate N methyl D aspartate antiNMDAR NMDAR (anti-NMDAR used scales MiniMental Mini Mental MMSE, MMSE (MMSE) MoCA, MoCA (MoCA) mRS, mRS (mRS) CASE. CASE (CASE) system (anti-MOG (MMSE (MoCA (mRS (CASE
9.
Curva de Aprendizagem da Mortalidade Hospitalar da Substituição da Válvula Aórtica Transcateter: Insights do Registro Nacional Brasileiro Transcateter
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Bernardi, Fernando Luiz de Melo
; Abizaid, Alexandre A.
; Brito Jr, Fábio Sândoli de
; Lemos, Pedro A.
; Siqueira, Dimytri Alexandre Alvim de
; Costa, Ricardo Alves
; Leite, Rogério Eduardo Gomes Sarmento
; Mangione, Fernanda Marinho
; Thiago, Luiz Eduardo Koenig São
; Mangione, José A.
; Lima, Valter Correia de
; Oliveira, Adriano Dourado
; Marino, Marcos Antônio
; Cardoso, Carlos José Francisco
; Caramori, Paulo R. A.
; Tumelero, Rogério
; Portela, Antenor Lages Fortes
; Prudente, Mauricio
; Henriques, Leônidas Alvarenga
; Souza, Fabio Solano
; Bezerra, Cristiano Guedes
; Prado Jr, Guy F. A.
; Freitas, Leandro Zacaris Figueiredo
; Nogueira, Ederlon Ferreira
; Meireles, George César Ximenes
; Pope, Renato Bastos
; Guerios, Enio
; Andrade, Pedro Beraldo de
; Santos, Luciano de Moura
; Marchi, Mauricio Felippi de Sá
; Fundão, Nelson Henrique Fantin
; Ribeiro, Henrique Barbosa
.
Resumo Fundamento Dados robustos sobre a curva de aprendizagem (LC) da substituição da válvula aórtica transcateter (TAVR) são escassos nos países em desenvolvimento. Objetivo Avaliar a LC da TAVR no Brasil ao longo do tempo. Métodos Analisamos dados do registro brasileiro de TAVR de 2008 a 2023. Pacientes de cada centro foram numerados cronologicamente em número sequencial de caso (NSC). A LC foi realizada usando um spline cúbico restrito ajustado para o EuroSCORE-II e o uso de próteses de nova geração. Ainda, os desfechos hospitalares foram comparados entre grupos definidos de acordo com o nível de experiência, com base no NSC: 1º ao 40º caso (experiência inicial), 41º ao 80º caso (experiência básica), 81º ao 120º caso (experiência intermediária) e 121º caso em diante (experiência alta). Análises adicionais foram conduzidas de acordo com o número de casos tratados antes de 2014 (>40 e ≤40 procedimentos). O nível de significância adotado foi p <0,05. Resultados Foram incluídos 3194 pacientes de 25 centros. A idade média foi 80,7±8,1 anos e o EuroSCORE II médio foi 7±7,1. A análise da LC demonstrou uma queda na mortalidade hospitalar ajustada após o tratamento de 40 pacientes. Um patamar de nivelamento na curva foi observado após o caso 118. A mortalidade hospitalar entre os grupos foi 8,6%, 7,7%, 5,9%, e 3,7% para experiência inicial, básica, intermediária e alta, respectivamente (p<0,001). A experiência alta foi preditora independente de mortalidade mais baixa (OR 0,57, p=0,013 vs. experiência inicial). Centros com baixo volume de casos antes de 2014 não mostraram uma redução significativa na probabilidade de morte com o ganho de experiência, enquanto centros com alto volume de casos antes de 2014 apresentaram uma melhora contínua após o caso de número 10. Conclusão Observou-se um fenômeno de LC para a mortalidade hospitalar do TAVR no Brasil. Esse efeito foi mais pronunciado em centros que trataram seus 40 primeiros casos antes de 2014 que naqueles que o fizeram após 2014. (LC (TAVR desenvolvimento tempo 200 2023 NSC. NSC . (NSC) EuroSCOREII geração Ainda º inicial , inicial) básica básica) alta. alta) 201 >40 (>4 ≤4 procedimentos. procedimentos procedimentos) 005 0 05 <0,05 319 2 80781 80 7 8 1 80,7±8, 771 7±7,1 4 118 86 6 8,6% 77 7,7% 59 5 9 5,9% 37 3 3,7 p<0,001. p0001 p<0,001 001 (p<0,001) OR 057 57 0,57 p0013 013 p=0,01 vs inicial. 10 Observouse Observou se 20 202 (NSC >4 (> ≤ 00 <0,0 31 8078 80,7±8 7±7, 11 8,6 7,7 5,9 3, p000 p<0,00 (p<0,001 0,5 p001 01 p=0,0 > ( <0, 807 80,7± 7±7 8, 7, 5, p00 p<0,0 (p<0,00 0, p=0, <0 80,7 7± p0 p<0, (p<0,0 p=0 < 80, p<0 (p<0, p= p< (p<0 (p< (p
Abstract Background Robust data on the learning curve (LC) of transcatheter aortic valve replacement (TAVR) are lacking in developing countries. Objective To assess TAVR’s LC in Brazil over time. Methods We analyzed data from the Brazilian TAVR registry from 2008 to 2023. Patients from each center were numbered chronologically in case sequence numbers (CSNs). LC was performed using restricted cubic splines adjusted for EuroSCORE-II and the use of new-generation prostheses. Also, in-hospital outcomes were compared between groups defined according to the level of experience based on the CSN: 1st to 40th (initial-experience), 41st to 80th (early-experience), 81st to 120th (intermediate-experience), and over 121st (high-experience). Additional analysis was performed grouping hospitals according to the number of cases treated before 2014 (>40 and ≤40 procedures). The level of significance adopted was <0.05. Results A total of 3,194 patients from 25 centers were included. Mean age and EuroSCORE II were 80.7±8.1 years and 7±7.1, respectively. LC analysis demonstrated a drop in adjusted in-hospital mortality after treating 40 patients. A leveling off of the curve was observed after case #118. In-hospital mortality across the groups was 8.6%, 7.7%, 5.9%, and 3.7% for initial-, early-, intermediate-, and high-experience, respectively (p<0.001). High experience independently predicted lower mortality (OR 0.57, p=0.013 vs. initial experience). Low-volume centers before 2014 showed no significant decrease in the likelihood of death with gained experience, whereas high-volume centers had a continuous improvement after case #10. Conclusion A TAVR LC phenomenon was observed for in-hospital mortality in Brazil. This effect was more pronounced in centers that treated their first 40 cases before 2014 than those that reached this milestone after 2014. (LC (TAVR countries TAVRs s time 200 2023 CSNs. CSNs . (CSNs) EuroSCOREII newgeneration new generation prostheses Also inhospital hospital CSN st th initialexperience, initialexperience , (initial-experience) earlyexperience, earlyexperience early (early-experience) intermediateexperience, intermediateexperience intermediate (intermediate-experience) highexperience. highexperience high (high-experience) 201 >40 (>4 ≤4 procedures. procedures procedures) 005 0 05 <0.05 3194 3 194 3,19 2 included 80781 80 7 8 1 80.7±8. 771 7±7.1 4 118 #118 Inhospital In 86 6 8.6% 77 7.7% 59 5 9 5.9% 37 3.7 initial, initial- early, early- intermediate, intermediate- highexperience, high-experience p<0.001. p0001 p p<0.001 001 (p<0.001) OR 057 57 0.57 p0013 013 p=0.01 vs experience. experience) Lowvolume Low volume highvolume 10 #10 20 202 (CSNs (initial-experience (early-experience (intermediate-experience (high-experience >4 (> ≤ 00 <0.0 319 19 3,1 8078 80.7±8 7±7. 11 #11 8.6 7.7 5.9 3. p000 p<0.00 (p<0.001 0.5 p001 01 p=0.0 #1 > ( <0. 31 3, 807 80.7± 7±7 8. 7. 5. p00 p<0.0 (p<0.00 0. p=0. # <0 80.7 7± p0 p<0. (p<0.0 p=0 < 80. p<0 (p<0. p= p< (p<0 (p< (p
10.
Cover Crops and Nitrogen Fertilization in Maize on the Productive Performance of Crop
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Guelere, Rafael Ribeiro
; Conceição, Paulo Cesar
; Cassol, Cidimar
; Amadori, Caroline
; Haskel, Maiara Karini
; Pletsch, Fernando
; Kniess, Yana Kelly
.
Brazilian Archives of Biology and Technology
- Journal Metrics
Abstract The use of conservation practices for sustainable agriculture production has grown in the last decades, mainly due to the no-tillage and the cover crops. The aim was to evaluate the productive performance of phytomass in three crop years with the effect of different winter cover crops and nitrogen (N) rates in succession maize. The study was carried out at the Federal Technological University of Paraná, in Dois Vizinhos, between 2020 and 2023, in a long-term experiment (2010). The treatments were a combination of three N rates applied to maize and eight winter cover crops. The annual cropping systems were buckwheat-winter cover crops-maize. The dry phytomass of buckwheat showed a significant difference between the residual N rates, but no difference to the cover crops. For the winter cover crops, mix and single oats showed a higher phytomass production, especially oats+vetch+radish, while common vetch had a lower production. Phytomass of maize was responsive to N addition, regardless of crop year; however, in a dry weather year, the cover crops showed no difference. Cumulative annual phytomass ranged from 10 to 28.6 Mg ha¯1 and was related to the N rate and the winter crop. Maize grain yield was higher after vetch and lupine and with N fertilization. Therefore, winter cover crops and N fertilization can contribute to the productive development of all the crops in the cropping system. decades notillage tillage (N Paraná Vizinhos 202 2023 longterm long term 2010. 2010 . (2010) buckwheatwinter cropsmaize. cropsmaize crops-maize oatsvetchradish radish oats+vetch+radish addition year however 1 286 28 6 28. ha1 ha ha¯ Therefore system 20 201 (2010 2 (201 (20 (2 (
11.
Reliability across content areas in progress tests assessing medical knowledge: a Brazilian cross-sectional study with implications for medical education assessments knowledge crosssectional cross sectional
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Hamamoto Filho, Pedro Tadao
; Hashimoto, Miriam
; Lima, Alba Regina de Abreu
; Diehl, Leandro Arthur
; Costa, Neide Tomimura
; Rehder, Patrícia Moretti
; Yarak, Samira
; Andrade, Maria Cristina de
; Hafner, Maria de Lourdes Marmorato Botta
; Ribeiro, Zilda Maria Tosta
; Moriguti, Júlio César
; Bicudo, Angélica Maria
.
ABSTRACT BACKGROUND: Brazilian medical schools equitably divide their medical education assessments into five content areas: internal medicine, surgery, pediatrics, obstetrics and gynecology, and public health. However, this division does not follow international patterns and may threaten the examinations’ reliability and validity. OBJECTIVE: To assess the reliability indices of the content areas of serial, cross-institutional progress test examinations. DESIGN AND SETTINGS: This was an analytical, observational, and cross-sectional study conducted at nine public medical schools (mainly from the state of São Paulo) with progress test examinations conducted between 2017 and 2023. METHODS: The examinations covered the areas of basic sciences, internal medicine, surgery, pediatrics, obstetrics and gynecology, and public health. We calculated reliability indices using Cronbach’s α, which indicates the internal consistency of a test. We used simple linear regressions to analyze temporal trends. RESULTS: The results showed that the Cronbach’s α for basic sciences and internal medicine presented lower values, whereas gynecology, obstetrics, and public health presented higher values. After changes in the number of items and the exclusion of basic sciences as a separate content area, internal medicine ranked highest in 2023. Individually, all content areas except pediatrics remained stable over time. CONCLUSIONS: Maintaining an equitable division in assessment content may lead to suboptimal results in terms of assessment reliability, especially for internal medicine. Therefore, content sampling of medical knowledge for general assessments should be reappraised. BACKGROUND surgery gynecology However validity OBJECTIVE serial crossinstitutional cross institutional SETTINGS analytical observational crosssectional sectional mainly Paulo 201 2023 METHODS Cronbachs Cronbach s trends RESULTS values area Individually time CONCLUSIONS Therefore reappraised 20 202 2
12.
Deficiência de Testosterona em Homens Hipertensos: Prevalência e Fatores Associados Hipertensos
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Negretto, Leandra Analia Freitas
; Rassi, Nelson
; Soares, Leonardo Ribeiro
; Saraiva, Amanda Bueno Carvalho
; Teixeira, Maria Emília Figueiredo
; Santos, Luciana da Ressurreição
; Souza, Ana Luiza Lima
; Jardim, Paulo Cesar B. Veiga
; Barroso de Souza, Weimar Kunz Sebba
; Jardim, Thiago de Souza Veiga
.
Resumo Fundamento: A deficiência de testosterona (DT) é uma condição prevalente em nosso meio e ainda muito negligenciada. A hipertensão arterial (HA) é um de seus possíveis fatores associados. Objetivos: Determinar a prevalência de DT em uma população masculina hipertensa e os fatores associados à sua ocorrência, como idade, tempo de diagnóstico de HA, número de classes de anti-hipertensivos, índice de massa corporal (IMC), diabetes, dislipidemia, doença renal crônica (DRC), sintomas positivos de DT (questionário ADAM positivo) e uso de espironolactona. Métodos: Estudo transversal com aplicação do questionário ADAM, e avaliação de dados bioquímicos, clínicos e antropométricos. Os pacientes foram estratificados em grupos de DT e testosterona normal. As variáveis categóricas foram comparadas pelo teste do qui-quadrado e as variáveis contínuas pelo teste de Mann-Witney; as variáveis com significância (p<0,05) foram submetidas à regressão linear multivariada. Resultados: A prevalência de DT foi de 26,8%. Houve associação entre DT e IMC (p=0,0007), mas não houve com idade (p=0,0520), tempo de diagnóstico de HA (p=0,1418), número de classes de anti-hipertensivos (p=0,0732), diabetes (p=0,1112); dislipidemia (p=0,3888); presença de DRC (p=0,3321); uso de espironolactona (p=0,3546) e questionário ADAM positivo (p=0,2483). Conclusões: A prevalência de DT foi alta e houve associação positiva com IMC. A testosterona total (TT) declinou 8,44 ng/dL com o aumento de 1 kg/m2 no IMC e caiu 3,79 ng/dL com o avanço em um ano na idade. Fundamento (DT negligenciada (HA Objetivos ocorrência antihipertensivos, antihipertensivos anti hipertensivos, hipertensivos IMC, , (IMC) DRC, (DRC) Métodos bioquímicos antropométricos normal quiquadrado qui quadrado MannWitney Mann Witney Mann-Witney p<0,05 p005 p 0 05 (p<0,05 multivariada Resultados 268 26 8 26,8% p=0,0007, p00007 p=0,0007 0007 (p=0,0007) p=0,0520, p00520 p=0,0520 0520 (p=0,0520) p=0,1418, p01418 p=0,1418 1418 (p=0,1418) p=0,0732, p00732 p=0,0732 0732 (p=0,0732) p=0,1112 p01112 1112 (p=0,1112) p=0,3888 p03888 3888 (p=0,3888) p=0,3321 p03321 3321 (p=0,3321) p=0,3546 p03546 3546 (p=0,3546 p=0,2483. p02483 p=0,2483 . 2483 (p=0,2483) Conclusões TT (TT 844 44 8,4 ngdL ng dL kgm2 kgm kg m2 m kg/m 379 3 79 3,7 (IMC (DRC p<0,0 p00 (p<0,0 2 26,8 p0000 p=0,000 000 (p=0,0007 p0052 p=0,052 052 (p=0,0520 p0141 p=0,141 141 (p=0,1418 p0073 p=0,073 073 (p=0,0732 p=0,111 p0111 111 (p=0,1112 p=0,388 p0388 388 (p=0,3888 p=0,332 p0332 332 (p=0,3321 p=0,354 p0354 354 (p=0,354 p0248 p=0,248 248 (p=0,2483 84 4 8, 37 7 3, p<0, p0 (p<0, 26, p000 p=0,00 00 (p=0,000 p=0,05 (p=0,052 p014 p=0,14 14 (p=0,141 p007 p=0,07 07 (p=0,073 p=0,11 p011 11 (p=0,111 p=0,38 p038 38 (p=0,388 p=0,33 p033 33 (p=0,332 p=0,35 p035 35 (p=0,35 p024 p=0,24 24 (p=0,248 p<0 (p<0 p=0,0 (p=0,00 (p=0,05 p01 p=0,1 (p=0,14 (p=0,07 (p=0,11 p=0,3 p03 (p=0,38 (p=0,33 (p=0,3 p02 p=0,2 (p=0,24 p< (p< p=0, (p=0,0 (p=0,1 (p=0, (p=0,2 (p p=0 (p=0 p= (p=
Abstract Background: Testosterone deficiency (TD) is a prevalent condition in our midst and still very neglected. Arterial hypertension (AH) is one of the possible associated factors. Objectives: To determine the prevalence of TD in a hypertensive male population and the factors associated with its occurrence, such as age, time since hypertension diagnosis, number of antihypertensive classes, body mass index (BMI), diabetes, dyslipidemia, chronic kidney disease (CKD), positive symptoms of TD (positive ADAM questionnaire) and use of spironolactone. Methods: Cross-sectional study with administration of the ADAM questionnaire, assessment of biochemical, clinical, and anthropometric data. Patients were stratified into DT and normal testosterone groups. Categorical variables were compared using the chi-squared test and continuous variables using the Mann-Witney test; variables with significance (p<0,05) were analyzed by multivariable linear regression. Results: The prevalence of TD was 26.36%. There was an association between TD and body mass index (BMI) (p=0.0007) but there was no association with age (p=0.0520), time of hypertension diagnosis (p=0.1418), number of classes of antihypertensive drugs (p=0.732), diabetes (p=0.1112); dyslipidemia (p=0.3888); CKD (p=0.3321); use of spironolactone (p=0.3546) or positive ADAM questionnaire (p=0.2483). Conclusions: TD was highly prevalent and positively associated with BMI. Total testosterone (TT) declined by 8.44ng/dL with a one unit increase in BMI and dropped by 3.79ng/dL with a one-year increase in age. Background (TD neglected AH (AH Objectives occurrence BMI, , CKD, (CKD) Methods Crosssectional Cross sectional biochemical clinical data groups chisquared chi squared MannWitney Mann Witney p<0,05 p005 p 0 05 (p<0,05 regression Results 2636 26 36 26.36% (BMI p=0.0007 p00007 0007 (p=0.0007 p=0.0520, p00520 p=0.0520 0520 (p=0.0520) p=0.1418, p01418 p=0.1418 1418 (p=0.1418) p=0.732, p0732 p=0.732 732 (p=0.732) p=0.1112 p01112 1112 (p=0.1112) p=0.3888 p03888 3888 (p=0.3888) p=0.3321 p03321 3321 (p=0.3321) p=0.3546 p03546 3546 (p=0.3546 p=0.2483. p02483 p=0.2483 . 2483 (p=0.2483) Conclusions TT (TT 844ngdL ngdL 8 44ng dL ng 379ngdL 3 79ng oneyear year (CKD p<0,0 p00 (p<0,0 263 2 26.36 p=0.000 p0000 000 (p=0.000 p0052 p=0.052 052 (p=0.0520 p0141 p=0.141 141 (p=0.1418 p073 p=0.73 73 (p=0.732 p=0.111 p0111 111 (p=0.1112 p=0.388 p0388 388 (p=0.3888 p=0.332 p0332 332 (p=0.3321 p=0.354 p0354 354 (p=0.354 p0248 p=0.248 248 (p=0.2483 p<0, p0 (p<0, 26.3 p=0.00 p000 00 (p=0.00 p=0.05 (p=0.052 p014 p=0.14 14 (p=0.141 p07 p=0.7 7 (p=0.73 p=0.11 p011 11 (p=0.111 p=0.38 p038 38 (p=0.388 p=0.33 p033 33 (p=0.332 p=0.35 p035 35 (p=0.35 p024 p=0.24 24 (p=0.248 p<0 (p<0 26. p=0.0 (p=0.0 (p=0.05 p01 p=0.1 1 (p=0.14 p=0. (p=0.7 (p=0.11 p=0.3 p03 (p=0.38 (p=0.33 (p=0.3 p02 p=0.2 (p=0.24 p< (p< (p=0. (p=0.1 p=0 (p=0.2 (p (p=0 p= (p=
13.
VATICAN (Ventilator-Associated Tracheobronchitis Initiative to Conduct Antibiotic Evaluation): protocol for a multicenter randomized open-label trial of watchful waiting versus antimicrobial therapy for ventilator-associated tracheobronchitis VentilatorAssociated Ventilator Associated Evaluation Evaluation) openlabel open label ventilatorassociated ventilator associated
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Tomazini, Bruno Martins
; Besen, Bruno Adler Maccagnan Pinheiro
; Dietrich, Camila
; Gandara, Ana Paula Rossi
; Silva, Debora Patrícia
; Pinheiro, Carla Cristina Gomes
; Luz, Mariane Nascimento
; Mattos, Renata Rodrigues de
; Reis, Luiz Fernando Lima
; Roepke, Roberta Muriel Longo
; Duarte, Carlos Sérgio Luna Gomes
; Nassar Júnior, Antônio Paulo
; Veiga, Viviane Cordeiro
; Arns, Beatriz
; Nascimento, Giovanna Marssola
; Pereira, Adriano José
; Cavalcanti, Alexandre Biasi
; Machado, Flávia Ribeiro
; Azevedo, Luciano Cesar Pontes
.
RESUMO Contexto A traqueobronquite associada ao ventilador é uma condição comum entre pacientes ventilados invasivamente em unidades de terapia intensiva, para a qual se desconhece atualmente a melhor estratégia de tratamento. Desenhamos o estudo VATICAN (Ventilator-Associated Tracheobronchitis Initiative to Conduct Antibiotic Evaluation) para avaliar se uma estratégia de tratamento antibiótico de espera vigilante não é inferior ao tratamento antibiótico de rotina para traqueobronquite associada ao ventilador em relação aos dias sem ventilador mecânico. Métodos O VATICAN é um estudo randomizado, controlado, aberto e multicêntrico de não inferioridade. Os pacientes com suspeita de traqueobronquite associada ao ventilador sem evidência de pneumonia associada ao ventilador ou instabilidade hemodinâmica devido a uma provável infecção serão designados para uma estratégia de espera vigilante, sem administração profilática de antimicrobianos contra traqueobronquite associada ao ventilador e prescrição de antimicrobianos somente em casos de pneumonia associada ao ventilador, sepse ou choque séptico, ou outro diagnóstico infeccioso, ou para uma estratégia de tratamento antimicrobiano de rotina por 7 dias. O desfecho primário será o número de dias sem ventilador mecânico em 28 dias, e um desfecho secundário importante será a sobrevida sem pneumonia associada ao ventilador. Por meio de uma estrutura de intenção de tratar com análise de sensibilidade por protocolo, a análise do desfecho primário abordará a não inferioridade com margem de 20%, o que se traduz em uma diferença de 1,5 dia sem ventilador. Outras análises seguirão uma estrutura de análise de superioridade. Conclusão O VATICAN seguirá todos os padrões éticos nacionais e internacionais. O objetivo é publicar o estudo em um periódico geral de alta visibilidade e apresentá-lo em conferências de cuidados intensivos e doenças infecciosas para divulgação. Estes resultados provavelmente serão imediatamente aplicáveis à beira do leito após a conclusão do estudo e fornecerão informações com baixo risco de viés para o desenvolvimento de diretrizes. intensiva VentilatorAssociated Ventilator Associated Evaluation randomizado controlado séptico infeccioso 2 protocolo 20 20% 15 1 5 1, superioridade internacionais apresentálo apresentá lo divulgação diretrizes
ABSTRACT Background Ventilator-associated tracheobronchitis is a common condition among invasively ventilated patients in intensive care units, for which the best treatment strategy is currently unknown. We designed the VATICAN (Ventilator-Associated Tracheobronchitis Initiative to Conduct Antibiotic Evaluation) trial to assess whether a watchful waiting antibiotic treatment strategy is noninferior to routine antibiotic treatment for ventilator-associated tracheobronchitis regarding days free of mechanical ventilation. Methods VATICAN is a randomized, controlled, open-label, multicenter noninferiority trial. Patients with suspected ventilator-associated tracheobronchitis without evidence of ventilator-associated pneumonia or hemodynamic instability due to probable infection will be assigned to either a watchful waiting strategy, without antimicrobial administration for ventilator-associated tracheobronchitis and prescription of antimicrobials only in cases of ventilator-associated pneumonia, sepsis or septic shock, or another infectious diagnosis, or to a routine antimicrobial treatment strategy for seven days. The primary outcome will be mechanical ventilation-free days at 28 days, and a key secondary outcome will be ventilator-associated pneumonia-free survival. Through an intention-to-treat framework with a per-protocol sensitivity analysis, the primary outcome analysis will address noninferiority with a 20% margin, which translates to a 1.5 difference in ventilator-free days. Other analyses will follow a superiority analysis framework. Conclusion The VATICAN trial will follow all national and international ethical standards. We aim to publish the trial in a high-visibility general journal and present it at critical care and infectious disease conferences for dissemination. These results will likely be immediately applicable to the bedside upon trial completion and will provide information with a low risk of bias for guideline development. Ventilatorassociated Ventilator associated units unknown VentilatorAssociated Associated Evaluation ventilatorassociated ventilator ventilation randomized controlled openlabel, openlabel open label, label open-label shock diagnosis ventilationfree 2 pneumoniafree survival intentiontotreat intention treat perprotocol per protocol 20 margin 15 1 5 1. ventilatorfree standards highvisibility high visibility dissemination development
14.
Catálogo Taxonômico da Fauna do Brasil: Setting the baseline knowledge on the animal diversity in Brazil Brasil
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Boeger, Walter A.
; Valim, Michel P.
; Zaher, Hussam
; Rafael, José A.
; Forzza, Rafaela C.
; Percequillo, Alexandre R.
; Serejo, Cristiana S.
; Garraffoni, André R.S.
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; Slipinski, Adam
; Linzmeier, Adelita M.
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; Chagas Júnior, Amazonas
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; Almeida, Ana C.S.
; Peronti, Ana L.B.G.
; Henriques-Oliveira, Ana L.
; Prudente, Ana L.
; Tourinho, Ana L.
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; Carmignotto, Ana P.
; Wengrat, Ana P.G. da Silva
; Dornellas, Ana P.S.
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; Puker, Anderson
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; Ferreira, André da S.
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; Brito, Ayrton do R.
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; Bellini, Bruno C.
; Clarkson, Bruno
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; Baêta, Délio
; Ferreira, Denise N.M.
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; Souza, Diego de S.
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; Gallardo, Fabiana
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; Mantellato, Fernando
; Vaz-de-Mello, Fernando Z.
; Gudin, Filipe M.
; Albuquerque, Flávio
; Molina, Flavio B.
; Passos, Flávio D.
; Shockley, Floyd W.
; Pinheiro, Francielly F.
; Mello, Francisco de A.G. de
; Nascimento, Francisco E. de L.
; Franco, Francisco L.
; Oliveira, Francisco L. de
; Melo, Francisco T. de V.
; Quijano, Freddy R.B.
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; Biffi, Gabriel
; Queiroz, Gabriel C.
; Bizarro, Gabriel L.
; Hrycyna, Gabriela
; Leviski, Gabriela
; Powell, Gareth S.
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; Morse, Geoffrey E.
; Brown, George
; Mattox, George M.T.
; Zimbrão, Geraldo
; Carvalho, Gervásio S.
; Miranda, Gil F.G.
; Moraes, Gilberto J. de
; Lourido, Gilcélia M.
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; Moreira, Gilson R.P.
; Montingelli, Giovanna G.
; Maurício, Giovanni N.
; Marconato, Gláucia
; Lopez, Guilherme E.L.
; Silva, Guilherme L. da
; Muricy, Guilherme
; Brito, Guilherme R.R.
; Garbino, Guilherme S.T.
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; Graciolli, Gustavo
; Libardi, Gustavo S.
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; Prando, Jadila S.
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; Souza, Wesley de O.
; Colombo, Wesley D.
; Tomaszewska, Wioletta
; Wosiacki, Wolmar B.
; Ovando, Ximena M.C.
; Leite, Yuri L.R.
.
ABSTRACT The limited temporal completeness and taxonomic accuracy of species lists, made available in a traditional manner in scientific publications, has always represented a problem. These lists are invariably limited to a few taxonomic groups and do not represent up-to-date knowledge of all species and classifications. In this context, the Brazilian megadiverse fauna is no exception, and the Catálogo Taxonômico da Fauna do Brasil (CTFB) (http://fauna.jbrj.gov.br/), made public in 2015, represents a database on biodiversity anchored on a list of valid and expertly recognized scientific names of animals in Brazil. The CTFB is updated in near real time by a team of more than 800 specialists. By January 1, 2024, the CTFB compiled 133,691 nominal species, with 125,138 that were considered valid. Most of the valid species were arthropods (82.3%, with more than 102,000 species) and chordates (7.69%, with over 11,000 species). These taxa were followed by a cluster composed of Mollusca (3,567 species), Platyhelminthes (2,292 species), Annelida (1,833 species), and Nematoda (1,447 species). All remaining groups had less than 1,000 species reported in Brazil, with Cnidaria (831 species), Porifera (628 species), Rotifera (606 species), and Bryozoa (520 species) representing those with more than 500 species. Analysis of the CTFB database can facilitate and direct efforts towards the discovery of new species in Brazil, but it is also fundamental in providing the best available list of valid nominal species to users, including those in science, health, conservation efforts, and any initiative involving animals. The importance of the CTFB is evidenced by the elevated number of citations in the scientific literature in diverse areas of biology, law, anthropology, education, forensic science, and veterinary science, among others. publications problem uptodate up date classifications context exception (CTFB http//fauna.jbrj.gov.br/, httpfaunajbrjgovbr http //fauna.jbrj.gov.br/ , jbrj gov br (http://fauna.jbrj.gov.br/) 2015 Brazil 80 specialists 1 2024 133691 133 691 133,69 125138 125 138 125,13 82.3%, 823 82 3 (82.3% 102000 102 000 102,00 7.69%, 769 7 69 (7.69% 11000 11 11,00 . 3,567 3567 567 (3,56 2,292 2292 2 292 (2,29 1,833 1833 833 (1,83 1,447 1447 447 (1,44 1000 1,00 831 (83 628 (62 606 (60 520 (52 50 users science health biology law anthropology education others http//fauna.jbrj.gov.br/ faunajbrjgovbr //fauna.jbrj.gov.br (http://fauna.jbrj.gov.br/ 201 8 202 13369 13 133,6 12513 12 125,1 82.3% (82.3 10200 10 00 102,0 7.69% 76 6 (7.69 1100 11,0 3,56 356 56 (3,5 2,29 229 29 (2,2 1,83 183 83 (1,8 1,44 144 44 (1,4 100 1,0 (8 62 (6 60 52 (5 5 http//fauna.jbrj.gov.br (http://fauna.jbrj.gov.br 20 1336 133, 1251 125, 82.3 (82. 1020 0 102, 7.69 (7.6 110 11, 3,5 35 (3, 2,2 22 (2, 1,8 18 (1, 1,4 14 4 ( 82. (82 7.6 (7. 3, (3 2, (2 (1 7. (7
15.
Vaccination coverage and factors associated with incomplete polio vaccine schedule in children born in 2017-2018, in state capitals and interior region municipalities of Northeast Brazil 20172018, 20172018 2017 2018, 2018 2017-2018 2017201 201 2017-201 201720 20 2017-20 20172 2 2017-2 2017-
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Ramos Jr., Alberto Novaes
; Saavedra, Ramon da Costa
; Maciel, Adjoane Mauricio Silva
; Ferreira, Anderson Fuentes
; Silva, Taynara Lais
; Lima, Luisa Helena de Oliveira
; Domingues, Carla Magda Allan Santos
; Barbosa, Jaqueline Caracas
; Kerr, Ligia Regina Franco Sansigolo
; França, Ana Paula
; Silva, Pallysson Paulo da
; Teixeira, Maria da Gloria
; Moraes, José Cássio de
; Silva, Adriana Ilha da
; Ramos Jr., Alberto Novaes
; França, Ana Paula
; Oliveira, Andrea de Nazaré Marvão
; Boing, Antonio Fernando
; Domingues, Carla Magda Allan Santos
; Oliveira, Consuelo Silva de
; Maciel, Ethel Leonor Noia
; Guibu, Ione Aquemi
; Mirabal, Isabelle Ribeiro Barbosa
; Barbosa, Jaqueline Caracas
; Lima, Jaqueline Costa
; Moraes, José Cássio de
; Luhm, Karin Regina
; Caetano, Karlla Antonieta Amorim
; Lima, Luisa Helena de Oliveira
; Antunes, Maria Bernadete de Cerqueira
; Teixeira, Maria da Gloria
; Teixeira, Maria Denise de Castro
; Borges, Maria Fernanda de Sousa Oliveira
; Queiroz, Rejane Christine de Sousa
; Gurgel, Ricardo Queiroz
; Barata, Rita Barradas
; Azevedo, Roberta Nogueira Calandrini de
; Oliveira, Sandra Maria do Valle Leone de
; Teles, Sheila Araújo
; Gama, Silvana Granado Nogueira da
; Mengue, Sotero Serrate
; Simões, Taynãna César
; Nascimento, Valdir
; Araújo, Wildo Navegantes de
.
RESUMO Objetivo Analisar a cobertura vacinal e os fatores associados ao esquema incompleto das vacinas contra a poliomielite em coorte de nascidos vivos de 2017-2018, em capitais e municípios do interior do Nordeste brasileiro. Métodos Inquérito domiciliar em crianças com idade ≤ 24 meses, entre 2020 e 2022. Estimaram-se a cobertura vacinal, a taxa de abandono e fatores associados ao esquema de vacinação incompleto, analisados pela razão de chances (odds ratio, OR) e intervalos de confiança de 95% (IC95%). Resultados Em 12.137 crianças, a cobertura vacinal (quatro doses) foi de 80,9% (IC95% 78,4;83,1); 8,4% não eram vacinadas. Não possuir caderneta de vacinação (OR = 14,05; IC95% 8,54;23,12) e uso de serviço privado (OR = 1,46; IC95% 1,23;1,74) estiveram associados à vacinação incompleta. Taxas de abandono mais altas foram observadas na dose de reforço, principalmente no estrato alto. Conclusão Observaram-se baixas coberturas, redução no seguimento das doses e elevadas taxas de abandono para vacinas contra a poliomielite nas áreas estudadas. 20172018, 20172018 2017 2018, 2018 2017-2018 brasileiro 2 meses 202 2022 Estimaramse Estimaram se odds ratio OR 95 IC95%. IC95 IC . (IC95%) 12137 12 137 12.13 quatro 809 80 9 80,9 (IC95 78,483,1 784831 78,4 83,1 78 4 83 1 78,4;83,1) 84 8 8,4 vacinadas 14,05 1405 14 05 8,5423,12 8542312 8,54 23,12 54 23 8,54;23,12 1,46 146 46 1,231,74 123174 1,23 1,74 74 1,23;1,74 incompleta reforço alto Observaramse Observaram coberturas estudadas 2017201 201 2017-201 20 IC9 1213 13 12.1 80, (IC9 483 78,483, 78483 784 78, 831 83, 7 78,4;83,1 8, 14,0 140 0 5423 8,5423,1 854231 854 8,5 2312 23,1 5 8,54;23,1 1,4 231 1,231,7 12317 123 1,2 174 1,7 1,23;1,7 201720 2017-20 121 12. (IC 48 78,483 7848 78,4;83, 14, 542 8,5423, 85423 85 23, 8,54;23, 1, 1,231, 1231 17 1,23;1, 20172 2017-2 78,48 78,4;83 8,5423 8542 8,54;23 1,231 1,23;1 2017- 78,4;8 8,542 8,54;2 1,23; 78,4; 8,54;
ABSTRACT Objective To analyse vaccination coverage and factors associated with incomplete polio vaccination in a cohort of children born in 2017-2018, in state capitals and interior region municipalities of Northeast Brazil. Methods Household survey of children aged ≤24 months conducted between 2020 and 2022. Vaccination coverage and dropout rates were estimated, as well as factors associated with incomplete vaccination, analyzed by calculating odds ratios (OR) and 95% confidence intervals (95%CI). Results : Among 12,137 children, vaccination coverage (4 doses) was 80.9% (95%CI 78.4;83.1); 8.4% were not vaccinated. Not having a vaccination card (OR=18.06; 95%CI 10.01;32.61) and use of private services (OR=1.46; 95%CI 1.23;1.74) were associated with incomplete vaccination. Higher dropout rates were found for the booster dose, especially in the highest stratum. Conclusion Low vaccination coverage, poor dose follow-up and high dropout rates were found for polio vaccines in the areas studied. 20172018, 20172018 2017 2018, 2018 2017-2018 Brazil 24 ≤2 202 2022 estimated OR (OR 95 95%CI. 95CI CI . (95%CI) 12137 12 137 12,13 4 ( doses 809 80 9 80.9 78.483.1 784831 78.4 83.1 78 83 1 78.4;83.1) 84 8 8.4 vaccinated OR=18.06 OR1806 18 06 (OR=18.06 10.0132.61 10013261 10.01 32.61 10 01 32 61 10.01;32.61 OR=1.46 OR146 46 (OR=1.46 1.231.74 123174 1.23 1.74 23 74 1.23;1.74 stratum followup follow up studied 2017201 201 2017-201 2 ≤ 20 1213 13 12,1 80. 483 78.483. 78483 784 78. 831 83. 7 78.4;83.1 8. OR=18.0 OR180 0 (OR=18.0 0132 10.0132.6 1001326 1001 10.0 3261 32.6 3 6 10.01;32.6 OR=1.4 OR14 (OR=1.4 231 1.231.7 12317 123 1.2 174 1.7 1.23;1.7 201720 2017-20 121 12, 48 78.483 7848 78.4;83. OR=18. OR18 (OR=18. 013 10.0132. 100132 100 10. 326 32. 10.01;32. OR=1. OR1 (OR=1. 1.231. 1231 1. 17 1.23;1. 20172 2017-2 78.48 78.4;83 OR=18 (OR=18 10.0132 10013 10.01;32 OR=1 (OR=1 1.231 1.23;1 2017- 78.4;8 10.013 10.01;3 OR= (OR= 1.23; 78.4; 10.01;
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