Abstract It aimed to analyze how professionals from an intersectoral service network develop care actions for adolescents with suicidal and self-injurious behaviors. This is a descriptive and exploratory study with a qualitative approach, carried out through notes in the field diary and semi-structured interviews with 22 professionals linked to social assistance, education and health services in a large municipality in northeastern Brazil. Data collection took place from August to September 2021. The speeches were subjected to content analysis in the inductive thematic modality, with support from the Nvivo 11 Pro software. Given this, two categories emerged: intersectoral network care strategies and weaknesses in care. Professionals perceive adolescents as subjects who need support for their psychological suffering. In this way, they develop, as the main care strategies, reception and prevention activities, on a punctual basis. However, the care network appears to be insufficient, due to the scarcity of child and youth policies and specialized services, in addition to difficulties in practicing intersectorality. It is concluded that the care offered to adolescents is fragile and requires the strengthening of transversal public policies, expansion of primary/specialized services and intersectoral work.

Resumo Objetivou-se analisar como os profissionais de uma rede de serviços intersetoriais desenvolvem ações de cuidado aos adolescentes com comportamentos suicidas e autolesivos. Trata-se de um estudo descritivo e exploratório de abordagem qualitativa, realizado através de anotações no diário de campo e entrevistas semiestruturadas com 22 profissionais vinculados a serviços da assistência social, educação e saúde de um município de grande porte do nordeste brasileiro. A coleta de dados ocorreu no período de agosto a setembro de 2021. Os discursos foram submetidos à análise de conteúdo na modalidade temática indutiva, com suporte do software Nvivo 11 Pro. Diante disso, duas categorias emergiram: estratégias de cuidado da rede intersetorial e fragilidades no cuidado. Os profissionais percebem os adolescentes como sujeitos que necessitam de suporte para o sofrimento psíquico apresentado. Deste modo desenvolvem, como principais estratégias de cuidado, o acolhimento e as atividades de prevenção, estas de modo pontual. Contudo, a rede de cuidados mostra-se insuficiente, devido à escassez de políticas infantojuvenis e serviços especializados, além de dificuldades na prática da intersetorialidade. Conclui-se que o cuidado ofertado aos adolescentes é fragilizado e necessita do fortalecimento de políticas públicas transversais, ampliação dos serviços primários/especializados e do trabalho intersetorial.

The potential of four commercial clones of unripe acerola fruit was investigated regarding a source of nutraceuticals and functional foods for industrial use. The chemical profiling of the BRS 235-Apodi, BRS 236-Cereja, BRS 237-Roxinha, and BRS 238-Frutacor clones was determined by the ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-QTOF/MS-MS) technique coupled to multivariate statistical analysis, which were then correlated to ABTS•+ radical capture (2,2’-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) and ferric reducing antioxidant power (FRAP) assays in order to measure the antioxidant capacity. A total of 24 bioactive compounds were identified, including high amounts of quercetin-O-hexoside, astilbin, and apigenin, which were correlated to three clones (BRS 235, BRS 237, and BRS 238). On the other hand, the BRS 236 clone presented high contents of ascorbic acid, iso-ascorbic acid, citric acid, procyanidin B trimer, rutin, phenolic compounds, and antioxidant activity. These compounds were additionally found to be strongly associated with the antioxidant capacity of unripe acerola fruits. Therefore, the present study revealed that BRS 236 is a promising clone as an antioxidant source to be used as a functional food or ingredient. use 235Apodi, 235Apodi Apodi 235 Apodi, 235-Apodi 236Cereja, 236Cereja Cereja Cereja, 236-Cereja 237Roxinha, 237Roxinha Roxinha 237 Roxinha, 237-Roxinha 238Frutacor Frutacor 238 ultrahigh ultra chromatographyquadrupole chromatography quadrupole timeofflight time flight UPLCQTOF/MSMS UPLCQTOFMSMS UPLC QTOF/MS MS QTOF (UPLC-QTOF/MS-MS analysis ABTS ABTS• 2,2azinobis3ethylbenzothiazoline6sulfonic 22azinobis3ethylbenzothiazoline6sulfonic azinobisethylbenzothiazolinesulfonic 2,2 azino bis 3 ethylbenzothiazoline 6 sulfonic 2 acid FRAP (FRAP identified quercetinOhexoside, quercetinOhexoside quercetin O hexoside, hexoside quercetin-O-hexoside astilbin apigenin 238. . 238) hand 23 isoascorbic iso trimer rutin activity fruits Therefore ingredient UPLCQTOF MSMS QTOFMS 2azinobis3ethylbenzothiazoline6sulfonic azinobis 22 2,

RESUMO Modelos de formação de atletas primam pela ampliação de experiências esportivas, incluindo os eventos esportivos. Assume-se que a variabilidade de propostas incute na vivência de situações paradoxais, importantes na permanência no esporte e/ou vida ativa. Este trabalho discute a percepção da experiência vivida em dois eventos de ginástica para todos com distintos vieses: um com caráter competitivo e outro com caráter demonstrativo. Protagonizaram o estudo 29 crianças participantes de um projeto de extensão universitária. Para a coleta de dados, realizaram-se 8 Grupos Focais, sendo utilizada a Análise Temática. Diários de campo e texto reflexivo do mediador dos GF foram considerados para a triangulação dos dados. Dois eixos foram evidenciados em ambos os eventos: a) aspectos intersubjetivos, cujo comprometimento, o componente estético e a ansiedade perpassaram ambos os eventos e a superação e o nervosismo tiveram maior destaque na competição; e b) inter-relações pessoais, nas quais a importância do outro/grupo foi evidente, com maior relação ao tipo de apresentação coreográfica de grupo, do que especificamente ao tipo de evento. Reconhece-se, então, o fomento a eventos de diferentes naturezas, uma vez que os praticantes de base podem presumir o alto rendimento ou a vida ativa pelo esporte. esportivas esportivos Assumese Assume se paradoxais eou vieses demonstrativo 2 universitária dados realizaramse realizaram Focais Temática intersubjetivos comprometimento competição b interrelações inter relações pessoais outrogrupo grupo evidente evento Reconhecese, Reconhecese Reconhece se, Reconhece-se então naturezas

ABSTRACT Models for athlete development have prioritized sports experiences, including events. It is assumed that the variety of events instills in the experience of paradoxical situations, important in the permanence in sport and/or active life. This article discusses the lived experience perception by children in two gymnastics for all events with different biases: one competitive and the other demonstrative. Based on qualitative research, 29 children were interviewed using Focus Groups (n=8), and data analysis using Thematic Analysis. Furthermore, field notes by 4 coaches and reflective narrative from the Focus Group interviewer were considered for triangulation. Two themes were highlighted: a. intersubjective aspects and b. interrelationships. These themes were addressed in both events to a greater or lesser extent. In item a, commitment, aesthetic components, and anxiety were in both events, but overcoming and nervousness more prominent in the competition. In item b, the importance of the other/ group was evident, mostly because of the presentation than the type of event. Recognizing the sporting bias of a practice is, therefore, promoting events of different natures, as practitioners can presume high performance or an active life through sport. experiences situations andor biases demonstrative research 2 n=8, n8 n n=8 , 8 (n=8) Analysis Furthermore triangulation highlighted b interrelationships extent commitment components competition evident event therefore natures n= (n=8 (n= (n

ABSTRACT Background: This study investigated the self-rated general health, mental health, and work absenteeism among patients with laboratory-confirmed chikungunya. Methods: Telephone interviews were conducted with 63 patients ≥22 months after infection. Results: Patients who reported (N=42) or did not report (N=21) chronic arthralgia, defined by duration ≥90 days, had different frequencies for low scores for general health (68.3% vs. 30.0%, respectively; prevalence ratio, 95% confidence interval: 2.3, 1.1-4.6), symptoms of depression (31.7% vs. 15.0%; 2.1, 0.7-6.6), symptoms of anxiety (43.9% vs. 35.0%; 1.3, 0.6-2.5), and work absenteeism (76.5% and 40.0%; 1.9, 0.9-4.2). Conclusions: Chikungunya chronic arthralgia impacts long-term health and work. Background selfrated self rated laboratoryconfirmed laboratory confirmed chikungunya Methods 6 22 ≥2 infection Results N=42 N42 N 42 (N=42 N=21 N21 21 (N=21 90 ≥9 days 68.3% 683 68 3 (68.3 vs 300 30 0 30.0% respectively ratio 95 interval 23 2 2.3 1.14.6, 1146 1.1 4.6 , 1 4 1.1-4.6) 31.7% 317 31 7 (31.7 15.0% 150 15 2.1 0.76.6, 0766 0.7 6.6 0.7-6.6) 43.9% 439 43 9 (43.9 35.0% 350 35 13 1.3 0.62.5, 0625 0.6 2.5 5 0.6-2.5) 76.5% 765 76 (76.5 40.0% 400 40 19 1.9 0.94.2. 0942 0.9 4.2 . 0.9-4.2) Conclusions longterm long term ≥ N=4 N4 (N=4 N=2 N2 (N=2 68.3 (68. 30.0 2. 14 1.14.6 114 11 1. 46 4. 1.1-4.6 31.7 (31. 15.0 0.76.6 076 07 0. 66 6. 0.7-6.6 43.9 (43. 35.0 62 0.62.5 062 06 25 0.6-2.5 76.5 (76. 40.0 94 0.94.2 094 09 0.9-4.2 N= (N= 68. (68 30. 1.14. 1.1-4. 31. (31 15. 0.76. 0.7-6. 43. (43 35. 0.62. 0.6-2. 76. (76 40. 0.94. 0.9-4. (N (6 1.14 1.1-4 (3 0.76 0.7-6 (4 0.62 0.6-2 (7 0.94 0.9-4 ( 1.1- 0.7- 0.6- 0.9-

Resumo Objetivou-se analisar como os profissionais de uma rede de serviços intersetoriais desenvolvem ações de cuidado aos adolescentes com comportamentos suicidas e autolesivos. Trata-se de um estudo descritivo e exploratório de abordagem qualitativa, realizado através de anotações no diário de campo e entrevistas semiestruturadas com 22 profissionais vinculados a serviços da assistência social, educação e saúde de um município de grande porte do nordeste brasileiro. A coleta de dados ocorreu no período de agosto a setembro de 2021. Os discursos foram submetidos à análise de conteúdo na modalidade temática indutiva, com suporte do software Nvivo 11 Pro. Diante disso, duas categorias emergiram: estratégias de cuidado da rede intersetorial e fragilidades no cuidado. Os profissionais percebem os adolescentes como sujeitos que necessitam de suporte para o sofrimento psíquico apresentado. Deste modo desenvolvem, como principais estratégias de cuidado, o acolhimento e as atividades de prevenção, estas de modo pontual. Contudo, a rede de cuidados mostra-se insuficiente, devido à escassez de políticas infantojuvenis e serviços especializados, além de dificuldades na prática da intersetorialidade. Conclui-se que o cuidado ofertado aos adolescentes é fragilizado e necessita do fortalecimento de políticas públicas transversais, ampliação dos serviços primários/especializados e do trabalho intersetorial. Objetivouse Objetivou se autolesivos Tratase Trata qualitativa 2 social brasileiro 2021 indutiva 1 Pro disso emergiram apresentado prevenção pontual Contudo mostrase mostra insuficiente especializados intersetorialidade Concluise Conclui transversais primáriosespecializados primários 202 20

Abstract It aimed to analyze how professionals from an intersectoral service network develop care actions for adolescents with suicidal and self-injurious behaviors. This is a descriptive and exploratory study with a qualitative approach, carried out through notes in the field diary and semi-structured interviews with 22 professionals linked to social assistance, education and health services in a large municipality in northeastern Brazil. Data collection took place from August to September 2021. The speeches were subjected to content analysis in the inductive thematic modality, with support from the Nvivo 11 Pro software. Given this, two categories emerged: intersectoral network care strategies and weaknesses in care. Professionals perceive adolescents as subjects who need support for their psychological suffering. In this way, they develop, as the main care strategies, reception and prevention activities, on a punctual basis. However, the care network appears to be insufficient, due to the scarcity of child and youth policies and specialized services, in addition to difficulties in practicing intersectorality. It is concluded that the care offered to adolescents is fragile and requires the strengthening of transversal public policies, expansion of primary/specialized services and intersectoral work. selfinjurious self injurious behaviors approach semistructured semi structured 2 assistance Brazil 2021 modality 1 software emerged suffering way activities basis However insufficient intersectorality primaryspecialized primary work 202 20

Resumo O gerenciamento integrado d resíduos sólidos urbanos (GIRSU) é considerado um desafio pelos municípios por diversos fatores, sendo o principal a alta demanda financeira do processo. A ineficiência na prestação desse serviço está associada à falta de entendimento sobre os diversos elementos que afetam todo o sistema de gerenciamento, dificultando a tomada de decisão pelos gestores. Desta forma, este artigo tem como objetivo identificar as barreiras que afetam a sustentabilidade financeira do GIRSU. A pesquisa bibliográfica selecionou 48 artigos nas bases Scopus e Web of Science, empregando o método Smart bibliometrics para subsidiar a análise sistemática. Os elementos foram apresentados e discutidos o potencial de influência sobre o sistema de gerenciamento de resíduos, em quais países decorrentes do nível de desenvolvimento tiveram mais trabalhos publicados na área e uma discussão sobre cada elemento apontado. Os resultados identificaram lacunas de pesquisa como a ausência de uma análise em que considere a inter-relação entre os elementos levantados, e ausência de estudos acerca dos métodos que podem ser utilizados para isso. Esse estudo fornece importantes contribuições a fim de planejar, alterar ou implementar sistemas de GIRSU nos municípios cidades, fornecendo informações sobre os elementos críticos que afetam a sustentabilidade financeira do gerenciamento dos RSU. (GIRSU fatores processo gestores forma 4 Science sistemática apontado interrelação inter relação levantados isso planejar cidades RSU

Abstract The integrated management of urban solid waste (IMUSW) is considered a challenge by cities due to several factors, the main one being the high financial demand of the process. Inefficiency in providing this service is associated with a lack of understanding about the various elements that affect the entire management system, making decision-making difficult for managers. Therefore, this article aims to identify the barriers that affect financial sustainability in IMUSW. The bibliographic research selected 48 articles in the Scopus and Web of Science databases, using the Smart bibliometrics method to support the systematic analysis. The elements were presented and discussed about the potential influence on the waste management system, in which countries due to the level of development had the most published works in the area and a discussion about each element highlighted. The results identified research gaps such as the absence of an analysis that considers the interrelationship between the elements raised, and the absence of studies on the methods that can be used for this. This study provides important contributions in order to plan, change or implement IMUSW systems in cities, providing information on the critical elements that affect the financial sustainability of USW management.. (IMUSW factors process system decisionmaking decision managers Therefore 4 databases highlighted raised plan management.

Abstract Morus nigra L., commonly known as black mulberry, is a significant plant species in the pharmaceutical and cosmetic industries. It is also considered an Unconventional Food Plant with potential applications in nutrition. The diversity of bioactive compounds present accounts for its antioxidant, anti-inflammatory, analgesic, and antitumor properties. Thus, this study aimed to analyze technological and scientific information on M. nigra by examining patent documents and scientific papers. The European Patent Office®, the National Institute of Industrial Property®, and Scopus® were utilized as research sources, employing the search terms “Morus nigra” for the former two and “Morus nigra” and “food” for the latter. A total of 210 documents were validated for the research. China leads in patent applications (44%), while Turkey leads in scientific publications (30%). Patents are concentrated in cosmetics, pharmaceuticals, food, and beverages, while scientific publications in the areas of Agriculture and Biological Sciences, Chemistry and Biochemistry, Genetics and Molecular Biology. The global blackberry trade is on the rise, attracting significant interest from multinational companies. Therefore, academic research and technological innovation must keep pace with market demand, given the promising use of black mulberry. L L. mulberry industries nutrition antioxidant antiinflammatory, antiinflammatory anti inflammatory, inflammatory anti-inflammatory analgesic properties Thus M papers Office Office® Property Property® Scopus sources food “food latter 21 44%, 44 44% , (44%) 30%. 30 30% . (30%) cosmetics pharmaceuticals beverages Sciences Biochemistry Biology rise companies Therefore demand 2 4 (44% 3 (30% (44 (30 (4 (3 (

Resumo O aquecimento global é atribuído ao aumento das emissões de gases de efeito estufa (GEE), como dióxido de carbono (CO2), metano (CH4) e óxido nitroso (N2O). As mudanças no uso da terra têm impactos significativos nas emissões de GEE, sendo responsáveis por aproximadamente 44% das emissões do país em 2019. Essa é uma revisão que aborda as principais rotas de formação dos GEE no solo com foco na influência das mudanças do uso da terra nas emissões de GEE. Constata-se que as emissões de CO2 pelo solo estão relacionadas à respiração de raízes, microrganismos e decomposição da matéria orgânica (MO) do solo, assim mudanças no uso da terra podem alterar as características do solo, favorecendo a intensificação das emissões de CO2. As emissões de CH4 pelo solo ocorrem em condições de anaerobiose por microrganismos metanogênicos, no entanto as mudanças no uso da terra, como a conversão de florestas em pastagens, podem aumentar as emissões de CH4 devido a uma maior concentração de microrganismos metanogênicos no solo. Já o N2O é produzido no solo durante o processo de nitrificação e desnitrificação por microrganismos, e a fertilização nitrogenada em áreas agrícolas pode aumentar as emissões de N2O, especialmente quando associada à umidade e disponibilidade de carbono orgânico no solo. Destaca-se a importância de compreender as dinâmicas de formação e emissão de GEE decorrentes das mudanças de uso da terra, pois estratégias eficientes de manejo podem reduzir essas emissões e contribuir para o cumprimento das metas do Brasil em relação à redução de GEE estabelecidas em acordos internacionais. , (GEE) CO2, CO (CO2) CH (CH4 N2O. NO . N (N2O) 44 2019 Constatase Constata se raízes MO (MO pastagens Destacase Destaca internacionais (GEE (CO2 (CH (N2O 4 201 (CO 20 2

Abstract Global warming is attributed to the increase in greenhouse gas (GHG) emissions, such as carbon dioxide (CO2), methane (CH4), and nitrous oxide (N2O). Land use changes significantly impact on GHG emissions, accounting for approximately 44% of the country’s emissions in 2019. This review addresses the main pathways of GHG formation in the soil, focusing on the influence of land use changes on GHG emissions. It is found that soil CO2 emissions are related to root respiration, microorganisms, and organic matter (OM) decomposition in the soil. Changes in land use can alter soil characteristics, favoring increased CO2 emissions. Soil CH4 emissions occur under anaerobic conditions by methanogenic microorganisms; however, land use changes, such as forest conversion to pasture, can increase CH4 emissions due to a higher concentration of methanogenic microorganisms in the soil. On the other hand, N2O is produced in the soil during nitrification and denitrification processes by microorganisms, and nitrogen fertilization in agricultural areas can increase N2O emissions, especially when associated with soil moisture and the availability of organic carbon. It is important to understand the dynamics of GHG formation and emissions resulting from land use changes because efficient management strategies can reduce these emissions and contribute to Brazil’s goals for GHG reduction as established in international agreements. (GHG CO2, CO , (CO2) CH4, CH (CH4) N2O. NO . N O (N2O) 44 countrys country s 2019 respiration OM (OM characteristics however pasture hand Brazils Brazil agreements (CO2 (CH4 (N2O 4 201 (CO (CH 20 2

ABSTRACT. The selection of superior sweet potato genotypes using Bayesian inference is an important strategy for genetic improvement. Sweet potatoes are of social and economic importance, being the material for ethanol production. The estimation of variance components and genetic parameters using Bayesian inference is more accurate than that using the frequently used statistical methodologies. This is because the former allows for using a priori knowledge from previous research. Therefore, the present study estimated genetic parameters and selection gains, predicted genetic values, and selected sweet potato genotypes using a Bayesian approach with a priori information. Root shape, soil insect resistance, and root and shoot productivity of 24 sweet potato genotypes were measured. Heritability, genotypic variation coefficient, residual variation coefficient, relative variation index, and selection gains direct, indirect and simultaneous were estimated, and the data were analyzed using Bayesian inference. Data from 11 experiments were used to obtain a priori information. Bayesian inference was a useful tool for decision-making, and significant genetic gains could be achieved with the selection of the evaluated genotypes. Root shape, soil insect resistance, commercial root productivity, and total root productivity showed higher heritability values. Clones UFVJM06, UFVJM40, UFVJM54, UFVJM09, and CAMBRAIA can be used as parents in future breeding programs.

Resumo Este estudo teve como objetivo verificar se a inclusão de ácidos graxos poliinsaturados ômega-3 (PUFAs-ô3) na dieta de machos de Astyanax lacustris melhora a qualidade seminal. Quatrocentos peixes foram dispostos em 20 caixas de 180 L no sistema de recirculação. Estes foram alimentados com dietas isoproteicas (32% PB) até aparente saciedade, com quatro níveis de óleo de peixe marinho rico em inclusão de PUFAs-ô3 (In% = 0, 3, 6 e 9), durante 105 dias. Após, os machos foram induzidos hormonalmente à espermiação e o sêmen foi coletado após 226 UTAs. Os parâmetros avaliados foram osmolalidade volume e cor seminal concentração espermática morfologia espermática integridade de membrana e motilidade espermática (motilidade total e progressiva velocidade curvilínea linha reta e trajeto médio coeficientes de linearidade e retilinearidade, oscilação da trajetória, amplitude de deslocamento lateral da cabeça e frequência de batida cruzada). O volume seminal foi maior nos grupos In-0 e In-3. A inclusão de PUFAs-ô3 influenciou positivamente os parâmetros cinéticos, pois o tratamento com 6% e 9% de inclusão de óleo de peixe resultou em valores mais elevados para a maioria desses parâmetros e não diferiram estatisticamente entre si. Assim, conclui-se que a adição de PUFAs-ô3 na ração dos criadores melhorou significativamente a qualidade seminal dos machos de A. lacustris. ômega3 ômega 3 ômega- PUFAsô3 PUFAsô PUFAs ô3 ô (PUFAs-ô3 2 18 recirculação 32% 32 (32 PB saciedade PUFAs-ô In% In (In 0 9, 9 , 9) 10 dias Após 22 UTAs retilinearidade trajetória cruzada. cruzada . cruzada) In0 In- In3. In3 3. In-3 cinéticos si Assim concluise conclui (PUFAs-ô 1 (3 (

Abstract This study aimed to verify whether the inclusion of omega-3 polyunsaturated fatty acids (PUFAs-ô3) in the diet of Astyanax lacustris males improves seminal quality. Four hundred fish were arranged in 20 boxes of 180 L in the recirculation system. These were fed with isoprotein diets (32% CP), until apparent satiation, with four levels of marine fish oil rich in PUFAs-ô3 inclusion (In% = 0, 3, 6, and 9), for 105 days. After, males were hormonally induced to spermiation, and semen was collected after 226 ATUs. Parameters evaluated were osmolality, seminal volume and color, spermatic concentration, sperm morphology, membrane integrity and, sperm motility (total and progressive motility, velocity curvilinear, straight line and average path, linearity and rectilinearity coefficients, trajectory oscillation, head lateral displacement amplitude, and cross-beat frequency). Seminal volume was greater in the In-0 and In-3 groups. Inclusion of PUFAs-ô3 positively influenced the kinetic parameters, as treatment with 6% and 9% of inclusion fish oil resulted in higher values for most of these parameters and did not differ statistically from each other. Thus, it is concluded that the addition of PUFAs-ô3 to the feed of breeders significantly improved the seminal quality of A. lacustris males. omega3 omega 3 omega- PUFAsô3 PUFAsô PUFAs ô3 ô (PUFAs-ô3 2 18 system 32% 32 (32 CP, CP , CP) satiation PUFAs-ô In% In (In 0 6 9, 9 9) 10 days After spermiation 22 ATUs osmolality color concentration morphology total curvilinear path coefficients oscillation amplitude crossbeat cross beat frequency. frequency . frequency) In0 In- In3 groups other Thus A (PUFAs-ô 1 (3 (

Abstract Objective To assess the association between risk factors for developing denture stomatitis (DS) and oral health-related quality of life (OHRQoL) in complete denture wearers. Methodology Participants of both sexes, wearing complete dentures, were classified using the modified Newton classification for the absence or the severity of DS and allocated to groups Normal or zero, IA, IB, II, and III. Lifestyle, oral and denture history, and medication use were assessed using specific questionnaires; clinical parameters such as anatomical characteristics of support were evaluated with the Kapur classification; salivary flow (SF) was calculated by the volume of unstimulated saliva per minute; and microbial load was determined by counting colony forming units (CFU) of target microorganisms present in the biofilm collected from dentures and palate. OHIP-EDENT assessed the OHRQoL. Kendall's tau_b and Spearman tests were applied with a significance level of 5%. Results 184 patients (143 female and 41 male) aged 65.5 ± 6.8 years were evaluated. Positive correlations were found for sex (women; p=0.013, r=0.16), individuals who started to consume alcoholic beverages as a young adult (18–27 years) (p=0.008, r=0.22), CFU of Candida spp. (p<0.001, r=0.27 denture; p<0.001, r=0.31 palate); Candida albicans (p=0.004, r=0.22 denture; p=0.003, r=0.25 palate), and Candida glabrata (p=0.004, r=0.22 denture; p=0.001, r=0.27 palate). Moreover, negative correlations with DS were found for CFU of Staphylococcus spp. (p=0.004, r=-0.20 palate) and enterobacteria (p=0.002, r=-0.24 palate), as well as a negative correlation between SF (p=0.009, r=-0.193) and DS. The CFU of Staphylococcus spp. and enterobacteria on the palate significantly correlated with OHRQoL. Conclusion Being female, consuming alcoholic beverages as a young adult, CFU of Candida spp., Candida albicans, Candida glabrata, and salivary flow may be the most significant risk factors for DS. The microbial load of Staphylococcus spp. and enterobacteria seems to influence the quality of life for complete denture wearers. (DS healthrelated health related OHRQoL (OHRQoL wearers sexes zero IA IB II III Lifestyle history questionnaires (SF minute (CFU OHIPEDENT OHIP EDENT Kendalls Kendall s taub tau b 5 5% 18 143 (14 4 male 655 65 65. 68 6 8 6. women (women p0013 p 0 013 p=0.013 r=0.16, r016 r r=0.16 , 16 r=0.16) 18–27 1827 27 (18–2 p=0.008, p0008 008 (p=0.008 r=0.22, r022 22 r=0.22) spp p0001 001 (p<0.001 r027 r=0.2 p<0.001 r031 31 r=0.3 p=0.004, p0004 004 (p=0.004 p0003 003 p=0.003 r025 25 palate, p=0.001 . Moreover r=0.20 r020 r= 0.20 20 r=-0.2 p=0.002, p0002 002 (p=0.002 r=0.24 r024 0.24 24 p=0.009, p0009 009 (p=0.009 r=0.193 r0193 0.193 193 r=-0.193 1 14 (1 p001 01 p=0.01 r01 r=0.1 18–2 182 2 (18– p=0.008 p000 00 (p=0.00 r02 (p<0.00 r=0. p<0.00 r03 3 p=0.004 p=0.00 020 0.2 r=-0. p=0.002 024 p=0.009 r=0.19 r019 0193 0.19 19 r=-0.19 ( p00 p=0.0 r0 18– (18 (p=0.0 (p<0.0 r=0 p<0.0 02 0. r=-0 019 0.1 r=-0.1 p0 p=0. (p=0. (p<0. p<0. r=- p=0 (p=0 (p<0 p<0 p= (p= (p< p< (p

BACKGROUND A positive Trypanosoma cruzi polymerase chain reaction (PCR) is associated with a worse prognosis in patients with chronic Chagas disease (CD). OBJECTIVES To study the association of clinical, electrocardiographic, and echocardiographic characteristics and biomarker blood levels with positive T. cruzi PCR in chronic CD. METHODS This is a single-centre observational cross-sectional study. Positive T. cruzi PCR association with clinical, electrocardiographic, and echocardiographic characteristics, and biomarker blood levels were studied by logistic regression analysis. p values < 0.05 were considered significant. FINDINGS Among 333 patients with chronic CD (56.4% men; 62 ± 10 years), T. cruzi PCR was positive in 41.1%. Stepwise multivariate logistic regression showed an independent association between positive T. cruzi PCR and diabetes mellitus {odds ratio (OR) 0.53 [95% confidence interval (CI) 0.30-0.93]; p = 0.03}, right bundle branch block [OR 1.78 (95% CI 1.09-2.89); p = 0.02], and history of trypanocidal treatment [OR 0.13 (95% CI 0.04-0.38); p = 0.0002]. Among patients with a history of trypanocidal treatment (n = 39), only four (10%) patients had a positive T. cruzi PCR. MAIN CONCLUSIONS Among several studied parameters, only diabetes mellitus, right bundle branch block, and history of trypanocidal treatment showed an independent association with positive T. cruzi PCR. History of trypanocidal treatment was a strong protective factor against a positive T. cruzi PCR. (PCR . (CD) clinical electrocardiographic T singlecentre single centre crosssectional cross sectional analysis 005 0 05 0.0 significant 33 56.4% 564 56 4 (56.4 men 6 1 years, years , years) 411 41 41.1% odds OR (OR 053 53 0.5 95% 95 [95 (CI 0.300.93 030093 0.30 0.93 30 93 0.30-0.93] 0.03, 003 0.03 03 0.03} 178 78 1.7 (95 1.092.89 109289 1.09 2.89 09 2 89 1.09-2.89) 0.02, 002 0.02 02 0.02] 013 13 0.1 0.040.38 004038 0.04 0.38 04 38 0.04-0.38) 0.0002. 00002 0.0002 0002 0.0002] n 39, 39 39) 10% (10% parameters (CD 00 0. 3 56.4 5 (56. 41.1 9 [9 300 0.300.9 03009 030 0.3 093 0.9 0.30-0.93 17 7 1. (9 092 1.092.8 10928 109 1.0 289 2.8 8 1.09-2.89 01 040 0.040.3 00403 004 038 0.04-0.38 0000 0.000 000 (10 56. (56 41. [ 0.300. 0300 0.30-0.9 ( 1.092. 1092 28 2. 1.09-2.8 0.040. 0040 0.04-0.3 0.00 (1 (5 0.300 0.30-0. 1.092 1.09-2. 0.040 0.04-0. 0.30-0 1.09-2 0.04-0 0.30- 1.09- 0.04-

Resumo Contexto A obtenção de uma imagem adequada da agulha pelo ultrassom diminui complicações decorrentes de punções, trazendo segurança para os pacientes e diminuindo custos com hospitalização. Objetivos Verificar a percepção do olho humano em relação aos pixels, identificar qual o melhor ângulo da punção e qual agulha deve ser utilizada e avaliar se há diferença com o uso de software de visualização de agulha. Métodos Vinte imagens foram analisadas por 103 alunos, que as classificaram como sendo suficientes ou insuficientes, e comparadas com a qualidade observada pelo photoshop. Avaliou-se se havia diferença entre punções com menos de 45º e mais de 45º, entre cateter EV e agulha introdutora e entre imagens obtidas com e sem software de visualização. Resultados Houve um percentual mais elevado de imagens suficientes entre aquelas que tinham mais de 60 pixels e quando o ângulo era menor que 45º, com associação significativa entre a classificação das avaliações pelos alunos e cada um desses grupos (p < 0,001). O percentual de imagens suficientes foi maior nas imagens realizadas com cateter EV e naquelas que utilizaram o software de visualização da agulha, ocorrendo associação significativa entre os resultados da classificação pelos alunos e cada um desses grupos (p < 0,001). Conclusões O olho humano classifica a imagem como sendo suficiente de acordo com a maior quantidade de pixels. Imagens puncionadas com ângulos menores que 45º em relação à superfície, realizadas com cateter EV e utilizando software específico de visualização também são mais bem detectadas pelo olho humano. hospitalização 10 insuficientes photoshop Avaliouse Avaliou º 6 p 0,001. 0001 0,001 . 0 001 0,001) superfície 1 000 0,00 00 0,0 0,

Abstract Background Obtaining an adequate image of the needle by ultrasound reduces complications resulting from punctures, increasing patient safety and reducing hospitalization costs. Objectives To verify human perception in relation to number of pixels, while also identifying the best puncture angle and which needle should be used, and to evaluate whether there is a difference if needle visualization software is used. Methods 20 images were analyzed by 103 students who classified them as being sufficient or insufficient and were compared with the quality observed using photoshop. We evaluated whether there were differences between puncture angles of less than 45º and more than 45º, between IV catheter and introducer needles, and between images obtained with and without visualization software. Results There was a higher percentage of sufficient ratings for images those that had more than 60 pixels and when the puncture angle was less than 45º, with significant associations between students’ evaluations and each of these groups (p < 0.001). The percentages of images classified as sufficient were higher for images in which a IV catheter was used and also higher for those using the needle visualization software, with significant associations between the results for students’ classifications and each of these groups (p < 0.001). Conclusions The human eye classifies an image as sufficient according to higher numbers of pixels. Images of punctures at angles smaller than 45º in relation to the surface, of punctures performed with a IV catheter, and when using specific visualization software are also better detected by the human eye. costs 2 10 photoshop º needles 6 p 0.001. 0001 0.001 . 0 001 0.001) surface 1 000 0.00 00 0.0 0.

Resumo O objetivo deste artigo é apontar hipóteses de contradições que estariam incubadas historicamente nos sistemas de atividades da Vale, e que podem ter levado ao maior desastre ambiental do Brasil: o rompimento da barragem B I em Brumadinho, bem como à interdição de muitas outras barragens da empresa no estado de Minas Gerais, Brasil. Trata-se de uma análise de caso a partir de dados secundários disponíveis em entrevistas, documentos e textos publicados em diferentes mídias entre 2011 e 2021. Procuramos demonstrar, a partir da Teoria Histórico-Cultural da Atividade, as contradições verificadas em e entre sistemas de atividades da Vale, pois a empresa distribuiu dividendos vultosos aos seus acionistas, remunerou como nunca seus diretores, reduziu os custos em relação às receitas e diminuiu brutalmente a dívida interna, mas manteve investimentos insuficientes na gestão das barragens, culminando no rompimento da B I em 2019 e em 29 barragens interditadas em março de 2021. A financeirização tornou-se central para as operações da empresa. Este estudo aponta para um caminho metodológico do diálogo interdisciplinar que ajuda a esclarecer como as decisões gerenciais estratégicas, especialmente aquelas da gestão financeira, poderiam influenciar a gestão de produção, de manutenção e de segurança das barragens de rejeitos. Vale Brasil Brumadinho Gerais Tratase Trata se entrevistas 201 2021 demonstrar HistóricoCultural Histórico Cultural Atividade acionistas diretores interna 2 tornouse tornou estratégicas financeira produção rejeitos 20 202

Abstract The objective of this article is to point out hypotheses of contradictions historically incubated in Vale’s activity systems and that may have led to Brazil’s biggest environmental disaster, the B I dam break in Brumadinho, and the interdiction of many other dams owned by Vale in the state of Minas Gerais, Brazil. This is a case analysis from secondary data available in interviews, documents, and texts published in different media between 2011 and 2021. We try to demonstrate, from the Historical-Cultural Theory of Activity, the contradictions verified in and between Vale’s activity systems, since the company distributed large dividends to its shareholders, remunerated its directors as never before, reduced costs in relation to incomes, and brutally reduced internal debt, but keeping insufficient investments in dam management, culminating with the break of B I in 2019 and with 29 dams interdicted in March 2021. Financialization has become central to the company’s operations. This study points to a methodological path of the interdisciplinary dialogue to help clarify how strategic managerial decisions, especially those of financial management, could influence the production, maintenance, and safety management of tailings dams. Vales s Brazils Brazil disaster Brumadinho Gerais interviews documents 201 2021 demonstrate HistoricalCultural Historical Cultural Activity shareholders before incomes debt 2 companys operations decisions production maintenance 20 202