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Catálogo Taxonômico da Fauna do Brasil: Setting the baseline knowledge on the animal diversity in Brazil Brasil
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Boeger, Walter A.
; Valim, Michel P.
; Zaher, Hussam
; Rafael, José A.
; Forzza, Rafaela C.
; Percequillo, Alexandre R.
; Serejo, Cristiana S.
; Garraffoni, André R.S.
; Santos, Adalberto J.
; Slipinski, Adam
; Linzmeier, Adelita M.
; Calor, Adolfo R.
; Garda, Adrian A.
; Kury, Adriano B.
; Fernandes, Agatha C.S.
; Agudo-Padrón, Aisur I.
; Akama, Alberto
; Silva Neto, Alberto M. da
; Burbano, Alejandro L.
; Menezes, Aleksandra
; Pereira-Colavite, Alessandre
; Anichtchenko, Alexander
; Lees, Alexander C.
; Bezerra, Alexandra M.R.
; Domahovski, Alexandre C.
; Pimenta, Alexandre D.
; Aleixo, Alexandre L.P.
; Marceniuk, Alexandre P.
; Paula, Alexandre S. de
; Somavilla, Alexandre
; Specht, Alexandre
; Camargo, Alexssandro
; Newton, Alfred F.
; Silva, Aline A.S. da
; Santos, Aline B. dos
; Tassi, Aline D.
; Aragão, Allan C.
; Santos, Allan P.M.
; Migotto, Alvaro E.
; Mendes, Amanda C.
; Cunha, Amanda
; Chagas Júnior, Amazonas
; Sousa, Ana A.T. de
; Pavan, Ana C.
; Almeida, Ana C.S.
; Peronti, Ana L.B.G.
; Henriques-Oliveira, Ana L.
; Prudente, Ana L.
; Tourinho, Ana L.
; Pes, Ana M.O.
; Carmignotto, Ana P.
; Wengrat, Ana P.G. da Silva
; Dornellas, Ana P.S.
; Molin, Anamaria Dal
; Puker, Anderson
; Morandini, André C.
; Ferreira, André da S.
; Martins, André L.
; Esteves, André M.
; Fernandes, André S.
; Roza, André S.
; Köhler, Andreas
; Paladini, Andressa
; Andrade, Andrey J. de
; Pinto, Ângelo P.
; Salles, Anna C. de A.
; Gondim, Anne I.
; Amaral, Antonia C.Z.
; Rondón, Antonio A.A.
; Brescovit, Antonio
; Lofego, Antônio C.
; Marques, Antonio C.
; Macedo, Antonio
; Andriolo, Artur
; Henriques, Augusto L.
; Ferreira Júnior, Augusto L.
; Lima, Aurino F. de
; Barros, Ávyla R. de A.
; Brito, Ayrton do R.
; Romera, Bárbara L.V.
; Vasconcelos, Beatriz M.C. de
; Frable, Benjamin W.
; Santos, Bernardo F.
; Ferraz, Bernardo R.
; Rosa, Brunno B.
; Sampaio, Brunno H.L.
; Bellini, Bruno C.
; Clarkson, Bruno
; Oliveira, Bruno G. de
; Corrêa, Caio C.D.
; Martins, Caleb C.
; Castro-Guedes, Camila F. de
; Souto, Camilla
; Bicho, Carla de L.
; Cunha, Carlo M.
; Barboza, Carlos A. de M.
; Lucena, Carlos A.S. de
; Barreto, Carlos
; Santana, Carlos D.C.M. de
; Agne, Carlos E.Q.
; Mielke, Carlos G.C.
; Caetano, Carlos H.S.
; Flechtmann, Carlos H.W.
; Lamas, Carlos J.E.
; Rocha, Carlos
; Mascarenhas, Carolina S.
; Margaría, Cecilia B.
; Waichert, Cecilia
; Digiani, Celina
; Haddad, Célio F.B.
; Azevedo, Celso O.
; Benetti, Cesar J.
; Santos, Charles M.D. dos
; Bartlett, Charles R.
; Bonvicino, Cibele
; Ribeiro-Costa, Cibele S.
; Santos, Cinthya S.G.
; Justino, Cíntia E.L.
; Canedo, Clarissa
; Bonecker, Claudia C.
; Santos, Cláudia P.
; Carvalho, Claudio J.B. de
; Gonçalves, Clayton C.
; Galvão, Cleber
; Costa, Cleide
; Oliveira, Cléo D.C. de
; Schwertner, Cristiano F.
; Andrade, Cristiano L.
; Pereira, Cristiano M.
; Sampaio, Cristiano
; Dias, Cristina de O.
; Lucena, Daercio A. de A.
; Manfio, Daiara
; Amorim, Dalton de S.
; Queiroz, Dalva L. de
; Queiroz, Dalva L. de
; Colpani, Daniara
; Abbate, Daniel
; Aquino, Daniel A.
; Burckhardt, Daniel
; Cavallari, Daniel C.
; Prado, Daniel de C. Schelesky
; Praciano, Daniel L.
; Basílio, Daniel S.
; Bená, Daniela de C.
; Toledo, Daniela G.P. de
; Takiya, Daniela M.
; Fernandes, Daniell R.R.
; Ament, Danilo C.
; Cordeiro, Danilo P.
; Silva, Darliane E.
; Pollock, Darren A.
; Muniz, David B.
; Gibson, David I.
; Nogueira, David S.
; Marques, Dayse W.A.
; Lucatelli, Débora
; Garcia, Deivys M.A.
; Baêta, Délio
; Ferreira, Denise N.M.
; Rueda-Ramírez, Diana
; Fachin, Diego A.
; Souza, Diego de S.
; Rodrigues, Diego F.
; Pádua, Diego G. de
; Barbosa, Diego N.
; Dolibaina, Diego R.
; Amaral, Diogo C.
; Chandler, Donald S.
; Maccagnan, Douglas H.B.
; Caron, Edilson
; Carvalho, Edrielly
; Adriano, Edson A.
; Abreu Júnior, Edson F. de
; Pereira, Edson H.L.
; Viegas, Eduarda F.G.
; Carneiro, Eduardo
; Colley, Eduardo
; Eizirik, Eduardo
; Santos, Eduardo F. dos
; Shimbori, Eduardo M.
; Suárez-Morales, Eduardo
; Arruda, Eliane P. de
; Chiquito, Elisandra A.
; Lima, Élison F.B.
; Castro, Elizeu B. de
; Orlandin, Elton
; Nascimento, Elynton A. do
; Razzolini, Emanuel
; Gama, Emanuel R.R.
; Araujo, Enilma M. de
; Nishiyama, Eric Y.
; Spiessberger, Erich L.
; Santos, Érika C.L. dos
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; Galati, Eunice A.B.
; Oliveira Junior, Evaldo C. de
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; Hernandes, Fabio A.
; Lansac-Tôha, Fábio A.
; Pitombo, Fabio B.
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; Santos, Fábio L. dos
; Mauro, Fabio
; Nascimento, Fabio O. do
; Olmos, Fabio
; Amaral, Fabio R.
; Schunck, Fabio
; Godoi, Fábio S. P. de
; Machado, Fabrizio M.
; Barbo, Fausto E.
; Agrain, Federico A.
; Ribeiro, Felipe B.
; Moreira, Felipe F.F.
; Barbosa, Felipe F.
; Silva, Fenanda S.
; Cavalcanti, Fernanda F.
; Straube, Fernando C.
; Carbayo, Fernando
; Carvalho Filho, Fernando
; Zanella, Fernando C.V.
; Jacinavicius, Fernando de C.
; Farache, Fernando H.A.
; Leivas, Fernando
; Dias, Fernando M.S.
; Mantellato, Fernando
; Vaz-de-Mello, Fernando Z.
; Gudin, Filipe M.
; Albuquerque, Flávio
; Molina, Flavio B.
; Passos, Flávio D.
; Shockley, Floyd W.
; Pinheiro, Francielly F.
; Mello, Francisco de A.G. de
; Nascimento, Francisco E. de L.
; Franco, Francisco L.
; Oliveira, Francisco L. de
; Melo, Francisco T. de V.
; Quijano, Freddy R.B.
; Salles, Frederico F.
; Biffi, Gabriel
; Queiroz, Gabriel C.
; Bizarro, Gabriel L.
; Hrycyna, Gabriela
; Leviski, Gabriela
; Powell, Gareth S.
; Santos, Geane B. dos
; Morse, Geoffrey E.
; Brown, George
; Mattox, George M.T.
; Zimbrão, Geraldo
; Carvalho, Gervásio S.
; Miranda, Gil F.G.
; Moraes, Gilberto J. de
; Lourido, Gilcélia M.
; Neves, Gilmar P.
; Moreira, Gilson R.P.
; Montingelli, Giovanna G.
; Maurício, Giovanni N.
; Marconato, Gláucia
; Lopez, Guilherme E.L.
; Silva, Guilherme L. da
; Muricy, Guilherme
; Brito, Guilherme R.R.
; Garbino, Guilherme S.T.
; Flores, Gustavo E.
; Graciolli, Gustavo
; Libardi, Gustavo S.
; Proctor, Heather C.
; Gil-Santana, Helcio R.
; Varella, Henrique R.
; Escalona, Hermes E.
; Schmitz, Hermes J.
; Rodrigues, Higor D.D.
; Galvão Filho, Hilton de C.
; Quintino, Hingrid Y.S.
; Pinto, Hudson A.
; Rainho, Hugo L.
; Miyahira, Igor C.
; Gonçalves, Igor de S.
; Martins, Inês X.
; Cardoso, Irene A.
; Oliveira, Ismael B. de
; Franz, Ismael
; Fernandes, Itanna O.
; Golfetti, Ivan F.
; S. Campos-Filho, Ivanklin
; Oliveira, Ivo de S.
; Delabie, Jacques H.C.
; Oliveira, Jader de
; Prando, Jadila S.
; Patton, James L.
; Bitencourt, Jamille de A.
; Silva, Janaina M.
; Santos, Jandir C.
; Arruda, Janine O.
; Valderrama, Jefferson S.
; Dalapicolla, Jeronymo
; Oliveira, Jéssica P.
; Hájek, Jiri
; Morselli, João P.
; Narita, João P.
; Martin, João P.I.
; Grazia, Jocélia
; McHugh, Joe
; Cherem, Jorge J.
; Farias Júnior, José A.S.
; Fernandes, Jose A.M.
; Pacheco, José F.
; Birindelli, José L.O.
; Rezende, José M.
; Avendaño, Jose M.
; Duarte, José M. Barbanti
; Ribeiro, José R. Inácio
; Mermudes, José R.M.
; Pujol-Luz, José R.
; Santos, Josenilson R. dos
; Câmara, Josenir T.
; Teixeira, Joyce A.
; Prado, Joyce R. do
; Botero, Juan P.
; Almeida, Julia C.
; Kohler, Julia
; Gonçalves, Julia P.
; Beneti, Julia S.
; Donahue, Julian P.
; Alvim, Juliana
; Almeida, Juliana C.
; Segadilha, Juliana L.
; Wingert, Juliana M.
; Barbosa, Julianna F.
; Ferrer, Juliano
; Santos, Juliano F. dos
; Kuabara, Kamila M.D.
; Nascimento, Karine B.
; Schoeninger, Karine
; Campião, Karla M.
; Soares, Karla
; Zilch, Kássia
; Barão, Kim R.
; Teixeira, Larissa
; Sousa, Laura D. do N.M. de
; Dumas, Leandro L.
; Vieira, Leandro M.
; Azevedo, Leonardo H.G.
; Carvalho, Leonardo S.
; Souza, Leonardo S. de
; Rocha, Leonardo S.G.
; Bernardi, Leopoldo F.O.
; Vieira, Letícia M.
; Johann, Liana
; Salvatierra, Lidianne
; Oliveira, Livia de M.
; Loureiro, Lourdes M.A. El-moor
; Barreto, Luana B.
; Barros, Luana M.
; Lecci, Lucas
; Camargos, Lucas M. de
; Lima, Lucas R.C.
; Almeida, Lucia M.
; Martins, Luciana R.
; Marinoni, Luciane
; Moura, Luciano de A.
; Lima, Luciano
; Naka, Luciano N.
; Miranda, Lucília S.
; Salik, Lucy M.
; Bezerra, Luis E.A.
; Silveira, Luis F.
; Campos, Luiz A.
; Castro, Luiz A.S. de
; Pinho, Luiz C.
; Silveira, Luiz F.L.
; Iniesta, Luiz F.M.
; Tencatt, Luiz F.C.
; Simone, Luiz R.L.
; Malabarba, Luiz R.
; Cruz, Luiza S. da
; Sekerka, Lukas
; Barros, Lurdiana D.
; Santos, Luziany Q.
; Skoracki, Maciej
; Correia, Maira A.
; Uchoa, Manoel A.
; Andrade, Manuella F.G.
; Hermes, Marcel G.
; Miranda, Marcel S.
; Araújo, Marcel S. de
; Monné, Marcela L.
; Labruna, Marcelo B.
; Santis, Marcelo D. de
; Duarte, Marcelo
; Knoff, Marcelo
; Nogueira, Marcelo
; Britto, Marcelo R. de
; Melo, Marcelo R.S. de
; Carvalho, Marcelo R. de
; Tavares, Marcelo T.
; Kitahara, Marcelo V.
; Justo, Marcia C.N.
; Botelho, Marcia J.C.
; Couri, Márcia S.
; Borges-Martins, Márcio
; Felix, Márcio
; Oliveira, Marcio L. de
; Bologna, Marco A.
; Gottschalk, Marco S.
; Tavares, Marcos D.S.
; Lhano, Marcos G.
; Bevilaqua, Marcus
; Santos, Marcus T.T.
; Domingues, Marcus V.
; Sallum, Maria A.M.
; Digiani, María C.
; Santarém, Maria C.A.
; Nascimento, Maria C. do
; Becerril, María de los A.M.
; Santos, Maria E.A. dos
; Passos, Maria I. da S. dos
; Felippe-Bauer, Maria L.
; Cherman, Mariana A.
; Terossi, Mariana
; Bartz, Marie L.C.
; Barbosa, Marina F. de C.
; Loeb, Marina V.
; Cohn-Haft, Mario
; Cupello, Mario
; Martins, Marlúcia B.
; Christofersen, Martin L.
; Bento, Matheus
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; Segura, Melissa O.
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; Duarte, Mércia E.
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; Fernandez, Monica A.
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; Benaim, Natalia P.
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; Pedro, Natan C.
; Pecly, Nathalia H.
; Ferreira Júnior, Nelson
; Silva Júnior, Nelson J. da
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; Hamada, Neusa
; Degallier, Nicolas
; Chao, Ning L.
; Ferla, Noeli J.
; Mielke, Olaf H.H.
; Evangelista, Olivia
; Shibatta, Oscar A.
; Oliveira, Otto M.P.
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ABSTRACT The limited temporal completeness and taxonomic accuracy of species lists, made available in a traditional manner in scientific publications, has always represented a problem. These lists are invariably limited to a few taxonomic groups and do not represent up-to-date knowledge of all species and classifications. In this context, the Brazilian megadiverse fauna is no exception, and the Catálogo Taxonômico da Fauna do Brasil (CTFB) (http://fauna.jbrj.gov.br/), made public in 2015, represents a database on biodiversity anchored on a list of valid and expertly recognized scientific names of animals in Brazil. The CTFB is updated in near real time by a team of more than 800 specialists. By January 1, 2024, the CTFB compiled 133,691 nominal species, with 125,138 that were considered valid. Most of the valid species were arthropods (82.3%, with more than 102,000 species) and chordates (7.69%, with over 11,000 species). These taxa were followed by a cluster composed of Mollusca (3,567 species), Platyhelminthes (2,292 species), Annelida (1,833 species), and Nematoda (1,447 species). All remaining groups had less than 1,000 species reported in Brazil, with Cnidaria (831 species), Porifera (628 species), Rotifera (606 species), and Bryozoa (520 species) representing those with more than 500 species. Analysis of the CTFB database can facilitate and direct efforts towards the discovery of new species in Brazil, but it is also fundamental in providing the best available list of valid nominal species to users, including those in science, health, conservation efforts, and any initiative involving animals. The importance of the CTFB is evidenced by the elevated number of citations in the scientific literature in diverse areas of biology, law, anthropology, education, forensic science, and veterinary science, among others. publications problem uptodate up date classifications context exception (CTFB http//fauna.jbrj.gov.br/, httpfaunajbrjgovbr http //fauna.jbrj.gov.br/ , jbrj gov br (http://fauna.jbrj.gov.br/) 2015 Brazil 80 specialists 1 2024 133691 133 691 133,69 125138 125 138 125,13 82.3%, 823 82 3 (82.3% 102000 102 000 102,00 7.69%, 769 7 69 (7.69% 11000 11 11,00 . 3,567 3567 567 (3,56 2,292 2292 2 292 (2,29 1,833 1833 833 (1,83 1,447 1447 447 (1,44 1000 1,00 831 (83 628 (62 606 (60 520 (52 50 users science health biology law anthropology education others http//fauna.jbrj.gov.br/ faunajbrjgovbr //fauna.jbrj.gov.br (http://fauna.jbrj.gov.br/ 201 8 202 13369 13 133,6 12513 12 125,1 82.3% (82.3 10200 10 00 102,0 7.69% 76 6 (7.69 1100 11,0 3,56 356 56 (3,5 2,29 229 29 (2,2 1,83 183 83 (1,8 1,44 144 44 (1,4 100 1,0 (8 62 (6 60 52 (5 5 http//fauna.jbrj.gov.br (http://fauna.jbrj.gov.br 20 1336 133, 1251 125, 82.3 (82. 1020 0 102, 7.69 (7.6 110 11, 3,5 35 (3, 2,2 22 (2, 1,8 18 (1, 1,4 14 4 ( 82. (82 7.6 (7. 3, (3 2, (2 (1 7. (7
2.
Enhanced Larvicidal Activity of New 1,2,4-Oxadiazoles against Aedes aegypti Mosquitos: QSAR and Docking Studies 1,2,4Oxadiazoles 124Oxadiazoles Oxadiazoles 1,2,4 1 2 4 Mosquitos 4Oxadiazoles 124 1,2, 12 1,2 1,
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Silva, Aluízio G. da
; Navarro, Daniela Maria A. F.
; Santos, Geanne K. N.
; Aguiar, Júlio César R. O. F. de
; França, Karla A. de
; Tébéka, Iris Raquel M.
; Anjos, Janaína V. dos
; Silva, João Bosco P. da
; Kanis, Luiz A.
; Srivastava, Rajendra M.
; Neves Filho, Ricardo Antônio W.
; Ramos, Mozart N.
.
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The worldwide emergence of viral diseases such as Zika, Dengue, Chikungunya, West Nile and Yellow Fever urge the search for solutions to eliminate their common vector, the Aedes aegypti mosquito. This paper describes the quantitative structure-activity relationship (QSAR) and docking studies of a series of nine 3-(3-aryl-1,2,4-oxadiazol-5-yl)propionic acids (AOPA), 1-9, previously published by our group. Additionally, three new 1,2,4-oxadiazoles, 10-12, have also been synthesized, characterized and studied. The QSAR and docking studies of all compounds, 1-12, clearly indicate that larger hydrophobic substituents such as biphenyl groups attached on position 3 in 1,2,4-oxadiazoles improve the larvicidal activity. It is worthwhile to mention that nanocapsulation of compounds 10-12 were necessary to help their dissolution in water and these three new 1,2,4-oxadiazoles also exhibited approximately equal or higher larvicidal activities compared to the former prototypes at stage L4. Zika Dengue Chikungunya vector mosquito structureactivity structure activity (QSAR 33aryl1,2,4oxadiazol5ylpropionic 33aryl124oxadiazol5ylpropionic aryloxadiazolylpropionic aryl 1,2,4 oxadiazol 5 yl propionic 1 2 4 AOPA, AOPA , (AOPA) 19, 19 9, 9 1-9 group Additionally 1,2,4oxadiazoles, 124oxadiazoles oxadiazoles oxadiazoles, 1012, 1012 10 12, 12 synthesized studied 112, 112 1-12 1,2,4oxadiazoles 10-1 L4 L 33aryl1 4oxadiazol5ylpropionic ylpropionic 124 1,2, (AOPA 1- 4oxadiazoles 101 11 1-1 10- 33aryl oxadiazolylpropionic 1,2 1,
3.
Supercritical Carbon Dioxide Effect on Lipase-Catalyzed Geranyl Acetate Synthesis
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Tavares, Matheus V. L.
; Kanda, Luís R. S.
; Giacomin Júnior, Wanderson R.
; Ramos, Luiz P.
; Vandenberghe, Luciana P. S.
; Corazza, Marcos L.
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This work provides a general insight on lipase-catalyzed synthesis of geranyl acetate through esterification of geraniol with acetic acid. Although this reaction is relatively well known, the replacement of organic solvents by supercritical fluids is fairly recent and the role of CO2 is still not completely understood. Therefore, reactions were performed with Lipozyme® RM IM and Novozym® 435 as biocatalysts, and hexane and CO2 as solvents. For similar reaction conditions, geraniol conversions obtained using hexane were much higher, rather than supercritical CO2 (scCO2, 82.9% versus 12.0% after 4 h). The results obtained indicated that CO2 might help the migration of water from the enzyme surface to reaction bulk and then to the vapor phase. Thus, by increasing the vapor phase extension, the geraniol conversion enhanced to 60.5% after 4 h. Such improvement represents one step forward to comprehend the influence of CO2, a safer and greener solvent as compared to hexane.
4.
Carga de Doenças Cardiovasculares Atribuível aos Fatores de Risco nos Países de Língua Portuguesa: Dados do Estudo “Global Burden of Disease 2019”
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Nascimento, Bruno Ramos
; Brant, Luisa Campos Caldeira
; Naback, André Dias Nassar
; Veloso, Guilherme Augusto
; Polanczyk, Carisi Anne
; Ribeiro, Antonio Luiz Pinho
; Malta, Deborah Carvalho
; Ferreira, Albano Vicente Lopes
; Oliveira, Gláucia Maria Moraes de
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Resumo Fundamento: O impacto dos fatores de risco (FR) sobre a morbimortalidade por doença cardiovascular (DCV) na maioria dos países de língua portuguesa (PLP) é pouco conhecido. Objetivo: Analisar a morbimortalidade por DCV atribuível aos FR e sua variação nos PLP de 1990 a 2019, a partir de estimativas do estudo Global Burden of Disease (GBD) 2019. Métodos: Avaliamos as mudanças nos FR ocorridas no período, as taxas de mortalidade e os anos de vida perdidos por incapacidade (DALYs), padronizados por idade, entre 1990 e 2019. Realizou-se a correlação entre a variação percentual das taxas de mortalidade e o índice sociodemográfico (SDI) de cada PLP pelo método de Spearman. O valor p<0,05 foi considerado estatisticamente significativo. Resultados: A pressão arterial sistólica (PAS) elevada foi o principal fator de risco para mortalidade e DALY por DCV para todos os PLP. A mortalidade por DCV mostrou uma tendência de redução em 2019, maior em Portugal (-66,6%, IC95% -71,0 - -61,2) e no Brasil (-49,8%, IC95% -52,5 - -47,1). Observou-se tendência à correlação inversa entre SDI e a variação percentual da mortalidade, que foi significativa para os riscos dietéticos (r=-0,70, p=0,036), colesterol LDL elevado (r=-0,77, p=0,015) e PAS elevada (r=-0,74, p=0,023). Conclusões: Além da PAS, os FR dietéticos e metabólicos justificaram uma maior variação da carga de DCV, correlacionada com o SDI nos PLP, sugerindo a necessidade de adoção de políticas de saúde adaptadas à realidade de cada país, visando a redução de seu impacto sobre a população.
Abstract Background: The impact of risk factors (RF) on morbidity and mortality from cardiovascular disease (CVD) for most Portuguese-speaking countries (PSC) is little known. Objectives: We aimed to analyze the morbidity and mortality from CVD attributable to RF and its variation, from 1990 to 2019, in PSC, based on estimates from the Global Burden of Disease (GBD) 2019 study. Methods: We evaluated changes in cardiovascular RF, mortality rates and age-standardized disability-adjusted life years (DALYs) between 1990 and 2019. The correlation between percentage changes in mortality rates and the sociodemographic index (SDI) of each PSC was evaluated by the Spearman method. A p-value <0.05 was considered statistically significant. Results: Elevated systolic blood pressure (SBP) was the main RF for mortality and DALYs for CVD for all PSC. Mortality from CVD showed a downward trend in 2019, more accentuated in Portugal (-66.6%, 95%CI -71.0 - -61.2) and in Brazil (-49.8%, 95%CI -52.5 - -47.1). There was a trend towards an inverse correlation between SDI and the percent change in mortality, which was significant for dietary risks (r=-0.70, p=0.036), high LDL cholesterol (r=-0.77, p=0.015) and high SBP (r=-0.74, p=0.023). Conclusions: In addition to SBP, dietary and metabolic RF justified a greater variation in the burden of CVD correlated with SDI in the PSC, suggesting the need to adopt health policies adapted to the reality of each country, aiming to reduce their impact on population.
5.
ASPECTOS QUÍMICOS DA BIOMINERALIZAÇÃO ÓSSEA
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Cruz, Marcos A.E.
; Ferreira, Claudio R.
; Nogueira, Lucas F. B.
; Andrilli, Luiz H.S.
; Santos, Ana Lara N. dos
; Macedo, Jeferson M. M.
; Veschi, Ekeveliny A.
; Favarin, Bruno Z.
; Sebinelli, Heitor G.
; Bolean, Mayte
; Ramos, Ana Paula
; Ciancaglini, Pietro
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The bone formation process is an example of how both time and nature acted harmonically to pave the path for life as we know. The unique association between calcium phosphate (CaP) and collagen in a single building block, gave rise to one of the most remarkable biomaterials that we know. Our aim in this revision is to provide a brief glance at the different organization levels of the bone tissue, by describing the main their main features. We start with a brief discussion regarding the thermodynamic conditions for mineral formation and how living organisms surpass them. Then we present collagen, the major organic component of bone, in the light of its hierarchical organization as well as its association to CaP crystals. The mechanisms that control both mineral formation and the association with the organic phase are further presented, in which cells and other components of the extracellular matrix, such as matrix vesicles and noncollagenous proteins, become agents of bone construction. Finally, we underline the difficulty of studying the complex process of bone mineralization and present liposomes, proteoliposomes, and Langmuir monolayers as biomimetic approaches to this end.
6.
COVID-19 in the Perioperative Period of Cardiovascular Surgery: the Brazilian Experience
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Gomes, Walter J.
; Rocco, Isadora
; Pimentel, Wallace S.
; Pinheiro, Aislan H. B.
; Souza, Paulo M. S.
; Costa, Luiz A. A.
; Teixeira, Marjory M. P.
; Ohashi, Leonardo P.
; Bublitz, Caroline
; Begot, Isis
; Moreira, Rita Simone L
; Hossne Jr, Nelson A.
; Vargas, Guilherme F.
; Branco, João Nelson R.
; Teles, Carlos A.
; Medeiros, Eduardo A. S.
; Sáfadi, Camila
; Rampinelli, Amândio
; Moratelli Neto, Leopoldo
; Rosado, Anderson Rosa
; Mesacasa, Franciele Kuhn
; Capriata, Ismael Escobar
; Segalote, Rodrigo Coelho
; Palmieri, Deborah Louize da Rocha Vianna
; Jardim, Amanda Cristina Mendes
; Vianna, Diego Sarty
; Coutinho, Joaquim Henrique de Souza Aguiar
; Jazbik, João Carlos
; Coutinho, Henrique Madureira da Rocha
; Kikuta, Gustavo
; Almeida, Zely Sant'Anna Marotti de
; Feguri, Gibran Roder
; Lima, Paulo Ruiz Lucio de
; Franco, Anna Carolina
; Borges, Danilo de Cerqueira
; Cruz, Felipe Ramos Honorato De La
; Croti, Ulisses Alexandre
; Borim, Bruna Cury
; Marchi, Carlos Henrique De
; Goraieb, Lilian
; Postigo, Karolyne Barroca Sanches
; Jucá, Fabiano Gonçalves
; Oliveira, Fátima Rosane de Almeida
; Souza, Rafael Bezerra de
; Zilli, Alexandre Cabral
; Mas, Raul Gaston Sanchez
; Bettiati Junior, Luiz Carlos
; Tranchesi, Ricardo
; Bertini Jr, Ayrton
; Franco, Leandro Vieira
; Fernandes, Priscila
; Oliveira, Fabiana
; Moraes Jr, Roberto
; Araújo, Thiago Cavalcanti Vila Nova de
; Braga, Otávio Penna
; Pedrosa Sobrinho, Antônio Cavalcanti
; Teixeira, Roberta Tavares Barreto
; Camboim, Irla Lavor Lucena
; Gomes, Eduardo Nascimento
; Reis, Pedro Horigushi
; Garcia, Luara Piovan
; Scorsioni, Nelson Henrique Goes
; Lago, Roberto
; Guizilini, Solange
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Brazilian Journal of Cardiovascular Surgery
- Journal Metrics
Abstract Introduction: We investigated the clinical course and outcomes of patients submitted to cardiovascular surgery in Brazil and who had developed symptoms/signs of coronavirus disease 2019 (COVID-19) in the perioperative period. Methods: A retrospective multicenter study including 104 patients who were allocated in three groups according to time of positive real time reverse transcriptase-polymerase chain reaction (RT-PCR) for the SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2): group 1, patients who underwent cardiac surgery > 10 days after positive RT-PCR; group 2, patients with a positive RT-PCR within 10 days before or after surgery; group 3, patients who presented positive RT-PCR > 10 days after surgery. The primary outcome was mortality and secondary outcomes were postoperative complications, intensive care unit (ICU) length of stay, and postoperative days of hospitalization. Results: The three groups were similar with respect to age, the European System of Cardiac Operative Risk Evaluation score, and comorbidities, except hypertension. Postoperative complications and death were significantly higher in groups 2 and 3 than in group 1, and no significant difference between groups 2 and 3 was seen. Group 2 showed a high prevalence of surgery performed as an urgent procedure. Although no significant differences were observed in ICU length of stay, total postoperative hospitalization time was significantly higher in group 3 than in groups 1 and 2. Conclusion: COVID-19 affecting the postoperative period of patients who underwent cardiovascular surgery is associated with a higher rate of morbidity and mortality. Delaying procedures in RT-PCR-positive patients may help reduce risks of perioperative complications and death.
7.
BRAZILIAN GASTRIC CANCER ASSOCIATION GUIDELINES (PART 2): UPDATE ON TREATMENT
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BARCHI, Leandro Cardoso
; RAMOS, Marcus Fernando Kodama Pertille
; DIAS, André Roncon
; FORONES, Nora Manoukian
; CARVALHO, Marineide Prudêncio de
; CASTRO, Osvaldo Antonio Prado
; KASSAB, Paulo
; COSTA-JÚNIOR, Wilson Luiz da
; WESTON, Antônio Carlos
; ZILBERSTEIN, Bruno
; Ferraz, Álvaro Antônio Bandeira
; ZeideCharruf, Amir
; Brandalise, André
; Silva, André Maciel da
; Alves, Barlon
; Marins, Carlos Augusto Martinez
; Malheiros, Carlos Alberto
; Leite, Celso Vieira
; Bresciani, Claudio José Caldas
; Szor, Daniel
; Mucerino, Donato Roberto
; Wohnrath, Durval R.
; JirjossIlias, Elias
; Martins Filho, Euclides Dias
; PinatelLopasso, Fabio
; Coimbra, Felipe José Fernandez
; Felippe, Fernando E. Cruz
; Tomasisch, Flávio Daniel Saavedra
; Takeda, Flavio Roberto
; Ishak, Geraldo
; Laporte, Gustavo Andreazza
; Silva, Herbeth José Toledo
; Cecconello, Ivan
; Rodrigues, Joaquim José Gama
; Grande, José Carlos Del
; Lourenço, Laércio Gomes
; Motta, Leonardo Milhomem da
; Ferraz, Leonardo Rocha
; Moreira, Luis Fernando
; Lopes, Luis Roberto
; Toneto, Marcelo Garcia
; Mester, Marcelo
; Rodrigues, Marco Antônio Gonçalves
; Franciss, Maurice Youssef
; AdamiAndreollo, Nelson
; Corletta, Oly Campos
; Yagi, Osmar Kenji
; Malafaia, Osvaldo
; Assumpção, Paulo Pimentel
; Savassi-Rocha, Paulo Roberto
; Colleoni Neto, Ramiro
; Oliveira, Rodrigo Jose de
; AissarSallun, Rubens Antonio
; Weschenfelder, Rui
; Oliveira, Saint Clair Vieira de
; Abreu, Thiago Boechat de
; Castria, Tiago Biachi de
; Ribeiro Junior, Ulysses
; Barra, Williams
; Freitas Júnior, Wilson Rodrigues de
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ABCD. Arquivos Brasileiros de Cirurgia Digestiva (São Paulo)
- Journal Metrics
RESUMO Racional: O II Consenso Brasileiro de Câncer Gástrico da Associação Brasileira de Câncer Gástrico ABCG (Parte 1) foi recentemente publicado. Nesta ocasião inúmeros especialistas que atuam no tratamento desta doença expressaram suas opiniões diante declarações apresentadas. Objetivo: Apresentar as Diretrizes da ABCG (Parte 2) quanto às indicações de tratamento cirúrgico, técnicas operatórias, extensão de ressecção e terapia combinada. Métodos: Para formulação destas diretrizes os autores realizaram extensa e atual revisão referente a cada declaração presente no II Consenso, utilizando as bases Medline/PubMed, Cochrane Library e SciELO, inicialmente com os seguintes descritores: câncer gástrico, gastrectomia, linfadenectomia, terapia combinada. Ainda, cada declaração foi classificada de acordo com o nível de evidência e grau de recomendação. Resultados: Das 43 declarações presentes neste estudo, 11 (25,6%) foram classificadas com nível de evidência A, 20 (46,5%) B e 12 (27,9%) C. Quanto ao grau de recomendação, 18 (41,9%) declarações obtiveram grau de recomendação 1, 14 (32,6%) 2a, 10 (23,3%) 2b e um (2,3%) 3. Conclusão: O complemento das diretrizes aqui presentes possibilita que cirurgiões e oncologistas que atuam no combate ao câncer gástrico possam oferecer o melhor tratamento possível, de acordo com as condições locais disponíveis.
ABSTRACT Background : The II Brazilian Consensus on Gastric Cancer of the Brazilian Gastric Cancer Association BGCA (Part 1) was recently published. On this occasion, countless specialists working in the treatment of this disease expressed their opinion in the face of the statements presented. Aim : To present the BGCA Guidelines (Part 2) regarding indications for surgical treatment, operative techniques, extension of resection and multimodal treatment. Methods: To formulate these guidelines, the authors carried out an extensive and current review regarding each declaration present in the II Consensus, using the Medline/PubMed, Cochrane Library and SciELO databases initially with the following descriptors: gastric cancer, gastrectomy, lymphadenectomy, multimodal treatment. In addition, each statement was classified according to the level of evidence and degree of recommendation. Results : Of the 43 statements present in this study, 11 (25,6%) were classified with level of evidence A, 20 (46,5%) B and 12 (27,9%) C. Regarding the degree of recommendation, 18 (41,9%) statements obtained grade of recommendation 1, 14 (32,6%) 2a, 10 (23,3%) 2b e one (2,3%) 3. Conclusion : The guidelines complement of the guidelines presented here allows surgeons and oncologists who work to combat gastric cancer to offer the best possible treatment, according to the local conditions available.
https://doi.org/10.1590/0102-672020210001e1563
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8.
The first notosuchian crocodyliform from the Araçatuba Formation (Bauru Group, Paraná Basin), and diversification of sphagesaurians
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PINHEIRO, ANDRÉ EDUARDO P.
; SOUZA, LUCY G. DE
; BANDEIRA, KAMILA L.N.
; BRUM, ARTHUR S.
; PEREIRA, PAULO VICTOR LUIZ G.C.
; CASTRO, LUÍS OTÁVIO R. DE
; RAMOS, RENATO R.C.
; SIMBRAS, FELIPE M.
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Abstract The mesoeucrocodylian record from the Bauru Group (Paraná Basin, Brazil) comes from three formations: Adamantina (Late Turonian–Early Maastrichtian), Presidente Prudente (Early Campanian–Early Maastrichtian) and Marília (Maastrichtian). These records are restricted to the Early Coniacian–Early Maastrichtian. Here, we report a new crocodyliform record from the Bauru Group, which was the first of the Araçatuba Formation, from a new locality of Coronel Goulart district, in Álvares Machado municipality. Coronelsuchus civali gen. nov. et sp. nov. comprises two related specimens - FFP PG 13 and FFP PG 14 recovered close to each other and on the same muddy sandstone level. We perform a phylogenetic analysis with 392 characters (five new added) and 88 taxa. Our analyses supported the new clades: Sphagesauria, Sphagesaurinae and Caipirasuchinae. Our phylogenetic results suggest C. civali as a basal Sphagesauria. Regarding the Crocodyliform Assemblage Zones (CAZ), the new species is correlated to the CAZ 1, together with small sphagesaurians, Caryonosuchus and itasuchids. The C. civali reveals an older appearing (pre-Turonian) and diversification of Sphagesauria. The specimens also expand the stratigraphic range for Notosuchia in the Bauru Group.
https://doi.org/10.1590/0001-3765202120201591
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9.
II BRAZILIAN CONSENSUS ON GASTRIC CANCER BY THE BRAZILIAN GASTRIC CANCER ASSOCIATION
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BARCHI, Leandro Cardoso
; RAMOS, Marcus Fernando Kodama Pertille
; DIAS, André Roncon
; ANDREOLLO, Nelson Adami
; WESTON, Antônio Carlos
; LOURENÇO, Laércio Gomes
; MALHEIROS, Carlos Alberto
; KASSAB, Paulo
; ZILBERSTEIN, Bruno
; Ferraz, Álvaro Antônio Bandeira
; Charruf, Amir Zeide
; Brandalise, André
; Silva, André Maciel da
; Alves, Barlon
; Marins, Carlos Augusto Martinez
; Leite, Celso Vieira
; Bresciani, Claudio José Caldas
; Szor, Daniel
; Mucerino, Donato Roberto
; Wohnrath, Durval R.
; Ilias, Elias Jirjoss
; Martins Filho, Euclides Dias
; Lopasso, Fabio Pinatel
; Coimbra, Felipe José Fernandez
; Felippe, Fernando E. Cruz
; Tomasisch, Flávio Daniel Saavedra
; Takeda, Flavio Roberto
; Ishak, Geraldo
; Laporte, Gustavo Andreazza
; Silva, Herbeth José Toledo
; Cecconello, Ivan
; Rodrigues, Joaquim José Gama
; Grande, José Carlos Del
; Motta, Leonardo Milhomem da
; Ferraz, Leonardo Rocha
; Moreira, Luis Fernando
; Lopes, Luis Roberto
; Toneto, Marcelo Garcia
; Mester, Marcelo
; Rodrigues, Marco Antônio Gonçalves
; Carvalho, Marineide Prudêncio de
; Franciss, Maurice Youssef
; Forones, Nora Manoukian
; Corletta, Oly Campos
; Yagi, Osmar Kenji
; Castro, Osvaldo Antonio Prado
; Malafaia, Osvaldo
; Assumpção, Paulo Pimentel
; Savassi-Rocha, Paulo Roberto
; Colleoni Neto, Ramiro
; Oliveira, Rodrigo Jose de
; Sallun, Rubens Antonio Aissar
; Weschenfelder, Rui
; Oliveira, Saint Clair Vieira de
; Abreu, Thiago Boechat de
; Castria, Tiago Biachi de
; Ribeiro Junior, Ulysses
; Barra, Williams
; Costa Júnior, Wilson Luiz da
; Freitas Júnior, Wilson Rodrigues de
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ABCD. Arquivos Brasileiros de Cirurgia Digestiva (São Paulo)
- Journal Metrics
RESUMO Racional: Desde a publicação do primeiro Consenso Brasileiro sobre Câncer Gástrico em 2012 realizado pela Associação Brasileira de Câncer Gástrico (ABCG), novos conceitos sobre o diagnóstico, estadiamento, tratamento e seguimento foram incorporados. Objetivo: Promover uma atualização aos profissionais que atuam no combate ao câncer gástrico (CG) e fornecer diretrizes quanto ao manejo dos pacientes portadores desta afecção. Métodos: Cinquenta e nove especialistas responderam 67 declarações sobre o diagnóstico, estadiamento, tratamento e prognóstico do CG com cinco alternativas possíveis: 1) concordo plenamente; 2) concordo parcialmente; 3) indeciso; 4) discordo e 5) discordo fortemente. Foi considerado consenso a concordância de pelo menos 80% da soma das respostas “concordo plenamente” e “concordo parcialmente”. Este artigo apresenta apenas as respostas dos especialistas participantes. Os comentários sobre cada declaração, assim como uma revisão da literatura serão apresentados em publicações futuras. Resultados: Das 67 declarações, houve consenso em 50 (74%). Em 10 declarações, houve concordância de 100%. Conclusão: O tratamento do câncer gástrico evoluiu consideravelmente nos últimos anos. Este consenso reúne princípios consolidados nas últimas décadas, novos conhecimentos adquiridos recentemente, assim como perspectivas promissoras sobre o manejo desta doença.
ABSTRACT Background: Since the publication of the first Brazilian Consensus on Gastric Cancer (GC) in 2012 carried out by the Brazilian Gastric Cancer Association, new concepts on diagnosis, staging, treatment and follow-up have been incorporated. Aim: This new consensus is to promote an update to professionals working in the fight against GC and to provide guidelines for the management of patients with this condition. Methods: Fifty-nine experts answered 67 statements regarding the diagnosis, staging, treatment and prognosis of GC with five possible alternatives: 1) fully agree; 2) partially agree; 3) undecided; 4) disagree and 5) strongly disagree A consensus was adopted when at least 80% of the sum of the answers “fully agree” and “partially agree” was reached. This article presents only the responses of the participating experts. Comments on each statement, as well as a literature review, will be presented in future publications. Results: Of the 67 statements, there was consensus in 50 (74%). In 10 declarations, there was 100% agreement. Conclusion: The gastric cancer treatment has evolved considerably in recent years. This consensus gathers consolidated principles in the last decades, new knowledge acquired recently, as well as promising perspectives on the management of this disease.
https://doi.org/10.1590/0102-672020190001e1514
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10.
Explorando problemas arqueológicos com técnicas físico-químicas: a trajetória do Grupo de Estudos Arqueométricos do Instituto de Pesquisas Energéticas e Nucleares, São Paulo, Brasil
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Munita, Casimiro S
; Batalla, Nicolás
; Costa, Angislaine Freitas
; Barros, Joanna F.
; Nogueira, André Luiz
; Carvalho, Patrícia R.
; Carvalho, Priscilla Ramos
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Boletim do Museu Paraense Emílio Goeldi. Ciências Humanas
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Resumo O presente artigo traz uma revisão da principal literatura produzida pelo Grupo de Estudos Arqueométricos do Instituto de Pesquisas Energéticas e Nucleares, Comissão Nacional de Energia Nuclear, de São Paulo (IPEN-CNEN/SP), criado em 1997, como consequência de uma iniciativa internacional para motivar o uso de técnicas nucleares para caracterização de materiais arqueológicos. Desde aquele momento, e até hoje, o grupo tem desenvolvido parcerias com pesquisadores/as de diferentes regiões do Brasil e de outros países para oferecer subsídios à compreensão interdisciplinar das cadeias operatórias de produção da cerâmica. Além disso, também vem aportando dados para o estudo multielementar e mineralógico de depósitos arqueológicos. Ao descrever brevemente os princípios das técnicas empregadas e a síntese dos resultados obtidos para cada estudo de caso, o objetivo foi demonstrar a contribuição das análises físico-químicas para questões relacionadas a aspectos culturais, como escolhas tecnológicas compartilhadas, redes de trocas e interações sociais em diferentes períodos do passado.
Abstract The present paper brings together key literature produced by the Group of Archaeometric Studies of the Nuclear and Energy Research Institute, IPEN – National Nuclear Energy Commission (São Paulo, Brazil). This group was founded in 1997, as a result of an international initiative to encourage the use of nuclear techniques for the characterization of archaeological materials. Since then, the Group has developed interdisciplinary partnerships with researchers from Brazil and other countries to offer analytical tools for unraveling ceramic chaîne opératoires in different contexts. Such studies have contributed towards wider cultural interpretations regarding shared technological choices and artifact exchange networks in different social groups. Recently, the Group has also used multi-elemental and mineralogical techniques to tackle questions over the formation of archaeological deposits. This paper briefly explains the analytical principles of the employed techniques, and emphasizes how the results of each case study contribute to the interpretation of specific archaeological problems.
https://doi.org/10.1590/2178-2547-bgoeldi-2020-0004
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11.
BRAZILIAN GASTRIC CANCER ASSOCIATION GUIDELINES (PART 1): AN UPDATE ON DIAGNOSIS, STAGING, ENDOSCOPIC TREATMENT AND FOLLOW-UP
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BARCHI, Leandro Cardoso
; RAMOS, Marcus Fernando Kodama Pertille
; YAGI, Osmar Kenji
; MUCERINO, Donato Roberto
; BRESCIANI, Claudio José Caldas
; RIBEIRO JÚNIOR, Ulysses
; ANDREOLLO, Nelson Adami
; ASSUMPÇÃO, Paulo Pimentel
; WESTON, Antônio Carlos
; COLLEONI NETO, Ramiro
; ZILBERSTEIN, Bruno
; Ferraz, Álvaro Antônio Bandeira
; Charruf, Amir Zeide
; Dias, André Roncon
; Brandalise, André
; Silva, André Maciel da
; Alves, Barlon
; Malheiros, Carlos Alberto
; Marins, Carlos Augusto Martinez
; Leite, Celso Vieira
; Szor, Daniel
; Wohnrath, Durval R.
; Ilias, Elias Jirjoss
; Martins Filho, Euclides Dias
; Lopasso, Fabio Pinatel
; Coimbra, Felipe José Fernandez
; Felippe, Fernando E. Cruz
; Tomasisch, Flávio Daniel Saavedra
; Takeda, Flavio Roberto
; Ishak, Geraldo
; Laporte, Gustavo Andreazza
; Silva, Herbeth José Toledo
; Cecconello, Ivan
; Rodrigues, Joaquim José Gama
; Grande, José Carlos Del
; Lourenço, Laércio Gomes
; Motta, Leonardo Milhomem da
; Ferraz, Leonardo Rocha
; Moreira, Luis Fernando
; Lopes, Luis Roberto
; Toneto, Marcelo Garcia
; Mester, Marcelo
; Rodrigues, Marco Antônio Gonçalves
; Carvalho, Marineide Prudêncio de
; Franciss, Maurice Youssef
; Forones, Nora Manoukian
; Corletta, Oly Campos
; Castro, Osvaldo Antonio Prado
; Malafaia, Osvaldo
; Kassab, Paulo
; Savassi-Rocha, Paulo Roberto
; Oliveira, Rodrigo Jose de
; Sallun, Rubens Antonio Aissar
; Weschenfelder, Rui
; Oliveira, Saint Clair Vieira de
; Abreu, Thiago Boechat de
; Castria, Tiago Biachi de
; Barra, Williams
; Costa Júnior, Wilson Luiz da
; Freitas Júnior, Wilson Rodrigues de
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ABCD. Arquivos Brasileiros de Cirurgia Digestiva (São Paulo)
- Journal Metrics
RESUMO Racional: O II Consenso Brasileiro de Câncer Gástrico da Associação Brasileira de Câncer Gástrico (ABCG) foi recentemente publicado. Nesta ocasião, inúmeros especialistas que atuam no tratamento desta doença expressaram sua opinião diante declarações apresentadas. Objetivo: Apresentar as Diretrizes da ABCG (Parte 1) quanto ao diagnóstico, estadiamento, tratamento endoscópico e seguimento dos pacientes com câncer gástrico. Métodos: Para formulação destas Diretrizes os autores realizaram extensa e atual revisão referente a cada declaração presente no II Consenso, utilizando as bases Medline/PubMed, Cochrane Library e SciELO com os seguintes descritores: câncer gástrico, estadiamento, tratamento endoscópico e seguimento. Ainda, cada declaração foi classificada de acordo com o nível de evidência e grau de recomendação. Resultados: Das 24 declarações, duas (8,3%) foram classificadas com nível de evidência A, 11 (45,8%) B e 11 (45,8%) C. Quanto ao grau de recomendação, seis (25%) declarações obtiveram grau de recomendação 1, nove (37,5%) grau 2a, seis (25%) 2b e três (12,5%) 3. Conclusão: As diretrizes aqui presentes têm a finalidade de auxiliar os profissionais que atuam no combate ao câncer gástrico com informações relevantes e atuais, permitindo que sejam aplicadas na prática médica diária.
ABSTRACT Background: The II Brazilian Consensus on Gastric Cancer by the Brazilian Gastric Cancer Association (ABCG) was recently published. On this occasion, several experts in gastric cancer expressed their opinion before the statements presented. Aim: To present the ABCG Guidelines (part 1) regarding the diagnosis, staging, endoscopic treatment and follow-up of gastric cancer patients. Methods: To forge these Guidelines, the authors carried out an extensive and current review regarding each statement present in the II Consensus, using the Medline/PubMed, Cochrane Library and SciELO databases with the following descriptors: gastric cancer, staging, endoscopic treatment and follow-up. In addition, each statement was classified according to the level of evidence and degree of recommendation. Results: Of the 24 statements, two (8.3%) were classified with level of evidence A, 11 (45.8%) with B and 11 (45.8%) with C. As for the degree of recommendation, six (25%) statements obtained grade of recommendation 1, nine (37.5%) recommendation 2a, six (25%) 2b and three (12.5%) grade 3. Conclusion: The guidelines presented here are intended to assist professionals working in the fight against gastric cancer with relevant and current information, granting them to be applied in the daily medical practice.
https://doi.org/10.1590/0102-672020200003e1535
2100 downloads
12.
Vertical social distancing policy is ineffective to contain the COVID-19 pandemic
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Duczmal, Luiz Henrique
; Almeida, Alexandre Celestino Leite
; Duczmal, Denise Bulgarelli
; Alves, Claudia Regina Lindgren
; Magalhães, Flávia Costa Oliveira
; Lima, Max Sousa de
; Silva, Ivair Ramos
; Takahashi, Ricardo Hiroshi Caldeira
.
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Resumo: O artigo demonstra através de simulações numéricas que a política do chamado distanciamento social vertical é ineficaz para conter a pandemia da COVID-19. Os autores apresentam o modelo SEIR-Net para uma rede de interações entre grupos sociais, enquanto desdobramento do modelo matemático clássico para epidemias, chamado SEIR (Suscetíveis-Expostos-Infectados (sintomáticos e assintomáticos)-Removidos). No modelo SEIR-Net, pode-se simular contatos sociais entre grupos, divididos por faixas etárias, e analisar diferentes estratégias de distanciamento social. Na política de distanciamento vertical, apenas os idosos ficam distanciados, ao contrário da política de distanciamento horizontal, em que todas as faixas etárias aderem ao distanciamento. O artigo compara esses dois cenários a um cenário controle, sem nenhuma intervenção para distanciar as pessoas umas das outras. O cenário do distanciamento vertical é quase tão ruim quanto aquele sem nenhum distanciamento, em termos tanto do número de infectados quanto da aceleração do número de casos. Por outro lado, o distanciamento horizontal, desde que aplicado com a mesma intensidade a todos os grupos etários, reduz significativamente o número total de infectados e “achata a curva de crescimento da doença”. Nossa análise foi feita no Município de Belo Horizonte, Minas Gerais, Brasil, mas conclusões semelhantes se aplicam igualmente a outras cidades. O material suplementar do artigo fornece detalhes sobre a implementação do código do modelo na linguagem R.
Abstract: Considering numerical simulations, this study shows that the so-called vertical social distancing health policy is ineffective to contain the COVID-19 pandemic. We present the SEIR-Net model, for a network of social group interactions, as a development of the classic mathematical model of SEIR epidemics (Susceptible-Exposed-Infected (symptomatic and asymptomatic)-Removed). In the SEIR-Net model, we can simulate social contacts between groups divided by age groups and analyze different strategies of social distancing. In the vertical distancing policy, only older people are distanced, whereas in the horizontal distancing policy all age groups adhere to social distancing. These two scenarios are compared to a control scenario in which no intervention is made to distance people. The vertical distancing scenario is almost as bad as the control, both in terms of people infected and in the acceleration of cases. On the other hand, horizontal distancing, if applied with the same intensity in all age groups, significantly reduces the total infected people “flattening the disease growth curve”. Our analysis considers the city of Belo Horizonte, Minas Gerais State, Brazil, but similar conclusions apply to other cities as well. Code implementation of the model in R-language is provided in the supplementary material.
Demostramos mediante simulaciones numéricas que la denominada política de salud de aislamiento social vertical es ineficaz para contener la pandemia de COVID-19. Presentamos el modelo SEIR-Net para interacciones de grupo en una red social, como una evolución del clásico modelo matemático SEIR epidemics (Susceptibles-Expuestos-Infectados (sintomáticos y asintomáticos)-Removidos). En el modelo SEIR-Net, podemos simular contactos sociales entre grupos divididos por grupos de edad y analizar diferentes estrategias de distanciamiento social. En la política de aislamiento vertical, solamente se aísla a los ancianos, frente a la política de aislamiento horizontal, donde todos los grupos de edad se adhieren al aislamiento social. Estos dos escenarios se compararon a un escenario de control, en el que no se realiza ninguna intervención para aislar a la gente. El escenario de aislamiento vertical es casi tan malo, como el escenario donde no se aplica ningún tipo de aislamiento, tanto en términos del número de infectados, como en la aceleración del número de casos. Por otro lado, el aislamiento horizontal, si se aplica con la misma intensidad en todos los grupos de edad, reduce significativamente el número total de infectados y “aplana la curva de crecimiento de la enfermedad”. Nuestro análisis se realiza en la municipalidad de Belo Horizonte, Minas Gerais, Brasil, pero conclusiones similares se pueden aplicar también a otras ciudades. En el material complementario se facilita la implementación del código del modelo en R-language.
13.
Vertical social distancing policy is ineffective to contain the COVID-19 pandemic
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Duczmal, Luiz Henrique
; Almeida, Alexandre Celestino Leite
; Duczmal, Denise Bulgarelli
; Alves, Claudia Regina Lindgren
; Magalhães, Flávia Costa Oliveira
; Lima, Max Sousa de
; Silva, Ivair Ramos
; Takahashi, Ricardo Hiroshi Caldeira
.
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Resumo: O artigo demonstra através de simulações numéricas que a política do chamado distanciamento social vertical é ineficaz para conter a pandemia da COVID-19. Os autores apresentam o modelo SEIR-Net para uma rede de interações entre grupos sociais, enquanto desdobramento do modelo matemático clássico para epidemias, chamado SEIR (Suscetíveis-Expostos-Infectados (sintomáticos e assintomáticos)-Removidos). No modelo SEIR-Net, pode-se simular contatos sociais entre grupos, divididos por faixas etárias, e analisar diferentes estratégias de distanciamento social. Na política de distanciamento vertical, apenas os idosos ficam distanciados, ao contrário da política de distanciamento horizontal, em que todas as faixas etárias aderem ao distanciamento. O artigo compara esses dois cenários a um cenário controle, sem nenhuma intervenção para distanciar as pessoas umas das outras. O cenário do distanciamento vertical é quase tão ruim quanto aquele sem nenhum distanciamento, em termos tanto do número de infectados quanto da aceleração do número de casos. Por outro lado, o distanciamento horizontal, desde que aplicado com a mesma intensidade a todos os grupos etários, reduz significativamente o número total de infectados e “achata a curva de crescimento da doença”. Nossa análise foi feita no Município de Belo Horizonte, Minas Gerais, Brasil, mas conclusões semelhantes se aplicam igualmente a outras cidades. O material suplementar do artigo fornece detalhes sobre a implementação do código do modelo na linguagem R.
Abstract: Considering numerical simulations, this study shows that the so-called vertical social distancing health policy is ineffective to contain the COVID-19 pandemic. We present the SEIR-Net model, for a network of social group interactions, as a development of the classic mathematical model of SEIR epidemics (Susceptible-Exposed-Infected (symptomatic and asymptomatic)-Removed). In the SEIR-Net model, we can simulate social contacts between groups divided by age groups and analyze different strategies of social distancing. In the vertical distancing policy, only older people are distanced, whereas in the horizontal distancing policy all age groups adhere to social distancing. These two scenarios are compared to a control scenario in which no intervention is made to distance people. The vertical distancing scenario is almost as bad as the control, both in terms of people infected and in the acceleration of cases. On the other hand, horizontal distancing, if applied with the same intensity in all age groups, significantly reduces the total infected people “flattening the disease growth curve”. Our analysis considers the city of Belo Horizonte, Minas Gerais State, Brazil, but similar conclusions apply to other cities as well. Code implementation of the model in R-language is provided in the supplementary material.
Demostramos mediante simulaciones numéricas que la denominada política de salud de aislamiento social vertical es ineficaz para contener la pandemia de COVID-19. Presentamos el modelo SEIR-Net para interacciones de grupo en una red social, como una evolución del clásico modelo matemático SEIR epidemics (Susceptibles-Expuestos-Infectados (sintomáticos y asintomáticos)-Removidos). En el modelo SEIR-Net, podemos simular contactos sociales entre grupos divididos por grupos de edad y analizar diferentes estrategias de distanciamiento social. En la política de aislamiento vertical, solamente se aísla a los ancianos, frente a la política de aislamiento horizontal, donde todos los grupos de edad se adhieren al aislamiento social. Estos dos escenarios se compararon a un escenario de control, en el que no se realiza ninguna intervención para aislar a la gente. El escenario de aislamiento vertical es casi tan malo, como el escenario donde no se aplica ningún tipo de aislamiento, tanto en términos del número de infectados, como en la aceleración del número de casos. Por otro lado, el aislamiento horizontal, si se aplica con la misma intensidad en todos los grupos de edad, reduce significativamente el número total de infectados y “aplana la curva de crecimiento de la enfermedad”. Nuestro análisis se realiza en la municipalidad de Belo Horizonte, Minas Gerais, Brasil, pero conclusiones similares se pueden aplicar también a otras ciudades. En el material complementario se facilita la implementación del código del modelo en R-language.
https://doi.org/10.1590/0102-311x00084420
2716 downloads
14.
Estudo de enfermagem das propriedades térmicas da rede de dormir para prevenir úlcera por pressão
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Ramos, Ricardo Luiz
; Alves Machado, Wiliam Cesar
; Arias Torres, Dolly
; de Sousa Falcão, Ana Cristina
; de Sousa Velasque, Luciane
; Almeida de Figueiredo, Nébia Maria
.
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RESUMO Introdução: Pessoas acamadas estão susceptíveis as úlceras por pressão, embora as causas possam ser multifatoriais, a manutenção do microclima da pele constitui importante fator de prevenção dessas injúrias. Objetivo: Demonstrar as vantagens térmicas da Rede de dormir em relação ao Colchão hospitalar. Métodos: Experimental com seres humanos, amostra de 40 participantes, cada indivíduo foi seu próprio controle. O repouso em cada superfície de apoio foi de 30 minutos. Materiais: Colchão hospitalar D-28 revestido com capa em napa azul, Rede de dormir em algodão cru, termo higrômetro Minipa MT 242, termômetro digital infravermelho com mira laser e balança antropométrica. Para estatística utilizou-se Software R. Resultados: A temperatura de interface na Rd após os 15 minutos de repouso estabilizou na média de 1 ºC de elevação da temperatura inicial, no Colchão hospitalar ao término dos 30 minutos, a temperatura continuou em elevação, na média de 3 ºC. As variáveis não seguiram distribuição normal. O teste de Wilkoxon demonstrou diferença significativa para p<0,05. Conclusões: Demonstrou-se, em laboratório, que a Rede de dormir, em relação ao Colchão hospitalar, dissipa, significativamente, com maior eficiência o calor do corpo. O fato da Rede de dormir alterar minimamente um componente do microclima da pele sob pressão, fortalece a afirmativa que o seu uso contribui na prevenção da úlceras por pressão.
ABSTRACT Introduction: People bedridden are likely to Pressure Ulcers, although the causes may be multifactorial, the maintenance of the skin microclimate is an important factor for preventing these injuries. Objective: To demonstrate the advantages of thermal sleeping hammock in relation to the hospital mattress. Methods: Experimental with humans, sample of 40 participants, each individual has their own control. Resting on each support surface was 30 minutes. Methods: Hospital mattress D-28 coated with blue cover in nappa, sleeping hammock in raw cotton, thermo hygrometer Minipa MT 242, infrared digital thermometer with laser sight and anthropometric scale. Statistical software was used sleeping hammock. Results: The interface temperature at sleeping hammock after 15 minutes of rest stabilized average elevation of 1 °C initial temperature, at hospital mattress at the end of 30 minutes, the temperature continued to rise, the average of 3 °C. The variables did not follow normal distribution. The Wilkoxon test showed a significant difference at p <0.05. Conclusions: It has been demonstrated in the laboratory that sleeping hammock in relation to hospital mattress dissipates significantly more efficiently the heat of the body. The fact of sleeping hammock minimally change a microclimate component of the skin under pressure, strengthens the claim that their use contributes to the prevention of Pressure Ulcers.
RESUMEN Introducción: Las personas encamadas son susceptibles a úlceras por presión. Aunque las causas de estos padecimientos son multifactoriales, el mantenimiento del microclima de la piel constituye un factor importante de prevención. Objetivo: Demostrar las ventajas térmicas de la red de dormir en relación con el colchón hospitalario. Métodos: Estudio experimental con seres humanos. La muestra quedó conformada por 40 participantes; cada uno de ellos fue su propio control. El reposo en cada superficie de apoyo fue de 30 minutos. Materiales: colchón hospitalario D-28 revestido con capa impermeable azul; red en algodón 100 %-Minipa MT 242, termómetro laser digital infrarrojo y balanza antropométrica. Para el procesamiento estadístico se utilizó el software R. Resultados: La temperatura de interface en red de dormir, después de los 15 minutos de reposo, subió en promedio 1 °C con respecto a la temperatura inicial; en el colchón hospitalario, al término de los 30 minutos, la temperatura continuó elevándose con una media de 3 °C. Las variables no siguieron una distribución normal. El test de Wilkoxon demostró diferencia significativa con p<0,05. Conclusiones: Se demostró en prueba de laboratorio que la red disipa con mayor eficacia el calor del cuerpo. El que la red altere mínimamente un componente del microclima sobre la piel, confirma su utilidad en la prevención de úlceras por presión.
15.
Production of Furan Compounds from Sugarcane Bagasse Using a Catalytic System Containing ZnCl2/HCl or AlCl3/HCl in a Biphasic System
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In this work, two catalytic systems combining Lewis and Brønsted acids (ZnCl2/HCl and AlCl3/HCl) were applied in a tetrahydrofuran (THF)/NaClaq biphasic system to produce furan compounds from plant polysaccharides. The following cellulosic matrices were applied for this purpose: α-cellulose, microcrystalline cellulose and both native and steam-exploded sugarcane bagasse. The AlCl3/HCl catalytic system afforded the best yields for α-cellulose conversion to furan compounds (hydrolysis followed by dehydration). The highest yields of 5-(hydroxymethyl)-furfural (HMF) and furfural were 44.0 and 92.2% for AlCl3/HCl and 36.5 and 81.4% for ZnCl2/HCl, respectively. Cellulosic materials with lower crystallinity indexes afforded the best performance in hydrolysis followed by dehydration, giving relatively high yields of HMF and furfural. The HMF yields were similar for both native and steam-exploded sugarcane bagasse and the presence of lignin had a negative effect on HMF production. The highest furfural yield from native sugarcane bagasse was 60.6% with AlCl3/HCl catalytic system.
https://doi.org/10.21577/0103-5053.20180014
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