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ABSTRACT We present the experience of the Polyclinic of the Peruvian American Medical Society (PAMS) in Chincha, in the execution of medical educational missions in the Chincha region. The PAMS Polyclinic provides general and specialized medical care to the population of the area, six days a week. In addition, the Polyclinic receives medical missions generally coming from the EE.UU. Since 2011, we have received 43 medical missions. The composition and nature of the missions have changed over time. The first years attracted specialists with the emphasis on bringing equipment and supplies to improve the infrastructure of the Polyclinic. We are now limited by the reluctance of volunteers to come to Peru in part because the U.S. government considers travel to Peru to be high-risk. This limitation has given us the opportunity to do medical missions together with two excellent Peruvian universities. This experience has been positive.

RESUMEN Presentamos la experiencia del Policlínico de la Peruvian American Medical Society (PAMS) en Chincha, en la ejecución de misiones médico-educativas en la región Chincha. El Policlínico PAMS presta atención médica general y especializada a la población de la zona, seis días a la semana. Además, recibe misiones médicas que vienen generalmente de los EE. UU. Desde 2011, se han recibido 43 misiones médicas. La composición y la naturaleza de las misiones han cambiado con el tiempo. Los primeros años se atraía a especialistas con el énfasis de traer equipos e insumos para mejorar la infraestructura del Policlínico. Ahora estamos limitados por la renuencia de voluntarios de venir al Perú en parte debido a que el gobierno americano considera que viajes al Perú son de alto riesgo. Esta limitación nos ha brindado la oportunidad de hacer misiones médicas juntamente con dos excelentes universidades peruanas. La experiencia ha sido positiva.

https://doi.org/10.15381/anales.v85i1.27723

Deep sea ecosystem exploration and ‘health check’: sampling strategy and methods applied during the iAtlantic_BR10_Petrobras cruise in the Santos Basin, Southwest Atlantic health check check’ iAtlanticBR10Petrobras iAtlanticBRPetrobras iAtlantic BR10 Petrobras BR Basin iAtlanticBR BR1
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Perez, Jose Angel A.

; Barros Neto, Halésio M.C. de

; Arantes, Renata C.M.

; Gaurisas, Daniela Y.

; Silva, Camila F.

; Alves, Fernanda Maria M.

; Costa, Júlia A.

; Eloi, Paula D.C.

; Fonseca, Thayse S.

; Gavazzoni, Lucas

; Lonskis, Isabella da S.

; Nardi, Ricardo U.

; Nascimento, Pedro O.

; Rodrigues, João Vitor M.

; Santos, Ana Lara F. dos

; Santos, Edson C. dos

; Schroeder, Rafael

; Silva, Luis Carlos da

; Souza, Fernanda dos S.S. de

; Bernardino, Ângelo F.

; Cavalcanti, Guarani H.

; Lindner, Alberto

; Mahiques, Michel M. de

; Millo, Christian

; Reis, Priscila

; Sweetman, Andrew K.

; Roberts, J. Murray

Ocean and Coastal Research

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2023, Volume 71 elocation e23046

Abstract: En | Text: En | PDF: En

Abstract The iAtlantic Project has established an international collaborative strategy to improve mapping and characterization of deep and open ocean ecosystems in understudied regions of the Atlantic and evaluate their health. In December 2022, the first iAtlantic expedition in the South Atlantic set off to map and explore seafloor ecosystems in the Santos Basin slope (200-1,000 m depths) in collaboration with the Petrobras ‘Santos Basin - Regional Characterization Project.’ The 17-day ‘iAtlantic_BR10-Petrobras’ cruise was conducted on board the research vessel NPqHOc Vital de Oliveira (Brazilian Navy) and performed (a) water column structure characterization, (b) seafloor morphology mapping, (c) description of benthic habitats and communities by seafloor imagery and biological/ geological sampling, and (d) ex-situ experiments to assess the functioning of sedimentary ecosystems and their responses to climate-related environmental changes. This study describes the rationale behind the iAtlantic_BR10-Petrobras cruise science plan, reports its sampling strategy and methods, and summarizes its collected data and preliminary results. health 2022 2001,000 2001000 200 1,000 1 000 (200-1,00 depths Project. 17day day 17 ‘iAtlantic_BR10Petrobras iAtlanticBR10Petrobras iAtlanticBRPetrobras ‘iAtlantic_BR10 BR10 BR ‘iAtlantic_BR10-Petrobras Brazilian Navy a (a b (b c (c biological d (d exsitu ex situ climaterelated climate related changes iAtlantic_BR10Petrobras iAtlantic_BR10 plan methods results 202 2001 2001,00 200100 20 1000 1,00 00 (200-1,0 BR10Petrobras iAtlanticBR iAtlanticBR10 ‘iAtlantic_BR1 BR1 iAtlantic_BR1 2001,0 20010 2 100 1,0 0 (200-1, BRPetrobras iAtlanticBR1 ‘iAtlantic_BR iAtlantic_BR 2001, 10 1, (200-1 (200- (200 (20 (2 (

https://doi.org/10.1590/2675-2824071.23069jaap

Rapid Identification of new isolates of Acidipropionibacterium acidipropionici by fluorescence in situ hybridization (FISH)
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Babot, Jaime Daniel

; Argañaraz-Martínez, Eloy

; Apella, María Cristina

; Chaia, Adriana Perez

Revista argentina de microbiología

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dec 2022, Volume 54 N. 4 Pages 51 - 60

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Abstract Acidipropionibacterium acidipropionici is widely used for many applications, suchas propionic acid production, cereal silage, and also as probiotic. Due to this plethora of appli-cations, new isolates of A. acidipropionici with improved features are being searched for. Thesenew isolates must be accurately identified, however, most approaches become expensive andtime-consuming when the number of isolates is high. On the contrary, fluorescence in situhybridization allows the affordable, reliable, and rapid identification of microorganisms in purecultures and environmental and medical samples. Therefore, the aim of this work was to applya fluorescent in situ hybridization probe for the reliable identification of new A. acidipropioniciisolates. To this end, probe Pap446, specific for A. acidipropionici, was validated by hybridiza-tion assays with strains of this species from different origins, other species of the same genusor family, and unrelated genera. Eight isolates with propionibacterium characteristics wereobtained from milk and feces of cows. Probe Pap446, hybridized only with isolates III and VI.The identity of these isolates was further confirmed by PCR using group and species-specificprimers for propionibacteria and 16S rDNA sequencing.

Resumen Acidipropionibacterium acidipropionici es ampliamente usada para diversas aplicaciones, como producción de ácido propiónico, ensilado de cereales y probiótico. Debido a esta variedad de aplicaciones, continuamente se buscan nuevos aislamientos de A. acidipropionici con características nuevas. Estos nuevos aislamientos deben ser identificados correctamente, pero la mayoría de las técnicas disponibles resultan costosas e insumen mucho tiempo cuando el número de aislamientos es elevado. Por el contrario, la hibridación fluorescente in situ permite una identificación barata, confiable y rápida de microorganismos en cultivos puros y en muestras ambientales y médicas. Por lo tanto, el objetivo de este trabajo fue la aplicación de una sonda oligonucleotídica en un protocolo de hibridación fluorescente in situ para la identificación confiable de nuevos aislamientos de A. acidipropionici. Con este fin, se validó la sonda Pap446, específica de A. acidipropionici mediante ensayos de hibridación con cepas de esta especie de diferente origen, otras especies del mismo género o familia, y géneros no relacionados. Se obtuvieron ocho aislamientos con características de propionibacterias a partir de leche y heces de vacas. La sonda Pap446, hibridó únicamente con los aislamientos III y VI. La identidad de estos aislamientos fue confirmada a través de PCR con cebadores específicos para propionibacterias y para A. acidipropionici, y mediante secuenciación del ADNr 16S.

https://doi.org/10.1016/j.ram.2022.02.006

Recomendaciones para el tratamiento de la amiloidosis AL
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Brulc, Erika B.

; Carretero, Marcelina

; Aguirre, María A.

; Negro, Agustina

; Ulacia, María D.

; Perez de Arenaza, Diego

; Villanueva, Eugenia

; Sáez, María S.

; Sorroche, Patricia

; Posadas Martínez, María L.

; Nucifora, Elsa M.

Medicina (Buenos Aires)

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sep 2022, Volume 82 N. 4 Pages 591 - 604

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

Resumen Introducción: La amiloidosis por cadenas livianas de inmunoglobulinas (AL) es una enfermedad poco frecuente. El tratamiento implica un desafío, justificado en parte por el compromiso sistémico y la evidencia científica escasa. Objetivos: Elaborar recomendaciones basadas en la evidencia que permitan realizar un adecuado tratamiento de pacientes con amiloidosis AL. Métodos: Se generó un listado de preguntas con formato PICO centradas en la efectividad y seguridad del tratamiento de la amiloidosis AL. Se realizó la búsqueda en PubMed, Cochrane y Epistemonikos. Los niveles de evidencia y los grados de recomendación se basaron en el sistema GRADE. Resultados: Se generaron 11 recomendaciones. En pacientes con amiloidosis AL seleccionados, se recomienda el trasplante autólogo de células progenitoras hematopoyéticas (TCPH) poste rior a una inducción con esquemas basados en bortezomib y el acondicionamiento con melfalán, ya que podría profundizar la respuesta hematológica, de órgano, su durabilidad y mejorar la supervivencia. En pacientes no elegibles para TCPH, se recomienda el tratamiento de primera línea con esquemas basados en bortezomib, dado que es probable que logre mayor tasa de respuesta hematológica, de órgano y mejore la supervivencia. En pacientes con contraindicación o inaccesibilidad al bortezomib, se recomienda el tratamiento con agentes alquilantes y corticoides, dado que es probable que logren la respuesta hematológica, de órgano y mejoren la supervivencia. Discusión: Estas recomendaciones de tratamiento se basan en la evidencia disponible y la ex periencia del panel de expertos, en un escenario de recursos disponibles limitados, acorde a los países en vías de desarrollo.

Abstract Introduction: Immunoglobulin light chain (AL) amyloidosis is a rare disease. Treatment is chal lenging, justified in part by systemic compromise and limited scientific evidence. Objectives: Develop evidence-based recommendations that allow adequate treatment of patients with amyloidosis AL. Methods: A list of PICO format questions focused on the effectiveness and safety of amyloidosis AL treatment was generated. PubMed, Cochrane and Epistemonikos were searched. The levels of evidence and grades of recommendation were based on the GRADE system. Results: 11 recommendations were generated. In selected patients with amyloidosis AL, autologous hematopoietic stem cell transplantation (ASCT) is recommended after induction with bortezomib-based regimens and conditioning with melphalan, since it could deepen the hematological and organ response, its durability and improve survival. In patients not eligible for ASCT, first-line treatment with bortezomib-based regimens is recommended, since it is likely to achieve a higher rate of hematological and organ response and improve survival. In patients with a contraindication or inaccessibility to bortezomib, treatment with alkylating agents and corticosteroids is recommended, since they are likely to achieve haematological and organ response and improve survival. Discussion: These treatment recommendations are based on the available evidence and the experience of the panel of experts, in a scenario of limited available resources, according to developing countries.

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HONGOS FORMADORES DE MICORRIZAS ARBUSCULARES EN CAÑA DE AZÚCAR Y SU RELACIÓN EN CALIDAD Y RENDIMIENTO DE PANELA
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Wilches Ortiz, Wilmar Alexander

; Ramírez Gómez, María Margarita

; Reyes Mendez, Laura Maria

; Perez Moncada, Urley Adrian

; Serralde Ordoñez, Diana Paola

; Peñaranda Rolón, Andrea Maria

Centro Azúcar

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sep 2022, Volume 49 N. 3 Pages 78 - 89

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

ABSTRACT Introduction: In Colombia, panela is an ancestral food obtained by concentration from the extraction of sugarcane juice. Arbuscular Mycorrhizal Fungi (AMF) help the exchange and mobility of nutrients by associating with plants, improving quality and yield in different production systems. Objective: To evaluate the effect of AMF inoculation in sugarcane cultivation on panela yield and quality. Materials and Methods: The study was carried out in Suaita, Santander, under a randomized complete block design, in triplicate with four treatments (T1: Acaulospora mellea, T2: Rhizophagus irregularis, T3: control 50% and T4: control 100% fertilization). The variables in sugarcane were maturity indexes and tons per hectare, and in panela yield, tons per hectare, conversion to panela, reducing sugars, total solids, pH, moisture, sucrose, and soluble phosphorus were determined. Results and Discussion: There were significant differences (P>0.05) in the maturity index with T2 and a higher content of reducing sugars in panela with T1, in the other variables, a benefit of the inoculation with respect to the controls was observed, being T2 the treatment with the highest values in production of stems.ha-1, tons of cane.ha-1; and T1 in conversion to panela, reducing sugars, soluble phosphorus and total solids. Conclusions: Interaction of R. irregularis and A. mellea with panela quality and yield was found, obtaining promising results for the use of these microorganisms to enhance the sustainability and competitiveness of sugarcane for panela.

RESUMEN Introducción: En Colombia la panela es un alimento ancestral obtenido por concentración a partir de extracción de jugos de la caña azucarera. Los Hongos Formadores de Micorrizas Arbusculares (HFMA) ayudan al intercambio y movilidad de nutrientes al asociarse con plantas, mejorando la calidad y rendimiento en diferentes sistemas productivos. Objetivo: Evaluar el efecto de la inoculación con HFMA en el cultivo de la caña de azúcar sobre el rendimiento y la calidad en panela. Materiales y Métodos: El estudio se desarrolló en Suaita, Santander, bajo un diseño de bloques completos al azar, por triplicado con cuatro tratamientos (T1: Acaulospora mellea, T2: Rhizophagus irregularis, T3: Control 50% y T4: Control 100% de fertilización). Las variables en caña fueron índices de madurez y toneladas por hectárea, y en panela se determinaron rendimiento, toneladas por hectárea, conversión a panela, azúcares reductores, sólidos totales, pH, humedad, sacarosa y fósforo soluble. Resultados y Discusión: Se presentaron diferencias significativas (P>0,05) en el índice de madurez con el T2 y mayor contenido de azúcares reductores en panela con el T1, en las demás variables se observó un beneficio de la inoculación respecto los controles, siendo T2 el tratamiento con valores altos en producción de tallos.ha-1, toneladas caña.ha-1; y T1 en conversión a panela, azúcares reductores, fósforo soluble y sólidos totales. Conclusiones: Se encontró interacción de R. irregularis y A. mellea con la calidad y rendimiento en panela, obteniéndose resultados prometedores del uso de estos microorganismos para potencializar la sostenibilidad y competitividad de la caña azucarera para panela.

Guía de tratamiento farmacológico específico de la cardiomiopatía amiloidótica por transtiretina, 2021
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Villanueva, Eugenia

; Carretero, Marcelina

; Aguirre, María A.

; Negro, Agustina

; Belziti, César A.

; Posadas-Martínez, María L.

; Nucifora, Elsa M.

; Baratta, Sergio

; Costabel, Juan P.

; Higa, Claudio

; Rivas, Carlos

; Fernández, Adrián

; Quiroga, Alejandro

; Dumont, Carlos A.

; Volberg, Verónica I.

; Streitenberg, Gisela M.

; Perez de Arenaza, Diego

Medicina (Buenos Aires)

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may 2022, Volume 82 N. 2 Pages 275 - 288

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

Resumen Con el propósito de confeccionar una guía con la mejor evidencia disponible en el tratamiento de la amiloidosis por depósito de transtiretina (ATTR), se generó un listado de preguntas en formato PICO centradas en la efectividad y seguridad y se realizó una búsqueda en PubMed, Cochrane y Epistemokus de los artículos publicados entre 2000-2020 y se incluyeron dos estudios de extensión en relación al tafamidis. Los niveles de evidencia y los grados de recomendación se basaron en el sistema GRADE, emitiéndose 11 recomendaciones para ATTRv y ATTwt. Se consideraron los siguientes fármacos: tafamidis, diflunisal, inotersen, patisiran y doxiciclina más ácido ursodesoxicolico. El grupo de expertos consensuó que el único tratamiento que demostró reducir de la mortalidad global, mortalidad cardiovascular, internaciones cardiovasculares y la progresión de la cardiopatía con un nivel moderado de evidencia fue el tafamidis 80 mg, mientras que para la formulación tafamidis 20 mg la calidad de evidencia es baja. Para inotersen y diflunisal, se formuló una recomendación en contra del tratamiento dada la falta de evidencia de calidad respecto a su efectividad, el perfil de toxicidad y la falta de disponibilidad en el ámbito local. Con respecto al patisirán, la recomendación se focalizó en la población ATTRv. El panel de expertos consensuó que el tratamiento con doxiciclina más ácido ursodeoxicólico podría ser utilizado ante la imposibilidad de iniciar tratamiento con tafamidis, recomendación débil y calidad de evidencia muy baja.

Abstract This clinical practice guideline for treating transthyretin amyloid (ATTR) cardiomyopathy is based on the best available evidence of clinical effectiveness. The PICO format was used to generate a list of ques tions focused on the effectiveness and safety of the specific treatment of patients with ATTR cardiomyopathy. The search was conducted in PubMed, Cochrane and Epistemokus, between July-August 2020, and selected articles between 2000-2020, in English and Spanish. The level of evidence and recommendations were analyzed and classified by the GRADE system. The following drugs were included in the analysis: tafamidis, diflunisal, inotersen, patisiran y doxycycline and ursodeoxycholic acid. The expert panel had an agreement that tafamidis 80mg/daily is the only available drug with moderate evidence and weak recommendation for the reduction of total mortality, cardiovascular morbidity, heart failure hospitalization and progression of the disease in patients with ATTR cardiomyopathy and NYHA class ≤ 3. In contrast, tafamidis 20 mg/daily had low-quality evidence in this group of patients. The expert panel did not recommend inotersen, patisiran and diflunisal in patients with ATTR cardiomyopathy due to the lack of supporting evidence, local drug availability, and the potential risk of toxicity. When patients did not have access to tafamidis, the expert panel stated a weak recommendation to use doxycycline and ursodeoxycholic acid in patients with ATTR cardiomyopathy.

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speciesLink: rich data and novel tools for digital assessments of biodiversity
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Canhos, Dora Ann Lange

; Almeida, Eduardo A. B.

; Assad, Ana Lucia

; Cunha Bustamante, Mercedes Maria da

; Canhos, Vanderlei Perez

; Chapman, Arthur David

; Giovanni, Renato De

; Imperatriz-Fonseca, Vera Lúcia

; Lohmann, Lúcia Garcez

; Maia, Leonor Costa

; Miller, Joseph T.

; Nelson, Gil

; Peterson, A. Townsend

; Pirani, José Rubens

; Souza, Sidnei de

; Stehmann, João Renato

; Thiers, Barbara

Biota Neotropica

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2022, Volume 22 N. spe elocation e20221394

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo speciesLink é um portal de informações em larga escala sobre biodiversidade, que existe graças a uma ampla rede colaborativa de pessoas e instituições. O envolvimento do CRIA com a comunidade científica do Brasil e de outros países é responsável pelos resultados expressivos alcançados, atingindo atualmente mais de 15 milhões de registros de dados primários de biodiversidade, sendo 95% associados a espécimes preservados e cerca de 25% a imagens digitais de alta qualidade. A rede fornece dados sobre mais de 200.000 espécies, das quais mais de 110.000 ocorrem no Brasil. Este artigo descreve as redes temáticas do speciesLink, bem como algumas das ferramentas mais úteis desenvolvidas. A importância e as contribuições do speciesLink são destacadas, assim como as preocupações em garantir um apoio financeiro estável para e-infraestruturas de dados sobre biodiversidade. Aqui revisamos o valor do speciesLink como uma das principais fontes de informação sobre biodiversidade para pesquisa, educação, tomada de decisão, desenvolvimento de políticas e bioeconomia.

Abstract speciesLink is a large-scale biodiversity information portal that exists thanks to a broad collaborative network of people and institutions. CRIA’s involvement with the scientific community of Brazil and other countries is responsible for the significant results achieved, currently reaching more than 15 million primary biodiversity data records, 95% of which are associated with preserved specimens and about 25% with high-quality digital images. The network provides data on over 200,000 species, of which over 110,000 occur in Brazil. This article describes thematic networks within speciesLink, as well as some of the most useful tools developed. The importance and contributions of speciesLink are outlined, as are concerns about securing stable budgetary support for such biodiversity data e-infrastructures. Here we review the value of speciesLink as a major source of biodiversity information for research, education, informed decision-making, policy development, and bioeconomy.

https://doi.org/10.1590/1676-0611-bn-2022-1394

Positive fluid balance as an early biomarker for acute kidney injury: a prospective study in critically ill adult patients
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Ávila, Maria Olinda Nogueira

; Rocha, Paulo Novis

; Perez, Caio A.

; Faustino, Tássia Nery

; Batista, Paulo Benigno Pena

; Yu, Luis

; Zanetta, Dirce Maria T.

; Burdmann, Emmanuel A.

Clinics

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2021, Volume 76 elocation e1924

Abstract: En | Text: En | PDF: En

OBJECTIVES: Positive fluid balance is frequent in critically ill patients and has been considered a potential biomarker for acute kidney injury (AKI). This study aimed to evaluate positive fluid balance as a biomarker for the early detection of AKI in critically ill patients. METHODS: This was a prospective cohort study. The sample was composed of patients ≥18 years old who stayed ≥3 days in an intensive care unit. Fluid balance, urinary output and serum creatinine were assessed daily. AKI was diagnosed by the Kidney Disease Improving Global Outcome criteria. RESULTS: The final cohort was composed of 233 patients. AKI occurred in 92 patients (40%) after a median of 3 (2-6) days following ICU admission. When fluid balance was assessed as a continuous variable, a 100-ml increase in fluid balance was independently associated with a 4% increase in the odds of AKI (OR 1.04; 95% CI 1.01-1.08). Positive fluid balance categorized using different thresholds was always significantly associated with subsequent detection of AKI. The mixed effects model showed that increased fluid balance preceded AKI by 4 to 6 days. CONCLUSION: These results suggest that a positive fluid balance might be an early biomarker for AKI development in critically ill patients.

https://doi.org/10.6061/clinics/2021/e1924 461 downloads

Self-perception, quality of life and ease of catheterization in patients with continent urinary diversion with the mitrofanoff principle
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Chavarriaga, Julián

; Fernández, Nicolás

; Campo, María A. O.

; Bolivar, John

; Patiño, German

; Perez, Jaime

International braz j urol

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oct 2020, Volume 46 N. 5 Pages 743 - 751

Abstract: En | Text: En | PDF: En

ABSTRACT Purpose: Continent urinary diversion (CUD) with the Mitrofanoff principle stands as an alternative to urethral catheterization by a route other than the urethra. The aim of the study was to determine self-perception of health-related quality of life (HRQoL), ease of catheterization and global and cosmetic outcomes in patient’s dependent on Mitrofanoff catheterization. Materials and methods: Records of all patients who underwent CUD with the Mitrofanoff principle between 2012 to 2018 were reviewed. Data were collected and analysed retrospectively from medical charts. We assessed HRQoL with the EuroQol EQ-5D-3L questionnaire, cosmetic and global satisfaction with a questionnaire designed by the reconstructive urology board and ease of catheterization with a Likert questionnaire adapted from the Intermittent Catheterization Difficulty Questionnaire (ICDQ) validated in patients reliant on retrograde CIC. Results: A total of 25 patients requiring CUD with the Mitrofanoff principle between 2012 and 2018 were assessed, the group was composed mainly of: appendiceal conduits 18 patients (72%) and 7 ileal conduits (Yang-Monti) and three of those requiring Casale (Monti Spiral) and 1 a double Monti technique. Median follow-up was 57 months, median age was 30 years. Visual Analogue Scale (VAS) of the EQ-5D-3L reported a Global health score of 86.5%. Fifty nine percent of the patients had no pain or bleeding with catheterizations. Regarding global satisfaction and cosmetic perception 91% were satisfied with their CUD. Conclusions: CUD is associated with good HRQoL, global satisfaction, ease and painless catheterization, adequate self-perception of cosmetic outcomes and a low complication rate, remaining a safe and viable option.

https://doi.org/10.1590/s1677-5538.ibju.2019.0388 633 downloads

10.

Caracterización bioarqueológica e isotópica de restos óseos humanos de un entierro del sitio tardío El Molino (Depto. Belén, Catamarca)
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Iucci, María Emilia

; Cobos, Virginia A.

; Moscardi, Bruno

; Perez, S. Ivan

Revista del Museo de Antropología

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aug 2020, Volume 13 N. 2 Pages 129 - 134

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Abstract The skeletal remains found in a structure excavated at the El Molino site, a Late Period prehispanic settlement located in the Hualfín Valley, are analyzed. The finding was made in a sector closed by a stone wall -pirca-, within a structure of dwelling characteristics, and constitutes one of the few examples of human remains of an adult individual properly contextualized and registered in the region. Bioarchaeological studies allowed us to determine that it is a female individual between 45 and 50 years old, with the presence of degenerative alterations of the joints, wear and dental pathologies, frequents in farmer human groups. The isotopic analysis was consistent with a diet based on lowland camelids and processed plant resources, possibly corn. The burial was dated to the 15th century, and is coherent with the majority of the late dates obtained in the valley.

Resumen Se analizan los restos esqueletales hallados en una estructura excavada en el sitio El Molino, un poblado prehispánico tardío localizado en el Valle de Hualfín. El hallazgo se realizó en un sector cerrado por una pirca, en el interior de un recinto de características habitacionales, y constituye uno de los escasos ejemplos de restos humanos de un individuo adulto adecuadamente contextualizado y registrado de la región. Los estudios bioarqueológicos permitieron determinar que se trata de un individuo femenino de entre 45 y 50 años, con presencia de alteraciones degenerativas de las articulaciones, desgaste y patologías dentales, frecuentes en grupos humanos agricultores. El análisis isotópico resultó consistente con una dieta basada en camélidos de regiones bajas y recursos vegetales procesados, posiblemente maíz. La realización de un fechado permite ubicar al entierro en el siglo XV, de manera análoga a la mayoría de fechados tardíos obtenidos en el valle.

https://doi.org/10.31048/1852.4826.v13.n2.27240 73 downloads

11.

Population growth of a generational cohort of the copepod Apocyclops panamensis (Marsh, 1913) under different temperatures and salinities
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Cruz-Rosado, Leonardo

; Contreras-Sánchez, Wilfrido M.

; Hernández-Vidal, Ulises

; Perez-Urbiola, Juan Carlos

; Contreras-García, María de J

Ecosistemas y recursos agropecuarios

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2020, Volume 7 N. 2 elocation e2505

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Abstract This study was carried out to identify the effects of salinity and temperature during Apocyclops panamensis culture, fed with Tetraselmis chuii. The experiment was conducted in laboratory conditions for 14 days. Nauplii from the same cohort were used to start the experiment, using a density of 1 ind mL -1 in a volume of 400 mL. The feed consisted of a daily supply of 20 000 cell mL -1 of microalgae. Nine treatments with three replicates were evaluated (24○ C-28‰, 24○ C-32‰, 24○ C-36‰, 28○ C-28‰, 28○ C-32‰, 28○ C-36‰, 32○ C-28‰, 32○ C- 32‰ and 32○ C-36‰). The factorial ANOVA indicates that temperature had a significant effect on the abundance of total copepods at day 14 (p = 0.02), while salinity did not show a significant effect (p = 0.06) on the total population of A. panamensis. Significant effects of temperature (p < 0.01) and salinity (p < 0.001) were observed for the nauplii population. The best growth of the entire population was reached in the treatment 32○ C-28‰, with a population of 1 380.95 (±1 267.06 ind L -1 (±1 267.06) at the end of the experiment. Treatments 32○ C-28‰ and 32○ C-32‰ produced the highest average population of nauplii and copepodites at the end of the experiment. Adult females presented the greatest abundance in the 32○ C-32‰ treatment with 214.29 ind L -1, adult males increased between days 11 and 14 in treatments 24○ C-28‰, 32○ C-28‰, and 32○ C-32‰ without exceeding 170 ind L -1. In this study, it is evident that A. panamensis prefers warm temperatures and brackish environments.

Resumen El objetivo del estudio fue identificar los efectos de la salinidad y la temperatura durante el cultivo de Apocyclops panamensis, alimentado con Tetraselmis chuii. El experimento se llevó a cabo en condiciones de laboratorio durante 14 días. Se utilizaron nauplios de una misma cohorte, utilizando una densidad de 1 ind mL -1 en un volumen de 400 mL. La alimentación consistió en un suministro diario de 20 000 células de microalga mL -1. Se evaluaron nueve tratamientos con tres réplicas (24○ C-28‰, 24○ C-32‰, 24○ C-36‰, 28○ C-28‰, 28○ C-32‰, 28○ C-36‰, 32○ C-28‰, 32○ C- 32‰ y 32○ C-36‰). El ANOVA factorial indica que la temperatura tuvo un efecto significativo en la abundancia de copépodos totales en el día 14 (p = 0.02), mientras que la salinidad no mostró un efecto significativo (p = 0.06) en la población total de A. panamensis. Se observaron efectos significativos de la temperatura (p < 0.01) y la salinidad (p < 0.001) en la población de nauplios. El mejor crecimiento de toda la población al final del experimento se alcanzó en el tratamiento 32○ C-28‰, con una población de 1 380.95±1 267.06 ind L -1. Los tratamientos 32○ C-28‰ y 32○ C-32‰ produjeron la mayor población promedio de nauplios y copepoditos al final del experimento. Las hembras adultas presentaron la mayor abundancia en el tratamiento 32○ C-32‰ con 214.29 ind L -1, los machos adultos aumentaron entre los días 11 y 14 en los tratamientos 24○ C-28‰, 32○ C-28‰, y 32○ C-32h sin exceder 170 ind L -1. Los resultados indican que A. panamensis prefiere las temperaturas cálidas y los ambientes salobres.

https://doi.org/10.19136/era.a7n2.2505 550 downloads

12.

Validación del M-CHAT-R/F como instrumento de tamizaje para detección precoz en niños con trastorno del espectro autista
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Coelho-Medeiros, María Elisa

; Bronstein, Jonathan

; Aedo, Karina

; Pereira, Jaime A.

; Arraño, Verónica

; Perez, Carolina A.

; Valenzuela, Patricia M.

; Moore, Rosario

; Garrido, Isabel

; Bedregal, Paula

Revista chilena de pediatría

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oct 2019, Volume 90 N. 5 Pages 492 - 499

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Abstract: Introduction: Screening for Autism Spectrum Disorders (ASD) using the Modified Checklist for Autism in Toddlers, Revised with Follow-up (M-CHAT-R/F) increases early detection, allowing early interventions and improving prognosis. This tool is part of the management in case of suspected ASD in several clinical guidelines. The objective of this article was to conduct the concurrent and discrimi nant validation and the reliability analysis of M-CHAT-R/F in the Chilean population. Patients and Method: This is the second stage of the cross-cultural adaptation of cross-sectional design. M-CHAT- R/F was applied to a sample of 20 children with suspected ASD and 100 randomly selected healthy control children, aged between 16-30 months. Autism Diagnostic Observation Schedule (ADOS-2), considered as reference, was applied to the 20 patients of the clinical sample, to 20 children of the healthy control sample and to those cases of the healthy control sample with M-CHAT-R/F positive. Cronbach alpha was calculated, as well as M-CHAT-R/F and ADOS-2 correlation, sensitivity, and specificity analyses. Results: In the healthy sample, M-CHAT-R/F was positive in two patients, with one of them positive and the other one negative for ASD with ADOS-2 test. In the clinical sample, M- CHAT-R/F was positive in all cases, three of them were negative in the ADOS-2 test. The Alfa relia bility of M-CHART-R/T was 0,889, the discriminant sensitivity and specificity were 100% and 98%, and the concurrent ones were 100% and 87.5% respectively. Conclusions: The Chilean M-CHAT- R/F version was reliable, sensitive and specific, similar to the original test, which opens the possibility for its use in clinical samples and for research. Validating M-CHAT-R/F is an ongoing process which must be further developed.

Resumen: Introducción: El tamizaje de los Trastornos del Espectro Autista (TEA) mediante el Modified Chec klist for Autism in Toddlers - Revised with Follow Up (M-CHAT-R/F) aumenta la detección precoz, posibilitando intervenciones tempranas y mejorando el pronóstico. Este instrumento es parte del algoritmo de manejo ante la sospecha de TEA en diversas guías clínicas. El objetivo fue realizar la validación concurrente, discriminante y el análisis de confiabilidad del M-CHAT-R/F en una pobla ción chilena. Pacientes y Método: Esta es la segunda etapa de la adaptación transcultural, de diseño transversal. Se aplicó M-CHAT-R/F a una muestra de 20 niños con sospecha de TEA y 100 niños de control sano seleccionados al azar, de 16-30 meses de edad. Se aplicó Autism Diagnostic Observation Schedule (ADOS-2), considerado como referencia, a los 20 pacientes de la muestra clínica, a 20 niños de la muestra de control sano y a aquellos casos de la muestra de control sano con M-CHAT-R/F po sitivo. Se calculó alfa de Cronbach, análisis de correlación de M-CHAT-R/F y ADOS-2 y sensibilidad y especificidad. Resultados: En el grupo de control sano, M-CHAT-R/F resultó alterado en 2 pacien tes, siendo uno positivo y otro negativo para TEA con ADOS-2. En muestra clínica el M-CHAT-R/F fue positivo en todos, con test de ADOS-2 negativo en 3 casos. La confiabilidad Alfa del M-CHAT- R/F fue =0,889, la sensibilidad y especificidad discriminante de 100 y 98% y la concurrente 100% y 87,5% respectivamente. Conclusión: M-CHAT-R/F en su versión chilena resultó fiable, sensible y específico de manera similar al original, lo cual abre la posibilidad de su utilización en población clínica y para investigación. La validación es un proceso continuo que se debe profundizar.

https://doi.org/10.32641/rchped.v90i5.703 7932 downloads

13.

ESTIMACIÓN DE LA EDAD DE GUANACO (LAMA GUANICOE) A PARTIR DE LOS DIENTES INCISIVOS: UN APORTE METODOLÓGICO PARA LA CONSTRUCCIÓN DE PERFILES DE MORTALIDAD
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Kaufmann, Cristian A.

; Álvarez, María Clara

; Perez, S. Ivan

Revista del Museo de Antropología

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jun 2017, Volume 10 N. 1 Pages 19 - 29

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

The guanaco was the main resource for hunter-gatherers that inhabited the Pampean and Patagonian regions of Argentina. This ungulate played a fundamental role in the economic, social, and ideological spheres of these societies during the Holocene. In this sense, understanding the relationship between human and guanaco populations in the past is crucial to South American zooarchaeology. The aim of this paper is to present a methodology that allows estimating the relative age of guanacos by analyzing their incisor teeth. The sample is composed of incisors from 91 modern guanacos assigned/attributed to different age-classes. This analysis included qualitative variables, such as root and dentine state, and quantitative ones, such as crown height. Results show that the combination of these variables is a useful indicator for estimating the age of guanacos from analysis of isolated incisors, usually found in the faunal record.

El guanaco fue el principal recurso para los cazadores-recolectores que habitaron las regiones pampeana y patagónica de Argentina. Este ungulado jugó un rol fundamental en la esfera económica, social e ideológica de estas sociedades durante el Holoceno. En este sentido, comprender la relación entre las poblaciones de humanos y guanacos en el pasado es crucial para la zooarquelogía sudamericana. El objetivo de este trabajo es presentar una metodología que permita estimar la edad relativa de los camélidos a partir del análisis de los dientes incisivos. La muestra se compone de incisivos de 91 guanacos modernos, asignados a diferentes clases de edad. Este análisis incluyó variables cualitativas, tales como el estado de la raíz y de la dentina, así como cuantitativas, como la altura de la corona. Los resultados indican que la combinación de estas variables es un indicador útil para la estimación de la edad en incisivos aislados de guanaco, los cuales son frecuentemente hallados en el registro faunístico.

262 downloads

14.

Effectiveness and safety of first-generation protease inhibitors in real-world patients with hepatitis C virus genotype 1 infection in Brazil: a multicenter study
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Callefi, Luciana Azevedo

; Villela-Nogueira, Cristiane Alves

; de Barros Tenore, Simone

; Carnaúba-Júnior, Dimas

; Coelho, Henrique Sérgio Moraes

; Pinto, Paulo de Tarso A.

; Nabuco, Letícia Cancella

; Pessoa, Mário Guimarães

; Ferraz, Maria Lucia Cardoso Gomes

; Ferreira, Paulo Roberto Abrão

; de Lourdes Candolo Martinelli, Ana

; Chachá, Silvana Gama Florencio

; de Souza Paiva Ferreira, Adalgisa

; de Macedo Bisio, Alessandra Porto

; Brandão-Mello, Carlos Eduardo

; Álvares-Da-Silva, Mário Reis

; Reuter, Tânia

; Ivantes, Claudia Alexandra Pontes

; de Mello Perez, Renata

; Mendes-Correa, Maria Cássia Jacintho

Clinics

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jun 2017, Volume 72 N. 6 Pages 378 - 385

Abstract: En | Text: En | PDF: En

OBJECTIVE: To evaluate the effectiveness and safety of first-generation protease inhibitors for the treatment of genotype 1 hepatitis C virus-infected patients at Brazilian reference centers. METHODS: This multicenter cross-sectional study included hepatitis C virus genotype 1 monoinfected patients treated with Peg-interferon, ribavirin, and either boceprevir (n=158) or telaprevir (n=557) between July 2013 and April 2014 at 15 reference centers in Brazil. Demographic, clinical, virological, and adverse events data were collected during treatment and follow-up. RESULTS: Of the 715 patients, 59% had cirrhosis and 67.1% were treatment-experienced. Based on intention-to-treat analysis, the overall sustained viral response was 56.6%, with similar effectiveness in both groups (51.9% for boceprevir and 58% for telaprevir, p=0.190). Serious adverse events occurred in 44.2% of patients, and six deaths (0.8%) were recorded. Cirrhotic patients had lower sustained viral response rates than non-cirrhotic patients (46.9% vs. 70.6%, p<0.001) and a higher incidence of serious adverse events (50.7% vs. 34.8%, p<0.001). Multivariate analysis revealed that sustained viral response was associated with the absence of cirrhosis, viral recurrence after previous treatment, pretreatment platelet count greater than 100,000/mm3, and achievement of a rapid viral response. Female gender, age>65 years, diagnosis of cirrhosis, and abnormal hemoglobin levels/platelet counts prior to treatment were associated with serious adverse events. CONCLUSION: Although serious adverse events rates were higher in this infected population, sustained viral response rates were similar to those reported for other patient cohorts.

https://doi.org/10.6061/clinics/2017(06)08 869 downloads

15.

Practical Considerations of Real Life of Hepatocellular Carcinoma in a Tertiary Center of Brazil
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Carvalho, Sandra R. Almeida

; Ferraz, Maria L. Gomes

; Matos, Carla A. Loureiro

; Silva, Antônio E. Benedito

; Filho, Roberto J. Carvalho

; Perez, Rogério Renato

; Gonzalez, Adriano Miziara

; Salzedas-Netto, Alcides A.

; Szejnfeld, Denis

; D’Ippolito, Giuseppe

; Lanzoni, Valéria Pereira

; Silva, Ivonete S. Souza

Annals of Hepatology

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apr 2017, Volume 16 N. 2 Pages 255 - 262

Abstract: En | Text: En | PDF: En

ABSTRACT Background. Hepatocellular carcinoma (HCC) is the most common malignancy that develops in cirrhotic livers. Its clinical and epidemiological characteristics and mortality rates vary according to geographical region. The objective of this study was to evaluate the clinical profile, epidemiological characteristics, laboratory parameters, treatment and survival of patients with HCC. Material and methods. Patients with HCC seen between 2000 and 2012 were studied. The Kaplan-Meier method was used for survival analysis according to variables in question. Results. The study included 247 patients with a mean age of 60 ± 10 years. There was a predominance of males (74%). The main etiologies of HCC were HCV infection (55%), excessive alcohol consumption (12%), and HBV infection (8%). Liver cirrhosis was present in 92% of cases. The mean tumor number and diameter were 2 and 5 cm, respectively. Patients meeting the Milan criteria corresponded to 43% of the sample. Liver transplantation was performed in 22.4% of patients of the Milan subset and in 10% of the whole sample. The overall mean survival was 60 months, with a 1-, 3- and 5-year survival probability of 74%, 40% and 29%, respectively. Lower survival was observed among patients with alcoholic etiology. Survival was higher among patients submitted to liver transplantation (P < 0.001), TACE (P < 0.001), or any kind of treatment (P < 0.001). However, no difference was found for surgical resection (P = 0.1) or sorafenib (P = 0.1). Conclusion. Patients with HCC were mainly older men diagnosed at an advanced stage. Treatment was associated with better overall survival, but few patients survived to be treated.

https://doi.org/10.5604/16652681.1231584 596 downloads

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