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Abstract Introduction: Autoimmune hepatitis (AIH) has a spectrum of symptoms ranging from asymptomatic disease to acute severe hepatitis, chronic hepatitis, and decompensated cirrhosis. The acute presentation is not rare and could represent genuine acute AIH (GAAIH) or acute exacerbation of chronic autoimmune hepatitis. We aimed to identify the prevalence, clinical features, and prognostic factors associated with GAAIH and compare these cases with acute exacerbation of chronic AIH. Methods: This cross-sectional observational study evaluated patients with acute AIH presentation, deﬁned as total bilirubin >5 times the upper limit of normality (xULN) and/or alanine aminotransferase >10 xULN, and no prior history of liver disease. Histology ﬁndings of acute disease deﬁned GAAIH. Bivariate analyses were performed to identify factors associated with the GAAIH, when compared with acute exacerbation of chronic AIH. Results: Seventy-two patients with acute presentation of AIH were included and six (8.3%) of them presented GAAIH. Comparative analysis between patients with GAAIH and patients with acute exacerbation of chronic AIH revealed that prothrombin activity (96% [74-100] vs. 61% [10-100]; p = 0.003) and albumin levels (3.9 ± 0.2 g/dL vs. 3.4 ± 0.5 g/dL; p < 0.001) were higher in patients with GAAIH. The International Autoimmune Hepatitis Group score was higher in patients with acute exacerbation of chronic AIH (18.5 [8-23] vs. 16.5 [15-17]; p = 0.010). Compared to 15.2% of acute exacerbation of chronic AIH, complete therapeutic response to treatment was achieved in 67.7% of cases with GAAIH (p = 0.018). Conclusions: GAAIH was rare (8.3%), and patients with this presentation exhibited more preserved liver function tests, suggesting that most cases presenting with loss of function are acute exacerbation of chronic AIH. Additionally, patients with GAAIH had a better complete therapeutic response, suggesting a more preserved liver function at presentation, and early diagnosis has a positive therapeutic implication.

Resumo Introdução: A hepatite autoimune (HAI) apresenta um espectro de sintomas que varia de doença assintomática a hepatite aguda grave, hepatite crónica e cirrose descompensada. A apresentação aguda não é rara e pode representar hepatite autoimune aguda genuína (HAIAG) ou exacerbação aguda de hepatite autoimune crónica (EAHAIC). O nosso objetivo foi identiﬁcar a prevalência, caraterísticas clínicas e fatores prognósticos associados à HAIAG, e comparar esses casos com EAHAIC. Métodos: Estudo observacional, transversal, incluindo doentes com apresentação aguda de HAI, deﬁnida como bilirrubina total > 5 vezes o limite superior da normalidade (xLSN) e/ou ALT > 10 xLSN, e sem história prévia de doença hepática. HAIAG foi deﬁnida pela presença de achados histológicos de doença aguda. Análises bivariadas foram realizadas para identiﬁcar fatores associados à HAIAG, quando comparado com o EAHAIC. Resultados: Foram incluídos setenta e dois doentes com apresentação agu-da de HAI, dos quais seis (8.3%) com HAIAG. A análise comparativa entre doentes com HAIAG e doentes com EAHAIC mostrou que a atividade de protrombina (96%(74-100) versus 61% (10-100; p=0.003) e os níveis de albumina (3,9 ± 0,2 g/dL vs. 3,4 ± 0,5 g/dL; p < 0,001) foram signiﬁcativamente mais elevados em pacientes com HAIAG. O score do Grupo Internacional de Hepatite Autoimune foi mais elevado em doentes com EAHAIC (18.5 (8-23) versus 16.5 (15-17); p=0.010). A resposta terapêutica completa ao tratamento foi alcançada em 66.7% dos casos de HAIAG (vs. 15,2% na EAHAIC, p=0,018). Conclusões: A HAIAG é rara (8.3%), e os doentes com esta apresentação mostraram testes de função hepática mais preservados, sugerindo que a maioria dos casos com perda de função são EAHAIC. Além disso, os doentes com HAIAG tiveram maior taxa de resposta terapêutica completa, sugerindo que uma função hepática mais preservada na apresentação e o diagnóstico precoce tem uma implicação terapêutica positiva.

https://doi.org/10.1159/000531018

Association between self-perception of the neighborhood environment and sleep problems in older Brazilian adults: findings from ELSI-Brazil
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Sutil, Daiana Vieira

; Moreira, Bruno de Souza

; Canever, Jaquelini Betta

; Cândido, Letícia Martins

; Danielewicz, Ana Lúcia

; Lima-Costa, Maria Fernanda

; Avelar, Núbia Carelli Pereira de

Cadernos de Saúde Pública

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2024, Volume 40 N. 4 elocation e00141623

Abstract: Es Pt En | Text: Es Pt En | PDF: Es | PDF: Pt | PDF: En

Resumen: Este estudio tuvo como objetivo investigar las asociaciones entre las percepcion del vecindario y los problemas de sueño en ancianos brasileños. Se realizó un estudio transversal con 5.719 ancianos de la comunidad (≥ 60 años) del Estudio Longitudinal de Salud de los Ancianos Brasileños (ELSI-Brasil, 2019-2021). Los desenlaces fueron los siguientes: problemas de sueño autoinformados: mala calidad del sueño, somnolencia diurna, quejas de insomnio primario, dificultad para permanecer dormido y despertarse durante la madrugada. Las variables de exposición fueron las siguientes: preguntas sobre la percepción de los participantes sobre el entorno físico y social del vecindario. En el análisis de datos se utilizó la regresión logística. La basura, la suciedad o el césped alto en las calles y el deseo de cambiar el lugar donde viven se asociaron con mayores probabilidades de tener una mala calidad del sueño. La preocupación por las caídas debido a aceras en mal estado, la preocupación por las dificultades para utilizar los medios de transporte y la preocupación por las dificultades para cruzar la calle se asociaron con mayores probabilidades de sufrir todos los problemas de sueño. El ruido producido por los autobuses y automóviles se asoció con una mayor probabilidad de sufrir algunos problemas de sueño. La percepción del vecindario como un buen lugar para vivir se asoció con menores probabilidades de sufrir somnolencia diurna y quejas de insomnio primario. La confianza en la mayoría de la gente del vecindario y la percepción de que los niños y jóvenes tratan a los adultos con respeto se asociaron con menores probabilidades de sufrir somnolencia diurna, quejas de insomnio primario y despertarse durante la madrugada. Un buen lugar para que los niños jugaran y para que los adolescentes crecieran se asoció con menores probabilidades de sufrir somnolencia diurna. Estos resultados pueden ayudar a los gestores públicos a crear políticas de planificación urbana dirigidas a mejorar los entornos vecinales como forma de promover la salud.

Resumo: Este estudo teve como objetivo investigar associações entre percepções da vizinhança e problemas de sono em idosos brasileiros. Foi realizado um estudo transversal com 5.719 idosos da comunidade (≥ 60 anos) do Estudo Longitudinal da Saúde dos Idosos Brasileiros (ELSI-Brasil, 2019-2021). Os desfechos foram problemas de sono autorreferidos: má qualidade do sono, sonolência diurna, queixas de insônia primária, dificuldade em manter o sono e acordar na madrugada. As variáveis de exposição foram: questões sobre a percepção dos participantes sobre o ambiente físico e social da vizinhança. Regressão logística foi utilizada na análise dos dados. Lixo, sujeira ou grama alta nas ruas e o desejo de mudar de onde mora foram associados a maiores chances de má qualidade do sono. Preocupação em cair devido a calçadas em má condição, preocupação com dificuldades para usar os meios de transporte e preocupação com dificuldades para atravessar a rua foram associadas a maiores chances de todos os problemas de sono. O som/ruído dos ônibus e carros foi associado a maiores chances de alguns problemas de sono. A percepção da vizinhança como um bom lugar para morar foi associado a menores chances de sonolência diurna e queixas de insônia primária. A confiança na maioria das pessoas da vizinhança e a percepção de que crianças e jovens tratam os adultos com respeito foram associados a menores chances de sonolência diurna, queixas de insônia primária e acordar na madrugada. Um bom lugar para as crianças brincarem e para os adolescentes crescerem foi associado a menores chances de sonolência diurna. Esses resultados podem ajudar os gestores públicos na criação de políticas de planejamento urbano voltadas a melhorias nos ambientes da vizinhança como forma de promoção da saúde.

Abstract: This study aimed to investigate associations between neighborhood perception and sleep problems in older Brazilian adults. A cross-sectional study was conducted with 5,719 community-dwelling older adults (≥ 60 years) from the Brazilian Longitudinal Study of Aging (ELSI-Brazil, 2019-2021). The outcomes were self-reported sleep problems: poor sleep quality, daytime sleepiness, primary insomnia complaints, difficulty staying asleep, and waking up at dawn. The exposure variables were questions about the perception of participants about the physical and social environment of the neighborhood. Logistic regression was used in data analysis. Garbage, rubbish, or tall grass on the streets and the desire to move were associated with higher odds of poor sleep quality. Concern about falling due to damaged sidewalks, concern about having difficulties taking transportation, and concern about having difficulties crossing the street were associated with higher odds of all sleep problems. Sound/noise of buses and cars was associated with higher odds of some sleep problems. Perceiving the neighborhood as a good place to live was associated with lower odds of daytime sleepiness and primary insomnia complaints. Trusting most people in the neighborhood and perceiving that kids and younger people treat adults with respect were associated with lower odds of daytime sleepiness, primary insomnia complaints, and waking up at dawn. Being a good place for kids to play and raise teenagers was associated with lower odds of daytime sleepiness. These results can assist public administrators in creating urban planning policies aimed at improving neighborhood environments as a means of health promotion.

https://doi.org/10.1590/0102-311xen141623

Padrão temporal, distribuição espacial e fatores associados a incidência de HIV/AIDS entre jovens no Brasil
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Ribeiro, Leonardo Miranda

; Figueira, Joana Nágila Ribeiro

; Abreu, Aline Miranda de

; Araújo, Antônia Vitória Elayne Carneiro

; Brito, Poliana Veras de

; Sousa, George Jó Bezerra

; Maranhão, Thatiana Araújo

; Pereira, Maria Lúcia Duarte

Revista Panamericana de Salud Pública

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2024, Volume 48 elocation e52

Abstract: Es En Pt | Text: Es En Pt | PDF: Es | PDF: En | PDF: Pt

RESUMEN Objetivo. Describir el patrón temporal y espacial, y determinar los factores asociados a la incidencia de infección por el VIH/sida en jóvenes en Brasil. Método. Estudio ecológico en jóvenes brasileños de 15 a 24 años con diagnóstico de infección por el VIH/sida en el período 2001-2021. Para el análisis temporal se utilizó el método de regresión de puntos de inflexión (joinpoint). Los conglomerados espaciales se detectaron con métodos Bayesianos y de autocorrelación espacial, Gi* de Getis-Ord y escaneo. Se utilizaron cuatro modelos de regresión espacial y no espacial para detectar los factores asociados al resultado. En todos los análisis estadísticos se estableció un valor de p < 0,05 como umbral de significación. Resultados. En Brasil, la incidencia media fue de 12,29 por 100 000 habitantes, con un aumento del 7,3% anual en el período 2007-2014 y una reducción posterior del 3,4% en el período 2014-2021. Se observó un patrón alto/alto y la presencia de puntos calientes, principalmente en municipios del Sur, Sudeste, Centro-Oeste y Norte. El principal conglomerado se localizó en 572 municipios de Rio Grande do Sul y Santa Catarina, y los riesgos relativos más altos se observaron en Manaus (Amazonas) y Rondonópolis (Mato Grosso). La tasa de analfabetismo (β = -0,08), el índice de Gini (β = -3,74) y la cobertura de la estrategia de salud familiar (β = -0,70) mostraron una asociación negativa con el resultado. En cambio, el índice de Firjan de desarrollo municipal (β = 2,37), el índice de vulnerabilidad social (β = 6,30), el porcentaje de personas que reciben ayuda del programa de bienestar social Bolsa Família (β = 0,04) y los ingresos per cápita (β = 0,008) mostraron una asociación positiva. Conclusión. Hubo una tendencia al aumento de la incidencia de infección por el VIH/sida hasta el 2014, con una reducción posterior hasta el 2021. Los conglomerados de tasas elevadas se concentraron especialmente en los municipios de las regiones Norte, Sur, Sudeste y Centro-Oeste. Los indicadores de vulnerabilidad socioeconómica tienen una influencia positiva o negativa en el resultado, según el territorio investigado.

ABSTRACT Objective. To describe temporal and spatial patterns and identify the factors associated with the incidence of HIV/AIDS among young people in Brazil. Method. Ecological study of young Brazilians aged 15-24 years with reported HIV/AIDS, from 2001 to 2021. The Joinpoint method was used for the temporal analysis. Spatial clusters were detected using Bayesian methods, spatial autocorrelation, Getis-Ord Gi*, and scan techniques. Four non-spatial and spatial regression models were used to identify factors associated with the result. All statistical analyses considered p < 0.05. Results. In Brazil, the average incidence was 12.29 per 100 000 inhabitants, with an annual increase of 7.3% in the period 2007-2014 and a subsequent 3.4% decrease in 2014-2021. A high-high pattern and hotspots were observed, mainly in municipalities in the South, Southeast, Central-West, and North regions. The primary cluster was located in 572 municipalities in Rio Grande do Sul and Santa Catarina, with the highest relative risks in Manaus (Amazonas) and Rondonópolis (Mato Grosso). The illiteracy rate (β = -0.08), GINI Index (β = -3.74) and Family Health Strategy coverage (β = -0.70) were negatively associated with the result. In contrast, the Firjan Municipal Development Index (β = 2.37), Social Vulnerability Index (β = 6.30), percentage of Bolsa Família recipients (β = 0.04), and per capita income (β = 0.008) showed a positive association. Conclusion. There was an upward trend in the incidence of HIV/AIDS until 2014, followed by a decline until 2021. High-rate clusters were concentrated in municipalities in the North, South, Southeast and Central-West regions in particular. Indicators of socioeconomic vulnerability had positive or negative effects on the result, depending on the territory investigated.

RESUMO Objetivo. Descrever o padrão temporal e espacial e identificar os fatores associados a incidência de HIV/AIDS entre jovens no Brasil. Método. Estudo ecológico que incluiu jovens brasileiros de 15 a 24 anos notificados com HIV/AIDS de 2001 a 2021. Utilizou-se o método joinpoint para a análise temporal. Aglomerados espaciais foram detectados pelos métodos Bayesiano, autocorrelação espacial, Getis-Ord Gi* e Varredura Scan. Quatro modelos de regressão não espacial e espacial foram usados para identificar fatores associados ao desfecho. Todas as análises estatísticas consideraram p < 0,05. Resultados. No Brasil, a incidência média foi de 12,29 por 100 000 habitantes, com aumento de 7,3% ao ano no período 2007-2014 e posterior decréscimo de 3,4% em 2014-2021. Observou-se padrão Alto/Alto e hotspots, principalmente em municípios do Sul, Sudeste, Centro-Oeste e Norte. O cluster primário localizou-se em 572 municípios do Rio Grande do Sul e Santa Catarina e os maiores riscos relativos em Manaus (Amazonas) e Rondonópolis (Mato Grosso). A taxa de analfabetismo (β = -0,08), Índice de GINI (β = -3,74) e Cobertura da Estratégia de Saúde da Família (β = -0,70) apresentaram relação negativa com o desfecho. Em contrapartida, o Índice Firjan de Desenvolvimento Municipal (β = 2,37), o Índice de Vulnerabilidade Social (β = 6,30), o percentual de pessoas que recebem o Bolsa Família (β = 0,04) e renda per capita (β = 0,008) apresentaram associação positiva. Conclusão. Houve tendência de aumento da incidência de HIV/AIDS até 2014 com posterior declínio até 2021. Aglomerados de altas taxas concentraram-se, especialmente, em municípios das regiões Norte, Sul, Sudeste e Centro-Oeste. Indicadores de vulnerabilidade socioeconômica influenciam o desfecho positivamente ou negativamente, dependendo do território investigado.

https://doi.org/10.26633/rpsp.2024.52

Diretrizes Brasileiras de Medidas da Pressão Arterial Dentro e Fora do Consultório – 2023 202 20 2
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Feitosa, Audes Diogenes de Magalhães

; Barroso, Weimar Kunz Sebba

; Mion Junior, Decio

; Nobre, Fernando

; Mota-Gomes, Marco Antonio

; Jardim, Paulo Cesar Brandão Veiga

; Amodeo, Celso

; Oliveira, Adriana Camargo

; Alessi, Alexandre

; Sousa, Ana Luiza Lima

; Brandão, Andréa Araujo

; Pio-Abreu, Andrea

; Sposito, Andrei C.

; Pierin, Angela Maria Geraldo

; Paiva, Annelise Machado Gomes de

; Spinelli, Antonio Carlos de Souza

; Machado, Carlos Alberto

; Poli-de-Figueiredo, Carlos Eduardo

; Rodrigues, Cibele Isaac Saad

; Forjaz, Claudia Lucia de Moraes

; Sampaio, Diogo Pereira Santos

; Barbosa, Eduardo Costa Duarte

; Freitas, Elizabete Viana de

; Cestario, Elizabeth do Espirito Santo

; Muxfeldt, Elizabeth Silaid

; Lima Júnior, Emilton

; Campana, Erika Maria Gonçalves

; Feitosa, Fabiana Gomes Aragão Magalhães

; Consolim-Colombo, Fernanda Marciano

; Almeida, Fernando Antônio de

; Silva, Giovanio Vieira da

; Moreno Júnior, Heitor

; Finimundi, Helius Carlos

; Guimarães, Isabel Cristina Britto

; Gemelli, João Roberto

; Barreto-Filho, José Augusto Soares

; Vilela-Martin, José Fernando

; Ribeiro, José Marcio

; Yugar-Toledo, Juan Carlos

; Magalhães, Lucélia Batista Neves Cunha

; Drager, Luciano F.

; Bortolotto, Luiz Aparecido

; Alves, Marco Antonio de Melo

; Malachias, Marcus Vinícius Bolívar

; Neves, Mario Fritsch Toros

; Santos, Mayara Cedrim

; Dinamarco, Nelson

; Moreira Filho, Osni

; Passarelli Júnior, Oswaldo

; Vitorino, Priscila Valverde de Oliveira

; Miranda, Roberto Dischinger

; Bezerra, Rodrigo

; Pedrosa, Rodrigo Pinto

; Paula, Rogerio Baumgratz de

; Okawa, Rogério Toshiro Passos

; Póvoa, Rui Manuel dos Santos

; Fuchs, Sandra C.

; Lima, Sandro Gonçalves de

; Inuzuka, Sayuri

; Ferreira-Filho, Sebastião Rodrigues

; Fillho, Silvio Hock de Paffer

; Jardim, Thiago de Souza Veiga

; Guimarães Neto, Vanildo da Silva

; Koch, Vera Hermina Kalika

; Gusmão, Waléria Dantas Pereira

; Oigman, Wille

; Nadruz Junior, Wilson

Arquivos Brasileiros de Cardiologia

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2024, Volume 121 N. 4 elocation e20240113

Abstract: Pt | Text: Pt | PDF: Pt

https://doi.org/10.36660/abc.20240113

Vulnerabilidade em saúde: evidências de validade de um banco de itens saúde
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Florêncio, Raquel Sampaio

; Cestari, Virna Ribeiro Feitosa

; Azevedo, Samir Gabriel Vasconcelos

; Borges, José Wicto Pereira

; Santiago, Jênifa Cavalcante dos Santos

; Pessoa, Vera Lúcia Mendes de Paula

; Moreira, Thereza Maria Magalhães

Acta Paulista de Enfermagem

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2024, Volume 37 elocation eAPE006022

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

Resumo Objetivo Analisar as evidências de validade de conteúdo e processo de resposta de um banco de itens sobre vulnerabilidade em saúde. Métodos Estudo psicométrico, subsidiado pelo polo teórico de Pasquali. Foram selecionados 62 especialistas com características sociodemográficas e acadêmicas distintas. Desses, 15 responderam ao questionário de validade de conteúdo. Após os ajustes, o banco passou para fase de validade de processo de resposta e foi avaliado por 12 usuários dos serviços de saúde. Utilizou-se coeficiente de validade de conteúdo para avaliação dos itens e do banco, cuja confiabilidade foi verificada pelo teste binomial, considerando percentual de 80% e p-valor >0,05. Resultados O banco apresentou boa evidência de validade de conteúdo pelos especialistas, cujos coeficientes foram 0,87 para o elemento sujeito, 0,86 para o elemento social e 0,865 para o geral. O público-alvo realizou sugestões na fase de validade de processo de resposta para melhor compreensão dos itens (coeficiente total: 0,89), sendo considerado, claro, preciso e compreensível. Conclusão A versão final do banco de itens possui 535 itens, sendo 238 para o sujeito e 297 para o social. Apresenta indícios de evidência de validade de conteúdo e processo de resposta e está apto para testagem de validade de estrutura interna. saúde psicométrico Pasquali 6 distintas Desses 1 ajustes Utilizouse Utilizou se binomial 80 pvalor p valor 005 0 05 >0,05 087 87 0,8 086 86 0865 865 geral públicoalvo público alvo total 0,89, 089 0,89 , 89 0,89) considerado claro compreensível 53 23 29 interna 8 00 >0,0 08 0, 5 2 >0, >0 >

Abstract Objective To analyze the evidence of content validity and response process of a health vulnerability item bank. Methods Psychometric study with support of Pasquali’s theoretical pole in which 62 specialists with different sociodemographic and academic characteristics were selected and 15 of them responded to the content validity questionnaire. After adjustments, the bank moved to the response process validity phase and was evaluated by 12 health service users. A content validity coefficient was used to evaluate the items and the bank, which had the reliability assessed by the binomial test, considering a percentage of 80% and p-value >0.05. Results The bank presented good evidence of content validity by experts. The coefficients were 0.87 for the subject element, 0.86 for the social element and 0.865 for the general element. The target audience made suggestions in the response process validity phase to better understand the items (total coefficient: 0.89), which were considered clear, accurate and understandable. Conclusion The final version of the item bank has 535 items, 238 for the subject and 297 for the social element. It presents evidence of validity of content and response process and is suitable for testing the validity of internal structure. Pasqualis Pasquali s 6 1 questionnaire adjustments users test 80 pvalue p value 005 0 05 >0.05 experts 087 87 0.8 086 86 0865 865 total 0.89, 089 0.89 , 89 0.89) clear understandable 53 23 29 structure 8 00 >0.0 08 0. 5 2 >0. >0 >

Resumen Objetivo Analizar las evidencias de validez de contenido y proceso de respuesta de un banco de ítems sobre vulnerabilidad en salud. Métodos Estudio psicométrico, fundamentado por el polo teórico de Pasquali. Se seleccionaron 62 especialistas con características sociodemográficas y académicas diferentes. Entre ellos, 15 respondieron al cuestionario de validez de contenido. Después de las adaptaciones, el banco pasó a la fase de validez del proceso de respuesta y fue evaluado por 12 usuarios de los servicios de salud. Se utilizó el coeficiente de validez de contenido para evaluar los ítems y el banco, cuya fiabilidad ser verificó mediante la prueba binominal, que consideró un porcentaje de 80 y p-valor >0,05. Resultados El banco presentó buena evidencia de validez de contenido por los especialistas, cuyos coeficientes fueron 0,87 en el elemento sujeto, 0,86 en el elemento social y 0,865 en el general. El público destinatario realizó sugerencias en la fase de validez del proceso de respuesta para una mejor comprensión de los ítems (coeficiente total: 0,89) y fue considerado claro, preciso y comprensible. Conclusión La versión final del banco de ítems contiene 535 ítems, de los cuales 238 son para el sujeto y 297 para el social. Presenta indicios de evidencia de validez de contenido y proceso de respuesta y está apto para una prueba de validez de estructura interna. salud psicométrico Pasquali 6 diferentes ellos 1 adaptaciones binominal 8 pvalor p valor 005 0 05 >0,05 087 87 0,8 086 86 0865 865 general total 0,89 089 89 claro comprensible 53 23 29 interna 00 >0,0 08 0, 5 2 >0, >0 >

https://doi.org/10.37689/acta-ape/2024ao0000602

Recommendations on cutaneous and hematological manifestations of Sjögren’s disease by the Brazilian Society of Rheumatology Sjögrens Sjögren s
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Pugliesi, Alisson

; Egypto, Danielle Christinne Soares do

; Duffles, Guilherme

; Cantali, Diego Ustárroz

; Pasoto, Sandra Gofinet

; Oliveira, Fabiola Reis

; Valim, Valeria

; Lopes, Maria Lucia Lemos

; Miyamoto, Samira Tatiyama

; Fernandes, Marilena Leal Mesquita Silvestre

; Fialho, Sonia Cristina de Magalhães Souza

; Pinheiro, Aysa César

; Santos, Laura Caldas dos

; Appenzeller, Simone

; Ribeiro, Sandra Lucia Euzébio

; Libório-Kimura, Tatiana Nayara

; Santos, Maria Carmen Lopes Ferreira Silva

; Gennari, Juliana D´Agostino

; Pernanbuco, Roberta

; Capobiano, Karina Gatz

; Civile, Vinicius Tassoni

; Pinto, Ana Carolina Pereira Nunes

; Rocha-Filho, César Ramos

; Rocha, Aline Pereira da

; Trevisani, Virginia Fernandes Moça

Advances in Rheumatology

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2024, Volume 64 elocation 51

Abstract: En | Text: En | PDF: En

Abstract Sjogren’s disease (SjD) is an autoimmune disease that is characterized not only by the sicca symptoms it causes but also by its systemic nature, which is capable of several and not yet fully understood extraglandular manifestations. To gain a clearer understanding of these manifestations as well as a better practical approach, a panel of experts from the Brazilian Society of Rheumatology conducted a systematic review and meta-analysis on the identification of epidemiologic and clinical features of the extraglandular manifestations present in ESSDAI (EULAR Sjogren´s syndrome disease activity index), followed by a voting panel with recommendations for clinical practice. This publication is complementary to others already published and covers cutaneous and hematological manifestations, with prevalence data generated by a meta-analysis of 13 clinical or laboratory manifestations and 6 clinical management recommendations. Sjogrens Sjogren s SjD (SjD nature approach metaanalysis meta analysis EULAR index, index , index) practice 1

https://doi.org/10.1186/s42358-024-00391-x

Serum osteoprotegerin and its gene polymorphisms in patients with Takayasu’s arteritis: a bicentric cross-sectional study Takayasus Takayasu s arteritis crosssectional cross sectional
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Duran, Camila da Silva Cendon

; Caparbo, Valéria de Falco

; Santiago, Mittermayer Barreto

; Hounkpe, Bidossessi Wilfried

; Pedreira, Ana Luisa Souza

; Lima, Isabella Vargas de Souza

; Giardini, Henrique Ayres Mayrink

; Bonoldi, Virgínia Lucia Nazario

; Domiciano, Diogo Souza

; Shinjo, Samuel Katsuyuki

; Pereira, Rosa Maria R

Advances in Rheumatology

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2024, Volume 64 elocation 43

Abstract: En | Text: En | PDF: En

Abstract Introduction Takayasu’s arteritis (TAK) patients are at an elevated risk of metabolic syndrome and cardiovascular diseases (CVD). Currently, there are no well-validated biomarkers to assess this risk in this population. Previous research in different cohorts has linked serum levels of osteoprotegerin (OPG) and its polymorphisms to accelerated atherosclerosis and a marker of poor prognosis in CVD. Thus, we assessed this protein as a potential biomarker of CVD in TAK patients. Objectives To evaluate the serum levels of OPG and its SNPs (single nucleotide polymorphisms) in TAK patients and healthy controls, and to associate these parameters with clinical data. Methods This bicentric cross-sectional study included TAK patients who were compared with healthy individuals (control group). The serum levels of OPG and the frequency of OPG SNPs [1181G > C (rs2073618), 245 A > C (rs3134069), 163T > C (rs3102735), and 209 C > T (rs3134070)] were compared between the both groups and associated with clinical data. Results In total, 101 TAK patients and 93 controls were included in the study. The serum levels of OPG (3.8 ± 1.9 vs. 4.3 ± 1.8pmol/L, respectively; P = 0.059), and its four polymorphisms were comparable between both groups. In an additional analysis of only TAK patients, serum OPG levels and its four genes were not associated with any CVD parameters, except for higher OPG levels among patients without dyslipidemia. Conclusion No significant differences were observed in serum OPG levels or in the genotype frequencies of OPG SNPs between the patient and control groups. Similarly, no correlation was found between laboratory parameters and clinical data on CVD risk in TAK patients. Takayasus Takayasu s (TAK . (CVD) Currently wellvalidated well validated population (OPG Thus single crosssectional cross sectional group. group group) 1181G G rs2073618, rs2073618 rs , (rs2073618) 24 rs3134069, rs3134069 (rs3134069) rs3102735, rs3102735 (rs3102735) 20 rs3134070 (rs3134070) total 10 9 3.8 38 3 8 (3. 19 1 1. vs 43 4 4. 18pmolL pmolL 8pmol L pmol 1.8pmol/L respectively 0.059, 0059 0.059 0 059 0.059) dyslipidemia Similarly (CVD rs207361 (rs2073618 2 rs313406 (rs3134069 rs310273 (rs3102735 rs313407 (rs3134070 3. (3 005 0.05 05 rs20736 (rs207361 rs31340 (rs313406 rs31027 (rs310273 (rs313407 ( 00 0.0 rs2073 (rs20736 rs3134 (rs31340 rs3102 (rs31027 0. rs207 (rs2073 rs313 (rs3134 rs310 (rs3102 rs20 (rs207 rs31 (rs313 (rs310 rs2 (rs20 rs3 (rs31 (rs2 (rs3 (rs

https://doi.org/10.1186/s42358-024-00384-w

Feelings expressed by professionals caring for children and teenagers victims of sexual violence
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Conceição, Marimeire Morais da

; Camargo, Climene Laura de

; Whitaker, Maria Carolina Ortiz

; Silva, Camila Tahis dos Santos

; Gomes, Nildete Pereira

; Rusmando, Lúcia Cristina Santos

Revista Latino-Americana de Enfermagem

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2024, Volume 32 elocation e4251

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

Resumo Objetivo: descrever sentimentos expressos por profissionais de saúde no atendimento a vítimas infantojuvenis da violência sexual na perspectiva teórica do Interacionismo Simbólico. Método: pesquisa qualitativa realizada com 30 mulheres profissionais da saúde. Foi aplicado instrumento composto de questões fechadas para dados sociodemográficos e roteiro com perguntas abertas para a entrevista. Os dados foram organizados e analisados no software Nvivo versão 12, de acordo com a proposta de Bardin, sob a ótica do Interacionismo Simbólico na obra de Charles Morris. O projeto foi aprovado por Comitê de Ética em Pesquisa. Resultados: emergiram cinco categorias temáticas que revelaram sentimentos de empatia, medo, indignação, sofrimento e consternação. Tais sentimentos permaneceram na memória das entrevistadas, tornando o atendimento a vítimas infantojuvenis da violência sexual uma experiência tocante, difícil e que marca profundamente a vida do profissional de saúde. Conclusão: há necessidade de adotar estratégias de apoio à saúde mental de profissionais que atuam em serviços que prestam atendimento geral a crianças e adolescentes, considerando que existe a possibilidade de estes atenderem a vítimas infantojuvenis da violência sexual em respeito às políticas públicas preexistentes. Objetivo Método 3 entrevista 12 Bardin Morris Pesquisa Resultados empatia medo indignação consternação entrevistadas tocante Conclusão adolescentes preexistentes 1

Abstract Objective: to describe the feelings expressed by health professionals when caring for child and adolescent victims of sexual violence from the theoretical perspective of Symbolic Interactionism. Method: qualitative research carried out with 30 female health professionals. An instrument was used consisting of closed questions for sociodemographic data and a script with open questions for interviews. The data was organized and analyzed using Nvivo software version 12, according to Bardin’s proposal, from the perspective of Symbolic Interactionism in the work of Charles Morris. The project was approved by the Research Ethics Committee. Results: five thematic categories emerged, revealing feelings of empathy, fear, indignation, suffering, and consternation. These feelings remained in the interviewees’ memories, making caring for child and adolescent victims of sexual violence a moving and difficult experience that deeply marks the life of the health professional. Conclusion: there is a need to adopt strategies to support the mental health of professionals who work in services that provide general care to children and adolescents, considering that there is a possibility that they will provide care to child and adolescent victims of sexual violence in compliance with pre-existing public policies. Objective Method 3 interviews 12 Bardins Bardin s proposal Morris Committee Results emerged empathy fear indignation suffering consternation interviewees memories professional Conclusion adolescents preexisting pre existing policies 1

Resumen Objetivo: describir los sentimientos expresados por los profesionales de la salud en la atención a víctimas infantojuveniles de violencia sexual desde la perspectiva teórica del Interaccionismo Simbólico. Métodos: investigación cualitativa realizada con 30 profesionales de salud. Se utilizó un instrumento compuesto por preguntas cerradas para los datos sociodemográficos y un guión con preguntas abiertas para la entrevista. Los datos fueron organizados y analizados utilizando el software Nvivo versión 12, de acuerdo con la propuesta de Bardin, desde la perspectiva del Interaccionismo Simbólico en la obra de Charles Morris. El proyecto fue aprobado por el Comité de Ética de la Investigación. Resultados: surgieron cinco categorías temáticas que revelaron sentimientos de empatía, miedo, indignación, sufrimiento y consternación. Estos sentimientos permanecieron en la memoria de los entrevistados, convirtiendo la atención a infantojuveniles víctimas de violencia sexual en una experiencia conmovedora y difícil que marca profundamente la vida del profesional de salud. Conclusión: es necesario adoptar estrategias de apoyo a la salud mental de los profesionales que actúan en servicios de atención general a infantojuveniles, considerando que existe la posibilidad de que atiendan a infantojuveniles víctimas de violencia sexual en cumplimiento de políticas públicas preexistentes. Objetivo Métodos 3 entrevista 12 Bardin Morris Investigación Resultados empatía miedo indignación consternación entrevistados Conclusión preexistentes 1

https://doi.org/10.1590/1518-8345.7157.4251

Association between self-perception of the neighborhood environment and sleep problems in older Brazilian adults: findings from ELSI-Brazil selfperception self perception adults ELSIBrazil ELSI Brazil
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Sutil, Daiana Vieira

; Moreira, Bruno de Souza

; Canever, Jaquelini Betta

; Cândido, Letícia Martins

; Danielewicz, Ana Lúcia

; Lima-Costa, Maria Fernanda

; Avelar, Núbia Carelli Pereira de

Cadernos de Saúde Pública

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2024, Volume 40 N. 4 elocation e00141623

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

https://doi.org/10.1590/0102-311xen141623

10.

Temporal Pattern and Spatial Distribution of Tuberculosis Prevalence Associated with Multimorbidity in Brazil
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Cabral, Bruno Victor Barros

; Sousa, George Jó Bezerra

; Cordeiro, Luana Ibiapina

; Maranhão, Thatiana Araújo

; Pereira, Maria Lúcia Duarte

Revista da Sociedade Brasileira de Medicina Tropical

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2024, Volume 57 elocation e00408-2024

Abstract: En | Text: En | PDF: En

ABSTRACT Background: Four main chronic conditions may be involved in the tuberculosis pathogenic process and/or clinical evolution: HIV/AIDS, diabetes mellitus, mental illness, and Chronic Obstructive Pulmonary Disease. This study aimed to determine the spatiotemporal pattern of tuberculosis (TB) associated with multimorbidity in Brazil. Methods: Ecological study use data from the Notifiable Diseases Information System (SINAN), collected from the electronic portal of the Department of Informatics of the SUS (DATASUS). These data included TB cases that were reported between 2007 and 2021 and were associated with two or more chronic clinical health conditions (multimorbidity). Results: A total of 7,795 cases of TB associated with multimorbidity were recorded, with an average growth trend of 4.6% per year (95% Confidence Interval (CI): 3.3-5.9; p<0.001) and higher growth in the first temporal segment (2007 to 2011) (8.9%; 95%CI: 4.2-13.9; p=0.002). The spatial analysis, after Bayesian smoothing, highlighted the main municipalities states of the study, namely: São Paulo (19.8%; n = 297), Porto Alegre (23.6%; n = 354), and Rio de Janeiro (44.8%; n = 672). The proportion of extremely poor (β=-0.002), the bolsa família program (β=0.002), the average per-person income (β=0.001), and the percentage of the population living in households with a density of more than 2 people per bedroom (β=0.001) were related to chronic health conditions. Conclusions: These findings will stimulate public action to manage this situation. However, as this is still a recent topic in the literature, we encourage the development of studies on the synergistic characteristics of TB and other clinical conditions. Background andor evolution HIVAIDS HIV AIDS HIV/AIDS mellitus illness Disease (TB Brazil Methods SINAN, SINAN , (SINAN) DATASUS. DATASUS . (DATASUS) 200 202 multimorbidity. (multimorbidity) Results 7795 7 795 7,79 recorded 46 4 6 4.6 95% 95 (95 CI (CI) 3.35.9 3359 3.3 5.9 3 5 9 3.3-5.9 p<0.001 p0001 p 0 001 (200 2011 8.9% 89 8 (8.9% 95%CI 95CI 4.213.9 42139 4.2 13.9 13 4.2-13.9 p=0.002. p0002 p=0.002 002 p=0.002) analysis smoothing namely 19.8% 198 19 (19.8% 297, 297 297) 23.6% 236 23 (23.6% 354, 354 354) 44.8% 448 44 (44.8% 672. 672 672) β=0.002, β0002 β β= 0.002 (β=-0.002) β=0.002 (β=0.002) perperson person β=0.001, β0001 β=0.001 (β=0.001 Conclusions situation However literature (SINAN (DATASUS 20 (multimorbidity 779 79 7,7 4. (9 (CI 35 3.35. 335 33 3. 59 5. 3.3-5. p<0.00 p000 00 (20 201 8.9 (8.9 213 4.213. 4213 42 139 13. 1 4.2-13. p=0.00 19.8 (19.8 29 23.6 (23.6 44.8 (44.8 67 β000 0002 0.00 (β=-0.002 β=0.00 (β=0.002 (β=0.00 77 7, ( 3.35 3.3-5 p<0.0 p00 (2 8. (8. 21 4.213 421 4.2-13 p=0.0 19. (19. 23. (23. 44. (44. β00 000 0.0 (β=-0.00 β=0.0 (β=0.0 3.3- p<0. p0 (8 4.21 4.2-1 p=0. (19 (23 (44 β0 0. (β=-0.0 β=0. (β=0. p<0 4.2- p=0 (1 (4 (β=-0. β=0 (β=0 p< p= (β=-0 (β= (β=- (β

https://doi.org/10.1590/0037-8682-0625-2023

11.

To be or not to B27 positive: implications for the phenotypes of axial spondyloarthritis outcomes. Data from a large multiracial cohort from the Brazilian Registry of Spondyloarthritis B B2 positive outcomes
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Resende, Gustavo Gomes

; Saad, Carla Goncalves Schahin

; Marques, Claudia Diniz Lopes

; Ribeiro, Sandra Lúcia Euzébio

; Gavi, Maria Bernadete Renoldi de Oliveira

; Yazbek, Michel Alexandre

; Marinho, Adriana de Oliveira

; Menin, Rita de Cássia

; Ochtrop, Manuella Lima Gomes

; Soares, Andressa Miozzo

; Cavalcanti, Nara Gualberto

; Carneiro, Jamille Nascimento

; Werner de Castro, Glaucio Ricardo

; Fernandes, José Mauro Carneiro

; Souza, Elziane da Cruz Ribeiro E

; Alvarenga, Corina Quental de Menezes

; Vieira, Rejane Maria Rodrigues de Abreu

; Machado, Natalia Pereira

; Ximenes, Antônio Carlos

; Gazzeta, Morgana Ohira

; Albuquerque, Cleandro Pires de

; Skare, Thelma Larocca

; Keiserman, Mauro Waldemar

; Kohem, Charles Lubianca

; Benacon, Gabriel Sarkis

; Rocha, Vítor Florêncio Santos

; Lage, Ricardo da Cruz

; Malheiro, Olivio Brito

; Golebiovski, Rywka Tenenbaum Medeiros

; Oliveira, Thauana Luiza

; Duque, Ruben Horst

; Londe, Ana Carolina

; Pinheiro, Marcelo de Medeiros

; Sampaio-Barros, Percival Degrava

Advances in Rheumatology

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2024, Volume 64 elocation 33

Abstract: En | Text: En | PDF: En

Abstract Background There is a remarkable variability in the frequency of HLA-B27 positivity in patients with spondyloarthritis (SpA), which may be associated with different clinical presentations worldwide. However, there is a lack of data considering ethnicity and sex on the evaluation of the main clinical and prognostic outcomes in mixed-race populations. The aim of this study was to evaluate the frequency of HLA-B27 and its correlation with disease parameters in a large population of patients from the Brazilian Registry of Spondyloarthritis (RBE). Methods The RBE is a multicenter, observational, prospective cohort that enrolled patients with SpA from 46 centers representing all five geographic regions of Brazil. The inclusion criteria were as follow: (1) diagnosis of axSpA by an expert rheumatologist; (2) age ≥18 years; (3) classification according to ASAS axial. The following data were collected via a standardized protocol: demographic data, disease parameters and treatment historical. Results A total of 1096 patients were included, with 73.4% HLA-B27 positivity and a mean age of 44.4 (±13.2) years. Positive HLA-B27 was significantly associated with male sex, earlier age at disease onset and diagnosis, uveitis, and family history of SpA. Conversely, negative HLA-B27 was associated with psoriasis, higher peripheral involvement and disease activity, worse quality of life and mobility. Conclusions Our data showed that HLA-B27 positivity was associated with a classic axSpA pattern quite similar to that of Caucasian axSpA patients around the world. Furthermore, its absence was associated with peripheral manifestations and worse outcomes, suggesting a relevant phenotypic difference in a highly miscegenated population. HLAB27 HLAB HLA B27 B HLA-B2 SpA, , (SpA) worldwide However mixedrace mixed race populations RBE. . (RBE) multicenter observational 4 Brazil follow 1 (1 rheumatologist 2 (2 18 ≥1 years 3 (3 axial protocol historical 109 included 734 73 73.4 444 44 44. ±13.2 132 13 (±13.2 uveitis Conversely psoriasis activity mobility world Furthermore HLAB2 B2 HLA-B (SpA (RBE ( ≥ 10 7 73. ±13. (±13. ±13 (±13 ±1 (±1 ± (±

https://doi.org/10.1186/s42358-024-00372-0

12.

DATA COLLECTION VIA PHONE IN MULTICENTRIC RESEARCH ON NURSING CARE IN THE FACE OF COVID-19 COVID19 COVID 19 COVID-1 COVID1 1 COVID-
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Cechinel-Peiter, Caroline

; Engel, Franciely Daiana

; Mello, Ana Lúcia Schaefer Ferreira de

; Costa, Diovane Ghignatti da

; Costa, Maria Fernanda Baeta Neves Alonso da

; Lanzoni, Gabriela Marcellino de Melo

; Santos, Viviane Euzébia Pereira

; Bohomol, Elena

; Zanchetta, Margareth Santos

; Santos, José Luís Guedes dos

; Erdmann, Alacoque Lorenzini

Texto & Contexto - Enfermagem

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2024, Volume 33 elocation e20220261

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

RESUMO Objetivo: Relatar a coleta de dados via telefone realizada em pesquisa multicêntrica sobre avaliação do cuidado de enfermagem durante a pandemia da COVID-19. Método: Relato de experiência sobre o uso do telefone para coleta de dados quantitativos e qualitativos com participantes de dez Hospitais Universitários Brasileiros, de outubro de 2020 a dezembro de 2021. A experiência foi apresentada segundo etapas: 1) Operacionalização da coleta de dados via telefone; 2) Capacitação da equipe de entrevistadores; 3) Acompanhamento e ajustes da coleta de dados; e 4) Resultados do contato telefônico com o paciente. Resultados: O planejamento e a organização da coleta de dados envolveram a construção de manuais de orientação para guiar os coletadores, os quais passaram por validação quanto à clareza e concordância. Para acompanhamento e ajustes, realizou-se reunião semanal com os entrevistadores e pesquisadores responsáveis. Foram incluídos dados de 539 respondentes do instrumento Patient Measure of Safety, de 643 do instrumento Care Transitions Measure e de 56 entrevistas abertas. Conclusão: A utilização de manuais de orientação para coleta de dados via telefone, realização de treinamentos e reuniões de acompanhamento são estratégias que podem potencializar essa estratégia em pesquisas multicêntricas, quando da impossibilidade de coleta face-a-face. Objetivo COVID19. COVID19 COVID 19. 19 COVID-19 Método Brasileiros 202 2021 etapas 1 2 3 4 paciente coletadores concordância realizouse realizou se responsáveis 53 Safety 64 5 abertas Conclusão multicêntricas faceaface. faceaface face face. face-a-face COVID1 COVID-1 20 6 COVID-

ABSTRACT Objective: to report data collection via telephone carried out in multicenter research on nursing care assessment during the COVID-19 pandemic. Method: this is an experience report on using the telephone to collect quantitative and qualitative data with participants from ten Brazilian university hospitals from October 2020 to December 2021. The experience was presented in stages: 1) Operationalization of data collection via telephone; 2) Interviewing team training; 3) Monitoring and adjustments to data collection; and 4) Results of telephone contact with patients. Results: data collection planning and organization involved creating guidance manuals to guide the collectors, which were validated for clarity and agreement. For monitoring and adjustments, a weekly meeting was held with the interviewers in charge and researchers. Data from 539 respondents from the Patient Measure of Safety instrument, 643 from the Care Transitions Measure instrument and 56 from open interviews were included. Conclusion: using guidance manuals for data collection via telephone, training and follow-up meetings are strategies that can enhance this strategy in multicenter research when in-person data collection is impossible. Objective COVID19 COVID 19 COVID-1 pandemic Method 202 2021 stages 1 2 3 4 patients collectors agreement researchers 53 64 5 included Conclusion followup follow up inperson person impossible COVID1 COVID- 20 6

RESUMEN Objetivo: informar la recolección de datos vía telefónica realizada en una investigación multicéntrica sobre la evaluación de los cuidados de enfermería durante la pandemia de COVID-19. Método: informe de experiencia sobre el uso del teléfono para la recolección de datos cuantitativos y cualitativos con participantes de diez hospitales universitarios brasileños, de octubre de 2020 a diciembre de 2021. La experiencia fue presentada en etapas: 1) Operacionalización de la recolección de datos por teléfono; 2) Capacitación del equipo entrevistador; 3) Monitoreo y ajustes a la recolección de datos; y 4) Resultados del contacto telefónico con el paciente. Resultados: la planificación y organización de la recolección de datos implicó la creación de manuales de orientación para guiar a los recolectores, los cuales fueron validados por su claridad y acuerdo. Para el seguimiento y ajustes se realizó una reunión semanal con los entrevistadores e investigadores responsables. Se incluyeron datos de 539 encuestados del instrumento Patient Measure of Safety, 643 del instrumento Care Transitions Measure y 56 entrevistas abiertas. Conclusión: el uso de manuales de orientación para la recolección de datos vía telefónica, capacitación y reuniones de seguimiento son estrategias que pueden potenciar esta estrategia en investigaciones multicéntricas cuando la recolección de datos presencial es imposible. Objetivo COVID19. COVID19 COVID 19. 19 COVID-19 Método brasileños 202 2021 etapas 1 2 entrevistador 3 4 paciente recolectores acuerdo responsables 53 Safety 64 5 abiertas Conclusión imposible COVID1 COVID-1 20 6 COVID-

https://doi.org/10.1590/1980-265x-tce-2022-0261en

13.

Validating evidence for the knowledge, management and involvement of dentists in a dental approach to sickle-cell disease knowledge sicklecell sickle cell
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ANCILLOTTI, Lucia Helena da Silva Ferreira

; ABREU, Mauro Henrique Nogueira Guimarães de

; MARINHO, Angélica Maria Cupertino Lopes

; SANTOS, Marcia Pereira Alves dos

Brazilian Oral Research

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2024, Volume 38 elocation e026

Abstract: En | Text: En | PDF: En

Abstract This study validated the content of an instrument designed to assess the knowledge, involvement (attitudes) and management (practice) of dentists relative to sickle-cell disease (KAPD-SCD). The instrument consisted of five domains composed of a total of thirteen items: I. Dentist’s self-assessment relative to sickle-cell disease; II. Dentist’s knowledge of the repercussions of sickle-cell disease on the stomatognathic system; III. Dentist’s knowledge of the complications of sickle-cell disease in the stomatognathic system; IV. Dentist’s knowledge concerning the dental management of sickle-cell disease patients; and V. Dentist’s involvement in an approach to sickle-cell disease. Twelve experts assigned scores to each item of the instrument. The criteria were clarity, understanding and appropriateness, leaving open fields for comments. Descriptive and content analyses of the data were made. Each expert analyzed 39 assessment units. The percentages considered for agreement were high (>80%), medium (70%-80%), or low (<70%), and each item was maintained or revised according to the percentage observed. There was high consensus in 74% of the assessment units (the corresponding items were maintained), medium consensus in 24% of them (the corresponding items were revised), and disagreement in 2% of them, namely as regards the “appropriateness” of item 5 (“Are there oral complications in sickle-cell disease?”), which was revised. The final version of the instrument had 16 items for different applications such as in the clinical care program, teaching program, or research program, with different cut-off scores for each application. In conclusion, the level of agreement among experts showed evidence of the content validity of the instrument. attitudes (attitudes practice (practice sicklecell sickle cell KAPDSCD. KAPDSCD KAPD SCD . (KAPD-SCD) I Dentists Dentist s selfassessment self II system III IV patients V clarity appropriateness comments made 3 >80%, 80 >80% , (>80%) 70%80%, 7080 70% 80% 70 (70%-80%) <70%, <70% (<70%) observed 74 maintained, maintained) 24 revised, revised) 2 “appropriateness Are disease, disease?”) 1 program cutoff cut off application conclusion (KAPD-SCD 8 >80 (>80% 70%80% 708 7 (70%-80% <70 (<70% disease?” >8 (>80 70%80 (70%-80 <7 (<70 disease? > (>8 70%8 (70%-8 < (<7 (> (70%- (< ( (70% (70 (7

https://doi.org/10.1590/1807-3107bor-2024.vol38.0026

14.

Catálogo Taxonômico da Fauna do Brasil: Setting the baseline knowledge on the animal diversity in Brazil Brasil
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Boeger, Walter A.

; Valim, Michel P.

; Zaher, Hussam

; Rafael, José A.

; Forzza, Rafaela C.

; Percequillo, Alexandre R.

; Serejo, Cristiana S.

; Garraffoni, André R.S.

; Santos, Adalberto J.

; Slipinski, Adam

; Linzmeier, Adelita M.

; Calor, Adolfo R.

; Garda, Adrian A.

; Kury, Adriano B.

; Fernandes, Agatha C.S.

; Agudo-Padrón, Aisur I.

; Akama, Alberto

; Silva Neto, Alberto M. da

; Burbano, Alejandro L.

; Menezes, Aleksandra

; Pereira-Colavite, Alessandre

; Anichtchenko, Alexander

; Lees, Alexander C.

; Bezerra, Alexandra M.R.

; Domahovski, Alexandre C.

; Pimenta, Alexandre D.

; Aleixo, Alexandre L.P.

; Marceniuk, Alexandre P.

; Paula, Alexandre S. de

; Somavilla, Alexandre

; Specht, Alexandre

; Camargo, Alexssandro

; Newton, Alfred F.

; Silva, Aline A.S. da

; Santos, Aline B. dos

; Tassi, Aline D.

; Aragão, Allan C.

; Santos, Allan P.M.

; Migotto, Alvaro E.

; Mendes, Amanda C.

; Cunha, Amanda

; Chagas Júnior, Amazonas

; Sousa, Ana A.T. de

; Pavan, Ana C.

; Almeida, Ana C.S.

; Peronti, Ana L.B.G.

; Henriques-Oliveira, Ana L.

; Prudente, Ana L.

; Tourinho, Ana L.

; Pes, Ana M.O.

; Carmignotto, Ana P.

; Wengrat, Ana P.G. da Silva

; Dornellas, Ana P.S.

; Molin, Anamaria Dal

; Puker, Anderson

; Morandini, André C.

; Ferreira, André da S.

; Martins, André L.

; Esteves, André M.

; Fernandes, André S.

; Roza, André S.

; Köhler, Andreas

; Paladini, Andressa

; Andrade, Andrey J. de

; Pinto, Ângelo P.

; Salles, Anna C. de A.

; Gondim, Anne I.

; Amaral, Antonia C.Z.

; Rondón, Antonio A.A.

; Brescovit, Antonio

; Lofego, Antônio C.

; Marques, Antonio C.

; Macedo, Antonio

; Andriolo, Artur

; Henriques, Augusto L.

; Ferreira Júnior, Augusto L.

; Lima, Aurino F. de

; Barros, Ávyla R. de A.

; Brito, Ayrton do R.

; Romera, Bárbara L.V.

; Vasconcelos, Beatriz M.C. de

; Frable, Benjamin W.

; Santos, Bernardo F.

; Ferraz, Bernardo R.

; Rosa, Brunno B.

; Sampaio, Brunno H.L.

; Bellini, Bruno C.

; Clarkson, Bruno

; Oliveira, Bruno G. de

; Corrêa, Caio C.D.

; Martins, Caleb C.

; Castro-Guedes, Camila F. de

; Souto, Camilla

; Bicho, Carla de L.

; Cunha, Carlo M.

; Barboza, Carlos A. de M.

; Lucena, Carlos A.S. de

; Barreto, Carlos

; Santana, Carlos D.C.M. de

; Agne, Carlos E.Q.

; Mielke, Carlos G.C.

; Caetano, Carlos H.S.

; Flechtmann, Carlos H.W.

; Lamas, Carlos J.E.

; Rocha, Carlos

; Mascarenhas, Carolina S.

; Margaría, Cecilia B.

; Waichert, Cecilia

; Digiani, Celina

; Haddad, Célio F.B.

; Azevedo, Celso O.

; Benetti, Cesar J.

; Santos, Charles M.D. dos

; Bartlett, Charles R.

; Bonvicino, Cibele

; Ribeiro-Costa, Cibele S.

; Santos, Cinthya S.G.

; Justino, Cíntia E.L.

; Canedo, Clarissa

; Bonecker, Claudia C.

; Santos, Cláudia P.

; Carvalho, Claudio J.B. de

; Gonçalves, Clayton C.

; Galvão, Cleber

; Costa, Cleide

; Oliveira, Cléo D.C. de

; Schwertner, Cristiano F.

; Andrade, Cristiano L.

; Pereira, Cristiano M.

; Sampaio, Cristiano

; Dias, Cristina de O.

; Lucena, Daercio A. de A.

; Manfio, Daiara

; Amorim, Dalton de S.

; Queiroz, Dalva L. de

; Colpani, Daniara

; Abbate, Daniel

; Aquino, Daniel A.

; Burckhardt, Daniel

; Cavallari, Daniel C.

; Prado, Daniel de C. Schelesky

; Praciano, Daniel L.

; Basílio, Daniel S.

; Bená, Daniela de C.

; Toledo, Daniela G.P. de

; Takiya, Daniela M.

; Fernandes, Daniell R.R.

; Ament, Danilo C.

; Cordeiro, Danilo P.

; Silva, Darliane E.

; Pollock, Darren A.

; Muniz, David B.

; Gibson, David I.

; Nogueira, David S.

; Marques, Dayse W.A.

; Lucatelli, Débora

; Garcia, Deivys M.A.

; Baêta, Délio

; Ferreira, Denise N.M.

; Rueda-Ramírez, Diana

; Fachin, Diego A.

; Souza, Diego de S.

; Rodrigues, Diego F.

; Pádua, Diego G. de

; Barbosa, Diego N.

; Dolibaina, Diego R.

; Amaral, Diogo C.

; Chandler, Donald S.

; Maccagnan, Douglas H.B.

; Caron, Edilson

; Carvalho, Edrielly

; Adriano, Edson A.

; Abreu Júnior, Edson F. de

; Pereira, Edson H.L.

; Viegas, Eduarda F.G.

; Carneiro, Eduardo

; Colley, Eduardo

; Eizirik, Eduardo

; Santos, Eduardo F. dos

; Shimbori, Eduardo M.

; Suárez-Morales, Eduardo

; Arruda, Eliane P. de

; Chiquito, Elisandra A.

; Lima, Élison F.B.

; Castro, Elizeu B. de

; Orlandin, Elton

; Nascimento, Elynton A. do

; Razzolini, Emanuel

; Gama, Emanuel R.R.

; Araujo, Enilma M. de

; Nishiyama, Eric Y.

; Spiessberger, Erich L.

; Santos, Érika C.L. dos

; Contreras, Eugenia F.

; Galati, Eunice A.B.

; Oliveira Junior, Evaldo C. de

; Gallardo, Fabiana

; Hernandes, Fabio A.

; Lansac-Tôha, Fábio A.

; Pitombo, Fabio B.

; Dario, Fabio Di

; Santos, Fábio L. dos

; Mauro, Fabio

; Nascimento, Fabio O. do

; Olmos, Fabio

; Amaral, Fabio R.

; Schunck, Fabio

; Godoi, Fábio S. P. de

; Machado, Fabrizio M.

; Barbo, Fausto E.

; Agrain, Federico A.

; Ribeiro, Felipe B.

; Moreira, Felipe F.F.

; Barbosa, Felipe F.

; Silva, Fenanda S.

; Cavalcanti, Fernanda F.

; Straube, Fernando C.

; Carbayo, Fernando

; Carvalho Filho, Fernando

; Zanella, Fernando C.V.

; Jacinavicius, Fernando de C.

; Farache, Fernando H.A.

; Leivas, Fernando

; Dias, Fernando M.S.

; Mantellato, Fernando

; Vaz-de-Mello, Fernando Z.

; Gudin, Filipe M.

; Albuquerque, Flávio

; Molina, Flavio B.

; Passos, Flávio D.

; Shockley, Floyd W.

; Pinheiro, Francielly F.

; Mello, Francisco de A.G. de

; Nascimento, Francisco E. de L.

; Franco, Francisco L.

; Oliveira, Francisco L. de

; Melo, Francisco T. de V.

; Quijano, Freddy R.B.

; Salles, Frederico F.

; Biffi, Gabriel

; Queiroz, Gabriel C.

; Bizarro, Gabriel L.

; Hrycyna, Gabriela

; Leviski, Gabriela

; Powell, Gareth S.

; Santos, Geane B. dos

; Morse, Geoffrey E.

; Brown, George

; Mattox, George M.T.

; Zimbrão, Geraldo

; Carvalho, Gervásio S.

; Miranda, Gil F.G.

; Moraes, Gilberto J. de

; Lourido, Gilcélia M.

; Neves, Gilmar P.

; Moreira, Gilson R.P.

; Montingelli, Giovanna G.

; Maurício, Giovanni N.

; Marconato, Gláucia

; Lopez, Guilherme E.L.

; Silva, Guilherme L. da

; Muricy, Guilherme

; Brito, Guilherme R.R.

; Garbino, Guilherme S.T.

; Flores, Gustavo E.

; Graciolli, Gustavo

; Libardi, Gustavo S.

; Proctor, Heather C.

; Gil-Santana, Helcio R.

; Varella, Henrique R.

; Escalona, Hermes E.

; Schmitz, Hermes J.

; Rodrigues, Higor D.D.

; Galvão Filho, Hilton de C.

; Quintino, Hingrid Y.S.

; Pinto, Hudson A.

; Rainho, Hugo L.

; Miyahira, Igor C.

; Gonçalves, Igor de S.

; Martins, Inês X.

; Cardoso, Irene A.

; Oliveira, Ismael B. de

; Franz, Ismael

; Fernandes, Itanna O.

; Golfetti, Ivan F.

; S. Campos-Filho, Ivanklin

; Oliveira, Ivo de S.

; Delabie, Jacques H.C.

; Oliveira, Jader de

; Prando, Jadila S.

; Patton, James L.

; Bitencourt, Jamille de A.

; Silva, Janaina M.

; Santos, Jandir C.

; Arruda, Janine O.

; Valderrama, Jefferson S.

; Dalapicolla, Jeronymo

; Oliveira, Jéssica P.

; Hájek, Jiri

; Morselli, João P.

; Narita, João P.

; Martin, João P.I.

; Grazia, Jocélia

; McHugh, Joe

; Cherem, Jorge J.

; Farias Júnior, José A.S.

; Fernandes, Jose A.M.

; Pacheco, José F.

; Birindelli, José L.O.

; Rezende, José M.

; Avendaño, Jose M.

; Duarte, José M. Barbanti

; Ribeiro, José R. Inácio

; Mermudes, José R.M.

; Pujol-Luz, José R.

; Santos, Josenilson R. dos

; Câmara, Josenir T.

; Teixeira, Joyce A.

; Prado, Joyce R. do

; Botero, Juan P.

; Almeida, Julia C.

; Kohler, Julia

; Gonçalves, Julia P.

; Beneti, Julia S.

; Donahue, Julian P.

; Alvim, Juliana

; Almeida, Juliana C.

; Segadilha, Juliana L.

; Wingert, Juliana M.

; Barbosa, Julianna F.

; Ferrer, Juliano

; Santos, Juliano F. dos

; Kuabara, Kamila M.D.

; Nascimento, Karine B.

; Schoeninger, Karine

; Campião, Karla M.

; Soares, Karla

; Zilch, Kássia

; Barão, Kim R.

; Teixeira, Larissa

; Sousa, Laura D. do N.M. de

; Dumas, Leandro L.

; Vieira, Leandro M.

; Azevedo, Leonardo H.G.

; Carvalho, Leonardo S.

; Souza, Leonardo S. de

; Rocha, Leonardo S.G.

; Bernardi, Leopoldo F.O.

; Vieira, Letícia M.

; Johann, Liana

; Salvatierra, Lidianne

; Oliveira, Livia de M.

; Loureiro, Lourdes M.A. El-moor

; Barreto, Luana B.

; Barros, Luana M.

; Lecci, Lucas

; Camargos, Lucas M. de

; Lima, Lucas R.C.

; Almeida, Lucia M.

; Martins, Luciana R.

; Marinoni, Luciane

; Moura, Luciano de A.

; Lima, Luciano

; Naka, Luciano N.

; Miranda, Lucília S.

; Salik, Lucy M.

; Bezerra, Luis E.A.

; Silveira, Luis F.

; Campos, Luiz A.

; Castro, Luiz A.S. de

; Pinho, Luiz C.

; Silveira, Luiz F.L.

; Iniesta, Luiz F.M.

; Tencatt, Luiz F.C.

; Simone, Luiz R.L.

; Malabarba, Luiz R.

; Cruz, Luiza S. da

; Sekerka, Lukas

; Barros, Lurdiana D.

; Santos, Luziany Q.

; Skoracki, Maciej

; Correia, Maira A.

; Uchoa, Manoel A.

; Andrade, Manuella F.G.

; Hermes, Marcel G.

; Miranda, Marcel S.

; Araújo, Marcel S. de

; Monné, Marcela L.

; Labruna, Marcelo B.

; Santis, Marcelo D. de

; Duarte, Marcelo

; Knoff, Marcelo

; Nogueira, Marcelo

; Britto, Marcelo R. de

; Melo, Marcelo R.S. de

; Carvalho, Marcelo R. de

; Tavares, Marcelo T.

; Kitahara, Marcelo V.

; Justo, Marcia C.N.

; Botelho, Marcia J.C.

; Couri, Márcia S.

; Borges-Martins, Márcio

; Felix, Márcio

; Oliveira, Marcio L. de

; Bologna, Marco A.

; Gottschalk, Marco S.

; Tavares, Marcos D.S.

; Lhano, Marcos G.

; Bevilaqua, Marcus

; Santos, Marcus T.T.

; Domingues, Marcus V.

; Sallum, Maria A.M.

; Digiani, María C.

; Santarém, Maria C.A.

; Nascimento, Maria C. do

; Becerril, María de los A.M.

; Santos, Maria E.A. dos

; Passos, Maria I. da S. dos

; Felippe-Bauer, Maria L.

; Cherman, Mariana A.

; Terossi, Mariana

; Bartz, Marie L.C.

; Barbosa, Marina F. de C.

; Loeb, Marina V.

; Cohn-Haft, Mario

; Cupello, Mario

; Martins, Marlúcia B.

; Christofersen, Martin L.

; Bento, Matheus

; Rocha, Matheus dos S.

; Martins, Maurício L.

; Segura, Melissa O.

; Cardenas, Melissa Q.

; Duarte, Mércia E.

; Ivie, Michael A.

; Mincarone, Michael M.

; Borges, Michela

; Monné, Miguel A.

; Casagrande, Mirna M.

; Fernandez, Monica A.

; Piovesan, Mônica

; Menezes, Naércio A.

; Benaim, Natalia P.

; Reategui, Natália S.

; Pedro, Natan C.

; Pecly, Nathalia H.

; Ferreira Júnior, Nelson

; Silva Júnior, Nelson J. da

; Perioto, Nelson W.

; Hamada, Neusa

; Degallier, Nicolas

; Chao, Ning L.

; Ferla, Noeli J.

; Mielke, Olaf H.H.

; Evangelista, Olivia

; Shibatta, Oscar A.

; Oliveira, Otto M.P.

; Albornoz, Pablo C.L.

; Dellapé, Pablo M.

; Gonçalves, Pablo R.

; Shimabukuro, Paloma H.F.

; Grossi, Paschoal

; Rodrigues, Patrícia E. da S.

; Lima, Patricia O.V.

; Velazco, Paul

; Santos, Paula B. dos

; Araújo, Paula B.

; Silva, Paula K.R.

; Riccardi, Paula R.

; Garcia, Paulo C. de A.

; Passos, Paulo G.H.

; Corgosinho, Paulo H.C.

; Lucinda, Paulo

; Costa, Paulo M.S.

; Alves, Paulo P.

; Roth, Paulo R. de O.

; Coelho, Paulo R.S.

; Duarte, Paulo R.M.

; Carvalho, Pedro F. de

; Gnaspini, Pedro

; Souza-Dias, Pedro G.B.

; Linardi, Pedro M.

; Bartholomay, Pedro R.

; Demite, Peterson R.

; Bulirsch, Petr

; Boll, Piter K.

; Pereira, Rachel M.M.

; Silva, Rafael A.P.F.

; Moura, Rafael B. de

; Boldrini, Rafael

; Silva, Rafaela A. da

; Falaschi, Rafaela L.

; Cordeiro, Ralf T.S.

; Mello, Ramon J.C.L.

; Singer, Randal A.

; Querino, Ranyse B.

; Heleodoro, Raphael A.

; Castilho, Raphael de C.

; Constantino, Reginaldo

; Guedes, Reinaldo C.

; Carrenho, Renan

; Gomes, Renata S.

; Gregorin, Renato

; Machado, Renato J.P.

; Bérnils, Renato S.

; Capellari, Renato S.

; Silva, Ricardo B.

; Kawada, Ricardo

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; Siewert, Ricardo

; Brugnera, Ricaro

; Leschen, Richard A.B.

; Constantin, Robert

; Robbins, Robert

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; Cavichioli, Rodney R.

; Barros, Rodolfo C. de

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; Araujo, Rodrigo de O.

; Dios, Rodrigo de V.P.

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; Andena, Sérgio R.

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; Lima, Sheila P.

; Gadelha, Sian de S.

; Thiengo, Silvana C.

; Cohen, Simone C.

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; Caramaschi, Ulisses

; Pinheiro, Ulisses dos S.

; Pardiñas, Ulyses F.J.

; Maia, Valéria C.

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Zoologia (Curitiba)

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2024, Volume 41 elocation e24005

Abstract: En | Text: En | PDF: En

ABSTRACT The limited temporal completeness and taxonomic accuracy of species lists, made available in a traditional manner in scientific publications, has always represented a problem. These lists are invariably limited to a few taxonomic groups and do not represent up-to-date knowledge of all species and classifications. In this context, the Brazilian megadiverse fauna is no exception, and the Catálogo Taxonômico da Fauna do Brasil (CTFB) (http://fauna.jbrj.gov.br/), made public in 2015, represents a database on biodiversity anchored on a list of valid and expertly recognized scientific names of animals in Brazil. The CTFB is updated in near real time by a team of more than 800 specialists. By January 1, 2024, the CTFB compiled 133,691 nominal species, with 125,138 that were considered valid. Most of the valid species were arthropods (82.3%, with more than 102,000 species) and chordates (7.69%, with over 11,000 species). These taxa were followed by a cluster composed of Mollusca (3,567 species), Platyhelminthes (2,292 species), Annelida (1,833 species), and Nematoda (1,447 species). All remaining groups had less than 1,000 species reported in Brazil, with Cnidaria (831 species), Porifera (628 species), Rotifera (606 species), and Bryozoa (520 species) representing those with more than 500 species. Analysis of the CTFB database can facilitate and direct efforts towards the discovery of new species in Brazil, but it is also fundamental in providing the best available list of valid nominal species to users, including those in science, health, conservation efforts, and any initiative involving animals. The importance of the CTFB is evidenced by the elevated number of citations in the scientific literature in diverse areas of biology, law, anthropology, education, forensic science, and veterinary science, among others. publications problem uptodate up date classifications context exception (CTFB http//fauna.jbrj.gov.br/, httpfaunajbrjgovbr http //fauna.jbrj.gov.br/ , jbrj gov br (http://fauna.jbrj.gov.br/) 2015 Brazil 80 specialists 1 2024 133691 133 691 133,69 125138 125 138 125,13 82.3%, 823 82 3 (82.3% 102000 102 000 102,00 7.69%, 769 7 69 (7.69% 11000 11 11,00 . 3,567 3567 567 (3,56 2,292 2292 2 292 (2,29 1,833 1833 833 (1,83 1,447 1447 447 (1,44 1000 1,00 831 (83 628 (62 606 (60 520 (52 50 users science health biology law anthropology education others http//fauna.jbrj.gov.br/ faunajbrjgovbr //fauna.jbrj.gov.br (http://fauna.jbrj.gov.br/ 201 8 202 13369 13 133,6 12513 12 125,1 82.3% (82.3 10200 10 00 102,0 7.69% 76 6 (7.69 1100 11,0 3,56 356 56 (3,5 2,29 229 29 (2,2 1,83 183 83 (1,8 1,44 144 44 (1,4 100 1,0 (8 62 (6 60 52 (5 5 http//fauna.jbrj.gov.br (http://fauna.jbrj.gov.br 20 1336 133, 1251 125, 82.3 (82. 1020 0 102, 7.69 (7.6 110 11, 3,5 35 (3, 2,2 22 (2, 1,8 18 (1, 1,4 14 4 ( 82. (82 7.6 (7. 3, (3 2, (2 (1 7. (7

https://doi.org/10.1590/s1984-4689.v41.e24005

15.

Custom target-sequencing in triple-negative and luminal breast cancer from young Brazilian patients targetsequencing target sequencing triplenegative triple negative
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Serio, Pedro Adolpho de Menezes Pacheco

; Saccaro, Daniela Marques

; Gouvêa, Ana Carolina Ribeiro Chaves de

; Encinas, Giselly

; Maistro, Simone

; Pereira, Gláucia Fernanda de Lima

; Rocha, Vinícius Marques

; Souza, Larissa Dias de

; Silva, Viviane Jennifer da

; Katayama, Maria Lucia Hirata

; Folgueira, Maria Aparecida Azevedo Koike

Clinics

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2024, Volume 79 elocation 100479

Abstract: En | Text: En | PDF: En

Abstract Objectives: To identify somatic mutations in tumors from young women with triple-negative or luminal breast cancer, through targeted sequencing and to explore the cancer driver potential of these gene variants. Methods: A customized gene panel was assembled based on data from previous sequencing studies of breast cancer from young women. Triple-negative and luminal tumors and paired blood samples from young breast cancer patients were sequenced, and identified gene variants were searched for their driver potential, in databases and literature. Additionally, the authors performed an exploratory analysis using large, curated databases to evaluate the frequency of somatic mutations in this gene panel in tumors stratified by age groups (every 10 years). Results: A total of 28 young women had their tumoral tissue and blood samples sequenced. Using a customized panel of 64 genes, the authors could detect cancer drivers in 11/12 (91.7 %) TNBC samples and 11/16 (68.7 %) luminal samples. Among TNBC patients, the most frequent cancer driver was TP53, followed by NF1, NOTCH1 and PTPN13. In luminal samples, PIK3CA and GATA3 were the main cancer drivers, and other drivers were GRHL2 and SMURF2. CACNA1E was involved in both TN and luminal BC. The exploratory analysis also indicated a role for SMURF2 in luminal BC development in young patients. Conclusions: The data further indicates that some cancer drivers are more common in a specific breast cancer subtype from young patients, such as TP53 in TNBC and PIK3CA and GATA3 in luminal samples. These results also provide additional evidence that some genes not considered classical cancer-causing genes, such as CACNA1E, GRHL2 and SMURF2 might be cancer drivers in this age group. Objectives triplenegative triple negative Methods Triplenegative Triple sequenced literature Additionally large every 1 years. years . years) Results 2 6 1112 11 12 11/1 91.7 917 91 7 (91. % 1116 16 68.7 687 68 (68. TP NF1 NF NOTCH PTPN13 PTPN PIKCA PIK CA GATA GRHL SMURF CACNAE CACNA E Conclusions TP5 cancercausing causing group 111 11/ 91. 9 (91 68. (68 PTPN1 (9 (6 (

https://doi.org/10.1016/j.clinsp.2024.100479

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Glossary and search help

You can enrich your search in a very simple way. Use the search indexes combined with the connectors (AND or OR) and specify more your search.

For example, if you want to search for articles about
cases of dengue in Brasil in 2015, use:
ti:dengue and publication_year:2015 and aff_country:Brasil

See below the complete list of search indexes that can be used:

Index code	Element
ti	article title
au	author
kw	article keywords
subject	subject (title words, abstract and keywords)
ab	abstract
ta	journal short title (e.g. Cad. Saúde Pública)
journal_title	journal full title (e.g. Cadernos de Saúde Pública)
la	publication language code (e.g. pt - Portuguese, es - Spanish)
type	document type
pid	publication identifier
publication_year	publication year of publication
sponsor	sponsor
aff_country	country code of the author's affiliation
aff_institution	author affiliation institution
volume	article volume
issue	article issue
elocation	elocation
doi	DOI number
issn	journal ISSN
in	SciELO colection code (e.g. scl - Brasil, col - Colômbia)
use_license	article usage license code

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