ABSTRACT Purpose: This study aimed to compare the safety and effectiveness of intraocular pressure reduction between micropulse transscleral cyclophotocoagulation and “slow cook” transscleral cyclophotocoagulation in patients with refractory primary open-angle glaucoma. Methods: We included patients with primary open angle glaucoma with at least 12 months of follow-up. We collected and analyzed data on the preoperative characteristics and postoperative outcomes. The primary outcomes were a reduction of ≥20% of the baseline value (criterion A) and/or intraocular pressure between 6 and 21 mmHg (criterion B). Results: We included 128 eyes with primary open-angle glaucoma. The preoperative mean intraocular pressure was 25.53 ± 6.40 and 35.02 ± 12.57 mmHg in the micropulse- and “slow cook” transscleral cyclophotocoagulation groups, respectively (p<0.001). The mean intraocular pressure was reduced significantly to 14.33 ± 3.40 and 15.37 ± 5.85 mmHg in the micropulse- and “slow cook” transscleral cyclophotocoagulation groups at the last follow-up, respectively (p=0.110). The mean intraocular pressure reduction at 12 months was 11.20 ± 11.46 and 19.65 ± 13.22 mmHg in the micropulse- and “slow cook” transscleral cyclophotocoagulation groups, respectively (p<0.001). The median preoperative logMAR visual acuity was 0.52 ± 0.69 and 1.75 ± 1.04 in the micropulse- and “slow cook” transscleral cyclophotocoagulation groups, respectively (p<0.001). The mean visual acuity variation was −0.10 ± 0.35 and −0.074 ± 0.16 in the micropulse- and “slow cook” transscleral cyclophotocoagulation, respectively (p=0.510). Preoperatively, the mean eye drops were 3.44 ± 1.38 and 2.89 ± 0.68 drugs in the micropulse- and “slow cook” transscleral cyclophotocoagulation groups, respectively (p=0.017), but those were 2.06 ± 1.42 and 1.02 ± 1.46 at the end of the study in the “slow cook” and micropulse transscleral cyclophotocoagulation groups, respectively (p<0.001). The success of criterion A was not significant between both groups. Compared with 11 eyes (17.74%) in the “slow cook” transscleral cyclophotocoagulation group, 19 eyes (28.78%) in the micropulse transscleral cyclophotocoagulation group showed complete success (p=0.171). For criterion B, 28 (42.42%) and 2 eyes (3.22%) showed complete success after micropulse- and “slow cook” transscleral cyclophotocoagulation, respectively (p<0.001). Conclusion: Both techniques reduced intraocular pressure effectively. Purpose slow cook openangle Methods 1 followup. followup follow up. up follow-up 20 ≥20 andor or B. B . B) Results 2553 25 53 25.5 640 40 6.4 3502 35 02 35.0 1257 57 12.5 p<0.001. p0001 p p<0.001 0 001 (p<0.001) 1433 14 33 14.3 340 3 3.4 1537 15 37 15.3 585 5 85 5.8 followup, up, p=0.110. p0110 p=0.110 110 (p=0.110) 1120 11.2 1146 46 11.4 1965 65 19.6 1322 13 22 13.2 052 52 0.5 069 69 0.6 175 75 1.7 104 04 1.0 010 10 −0.1 035 0.3 0074 074 −0.07 016 16 0.1 p=0.510. p0510 p=0.510 510 (p=0.510) Preoperatively 344 44 138 38 1.3 289 89 2.8 068 68 p=0.017, p0017 p=0.017 , 017 (p=0.017) 206 06 2.0 142 42 1.4 102 146 17.74% 1774 17 74 (17.74% 28.78% 2878 78 (28.78% p=0.171. p0171 p=0.171 171 (p=0.171) 42.42% 4242 (42.42% 3.22% 322 (3.22% Conclusion effectively ≥2 255 25. 64 4 6. 350 35. 125 12. p000 p<0.00 00 (p<0.001 143 14. 34 3. 153 15. 58 8 5. p011 p=0.11 (p=0.110 112 11. 114 196 19. 132 13. 05 0. 7 1. 01 −0. 03 007 07 −0.0 p051 p=0.51 51 (p=0.510 2. p001 p=0.01 (p=0.017 17.74 177 (17.74 28.78 287 (28.78 p017 p=0.17 (p=0.171 42.42 424 (42.42 3.22 32 (3.22 ≥ p00 p<0.0 (p<0.00 p01 p=0.1 (p=0.11 −0 p05 p=0.5 (p=0.51 p=0.0 (p=0.01 17.7 (17.7 28.7 (28.7 (p=0.17 42.4 (42.4 3.2 (3.2 p0 p<0. (p<0.0 p=0. (p=0.1 − (p=0.5 (p=0.0 17. (17. 28. (28. 42. (42. (3. p<0 (p<0. p=0 (p=0. (17 (28 (42 (3 p< (p<0 p= (p=0 (1 (2 (4 ( (p< (p= (p

RESUMO: O estudo foi realizado em um ovino, fêmea, de três anos de idade, da raça santa inês, procedente de uma propriedade localizada do município de Santo Antônio de Tauá, oeste do Pará. O animal acometido tinha histórico de exoftalmia no olho esquerdo, secreção nasal e dificuldade respiratória há mais de três meses. Ao exame físico o animal apresentava baixo escore corporal, apatia, assimetria facial unilateral, moderada exoftalmia unilateral esquerda, dispneia mista e exsudação nasal serossanguinolenta profusa unilateral. À necropsia, foi observada grande massa nasal, predominantemente branco-amarelada com áreas vermelho enegrecidas, de superfície irregular, finamente granular, úmida e friável. A massa invadia desde a junção mucocutânea do nariz esquerdo até as coanas, se infiltrava pelos seios nasais frontais, placa cribiforme e alcançava as meninges e a porção frontal do cérebro. À microscopia da superfície do epitélio nasal notou-se severa destruição dos cornetos e dos epitélios, evidenciada por extensas áreas de necrose com muitos debris celulares, ulceração e infecção bacteriana secundária. No sistema nervoso central (SNC) havia meningite piogranulomatosa com acentuada congestão de vasos, focos de necrose e inflamação granulomatosa. O diagnóstico de rinite granulomatosa de origem micótica associada ao fungo Conidiobolus lamprauges foi baseado nos achados da imuno-histoquímica. RESUMO ovino fêmea idade inês Tauá Pará meses corporal apatia esquerda necropsia brancoamarelada branco amarelada enegrecidas irregular granular friável coanas frontais cérebro notouse notou epitélios celulares secundária SNC (SNC vasos imunohistoquímica. imunohistoquímica imuno histoquímica. histoquímica imuno-histoquímica

ABSTRACT: The study was conducted on a 3-year-old female Santa Inês sheep from a property located in the municipality of Santo Antônio de Tauá, west of Pará. The affected animal had a history of exophthalmos in the left eye, nasal discharge, and breathing difficulty for more than three months. On physical examination, the animal had a low body score, apathy, unilateral facial asymmetry, moderate unilateral left exophthalmos, mixed dyspnea and unilateral profuse serosanguinous nasal discharge. At necropsy, a large nasal mass was observed, predominantly yellowish-white with blackish-red areas, with an irregular, finely granular, moist, and friable surface. The mass invaded from the mucocutaneous junction of the left nostril to the choanae, infiltrated the frontal sinuses, the cribiform plate, and reached the meninges and the frontal portion of the brain. Microscopy of the surface of the nasal epithelium showed severe destruction of the turbinates and epithelia, evidenced by extensive areas of necrosis with a large amount of cellular debris, ulceration, and secondary bacterial infection. In the central nervous system there was pyogranulomatous meningitis with marked vessel congestion, as well as foci of necrosis and granulomatous inflammation. Immunohistochemistry showed intense staining of numerous intralesional hyphae for antibodies against Conidiobolus lamprauges. The diagnosis of granulomatous rhinitis of mycotic origin associated with the Conidiobolus lamprauges was based on epidemiological, clinical-pathological, and immunohistochemical data. ABSTRACT 3yearold yearold 3 year old Tauá Pará eye discharge months examination score apathy asymmetry necropsy observed yellowishwhite yellowish white blackishred blackish red irregular granular moist choanae sinuses plate brain epithelia debris ulceration infection congestion inflammation epidemiological clinicalpathological, clinicalpathological clinical pathological, pathological clinical-pathological data

ABSTRACT The aim of this study was to characterise the lignocellulosic fractions of pruning waste from tree species showing potential for furniture production in Acaraú, Ceará. The experiment was conducted in a completely randomised, split-plot design, with the plots corresponding to two water regimes (irrigated for one year and irrigated for three years) and the sub-plots to eight tree species, with three replications. The chemical attributes were determined after seven years. Except for the insoluble lignin content, there was a significant effect from the different species in terms of the chemical properties of the wood. The results for the lignocellulosic fractions show the possibility of developing technological ways of adding value to these waste products, especially considering their lignin content. The different species also showed potential for use in producing cellulose pulp, with the exception of Handroanthus impetiginosus due to its high ash content. The results of this study offer new perspectives for future research into the use of forestry waste. Acaraú Ceará randomised splitplot split plot design years subplots sub replications content wood products pulp

Resumo Introdução: O objetivo deste estudo foi investigar o papel do fenofibrato, um agonista do receptor ativado por proliferadores de peroxissoma-α, na lesão renal induzida por obesidade (lipotoxicidade) em camundongos submetidos à uninefrectomia. Métodos: Camundongos C57BL/6 foram submetidos a uninefrectomia e cirurgias simuladas (sham) e alimentados com dietas normocalóricas ou rica em gordura. Após 10 semanas, os camundongos obesos receberam fenofibrato a 0,02% por 10 semanas. Avaliamos função e morfologia renal, bem como níveis de mediadores inflamatórios e fibróticos e marcadores do metabolismo lipídico. Resultados: Camundongos alimentados com dieta rica em gordura desenvolveram obesidade e hiperlipidemia características, com subsequente acúmulo de lipídios e danos renais, incluindo expansão mesangial, fibrose intersticial, inflamação e proteinúria. Essas alterações foram maiores em camundongos obesos uninefrectomizados do que em camundongos obesos sham. O tratamento com fenofibrato preveniu hiperlipidemia e lesões glomerulares, reduziu o acúmulo de lipídios, melhorou a disfunção renal e atenuou a inflamação e fibrose renal. Além disso, o tratamento com fenofibrato reduziu a expressão no tecido renal do inibidor do ativador do plasminogênio-1, da proteína quimiotática de monócitos-1 e a expressão local do fator de crescimento de fibroblastos-21. Conclusão: A ativação do receptor ativado por proliferadores de peroxissoma-α pelo fenofibrato, com subsequente lipólise, atenuou lesões glomerulares e tubulointersticiais induzidas por lipotoxicidade renal, protegendo, assim, os rins de camundongos uninefrectomizados contra lesões induzidas por obesidade. Os achados do estudo sugerem uma via na ação farmacológica do fenofibrato, fornecendo insights sobre os mecanismos envolvidos no dano renal causado pela obesidade em doadores renais. Introdução peroxissomaα, peroxissomaα peroxissoma α, α (lipotoxicidade Métodos C57BL6 CBL C57BL 6 C BL C57BL/ sham (sham 1 semanas 002 0 02 0,02 lipídico Resultados características renais mesangial intersticial proteinúria disso plasminogênio1, plasminogênio1 plasminogênio 1, plasminogênio-1 monócitos1 monócitos monócitos- fibroblastos21. fibroblastos21 fibroblastos 21. 21 fibroblastos-21 Conclusão lipólise protegendo assim 00 0,0 plasminogênio- fibroblastos2 2 fibroblastos-2 0, fibroblastos-

Abstract Introduction: The objective of this study was to investigate the role of fenofibrate, a peroxisome proliferator-activated receptor-α agonist, in obesity-induced kidney damage (lipotoxicity) in mice with uninephrectomy. Methods: C57BL/6 mice underwent uninephrectomy and sham surgeries and were fed normocaloric or high-fat diets. After 10 weeks, obese mice were administered 0.02% fenofibrate for 10 weeks. Kidney function and morphology were evaluated, as well as levels of inflammatory and fibrotic mediators and lipid metabolism markers. Results: High-fat diet-fed mice developed characteristic obesity and hyperlipidemia, with subsequent renal lipid accumulation and damage, including mesangial expansion, interstitial fibrosis, inflammation, and proteinuria. These changes were greater in obese uninephrectomy mice than in obese sham mice. Fenofibrate treatment prevented hyperlipidemia and glomerular lesions, lowered lipid accumulation, ameliorated renal dysfunction, and attenuated inflammation and renal fibrosis. Furthermore, fenofibrate treatment downregulated renal tissue expression of plasminogen activator inhibitor-1, monocyte chemoattractant protein-1, and local expression of fibroblast growth factor-21. Conclusion: Peroxisome proliferator-activated receptor-α activation by fenofibrate, with subsequent lipolysis, attenuated glomerular and tubulointerstitial lesions induced by renal lipotoxicity, thus protecting the kidneys of uninephrectomy mice from obesity-induced lesions. The study findings suggest a pathway in the pharmacological action of fenofibrate, providing insight into the mechanisms involved in kidney damage caused by obesity in kidney donors. Introduction proliferatoractivated proliferator activated receptorα receptor α agonist obesityinduced lipotoxicity (lipotoxicity Methods C57BL6 CBL C57BL 6 C BL C57BL/ highfat high fat diets 1 weeks 002 0 02 0.02 evaluated markers Results Highfat High dietfed diet expansion fibrosis proteinuria dysfunction Furthermore inhibitor1, inhibitor1 inhibitor 1, inhibitor-1 protein1, protein1 protein protein-1 factor21. factor21 factor 21. 21 factor-21 Conclusion lipolysis donors 00 0.0 inhibitor- protein- factor2 2 factor-2 0. factor-

Abstract A recent case in Argentina, where a child was generated through in Medically Assisted Procreation and was not the couple's biological daughter, reopened discussions about possible errors involving reproductive techniques. In this article, based on a bibliographical and documentary review, in addition to the responsibility of the centers that perform the procedure and the professionals involved, we deal with something more delicate: the rights of those who are born by “carelessness”, whose paternity is unknown or questioned or even rejected, after life has been generated in an unconventional way. Technological advances in human reproduction are undeniable and, in general, include couples prevented from having biological children without the use of such techniques, as is the case in Portugal and Brazil. However, life and ethics must be linked so that everyone's rights are respected. And, more specifically, so that the person does not have their life violated at birth, growing up amid legal disputes and rejection of parents who are faced with DNA test results that confirm the absence of the expected genetic bond. In such cases, paternity can be disputed, even by the “owners” of eggs, sperm or embryos frozen and used by mistake, to generate, by reflex, the existence of orphan newborn children, without parents.

Resumo Caso recente na Argentina, onde uma criança foi gerada por meio de Procriação Medicamente Assistida e não era filha biológica do casal, reabriu as discussões sobre possíveis erros envolvendo técnicas reprodutivas. Neste artigo, feito a partir de revisão bibliográfica e documental, para além da responsabilidade dos centros que realizam o procedimento e dos profissionais envolvidos, tratamos de algo mais delicado: os direitos de quem nasce por “descuido”, tendo a paternidade desconhecida ou questionada ou até mesmo rejeitada, após a vida ter sido gerada de modo não convencional. Os avanços tecnológicos na área da reprodução humana são inegáveis e, de modo geral, contemplam casais impedidos de ter filhos biológicos sem o uso de tais técnicas, como se verifica em Portugal e no Brasil. Entretanto, vida e ética devem estar atreladas para que os direitos de todos sejam respeitados. E, mais especificamente, para que a pessoa não tenha sua vida violada ao nascer, crescendo em meio a disputas judiciais e rejeição de pais que se depararam com resultados de testes de DNA que confirmam a inexistência de esperado vínculo genético. Em tais casos, a paternidade pode ser contestada, inclusive pelos “donos” de óvulos, esperma ou embriões congelados e utilizados por engano, a gerar, por reflexo, a existência de nascituros órfãos, sem pais.

Resumen El Cerrado alberga una rica biodiversidad y aún enfrenta diversas presiones antropogénicas, una situación alarmante que justifica estudios de inventario de fauna, especialmente de insectos, a menudo pasados por alto en tales esfuerzos. Además, muchos lugares dentro del Cerrado carecen de información sobre la odonatofauna, incluídas las Unidades de Conservación (UC), consideradas las principales herramientas para la conservación de la biodiversidad en Brasil. El objetivo de nuestro estudio es informar sobre la comunidad de odonatos que se encuentra en la porción de Minas Gerais del Parque Nacional Grande Sertão Veredas (PNGSV), el estado de conservación de las especies, información taxonómica para algunos taxones y comparar la comunidad de odonatos durante las estaciones húmeda y seca. El estudio se realizó de septiembre de 2022 a abril de 2023, con un total de 576 horas de muestreo. Recopilamos 601 ejemplares de 83 especies, destacando dos nuevas especies (una recientemente descrita y otra por describirse en otro lugar), ocho nuevos registros para el estado y el redescubrimiento de las especies Progomphus geijskesi Needham, 1944, recolectada por primera vez en Brasil desde 1918, y Argia botacudo Calvert, 1909, conocida anteriormente solo por el material tipo. La riqueza significativa muestreada, los nuevos taxones, los nuevos registros y la presencia de especies en riesgo de extinción refuerzan la relevancia del Cerrado como un hotspot global. También subraya la importancia de las UC como herramienta para garantizar la protección de las comunidades de odonatos en Brasil y destaca la necesidad de fortalecer las políticas públicas para garantizar inversiones y fomentar futuros recursos financieros para la protección de la biota brasileña, especialmente para llevar a cabo más estudios de inventario en el Cerrado.

Abstract The Cerrado harbors rich biodiversity and yet faces various anthropogenic pressures, an alarming situation that justifies fauna inventory studies, particularly insects, often overlooked in such endeavors. Additionally, many locations within the Cerrado lack information about the odonatofauna, including Conservation Units (CUs), considered the main tools for biodiversity conservation in Brazil. The objective of our study is to report the Odonata community occurring in the Minas Gerais portion of the Parque Nacional Grande Sertão Veredas (PNGSV), the conservation status of species, taxonomic information for some taxa, and compare the Odonata community along wet and dry seasons. The study was conducted from September 2022 to April 2023, with a total of 576 hours of sampling. We collected 601 specimens from 83 species, highlighting two new species (one recently described and other to be described elsewhere), eight new records for the state, and the rediscovery of the species Progomphus geijskesi Needham, 1944, collected for the first time in Brazil since 1918, and Argia botacudo Calvert, 1909, previously known only from the type material. The significant richness sampled, new taxa, new records, and the presence of species at some risk of extinction reinforce the Cerrado's relevance as a global hotspot. It also underscores the importance of CUs as a tool to ensure the protection of Odonata communities in Brazil and highlights the need to strengthen public policies to guarantee investments and foster future financial resources for the protection of Brazilian biota, especially for conducting more inventory studies in the Cerrado.

Abstract A continuous increase in levels of atmospheric pollution and emission restrictions has forced scientists and engineers to adopt new strategies to improve and develop internal combustion engines. One strategy is based on the development of new simulation methodologies using computational fluid dynamic (CFD) techniques, proposed in the present article. In this study,the dynamic loop methodology with ANSYS Fluent code is proposed to perform the numerical simulation ofa four-stroke spark ignition engine. The complexity of the real case was first simplified with three-dimensional CAD geometry, which was then discretized in ANSYS Meshing, whereby a hybrid mesh was created using prismatic and tetrahedral elements. Simulations for in-cylinder analyses were performed in cold flow and employing common flow parameters, such as swirl and tumble. The mesh quality results were classified as good or excellent, being higher than 0.79 for orthogonal quality criteria and lower than 0.36 for skewness criteria. Turbulent effects were introduced concerning the opening and closing of the valves. It was found that the turbulence increases during the intake stroke up to 90°, and during the power stroke, wherein the of the piston bowl, had a great contributionthat can be seen from the swirl and tumble profile for the engine cycle. In the case of the turbulence intensity, a sharp increase was registered during the admission step up to 90°, at which point the turbulence intensity was 4.0. It canbe concluded that this is an innovative approach, capable of simulating the engine motion profile in cold flow. engines CFD (CFD techniques article studythe study fourstroke four threedimensional three dimensional geometry Meshing elements incylinder cylinder parameters excellent 079 0 79 0.7 036 36 0.3 valves 90 90° bowl cycle 40 4 4.0 approach 07 7 0. 03 3 9 4.

ABSTRACT Management of Quilombola systems are primitive agricultural systems based on the ancestral knowledge of Afro-Brazilian enslaved people. Here, the aim was to understand the impact of these primitive farming methods on the distribution of available nitrogen (N) forms in the soil profile of two Brazilian Cerrado phytophysiognomies. The soil was sampled in Cerradão (high Cerrado) and Cerrado Stricto sensu (low Cerrado) at six soil depths (0-10, 10-20, 20-30, 30-40, 40-50, and 50-60 cm). The following management systems were considered: pasture (PP1 and PP2), maize cultivation (M1 and M2), citrus-cassava intercropping (T1), and citrus monoculture (T2). In addition, the soil was sampled in the native area of Cerradão (NC1) and Cerrado Stricto sensu (NC2). Three N forms were determined: i) available nitrogen (Av-N), ii) ammonium (NH4+-N) and iii) nitrate (NO3–-N) contents. The Av-N content decreased with increasing soil depth only in NC1 and NC2. The NO3–-N content was similar at all soil depths for maize and pasture, while the content decreased at soil depth for NC1, NC2, and T1. NH4+-N was similar in M2 and PP2, but it increased in T2, ranging from 6.17 mg kg–1 to 17.54 mg kg–1. Overall, the dynamics of available N forms varied according to the Cerrado phytophysiognomy and the management systems and NO3–-N was the most constant N form in the soil profile. Therefore, although the management of Quilombola systems is less intensive, they negatively affect the dynamics and N availability, mainly where management is less conservative, that is, in maize and citrus monocultures. AfroBrazilian Afro people Here (N phytophysiognomies high low 010, 010 0 10, 10 (0-10 1020, 1020 20, 20 10-20 2030, 2030 30, 30 20-30 3040, 3040 40, 40 30-40 4050, 4050 50, 50 40-50 5060 60 50-6 cm. cm . cm) considered PP1 PP (PP PP2 , PP2) M1 M (M M2, M2) citruscassava cassava T1, T1 T (T1) T2. T2 (T2) addition NC (NC1 NC2 (NC2) determined i AvN, AvN Av (Av-N) ii NH4+N NH4N NHN NH4+ NH4 NH (NH4+-N iii NO3–N NO3N NON NO3– NO3 NO (NO3–-N contents 617 6 17 6.1 kg1 kg 1 kg– 1754 54 17.5 Overall Therefore intensive availability conservative monocultures 01 (0-1 102 2 10-2 203 3 20-3 304 4 30-4 405 5 40-5 506 50- (T1 (T2 (NC (NC2 (Av-N 61 6. 175 17. (0- 10- 20- 30- 40- (T (0 (

ABSTRACT The use of carp pituitary extract (CPE) in fish reproduction may have drawbacks, whereas analogues of mammalian (aGnRHm) or salmon (aGnRHs) gonadotropins containing dopamine inhibitor (DI) may offer greater advantages. The objective of this study was to evaluate the effect of different hormone inducers on the reproduction of Prochilodus brevis males. A total of 44 specimens of P. brevis were divided into six groups, namely, CPE 4.0 mg; saline solution 1.0 mL; aGnRHm + DI 0.3 mg and 0.5 mg; and aGnRHs + DI 0.25 mL and 0.35 mL kg-1 of live weight. The number of ejaculates, seminal volume, curvilinear velocity (VCL), straight-line velocity (VSL), average path velocity (VAP), sperm morphology and concentration, and membrane and DNA integrity were determined. Sample normality was examined using the Shapiro-Wilk test, and homogeneity using the Levene test. Analysis of variance (ANOVA) was conducted, followed by Tukey's test to compare means, with statistical significance set at p < 0.05. Notably, all fish induced with CPE 4.0 and aGnRHm + DI demonstrated ejaculation, yielding a greater seminal volume. Sperm concentration under aGnRHs + DI 0.35 exceeded that with aGnRHm + DI 0.3 and CPE 4.0. Regarding velocity, aGnRHm + DI 0.3 outperformed aGnRHs + DI 0.35 in VCL, while aGnRHm + DI 0.3 and 0.5 and aGnRHs + DI 0.25 led to higher VSL than aGnRHs 0.35. Additionally, VAP was elevated under aGnRHm + DI 0.3 and CPE, in contrast to aGnRHs + DI 0.35. Improved sperm morphology was observed with aGnRHm + DI 0.5 and aGnRHs + DI 0.25 compared to aGnRHm + DI 0.3. The remaining parameters did not differ significantly. (CPE drawbacks (aGnRHm (aGnRHs (DI advantages males 4 P groups namely 40 0 4. 10 1 1. 03 3 0. 05 5 025 25 0.2 035 35 kg1 kg kg- weight ejaculates volume VCL , (VCL) straightline straight line VSL, (VSL) VAP, (VAP) determined ShapiroWilk Shapiro Wilk ANOVA (ANOVA conducted Tukeys Tukey s means 005 0.05 Notably ejaculation Additionally significantly 02 2 (VCL (VSL (VAP 00 0.0

RESUMO: O objetivo deste trabalho foi avaliar o desempenho agronômico por meio de modelos mistos e determinar a divergência genética entre genótipos de aveia preta. O experimento foi conduzido na Universidade Federal de Santa Maria, campus de Frederico Westphalen/RS. Catorze genótipos de aveia preta foram avaliados, sendo 11 linhagens desenvolvidas pelo Programa de Melhoramento da Universidade e três cultivares comercias (IAPAR 61, UPFA 21 - Moreninha e IPR Cabocla). Foram avaliadas características agronômicas quantitativas relacionadas ao porte, ciclo e produtividade de massa seca e de sementes; e 19 características qualitativas, sendo estes descritores morfológicos. Os resultados mostraram que as linhagens UFSMFW 2-05 e UFSMFW 2-07 se destacam com características como ciclo precoce, elevada produtividade de massa seca e de sementes. A análise de divergência revelou a formação de três grupos distintos, indicando presença de variabilidade. Os resultados demonstram o potencial de desenvolvimento de novas cultivares de aveia preta, apresentando precocidade e boa produtividade de sementes. RESUMO Maria WestphalenRS Westphalen RS Westphalen/RS avaliados 1 IAPAR 61 2 Cabocla. Cabocla . Cabocla) porte sementes qualitativas morfológicos 205 05 2-0 207 07 precoce distintos variabilidade 6 20 0 2-

ABSTRACT: This research evaluated the agronomic performance through mixed models, and determined the genetic divergence between black oat genotypes. The experiment was carried out at Federal University of Santa Maria, Frederico Westphalen/RS. Fourteen black oat genotypes were evaluated, being 11 lines developed by Breeding Program of University, and three commercial cultivars (IAPAR 61, UPFA 21 - Moreninha and, IPR Cabocla). We evaluated quantitative traits associated to plant height, cycle, dry mass yield and seeds yield; and 19 qualitative traits, being these morphological descriptors. The results showed that lines UFSMFW 2-05 and UFSMFW 2-07 stand out with characteristics such as early cycle, higher dry mass and grain yield. Divergence analysis revealed the formation of three distinct groups, indicating the presence of variability. These results suggested the potential for the development of new cultivars of black oat, presenting early cycle and good grain yield. ABSTRACT models Maria WestphalenRS Westphalen RS Westphalen/RS 1 IAPAR 61 2 Cabocla. Cabocla . Cabocla) height descriptors 205 05 2-0 207 07 groups variability 6 20 0 2-

ABSTRACT Agroecological management is considered a model of sustainable agriculture that offers social, environmental and economic benefits. The hypotheses of this study were that agroecological production systems can promote changes in the physical fractions of soil organic matter (SOM) associated with aggregates of different origins, and that the greater diversity of plant species in the production system may favour an increase in the carbon concentration of these aggregates. The aim of this study was to a) determine the mass of the free light fraction (FLF), intra-aggregate light fraction (ILF) and light organic matter fraction (LOM) of biogenic and physiogenic soil aggregates; and b) quantify the organic carbon content of the three light SOM fractions and the residual particulate SOM fraction. Five production systems were evaluated: AgF - Agroforestry system; CSun - Coffee grown in full sun; CSha - Coffee grown in shade; FLE - Flemingia grown in alleys; and NT - No-tillage. The aggregates were separated, identified and classified according to their origin or formation pathway into biogenic (formed by biological processes) or physiogenic aggregates (resulting from chemical and physical actions). From these, the mass and carbon content of the FLF, ILF, LOM and residual particulate fractions were quantified. The greater diversity of plant species found in the AgF system has not yet favoured an increase in the carbon content of the aggregates. The longer set-up time and the management practices of the CSun system has led to an increase in the carbon content of the organic fractions of the aggregates (3.44-1.63 g kg-1 for C-LOM; 1.93-1.13 g kg-1 for C-FLF). The lowest overall mean values for LOM and ILF were found mainly in the aggregates of the NT system (1.22-1.67 and 1.55-2.20 g kg-1, respectively), being associated with the shorter time and greater mobilisation of the arable layer. Biogenic aggregation afforded the highest overall mean values for LOM, and increased the mass of the light fractions (15.5%-27.8% for FLF; 23.4%-8.0% for ILF) and the carbon in the C-LOM, C-FLF and residual particulate fractions (42.3%, 12.9%, and 35.0%, respectively) in the surface layer, suggesting an improvement in soil quality. social benefits (SOM origins FLF , (FLF) intraaggregate intra aggregate (ILF (LOM b evaluated sun shade alleys Notillage. Notillage No tillage. tillage No-tillage separated formed processes resulting actions. actions . actions) quantified setup set up 3.441.63 344163 3.44 1.63 3 44 1 63 (3.44-1.6 kg1 kg kg- CLOM C C-LOM 1.931.13 193113 1.93 1.13 93 13 1.93-1.1 CFLF. CFLF C-FLF) 1.221.67 122167 1.22 1.67 22 67 (1.22-1.6 1.552.20 155220 1.55 2.20 55 2 20 1.55-2.2 kg1, 1, respectively, respectively layer 15.5%27.8% 155278 15.5% 27.8% 15 5 27 8 (15.5%-27.8 23.4%8.0% 23480 23.4% 8.0% 23 4 0 23.4%-8.0 CLOM, 42.3%, 423 42 (42.3% 129 12 9 12.9% 350 35 35.0% quality (FLF 441 3.441.6 34416 344 3.4 163 1.6 6 (3.44-1. 931 1.931.1 19311 193 1.9 113 1.1 1.93-1. 221 1.221.6 12216 122 1.2 167 (1.22-1. 552 1.552.2 15522 155 1.5 220 2.2 1.55-2. 15.5%27.8 15527 15.5 278 27.8 (15.5%-27. 23.4%8.0 2348 234 23.4 80 8.0 23.4%-8. 42.3% (42.3 12.9 35.0 3.441. 3441 34 3. 16 1. (3.44-1 1.931. 1931 19 11 1.93-1 1.221. 1221 (1.22-1 1.552. 1552 2. 1.55-2 15.5%27. 15. 27. (15.5%-27 23.4%8. 23. 8. 23.4%-8 42.3 (42. 12. 35. 3.441 (3.44- 1.931 1.93- 1.221 (1.22- 1.552 1.55- 15.5%27 (15.5%-2 23.4%8 23.4%- 42. (42 (3.44 (1.22 15.5%2 (15.5%- (4 (3.4 (1.2 (15.5% ( (3. (1. (15.5 (3 (1 (15. (15

Resumo O presente artigo tem por objetivo levantar o estado da arte sobre Inovação Tecnológica e/ou de Processos com foco na Agricultura Orgânica, por meio de uma revisão sistemática de literatura (RSL), classificada como exploratória, descritiva e com abordagem qualitativa. Para tal intento, foi utilizado o protocolo descrito por Cronin et al. (2008). Após a aplicação dos critérios de inclusão e exclusão foram selecionados e analisados 29 artigos na base de dados Web of Science. Os resultados indicaram predominância de pesquisas teórico-empíricas que integram abordagens qualitativa e quantitativa. Adicionalmente, foram mapeados os principais autores, bem como instituições e periódicos com maior quantidade de publicações na área pesquisada. Evidenciou-se que as autoras Leila Amaral Gontijo (UFSC), Larissa Maas (UFSC) e Rosane Malvestiti (UFSC) são as que mais aparecem na lista entre os 29 artigos examinados na pesquisa. A instituição com maior destaque nas publicações é a Universidade Federal de Santa Catarina (UFSC). A análise de conteúdo indicou que os ecossistemas de inovação podem ser construídos por meio de uma densa rede de relações, que auxilia no desenvolvimento e difusão do conhecimento aliado a um forte senso de territorialidade. Por fim, apresenta-se agenda de pesquisas futuras para avanços nesse campo de conhecimento. eou ou Orgânica RSL, RSL , (RSL) exploratória intento al 2008. 2008 . (2008) 2 Science teóricoempíricas teórico empíricas quantitativa Adicionalmente autores pesquisada Evidenciouse Evidenciou se UFSC, UFSC (UFSC pesquisa UFSC. relações territorialidade fim apresentase apresenta (RSL 200 (2008 20 (200 (20 (2 (

Abstract This article aims to survey the state of the art on Technological and/or Process Innovation with a focus on Organic Agriculture, through a systematic literature review (SLR), classified as exploratory, descriptive and with a qualitative approach. For this purpose, the protocol described by Cronin et al. (2008) was used. After applying the inclusion and exclusion criteria, 29 articles were selected and analyzed in the Web of Science database. The results indicated a predominance of theoretical-empirical research that integrates qualitative and quantitative approaches. Additionally, the main authors were mapped, as well as institutions and journals with the highest number of publications in the researched area. It was evident that the authors Leila Amaral Gontijo (UFSC), Larissa Maas (UFSC) and Rosane Malvestiti (UFSC) are the ones that most appear in the list among the 29 articles examined in the research. The most prominent institution in the publications is the Universidade Federal de Santa Catarina (UFSC). Content analysis indicated that innovation ecosystems can be built through a dense network of relationships, which helps in the development and dissemination of knowledge combined with a strong sense of territoriality. Finally, an agenda for future research is presented for advances in this field of knowledge. andor or Agriculture SLR, SLR , (SLR) exploratory approach purpose al 2008 (2008 used criteria 2 database theoreticalempirical theoretical empirical approaches Additionally mapped area UFSC, UFSC (UFSC UFSC. . relationships territoriality Finally (SLR 200 (200 20 (20 (2 (

RESUMO Objetivo: Revisar sistematicamente a literatura em busca das intervenções e indicações nutricionais mais adequadas e eficazes para o tratamento nutricional de crianças e adolescentes com paralisia cerebral (PC). Fontes de dados: Esta revisão foi conduzida de acordo com as diretrizes Preferred Reporting Items for Systematic Reviews and Meta-Analyses — PRISMA. Os artigos foram selecionados em sete bases de dados (Cochrane, Literatura Latino-Americana e do Caribe em Ciências da Saúde — Lilacs, Embase, United States National Library of Medicine — PubMed, Scientific Electronic Library Online — SciELO, Scopus, and Web of Science). Foram incluídos estudos de um grupo pediátrico (zero a 18 anos) com diagnóstico de PC e a estratégia de busca incluiu os descritores: “children” OR “childhood” AND “nutritional therapy” OR “nutritional intervention” OR “nutrition” OR “nutritional support” OR “diet” AND “cerebral palsy” OR “cerebral injury”. A qualidade metodológica foi avaliada utilizando a lista de verificação para estudos transversais analíticos, escala Newcastle-Ottawa ou ferramenta da Cochrane Collaboration, para ensaios clínicos. Síntese dos dados: Quinze estudos (n=658) publicados de 1990 a 2020 preencheram os critérios de inclusão. Todos tiveram baixo risco de viés. Os dados mostraram que crianças e adolescentes com PC apresentam pior estado nutricional do que os normalmente desenvolvidos. Aqueles que receberam suplementação nutricional hipercalórica e hiperproteica beneficiaram-se de seu uso. Estudos demonstram que a nutrição enteral deve ser considerada quando as necessidades nutricionais não são supridas pela dieta oral, principalmente nos casos em que as funções oromotoras estão prejudicadas. Além disso, houve relação direta entre a consistência dos alimentos, o nível de função motora e o estado nutricional. Conclusões: Crianças e adolescentes com PC têm maior risco de desnutrição. O uso de suplementação nutricional pode auxiliar no ganho de peso desses pacientes. Além disso, a nutrição enteral e a modificação da textura dos alimentos têm sido artifícios utilizados para a melhora do estado nutricional neste grupo. Objetivo PC. . (PC) MetaAnalyses Meta Analyses PRISMA Cochrane, (Cochrane LatinoAmericana Latino Americana Lilacs Embase PubMed SciELO Scopus Science. Science Science) zero 1 anos descritores children “children childhood “childhood nutritional therapy intervention nutrition “nutrition support diet “diet palsy injury. injury injury” analíticos NewcastleOttawa Newcastle Ottawa Collaboration clínicos n=658 n658 n 658 (n=658 199 202 inclusão viés desenvolvidos beneficiaramse beneficiaram se oral prejudicadas disso Conclusões desnutrição pacientes (PC n=65 n65 65 (n=65 19 20 n=6 n6 6 (n=6 2 n= (n= (n

ABSTRACT Objective: To systematically review the literature in search of the most suitable and effective nutritional interventions and indications for the nutritional treatment of children and adolescents with cerebral palsy (CP). Data source: This review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The articles were selected from seven databases (Cochrane, Literatura Latino-Americana e do Caribe em Ciências da Saúde — Lilacs, Embase, United States National Library of Medicine — PubMed, Scientific Electronic Library Online — SciELO, Scopus, and Web of Science). Studies from a pediatric group (0 to 18 years old) diagnosed with CP were included and the search strategy included the descriptors: “children” OR “childhood” AND “nutritional therapy” OR “nutritional intervention” OR “nutrition” OR “nutritional support” OR “diet” AND “cerebral palsy” OR “cerebral injury”. Methodological quality was assessed using the checklist for cross-sectional analytical studies, the Newcastle-Ottawa scale or the Cochrane Collaboration tool for clinical trials. Data synthesis: Fifteen studies (n=658) published from 1990 to 2020 met the inclusion criteria. All of them had a low risk of bias. The data showed that children and adolescents with CP have worse nutritional status than those normally developed. Those who received hypercaloric and hyperprotein nutritional supplementation benefited from its use. Studies indicate that enteral nutrition should be considered when nutritional needs are not met by the oral diet, especially in cases where oral motor functions are impaired. In addition, there was a direct relationship between the consistency of food, the level of motor function and nutritional status. Conclusions: Children and adolescents with CP have a greater risk of malnutrition. The use of nutritional supplementation may help with weight gain. In addition, enteral nutrition and modification of food texture have been used to improve the nutritional status of this group. Objective CP. . (CP) source MetaAnalyses Meta Analyses PRISMA (PRISMA guidelines Cochrane, (Cochrane LatinoAmericana Latino Americana Lilacs Embase PubMed SciELO Scopus Science. Science Science) 0 ( 1 old descriptors “children childhood “childhood therapy intervention “nutrition support diet “diet injury. injury injury” crosssectional cross sectional NewcastleOttawa Newcastle Ottawa trials synthesis n=658 n658 n 658 (n=658 199 202 criteria bias developed impaired addition Conclusions malnutrition gain (CP n=65 n65 65 (n=65 19 20 n=6 n6 6 (n=6 2 n= (n= (n

ABSTRACT BACKGROUND: Few food frequency questionnaires (FFQ) have been validated for pregnant women, particularly those in small- and medium-sized cities in different regions of Brazil. OBJECTIVES: To validate and calibrate a semiquantitative FFQ for pregnant women. DESIGN AND SETTING: The study was validated with a sample of 50 pregnant women (≥ 18 years) enrolled in Brazilian prenatal services. METHODS: An FFQ and a 24-hour recall were used to evaluate dietary intake. Dietary variables were tested for normality and log-converted when asymmetrical. Pearson's Correlation Coefficient was used to validate the questionnaire. Linear regression was applied to extract calibration factors. All variables underlying the consumption analysis were adjusted for energy. RESULTS: The mean age of the pregnant women was 26 years ± 6.2 years; 58% were in their first trimester, and 30% were identified as overweight/obese. The Pearson correlation analysis results indicated that the FFQ overestimated energy and nutrient intake, whose coefficients ranged from −0.15 (monounsaturated fat) to 0.50 (carbohydrate). Adjusting for energy reduced the mean values of intake coefficients, which now ranged from −0.33 (sodium) to 0.96 (folate). The calibration analysis results indicated variation in the coefficients from −0.23 (sodium) to 1.00 (folate). Calibration produced satisfactory coefficients for the FFQ compared with the reference standard for energy, macronutrients, monounsaturated fat, cholesterol, vitamins B12/C, folate, sodium, iron, and calcium. CONCLUSIONS: After validating and calibrating tests, we observed that the FFQ was adequately accurate for assessing the food consumption of the pregnant women in this study. BACKGROUND (FFQ small mediumsized medium sized Brazil OBJECTIVES SETTING 5 ≥ ( 1 services METHODS 24hour hour 24 logconverted log converted asymmetrical Pearsons s questionnaire factors RESULTS 2 62 6 6. 58 trimester 30 overweightobese overweight obese overweight/obese 015 0 15 −0.1 fat 050 0.5 carbohydrate. carbohydrate . (carbohydrate) 033 33 −0.3 sodium (sodium 096 96 0.9 folate. folate (folate) 023 23 −0.2 100 00 1.0 macronutrients cholesterol B12C BC B12 C B B12/C iron calcium CONCLUSIONS tests 3 01 −0. 05 0. (carbohydrate 03 09 9 (folate 02 10 1. B1 −0 −

RESUMO Objetivo: Analisar a conformidade da comercialização dos produtos infantis incluídos na Norma Brasileira de Comercialização de Alimentos para Lactentes e Crianças de Primeira Infância, Bicos, Chupetas e Mamadeira (NBCAL) e de compostos lácteos em drogarias de Uberlândia/MG. Métodos: Estudo transversal realizado em 143 drogarias que vendiam produtos infantis: fórmulas infantis (FI) para lactentes, FI de seguimento para lactentes, mamadeiras, bicos, chupetas e protetores de mamilo; FI para crianças de primeira infância, alimentos de transição e alimentos à base de cereais, leites fluidos/em pó, leites modificados/similares de origem vegetal e composto lácteo. A localização das drogarias nos cinco setores geográficos foi realizada por geoprocessamento. Os dados coletados foram: tipos de promoção comercial irregular e tipo de administração da drogaria (rede/independente). As promoções comerciais irregulares foram expressas em frequências absoluta e relativa. Resultados: Verificamos a presença de promoção comercial irregular em 11,7% dos bicos, chupetas e mamadeiras, em 10,0% das FI lactentes/seguimento de lactentes, em 9,5% das FI para crianças de primeira infância, em 11,1% dos leites, em 25,0% de alimentos de transição e em 59,1% dos compostos lácteos. Nas drogarias de rede, a presença de promoção comercial irregular foi maior para compostos lácteos (81,8 vs. 28,6%, respectivamente) e, para leites, foi maior nas drogarias independentes (30,8 vs. 6,0%). Os setores central e leste apresentaram os maiores percentuais de promoção comercial irregular (26%). Conclusões: As violações à NBCAL ainda ocorrem nas drogarias, principalmente para os produtos destinados às crianças de primeira infância, e nas drogarias de rede. Objetivo Infância Bicos (NBCAL UberlândiaMG Uberlândia MG Uberlândia/MG Métodos 14 (FI lactentes mamadeiras bicos mamilo infância cereais fluidosem fluidos pó modificadossimilares modificados similares lácteo geoprocessamento rede/independente. redeindependente rede/independente . rede independente (rede/independente) relativa Resultados 117 11 7 11,7 100 10 0 10,0 lactentesseguimento 95 9 5 9,5 111 1 11,1 250 25 25,0 591 59 59,1 81,8 818 81 8 (81, vs 286 28 6 28,6% respectivamente 30,8 308 30 (30, 6,0%. 60 6,0% 6,0%) 26%. 26 26% (26%) Conclusões (rede/independente 11, 10, 9, 2 25, 59, 81, (81 28,6 30, 3 (30 6,0 (26% (8 28, (3 6, (26 ( (2

ABSTRACT Objective: To analyze the compliance with the commercialization of children's products included in the Brazilian Code of Marketing of Infant and Toddlers Food and Childcare-Related Products (NBCAL) in drugstores in Uberlândia/MG. Methods: A cross-sectional study was carried out in 143 drugstores that sold infant products: infant formula (IF), follow-up IF, nipples, teats, pacifiers and nipple shields; FI for young children, transition foods and cereal-based foods, fluid or powdered milk, modified/similar milks of plant origin and dairy compounds. The location of drugstores in the five geographic sectors was performed by geoprocessing. The data collected were: types of promotion and types of drugstore administration (drugstore chains/drugstores with independent administration). Irregular commercial promotion was expressed as absolute and relative frequencies. Results: Irregular commercial promotion was found in 11.7% of nipples, pacifiers and bottles, in 10.0% of IF and follow-up formula, in 9.5% of IF for young children, in 11.1% fluid or powdered milk, in 25.0% of transition foods and cereal-based foods and in 59.1% of dairy compounds. In commercial drugstore chains, the presence of promotion for dairy (81.8 vs. 28.6%, respectively) was higher than in drugstores with independent administration. The opposite ocurred for fluid or powdered milk, modified and similar milks of plant origin. The downtown and eastern sectors had the highest percentages of promotions (26%). Conclusions: NBCAL violations still occur in drugstores, mainly in the sale of young children's foods and in the commercial network drugstores. Objective childrens children s ChildcareRelated Childcare Related (NBCAL UberlândiaMG Uberlândia MG Uberlândia/MG Methods crosssectional cross sectional 14 , (IF) followup follow up nipples teats shields cerealbased cereal based milk modifiedsimilar compounds geoprocessing were chainsdrugstores chains . administration) frequencies Results 117 11 7 11.7 bottles 100 10 0 10.0 95 9 5 9.5 111 1 11.1 250 25 25.0 591 59 59.1 81.8 818 81 8 (81. vs 286 28 6 28.6% respectively 26%. 26 26% (26%) Conclusions (IF 11. 10. 9. 2 25. 59. 81. (81 28.6 (26% (8 28. (26 ( (2