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RESUMO: O estudo foi realizado em um ovino, fêmea, de três anos de idade, da raça santa inês, procedente de uma propriedade localizada do município de Santo Antônio de Tauá, oeste do Pará. O animal acometido tinha histórico de exoftalmia no olho esquerdo, secreção nasal e dificuldade respiratória há mais de três meses. Ao exame físico o animal apresentava baixo escore corporal, apatia, assimetria facial unilateral, moderada exoftalmia unilateral esquerda, dispneia mista e exsudação nasal serossanguinolenta profusa unilateral. À necropsia, foi observada grande massa nasal, predominantemente branco-amarelada com áreas vermelho enegrecidas, de superfície irregular, finamente granular, úmida e friável. A massa invadia desde a junção mucocutânea do nariz esquerdo até as coanas, se infiltrava pelos seios nasais frontais, placa cribiforme e alcançava as meninges e a porção frontal do cérebro. À microscopia da superfície do epitélio nasal notou-se severa destruição dos cornetos e dos epitélios, evidenciada por extensas áreas de necrose com muitos debris celulares, ulceração e infecção bacteriana secundária. No sistema nervoso central (SNC) havia meningite piogranulomatosa com acentuada congestão de vasos, focos de necrose e inflamação granulomatosa. O diagnóstico de rinite granulomatosa de origem micótica associada ao fungo Conidiobolus lamprauges foi baseado nos achados da imuno-histoquímica. RESUMO ovino fêmea idade inês Tauá Pará meses corporal apatia esquerda necropsia brancoamarelada branco amarelada enegrecidas irregular granular friável coanas frontais cérebro notouse notou epitélios celulares secundária SNC (SNC vasos imunohistoquímica. imunohistoquímica imuno histoquímica. histoquímica imuno-histoquímica

ABSTRACT: The study was conducted on a 3-year-old female Santa Inês sheep from a property located in the municipality of Santo Antônio de Tauá, west of Pará. The affected animal had a history of exophthalmos in the left eye, nasal discharge, and breathing difficulty for more than three months. On physical examination, the animal had a low body score, apathy, unilateral facial asymmetry, moderate unilateral left exophthalmos, mixed dyspnea and unilateral profuse serosanguinous nasal discharge. At necropsy, a large nasal mass was observed, predominantly yellowish-white with blackish-red areas, with an irregular, finely granular, moist, and friable surface. The mass invaded from the mucocutaneous junction of the left nostril to the choanae, infiltrated the frontal sinuses, the cribiform plate, and reached the meninges and the frontal portion of the brain. Microscopy of the surface of the nasal epithelium showed severe destruction of the turbinates and epithelia, evidenced by extensive areas of necrosis with a large amount of cellular debris, ulceration, and secondary bacterial infection. In the central nervous system there was pyogranulomatous meningitis with marked vessel congestion, as well as foci of necrosis and granulomatous inflammation. Immunohistochemistry showed intense staining of numerous intralesional hyphae for antibodies against Conidiobolus lamprauges. The diagnosis of granulomatous rhinitis of mycotic origin associated with the Conidiobolus lamprauges was based on epidemiological, clinical-pathological, and immunohistochemical data. ABSTRACT 3yearold yearold 3 year old Tauá Pará eye discharge months examination score apathy asymmetry necropsy observed yellowishwhite yellowish white blackishred blackish red irregular granular moist choanae sinuses plate brain epithelia debris ulceration infection congestion inflammation epidemiological clinicalpathological, clinicalpathological clinical pathological, pathological clinical-pathological data

https://doi.org/10.1590/0103-8478cr20240016

Mango (Mangifera indica) meal can partially replace corn meal in diets for piava (Megaleporinus obtusidens) Mangifera indica Megaleporinus obtusidens
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Marchão, Rafael Silva

; Copatti, Carlos Eduardo

; Rocha, Aline da Silva

; Costa, Thaisa Sales

; Silva, Rafael Carvalho da

; Pereira, Gilmar Amaro

; Rocha, David Ramos da

; Melo, José Fernando Bibiano

Ciência Rural

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2025, Volume 55 N. 4 elocation e20230670

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO: A produção de manga (Mangifera indica) está se expandindo em muitos países e seus resíduos tem o potencial de ser usado para a fabricação de dietas para peixes. Este estudo avaliou a substituição parcial de fubá de milho por farinha de manga (FM) em dietas para piava (Megaleporinus obtusidens) em termos de performance zootécnica, glicose do plasma, enzimas intestinais e análise microbiológica. Piavas (n = 160) foram distribuídas em um esquema completamente randomizado (quatro tratamentos e quatro repetições) e alimentadas por 45 dias com dietas contendo diferentes níveis de inclusão de FM (0, 33, 66 e 100%). Não houve nenhuma contaminação microbiológica (bolor, coliformes totais, Bacillus cereus e Salmonella sp.) na FM. Os fenóis totais e taninos totais foram maiores na dieta com FM (P < 0.05). Dietas com 100% de fubá de milho substituído por MM reduziu a performance de crescimento e aumento a taxa de conversão alimentar (TCA) e os níveis de glicose nos peixes (P < 0.05). De acordo com a análise de regressão de segunda ordem, o nível ideal de inclusão de FM na dieta estimado com base no ganho de peso e o TCA foi de 23,68 e 19,75%, respectivamente (P < 0.05). O aumento gradual dos níveis de FM substituindo fubá de milho na dieta reduziu a atividade das enzimas intestinais amilase, lipase e protease alcalina (P < 0.05). Em conclusão, recomendamos a substituição de 19,75-23,68% de fubá de milho por FM, que pode ser usada nas dietas de piava. RESUMO Mangifera indica (FM Megaleporinus obtusidens zootécnica plasma n 160 repetições 4 0, 0 (0 33 6 100%. 100 . 100%) bolor, bolor (bolor sp. sp P 0.05. 005 0.05 05 0.05) (TCA ordem 2368 23 68 23,6 1975 19 75 19,75% amilase conclusão 19,7523,68% 19752368 19,75 23,68% 19,75-23,68 16 ( 3 10 00 0.0 236 2 23, 197 1 7 7523 19,7523,68 1975236 19,7 19,75-23,6 0. 752 19,7523,6 197523 19, 19,75-23, 19,7523, 19752 19,75-23 19,7523 19,75-2 19,752 19,75-

ABSTRACT: Mango (Mangifera indica) production is expanding in many countries, and its discarded residues have the potential to be used in the manufacture of fish diets. This study evaluated replacing part of the corn meal (CM) with mango meal (MM) in diets for piava (Megaleporinus obtusidens) in terms of zootechnical performance, plasma glucose, and intestinal enzymes. Piavas (n = 160) were distributed in a completely randomized design (four treatments and four replications) and were fed for 45 days with diets containing different levels of MM inclusion (0, 33, 66, and 100%). There was no microbiological contamination (mold, total coliforms, Bacillus cereus, and Salmonellasp.) in MM. The MM diet had higher total phenols and total tannins (P < 0.05). Diets with 100% of the CM replaced by MM reduced the growth performance and increased the feed conversion ratio (FCR) and plasma glucose levels in piava (P < 0.05). According to the second-order regression analysis, the optimal level of MM inclusion in the diet estimated based on weight gain and FCR was 23.68 and 19.75%, respectively (P < 0.05). The gradual increase in MM levels replacing CM in the diet reduced the activity of the intestinal enzymes amylase, lipase, and alkaline protease (P < 0.05). In conclusion, we recommended replacing 19.75-23.68% of CM with MM, which can be used in piava diets. ABSTRACT Mangifera indica countries (CM (MM Megaleporinus obtusidens n 160 replications 4 0, 0 (0 33 66 100%. 100 . 100%) mold, mold (mold coliforms cereus Salmonellasp. Salmonellasp P 0.05. 005 0.05 05 0.05) (FCR secondorder second order analysis 2368 23 68 23.6 1975 19 75 19.75% amylase lipase conclusion 19.7523.68% 19752368 19.75 23.68% 19.75-23.68 16 ( 3 6 10 00 0.0 236 2 23. 197 1 7 7523 19.7523.68 1975236 19.7 19.75-23.6 0. 752 19.7523.6 197523 19. 19.75-23. 19.7523. 19752 19.75-23 19.7523 19.75-2 19.752 19.75-

https://doi.org/10.1590/0103-8478cr20230670

Safflower seeds development: physical changes and the role of gibberellic acid, light, and temperature development acid light
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da Silva, Bruna Neves Pereira

; Masetto, Tathiana Elisa

; Zanzi, José Vinicius dos Santos

; Pereira, Gislaine da Silva

; de Souza, Luiz Carlos Ferreira

Scientia Agricola

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2025, Volume 82 elocation e20230162

Abstract: En | Text: En | PDF: En

ABSTRACT Safflower is a crop with seeds containing high amounts of oleic and linoleic acids, which have applications in cosmetics, food, feed, and pharmaceutical industries. Safflower seeds are generally reported to undergo after-ripening and to have physiological dormancy. This study comprehensively analyzed the physical changes and the induction of dormancy and germinability in developing seeds to determine whether the safflower population is adequately developed during seed dispersal. From the 80th day after flowering (DAF), seeds were collected separately from plants on a weekly basis until 131 DAF, resulting in seven sampling dates. The changes in length, diameter, thickness, water content, and fresh and dry weight during seed development were measured. Simultaneously, the effects of dark and light, temperature, and gibberellic acid (GA3) (0, 50, and 100 µM) on seed germination, dormancy and germination characteristics of safflower seeds were investigated. The seeds ceased to increase in length, width and thickness, reaching a mature appearance at 131 DAF, with a dry mass per seed of 0.0443 g. The water content decreased between 117 and 124 DAF, indicating an obvious process of desiccation during the final stage of seed maturation. Germination capacity is acquired at 117 DAF, as evidenced by an increase in germination and a reduction in dormant seeds, particularly at low temperatures (10°C) and with GA3 supplementation. At 131 DAF, seeds exhibited 7.9 % water content, and there was an increase in seed germination and a decrease in seed dormancy status, regardless of GA3 supplementation and temperature. acids cosmetics food feed industries afterripening ripening dispersal th DAF , (DAF) 13 dates length diameter thickness measured Simultaneously light temperature GA (GA3 0, 0 (0 50 10 µM investigated 00443 0443 0.044 g 11 12 maturation 10°C 10C C (10°C 79 7 9 7. status (DAF 1 (GA ( 5 0044 044 0.04 004 04 0.0 00 0.

https://doi.org/10.1590/1678-992x-2023-0162

Educação popular no SUS: desafios atuais no olhar do Observatório de Educação Popular em Saúde e Realidade Brasileira
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Cruz, Pedro José Santos Carneiro

; Brito, Pedro Nascimento Araujo

; Santana, Elôysa Laura Pereira de

; Silva, José Carlos da

; Barbosa, Daniella de Souza

; Moraes, Odara Alves

Ciência & Saúde Coletiva

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jun 2024, Volume 29 N. 6 elocation e17132023

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Este trabalho se propõe a trazer reflexões e apontamentos para o fortalecimento de políticas públicas estruturantes no Brasil, com foco na Educação Popular em Saúde no Sistema Único de Saúde (SUS), a partir das perspectivas construídas no Observatório de Educação Popular em Saúde e Realidade Brasileira. O Observatório é um espaço profícuo para o compartilhamento de interpretações e experiências de profissionais de saúde e educadores populares sobre a realidade local e realidade brasileira, a partir da ótica da Educação Popular em Saúde. De forma dialógica e participativa, ao longo de seus 2 anos de atividade, o Observatório foi capaz de reunir interpretações sintéticas da Educação Popular em Saúde para as crises que atravessam a história recente do país. De maneira panorâmica, as falas compartilhadas apontam desafios para valorização da abordagem humana na promoção da saúde, com a inclusão e o respeito aos saberes e práticas sociais locais e comunitárias. Além disso, destaca-se a importância da participação social na construção de processos sociais participativos na saúde pública, visando à autonomia do cidadão e à ampliação da dinâmica democrática no Estado brasileiro e em seus equipamentos sociais.

Abstract This paper aims to bring reflections and notes for strengthening Brazilian structuring public policies, focusing on Popular Health Education in the Unified Health System (SUS) from the perspectives built in the Observatory of Popular Health Education and the Brazilian Reality. The Observatory is a valuable space for sharing health professionals’ and popular educators’ interpretations and experiences about local and Brazilian realities from the perspective of Popular Health Education. During its two years of activity, the Observatory has gathered summary interpretations of Popular Health Education for the crises that traverse the country’s recent history in a dialogical and participatory way. In a panoramic view, the shared statements point to challenges for valuing the human approach to health promotion, including respecting local and community knowledge and social practices. Moreover, we underscore the importance of social participation in constructing participatory social processes in public health toward citizen autonomy and expanded democratic dynamics in the Brazilian State and its social equipment.

https://doi.org/10.1590/1413-81232024296.17132023

O que se tem discutido sobre Educação Popular em Saúde nos últimos anos: uma revisão narrativa da literatura
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Brito, Pedro Nascimento Araujo

; Santana, Elôysa Laura Pereira de

; Moraes, Odara Alves

; Silva, José Carlos da

; Cruz, Pedro José Santos Carneiro

Ciência & Saúde Coletiva

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jun 2024, Volume 29 N. 6 elocation e12542023

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Esta revisão narrativa tem por objetivo analisar a literatura no âmbito da Saúde Coletiva no intento de reconhecer o que se tem discutido em Educação Popular em Saúde (EPS) entre 2019 e 2022. Após busca, 59 artigos foram selecionados, analisados criticamente e separados em seis categorias-síntese: as práticas de educação popular como promotoras de uma visão participativa da saúde; educação popular e a valorização dos saberes e práticas da cultura popular local; a educação popular em saúde como estratégia de apoio à reconstrução social ante aos retrocessos nas políticas públicas; a importância da articulação nacional em educação popular como resposta à sua desvalorização; a educação popular como projeto libertador pensando a formação democrática e luta contra violências institucionais e estruturais; educação popular no processo de formação universitária em saúde. Pôde-se obter importantes resultados que elucidam a importância da EPS no contexto do Sistema Único de Saúde e na formação acadêmica de profissionais da saúde, favorecendo o respeito aos saberes ancestrais e a horizontalidade do cuidado. Ainda, reafirma-se a necessidade de articulação nacional e dialogada com os movimentos populares para o avanço de uma agenda emancipadora e dignificante da saúde no Brasil.

Abstract This narrative review aims to analyze the literature on Collective Health to recognize what has been discussed in Popular Health Education (PHE) from 2019 to 2022. Fifty-nine articles were selected, critically analyzed, and separated into six summary categories: popular education practices as promoters of a participatory vision of health; popular education and the valorization of local popular culture knowledge and practices; popular health education as a strategy to support social reconstruction in the face of setbacks in public policies; the importance of national articulation in popular education as a response to its devaluation; popular education as a liberating project thinking about the democratic formation and the fight against institutional and structural violence; popular education in the university health training process. We achieved significant results that elucidate the importance of PHE within the Unified Health System and the academic education of health professionals, fostering respect for ancestral knowledge and care horizontality. We also reaffirm the need for national articulation and dialogue with grassroots movements to advance Brazil’s emancipatory and dignifying health agenda.

https://doi.org/10.1590/1413-81232024296.12542023

Clinical Characteristics of Genuine Acute Autoimmune Hepatitis
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Oliveira, Elze Maria Gomes

; Amaral, Ana Cristina de Castro

; Oliveira, Patricia Marinho Costa

; Lanzoni, Valéria Pereira

; Perez, Renata Mello

; Narciso-Schiavon, Janaína Luz

; Whale, Raul Carlos

; Carvalho-Filho, Roberto José

; Silva, Antonio Eduardo Benedito

; Ferraz, Maria Lucia Cardoso Gomes

GE-Portuguese Journal of Gastroenterology

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jun 2024, Volume 31 N. 3 Pages 21 - 29

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract Introduction: Autoimmune hepatitis (AIH) has a spectrum of symptoms ranging from asymptomatic disease to acute severe hepatitis, chronic hepatitis, and decompensated cirrhosis. The acute presentation is not rare and could represent genuine acute AIH (GAAIH) or acute exacerbation of chronic autoimmune hepatitis. We aimed to identify the prevalence, clinical features, and prognostic factors associated with GAAIH and compare these cases with acute exacerbation of chronic AIH. Methods: This cross-sectional observational study evaluated patients with acute AIH presentation, deﬁned as total bilirubin >5 times the upper limit of normality (xULN) and/or alanine aminotransferase >10 xULN, and no prior history of liver disease. Histology ﬁndings of acute disease deﬁned GAAIH. Bivariate analyses were performed to identify factors associated with the GAAIH, when compared with acute exacerbation of chronic AIH. Results: Seventy-two patients with acute presentation of AIH were included and six (8.3%) of them presented GAAIH. Comparative analysis between patients with GAAIH and patients with acute exacerbation of chronic AIH revealed that prothrombin activity (96% [74-100] vs. 61% [10-100]; p = 0.003) and albumin levels (3.9 ± 0.2 g/dL vs. 3.4 ± 0.5 g/dL; p < 0.001) were higher in patients with GAAIH. The International Autoimmune Hepatitis Group score was higher in patients with acute exacerbation of chronic AIH (18.5 [8-23] vs. 16.5 [15-17]; p = 0.010). Compared to 15.2% of acute exacerbation of chronic AIH, complete therapeutic response to treatment was achieved in 67.7% of cases with GAAIH (p = 0.018). Conclusions: GAAIH was rare (8.3%), and patients with this presentation exhibited more preserved liver function tests, suggesting that most cases presenting with loss of function are acute exacerbation of chronic AIH. Additionally, patients with GAAIH had a better complete therapeutic response, suggesting a more preserved liver function at presentation, and early diagnosis has a positive therapeutic implication.

Resumo Introdução: A hepatite autoimune (HAI) apresenta um espectro de sintomas que varia de doença assintomática a hepatite aguda grave, hepatite crónica e cirrose descompensada. A apresentação aguda não é rara e pode representar hepatite autoimune aguda genuína (HAIAG) ou exacerbação aguda de hepatite autoimune crónica (EAHAIC). O nosso objetivo foi identiﬁcar a prevalência, caraterísticas clínicas e fatores prognósticos associados à HAIAG, e comparar esses casos com EAHAIC. Métodos: Estudo observacional, transversal, incluindo doentes com apresentação aguda de HAI, deﬁnida como bilirrubina total > 5 vezes o limite superior da normalidade (xLSN) e/ou ALT > 10 xLSN, e sem história prévia de doença hepática. HAIAG foi deﬁnida pela presença de achados histológicos de doença aguda. Análises bivariadas foram realizadas para identiﬁcar fatores associados à HAIAG, quando comparado com o EAHAIC. Resultados: Foram incluídos setenta e dois doentes com apresentação agu-da de HAI, dos quais seis (8.3%) com HAIAG. A análise comparativa entre doentes com HAIAG e doentes com EAHAIC mostrou que a atividade de protrombina (96%(74-100) versus 61% (10-100; p=0.003) e os níveis de albumina (3,9 ± 0,2 g/dL vs. 3,4 ± 0,5 g/dL; p < 0,001) foram signiﬁcativamente mais elevados em pacientes com HAIAG. O score do Grupo Internacional de Hepatite Autoimune foi mais elevado em doentes com EAHAIC (18.5 (8-23) versus 16.5 (15-17); p=0.010). A resposta terapêutica completa ao tratamento foi alcançada em 66.7% dos casos de HAIAG (vs. 15,2% na EAHAIC, p=0,018). Conclusões: A HAIAG é rara (8.3%), e os doentes com esta apresentação mostraram testes de função hepática mais preservados, sugerindo que a maioria dos casos com perda de função são EAHAIC. Além disso, os doentes com HAIAG tiveram maior taxa de resposta terapêutica completa, sugerindo que uma função hepática mais preservada na apresentação e o diagnóstico precoce tem uma implicação terapêutica positiva.

https://doi.org/10.1159/000531018

Efeito do monitoramento telefônico de Intervenções Breves para uso de álcool entre gestantes: ensaio clínico randomizado
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Moura, Adaene Alves Machado de

; Pillon, Sandra Cristina

; Silva Júnior, Fernando José Guedes da

; Zerbetto, Sônia Regina

; Pegoraro, Natália Priolli Jora

; Cruz, Jefferson Pereira Maciel da

; Aliane, Poliana Patrício

; Gonçalves, Angélica Martins de Souza

Revista Portuguesa de Enfermagem de Saúde Mental

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jun 2024, N. 31 Pages 38 - 52

Abstract: Es En Pt | Text: Es En Pt | PDF: Es | PDF: En | PDF: Pt

Resumen Objetivo: comprobar si el seguimiento telefónico agrega efecto a la aplicación de Intervenciones Breves para el uso de alcohol entre las mujeres embarazadas. Metodología: se trata de un ensayo clínico controlado y aleatorizado, abierto, paralelo, de dos brazos. Los datos fueron recolectados en la atención primaria de salud en São Carlos y el Centro de Referencia para la Salud de la Mujer en Ibaté (São Paulo, Brasil). Se realizó un seguimiento de las mujeres embarazadas que consumieron cualquier cantidad de alcohol durante el embarazo. Posteriormente, fueron distribuidos aleatoriamente en dos grupos. El grupo de control recibió solo una breve intervención; el grupo experimental recibió una intervención breve y fue monitoreado semanalmente por teléfono durante dos semanas después de la intervención. Se utilizó un programa estadístico para realizar estadísticas descriptivas e inferenciales (Test de Wilcoxon). Resultados: Hubo una reducción en el consumo en ambos grupos. Sin embargo, solo en el grupo experimental en el que se implementó la intervención con seguimiento, hubo abstinencia en todo el grupo (AUDIT-C: p-valor=0,011; T-ACE: p-valor=0,010). Conclusiones: Las intervenciones breves asociadas al seguimiento telefónico durante el embarazo demostraron ser efectivas para detener el consumo de alcohol. El seguimiento continuo después de intervenciones breves mejora las tasas de abstinencia de alcohol. Registro Brasileño de Ensayos Clínicos: RBR-4y4k7w.

Abstract Objective: to test whether telephone monitoring adds effect to the application of Brief Interventions for alcohol use among pregnant women. Methodology: this is a controlled and randomized clinical trial, open, parallel, with two arms. Data were collected in primary health care in São Carlos and Reference Center for Women's Health in Ibaté (São Paulo, Brazil). Pregnant women who consumed any amount of alcohol during pregnancy were tracked. Afterwards, they were randomly allocated into two groups. The control group received only a brief intervention; the experimental group received a brief intervention and were monitored weekly by telephone for two weeks after the intervention. A statistical program was used to perform descriptive and inferential statistics (Wilcoxon Test). Results: There was a reduction in consumption in both groups. However, only in the experimental group in which the intervention with monitoring was implemented, there was abstinence in the entire group (AUDIT-C: p-value=0.011; T-ACE: p-value=0.010). Conclusions: Brief interventions associated with telephone monitoring during pregnancy proved to be effective in stopping alcohol consumption. Continuous monitoring after brief interventions improves alcohol abstinence rates. Brazilian Registry of Clinical Trials: RBR-4y4k7w.

Resumo Objetivo: testar se o monitoramento por telefone acrescenta efeito à aplicação de Intervenções Breves para o uso de álcool entre gestantes. Metodologia: trata-se de ensaio clínico controlado e randomizado, aberto, paralelo, com dois braços. Os dados foram coletados na atenção primária à saúde de São Carlos e Centro de Referência de Saúde da Mulher em Ibaté (São Paulo, Brasil). Foram rastreadas gestantes que consumiram qualquer quantidade de álcool na gestação. Após, foram alocadas aleatoriamente em dois grupos. O grupo controle recebeu apenas uma intervenção breve; o grupo experimental recebeu uma intervenção breve e foi monitorado semanalmente por telefone nas duas semanas posteriores à intervenção. Utilizou-se programa estatístico para realização de estatísticas descritivas e inferencial (Teste de Wilcoxon). Resultados: Houve redução do consumo nos dois grupos. Porém, apenas no grupo experimental em que foi implementado intervenção com monitoramento, houve abstinência de todo o grupo (AUDIT-C: p-valor=0,011; T-ACE: p-valor=0,010). Conclusões: Intervenções breves associadas a monitoramento telefônico durante a gestação se mostraram efetivas para a cessação do consumo de álcool. O monitoramento contínuo após intervenções breves melhora as taxas de abstinência de álcool. Registro Brasileiro de Ensaios Clínicos: RBR-4y4k7w.

https://doi.org/10.19131/rpesm.379

Educação popular no SUS: desafios atuais no olhar do Observatório de Educação Popular em Saúde e Realidade Brasileira SUS
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Cruz, Pedro José Santos Carneiro

; Brito, Pedro Nascimento Araujo

; Santana, Elôysa Laura Pereira de

; Silva, José Carlos da

; Barbosa, Daniella de Souza

; Moraes, Odara Alves

Ciência & Saúde Coletiva

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jun 2024, Volume 29 N. 6 elocation e17132023

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.1590/1413-81232024296.17132023

O que se tem discutido sobre Educação Popular em Saúde nos últimos anos: uma revisão narrativa da literatura anos
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Brito, Pedro Nascimento Araujo

; Santana, Elôysa Laura Pereira de

; Moraes, Odara Alves

; Silva, José Carlos da

; Cruz, Pedro José Santos Carneiro

Ciência & Saúde Coletiva

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jun 2024, Volume 29 N. 6 elocation e12542023

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.1590/1413-81232024296.12542023

10.

[SciELO Preprints] - Guidelines on the Diagnosis and Treatment of Hypertrophic Cardiomyopathy – 2024
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Fernandes, Fabio Simões, Marcus V. Correia, Edileide de Barros Marcondes-Braga, Fabiana G. Coelho-Filho, Otavio Rizzi Mesquita, Cláudio Tinoco Mathias-Junior, Wilson Rochitte, Carlos Eduardo Ramires, Felix José Alvarez Alves, Silvia Marinho Martins Montera, Marcelo Westerlund Lopes, Renato Delascio Oliveira-Junior, Mucio Tavares Scolari, Fernando L. Avila, Walkiria Samuel Canesin, Manoel Fernandes Bacal, Fernando Bocchi, Edimar Alcides Moura, Lídia Ana Zytynski Saad, Eduardo Benchimol Scanavacca, Mauricio I. Valdigem, Bruno Pereira Cano , Manuel Nicolas Abizaid , Alexandre Ribeiro, Henrique Barbosa Lemos-Neto, Pedro Alves Ribeiro, Gustavo Calado de Aguiar Jatene, Fabio Biscegli Dias, Ricardo Ribeiro Beck-da-Silva, Luis Rohde, Luis Eduardo P. Bittencourt, Marcelo Imbroinise Pereira, Alexandre Krieger, José Eduardo Villacorta, Humberto Martins, Wolney de Andrade Figueiredo-Neto, José Albuquerque de Cardoso , Juliano Novaes Pastore, Carlos Alberto Jatene, Ieda Biscegli Tanaka, Ana Cristina Sayuri Hotta, Viviane Tiemi Romano, Minna Moreira Dias Albuquerque, Denilson Campos de Mourilhe-Rocha, Ricardo Hajjar, Ludhmila Abrahão Brito, Fabio Sandoli de Caramelli , Bruno Calderaro, Daniela Farsky, Pedro Silvio Colafranceschi , Alexandre Siciliano Pinto, Ibraim Masciarelli Vieira , Marcelo Luiz Campos Danzmann, Luiz Claudio Barberato , Silvio Henrique Mady, Charles Martinelli-Filho, Martino Torbey , Ana Flavia Malheiros Schwartzmann, Pedro Vellosa Macedo, Ariane Vieira Scarlatelli Ferreira , Silvia Moreira Ayub Schmidt, Andre Melo , Marcelo Dantas Tavares de Lima-Filho, Moysés Oliveira Sposito, Andrei C. Brito, Flavio de Souza Biolo, Andreia Madrini-Junior, Vagner Rizk, Stéphanie Itala Mesquita, Evandro Tinoco

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Publication date: 2024-04-08

Abstract: Pt Es En

A cardiomiopatia hipertrófica (CMH) é uma forma de doença do músculo cardíaco de causa genética, caracterizada pela hipertrofia das paredes ventriculares. O diagnóstico requer detecção por métodos de imagem (Ecocardiograma ou Ressonância Magnética Cardíaca) de qualquer segmento da parede do ventrículo esquerdo com espessura > 15 mm, sem outra causa provável. A análise genética permite identificar mutações de genes codificantes de diferentes estruturas do sarcômero responsáveis pelo desenvolvimento da CMH em cerca de 60% dos casos, permitindo o rastreio de familiares e aconselhamento genético, como parte importante do manejo dos pacientes e familiares. Vários conceitos sobre a CMH foram recentemente revistos, incluindo sua prevalência de 1 em 250 indivíduos, não sendo, portanto, uma doença rara, mas subdiagnosticada. A vasta maioria dos pacientes é assintomática. Naqueles sintomáticos, a obstrução do trato de saída do ventrículo esquerdo (OTSVE) é o principal distúrbio responsável pelos sintomas, devendo-se investigar a sua presença em todos os casos. Naqueles em que o ecocardiograma em repouso ou com Manobra de Valsalva não detecta gradiente intraventricular significativo (> 30 mmHg), devem ser submetidos à ecocardiografia com esforço físico para detecção da OTSVE.   Pacientes com sintomas limitantes e grave OTSVE, refratários ao uso de betabloqueadores e verapamil, devem receber terapias de redução septal ou uso de novas drogas inibidoras da miosina cardíaca. Por fim, os pacientes adequadamente identificados com risco aumentado de morta súbita podem receber medida profilática com implante de cardiodesfibrilador implantável (CDI).

La miocardiopatía hipertrófica (MCH) es una forma de enfermedad cardíaca de origen genético, caracterizada por el engrosamiento de las paredes ventriculares. El diagnóstico requiere la detección mediante métodos de imagen (Ecocardiograma o Resonancia Magnética Cardíaca) que muestren algún segmento de la pared ventricular izquierda con un grosor > 15 mm, sin otra causa probable. El análisis genético permite identificar mutaciones en genes que codifican diferentes estructuras del sarcómero responsables del desarrollo de la MCH en aproximadamente el 60% de los casos, lo que permite el tamizaje de familiares y el asesoramiento genético, como parte importante del manejo de pacientes y familiares. Varios conceptos sobre la MCH han sido revisados recientemente, incluida su prevalencia de 1 entre 250 individuos, por lo tanto, no es una enfermedad rara, sino subdiagnosticada. La gran mayoría de los pacientes son asintomáticos. En los casos sintomáticos, la obstrucción del tracto de salida ventricular izquierdo (TSVI) es el trastorno principal responsable de los síntomas, y su presencia debe investigarse en todos los casos. En aquellos en los que el ecocardiograma en reposo o la maniobra de Valsalva no detecta un gradiente intraventricular significativo (> 30 mmHg), deben someterse a ecocardiografía de esfuerzo para detectar la obstrucción del TSVI. Los pacientes con síntomas limitantes y obstrucción grave del TSVI, refractarios al uso de betabloqueantes y verapamilo, deben recibir terapias de reducción septal o usar nuevos medicamentos inhibidores de la miosina cardíaca. Finalmente, los pacientes adecuadamente identificados con un riesgo aumentado de muerte súbita pueden recibir medidas profilácticas con el implante de un cardioversor-desfibrilador implantable (CDI).

Hypertrophic cardiomyopathy (HCM) is a form of genetically caused heart muscle disease, characterized by the thickening of the ventricular walls. Diagnosis requires detection through imaging methods (Echocardiogram or Cardiac Magnetic Resonance) showing any segment of the left ventricular wall with a thickness > 15 mm, without any other probable cause. Genetic analysis allows the identification of mutations in genes encoding different structures of the sarcomere responsible for the development of HCM in about 60% of cases, enabling screening of family members and genetic counseling, as an important part of patient and family management. Several concepts about HCM have recently been reviewed, including its prevalence of 1 in 250 individuals, hence not a rare but rather underdiagnosed disease. The vast majority of patients are asymptomatic. In symptomatic cases, obstruction of the left ventricular outflow tract (LVOT) is the primary disorder responsible for symptoms, and its presence should be investigated in all cases. In those where resting echocardiogram or Valsalva maneuver does not detect significant intraventricular gradient (> 30 mmHg), they should undergo stress echocardiography to detect LVOT obstruction. Patients with limiting symptoms and severe LVOT obstruction, refractory to beta-blockers and verapamil, should receive septal reduction therapies or use new drugs inhibiting cardiac myosin. Finally, appropriately identified patients at increased risk of sudden death may receive prophylactic measure with implantable cardioverter-defibrillator (ICD) implantation.

https://doi.org/10.1590/SciELOPreprints.8394

11.

A brief history of development theory. From Schumpeter and Prebisch to new developmentalism theory
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BRESSER-PEREIRA, LUIZ CARLOS

; OREIRO, JOSÉ LUIS

Brazilian Journal of Political Economy

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jan 2024, Volume 44 N. 1 Pages 5 - 28

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO O desenvolvimentismo clássico é uma teoria econômica heterodoxa que mostrou que os países precisam de intervenção moderada do Estado na economia para se industrializar. Os países latino-americanos adotaram essa política industrial a partir da década de 1950 e tiveram altas taxas de crescimento. Mas o argumento da indústria nascente perde validade com o tempo. Na década de 1980, sob a pressão do Norte, os países latino-americanos adotaram as reformas neoliberais e estão quase estagnados desde então. O novo desenvolvimentismo surgiu nos anos 2000, fez a crítica da economia convencional, formulou uma macroeconomia do desenvolvimento baseada nos cinco preços macroeconômicos, desenvolveu um argumento contraintuitivo contra a política de crescimento com endividamento e poupança externa e a retomada de tarifas de importação para neutralizar a doença holandesa. industrializar latinoamericanos latino americanos 195 tempo 1980 Norte então 2000 convencional macroeconômicos holandesa 19 198 200 1 20 2

ABSTRACT Classical developmentalism was heterodox economics that showed countries require a moderate intervention of the state in the economy to industrialize and catch up. Growth depends on investments and on a satisfying expected rate of profit, which import tariffs legitimized by the infant industry argument assure. Latin American countries adopted this industrial policy from the 1950s and experienced high growth rates. But the infant argument loses validity with time. In the 1980s, under the pressure of the Global North, Latin American countries adopted the neoliberal reforms, and are quasi-stagnant since then. New developmentalism emerged in the 2000s, made the critique of conventional economics, proposed a new growth strategy focused on a competitive exchange rate, and legitimized the use of import tariffs with the Dutch disease argument. up profit assure s rates time 1980s North reforms quasistagnant quasi stagnant then 2000s

https://doi.org/10.1590/0101-31572024-3604

12.

Diretrizes Brasileiras de Medidas da Pressão Arterial Dentro e Fora do Consultório – 2023 202 20 2
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Feitosa, Audes Diogenes de Magalhães

; Barroso, Weimar Kunz Sebba

; Mion Junior, Decio

; Nobre, Fernando

; Mota-Gomes, Marco Antonio

; Jardim, Paulo Cesar Brandão Veiga

; Amodeo, Celso

; Oliveira, Adriana Camargo

; Alessi, Alexandre

; Sousa, Ana Luiza Lima

; Brandão, Andréa Araujo

; Pio-Abreu, Andrea

; Sposito, Andrei C.

; Pierin, Angela Maria Geraldo

; Paiva, Annelise Machado Gomes de

; Spinelli, Antonio Carlos de Souza

; Machado, Carlos Alberto

; Poli-de-Figueiredo, Carlos Eduardo

; Rodrigues, Cibele Isaac Saad

; Forjaz, Claudia Lucia de Moraes

; Sampaio, Diogo Pereira Santos

; Barbosa, Eduardo Costa Duarte

; Freitas, Elizabete Viana de

; Cestario, Elizabeth do Espirito Santo

; Muxfeldt, Elizabeth Silaid

; Lima Júnior, Emilton

; Campana, Erika Maria Gonçalves

; Feitosa, Fabiana Gomes Aragão Magalhães

; Consolim-Colombo, Fernanda Marciano

; Almeida, Fernando Antônio de

; Silva, Giovanio Vieira da

; Moreno Júnior, Heitor

; Finimundi, Helius Carlos

; Guimarães, Isabel Cristina Britto

; Gemelli, João Roberto

; Barreto-Filho, José Augusto Soares

; Vilela-Martin, José Fernando

; Ribeiro, José Marcio

; Yugar-Toledo, Juan Carlos

; Magalhães, Lucélia Batista Neves Cunha

; Drager, Luciano F.

; Bortolotto, Luiz Aparecido

; Alves, Marco Antonio de Melo

; Malachias, Marcus Vinícius Bolívar

; Neves, Mario Fritsch Toros

; Santos, Mayara Cedrim

; Dinamarco, Nelson

; Moreira Filho, Osni

; Passarelli Júnior, Oswaldo

; Vitorino, Priscila Valverde de Oliveira

; Miranda, Roberto Dischinger

; Bezerra, Rodrigo

; Pedrosa, Rodrigo Pinto

; Paula, Rogerio Baumgratz de

; Okawa, Rogério Toshiro Passos

; Póvoa, Rui Manuel dos Santos

; Fuchs, Sandra C.

; Lima, Sandro Gonçalves de

; Inuzuka, Sayuri

; Ferreira-Filho, Sebastião Rodrigues

; Fillho, Silvio Hock de Paffer

; Jardim, Thiago de Souza Veiga

; Guimarães Neto, Vanildo da Silva

; Koch, Vera Hermina Kalika

; Gusmão, Waléria Dantas Pereira

; Oigman, Wille

; Nadruz Junior, Wilson

Arquivos Brasileiros de Cardiologia

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2024, Volume 121 N. 4 elocation e20240113

Abstract: Pt | Text: Pt | PDF: Pt

https://doi.org/10.36660/abc.20240113

13.

Evaluation of Meibomian gland dysfunction using meibography in patients with xeroderma pigmentosum
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Marcos, Allexya Affonso Antunes

; Freitas, Denise

; Hazarbassanov, Rossen Mihaylov

; Fernandes, Arthur Gustavo

; Castro, Ligia Pereira

; Melo, Danilo Batista Vieira de

; Menck, Carlos F. Martins

; Morales, Melina Correia

; Gomes, José Álvaro Pereira

; Belfort Neto, Rubens

; Singh, Arun D.

Arquivos Brasileiros de Oftalmologia

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2024, Volume 87 N. 2 elocation e2022-0319

Abstract: En | Text: En | PDF: En

ABSTRACT Purpose: To assess Meibomian gland dysfunction using meibography in patients with xeroderma pigmentosum and correlate with ocular surface changes. Methods: This cross-sectional study evaluated patients with xeroderma pigmentosum. All patients underwent a comprehensive and standardized interview. The best-corrected visual acuity of each eye was determined. Detailed ophthalmic examination was conducted, including biomicroscopy examination of the ocular surface, Schirmer test type I, and meibography, and fundus examination was also performed when possible. Meibomian gland dysfunction was assessed by non-contact meibography using Oculus Keratograph® 5M (OCULUS Inc., Arlington, WA, USA). Saliva samples were collected using the Oragene DNA Self-collection kit (DNA Genotek Inc., Ottawa, Canada), and DNA was extracted as recommended by the manufacturer. Factors associated with abnormal meiboscores were assessed using generalized estimating equation models. Results: A total of 42 participants were enrolled, and 27 patients underwent meibography. The meiboscore was abnormal in the upper eyelid in 8 (29.6%) patients and in the lower eyelid in 17 (62.9%). The likelihood of having abnormal meiboscores in the lower eyelid was 16.3 times greater than that in the upper eyelid. In the final multivariate model, age (p=0.001), mutation profile (p=0.006), and presence of ocular surface malignant tumor (OSMT) (p=0.014) remained significant for abnormal meiboscores. For a 1-year increase in age, the likelihood of abnormal meiboscores increased by 12%. Eyes with OSMT were 58.8 times more likely to have abnormal meiboscores than eyes without ocular surface malignant tumor. Conclusion: In the final model, age, xeroderma pigmentosum profile, previous cancer, and clinical alterations on the eyelid correlated with a meiboscore of ≥2. Meibomian gland dysfunction was common in patients with xeroderma pigmentosum, mainly in the lower eyelid. The severity of Meibomian gland dysfunction increases with age and is associated with severe eyelid changes. Purpose changes Methods crosssectional cross sectional interview bestcorrected best corrected determined conducted I possible noncontact non contact Keratograph M OCULUS Inc Inc. Arlington WA USA. USA . USA) Selfcollection Self collection Ottawa Canada, Canada , Canada) manufacturer models Results 4 enrolled 2 29.6% 296 29 6 (29.6% 1 62.9%. 629 62.9% 62 9 (62.9%) 163 16 3 16. model p=0.001, p0001 p p=0.001 0 001 (p=0.001) p=0.006, p0006 p=0.006 006 (p=0.006) (OSMT p=0.014 p0014 014 (p=0.014 1year year 12 12% 588 58 58. Conclusion cancer ≥2 29.6 (29.6 62.9 (62.9% p000 p=0.00 00 (p=0.001 (p=0.006 p=0.01 p001 01 (p=0.01 5 ≥ 29. (29. 62. (62.9 p00 p=0.0 (p=0.00 (p=0.0 (29 (62. p0 p=0. (p=0. (2 (62 p=0 (p=0 ( (6 p= (p= (p

https://doi.org/10.5935/0004-2749.2022-0319

14.

Estimation of factors related to the fertilization of banana plants selected in a fractional factorial scheme
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Campos, Matheus Pena

; Pio, Leila Aparecida Salles

; Rufini, José Carlos Moraes

; Bueno Filho, Júlio Sílvio de Sousa

; Ramos, Martha Cristina Pereira

; Costa, Ana Claudia

Revista Ceres

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2024, Volume 71 elocation e71010

Abstract: En | Text: En | PDF: En

ABSTRACT The objective of this study was to (i) use a combination of a definitive screening design (DSD) and a complete 33 factorial design to estimate the effects of four fertilizer supplements (factors) screened in the 1st planting cycle of Prata Gorutuba banana trees and (ii) determine whether combinations of these four factors can be identified for a future test. A DSD was combined with a complete 33 factorial scheme composed of three factors with three levels (application doses) each and three extra repetitions of the central level (commercial dose), totaling 30 experimental plots (27 + 3). The experimental area was divided into six blocks in a randomized block design (RBD) with 5 experimental plots each. The four selected factors included three soil conditioning products and a biostimulant based on seaweed extract. Experimental efficiency was maintained by performing a single trial with only 35.71% of the number of total plots used in the previous screening experiment. The results corroborated the main hypothesis of the study, i.e., that the most important factors previously screened in a previous trial could be maintained with three dose levels without altering the cultivation performance. i (i (DSD 3 (factors st ii (ii test application doses commercial dose, , dose) 27 (2 3. . 3) RBD (RBD extract 3571 35 71 35.71 experiment ie e i.e. performance 2 ( 357 7 35.7 i.e 35.

https://doi.org/10.1590/0034-737x2024710010

15.

Multivariate analysis applied to evaluate the spatial variability of a soil subjected to conservation management
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Costa, Anderson Gomide

; Silva, Carlos José da

; Fonseca, Caroline Souza da

; Gomes, João Henrique Gaia

; Pereira, Marcos Gervasio

Revista Ciência Agronômica

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2024, Volume 55 elocation e20228656

Abstract: En | Text: En | PDF: En

ABSTRACT Monitoring the spatial variability of soil attributes is an important tool in crop management. Multivariate statistical methods and geostatistics were jointly applied to evaluate the infl uence of different attributes on spatial variability in the soil. The aim of this research was to apply multivariate principal component analysis to map the spatial variability of the soil in an area subjected to different methods of conservation management and identify the most relevant physical and chemical attributes. Disturbed and undisturbed soil samples were collected and georeferenced at 99 different points in the study area at depths of 0.00 - 0.10 m and 0.10 - 0.20 m to measure the physical and chemical attributes of the soil; multivariate principal component analysis (PC) was then applied to the data. Geostatistics was applied to the PCs showing greater explanatory capacity, evaluating spatial dependence, and generating maps of spatial variability. The variance in the soil attributes was explained by the first eight PCs. Soil density, particle density and pH had the greatest infl uence on the spatial variability of the soil since they showed the highest correlation with the PC with the greatest explanatory power. The PCs that correlated with at least two of the soil attributes showed moderate (PC1 and PC6) and strong (PC2, PC4 and PC5) spatial dependence. The generated maps helped identify the joint infl uence of the variability of the most relevant attributes, making it possible to characterise regions under different methods of conservation management. 9 000 0 00 0.0 010 10 0.1 020 20 0.2 (PC data capacity dependence power PC1 PC6 PC2, PC2 (PC2 PC5 0. 01 1 02 2

https://doi.org/10.5935/1806-6690.20240041

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