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Recommendations on cutaneous and hematological manifestations of Sjögren’s disease by the Brazilian Society of Rheumatology Sjögrens Sjögren s
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Pugliesi, Alisson

; Egypto, Danielle Christinne Soares do

; Duffles, Guilherme

; Cantali, Diego Ustárroz

; Pasoto, Sandra Gofinet

; Oliveira, Fabiola Reis

; Valim, Valeria

; Lopes, Maria Lucia Lemos

; Miyamoto, Samira Tatiyama

; Fernandes, Marilena Leal Mesquita Silvestre Fialho, Sonia Cristina de Magalhães Souza Pinheiro, Aysa César Santos, Laura Caldas dos Appenzeller, Simone Ribeiro, Sandra Lucia Euzébio Libório-Kimura, Tatiana Nayara Santos, Maria Carmen Lopes Ferreira Silva Gennari, Juliana D´Agostino Pernanbuco, Roberta Capobiano, Karina Gatz Civile, Vinicius Tassoni Pinto, Ana Carolina Pereira Nunes Rocha-Filho, César Ramos Rocha, Aline Pereira da Trevisani, Virginia Fernandes Moça

Advances in Rheumatology

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2024, Volume 64 elocation 51

Abstract: En | Text: En | PDF: En

Abstract Sjogren’s disease (SjD) is an autoimmune disease that is characterized not only by the sicca symptoms it causes but also by its systemic nature, which is capable of several and not yet fully understood extraglandular manifestations. To gain a clearer understanding of these manifestations as well as a better practical approach, a panel of experts from the Brazilian Society of Rheumatology conducted a systematic review and meta-analysis on the identification of epidemiologic and clinical features of the extraglandular manifestations present in ESSDAI (EULAR Sjogren´s syndrome disease activity index), followed by a voting panel with recommendations for clinical practice. This publication is complementary to others already published and covers cutaneous and hematological manifestations, with prevalence data generated by a meta-analysis of 13 clinical or laboratory manifestations and 6 clinical management recommendations. Sjogrens Sjogren s SjD (SjD nature approach metaanalysis meta analysis EULAR index, index , index) practice 1

https://doi.org/10.1186/s42358-024-00391-x

Impact on pulmonary, cardiac, and renal function and long-term quality of life after hospitalization for acute respiratory distress syndrome due to COVID-19: Protocol of the Post-COVID Brazil 3 study pulmonary cardiac longterm long term COVID19 COVID 19 COVID-19 PostCOVID Post COVID1 1 COVID-1 COVID-
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Scolari, Fernando Luís

; Rover, Marciane Maria

; Trott, Geraldine

; da Silva, Mariana Motta Dias

; de Souza, Denise

; de Carli Schardosim, Raine Fogliati

; da Rosa Minho dos Santos, Rosa

; de Souza Roldão, Emelyn

; Mocellin, Duane

; de Souza, Jennifer Menna Barreto

; Miozzo, Aline Paula

; Rech, Gabriela Soares

; Itaqui, Carolina Rothmann

; de Mesquita Neto, Juliana

; Estivalete, Gabriel Pozza Muller

; Freitas, Hellen Jordan Martins

; dos Santos, Catherine Vitória Pereira

; da Luz, Lucas Gobetti

; Kern, Marcelo

; Marcolino, Milena Soriano

; Barreto, Bruna Brandão

; Schwartzman, Paulo R. Antonio, Ana Carolina Peçanha Falavigna, Maicon Robinson, Caroline Cabral Polanczy, Carisi Anne Rosa, Regis Goulart

Critical Care Science

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2024, Volume 36 elocation e20240258en

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Fundamento: As evidências acerca das sequelas a longo prazo após internação por síndrome do desconforto respiratório agudo por COVID-19 ainda são escassas. Objetivo: Avaliar alterações nas funções pulmonar, cardíaca e renal e na qualidade de vida após internação por síndrome do desconforto respiratório agudo secundária à COVID-19. Métodos: Trata-se de estudo multicêntrico, caso-controle, incluindo 220 participantes. Os casos serão definidos como pacientes hospitalizados por síndrome do desconforto respiratório agudo devido à COVID-19. No Grupo Controle, serão selecionados indivíduos sem histórico de hospitalização nos últimos 12 meses ou sintomas a longo prazo de COVID-19. Todos os indivíduos serão submetidos à espirometria pulmonar com teste de difusão pelo monóxido de carbono, tomografia de tórax, ressonância magnética cardíaca e renal com gadolínio, ergoespirometria, creatinina sérica e urinária, proteínas totais e microalbuminúria urinária, além de questionários de qualidade de vida. Os casos serão avaliados 12 meses após a alta hospitalar e os controles, 90 dias após a inclusão no estudo. Para todas as análises estatísticas, será assumido como significativo o valor p < 0,05. Resultados: O desfecho primário do estudo foi definido com a capacidade de difusão pulmonar aferida para o monóxido de carbono a partir de 12 meses. Os demais parâmetros das funções pulmonar, cardíacas e renal e da qualidade de vida foram definidos como desfechos secundários. Conclusão: Este estudo visa determinar as sequelas a longo prazo nas funções pulmonar, cardíaca e renal e na qualidade de vida de pacientes internados por síndrome do desconforto respiratório agudo devido à COVID-19 na população brasileira. Fundamento COVID19 COVID 19 COVID-1 escassas Objetivo COVID19. 19. Métodos Tratase Trata se multicêntrico casocontrole, casocontrole caso controle, controle caso-controle 22 participantes Controle 1 tórax gadolínio ergoespirometria urinária controles 9 estatísticas 005 0 05 0,05 Resultados secundários Conclusão brasileira COVID1 COVID- 2 00 0,0 0,

ABSTRACT Rationale: Evidence about long-term sequelae after hospitalization for acute respiratory distress syndrome due to COVID-19 is still scarce. Purpose: To evaluate changes in pulmonary, cardiac, and renal function and in quality of life after hospitalization for acute respiratory distress syndrome secondary to COVID-19. Methods: This will be a multicenter case–control study of 220 participants. Eligible are patients who are hospitalized for acute respiratory distress syndrome due to COVID-19. In the control group, individuals with no history of hospitalization in the last 12 months or long-term symptoms of COVID-19 will be selected. All individuals will be subjected to pulmonary spirometry with a carbon monoxide diffusion test, chest tomography, cardiac and renal magnetic resonance imaging with gadolinium, ergospirometry, serum and urinary creatinine, total protein, and urinary microalbuminuria, in addition to quality-of-life questionnaires. Patients will be evaluated 12 months after hospital discharge, and controls will be evaluated within 90 days of inclusion in the study. For all the statistical analyses, p < 0.05 is the threshold for significance. Results: The primary outcome of the study will be the pulmonary diffusing capacity for carbon monoxide measured after 12 months. The other parameters of pulmonary, cardiac, and renal function and quality of life are secondary outcomes. Conclusion: This study aims to determine the long-term sequelae of pulmonary, cardiac, and renal function and the quality of life of patients hospitalized for acute respiratory distress syndrome due to COVID-19 in the Brazilian population. Rationale longterm long term COVID19 COVID 19 COVID-1 scarce Purpose COVID19. 19. Methods casecontrol case 22 participants group 1 selected test tomography gadolinium ergospirometry creatinine protein microalbuminuria qualityoflife questionnaires discharge 9 analyses 005 0 05 0.0 significance Results outcomes Conclusion population COVID1 COVID- 2 00 0.

https://doi.org/10.62675/2965-2774.20240258-en

Descrição da situação epidemiológica dos profissionais de enfermagem no Brasil acometidos pela covid-19
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Neves, Gisele de Lima

; Silva, Aline Cerqueira Santos Santana da

; Martinez, Elena Araujo

; Góes, Fernanda Garcia Bezerra

; Portela, Luciana Fernandes

; Damasceno, Dayvanne Pereira Soares da Silva

Enfermería Actual de Costa Rica

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dec 2023, N. 45 elocation 56275

Abstract: Es En Pt | Text: Es En Pt | PDF: Es | PDF: En | PDF: Pt

Resumen: Introducción: El nuevo coronavirus (síndrome respiratorio agudo severo coronavirus-sars-cov-2) se ha propagado rápidamente en todo el mundo causando enfermedad conocida como COVID-19. Esta es una enfermedad respiratoria potencialmente grave, que puede ser una amenaza para la vida de miles de personas, sobre todo profesionales de salud que, debido su exposición ocupacional, son más vulnerables, por lo que integran las estadísticas de caso, la muerte y la letalidad. Objetivo: Describir la situación epidemiológica de las personas profesionales de enfermería en Brasil afectadas por COVID-19. Método: Estudio epidemiológico, observacional y descriptivo, a través de datos secundarios. Se incluyeron todas las notificaciones de COVID-19 de profesionales de salud dentro del Observatorio de Enfermería entre el 3 de abril de 2020 hasta el 26 de mayo de 2021. Los datos se enviaron al análisis descriptivo. Resultados: Se han informado 56 114 (100 %) casos. Entre las variables analizadas, el grupo de edad entre 31 y 40 años fue el más afectado, con 19 761 registros (35.21 %). Además, 784 (1.39 %) profesionales fallecieron, con mayor predominio en mujeres, de quienes hay 531 (67.72 %) notificaciones. Con respecto a la letalidad, los hombres obtuvieron el índice más alto (5.16 %). La región del sudeste notificó los casos más altos, especialmente el estado de São Paulo. El grupo de edad de 31 a 40 años tuvo la tasa de suspensión más alta bajo sospecha de COVID-19, durante la cuarentena fueron 6.074 (36.46%). Conclusión: Los resultados permitieron conocer casos de enfermedad, muerte y letalidad por Covid-19 entre profesionales de enfermería, señalando la necesidad urgente de estrategias que minimicen estos riesgos en sus entornos de trabajo.

Abstract: Introduction: The new coronavirus (Severe Acute Respiratory Syndrome Coronavirus-Sars-COV-2) has quickly spread around the world causing Coronavirus Disease 2019- COVID-19, a potentially severe respiratory disease that is a threat to life. Thousands of people, especially health professionals, increase their vulnerabilities and integrate the statistics of cases, death, and lethality due to occupational exposure. Objective: To describe the epidemiological situation of nursing professionals in Brazil affected by COVID-19. Method: Epidemiological, observational, and descriptive study using secondary data. All COVID-19 notifications were included between professionals at the Nursing Observatory from April 3, 2020, to May 26, 2021. The data were submitted to the descriptive analysis. Results: 56 114 (100 %) cases have been reported. Among the variables analyzed, the age group between 31 and 40 years old was the most affected with a total of 19 761 records (35.21 %), 784 (1.39 %) professionals died, with a greater predominance in female patients: a total of 531 (67.72 %) notifications. Regarding lethality, males added the highest index (5.16 %). The Southeast Region notified the highest cases, especially the state of São Paulo. This age group gathered the highest rate of sick leaves under Covid-19 suspicion and, during the quarantine, they constituted 36.46% (6 074 cases). Conclusion: The findings allowed us to know cases of illness, death, and lethality of COVID-19 among nursing professionals, revealing the urgent need for strategies that minimize these risks in their work environments.

Resumo: Introdução: O novo coronavírus (severe acute respiratory syndrome coronavirus - SARS-CoV-2) disseminou-se rapidamente em todo o mundo causando a Coronavirus Disease 2019 - COVID-19, uma doença respiratória potencialmente grave, que se configura como uma ameaça à vida de milhares de pessoas, sobretudo profissionais de saúde que frente à exposição ocupacional aumentam suas vulnerabilidades e integrando as estatísticas de casos, óbitos e letalidade. Objetivo: descrever a situação epidemiológica dos profissionais de enfermagem no Brasil acometidos pela COVID-19. Método: Estudo epidemiológico, observacional e descritivo, por meio de dados secundários. Foram incluídas todas as notificações de COVID-19 entre profissionais no Observatório da Enfermagem de 03 abril de 2020 até o dia 26 de maio de 2021. Os dados foram submetidos à análise descritiva. Resultados: 56.114 (100%) casos foram notificados. Dentre as variáveis analisadas, a faixa etária entre 31 a 40 anos foi a mais acometida com 19.761 registros (35,21%), 784 (1,39%) profissionais evoluíram a óbito, com maior predomínio no sexo feminino com 531 (67,72%) notificações. Com relação a letalidade, o sexo masculino somou o maior índice (5,16%). A região Sudeste notificou o maior índice de casos, com destaque para o estado de São Paulo. A faixa etária de 31 a 40 anos, reuniu os maiores índice de afastamento por suspeita de COVID-19 e, em quarentena com 6.074 (36,46%). Conclusão: Os achados permitiram conhecer casos de adoecimento, óbito e letalidade por COVID-19 entre os profissionais de enfermagem, apontando a necessidade urgente de estratégias que minimizem esses riscos em seus ambientes de trabalho.

https://doi.org/10.15517/enferm.actual.cr.i45.49006

Chikungunya virus infection in the southernmost state of Brazil was characterised by self-limited transmission (2017-2019) and a larger 2021 outbreak
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Gregianini, Tatiana Schäffer

; Salvato, Richard Steiner Barcellos, Regina Bones Godinho, Fernanda Marques Ruivo, Amanda Pellenz de Melo, Viviane Horn Schroder, Júlio Augusto Martiny, Fernanda Letícia Möllmann, Erica Bortoli Favreto, Cátia Baethgen, Ludmila Fiorenzano Ferreira, Vithoria Pompermaier de Lima, Lívia Eidt Piazza, Cláudia Fasolo Machado, Taís Raquel Marcon Becker, Irina Marieta Ramos, Raquel Rocha Frölich, Guilherme Carey Rossetti, Alana Fraga Almeida, Lucas da Cunha Rodrigues, Tahiana Machado Antunes Bragança, Isabella Tabelli Campos, Aline Alves Scarpellini Manzoni, Verônica Baú Machado, Lais Ceschini da Silva, Luisa Maria Inácio de Oliveira, André Luiz Sá Paiva, Marcelo Henrique Santos Nunes, Zenaida Marion Alves de Almeida, Paula Rodrigues Demoliner, Meriane Gularte, Juliana Schons da Silva, Mariana Soares Filippi, Micheli Pereira, Vyctoria Malayhka de Abreu Góes Spilki, Fernando Rosado da Veiga, Ana Beatriz Gorini Wallau, Gabriel Luz

Memórias do Instituto Oswaldo Cruz

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2023, Volume 118 elocation e220259

Abstract: En | Text: En | PDF: En

BACKGROUND Chikungunya is a mosquito-borne virus that has been causing large outbreaks in the Americas since 2014. In Brazil, Asian-Caribbean (AC) and East-Central-South-African (ECSA) genotypes have been detected and lead to large outbreaks in several Brazilian states. In Rio Grande do Sul (RS), the southernmost state of Brazil, the first cases were reported in 2016. OBJECTIVES AND METHODS We employed genome sequencing and epidemiological investigation to characterise the Chikungunya fever (CHIKF) burden in RS between 2017-2021. FINDINGS We detected an increasing CHIKF burden linked to travel associated introductions and communitary transmission of distinct lineages of the ECSA genotype during this period. MAIN CONCLUSIONS Until 2020, CHIKV introductions were most travel associated and transmission was limited. Then, in 2021, the largest outbreak occurred in the state associated with the introduction of a new ECSA lineage. CHIKV outbreaks are likely to occur in the near future due to abundant competent vectors and a susceptible population, exposing more than 11 million inhabitants to an increasing infection risk.

https://doi.org/10.1590/0074-02760220259

Vestibular System Eletrophysiology: An Analysis of the Relationship between Hearing and Movement
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Oliveira, Aline Cabral de

; Souza, Luana Soares Honorato de

; Daniel, Carlos Raphael Araújo

; Oliveira, Priscila Feliciano de

; Pereira, Liliane Desgualdo

International Archives of Otorhinolaryngology

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jun 2022, Volume 26 N. 2 Pages e272 - e277

Abstract: En | Text: En | PDF: En

Abstract Introduction Knowledge about the positive effects that music and dance bring, in its various forms, to the healthy human brain, is important not only in the context of basic neuroscience but may also strongly affect practices in neurorehabilitation. Objective To verify the relationship between hearing and movement and, specifically, to analyze the interference of professional dance practice and formal musical training in the magnitude of the vestibule-cervical and vestibular reflexes. Method The sample consisted of 92 subjects, aged between 18 and 35 years old, 31 professional musicians, 31 ballet dancers, and 30 control subjects. Only subjects with normal hearing sensitivity were included. Cervical vestibular evoked myogenic potential (cVEMP) was recorded in the sternocleidomastoid muscle, and ocular vestibular evoked myogenic potential (oVEMP) was recorded in the lower oblique muscle of the eye, using tone-bursts (500Hz). Analysis of variance (ANOVA) or Kruskall-Wallis tests were performed. Results The cVEMP presented earlier and higher amplitude waves when recorded in the group of dancers, with a significant difference between all tested groups for latency and amplitude of the N23 wave; the comparison was restricted between dancers and control groups, with no difference between ballet dancers and musicians. The N1 wave of the oVEMP presented lower latencies in dancers than in musicians and controls (p= 0.001). No significant differences were found between the groups for the P1 wave. Conclusion Greater magnitudes of vestibule-cervical reflex responses and faster vestibule-ocular reflex responses were observed in dancers. Dance practice provides greater development of the vestibular system, but musical training also contributes to the magnitude of these responses.

https://doi.org/10.1055/s-0041-1726044

Recommendations for evaluation and diagnosis of extra-glandular manifestations of primary Sjögren syndrome: results of an epidemiologic systematic review/ meta-analysis and a consensus guideline from the Brazilian society of rheumatology (hepatic, gastrointestinal and pancreatic)
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Trevisani, Virginia Fernandes Moça

; Pinheiro, Aysa César

; Fialho, Sonia Cristina de Magalhães Souza

; Fernandes, Marilena Leal Mesquita Silvestre

; Pugliesi, Alisson

; Pasoto, Sandra Gofinet

; Lopes, Maria Lucia Lemos

; Guedes, Lissiane Karine Noronha

; Miyamoto, Samira Tatiyama

; Santos, Laura Caldas dos

; Appenzeller, Simone

; Fidelix, Tania

; Ribeiro, Sandra Lúcia Euzébio Brito, Danielle Christinne Soares Egypto de Libório-Kimura, Tatiana Nayara Santos, Maria Carmen Lopes Ferreira Silva Cantali, Diego Ustárroz Gennari, Juliana D.’Agostino Capobianco, Karina Gatz Civile, Vinicius Tassoni Pinto, Ana Carolina Pereira Nunes Rocha, Aline Pereira da Rocha Filho, César Ramos Oliveira, Fabiola Reis Valim, Valeria

Advances in Rheumatology

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2022, Volume 62 elocation 35

Abstract: En | Text: En | PDF: En

Abstract Sjogren's syndrome (SS) is an autoimmune disease characterized by lymphocytic infiltration of the exocrine glands and other organs, associated with sicca syndrome but also with systemic involvement with varying degrees of severity. Despite their importance, some systemic manifestations, mainly liver, gastrointestinal, and pancreatic are not routinely evaluated. To address these manifestations, the Sjögren's Syndrome Committee of the Brazilian Society of Rheumatology conducted a broad systematic review of the literature on studies investigating prevalence and diagnosis of these symptoms in Sjogren´s patients and made recommendations based on the findings. Agreement between the experts was achieved using the Delphi method. This is the second part of this guideline, providing 6 recommendations for liver, gastrointestinal, and pancreatic care of SS patients.

https://doi.org/10.1186/s42358-022-00267-y

Recommendations for evaluation and diagnosis of extra-glandular manifestations of primary sjogren syndrome: results of an epidemiologic systematic review/ meta-analysis and a consensus guideline from the Brazilian Society of Rheumatology (articular, pulmonary and renal)
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Trevisani, Virginia Fernandes Moça

; Pugliesi, Alisson

; Pasoto, Sandra Gofinet

; Lopes, Maria Lucia Lemos

; Guedes, Lissiane Karine Noronha

; Miyamoto, Samira Tatiyama

; Fernandes, Marilena Leal Mesquita Silvestre

; Fialho, Sonia Cristina de Magalhães Souza

; Pinheiro, Aysa César

; Santos, Laura Caldas dos

; Appenzeller, Simone Fidelix, Tania Ribeiro, Sandra Lúcia Euzébio Brito, Danielle Christinne Soares Egypto de Libório-Kimura, Tatiana Nayara Santos, Maria Carmen Lopes Ferreira Silva Cantali, Diego Ustárroz Gennari, Juliana D’Agostino Civile, Vinicius Tassoni Pinto, Ana Carolina Pereira Nunes Rocha-Filho, César Ramos Oliveira, Fabiola Reis Rocha, Aline Pereira da Valim, Valeria

Advances in Rheumatology

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2022, Volume 62 elocation 18

Abstract: En | Text: En | PDF: En

Abstract Sjogren’s Syndrome (SS) is an autoimmune disease characterized by lymphocytic infiltration of the exocrine glands and other organs, associated with sicca syndrome but also with systemic involvement with varying degrees of severity. Despite their importance, these systemic manifestations are not routinely evaluated and there is no homogenous approach to their diagnosis or evaluation. To close this gap, a panel of experts from the Brazilian Society of Rheumatology conducted a systematic review and meta-analysis on the identification of epidemiologic and clinical features of these manifestations and made recommendations based on the findings. Agreement between the experts was achieved using the Delphi method. The first part of this guideline summarizes the most important topics, and 11 recommendations are provided for the articular, pulmonary, and renal care of SS patients.

https://doi.org/10.1186/s42358-022-00248-1

Uso de serviços de saúde bucal entre idosos brasileiros: mediação pela perda dentária
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Santos, Aline Soares Figueiredo

; Lima, Renata Francine Rodrigues

; Ferreira, Raquel Conceição

; Alencar, Gizelton Pereira

; Carreiro, Danilo Lima

; Silveira, Marise Fagundes

; Trezena, Samuel

; Martins, Andrea Maria Eleutério de Barros Lima

Ciência & Saúde Coletiva

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2022, Volume 27 N. 7 Pages 2777 - 2788

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Analisaram-se fatores associados ao uso de serviços de saúde bucal (USSB) entre idosos brasileiros. Estudo transversal, que considerou a amostra de 7.619 idosos (65-74 anos) do SB Brasil 2010. Utilizou-se modelagem com equações estruturais (MEE), investigando associação entre variáveis latentes ou observadas, de forma direta ou mediada, em relação ao USSB. Utilizaram-se estimadores de mínimos quadrados ajustados pela média e variância, por meio de coeficientes padronizados, erro padrão e intervalos de confiança, com o método bootstrapping com 1.500 iterações. Idosos com melhor condição socioeconômica, menor número de dentes perdidos e presença de impactos das condições de saúde bucal em sua vida foram associados de forma direta ao desfecho. Ainda estiveram associados ao USSB de forma mediada, a condição socioeconômica, sexo e idade; bem como o uso de próteses; além de se encontrar correlação entre uso de próteses e dentes perdidos. A perda dentária exerceu papel de destaque, apontando para a necessidade de ampliação do acesso às próteses dentárias na atenção básica.

Abstract The present study analyzed factors associated with the use of oral health services among elderly Brazilians. This was a cross-sectional study with data from the latest National Oral Health Survey (SB Brazil 2010), which considered a sample of 7,619 elderly individuals (65-74 years) for analysis. Structural Equation Modeling (SEM) was used, investigating the association between latent or observed variables, directly or mediated, in relation to the use of oral health services. Least squares estimators adjusted by mean and variance, were used by means of standardized coefficients, and standard error and confidence intervals, by applying the bootstrapping method with 1,500 iterations. Elderly individuals with a higher socioeconomic status, fewer missing teeth, and the presence of impacts of oral health conditions on their lives were directly associated with the outcome. Other factors associated with the mediated use of oral health services among elderly Brazilians included socioeconomic status, gender, age, and the use of prostheses, in addition to finding a correlation between prosthesis use and missing teeth. Tooth loss, along with other factors, played a prominent role in this study regarding the use of oral health services among elderly Brazilians, pointing to the need to expand access to dental prostheses in primary care.

https://doi.org/10.1590/1413-81232022277.22122021

Uso de serviços de saúde bucal entre idosos brasileiros: mediação pela perda dentária
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Santos, Aline Soares Figueiredo

; Lima, Renata Francine Rodrigues

; Ferreira, Raquel Conceição

; Alencar, Gizelton Pereira

; Carreiro, Danilo Lima

; Silveira, Marise Fagundes

; Trezena, Samuel

; Martins, Andrea Maria Eleutério de Barros Lima

Ciência & Saúde Coletiva

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2022, Volume 27 N. 7 Pages 2777 - 2788

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.1590/1413-81232022277.22122021

10.

PERFIL EPIDEMIOLÓGICO DE CRIANÇAS INFECTADAS PELO NOVO CORONAVÍRUS: ESTUDO TRANSVERSAL
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Damasceno, Dayvanne Pereira Soares da Silva

; Silva, Aline Cerqueira Santos Santana da

; Portela, Luciana Fernandes

; Góes, Fernanda Garcia Bezerra

; Martinez, Elena Araujo

; Neves, Gisele de Lima

Cogitare Enfermagem

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2022, Volume 27 elocation e82798

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

RESUMO Objetivo: descrever o perfil epidemiológico de crianças infectadas pelo novo coronavírus a partir das notificações dos casos ao Ministério da Saúde. Método: estudo epidemiológico, transversal e descritivo, realizado por meio das notificações no Sistema de Informação de Vigilância Epidemiológica da Gripe da primeira à vigésima semana epidemiológica de 2021. Foram incluídas as notificações de crianças de zero a nove anos. As variáveis foram analisadas por meio de análises bivariadas e da regressão logística multivariada. Resultados: foram notificados 3.041 casos, dentre os quais 414 (13,6%) confirmaram o diagnóstico de COVID-19. Crianças entre seis e nove anos tem 1,33 vezes mais chance de desenvolverem COVID-19 e internar em unidade de tratamento intensivo (RC=1,46; IC de: 1,12-1,87), além de ter maior chance (RC=3,30; IC: 1,92-5,66) de evoluir para óbito. Conclusão: os achados contribuem para orientar e modular intervenções que visam mitigar a transmissão e controle de agravos acerca da COVID-19 frente à criança.

ABSTRACT Objective: to describe the epidemiological profile of children infected by the new coronavirus from the notifications of cases to the Ministry of Health. Method: epidemiological, cross-sectional, and descriptive study, carried out through the notifications in the Epidemiological Surveillance Information System of Influenza from the first to the twentieth epidemiological week of 2021. Notifications from children aged zero to nine years were included. Variables were analyzed using bivariate analysis and multivariate logistic regression. Results: 3,041 cases were notified, among which 414 (13.6%) confirmed the diagnosis of COVID-19. Children between six and nine years old were 1.33 times more likely to develop COVID-19 and be admitted to the intensive care unit (CR=1.46; CI: 1.12-1.87) and had a greater chance (CR=3.30; CI: 1.92-5.66) of dying. Conclusion: the findings contribute to guide and modulate interventions aimed at mitigating transmission and control of aggravations about COVID-19 in children.

RESUMEN Objetivo: describir el perfil epidemiológico de los niños infectados por el nuevo coronavirus a partir de las notificaciones de casos al Ministerio de Sanidad. Método: estudio epidemiológico, transversal y descriptivo, realizado a través de las notificaciones en el Sistema de Información de Vigilancia Epidemiológica de la Gripe desde la primera hasta la vigésima semana epidemiológica de 2021. Se incluyeron las notificaciones de niños de cero a nueve años. Las variables se analizaron mediante un análisis bivariante y una regresión logística multivariante. Resultados: Se notificaron 3.041 casos, de los cuales 414 (13,6%) confirmaron el diagnóstico de COVID-19. Los niños de entre seis y nueve años tienen 1,33 veces más probabilidades de desarrollar COVID-19 e ingresar en la unidad de cuidados intensivos (CR=1,46; IC: 1,12-1,87), además de tener más probabilidades (CR=3,30; IC: 1,92-5,66) de morir. Conclusión: los resultados contribuyen a orientar y modular las intervenciones destinadas a mitigar la transmisión y el control de los efectos de la COVID-19 en los niños.

https://doi.org/10.5380/ce.v27i0.82798

11.

Carbonized rice husk as an alternative substrate for Ocimum basilicum L. seedling production
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Salé, Mussa Mamudo Pereira, Aline Soares Lange Junior, Hélio Neutzling, Cristiane Marques dos Santos, Patricia Schiedeck, Gustavo Severo Dorneles, Athos Odin

Acta Agronómica

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mar 2021, Volume 70 N. 1 Pages 93 - 100

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Abstract The substrate used in seedling production plays a major role in the initial plant development. In this sense, the objective was to evaluate the emergence capacity and establishment of basil seedlings in different proportions of alternative substrates based on charred rice husk and commercial substrate S10®. The experiment was carried out in expanded polyethylene trays, using basil seeds (Horticeres seeds®), which lasted 28 days. The experimental design was completely randomized, with five treatments (T1: 100 % commercial substrate (BCS); T2: 80 % BCS + 20 % Charred rice husk (CRH); T3: 60 % BCS + 40 % CRH; T4: 40 % BCS + 60 % CRH; T5: 20 % BCS + 80 % CRH) and three repetitions. Were evaluated leaf number, shoot length, root length, root dry mass, shoot dry mass, leaf area, germination, germination speed index, substrate physical analysis (density (dry and wet)), total porosity and aeration space, and chemical analysis (hydrogen potential (PH), and electrical conductivity (EC)). It was observed in the results that the substrate type interferes in the development and quality of the basil seedling. In the shoot lenght parameter, the treatment with 40 % BCS + 60 % CRH (T4) had a significant difference compared to the other treatments. Among the substrates, the best seedling performance was observed in the substrate with 80 % BCS + 20 % CRH (T2), which provided better seedling quality in relation to the other treatments.

Resumen El sustrato utilizado en la producción de plántulas juega un papel importante en el desarrollo inicial de la planta. En este sentido, el objetivo fue evaluar la capacidad de emergencia y el establecimiento de plántulas de albahaca en diferentes proporciones de sustratos alternativos basados en cáscara de arroz carbonizada y sustrato comercial S10®. El experimento se realizó en bandejas de polietileno expandido, utilizando semillas de albahaca (Horticeres seeds®), durante 28 días. El diseño experimental fue completamente al azar, con cinco tratamientos (T1: sustrato comercial 100 % (BCS); T2: 80 % BCS + 20 % cáscara de arroz carbonizada (CRH); T3: 60 % BCS + 40 % CRH; T4: 40 % BCS + 60 % CRH; T5: 20 % BCS + 80 % CRH) y tres repeticiones. Se evaluaron el número de hojas; la longitud del brote; la longitud de la raíz; la masa seca de la raíz; la masa seca del brote; el área de la hoja; la germinación; el índice de velocidad de germinación; el análisis físico del sustrato (densidad (seco y húmedo)); la porosidad total y el espacio de aireación; y análisis químico (potencial de hidrógeno (PH) y conductividad eléctrica (CE)). En los resultados se observó que el tipo de sustrato interfiere en el desarrollo y la calidad de las plántulas de albahaca. En el parámetro de longitud de yema, el tratamiento con 40 % BCS + 60 % CRH (T4) mostró una diferencia significativa con respecto a los otros tratamientos. Entre los sustratos, se observó el mejor rendimiento de plántulas en el sustrato con 80 % de BCS + 20 % de CRH (T2), lo que proporcionó una mejor calidad de plántulas en relación con los otros tratamientos.

https://doi.org/10.15446/acag.v70n1.87771

12.

Associação entre supervisão parental e comportamento sedentário e de inatividade física em adolescentes brasileiros
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Santana, Clara Pereira

; Nunes, Hiago Alessandro Soares

; Silva, Aline Natália

; Azeredo, Catarina Machado

Ciência & Saúde Coletiva

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feb 2021, Volume 26 N. 2 Pages 569 - 580

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Avaliamos associações da supervisão parental com o comportamento sedentário e a inatividade física em adolescentes brasileiros. Utilizamos dados da Pesquisa Nacional de Saúde do Escolar (PeNSE) de 2015, que avaliou 102.072 escolares do 9° ano. Consideramos sedentários os adolescentes que ficavam ≥3 horas/dia sentados e inativos os que praticaram <60 min/dia de atividade física. A supervisão parental foi avaliada pela frequência (nunca, às vezes, sempre) de atividades com verificar o dever, saber sobre o tempo livre e entender os problemas do adolescente. Foram realizadas análises de regressão logística, ajustadas para variáveis sociodemográficas. Dentre os avaliados, 56,3% eram sedentários e 78,1% inativos. Verificar atividades escolares se associou à menor odds de inatividade e sedentarismo. Ter ciência do que o adolescente fazia no tempo livre e mexer nas coisas do adolescente se associaram a menor odds de inatividade física. A compreensão de problemas pelos responsáveis se associou à menor odds de sedentarismo. Concluímos que maior supervisão parental se associou a menor sedentarismo e menor inatividade física entre adolescentes.

Abstract The scope of this study was to assess the association between parental supervision and sedentary behavior and physical inactivity among Brazilian adolescents. Data of 102,072 students attending 9th grade from public and private school gathered in the 2015 Brazilian National Survey of School Health (PeNSE) were used. Adolescents were sedentary and physical inactive when they spent ≥3 hours/day sitting and practiced less then 60min/day of physical activity, respectively. Frequency of parental supervision (never, sometimes, always) was assessed through checking school homework, knowledge about what the adolescents do in their free time and understanding their problems. Logistic regression was applied and duly adjusted for sociodemographic variables. Among the adolescents, 56.3% were sedentary and 78.1% were inactive. Checking school homework was associated with lower odds of physical inactivity and sedentary behavior. Knowing what adolescents did in their free time and inspecting their belongings was associated with lower odds of physical inactivity. The understanding of problems by parents/guardians was associated with lower odds of sedentary behavior. The conclusion drawn is that greater parental supervision is associated with less physical inactivity and less sedentary behavior.

https://doi.org/10.1590/1413-81232021262.07272019

13.

Associação entre supervisão parental e comportamento sedentário e de inatividade física em adolescentes brasileiros
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Santana, Clara Pereira

; Nunes, Hiago Alessandro Soares

; Silva, Aline Natália

; Azeredo, Catarina Machado

Ciência & Saúde Coletiva

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feb 2021, Volume 26 N. 2 Pages 569 - 580

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.1590/1413-81232021262.07272019 1475 downloads

14.

Low back pain prevalence in Parkinson's disease
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Gonçalves, Bernardo Machado

; Barezani, André Luis Silveira

; Feital, Aline Michele Batista de Figueiredo

; Souza, Mariana Soares de

; Christo, Paulo Pereira

; Scalzo, Paula Luciana

BrJP

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dec 2020, Volume 3 N. 4 Pages 310 - 313

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO JUSTIFICATIVA E OBJETIVOS: A dor lombar é um sintoma não motor comumente relatado por indivíduos com doença de Parkinson. O objetivo deste estudo foi identificar a prevalência de dor lombar e suas características em indivíduos com doença de Parkinson em um centro de tratamento especializado. MÉTODOS: Indivíduos com doença de Parkinson idiopática responderam a um questionário para a avaliação de parâmetros clínicos e sintomas de dor associados. A intensidade da dor foi avaliada utilizando a escala analógica visual. RESULTADOS: Cento e vinte e três pacientes com idade média de 68,1±11,8 anos e duração média da doença de 7,0±4,9 anos responderam o questionário. A dor foi relatada por 102 (82,9%) pacientes: 71 (57,7%) com dor lombar e 31 (25,2%) com dor em outros segmentos corporais. Não houve diferença quanto à idade, escolaridade, tempo de sintomas e de diagnóstico da doença de Parkinson ao comparar os indivíduos com e sem dor, assim como indivíduos com dor em outras regiões e dor lombar. O grupo com dor lombar queixava-se de dor em maior número de segmentos corporais além da região lombar, com maior tempo de duração desse sintoma e uso mais frequente de analgésicos. Dentre os indivíduos do grupo com dor lombar, as mulheres apresentavam maior intensidade da dor. CONCLUSÃO: Os resultados mostraram alta prevalência da dor em indivíduos com doença de Parkinson, especificamente da dor lombar.

ABSTRACT BACKGROUND AND OBJECTIVES: Low back pain is a non-motor symptom commonly reported by individuals with Parkinson's disease. The aim of this study was to identify the prevalence of low back pain and its characteristics in individuals with Parkinson disease from a specialized treatment center. METHODS: Individuals with idiopathic Parkinson's disease answered a questionnaire for the assessment of clinical parameters and associated pain symptoms. Pain intensity was assessed using the visual analog scale. RESULTS: One hundred and twenty-three patients with mean age 68.1±11.8 years, and disease duration of 7.0±4.9 years, answered the questionnaire. Pain was reported by 102 (82.9%) patients: 71 (57.7%) had low back pain and 31 (25.2%) had pain in other body segments. There was no difference in age, education, time of Parkinson's disease symptoms and diagnosis when comparing individuals with and without pain, as well as individuals with pain in other segments and low back pain. The group with low back pain had pain in a greater number of body segments in addition to the lumbar region, with longer duration of this symptom and more frequent use of analgesic drugs. In the low back pain group, women had greater pain intensity. CONCLUSION: The results show the high prevalence of pain in individuals with Parkinson's disease, specifically low back pain.

https://doi.org/10.5935/2595-0118.20200192 827 downloads

15.

Establishment of a simple and efficient platform for car-t cell generation and expansion: from lentiviral production to in vivo studies
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Picanço-Castro, Virgínia

; Moço, Pablo Diego Mizukami, Amanda Vaz, Leticia Delfini Pereira, Marcelo de Souza Fernandes Silvestre, Renata Nacasaki Azevedo, Júlia Teixeira Cottas de Bomfim, Aline de Sousa Abreu Neto, Mario Soares de Malmegrim, Kelen Cristina Ribeiro Swiech, Kamilla Covas, Dimas Tadeu

Hematology, Transfusion and Cell Therapy

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jun 2020, Volume 42 N. 2 Pages 150 - 158

Abstract: En | Text: En | PDF: En

ABSTRACT Introduction: Adoptive transfer of T cells expressing a CD19-specific chimeric antigen receptor (CAR) has shown impressive response rates for the treatment of CD19 + B-cell malignancies in numerous clinical trials. The CAR molecule, which recognizes cell-surface tumor-associated antigen independently of human leukocyte antigen (HLA), is composed by one or more signaling molecules to activate genetically modified T cells for killing, proliferation, and cytokine production. Objectives: In order to make this treatment available for a larger number of patients, we developed a simple and efficient platform to generate and expand CAR-T cells. Methods: Our approach is based on a lentiviral vector composed by a second-generation CAR that signals through a 41BB and CD3-ζ endodomain. Conclusions: In this work, we show a high-level production of the lentiviral vector, which was successfully used to generate CAR-T cells. The CAR-T cells produced were highly cytotoxic and specific against CD19+ cells in vitro and in vivo, being able to fully control disease progression in a xenograft B-cell lymphoma mouse model. Our work demonstrates the feasibility of producing CAR-T cells in an academic context and can serve as a paradigm for similar institutions. Nevertheless, the results presented may contribute favoring the translation of the research to the clinical practice.

https://doi.org/10.1016/j.htct.2019.06.007 548 downloads

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