Abstract The aim of the present study was to assess the agronomic performance and chemical composition of soil cultivated with palisade grass (Urochloa brizantha cv. Marandu) subjected to growing doses of liquid blood waste. The experiment followed the completely randomized blocks design with six treatments and four repetitions. The following doses of processed liquid blood waste were applied to test palisade grass’ yield: 0, 150, 300, 450 and 600 m3 ha-1. In addition, it was used in conjunction with chemical fertilization at a rate of 50 kg ha-1 of P2O5 and 100 kg ha-1 of N (this treatment was not managed with liquid blood residue). Palisade grass forage yield was influenced by the fertilization strategy (P<0.001) - the highest values observed for this variable were recorded under blood waste doses of 450 m3 ha-1 and 600 m3 ha-1. The 0.0 - 0.20 m soil layer affect the organic matter fraction. On the other hand, phosphorus (P) content presented differences between fertilization strategies; thus, it was possible observing that the waste dose of 450 m3 ha-1 accounted for the highest availability of nutrients. The application of blood liquid waste as alternative source of organic fertilizers can be feasible, because it promotes significant increase in forage mass.

Resumen El objetivo fue evaluar el comportamiento agronómico y la composición química de suelos cultivados con pasto insurgente (Urochloa brizantha cv. Marandu) sometido a dosis crecientes de residuos sanguíneos líquidos. El experimento siguió el diseño de bloques completamente al azar con seis tratamientos y cuatro repeticiones. Las siguientes dosis de residuos sanguíneos líquidos procesados se aplicaron para analizar el rendimiento del pasto insurgente: 0, 150, 300, 450 y 600 m3 ha-1. Además, se utilizó en conjunto con la fertilización química a razón de 50 kg ha-1 de P2O5 y 100 kg ha-1 de N (este tratamiento no se manejó con residuos sanguíneos líquidos). El rendimiento de forraje de pasto insurgente estuvo influenciado por la estrategia de fertilización (P<0.001) - los valores más altos observados para esta variable se registraron bajo dosis de residuos sanguíneos de 450 m3 ha-1 y 600 m3 ha-1. La capa de suelo de 0.0 a 0.20 m afecta a la fracción de materia orgánica. Por otro lado, el contenido de fósforo (P) presentó diferencias entre las estrategias de fertilización; así, fue posible observar que la dosis de residuos de 450 m3 ha-1 resultó en la mayor disponibilidad de nutrientes. La aplicación de residuos sanguíneos líquidos como fuente alternativa de fertilizantes orgánicos puede ser factible, ya que promueve un aumento significativo de la masa forrajera.

Abstract Introduction: Heterogeneity in the epidemiology, management, and in-hospital outcomes of patients with acute aortic syndromes can be found among male and female populations. This study aims to analyze sex-related differences in a cohort of patients treated in a tertiary university center. Methods: All patients admitted with acute aortic syndromes between January 2012 and January 2023 were retrospectively analyzed. A descriptive analysis of the data was performed, and the results were queried to explore sex-related differences according to the type of aortic syndrome, type of treatment (medical or surgical - conventional or endovascular), and the temporal phase of the disease in which this treatment occurred. A multivariable logistic regression was undertaken to identify variables associated with higher in-hospital mortality. Variables were included if statistically significant in the univariable analysis or if considered medically relevant. Results: A total of 116 patients (69% male) were included. Women were older (median age [interquartile range]: 64.6 years [40-85 years], n=36 versus 58.7 [23-84], n=80; P=0.034), had a higher proportion of intramural hematoma (19.4% versus 5.0%, P=0.014) and a lower proportion of aortic dissection (72.2% versus 88.8%, P=0.026) compared to men. Both sexes were more frequently treated with medical therapy alone (33.6%). However, women had a trend towards a lower proportion of open surgical management compared to men (16.7% versus 23.8%, P=0.391), as well as higher in-hospital mortality associated with this type of treatment (50.0% versus 21.1%, P=0.169). Additionally, women were associated with a higher conversion to endovascular or open surgery when first managed conservatively (13.9% versus 3.8%, P=0.046). In binary logistic regression, age was associated with higher in-hospital mortality (OR 1.056 [95% CI, 1.01-1.10]; P=0.014), but not female sex (OR 1.133 [95% CI, 0.39-3.30]; P=0.819). Conclusion: Women were older, had more intramural hematoma, and were associated with a higher conversion from medical to surgical treatment. After multivariable regression, age was associated with higher in-hospital mortality, but female sex was not. Larger cohorts are needed to understand if intervention in female patients will have an impact on intra-hospital mortality.

BACKGROUND Leishmania tarentolae is a non-pathogenic species found in lizards representing an important model for Leishmania biology. However, several aspects of this Sauroleishmania remain unknown to explain its low level of virulence. OBJECTIVES We reported several aspects of L. tarentolae biology including glycoconjugates, proteolytic activities and metabolome composition in comparison to pathogenic species (Leishmania amazonensis, Leishmania braziliensis, Leishmania infantum and Leishmania major). METHODS Parasites were cultured for extraction and purification of lipophosphoglycan (LPG), immunofluorescence probing with anti-gp63 and resistance against complement. Parasite extracts were also tested for proteases activity and metabolome composition. FINDINGS Leishmania tarentolae does not express LPG on its surface. It expresses gp63 at lower levels compared to pathogenic species and, is highly sensitive to complement-mediated lysis. This species also lacks intracellular/extracellular activities of proteolytic enzymes. It has metabolic differences with pathogenic species, exhibiting a lower abundance of metabolites including ABC transporters, biosynthesis of unsaturated fatty acids and steroids, TCA cycle, glycine/serine/threonine metabolism, glyoxylate/dicarboxylate metabolism and pentose-phosphate pathways. MAIN CONCLUSIONS The non-pathogenic phenotype of L. tarentolae is associated with alterations in several biochemical and molecular features. This reinforces the need of comparative studies between pathogenic and non-pathogenic species to elucidate the molecular mechanisms of virulence during host-parasite interactions. nonpathogenic non However L glycoconjugates amazonensis braziliensis major. major . major) LPG, , (LPG) antigp63 antigp anti gp anti-gp6 complement surface gp6 complementmediated mediated lysis intracellularextracellular intracellular extracellular enzymes transporters steroids cycle glycineserinethreonine glycine serine threonine glyoxylatedicarboxylate glyoxylate dicarboxylate pentosephosphate pentose phosphate pathways features hostparasite host parasite interactions (LPG antigp6 anti-gp

RESUMO Objetivo: Analisar o custo cognitivo no trabalho dos policiais militares do estado do Rio de Janeiro. Método: Trata-se de um estudo de corte transversal com abordagem quantitativa, realizado com 446 policiais militares, de ambos os sexos, distribuídos entre praças e oficiais, nos 7°, 15°, 20°, 24° e 41° batalhões de Polícia Militar. Utilizou-se um instrumento para a caracterização sociodemográfica, laboral, hábitos de vida e condições de saúde e uma escala de avaliação do custo humano no trabalho, que analisa as exigências relativas ao trabalho por meio dos custos físico, cognitivo e afetivo. Os dados foram organizados, processados e analisados com o auxílio do programa Statistical Package for the Social Sciences (SPSS), versão 13.1. Resultados: O custo cognitivo apresentou as maiores médias, com resultados graves (μ = 3,86; DP = 0,86), representando maior exigência em relação ao custo humano no trabalho entre os policiais militares do estado do Rio de Janeiro e associações significativas em relação à obesidade, alterações cognitivas de atenção e memória, idade e horas de sono. Conclusão: Na avaliação do custo humano no trabalho, o custo cognitivo foi o mais exigido no contexto de trabalho dos policiais militares pesquisados apresentando um risco grave para o adoecimento. Objetivo Método Tratase Trata se quantitativa 44 sexos oficiais 7 7° 15 15° 20 20° 24 41 Militar Utilizouse Utilizou sociodemográfica laboral físico afetivo organizados SPSS, SPSS , (SPSS) 131 13 1 13.1 Resultados médias μ 3,86 386 3 86 0,86, 086 0,86 0 0,86) obesidade memória sono Conclusão adoecimento 4 2 (SPSS 13. 3,8 38 8 08 0,8 3, 0,

ABSTRACT Objective: To assess the cognitive cost of work for military police officers in the state of Rio de Janeiro. Method: This is a cross-sectional study with a quantitative approach, carried out with 446 military police officers, of both sexes, distributed between non-commissioned officers and officers, in the 7th, 15th, 20th, 24th and 41st Military Police Battalions. An instrument was used to depict sociodemographic, work, lifestyle and health conditions and a scale for assessing the human cost of work, which analyses the demands of the job through physical, cognitive and affective costs. The data was organized, processed and analyzed using the Statistical Package for the Social Sciences (SPSS) software, version 13.1. Results: The cognitive cost had the highest means, with severe results (μ = 3.86; SD = 0.86), representing greater demands in relation to the human cost of work among military police officers in the state of Rio de Janeiro and significant associations in relation to obesity, cognitive alterations in attention and memory, age and hours of sleep. Conclusion: In assessing the human cost of work, the cognitive cost was the most demanding in the work context of the military police officers surveyed, presenting a serious risk of illness. Objective Method crosssectional cross sectional approach 44 sexes noncommissioned non commissioned 7th th 15th 20th st Battalions sociodemographic physical costs organized SPSS (SPSS software 131 13 1 13.1 Results means μ 3.86 386 3 86 0.86, 086 0.86 , 0 0.86) obesity memory sleep Conclusion surveyed illness 4 13. 3.8 38 8 08 0.8 3. 0.

RESUMEN Objetivo: Analizar los costos cognitivos producidos por el trabajo de los policías militares del estado de Rio de Janeiro. Método: Se trata de un estudio transversal con abordaje cuantitativo, realizado con 446 policías militares, de ambos sexos, distribuidos entre cuadros y oficiales, de los Batallones 7°, 15°, 20°, 24° y 41° de la Policía Militar. Se utilizó un instrumento para caracterizar las condiciones sociodemográficas, laborales, de estilo de vida y de salud, y una escala para evaluar el costo humano del trabajo, que analiza las exigencias del trabajo a través de los costos físicos, cognitivos y afectivos. Los datos fueron organizados, procesados y analizados utilizando el software Statistical Package for the Social Sciences (SPSS), versión 13.1. Resultados: El costo cognitivo presentó las medias más altas, con resultados graves (μ = 3,86; SD = 0,86), representando mayores exigencias en relación al costo humano del trabajo entre los policías militares del estado de Río de Janeiro y asociaciones significativas en relación a la obesidad, alteraciones cognitivas de atención y memoria, edad y horas de sueño. Conclusión: Al evaluar el coste humano del trabajo, el coste cognitivo fue el más exigente en el contexto laboral de los policías militares encuestados, presentando un grave riesgo de enfermedad. Objetivo Método cuantitativo 44 sexos oficiales 7 7° 15 15° 20 20° 24 41 Militar sociodemográficas laborales salud físicos afectivos organizados SPSS, SPSS , (SPSS) 131 13 1 13.1 Resultados altas μ 3,86 386 3 86 0,86, 086 0,86 0 0,86) obesidad memoria sueño Conclusión encuestados enfermedad 4 2 (SPSS 13. 3,8 38 8 08 0,8 3, 0,

RESUMO O tráfico humano, assunto fortemente midiatizado na virada dos anos 2000 e 2010, voltou a ter repercussão pública em âmbito nacional durante a campanha política para a presidência da República em 2022, na fala de Damares Alves, correligionária do então candidato à reeleição Jair Bolsonaro. Neste artigo, analisamos a potência sedutora da temática e mostramos o efeito desastroso de entendimentos moralizantes a respeito do deslocamento de mulheres para a inserção no mercado sexual. Nossa perspectiva encontra estudos antropológicos como, por exemplo, os de Jo Doezema, Adriana Piscitelli e Marcia Sprandel. Analisamos inquéritos policiais e processos criminais datados de entre 1995 e 2012 - período em que o tráfico de pessoas para exploração sexual se tornou uma questão no Brasil -, motivados pela seguinte provocação: se todos somos contra a exploração sexual, o que temos em comum com Damares Alves? humano 200 2010 2022 Alves Bolsonaro artigo como exemplo Doezema Sprandel 199 201 , provocação 20 202 19 2 1

ABSTRACT Human trafficking, a subject that was heavily mediatized at the turn of the 2000s and 2010s, once again had public repercussions at the national level during the political campaign for the presidency of the Republic in 2022, in the speech by Damares Alves, a co-religionist of then candidate for re-election Jair Bolsonaro. In this article, we analyse the seductive power of the topic and show the disastrous effect of moralizing understandings about the displacement of women to enter the sex market. Our perspective is based on anthropological studies such as those by Jo Doezema, Adriana Piscitelli and Marcia Sprandel. We analyzed police inquiries and criminal cases dating from 1995 to 2012 - the period in which human trafficking for sexual exploitation became an issue in Brazil - motivated by the following provocation: if we are all against sexual exploitation, what do we have in common with Damares Alves? s 2010s 2022 Alves coreligionist co religionist reelection re election Bolsonaro article market Doezema Sprandel 199 201 provocation 202 19 20 1 2

ABSTRACT Objective: To evaluate the cumulative incidence, risk factors, and outcomes of COVID-19 in patients with Cushing's disease (CD). Subjects and methods: In all, 60 patients with CD following up in our outpatient clinic answered via phone interview a questionnaire about the occurrence of COVID-19 infection documented by RT-PCR (including the diagnosis date and clinical outcome) and vaccination status. Clinical and biochemical data on disease activity (hypercortisolism) and comorbidities (obesity, diabetes mellitus, and hypertension) were obtained from the patients' electronic medical records. Risk ratios (RRs) of risk factors were obtained using univariate and multivariate analyses. Results: The cumulative incidence of COVID-19 in patients with CD during the observation period was 31.7%, which was higher than that in the general reference population (9.5%). The cumulative incidence of COVID-19 was significantly higher in patients with hypercortisolism (57% versus 17% in those without hypercortisolism, p = 0.012) and obesity (54% versus 9% in those without obesity, p < 0.001) but not in patients with hypertension or diabetes mellitus. On multivariate analysis, hypercortisolism and obesity were each independent risk factors for COVID-19 (RR 2.18, 95% CI 1.06-4.46, p = 0.033 and RR 5.19, 95% CI 1.61-16.74, p = 0.006, respectively). Conclusion: The incidence of COVID-19 in patients with CD was associated with hypercortisolism, as expected, and obesity, a novel and unexpected finding. Thus, correction of hypercortisolism and obesity should be implemented in patients with CD during the current and future COVID-19 outbreaks. Objective COVID19 COVID 19 COVID-1 Cushings Cushing s CD. . (CD) methods all 6 RTPCR RT PCR including outcome status (hypercortisolism (obesity mellitus records RRs (RRs analyses Results 317 31 7 31.7% 9.5%. 95 9.5% 9 5 (9.5%) 57% 57 (57 17 0.012 0012 0 012 54% 54 (54 0.001 0001 001 analysis 218 2 18 2.18 1.064.46, 106446 1.06 4.46, 1 06 4 46 1.06-4.46 0033 033 0.03 519 5.19 1.6116.74, 1611674 1.61 16.74, 61 16 74 1.61-16.74 0006 006 0.006 respectively. respectively respectively) Conclusion expected finding Thus outbreaks COVID1 COVID- (CD 3 31.7 9.5 (9.5% (5 0.01 01 0.00 000 00 21 2.1 064 1.064.46 10644 106 1.0 446 4.46 1.06-4.4 003 03 0.0 51 5.1 6116 1.6116.74 161167 161 1.6 1674 16.74 1.61-16.7 31. 9. (9.5 ( 2. 1.064.4 1064 10 1. 44 4.4 1.06-4. 0. 5. 611 1.6116.7 16116 167 16.7 1.61-16. (9. 1.064. 4. 1.06-4 1.6116. 1611 16. 1.61-16 (9 1.064 1.06- 1.6116 1.61-1 1.611 1.61-

RESUMO Introdução: A Universidade Estadual Paulista (Unesp) implantou o sistema de cotas (ações afirmativas) para ingressantes em 2014, por meio do sistema de reserva de vagas destinada a alunos oriundos de escolas públicas. As principais ressalvas quanto ao sistema de cotas dizem respeito às dificuldades de adaptação desses alunos ao meio acadêmico universitário, que poderiam interferir em seu desempenho durante a graduação. Por isso, é necessário conhecer o desempenho desses alunos para poder propor alternativas viáveis para suas necessidades. Objetivo: Este estudo teve como objetivo avaliar o desempenho acadêmico pelo coeficiente de rendimento (CR) escolar dos egressos do curso de Medicina da Faculdade de Medicina de Botucatu (FMB) da Unesp segundo forma de ingresso no vestibular. Método: Foram avaliados os CR finais dos alunos que finalizaram o curso de Medicina nos anos de 2019, 2020 e 2021. Os dados foram obtidos na Seção de Graduação da FMB. Realizaram-se comparações das médias do CR entre os grupos (ingresso universal - IU e ação afirmativa - AA). Resultado: No período de 2019 a 2021, graduaram-se 252 alunos: 184 do IU (73%) e 68 (27%) de AA. A média geral do CR foi de 8,41 + 0,61. As médias do CR dos alunos do IU foram de 8,45 + 0,61 e de AA de 8,31 + 0,60 (p = 0,414). Conclusão: A análise do CR dos formados em três anos do curso de Medicina da FMB revela que o desempenho dos ingressantes por AA e IU é semelhante. Introdução (Unesp ações afirmativas 2014 públicas universitário graduação isso necessidades Objetivo (CR (FMB vestibular Método 202 2021 Realizaramse Realizaram se . AA) Resultado 201 graduaramse graduaram 25 18 73% 73 (73% 6 27% 27 (27% 841 8 41 8,4 061 0 61 845 45 0,6 831 31 8,3 060 60 p 0,414. 0414 0,414 414 0,414) Conclusão semelhante 20 2 1 7 (73 (27 84 4 8, 06 0, 83 3 041 0,41 (7 (2 04 0,4 (

ABSTRACT Introduction: São Paulo State University (Unesp) implemented the quota system (affirmative action) for first-year students in 2014, through the vacancy reservation system for students from public schools. The main caveats regarding the quota system concern the difficulties these students have in adapting to the university academic environment, which could interfere with their performance during undergraduate school. Therefore, it is necessary to know about the performance of these students to propose viable alternatives for their needs. Objective: This study aimed to evaluate the academic performance through the academic performance coefficient (APC) of undergraduate students of the medical course at the Botucatu School of Medicine - Unesp (BSM) according to the type of university admission process. Methods: the final APC of students who completed the medical course in the years 2019, 2020, and 2021 were evaluated. The data were obtained from the Undergraduate Section of BSM. Comparisons were made of APC means between groups (universal admission - UA and affirmative action - AA). Results: In the period from 2019 to 2021, 252 students graduated, 184 from UA (73%) and 68 (27%) from AA. The general average of the APC was 8.41 + 0.61. The APC averages of the UA students were 8.45 + 0.61 and the AA averages were 8.31 + 0.60 (p = 0.414). Conclusion: The APC analysis of graduates over three years of the BSM medical course shows that the performance of those admitted through AA and by UA is similar Introduction (Unesp firstyear first year 2014 schools environment school Therefore needs Objective (APC (BSM process Methods 2020 202 evaluated universal . AA) Results 201 25 graduated 18 73% 73 (73% 6 27% 27 (27% 841 8 41 8.4 061 0 61 845 45 0.6 831 31 8.3 060 60 p 0.414. 0414 0.414 414 0.414) Conclusion 20 2 1 7 (73 (27 84 4 8. 06 0. 83 3 041 0.41 (7 (2 04 0.4 (

ABSTRACT Introduction: Atrial fibrillation is the main complication in the postoperative period of cardiovascular surgery. Its genesis is multifactorial, so its rapid identification to mitigate the associated risks is essential. Objective: To evaluate the incidence of atrial fibrillation in patients undergoing coronary artery bypass grafting (CABG) and its relationship with other complications in our setting. Methods: This is a multicenter, observational study involving patients undergoing isolated CABG between 2017 and 2019 with data from the Registro Paulista de Cirurgia Cardiovascular (or REPLICCAR II). Variables were prospectively collected in REDCap following the definitions given by version 2.73 of the Society of Thoracic Surgeons Adult Cardiac Surgery Database. Data were collected with prior authorization from the local ethics committee and analyses performed in R software. Results: A total of 3,803 patients were included, of these 605 had postoperative atrial fibrillation (POAF). In order to adjust the groups, propensity score matching was used. Such analyses resulted in 605 patients in each group (without POAF vs. with POAF). Among patients with POAF, the mean age was 67.56 years, with a prevalence of males (73.6%, 445 patients). Patients belonging to the group with POAF had a mortality rate of 9.26% (P=0.007), longer ventilation time (P<0.001), pneumonia (P<0.001), and sepsis (P<0.001). In multiple analysis, acute renal dysfunction (P=0.032) and longer intensive care unit stay (P<0,001) were associated with the presence of POAF. Conclusion: POAF in CABG is associated with longer intensive care unit and hospital stay, as well as renal dysfunction, pneumonia, and in-hospital mortality. Introduction surgery multifactorial essential Objective (CABG setting Methods multicenter 201 or II. II . II) 273 2 73 2.7 Database software Results 3803 3 803 3,80 included 60 (POAF) groups used without vs POAF) 6756 67 56 67.5 years 73.6%, 736 6 (73.6% 44 patients. patients) 926 9 26 9.26 P=0.007, P0007 P P=0.007 , 0 007 (P=0.007) P<0.001, P0001 P<0.001 001 (P<0.001) P<0.001. analysis P=0.032 P0032 032 (P=0.032 P<0,001 (P<0,001 Conclusion inhospital 20 27 7 2. 380 80 3,8 (POAF 675 5 67. 73.6% (73.6 4 92 9.2 P000 P=0.00 00 (P=0.007 P<0.00 (P<0.001 P=0.03 P003 03 (P=0.03 P<0,00 (P<0,00 38 8 3, 73.6 (73. 9. P00 P=0.0 (P=0.00 P<0.0 (P<0.00 (P=0.0 P<0,0 (P<0,0 73. (73 P0 P=0. P<0. (P<0.0 (P=0. P<0, (P<0, (7 P=0 P<0 (P<0. (P=0 (P<0 ( P= P< (P= (P< (P

ABSTRACT Purpose: To evaluate the effects of curcumin supplementation on abdominal surgical wound healing in rats using clinical, histological, and hematological parameters. Methods: Forty Wistar rats were randomly divided into two groups: the curcumin group, and the control group. The curcumin group received, in addition to water and standard feed, curcumin via gavage at the dose of 200 mg/kg for seven days preceding and seven days following surgery. The control group received only water and standard feed. Both groups underwent median laparotomy and left colotomy. On the eighth postoperative day, the groups were euthanized, and the left colon was resected for histological analysis. Results: In the preoperative evaluation, there was a significant decrease in the mean C-reactive protein levels in the curcumin group (0.06) compared to the control group (0.112) (p = 0.0001). In the postoperative wound healing assessment, a significant decrease was observed in inflammatory infiltrate (p = 0.0006) and blood vessel count (p = 0.0002) in the curcumin group compared to the control group. Conclusions: Curcumin supplementation was able to significantly reduce inflammatory parameters in both pre-and post-operative phases of abdominal surgical wounds in rats. Purpose clinical Methods feed 20 mgkg mg kg surgery colotomy day euthanized analysis Results evaluation Creactive C reactive 0.06 006 0 06 (0.06 0.112 0112 112 (0.112 p 0.0001. 00001 0.0001 . 0001 0.0001) assessment 0.0006 00006 0006 0.0002 00002 0002 Conclusions preand pre post operative 2 0.0 00 (0.0 0.11 011 11 (0.11 0000 0.000 000 0. (0. 0.1 01 1 (0.1 0.00 (0 (

Purpose This study aims to answer the question of how to structure a circular ecosystem for extractive fishing in the Amazon region. It explores possibilities for implementing a circular ecosystem management model in an imperfect market with low technological availability, high informality and limited public assistance. Design/methodology/approach Qualitative approach was adopted for this paper, with a case study on extractive fishing in the state of Amazonas. Data was collected through 35 interviews and direct observation of the processes of collecting, storing and transporting fish on two routes: Tapauá-Manaus and Manacapuru-Manaus. Findings Through the data collected, it was possible to observe the importance of an orchestrating agent – such as an association or even a public authority – for the establishment and development of a circular ecosystem for extractive fishing in the region. Research limitations/implications The paper makes theoretical contributions by presenting how a circular ecosystem management model could be implemented for an imperfect market in the Global South, as well as contributing to the literature on how the circular economy contributes to mitigate the threat to biodiversity posed by the linear economy. Practical implications It contributes to the management practice of structuring circular ecosystems. Social implications The role of public authorities and the collective organization of fishermen as orchestrators connecting the network of actors that develop the extractive fishing ecosystem is fundamental, guaranteeing effective social participation in solving local problems. Originality/value The idea of circular ecosystems was applied to imperfect contexts, with high informality, weak institutions and bioeconomy, topics still little explored in the literature. region availability assistance Designmethodologyapproach Design methodology Amazonas 3 collecting routes TapauáManaus Tapauá Manaus ManacapuruManaus. ManacapuruManaus Manacapuru Manaus. Manacapuru-Manaus limitationsimplications limitations South fundamental problems Originalityvalue Originality value contexts bioeconomy

Resumo A Serra do Ibitipoca ocorre no sudeste do estado de Minas Gerais, sudeste do Brasil, e inclui um mosaico de diferentes tipos de vegetação, como parte do domínio da Mata Atlântica. Tal heterogeneidade é resultado da ocorrência de diversos ecótonos na região, considerados áreas de amortecimento essenciais para manutenção da biodiversidade e estrutura de ecossistemas adjacentes. Dada a importância destes ambientes para conservação da biodiversidade, inventários florísticos são importantes para catalogar a riqueza de plantas em áreas naturais, onde espécies e paisagens têm sido destruídas, especialmente nas últimas décadas. Para contribuir com o aumento do conhecimento sobre a Flora vascular na Serra do Ibitipoca, um inventário florístico foi conduzido em áreas privadas adjacentes ao Parque Estadual do Ibitipoca. As descobertas mais relevantes do presente estudo incluem: caracterização dos diferentes tipos de vegetação, 17 novos registros para a Flora de Minas Gerais, coleta de 288 espécies nunca registradas para o parque (80% de dissimilaridade – especialmente devido à ocorrência e tamanho de diferentes fitofisionomias entre as áreas) e presença de 31 espécies ameaçadas. Além disso, discussões sobre esforços para conservação e políticas públicas são apresentadas. Gerais Brasil vegetação Atlântica região naturais destruídas décadas incluem 1 28 80% 80 (80 3 ameaçadas disso apresentadas 2 8 (8 (

Abstract The Ibitipoca Mountains occur in southeastern Minas Gerais state, Southeast Brazil, and includes a mosaic of different vegetation types, as part of the Atlantic Forest domain. Such heterogeneity results in the occurrence of several ecotones in the region, considered essential buffer zones for maintaining biodiversity and structure among adjacent ecosystems. Given the importance of these environments for biodiversity conservation, floristic surveys are important to catalogue plant richness in natural areas, where species and landscapes have been destroyed, especially over the last decades. To contribute to increase the knowledge on the vascular Flora in the Ibitipoca Mountains, a floristic inventory was undertaken in private properties located in the boundaries of “Parque Estadual do Ibitipoca” (Ibitipoca State Park). Relevant findings of the present study include: characterization of the different vegetation types, 17 new records for the Flora of Minas Gerais, collection of 288 species never recorded in the state park (80% dissimilarity – especially due to the occurrence and size of different phytophysiognomies between these areas) and presence of 31 threatened species. In addition, discussions about conservation efforts and public policies are presented. Brazil types domain region ecosystems areas destroyed decades Parque Park. Park . Park) include 1 28 80% 80 (80 3 addition presented 2 8 (8 (

Abstract Objective: To evaluate and compare the sexual function and pelvic floor muscles (PFM) function of women with endometriosis and chronic pelvic pain (CPP) with and without Myofascial Pelvic Pain Syndrome (MPPS). Methods: Cross-sectional study conducted between January 2018 and December 2020. Women with deep endometriosis underwent assessments for trigger points (TP) and PFM function using the PERFECT scale. Electromyographic activity (EMG) and sexual function through Female Sexual Function Index (FSFI) were assessed. Statistical analyses included chi-square and Mann-Whitney tests. Results: There were 46 women. 47% had increased muscle tone and 67% related TP in levator ani muscle (LAM). Weakness in PFM, with P≤2 was noted in 82% and P≥3 in only 17%. Incomplete relaxation of PFM presented in 30%. EMG results were resting 6.0, maximal voluntary isometric contraction (MVIC) 61.9 and Endurance 14.2; FSFI mean total score 24.7. We observed an association between increased muscle tone (P<.001), difficulty in relaxation (P=.019), and lower Endurance on EMG (P=.04) in women with TP in LAM. Participants with TP presented lower total FSFI score (P=.02). TP in the right OIM presented increased muscle tone (P=.01). TP in the left OIM presented lower values to function of PFM by PERFECT (P=.005), and in MVIC (P=.03) on EMG. Conclusion: Trigger points (TP) in pelvic floor muscles (PFM) and obturator internus muscle (OIM) correlates with poorer PFM and sexual function, particularly in left OIM TP cases. Endometriosis and chronic pelvic pain raise muscle tone, weaken muscles, hinder relaxation, elevate resting electrical activity, lower maximum voluntary isometric contraction, and reduce PFM endurance. Objective (PFM CPP (CPP MPPS. MPPS . (MPPS) Methods Crosssectional Cross sectional 201 2020 (TP scale (EMG (FSFI assessed chisquare chi square MannWhitney Mann Whitney tests Results 4 47 67 LAM (LAM) P2 P 2 P≤ 82 P3 3 P≥ 17 17% 30 30% 60 6 0 6.0 (MVIC 619 61 9 61. 14.2 142 14 247 24 7 24.7 P<.001, P001 P<.001 , 001 (P<.001) P=.019, P019 P=.019 019 (P=.019) P=.04 P04 04 (P=.04 P=.02. P02 P=.02 02 (P=.02) P=.01. P01 P=.01 01 (P=.01) P=.005, P005 P=.005 005 (P=.005) P=.03 P03 03 (P=.03 Conclusion (OIM cases endurance (MPPS 20 202 (LAM 8 1 6. 14. 24. P00 P<.00 00 (P<.001 (P=.019 P=.0 P0 (P=.0 (P=.02 (P=.01 P=.00 (P=.005 P<.0 (P<.00 P=. (P=. (P=.00 P<. (P<.0 P= (P= P< (P<. (P (P<