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au:Pauletti, Patricia

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O GÊNERO Fridericia (BIGNONIACEAE): COMPOSIÇÃO QUÍMICA E POTENCIAL BIOLÓGICO BIGNONIACEAE (BIGNONIACEAE) (BIGNONIACEAE
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Henrique, Camila Y.

; Alves, Osvaine J. A.

; Silva, Márcio L. A. e

; Cunha, Wilson R.

; Januario, Ana H.

; Pauletti, Patrícia M.

Química Nova

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2024, Volume 47 N. 1 elocation e-20230088

Abstract: Pt | Text: Pt | PDF: Pt

The genus Fridericia belongs to the family Bignoniaceae and comprises 60 species that occur in humid to dry forests, cerrado, and caatinga vegetation. It may be found from Mexico to Argentina and southern Brazil. This article reviews studies conducted on this genus, primarily focusing on its chemical composition and biological activities. Of the 60 known Fridericia species, only 14 have been the object of chemical and biological studies, accounting for 23% of the researched species. Eighty-four compounds, mainly flavonoids, terpenes, xanthones, and phenylethanoids, have been isolated from these species. The biological properties described in this review include antimicrobial, antioxidant, anti-inflammatory, hepatoprotective, antiviral, healing, antiproliferative, trypanocidal, and antileishmania activities. Notably, the species F. chica has been the most studied, as it is listed in the National List of Medicinal Plants of Interest to the Brazilian Unified Health System (RENISUS). 6 forests cerrado vegetation Brazil activities 1 23 Eightyfour Eighty four compounds flavonoids terpenes xanthones phenylethanoids antimicrobial antioxidant antiinflammatory, antiinflammatory anti inflammatory, inflammatory anti-inflammatory hepatoprotective antiviral healing antiproliferative trypanocidal Notably F studied RENISUS. RENISUS . (RENISUS) 2 (RENISUS

https://doi.org/10.21577/0100-4042.20230088

Chemical study of Adenocalymma axillarum crude leaf extract and isolated compounds
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Andrade, João Paulo Campos

; Alves, Osvaine Junior Alvarenga

; Costa, Marian Caroline

; Gimenez, Valéria Maria Melleiro

; Squarisi, Iara Silva

; Nicolella, Heloiza Diniz

; Pagotti, Mariana Cintra

; Tavares, Denise Crispim

; Cunha, Wilson Roberto

; Silva, Márcio Luís Andrade e

; Januario, Ana Helena

; Magalhães, Lizandra Guidi

; Pauletti, Patrícia Mendonça

Brazilian Journal of Pharmaceutical Sciences

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2022, Volume 58 elocation e20278

Abstract: En | Text: En | PDF: En

Abstract Adenocalymma axillarum (K.Schum.) L.G. Lohmann is a liana belonging to the family Bignoniaceae. In traditional medicine, the genus Adenocalymma is used to treat fever, skin ailments, and body, joint, and facial muscle pains, and it is also applied as cosmetic. Biological assays conducted with the A. axillarum crude leaf ethanol extract have indicated leishmanicidal activity and absence of cytotoxicity. This study aimed to analyze the A. axillarum leaf ethanol crude extract by high-performance liquid chromatography-high-resolution mass spectrometry- diode array detector (HPLC-HRMS-DAD) and to evaluate the leishmanicidal and cytotoxic activities of this crude extract, its fractions, and isolated compounds. HPLC-HRMS-DAD analysis of this extract revealed that it consisted mainly of flavonoids, with nine major compounds. Extract purification yielded 4-hydroxy-N-methylproline, 6-β-hydroxyipolamiide, quercetin-3-O-robinobioside, hyperin, isorhamnetin-3-O-robinobioside, and 3’-O-methylhyperin, which were identified by Nuclear Magnetic Resonance. The isolated compounds were inactive against Leishmania amazonensis promastigotes and human lung fibroblast cells.

https://doi.org/10.1590/s2175-97902022e20278

MOLECULAR NETWORKING-BASED DEREPLICATION OF AMBUIC ACID DERIVATIVES FROM THE MARINE FUNGUS PESTALOTIOPSIS SP. 4A11
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Kellner Filho, Luis C.

; Assis, Rhenner N. A.

; Santos, Aline O. dos

; Targanski, Sabrina K.

; Siqueira, Kátia A.

; Medeiros, Livia S. de

; Angolini, Célio F. F.

; Silva, Felipe M. A. da

; Soares, Marcos A.

; Dias, Gustavo M.

; Silva, Marcio L. A.

; Cunha, Wilson R.

; Pauletti, Patricia M.

; Koolen, Hector H. F.

; Januario, Ana H.

Química Nova

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2022, Volume 45 N. 3 Pages 268 - 274

Abstract: En | Text: En | PDF: En

Ambuic acid (AA) is a highly-modified cyclohexenone and known as a promising inhibitor of quorum sensing in methicillin-resistant Staphylococcus aureus, and is thus a candidate as an antivirulence drug. This molecule is mainly produced by the species of Pestalotiopsis and, since its discovery twenty years ago, only a restricted amount of AA-derivatives have been described. Despite being a promising subject, methods for the analysis of modified AA-analogues via mass spectrometry remain unexplored. In order to adress this question, the marine fungus Pestalotiopsis sp. 4A11 associated with the ascidian Didemnum perlucidum was grown in a solid rice medium and its crude extract was chemically studied. From this extract, AA and 10-hydroxy ambuic acid (10-HAA) were isolated and identified using NMR spectroscopy with the aim of obtaining model compounds for the MS analysis. These served as reference compounds (seeds) to guide the dereplication of other AA-analogues via LC-MS/MS-based molecular networking. Based on the manual interpretation of the fragmentation pathways of the seeds and related compounds observed in the networks, six AA-derivatives were dereplicated in the extract. Furthermore, three analogues with unprecedented chemical formulas were proposed as putative unprecedented AA-derivatives. The fragmentation annotation proposed represents a fast and feasible method for characterizing AA-derivatives.

https://doi.org/10.21577/0100-4042.20170819

ANTIPROMASTIGOTE AND CYTOTOXIC ACTIVITIES OF FLAVONOIDS FROM Fridericia speciosa LEAVES
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Milani, Reinaldo R.

; Alves, Osvaine J. A.

; Bertanha, Camila S.

; Gimenez, Valéria M. M.

; Squarisi, Iara S.

; Nicolella, Heloiza D.

; Pagotti, Mariana C.

; Tavares, Denise C.

; Silva, Márcio L. A. e

; Cunha, Wilson R.

; Magalhães, Lizandra G.

; Januario, Ana H.

; Pauletti, Patricia M.

Química Nova

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dec 2020, Volume 43 N. 10 Pages 1404 - 1407

Abstract: En | Text: En | PDF: En

Fridericia speciosa (Bignoniaceae) is a liana that occurs in humid to dry vegetation in eastern and southeastern Brazil. Species belonging to the genus Fridericia are employed as medicinal plants. This study evaluates the antipromastigote and cytotoxic activities of the crude extract, fractions, and compounds isolated from F. speciosa, and an HPLC (High-Performance Liquid Chromatography) analytical method was used to quantify the bioactive flavonoids. The flavonoids alpinetin (1), luteolin (2), diosmetin (3), and apigenin (4) were isolated from the active EtOAc-soluble fraction (EAF) of the crude ethanol extract (LCE) obtained from F. speciosa leaves. Both LCE and EAF were active against the normal human lung fibroblast cell line GM07492A (IC50 of 460.7 µg mL-1 and 381.4 µg mL-1, respectively). Only EAF showed activity against Leishmania amazonensis (80.4% at 50 µg mL-1). Compounds 1 and 2 were quantified by HPLC-DAD in both LCE (1: 6.21%; 2: 1.11%) and EAF (1: 45.32%; 2: 2.00%). At 100 µM, compounds1-4 inhibited L. amazonensis flagellar motility by 40.2%, 26.8%, 1.0%, and 24.8%, respectively, while their toxicities (IC50) to the normal cell were > 1000, 353.0, 766.2, and >1000 µg mL-1, respectively. Therefore, F. speciosa leaves are a prolific source of bioactive flavonoids.

https://doi.org/10.21577/0100-4042.20170628 159 downloads

Isolation, in vitro and in silico Evaluation of Phenylethanoid Glycoside from Arrabidaea brachypoda as Lipoxygenase Inhibitor
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Bertanha, Camila S.

; Gimenez, Valéria M. M.

; Furtado, Ricardo A.

; Tavares, Denise C.

; Cunha, Wilson R.

; Silva, Márcio L. A. e

; Januario, Ana H.

; Borges, Alexandre

; Kawano, Daniel F.

; Parreira, Renato L. T.

; Pauletti, Patrícia M.

Journal of the Brazilian Chemical Society

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apr 2020, Volume 31 N. 4 Pages 849 - 855

Abstract: En | Text: En | PDF: En

Lipoxygenase (LOX) plays an important role in inflammatory processes and Arrabidaea brachypoda (DC.) Bureau (Bignoniaceae) has been described as presenting anti-inflammatory activity. Therefore, the objective of this study was to develop a high-performance liquid chromatography (HPLC) procedure to directly recognize LOX inhibitor compounds in A. brachypoda crude extract, facilitating the isolation, characterization of bioactive compounds, evaluation of natural compounds using an in vitro 15-LOX assay and prediction of the most probable binding modes of their main constituent through molecular docking simulations. The chemical analysis was performed by ethanol crude extract microfractionation using HPLC-DAD (diode array detector) associated to a fraction collector. The bioactive chromatogram displayed a peak with 50.9% LOX inhibition at 13.6 min retention time. The extract was purified and conandroside was isolated, presenting a LOX inhibitory activity with an inhibitory concentration (IC50) of 7.8 ± 1.1 µM, close to standard quercetin (IC50 7.6 ± 0.3 µM). Additionally, conandroside was not cytotoxic to normal cells (GM07492A). The LOX-conandroside complex displayed a slightly higher docking score (92.7) than quercetin (71.5). These results together suggest that conandroside could be explored as lipoxygenase inhibitor.

https://doi.org/10.21577/0103-5053.20190248 328 downloads

Effects of Light Quality and Chemical Elicitors on the Growth Parameters and Rosmarinic Acid Content of in vitro Cultures of Hyptis pectinata (L.) Poit.
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Pedroso, Rita C. N.

; Pimenta, Leticia P.

; Tozatti, Marcos G.

; Branquinho, Núbia A. A.

; Hara, Alessandra C. B. A. M.

; Silva, Fernando H. L.

; Costa, Alan C.

; Silva, Fabiano G.

; Miranda, Carlos E. S.

; Silva, Marcio L. A.

; Cunha, Wilson R.

; Pauletti, Patricia M.

; Januario, Ana H.

Journal of the Brazilian Chemical Society

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nov 2019, Volume 30 N. 11 Pages 2430 - 2437

Abstract: En | Text: En | PDF: En

Hyptis pectinata (L.) Poit is a folk medicinal species in Northeast Brazil. In this work, seedlings of H. pectinata were cultured in vitro under diverse light quality spectra and under the influence of two distinct chemical elicitors, salicylic acid and silver nitrate (SN), at concentrations of 30 and 60 μM. Growth parameters, biomass and rosmarinic acid (RA) content were evaluated. RA may be associated with the functional properties of this plant. In the light quality experiments, the highest level of rosmarinic acid was found under red light (161.65 ± 8.64 μg g-1 DW (dry weight)) at 20 days (4.26-fold higher than the control white light). Among the evaluated elicitors, elicitation with 60 μM SN at 3 days and 30 μM SN at 6 days favored the highest rosmarinic acid content (6361.70 ± 216.96 and 4542.98 ± 92.53 μg g-1 DW, respectively), with relatively high biomass yield and a similar number of leaves and height as those of control seedlings. This approach is new for H. pectinata.

https://doi.org/10.21577/0103-5053.20190159 385 downloads

Antiplasmodial evaluation of Anacardium occidentale and alkyl-phenols
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Gimenez, Valéria M.M.

; Alvarenga, Tavane A.

; Groppo, Milton

; Silva, Márcio L.A. e

; Cunha, Wilson R.

; Januário, Ana H.

; Smilkstein, Martin J.

; Riscoe, Michael K.

; Pauletti, Patricia M.

Revista Brasileira de Farmacognosia

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feb 2019, Volume 29 N. 1 Pages 36 - 39

Abstract: En | Text: En | PDF: En

Abstract The ethanol crude extract from cashew (Anacardium occidentale L. Anacardiaceae) displayed significant antiplasmodial activity (IC50 0.577 µg/ml). Liquid chromatography-high resolution Mass spectrometry analysis was performed to identify the main compounds existing in the ethanol extract. The occurrence of anacardic acids, cardols, and 2-methylcardols derivatives was confirmed in the extract. The IC50 obtained, when the main isolated compounds were evaluated in Plasmodium falciparum D6 strain, ranged from 5.39 µM to >100 µM. Tested here for the first time, the data showed that cardol triene 1 (IC50 = 5.69 µM) and 2-methylcardol triene 4 (IC50 = 5.39 µM) demonstrated good antimalarial activity. In conclusion, Anacardium occidentale nuts presented relevant biological potential, and further studies should be considered.

https://doi.org/10.1016/j.bjp.2018.11.003 630 downloads

Effect of salicylic acid and silver nitrate on rutin production by Hyptis marrubioides cultured in vitro
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Pedroso, Rita Cássia Nascimento

; Branquinho, Núbia Angélica de Ávila

; Hara, Alessandra Cristina Boffino de Almeida Monteiro

; Silva, Fabiano Guimarães

; Kellner Filho, Luis Claudio

; Silva, Marcio Luís Andrade

; Cunha, Wilson Roberto

; Pauletti, Patricia Mendonça

; Januário, Ana Helena

Ciência Rural

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2019, Volume 49 N. 2 elocation e20180278

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO: Hyptis marrubioides (Lamiaceae) é uma planta medicinal nativa do Cerrado brasileiro. Técnicas de propagação in vitro fazem uso de elicitores para alterar as vias metabólicas, afetando a produção de moléculas qualitativa e quantitativamente. Este trabalho teve como objetivo avaliar como os elicitores abióticos ácido salicílico (SA) e nitrato de prata (SN) nas concentrações de 30µM ou 60µM influenciam no crescimento de plântulas de Hyptis marrubioides por dois diferentes métodos de cultivo in vitro. O teor de rutina foi quantificado por CLAE-DAD. Em comparação com uma cultura não tratada, os extratos metanólicos de H. marrubioides cultivados em meio MS por 10 dias, seguidos de cultura em meio MS contendo SN (30µM) por 20 dias, apresentaram 1,28 vezes maior teor de rutina. Em um segundo experimento, as plântulas foram cultivadas em meio MS por 20 dias, e então o elicitor desejado foi adicionado à cultura e deixado em contato com o meio por três e seis dias. SA (30µM) forneceu os melhores resultados na produção de rutina, sendo 16,56 vezes maior do que o controle após seis dias. SN (30µM) aumentou o teor de rutina em 1,17 vezes. Nas duas concentrações avaliadas durante os experimentos de elicitação, nem SA nem SN alteraram os parâmetros de crescimento, como comprimento da parte aérea, número de folhas ou peso fresco e seco das plântulas de H. marrubioides cultivadas in vitro em relação ao controle. Com base nestes resultados, os elicitores abióticos SA e SN forneceram com sucesso Hyptis marrubioides in vitro com maior conteúdo de rutina.

ABSTRACT: Hyptis marrubioides (Lamiaceae) is a medicinal plant that is native from Brazilian Cerrado. In vitro propagation techniques make use of elicitors to alter metabolic pathways, affecting how molecules are produced both qualitatively and quantitatively. This research aimed to evaluate how abiotic elicitors salicylic acid (SA) and silver nitrate (SN) at concentrations of 30µM or 60µM influence Hyptis marrubioides seedling growth by two different in vitro culture methods. The rutin content was quantified by HPLC-DAD. Compared to an untreated culture, the H. marrubioides methanolic extracts cultured in MS medium for 10 days followed by culture in MS medium containing SN (30µM) for 20 days had 1.28 times higher rutin content. In a second experiment, seedlings were cultured in MS medium for 20 days, and then the desired elicitor was added to the culture and allowed to remain in contact with the medium for three and six days. SA (30µM) gave the best results: rutin production was 16.56-foldhigher than the control after six days. SN (30µM) increased the rutin content by 1.17-fold. At the two concentrations evaluated during the elicitation experiments, neither SA nor SN altered the growth parameters shoot length, leaf number, and fresh and dry weight of H. marrubioides seedlings grown in vitro as compared to the control. Based on these results, the abiotic elicitors SA and SN successfully provide Hyptis marrubioides with increased rutin content in vitro.

https://doi.org/10.1590/0103-8478cr20180278 1807 downloads

An overview of migratory birds in Brazil
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Somenzari, Marina

; Amaral, Priscilla Prudente do

; Cueto, Víctor R.

; Guaraldo, André de Camargo

; Jahn, Alex E.

; Lima, Diego Mendes

; Lima, Pedro Cerqueira

; Lugarini, Camile

; Machado, Caio Graco

; Martinez, Jaime

; Nascimento, João Luiz Xavier do

; Pacheco, José Fernando

; Paludo, Danielle

; Prestes, Nêmora Pauletti

; Serafini, Patrícia Pereira

; Silveira, Luís Fábio

; Sousa, Antônio Emanuel Barreto Alves de

; Sousa, Nathália Alves de

; Souza, Manuella Andrade de

; Rodrigues Telino-Júnior, Wallace

; Whitney, Bret Myers

Papéis Avulsos de Zoologia

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2018, Volume 58 elocation e20185803

Abstract: En | Text: En | PDF: En

Abstract We reviewed the occurrences and distributional patterns of migratory species of birds in Brazil. A species was classified as migratory when at least part of its population performs cyclical, seasonal movements with high fidelity to its breeding grounds. Of the 1,919 species of birds recorded in Brazil, 198 (10.3%) are migratory. Of these, 127 (64%) were classified as Migratory and 71 (36%) as Partially Migratory. A few species (83; 4.3%) were classified as Vagrant and eight (0,4%) species could not be defined due to limited information available, or due to conflicting data.

https://doi.org/10.11606/1807-0205/2018.58.03 8318 downloads

10.

Effect of Endophytic Fungal Associations on the Chemical Profile of in vitroVochysia divergens Seedlings
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Parpinelli, Bruna A. S.

; Siqueira, Katia A.

; Kellner Filho, Luis C.

; Pimenta, Letícia P.

; Costa, Ricardo M. da

; Parreira, Renato L. T.

; Veneziani, Rodrigo C. S.

; Silva, Marcio L. Andrade e

; Cunha, Wilson R.

; Pauletti, Patrícia M.

; Soares, Marcos A.

; Januario, Ana H.

Journal of the Brazilian Chemical Society

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dec 2017, Volume 28 N. 12 Pages 2375 - 2381

Abstract: En | Text: En | PDF: En

Vochysia divergens (Vochysiaceae) is considered an invasive species in the wetlands of the Brazilian Pantanal, which hinders the cultivation of agricultural species. In this study, we evaluated the chemical profile by HPLC-DAD (high-performance liquid chromatography-diode array detector) of leaves extracts from V. divergens seedlings inoculated with endophytic fungi isolated from V. divergens roots. These fungi were collected on dry (D) and wet (W) seasons in the Pantanal. The presence of tannin hexahydroxydiphenoyl (HHDP)-galloyl-glucose and flavone 3',5'-dimethoxy-luteolin were predominant in the seedlings inoculated with endophytic fungi W experiments at 100 and 80%, respectively. Likewise, flavone 3',5-dimethoxy-luteolin-7-O-β-glucoside showed a similar representation in the two evaluated periods, compared with 5-methoxy-luteolin, which was detected only in seedlings inoculated with W endophytic fungi. This approach is new to V. divergens, which has no scientific data on its in vitro elicitation, in the search for a better understanding of the ecological relationships of this species.

https://doi.org/10.21577/0103-5053.20170091 597 downloads

11.

DEVELOPMENT AND VALIDATION OF AN HPLC-DAD ANALYTICAL METHOD TO QUANTIFY 5-METHOXYFLAVONES IN METHANOLIC EXTRACTS OF Vochysia divergens POHL CULTURED UNDER STRESS CONDITIONS
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Pimenta, Letícia Pereira

; Kellner Filho, Luís Claúdio

; Parpinelli, Bruna Arruda Soares

; Siqueira, Katia Aparecida de

; Soares, Marcos Antônio

; Silva, Márcio Luís Andrade e

; Cunha, Wilson Roberto

; Pauletti, Patrícia Mendonça

; Januário, Ana Helena

Química Nova

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sep 2017, Volume 40 N. 9 Pages 971 - 975

Abstract: En | Text: En | PDF: En

Vochysia divergens Pohl, known as "Cambara" in Brazil, is an invasive species that is expanding throughout Pantanal in Brazil, to form mono-dominant communities. This expansion is affecting the agricultural areas that support the typical seasonal flood and drought conditions of this biome. This article describes the development and validation of an HPLC-DAD analytical method to quantify 5-methoxyflavones in methanolic extracts of greenhouse-grown V. divergens associated with one of two endophytic fungal species Zopfiella tetraspora (Zt) or Melanconiella elegans (Me) and later subjected to water stress. The developed method gave good validation parameters and was successfully applied to quantify the flavones 3',5-dimethoxy luteolin-7-O-β-glucopyranoside (1), 5-methoxy luteolin (2), and 3',5-dimethoxy luteolin (3) in the target extracts. Inoculation of the plant with Zt decreased the concentration of flavone 1 in the extract by 2.69-fold as compared to the control. Inoculation of the plant with Zt or Me did not significantly alter the contents of flavones 2 and 3 in the extracts as compared to the control. Therefore, the aerial parts of germinated V. divergens plants inoculated with either Zt or Me responded differently in terms of the production of flavones. These results can cast light on the symbiosis between fungal microorganisms and V. divergens, which most likely influences the response of V. divergens to changes in the availability of water in Pantanal.

https://doi.org/10.21577/0100-4042.20170096 796 downloads

12.

Impact of light quality on flavonoid production and growth of Hyptis marrubioides seedlings cultivated in vitro
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Pedroso, Rita Cassia N.

; Branquinho, Núbia Angelica A.

; Hara, Alessandra C.B.A.M.

; Costa, Alan Carlos

; Silva, Fabiano Guimarães

; Pimenta, Leticia P.

; Silva, Marcio Luiz A.

; Cunha, Wilson Roberto

; Pauletti, Patricia M.

; Januario, Ana Helena

Revista Brasileira de Farmacognosia

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aug 2017, Volume 27 N. 4 Pages 466 - 470

Abstract: En | Text: En | PDF: En

ABSTRACT Hyptis marrubioides Epling, Lamiaceae, a species from Brazilian Cerrado, has been used against gastrointestinal infections, skin infections, pain, and cramps. Herein, H. marrubioides seedlings were cultured in vitro under different wavelengths (white, blue, green, red, and yellow) with 50 µmol m-2 s-1 irradiance and a 16-h photoperiod. After 20 and 30 days of cultivation, shoot length, leaf number, fresh mass, and dry mass were evaluated. The flavonoid rutin content was determined by the HPLC-DAD method. The shoots were longer in plants cultivated under yellow (16.603 ± 0.790 cm, 1.8-fold), red (15.465 ± 0.461 cm, 1.7-fold), and green (14.677 ± 0.737 cm, 1.6-fold) lights than in control plants exposed to white light (9.203 ± 0.388 cm). The number of leaves increased in plants exposed to red (23.425 ± 1.138, 1.1-fold) and green (22.725 ± 1.814, 1.1-fold) lights, compared to control plants (20.133 ± 0.827). Fresh (0.665 ± 0.048 g, 1.2-fold) and dry (0.066 ± 0.005 g, 1.3-fold) mass of seedlings were the highest in seedlings grown under red light, compared to seedlings grown under white light (0.553 ± 0.048 and 0.028 ± 0.004, respectively). However, rutin production was higher under white (0.308 mg g-1 of dry weight) and blue lights (0.298 mg g-1 of dry weight). Thus, red light induces plant growth and increases leaf number and dry weight in in vitro-cultivated H. marrubioides, whereas blue and white lights promote the greatest rutin accumulation.

https://doi.org/10.1016/j.bjp.2016.12.004 883 downloads

13.

Antibacterial activity of (-)-cubebin isolated from Piper cubeba and its semisynthetic derivatives against microorganisms that cause endodontic infections
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Rezende, Karen C.S.

; Lucarini, Rodrigo

; Símaro, Guilherme V.

; Pauletti, Patricia M.

; Januário, Ana H.

; Esperandim, Viviane R.

; Martins, Carlos H.G.

; Silva, Mislaine A.

; Cunha, Wilson R.

; Bastos, Jairo K.

; Silva, Márcio L.A.E.

Revista Brasileira de Farmacognosia

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jun 2016, Volume 26 N. 3 Pages 296 - 303

Abstract: En | Text: En | PDF: En

Abstract Recent publications have highlighted the numerous biological activities attributed to the lignan (-)-cubebin (1), Piper cubeba L. f., Piperaceae, and ongoing studies have focused on its structural optimization, in order to obtain derivatives with greater pharmacological potential. The aim of this study was the obtainment of (1), its semisynthetic derivatives and evaluation of antibacterial activity. The extract of the seeds of P. cubeba was chromatographed, subjected to recrystallization and was analyzed by HPLC and spectrometric techniques. It was used for the synthesis of: (-)-O-methylcubebin (2), (-)-O-benzylcubebin (3), (-)-O-acetylcubebin (4), (-)-O-(N, N-dimethylamino-ethyl)-cubebin (5), (-)-hinokinin (6) and (-)-6.6'-dinitrohinokinin (7). The evaluation of the antibacterial activity has been done by broth microdilution technique for determination of the minimum inhibitory concentration and the minimum bactericidal concentration against Porphyromonas gingivalis, Prevotella nigrescens, Actinomyces naeslundii, Bacteroides fragilis and Fusobacterium nucleatum. It was possible to make an analysis regarding the relationship between structure and antimicrobial activity of derivatives against microorganisms that cause endodontic infections. The most promising were minimum inhibitory concentration =50 µg/ml against P. gingivalis by (2) and (3), and minimum inhibitory concentration =100 µg/ml against B. fragilis by (6). Cytotoxicity assays demonstrated that (1) and its derivatives do not display toxicity.

https://doi.org/10.1016/j.bjp.2015.12.006 1311 downloads

14.

Antibacterial evaluation of Styrax pohlii and isolated compounds
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Bertanha, Camila Spereta

; Utrera, Susane Hellen

; Gimenez, Valéria Maria Melleiro

; Groppo, Milton

; Silva, Márcio Luis Andrade e

; Cunha, Wilson Roberto

; Martins, Carlos Henrique Gomes

; Januário, Ana Helena

; Pauletti, Patrícia Mendonça

Brazilian Journal of Pharmaceutical Sciences

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dec 2013, Volume 49 N. 4 Pages 653 - 658

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

As atividades antimicrobianas das substâncias egonol (1) e homoegonol (2), do extrato etanólico das partes aéreas de Styrax pohlii (Styracaceae) (EE), bem como das frações n-hexano (HF), AcOEt (EF), n-BuOH (BF) e hidrometanólica (HMF) foram avaliadas frente aos seguintes microorganismos: Streptococcus pneumoniae (ATCC 6305), S. pyogenes (ATCC 19615), Haemophilus influenzae (ATCC 10211), Pseudomonas aeruginosa (ATCC 27853) e Klebsiella pneumoniae (ATCC 10031). O método de microdiluição em caldo foi utilizado para a determinação da concentração inibitória mínima (CIM) na avaliação preliminar da atividade antimicrobiana. EE mostrou valores de CIM de 400 µg/mL para S. pneumoniae e P. aeruginosa, e 300 µg/mL para H. influenzae. As frações HF e EF apresentaram melhora na atividade antimicrobiana, com valores de CIM de 200 µg/mL frente S. pneumoniae, mas apenas EF apresentou ação contra H. influenzae (200 µg/mL). Em relação às substâncias 1 e 2, o melhor valor de CIM (400 µg/mL) foi obtido por 1 frente a S. pneumoniae e P. aeruginosa, que exibiu fraca atividade antimicrobiana contra estas cepas padrões.

The antibacterial activity of the compounds egonol (1) and homoegonol (2), of the crude ethanolic extract of Styrax pohlii (Styracaceae) aerial parts (EE), and of its n-hexane (HF), EtOAc (EF), n-BuOH (BF), and hydromethanolic (HMF) fractions was evaluated against the following microorganisms: Streptococcus pneumoniae (ATCC 6305), S. pyogenes (ATCC 19615), Haemophilus influenzae (ATCC 10211), Pseudomonas aeruginosa (ATCC 27853), and Klebsiella pneumoniae (ATCC 10031). The broth microdilution method was used for determination of the minimum inhibitory concentration (MIC) during preliminary evaluation of antibacterial activity. The EE yielded MIC values of 400 µg/mL for S. pneumoniae and P. aeruginosa and 300 µg/mL for H. influenzae. The HF and EF fractions exhibited enhanced antibacterial activity, with MIC values of 200 µg/mL against S. pneumoniae, but only EF displayed activity against H. influenzae (MIC 200 µg/mL). The best MIC value with compounds 1 and 2 (400 µg/mL) was obtained for (1) against S. pneumoniae and P. aeruginosa. Therefore, 1 exhibited weak antibacterial activity against these standard strains.

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15.

Metabolic response induced by endophytic fungi and bacteria in H. marrubioides Epling in vitro microplants
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Vitorino, Luciana Cristina

; Silva, Fabiano Guimarães

; Lima, William Cardoso

; Soares, Marcos Antônio

; Pedroso, Rita Cássia Nascimento

; Silva, Marolí Rodrigues

; Dias, Herbert Júnior

; Crotti, Antônio Eduardo Miller

; Silva, Márcio Luís Andrade e

; Cunha, Wilson Roberto

; Pauletti, Patrícia Mendonça

; Januário, Ana Helena

Química Nova

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2013, Volume 36 N. 7 Pages 1014 - 1020

Abstract: En | Text: En | PDF: En

Hyptis marrubioides Epling is a native plant from Brazilian Cerrado. In this paper, the response of in vitro microplants of this species to inoculation with bacterial and fungal endophytic isolates is evaluated. HPLC-DAD analysis showed the presence of 3,4-O-(Z)-dicaffeoylquinic acid and quercetin-7-O-glucoside as the main components. GC/MS analysis demonstrated that the sesquiterpenes τ-cadinol and caryophyllene oxide were only produced in microplants inoculated with endophytic bacteria, while methyl hexadecanoate, methyl heptadecanoate and methyl (Z,Z,Z) 9,12,15-octadecatrienoate and the triterpene methyl 3β-hydroxy-urs-12-en-28-oate were overexpressed only when the microplant was treated with endophytic fungi.

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