RESUMO: O objetivo deste trabalho foi descrever mapas corneanos e imagens tomográficas do segmento anterior de gatos jovens sem raça definida e compará-los com aqueles descritos em humanos. Foram analisados os exames de 13 gatos sem raça definida (25 olhos) com idade entre 18 e 48 meses. Os seguintes mapas fornecidos pelo Galilei G4 foram analisados qualitativamente: curvatura axial e instantânea, paquimetria, poder total da córnea e elevação “best fit sphere” (BFS) e “best fit toric asphere” (BFTA). Além disso, foram analisados valores de curvaturas axiais e instantâneas anterior e posterior, potência total da córnea e paquimetria, além de imagens tomográficas do segmento anterior. Os mapas topográficos descrevem a região central da córnea dos gatos. Os mapas de curvatura axial anterior e posterior eram uniformemente planos. O mapa instantâneo da curvatura anterior era asférico. Um anel em formato semelhante a um donut foi observado no mapa de curvatura instantânea posterior. Nenhum padrão foi observado nos mapas de elevação. Os mapas de potência total da córnea tenderam à monofocalidade e 11 mapas apresentaram um triângulo multifocal regressivo na região inferior. O mapa de paquimetria foi uniforme e a paquimetria entre as zonas corneanas não diferiu estatisticamente. A câmara anterior era profunda com amplo ângulo que se estreita próximo à periferia; as superfícies anterior e posterior da córnea e a superfície anterior do cristalino tendiam a ser paralelas. Os mapas corneanos e as imagens tomográficas do segmento anterior de gatos jovens sem raça definida diferiram daqueles descritos em humanos. Foi observado o centro da córnea do gato mais plano esférico, uniformemente espesso e com tendência à monofocalidade. As superfícies anterior e posterior da córnea e a superfície anterior do cristalino tenderam a ser paralelas. RESUMO comparálos compará los humanos 1 25 (2 olhos 4 meses G qualitativamente best sphere BFS (BFS asphere BFTA. BFTA . (BFTA) disso planos asférico inferior estatisticamente periferia paralelas esférico 2 ( (BFTA

ABSTRACT: This research described corneal maps and anterior-segment tomographic images of young mixed breed cats and compared them to those described in humans. The exams of 13 mixed-breed cats (25 eyes) aged between 18 and 48 months were analyzed. The following maps provided by the Galilei G4 were analyzed qualitatively: axial and instantaneous curvature, pachymetry, total corneal power and best fit sphere (BFS) and best fit toric asphere (BFTA) elevation. Furthermore, anterior and posterior axial and instantaneous curvatures, total corneal power and pachymetry values were analyzed in addition to anterior segment tomography images. The topography maps described the central region of the cats’ cornea. Anterior and posterior axial curvature maps were uniformly flat. Instantaneous anterior curvature map was aspheric. A ring in a shape similar to a donut was observed in the posterior instantaneous curvature map. No patterns were observed in the elevation maps. Total corneal power maps tended to monofocality and eleven maps presented a regressive multifocal triangle in the inferior region. The pachymetry map was uniform and pachymetry among the corneal zones did not differ statistically. The anterior chamber was deep with a wide angle that narrows close to the periphery; the anterior and posterior corneal surfaces and the anterior surface of the lens tended to be parallel. Young mixed breed cats’ corneal maps and anterior segment tomographic images differed from those described in humans. The center of the cat’s cornea was flatter, spherical, uniformly thick and tended to monofocality. Anterior and posterior corneal surfaces and the anterior surface of the lens tended to be parallel. ABSTRACT anteriorsegment humans 1 mixedbreed 25 (2 eyes 4 G qualitatively BFS (BFS BFTA (BFTA Furthermore curvatures flat aspheric statistically periphery parallel cat s flatter spherical 2 (

RESUMO Objetivo: Recentemente, o ácido hialurônico foi proposto como promissor no tratamento do ectrópio cicatricial adquirido da pálpebra inferior. No entanto, não foram feitas avaliações quantitativas para confirmar este efeito, motivo que levou a realização do presente estudo que visou avaliar o efeito do ácido hialurônico no tratamento do ectrópio cicatricial adquirido da pálpebra inferior. Métodos: Oito portadores de ectrópio cicatricial adquirido da pálpebra inferior (13 pálpebras) foram tratados com uma única dose de 1 mL de ácido hialurônico, injetada na área pré-septal da pálpebra inferior. Os sintomas e o exame biomicroscópico foram realizados antes e 30 dias após a injeção do ácido hialurônico. A análise quantitativa da posição palpebral inferior (com e sem tração palpebral) foi determinada antes e 30 dias após a injeção do ácido hialurônico por meio de fotografias que foram analisadas usando o programa ImageJ. Resultados: Todos os pacientes apresentaram melhora parcial dos sintomas. A posição da pálpebra inferior foi elevada significativamente após a injeção do ácido hialurônico, com redução significativa dos ângulos medial e lateral, da distância entre o reflexo pupilar e a margem da pálpebra inferior, da área de fissura palpebral total e da área medial. No entanto, sinais de inflamação da margem palpebral e ceratite puntata da córnea persistiram. Conclusões: O ácido hialurônico injetado na área pré-septal da pálpebra inferior, melhorou os sintomas do ectrópio cicatricial adquirido da pálpebra inferior e elevou significativamente a posição da pálpebra inferior. Estudos com maior número de participantes e período de acompanhamento mais longo são necessários para melhor determinar os efeitos das injeções de ácido hialurônico a longo prazo no tratamento do ectrópio cicatricial adquirido da pálpebra inferior. Objetivo Recentemente entanto Métodos 13 (1 pálpebras préseptal pré septal 3 ImageJ Resultados lateral persistiram Conclusões (

ABSTRACT Purpose: Recently, hyaluronic acid (HA) was proposed as a promising option for the treatment of acquired lower eyelid cicatricial ectropion. However, this effect was not confirmed by quantitative assessments. This study aimed to assess the effect of hyaluronic acid on the treatment of acquired lower eyelid cicatricial ectropion. Methods: Eight patients with acquired lower eyelid cicatricial ectropion (13 eyelids) were treated with a single 1 mL injection of hyaluronic acid in the preseptal area of the lower eyelid. Evaluation of symptoms and biomicroscopic exam was performed before and 30 days after hyaluronic acid injection. Quantitative analysis of the lower eyelid position (with and without lid traction) was determined before and 30 days after hyaluronic acid injection through standard photographs analyzed using the ImageJ. Results: All patients experienced partial improvement of symptoms. The lower eyelid position was significantly lifted after hyaluronic acid injection with a significant reduction of medial and lateral angles, reduction of the margin reflex distance, and total and medial ocular fissure area. However, signs of lid margin inflammation and corneal punctate keratitis persisted. Conclusions: Hyaluronic acid injected in the pre-septal area of the lower eyelid improved acquired lower eyelid cicatricial ectropion symptoms and significantly lifted the position of the lower eyelid. Further studies, with a large number of participants and a long-term follow-up period, are needed to better determine the permanency of the effects of hyaluronic acid injections on the treatment of acquired lower eyelid cicatricial ectropion. Purpose Recently HA (HA However assessments Methods 13 (1 eyelids 3 traction ImageJ Results angles distance persisted Conclusions pre septal studies longterm long term followup follow up period (

RESUMO Os grandes saltos são passos que exigem potência muscular e coordenação motora. Visto que há uma escassez na literatura sobre o aprendizado e treinamento destes passos, o objetivo deste estudo foi verificar o efeito de doze semanas de aulas de ballet clássico com o exercício de grand allegro sobre a potência de membros inferiores em bailarinas amadoras. Participaram sete bailarinas, com 11,33±1,02 anos de idade, que cursavam o Grade 3 da Royal Academy of Dance. Foram realizados cálculos de Pico de Velocidade de Crescimento, testes de salto vertical e avaliação técnica do grand allegro em quatro momentos durante doze semanas. Os planos de aula, Percepção Subjetiva de Esforço e Qualidade Total de Recuperação de cada aula foram analisadas. Os principais resultados apontam bailarinas pré-púberes, cuja potência muscular e técnica do exercício de grand allegro apresentaram melhora (p<0,05). A carga semanal e quantidade de saltos e de exercícios executados variaram durante o período, enquanto que a Qualidade Total de Recuperação se mostrou estável. Os dados obtidos apontam para as variações da carga de trabalho nas aulas de ballet somadas à fase sensível do desenvolvimento e coordenação motora como os responsáveis pela evolução na potência muscular e na qualidade técnica. amadoras 1133102 11 33 1 02 11,33±1,0 idade Dance Crescimento analisadas prépúberes, prépúberes pré púberes, púberes pré-púberes p<0,05. p005 p p<0,05 . 0 05 (p<0,05) período estável 113310 11,33±1, p00 p<0,0 (p<0,05 11331 11,33±1 p0 p<0, (p<0,0 1133 11,33± p<0 (p<0, 113 11,33 p< (p<0 11,3 (p< 11, (p

ABSTRACT The big jumps are steps that require muscular power and motor coordination. Since there is a lack in the literature on the learning and training of these steps, the aim of this study was to verify the effect of 12 weeks of classical ballet classes with the grand allegro exercise on lower limb power in amateur ballerinas. Seven dancers, aged 11.33±1.02 years, who were studying Grade 3 of Royal Academy of Dance, participated Height Growth Speed Peak calculations, vertical jump tests, and technical evaluation of the grand allegro exercise were performed at four moments over the 12-week study period. Lesson plans, the Rating of Perceived Exertion, and the Total Recovery Quality for each class were collected to analyze load and recovery. The main results indicate that the dancers were prepubertal and lower limb muscular power and the technique of the grand allegro exercise improved (p<0.05). Weekly load and the quantity of jumps and exercises performed varied during the period, while Total Recovery Quality remained stable. The obtained data point to variations in the workload during ballet classes, combined with the sensitive phase of development and motor coordination, as responsible for the improvement in muscular power and technical quality. coordination 1 ballerinas 1133102 11 33 02 11.33±1.0 years Dance calculations tests 12week week period plans Exertion recovery p<0.05. p005 p p<0.05 . 0 05 (p<0.05) stable quality 113310 11.33±1. p00 p<0.0 (p<0.05 11331 11.33±1 p0 p<0. (p<0.0 1133 11.33± p<0 (p<0. 113 11.33 p< (p<0 11.3 (p< 11. (p

Abstract Background Cutaneous melanoma is a neoplasm with a high mortality rate and risk of metastases to distant organs. The Breslow micrometric measurement is considered the most important factor for evaluating prognosis and management, measured from the granular layer to the deepest portion of the neoplasm. Despite its widespread use, the Breslow thickness measurement has some inaccuracies, such as not considering variations in the thickness of the epidermis in different body locations or when there is ulceration. Objective To evaluate the applicability of a modified Breslow measurement, measured from the basal membrane instead of from the granular layer, in an attempt to predict sentinel lymph node examination outcome and survival of patients with melanoma. Methods A retrospective and cross-sectional analysis was carried out based on the evaluation of slides stained with hematoxylin & eosin from 275 cases of melanoma that underwent sentinel lymph node biopsy from 2008 to 2021 at a reference center in Brazil. Results Analysis of the Cox model to evaluate the impact of the Breslow measurement and the modified Breslow measurement on survival showed that both methods are statistically significant. Logistic regression revealed a significant association between both measurements and the presence of metastasis in sentinel lymph nodes. Conclusion Measuring melanoma depth from the basal membrane (modified Breslow measurement) is capable of predicting survival time and sentinel lymph node outcome, as well as the conventional Breslow measurement. organs management use inaccuracies ulceration crosssectional cross sectional 27 200 202 Brazil nodes 2 20

RESUMO Objetivo: Avaliar os resultados visuais, satisfação e qualidade de vida de pacientes atendidos em um hospital escola pelo Sistema Único de Saúde, submetidos a implante bilateral de lente intraocular multifocal difrativa. Métodos: Estudo tipo série de casos com intervenção, incluindo 20 pacientes submetidos a implante bilateral da lente intraocular multifocal difrativa EyeDiff® (Eyeol UK, Dunstable, UK). Os critérios de exclusão foram astigmatismo corneano >1,5 dioptria cilíndrica, cirurgia ou doença ocular prévias e complicações intraoperatórias ou pós-operatórias. Os pacientes foram avaliados após 1, 3 e 6 meses da cirurgia. Foram avaliadas a acuidade visual monocular e binocular para longe, intermediário e perto sob condições fotópica e mesópica, sensibilidade ao contraste monocular sob condições fotópicas, curva de defocus e questionário para avaliação da qualidade de vida. Resultados: A acuidade visual para longe corrigida monocular foi de 0,3 logMAR ou melhor e a acuidade visual para perto com correção para longe foi J3 ou melhor em todos os olhos, sob condições fotópicas. A acuidade visual binocular para perto com a correção para longe foi J1 em todos os casos. A sensibilidade ao contraste estava no nível mínimo de normalidade para frequências espaciais baixas e altas e abaixo dos limites normais para frequência espacial intermediária. O questionário de qualidade de vida mostrou que os pacientes apresentavam altos níveis de satisfação. Conclusão: O implante bilateral da lente intraocular multifocal EyeDiff® proporcionou boa acuidade visual e qualidade de vida, e independência de óculos aos pacientes. A acuidade visual e a sensibilidade ao contraste melhoraram progressivamente entre um e seis meses de pós-operatório. Objetivo visuais Saúde Métodos intervenção 2 EyeDiff Eyeol UK Dunstable UK. . UK) 15 1 5 >1, cilíndrica pósoperatórias. pósoperatórias pós operatórias. operatórias pós-operatórias mesópica fotópicas Resultados 03 0 0, J olhos intermediária Conclusão pósoperatório. pósoperatório operatório. operatório pós-operatório >1 >

ABSTRACT Purpose: To evaluate visual outcomes, satisfaction, and quality of life of patients assisted in a Medical School hospital by the Brazilian Public Health System, who underwent bilateral diffractive multifocal intraocular lens implantation. Methods: Case series study with intervention, including 20 patients who underwent bilateral implantation of multifocal IOL EyeDiff® (Eyeol UK, Dunstable, UK). Exclusion criteria were corneal astigmatism >1.5 cylindrical diopters, previous ocular surgery or ocular disease, and intra- or postoperative complications. Patients were evaluated one, three, and six months after surgery. Monocular and binocular visual acuity for distance, intermediate and near, under photopic and mesopic conditions, monocular contrast sensitivity under photopic conditions, defocus curve, and quality of life were assessed. Results: Monocular distance-corrected visual acuity was 0.3 logMAR or better and monocular distance-corrected near visual acuity was J3 or better in all eyes under photopic conditions. Binocular distance-corrected near visual acuity was J1 in all cases. Contrast sensitivity was at the minimum level of normality for low and high spatial frequencies and within normal limits for intermediate spatial frequency. The quality of life questionnaire showed a high level of patient satisfaction. Conclusion: Bilateral implantation of the multifocal intraocular lens EyeDiff® provides patients with good visual acuity and quality of life, besides spectacle independence. The visual acuity and contrast sensitivity progressively improved between one and six postoperative months. Purpose outcomes satisfaction System Methods intervention 2 EyeDiff Eyeol UK Dunstable UK. . UK) 15 1 5 >1. diopters disease intra complications three distance conditions curve assessed Results distancecorrected corrected 03 0 3 0. J cases frequency Conclusion independence >1 >

Abstract Background: Children and adolescents should be encouraged to participate in sports; however, physicians should screen for cardiac abnormalities that can lead to sudden death. The European Society of Cardiology, the Brazilian Society of Cardiology and the Brazilian Society of Sports Medicine indicate performing an electrocardiogram (ECG) in evaluating athletes, while the American Heart Association indicates complementary exams only when there is a personal or family history of cardiovascular diseases or changes in clinical examination. Objectives: To evaluate the need for an ECG in evaluating children and adolescents before starting physical activities. Methods: We recruited 983 children and adolescents who practiced physical activities for anthropometric assessment, clinical examination and conventional ECG at rest. Variables were analysed using the Goodman test with a significance level of 5%. Results: Participants had a higher incidence of overweight, obesity and severe obesity compared to standard World Health Organization (WHO) values. The most common finding in clinical examination was heart murmur (18.5% of participants). Electrocardiographic changes were found in 3.3% of participants, including paroxysmal supraventricular tachycardia and pre-excitation syndrome, which may be responsible for sudden death, even in asymptomatic individuals with no personal or family history of heart disease and no abnormality on clinical examination. Conclusions: ECG revealed arrhythmias that were not detected by clinical examination and may precede sudden death in individuals subjected to physical exertion, indicating its role in the assessment of children and adolescents before starting regular physical exercise. Background sports however (ECG athletes Objectives Methods 98 rest 5 5% Results overweight WHO (WHO values 18.5% 185 18 (18.5 participants. participants . participants) 33 3 3.3 preexcitation pre excitation syndrome Conclusions exertion exercise 9 18.5 1 (18. 3. 18. (18 (1 (

ABSTRACT Introduction: Kaposi sarcoma is a multifocal malignant neoplasm of endothelial cells which presents with characteristic lesions on the skin, mouth and lymph glands. Objective: Describe a case of Kaposi sarcoma with characteristics that hindered HIV infection diagnosis. Case presentation: A case is presented of a male 30-year-old patient recently diagnosed with acquired immunodeficiency syndrome, and not following any treatment. The patient was referred to the maxillofacial surgery service for right cervical adenopathy biopsy. Physical examination revealed generalized edema in both lower limbs, with hyperpigmented lesions of macular and papular appearance and various shades of color. A purplish pigmented lesion was detected in the hard palate mucosa. The lesion covered the palatal midline and extended toward the left hemiarch. Exeresis of the adenopathy was performed for diagnostic purposes, confirming the diagnosis of Kaposi sarcoma. Conclusions: Lack of familiarity with the clinical characteristics of Kaposi sarcoma, and not performing a biopsy of the skin lesions and a complete examination of the oral cavity, made the neoplasm go unnoticed to routine medical tests, leading to low suspicion of HIV/AIDS infection and delaying timely treatment. In advanced immunosuppression, Kaposi sarcoma related to acquired immunodeficiency syndrome tends to be more aggressive.

RESUMEN Introducción: El sarcoma de Kaposi es una neoplasia maligna multifocal de células endoteliales, que se presenta con lesiones características en la piel, boca y ganglios linfáticos. Objetivo: Describir un caso de sarcoma de Kaposi que, por sus características, entorpeció el diagnóstico de infección por VIH. Presentación del caso: Paciente masculino, de 30 años, diagnosticado recientemente con síndrome de inmunodeficiencia adquirida, sin tratamiento. Fue referido a la consulta de cirugía maxilofacial para biopsia de adenopatía cervical derecha. Durante el examen físico se observó edema generalizado en ambos miembros inferiores, con lesiones hiperpigmentadas de aspecto macular y papular de varias tonalidades. En la mucosa del paladar duro se apreció una lesión pigmentada violácea, que abarcaba la línea media palatina y se extendía hacia la hemiarcada izquierda. Se realizó la exégesis de la adenopatía con fines diagnósticos, con lo cual se confirmó sarcoma de Kaposi. Conclusiones: La falta de familiaridad con las características clínicas, así como la falta de una biopsia de las lesiones cutánea y un examen completo de la cavidad oral, ocasionaron que esta neoplasia pasara desapercibida en los exámenes médicos de rutina en el caso presentado, lo que condujo a un bajo índice de sospecha de la infección por VIH/sida y retrasó el tratamiento oportuno. Cuando la inmunosupresión está avanzada, el sarcoma de Kaposi relacionado al síndrome de inmunodeficiencia adquirida tiende a ser más agresivo.

RESUMO Objetivo: Avaliar os resultados visuais, satisfação e qualidade de vida de pacientes atendidos em um hospital escola pelo Sistema Único de Saúde, submetidos a implante bilateral de lente intraocular multifocal difrativa. Métodos: Estudo tipo série de casos com intervenção, incluindo 20 pacientes submetidos a implante bilateral da lente intraocular multifocal difrativa EyeDiff® (Eyeol UK, Dunstable, UK). Os critérios de exclusão foram astigmatismo corneano >1,5 dioptria cilíndrica, cirurgia ou doença ocular prévias e complicações intraoperatórias ou pós-operatórias. Os pacientes foram avaliados após 1, 3 e 6 meses da cirurgia. Foram avaliadas a acuidade visual monocular e binocular para longe, intermediário e perto sob condições fotópica e mesópica, sensibilidade ao contraste monocular sob condições fotópicas, curva de defocus e questionário para avaliação da qualidade de vida. Resultados: A acuidade visual para longe corrigida monocular foi de 0,3 logMAR ou melhor e a acuidade visual para perto com correção para longe foi J3 ou melhor em todos os olhos, sob condições fotópicas. A acuidade visual binocular para perto com a correção para longe foi J1 em todos os casos. A sensibilidade ao contraste estava no nível mínimo de normalidade para frequências espaciais baixas e altas e abaixo dos limites normais para frequência espacial intermediária. O questionário de qualidade de vida mostrou que os pacientes apresentavam altos níveis de satisfação. Conclusão: O implante bilateral da lente intraocular multifocal EyeDiff® proporcionou boa acuidade visual e qualidade de vida, e independência de óculos aos pacientes. A acuidade visual e a sensibilidade ao contraste melhoraram progressivamente entre um e seis meses de pós-operatório.

ABSTRACT Purpose: To evaluate visual outcomes, satisfaction, and quality of life of patients assisted in a Medical School hospital by the Brazilian Public Health System, who underwent bilateral diffractive multifocal intraocular lens implantation. Methods: Case series study with intervention, including 20 patients who underwent bilateral implantation of multifocal IOL EyeDiff® (Eyeol UK, Dunstable, UK). Exclusion criteria were corneal astigmatism >1.5 cylindrical diopters, previous ocular surgery or ocular disease, and intra- or postoperative complications. Patients were evaluated one, three, and six months after surgery. Monocular and binocular visual acuity for distance, intermediate and near, under photopic and mesopic conditions, monocular contrast sensitivity under photopic conditions, defocus curve, and quality of life were assessed. Results: Monocular distance-corrected visual acuity was 0.3 logMAR or better and monocular distance-corrected near visual acuity was J3 or better in all eyes under photopic conditions. Binocular distance-corrected near visual acuity was J1 in all cases. Contrast sensitivity was at the minimum level of normality for low and high spatial frequencies and within normal limits for intermediate spatial frequency. The quality of life questionnaire showed a high level of patient satisfaction. Conclusion: Bilateral implantation of the multifocal intraocular lens EyeDiff® provides patients with good visual acuity and quality of life, besides spectacle independence. The visual acuity and contrast sensitivity progressively improved between one and six postoperative months.

ABSTRACT Petri disease is a problem for vineyard caused mainly by the fungus Phaeomoniella chlamydospora. Contaminated seedlings are source of inoculum for the disease. Treatment to disinfect vine rootstock cuttings for seedling production is hot water treatment (HWT) by 50 °C for 30 min, but the efficiency is contested. To improve its efficacy, the study aimed to assess the combination of the following methods and the reason for the control: i) exposition of the fungus to five different temperatures in HWT bath for 30 min; ii and iii) exposition of the fungus and also plants infected with P. chlamydospora to different disinfection treatments (biofumigation = soil + cabbage at 40 °C; temperatures of 40 and 23 °C, all in microcosm), in different periods (7, 14 and 21 days), with and without additional HWT (51 °C for 30 min). The results showed that HWT with high temperatures (55–70 °C) for 30 min inactivated the fungus. Biofumigation technique at 40 °C and the temperature solely of 40 °C applied for up to 21 days and combined with HWT (51 °C for 30 min) inhibited mycelial growth and inactivated the fungus in vine plant tissues without compromising the rooting.

Abstract Background: As some individuals present resistance to obesity development, experiments have been trying to understand their susceptibility to cardiometabolic diseases. Objetive: To evaluate if the cardiac remodeling was related to collagen protein expression change. Methods: Male Wistar rats were randomized into two experimental groups: control diet (CD, n=15) or high-fat diet (HFD, n=15) for 30 weeks. Rats fed with HFD were ranked based on their adiposity indexes and classified as obese (Ob, n = 8) or obesity-resistant (ROb, n = 6). Rats that failed to present the normal characteristic of the control group while fed with CD were excluded (Control, n = 8). Nutritional profile, comorbidities (dyslipidemia, hypertension, glucose metabolism, hyperleptinemia), cardiac remodeling, and collagen protein expression were evaluated. The groups were compared by One-Way ANOVA, together the Tukey post hoc test, with p<0.05 considered significant. Results: The Ob rats presented an increased adiposity index when compared to C and ROb. Both groups Ob and ROb presented increased low-density lipoprotein (LDL), insulin, homeostatic model assessment of insulin resistance (HOMA- IR) and systolic blood pressure (SBP), and low high-density lipoprotein (HDL) levels when compared to the control group. The levels of triglycerides, non-esterified fatty acid (NEFA), and leptin were lower in ROb as compared to Ob, but higher than the control group. The Ob and ROb groups presented cardiac remodeling, evidenced by echocardiographic and post-mortem analysis. The collagen protein expression did not differ among the groups. Conclusion: The ROb animals present cardiac remodeling that is not related to collagen type I and III protein expression change. Background development diseases Objetive change Methods CD, (CD n=15 n15 15 highfat high fat HFD, (HFD 3 weeks (Ob 8 obesityresistant resistant ROb, (ROb 6. 6 . 6) Control, Control (Control 8. profile dyslipidemia, dyslipidemia (dyslipidemia hypertension metabolism hyperleptinemia, hyperleptinemia , hyperleptinemia) evaluated OneWay One Way ANOVA test p005 p 0 05 p<0.0 significant Results lowdensity density LDL, LDL (LDL) HOMA (HOMA IR SBP, SBP (SBP) highdensity HDL (HDL triglycerides nonesterified non esterified NEFA, NEFA (NEFA) postmortem mortem analysis Conclusion n=1 n1 1 p00 p<0. (LDL (SBP (NEFA n= p0 p<0 p<

RESUMO Objetivo: Avaliar as razões para não comparecimento à clínica oftalmológica da universidade após triagem oftalmológica realizada usando uma unidade móvel oftalmológica que fornece exame oftalmológico para comunidades não assistidas em uma região do Brasil. Métodos: Foi realizado um estudo observacional prospectivo no ano de 2017/2018 para avaliar as razões que fizeram com que os indivíduos triados usando uma unidade móvel oftalmológica e referenciados para a clínica oftalmológica da universidade não comparecessem à consulta agendada. A triagem foi feita em 10 municípios da região centro-oeste do estado de São Paulo, Brasil. Todos os 1.928 participantes fizeram o exame oftalmológico sem custo e 37,1% deles necessitaram de encaminhamento para a clínica oftalmológica da universidade para exames especializados ou cirurgias. O estudo usou duas ferramentas: (1) análise comparativa entre os dados dos indivíduos encaminhados que compareceram ao agendamento com os que não compareceram; (2) busca ativa dos indivíduos que não compareceram à consulta agendada, aplicando-se um questionário para avaliar os motivos para o não comparecimento. Resultados: Fatores como idade, sexo, distância entre a cidade de origem e o hospital universitário, número de oftalmologistas na cidade de procedência, renda familiar média e acuidade visual não influenciaram no comparecimento ao encaminhamento. Catarata foi a maior causa para o encaminhamento (350 casos). O não comparecimento foi maior nos portadores de glaucoma/glaucoma suspeitos (54,1%), estrabismo (45%) e afecções do segmento anterior (33,6%). Muitos indivíduos que não compareceram ao serviço de referência procuraram por outro local para o atendimento oftalmológico. Conclusão: O não comparecimento para tratamento oftalmológico sem custo depende de fatores relacionados ao paciente ou à falta de conhecimento das próprias condições oftalmológicas. Campanhas educativas nas comunidades assistidas devem ser feitas para alcançar maior comparecimento às consultas e melhor prevenir a cegueira evitável.

ABSTRACT Purpose: This study aimed to identify patient’s reason for no-show at a university eye clinic after ophthalmic examination via a mobile ophthalmic unit, which provides comprehensive ophthalmic care to underserved communities in a region of Brazil. Methods: In 2017/2018, this prospective observational study searched for no-shows at referrals to a university eye clinic after an outreach program screening via a mobile ophthalmic unit in 10 municipalities in the central-western region of São Paulo, Brazil. A total of 1,928 patients underwent a comprehensive eye examination at no cost, and 37.1% of them needed referral to a university eye clinic for specialized examinations or surgeries. We used the following two main tools: (1) comparative analysis between patients who attended the referral and those who did not; (2) active search using a questionnaire to assess reasons for no-show. Results: Attendance to referrals was not influenced by age, gender, distance from the university hospital, number of ophthalmologists in the municipality, average family income, and visual acuity. The main cause for referrals was cataract (350 cases). No-show was most common among glaucoma/suspected glaucoma (54.1%) cases, followed by strabismus (45%) and anterior segment disease (33.6%) cases. Many patients who did not attend the referral sought another service. Conclusion: Patient’s issues and lack of knowledge regarding their ophthalmic condition are the main reasons for no-show at referrals for free ophthalmic care. Thus, educational campaigns are needed to achieve consistently high attendance to prevent avoidable blindness.

Resumo Apresenta-se uma análise comparativa com base em dados médios mensais de precipitação acumulada e temperaturas máximas e mínimas registradas durante o período 2000-2019 pelas estações meteorológicas convencionais e automáticas existentes no Brasil. Foi avaliada a exatidão da localização das estações (coordenadas geográficas) fornecida pelo Instituto Nacional de Meteorologia (INMET), foi comparada gráfica e estatisticamente a informação fornecida por estações homônimas, foi correlacionada esta informação com variáveis independentes (elevação e latitude no caso das temperaturas e informação de satélite da Tropical Rainfall Measuring Mission -TRMM 3B43- no caso da precipitação), e foi avaliada a consistência da informação fornecida pelas estações comparada com os dados das cinco estações geograficamente mais próximas, através de interpolações espaciais baseadas em distancias inversas ponderadas sob um esquema de Jaccknife. Ainda que a informação fornecida ambos os tipos de estações podem ter boa concordância em muitos casos, existem incongruências que em alguns casos podem ser muito marcadas. Tais diferenças podem ser atribuídas tanto a erros sistemáticos como aleatórios, de origem indeterminada. Ambos conjuntos de dados tem problemas, mas a evidência avaliada sugere que as estações convencionais fornecem dados de precipitação um pouco mais confiáveis, enquanto que as automáticas são mais consistentes em relação a informação de temperaturas.

Abstract A comparative analysis is presented based, on one side, mean monthly accumulated precipitation and, on the other, maximum and minimum monthly mean temperatures, recorded during the period 2000-2019 by conventional and automatic weather stations existing in Brazil. The accuracy of the location of the stations (geographic coordinates) provided by the National Institute of Meteorology (INMET) was evaluated, comparing graphically and statistically the information provided by homonymous stations, this information was correlated with independent variables (elevation and latitude in the case of temperatures, and satellite information from the Tropical Rainfall Measuring Mission -TRMM 3B43-, in the case of precipitation), and evaluate the consistency of the information provided by the stations compared with data from the five stations geographically closest through spatial interpolations based on inverse-distance weighted under a Jaccknife scheme. Although the information provided by both types of stations may have good agreement in many cases, there are incongruities that in some cases can be very marked. Such differences can be attributed to both systematic and random errors, of indeterminate origin. Both data sets have problems, but the evidence evaluated suggests that conventional stations provide slightly more reliable precipitation data, while automatic ones are more consistent with regards to temperature information.

SUMMARY OBJECTIVE: First care providers working in the Brazilian Unified Health System are often physicians from the Family Health Program. Their knowledge on ophthalmology could indicate whether there is a need for training to decrease ophthalmological demands to secondary or tertiary health levels. METHODS: A cross-sectional observational study based on an electronic questionnaire was conducted to evaluate the ophthalmological knowledge of Family Health Program physicians working at the VI Regional Health Department, Sao Paulo, Brazil. All Family Health Program physicians from this regional health department were invited, and the study included those who responded to the full questionnaire (115 physicians). The data were evaluated using descriptive analysis. RESULTS: There was no difference in the ophthalmological knowledge between sexes or in relation to undergraduate schools. Only 20% of the interviewees were specialized in Family and Community Medicine, which did not influence the number of correct answers. Only 22 (19.1%) physicians reported having enough knowledge about the main eye disorders, and 82 (71.3%) physicians considered themselves capable of treating ophthalmological emergencies. However, acute glaucoma was recognized by only 51 (44.3%) physicians, and eye perforations could only be handled by 65 (56.5%) of them. In addition, only 47 (40.9%) participants correctly answered that congenital cataracts should be operated right after diagnosis. CONCLUSIONS: Family Health Program physicians working as first care providers in the Health System in Brazil presented poor ophthalmological knowledge. Providing training on ophthalmology may improve the ophthalmological care at the primary level within SUS and reduce the case demands at other healthcare levels.