Abstrato: As organizações devem chegar a acordo sobre os seus propósitos para estabelecer uma comunicação estratégica com os seus diferentes públicos, a fim de garantir a coerência e evitar riscos reputacionais devido a percepções de hipocrisia corporativa. Neste trabalho propomos caracterizar a hipocrisia corporativa como um conceito convergente entre as formas de comunicação estratégica do maior banco da Colômbia e seus usuários. Para isso, utilizamos uma metodologia mista composta por uma fase de análise exploratória quantitativa e uma segunda fase baseada em análise de conteúdo qualitativa. As principais conclusões mostram uma lacuna entre a comunicação do Banco e a forma como comunicam os utilizadores que mencionam o Banco, o que poderá estar a configurar um fenómeno de perceções de hipocrisia que a estratégia de comunicação do Banco deve considerar. 'A limitação do estudo é que é necessária mais do que a informação partilhada nas redes para deduzir as reais motivações do Banco ou como está a prestar os serviços prometidos, pelo que é essencial considerá-lo para pesquisas futuras.

Resumen: Las organizaciones deben acordar sus propósitos para establecer una comunicación estratégica con sus diferentes públicos para asegurar coherencia y evitar riesgos reputacionales por percepciones de hipocresía corporativa. En este trabajo nos proponemos caracterizar la hipocresía corporativa como un concepto convergente entre las formas de comunicación estratégica del banco más grande de Colombia y sus usuarios, usando una metodología mixta compuesta por una fase de análisis exploratorio cuantitativo y una segunda fase basada en análisis de contenido cualitativo. Los principales hallazgos muestran una brecha entre las comunicaciones del banco y la forma en la que se comunican los usuarios que lo mencionan, lo que podría estar configurando un fenómeno de percepciones de hipocresía que la estrategia comunicacional del banco debería considerar. La limitación del estudio es que se necesita más que la información compartida en redes para deducir las motivaciones reales del banco o cómo presta los servicios prometidos, por lo que es fundamental considerarlo en investigaciones futuras.

Abstract: Organizations need to agree on their objectives to build strategic communication with their target audiences to ensure coherence and avoid reputational risks due to the perception of corporate hypocrisy. In this work, we propose to characterize corporate hypocrisy as a convergent concept between the forms of strategic communication of the largest bank in Colombia and its users. To achieve this, we used a mixed methodology consisting of a quantitative exploratory analysis phase and a second phase based on qualitative content analysis. The main findings show a discrepancy between the bank's communication and the way users who mention the bank communicate. This could represent a phenomenon of perception of hypocrisy that the bank's communication strategy should consider. The limitation of the study is that more than the information shared on the networks is needed to deduce the bank's real motivations or the way it delivers the promised services, so this is essential to consider in future research.

ABSTRACT Introduction. This article provides an overview of the clinical practice guideline (CPG) for breast cancer screening in the Social Security of Peru (EsSalud). Objective. To offer evidence-based clinical recommendations for breast cancer screening within EsSalud. Methods. The CPG for breast cancer screening was developed by establishing a guideline development group (local GDG) consisting of medical specialists and methodologists. The local GDG formulated 5 clinical questions to be answered by this CPG. Systematic searches of systematic reviews and, when it was considered pertinent, primary studies were conducted in Pubmed and Cochrane CENTRAL during 2022. The evidence to answer each of the posed clinical questions was selected. The certainty of evidence was evaluated using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) methodology. In periodic work meetings, the local GDG used the GRADE methodology to review the evidence and formulate the recommendations, points of good clinical practice, and the flowchart of screening Finally, the CPG was approved with Resolution No. 68-IETSI-ESSALUD-2022. Results. The CPG examined 5 clinical questions related to physical examination and diagnostic imaging for breast cancer screening. This led to the development of 8 recommendations (2 strong and 6 conditional), 7 best practice points, and 1 flowchart. Conclusion. This article outlines the methodology and evidence-based findings of the CPG for breast cancer screening at EsSalud.

RESUMEN Introducción. Este artículo presenta un resumen de la guía de práctica clínica (GPC) para el tamizaje de cáncer de mama en el Seguro Social del Perú (EsSalud). Objetivo. Brindar recomendaciones clínicas fundamentadas en la evidencia para el tamizaje de cáncer de mama en EsSalud. Métodos. Se conformó un grupo elaborador de la guía (GEG) compuesto por especialistas médicos y metodólogos. El GEG formuló 5 preguntas clínicas a ser respondidas en esta GPC. Durante 2022, se realizaron búsquedas sistemáticas de revisiones sistemáticas y, cuando fue necesario, de estudios primarios en PubMed y Cochrane CENTRAL. La evidencia fue seleccionada para responder cada una de las preguntas. La certeza de la evidencia fue evaluada mediante la metodología Grading of Recommendations Assessment, Development, and Evaluation (GRADE). En reuniones periódicas, el GEG utilizó la metodología GRADE para revisar la evidencia y desarrollar las recomendaciones, puntos de buenas prácticas clínicas y el flujograma de tamizaje. La GPC fue aprobada mediante la Resolución N° 98-IETSI-ESSALUD-2022. Resultados. Esta GPC abordó 5 preguntas clínicas relacionadas con el examen físico y el uso de métodos de diagnóstico por imágenes para el tamizaje de cáncer de mama, resultando en la formulación de 8 recomendaciones (2 fuertes y 6 condicionales), 7 puntos de buenas prácticas clínicas, y un flujograma. Conclusión. Este artículo resume la metodología empleada y los hallazgos basados en evidencia de la GPC para el tamizaje de cáncer de mama en EsSalud.

ABSTRACT The livestock productive landscape encompassing Playada, La Piedad, San Francisco, and La Rafaela estates in the western region of Paraguay emerges as a representative model with capabilities for both production and conservation of ecosystem services. Through categorization using ArcGIS 10.3, it was identified that grasslands and savannas cover approximately 35% of the total area, around 5,716 hectares. The study, based on landscapescale homogeneity, allowed for the analysis of physical characteristics, distribution, coverage, and anthropogenic pressures in five Homogeneous Environmental Units (HEUs). The characterization of ecosystem services revealed that forest remnants provide regulation, provisioning, and cultural services, while grasslands are the primary providers of supporting services. Technical profiles were generated for each HEU, and conservation strategies such as agroforestry systems and land planning, derived from sustainable production, were proposed for the benefit of both producers and ecosystems, emphasizing the importance of understanding the dynamics of productive landscapes for resource optimization and long-term sustainability.

RESUMEN El paisaje productivo ganadero en las fincas Playada, La Piedad, San Francisco y La Rafaela, región occidental de Paraguay, se erige como modelo representativo con aptitudes para producción y conservación de servicios ecosistémicos. Mediante categorización con ArcGIS 10.3, se identificó que los pastizales y sabanas cubren aproximadamente el 35% del área total, alrededor de 5,716 hectáreas. El estudio, basado en homogeneidad a escala paisaje, permitió analizar características físicas, distribución, cobertura y presiones antrópicas en cinco Unidades Ambientales Homogéneas (UAH). La caracterización de servicios ecosistémicos reveló que los remanentes boscosos proveen servicios de regulación, provisión y culturales, mientras que los pastizales son los principales proveedores de servicios de soporte. Con fichas técnicas para cada UAH, se propusieron estrategias de conservación como sistemas silvopastoriles y planificación predial, derivadas de la producción sostenible, en beneficio de productores y ecosistemas, subrayando la importancia del conocimiento de la dinámica de paisajes productivos para la optimización de recursos y la sostenibilidad a largo plazo.

Resumen La uretroplastia se ha convertido en el estándar de manejo de la estrechez uretral, dependiendo de la localización y etiología de esta. Los datos de los resultados a largo plazo varían dependiendo de la definición que se utilice como éxito (subjetiva u objetiva). El objetivo de esta revisión integrativa es mostrar la información disponible sobre los resultados funcionales de pacientes con estrechez uretral manejados quirúrgicamente. El estudio es una revisión integrativa que se realizó mediante una búsqueda de la literatura en PubMed. Incluimos artículos que describían resultados de pacientes sometidos a reconstrucción uretral con uretroplastia, solo hombres, en inglés o español, publicados entre 1999-2022. Incluimos 34 artículos, los cuales mostraron que, según el tipo de procedimiento realizado, las características de la estrechez uretral y las variables definidas como éxito y fracaso, los factores de riesgo asociados a la recurrencia posterior a la reconstrucción con uretroplastia en uretra fueron la presencia de comorbilidades, obesidad y etiología infecciosa. Concluimos entonces que la uretroplastia es un procedimiento que ha aumentado en los últimos años, con pocos estudios que nos comparan resultados dependiendo del tipo de procedimiento utilizado. Nuestra revisión encontró que hay mayor literatura sobre el uso de injertos de mucosa oral comparado con escición primaria y anastomosis (EPA), con unos resultados anatómicos y funcionales comparables entre ambos procedimientos. Los cuestionarios PROMS (Patient Reported Outcome Measures) son herramientas útiles para el seguimiento postoperatorio de estos pacientes.

Abstract Urethroplasty has become the standard for managing urethral stricture, depending on its location and etiology. Long-term outcome data varies depending on the definition of success used (subjective or objective). The objective of this integrative review is to show the available information on the functional results of patients with surgically managed urethral stricture. The study is an integrative review that was carried out through a literature search in PubMed, we included articles that described the results of patients undergoing urethral reconstruction with urethroplasty, only men, in English or Spanish, published between 1999-2022. The study included 34 articles, which showed that, depending on the type of procedure performed, the characteristics of the urethral stricture and the variables defined as success and failure, the risk factors associated with recurrence after reconstruction with urethroplasty in the urethra were the presence of comorbidities, obesity, and infectious etiology. In conclusion, urethroplasty is a procedure that has increased in recent years, with few studies that compare results depending on the type of procedure used. Our review found that there is more literature on the use of buccal mucosa graft (BMG) compared to excision and primary anastomotic urethroplasy (EPA), with comparable anatomical and functional results between both procedures.

Abstract Forest pests are one of the primary disturbance factors in the temperate forests of Mexico. Ips confusus attacks Pinus cembroides trees, especially after intense droughts. The aim of this study was to assess the impact of I. confusus on the annual radial growth of a P. cembroides forest in the Carichí municipality, state of Chihuahua, México. Additionally, the influence of climatic variables was determined. Increment cores were extracted from both attacked (AA) and non-attacked P. cembroides trees (ANA). A total of 53 increment cores were dated, spanning from 1776 to 2012 (AA=24 and ANA=29). Starting from 1998, differential basal area growth was observed between AA and ANA. By the time of tree mortality in 2012, a difference of over 100 % was recorded (AA=8.03±1.53 cm2 year⁻¹, and ANA=17.7±1.74 cm2 year⁻¹, p<0.001). However, ANA exhibited greater sensitivity to climatic variables than AA, displaying increased synchrony in recent years. At the canopy level, a correlation was found between Normalized Difference Vegetation Index (NDVI, r=0.51, p<0.05) and ANA, exclusively. Nonetheless, AA demonstrated a high sensitivity to drought conditions, particularly with the Palmer Drought Severity Index (PDSI, r=0.53, p<0.05). This suggests that prior drought conditions (up to 10 years) are linked to reduced growth in P. cembroides, predisposing them to forest pest infestations.

Resumen Las plagas forestales representan una de las principales causas de disturbio en los bosques templados de México. Ips confusus ataca a Pinus cembroides después de intensas sequías. El objetivo del presente estudio fue evaluar tanto el impacto por I. confusus, como del clima en el crecimiento radial de un bosque de P. cembroides en el municipio Carichí, Chihuahua, México. Se obtuvieron núcleos de crecimiento de árboles atacados (AA) y de no atacados (ANA) de la misma especie. Se dataron 53 series dendrocronológicas con una extensión máxima de 1776 a 2012 (AA=24 y ANA=29). A partir de 1998, se observó un crecimiento diferencial en el área basal entre AA y ANA. Al momento de la muerte del arbolado (2012), se registró una diferencia de más de 100 % (AA=8.03±1.53 cm2 año-1, y ANA=17.7±1.74 cm2 año-1, p<0.001). Los ANA mostraron una sensibilidad superior a variables climáticas que los AA, con una mayor sincronía en los últimos años. A nivel dosel, se determinó una correlación con el Índice de Vegetación de Diferencia Normalizada (NDVI, r=0.51, p<0.05) exclusivamente para ANA. Sin embargo, los AA fueron más sensibles a condiciones de sequía, con base en el Índice de Severidad de Sequia de Palmer (PDSI, r=0.53, p<0.05). Esto sugiere que condiciones de sequía previas (hasta 10 años) predisponen menor crecimiento radial de P. cembroides y favorece el ataque de plagas.

RESUMEN Introducción: Dada la existencia de variadas guías para enfermedades respiratorias, se buscó conocer cuáles eligen los médicos para utilizar en su práctica clínica. Materiales y Métodos: se realizó un estudio descriptivo, transversal, mediante una encuesta a neumonólogos de la Asociación Argentina de Medicina Respiratoria. Resultados: La guía más utilizada para EPOC fue la Iniciativa Global para la Enfermedad Pulmonar Obstructiva Crónica (GOLD) (82 %), seguida por GesEPOC (51 %). Para asma las más usadas fueron la Iniciativa Global para el Asma (GINA) 2022 (89 %) y GEMA 5.2 (68 %). En asma de difícil control, se prefirieron GINA 2022 (82 %) y GEMA 2022 (53 %). En espirometría, un 54 % de los respondedores se inclinó por NHANES III y un 22 % utilizó valores teóricos de referencia de Knudson. En neumonía, el 62 % eligió SADI, el 37 %, IDSA y el 20 %, BTS. Para nódulos pulmonares, el 62 % prefirió las guías Fleischner, 35 % se inclinó por Lung-RADS 1.1. Para neumonitis por hipersensibilidad, un 83 % seleccionó las guías de las sociedades conjuntas ATS/JRS/ ALAT. Para imágenes de fibrosis pulmonar, el 89 % utilizó ALAT/ERS/JRS/ALAT y el 18 % White Paper. Discusión: si bien hay estudios sobre adherencia a guías, no los hay acerca de preferencias de utilización entre varias referidas a un mismo tema. En EPOC y asma (incluyendo la de difícil control) se eligieron GOLD y GINA y las de la Sociedad Española de Patología Respiratoria (GesEPOC y GEMA). El uso preferencial de la guía nacional para neumonía es coherente con la necesidad de contemplar la epidemiología local.

ABSTRACT Introduction: Since there are various guidelines for respiratory diseases, we aimed to know which are chosen by physicians in their daily clinical practice. Materials and Methods: A descriptive, cross-sectional study was conducted through a questionnaire sent to pulmonologists of the Argentinian Association of Respiratory Medicine. Results: The most commonly used guideline for COPD (chronic obstructive pulmonary disease) was the Global Initiative for Chronic Obstructive Lung Disease (GOLD) (82 %), followed by GesEPOC (51 %). For asthma, the most commonly used guideline was the Global Initiative for Asthma (GINA) 2022 (89 %) and the Spanish Guideline on the Management of Asthma (known for its acronym in Spanish, GEMA), GEMA 5.2 (68 %). In difficult-to-control asthma, GINA 2022 (82 %) and GEMA 2022 (53 %) were used. With regard to spirometries, 54 % of respondents favored NHANES III (Third National Health and Nutrition Examination Survey) and 22 % used theoretical Knudson reference values. For pneumonia, 62 % chose the guidelines of the SADI (Argentinian Society of Infectious Diseases), 37 % preferred those of the IDSA (Infectious Diseases Society of America) and 20 %, chose the guidelines of the BTS (British Thoracic Society). For pulmonary nodules, 62 % used Fleischner guidelines, and 35 % favored Lung-RADS 1.1. For hypersensitivity pneumonitis, 83 % selected the ATS/JRS/ALAT Guidelines (American Thoracic Society/Japanese Respiratory Society/Latin American Thoracic Society). And with respect to pulmonary fibrosis imaging, 89 % used ALAT/ERS (European Respiratory Society)/JRS recommendations, and 18 % preferred White Paper. Discussion: Although there are studies about adherence to guidelines, none of them shows which are the chosen recommendations within a group of guidelines of the same topic. In COPD and asthma (including difficult-to-control asthma) GOLD, GINA and the guidelines of the Spanish Society of Respiratory Disease (GesEPOC and GEMA) were chosen. The preference for the national guideline for pneumonia is consistent with the need to consider local epidemiology.

RESUMEN Introducción: Dada la existencia de variadas guías para enfermedades respiratorias, se buscó conocer cuáles eligen los médicos para utilizar en su práctica clínica. Materiales y Métodos: se realizó un estudio descriptivo, transversal, mediante una encuesta a neumonólogos de la Asociación Argentina de Medicina Respiratoria. Resultados: La guía más utilizada para EPOC fue la Iniciativa Global para la Enferme dad Pulmonar Obstructiva Crónica (GOLD) (82 %), seguida por GesEPOC (51 %). Para asma las más usadas fueron la Iniciativa Global para el Asma (GINA) 2022 (89 %) y GEMA 5.2 (68 %). En asma de difícil control, se prefirieron GINA 2022 (82 %) y GEMA 2022 (53 %). En espirometría, un 54 % de los respondedores se inclinó por NHANES III y un 22 % utilizó valores teóricos de referencia de Knudson. En neumonía, el 62 % eligió SADI, el 37 %, IDSA y el 20 %, BTS. Para nódulos pulmonares, el 62 % prefirió las guías Fleischner, 35 % se inclinó por Lung-RADS 1.1. Para neumonitis por hip ersensibilidad, un 83 % seleccionó las guías de las sociedades conjuntas ATS/JRS/ ALAT. Para imágenes de fibrosis pulmonar, el 89 % utilizó ALAT/ERS/JRS/ALAT y el 18 % White Paper. Discusión: si bien hay estudios sobre adherencia a guías, no los hay acerca de pref erencias de utilización entre varias referidas a un mismo tema. En EPOC y asma (in cluyendo la de difícil control) se eligieron GOLD y GINA y las de la Sociedad Española de Patología Respiratoria (GesEPOC y GEMA). El uso preferencial de la guía nacional para neumonía es coherente con la necesidad de contemplar la epidemiología local.

ABSTRACT Introduction: Since there are various guidelines for respiratory diseases, we aimed to know which are chosen by physicians in their daily clinical practice. Materials and Methods: A descriptive, cross-sectional study was conducted through a questionnaire sent to pulmonologists of the Argentinian Association of Respiratory Medicine. Results: The most commonly used guideline for COPD (chronic obstructive pulmonary disease) was the Global Initiative for Chronic Obstructive Lung Disease (GOLD) (82 %), followed by GesEPOC (51 %). For asthma, the most commonly used guideline was the Global Initiative for Asthma (GINA) 2022 (89 %) and the Spanish Guideline on the Management of Asthma (known for its acronym in Spanish, GEMA), GEMA 5.2 (68 %). In difficult-to-control asthma, GINA 2022 (82 %) and GEMA 2022 (53 %) were used. With regard to spirometries, 54 % of respondents favored NHANES III (Third National Health and Nutrition Examination Survey) and 22 % used theoretical Knudson reference values. For pneumonia, 62 % chose the guidelines of the SADI (Argentinian Society of Infectious Diseases), 37 % preferred those of the IDSA (Infectious Diseases Society of America) and 20 %, chose the guidelines of the BTS (British Thoracic Society). For pulmonary nodules, 62 % used Fleischner guidelines, and 35 % favored Lung-RADS 1.1. For hypersensitivity pneumonitis, 83 % selected the ATS/JRS/ALAT Guidelines (American Thoracic Society/Japanese Respiratory Society/Latin American Thoracic Society). And with respect to pulmonary fibrosis imaging, 89 % used ALAT/ERS (Eu ropean Respiratory Society)/JRS recommendations, and 18 % preferred White Paper. Discussion: Although there are studies about adherence to guidelines, none of them shows which are the chosen recommendations within a group of guidelines of the same topic. In COPD and asthma (including difficult-to-control asthma) GOLD, GINA and the guidelines of the Spanish Society of Respiratory Disease (GesEPOC and GEMA) were chosen. The preference for the national guideline for pneumonia is consistent with the need to consider local epidemiology.

Abstract The school-family interrelationship is a topic of great importance in the educational field and has been the subject of study, reflection and analysis throughout history, since this close link has proven to have a significant impact on the academic, social and emotional development of students, given in their academic performance, reduction of school dropout and the development of socio-educational skills. Accordingly, the research problem is stated as: How to improve the school-family interrelationship for the education of seventh grade students of the "Dr. Luis Felipe Zapater" school in the city of Loja? and as an objective the implementation of educational strategies to improve the school-family interrelationship in the education of seventh grade students of the "Dr. Luis Felipe Zapater" school in the city of Loja. Mixed research, of explanatory type, was applied. The research tools and techniques used were observation, document analysis, survey and interview. The population and the sample coincide, being 22 students, 22 parents, and 1 seventh grade teacher. The results obtained demonstrate the role of educational strategies in the improvement of the school-family interrelationship, since their applicability and effectiveness are evidenced if they are oriented to promote an active and effective participation of the family in the education of their children. The actuality is expressed in that it responds to the research line school-family-community interrelation, of the Research Project of the Master's Degree, entitled Didactic Management and Educational Quality in Basic Education.

Resumen La interrelación escuela-familia es un tema de gran importancia en el ámbito educativo y ha sido objeto de estudio, reflexión y análisis a lo largo de la historia, puesto que, este estrecho vínculo ha demostrado tener un impacto significativo en el desarrollo académico, social, y emocional de los estudiantes, dado en su desempeño académico, reducción de la deserción escolar y el desarrollo de habilidades socioeducativas. Acorde con esto, se declara el problema de investigación ¿Cómo perfeccionar la interrelación escuela-familia para la educación de los estudiantes de séptimo año de la escuela “Dr. Luis Felipe Zapater” de la ciudad de Loja? y como objetivo la implementación de estrategias educativas para perfeccionar la interrelación escuela-familia en la educación de los estudiantes de séptimo año de la escuela “Dr. Luis Felipe Zapater” de la ciudad de Loja. Se aplicó una investigación mixta, de tipo explicativa. Las herramientas y técnicas investigativas empleadas la observación, análisis de documentos, encuesta y entrevista. La población y la muestra coinciden, siendo 22 estudiantes, 22 padres de familia, 1 docente de séptimo año. Los resultados obtenidos demuestran el papel que cumplen las estrategias educativas en el perfeccionamiento de la interrelación escuela-familia, puesto que su aplicabilidad y efectividad se evidencian, si están orientadas a promover una participación activa y efectiva de la familia en la educación de sus hijos. La actualidad se expresa en que responde a la línea de investigación interrelación escuela-familia-comunidad, del Proyecto de Investigación de la Maestría, titulado Gestión Didáctica y Calidad educativa en la Educación Básica.

Abstract In design, typography takes on multimodal roles in constructing the message. Characterizing and understanding it required a two-phase investigation. In the first phase, with a quantitative approach, 171 texts present in 72 graphic pieces were analyzed, applying a matrix of theoretical variables related to typographic formalism, visual grammar, and content analysis. The initial results highlight typographic usage as a graphic, compositional, and aesthetic representation of the text. In the second phase, with a qualitative and hermeneutic interpretative approach, a controlled experiment was conducted regarding the degree of significance of typography. This experiment was applied in three Ecuadorian provinces with a higher concentration of voters. The quanti-qualitative results show that typography in Ecuadorian political propaganda assumed a functional and aesthetic rhetorical role, limited to being the graphic representation of language through text. It became disconnected from symbolic, historical, social, and cultural value in relation to the target group of the message.

Resumen En el diseño, la tipografía adquiere roles multimodales en la construcción del mensaje. Caracterizarla y comprenderla requirió de una investigación de dos fases. En la primera fase, con un enfoque cuantitativo, se analizaron 171 textos presentes en 72 piezas gráficas, aplicando una matriz de variables teóricas referentes al formalismo tipográfico, a la gramática visual y al análisis de contenidos. Los resultados iniciales destacan el uso tipográfico como representación gráfica, compositiva y estética del texto. En la segunda fase, de corte cualitativo e interpretativo hermenéutico, se realizó un experimento controlado referente al grado de significación de la tipografía, aplicado en tres provincias ecuatorianas de mayor concentración de electores. Los resultados cuanti-cualitativos muestran que la tipografía en la propaganda política ecuatoriana adquirió un rol retórico funcional y estético, limitándose a ser la representación gráfica del lenguaje a través del texto, y desconectándose del valor simbólico, histórico, social y cultural en relación con el grupo al que se dirige el mensaje.

ABSTRACT BACKGROUND: Loxosceles spp are arthropods found worldwide. Its bite may produce cutaneous loxoscelism (necrotic or edematous) or cutaneous-visceral loxoscelism. Depending on their severity and location, cutaneous forms are managed with local cold application and systemic administration of antihistamines, corticosteroids, antibiotics, polymorphonuclear inhibitors, and analgesics. OBJECTIVE: This study aimed to report a case of cutaneous loxoscelism and to identify the main dermatological manifestations associated with the Loxosceles spp bite. DESIGN AND SETTING: This case report and literature review was conducted in a Mexican university. METHODS: A detailed report on the medical management of a patient with cutaneous loxoscelism treated at the emergency department of a public hospital was published. Scopus, PubMed, Web of Science, and Google Scholar databases were searched to identify articles reporting cutaneous loxoscelism. The following keywords were used during the database search: “loxoscelism” OR “spider bite,” OR “loxosceles” OR “loxosceles species” OR “loxosceles venom” OR “loxoscelism case report” AND “cutaneous” OR “dermonecrotic arachnidism.” RESULTS: A 62-year-old female patient with cutaneous loxoscelism was treated with systemic dapsone and local heparin spray. Eighteen studies with 22 clinical cases were included in this systematic review. Of the 22 patients, 12 (54.5%) were men. L. rufescens was the predominant spider species. CONCLUSIONS: The administration of dapsone and heparin for the management of cutaneous loxoscelism demonstrated success in this case, with no sequelae observed. In general, the literature review indicated favorable outcomes in patients treated with antimicrobials and corticosteroids, with continuous healing of skin lesions. SYSTEMATIC REVIEW REGISTRATION: PROSPERO ID CRD42023422424 (https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023422424). BACKGROUND worldwide necrotic edematous cutaneousvisceral visceral location antihistamines corticosteroids antibiotics inhibitors analgesics OBJECTIVE SETTING university METHODS published Scopus PubMed Science search bite, loxosceles species venom “cutaneous dermonecrotic arachnidism. arachnidism RESULTS 62yearold yearold 62 year old spray 2 1 54.5% 545 54 5 (54.5% men L CONCLUSIONS observed general lesions REGISTRATION CRD CRD4202342242 https//www.crd.york.ac.uk/prospero/display_record.phpID=CRD42023422424. httpswwwcrdyorkacukprosperodisplayrecordphpIDCRD42023422424 httpswwwcrdyorkacukprosperodisplayrecordphpIDCRD https //www.crd.york.ac.uk/prospero/display_record.php ID=CRD42023422424 . www crd york ac uk prospero display record php (https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023422424) 6 54.5 (54.5 CRD420234224 phpID https//www.crd.york.ac.uk/prospero/display_record.phpID=CRD42023422424 httpswwwcrdyorkacukprosperodisplayrecordphpIDCRD4202342242 wwwcrdyorkacukprosperodisplayrecordphp IDCRD42023422424 IDCRD ID=CRD4202342242 (https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023422424 54. (54. CRD42023422 https//www.crd.york.ac.uk/prospero/display_record.phpID=CRD4202342242 httpswwwcrdyorkacukprosperodisplayrecordphpIDCRD420234224 IDCRD4202342242 ID=CRD420234224 (https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD4202342242 (54 CRD4202342 https//www.crd.york.ac.uk/prospero/display_record.phpID=CRD420234224 httpswwwcrdyorkacukprosperodisplayrecordphpIDCRD42023422 IDCRD420234224 ID=CRD42023422 (https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD420234224 (5 CRD420234 https//www.crd.york.ac.uk/prospero/display_record.phpID=CRD42023422 httpswwwcrdyorkacukprosperodisplayrecordphpIDCRD4202342 IDCRD42023422 ID=CRD4202342 (https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023422 ( CRD42023 https//www.crd.york.ac.uk/prospero/display_record.phpID=CRD4202342 httpswwwcrdyorkacukprosperodisplayrecordphpIDCRD420234 IDCRD4202342 ID=CRD420234 (https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD4202342 CRD4202 https//www.crd.york.ac.uk/prospero/display_record.phpID=CRD420234 httpswwwcrdyorkacukprosperodisplayrecordphpIDCRD42023 IDCRD420234 ID=CRD42023 (https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD420234 CRD420 https//www.crd.york.ac.uk/prospero/display_record.phpID=CRD42023 httpswwwcrdyorkacukprosperodisplayrecordphpIDCRD4202 IDCRD42023 ID=CRD4202 (https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023 CRD42 https//www.crd.york.ac.uk/prospero/display_record.phpID=CRD4202 httpswwwcrdyorkacukprosperodisplayrecordphpIDCRD420 IDCRD4202 ID=CRD420 (https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD4202 CRD4 https//www.crd.york.ac.uk/prospero/display_record.phpID=CRD420 httpswwwcrdyorkacukprosperodisplayrecordphpIDCRD42 IDCRD420 ID=CRD42 (https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD420 https//www.crd.york.ac.uk/prospero/display_record.phpID=CRD42 httpswwwcrdyorkacukprosperodisplayrecordphpIDCRD4 IDCRD42 ID=CRD4 (https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42 https//www.crd.york.ac.uk/prospero/display_record.phpID=CRD4 IDCRD4 ID=CRD (https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD4 https//www.crd.york.ac.uk/prospero/display_record.phpID=CRD (https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD

In this research, a meticulous screening process was conducted using four servers: Drug Target Explorer, Swiss Target Predictor, SEA Predictor, and Target Hunter. The primary objective was to identify a series of potential biological targets related to the regulation of cell growth and apoptosis in cancer cells using cinnamic acid derivatives. This study focused on five specific targets, matrix metallopeptidase 9 (MMP9), apoptosis inducing factor (AIF), aldo-keto reductase family 1 member C3 (AKR1C3), aldo-keto reductase family 1 member B10 (AKR1B10), mitogen-activated protein kinase 14 (MAPK14), all of which are well known to play a significant role in cancer cell dynamics. To explore both molecular recognition and molecular dynamics, a series of in silico investigations (docking and molecular dynamics) were carried out using a collection of 14 cinnamic acid derivatives, including cinnamic acid phenethyl ester (CAPE) as a notable reference molecule due to its widely recognized anticancer effects. Furthermore, preliminary in vitro data revealed a potentially promising cytotoxic effect of (E)-N-[(3,4-dichlorophenyl)methyl]-3-(4-phenoxyphenyl)-2-propenamide (LQM755) on a human gastric adenocarcinoma cell-line (AGS cells), which are characterized by the overexpression of the MMP9 protein. Therefore, the chemical compound LQM755 provides an initial perspective in the field of cancer therapy. research servers Explorer Predictor Hunter derivatives MMP9, MMP , (MMP9) AIF, AIF (AIF) aldoketo aldo keto C AKR1C3, AKR1C3 AKRC AKR (AKR1C3) B B1 AKR1B10, AKR1B10 AKRB (AKR1B10) mitogenactivated mitogen activated MAPK14, MAPK14 MAPK (MAPK14) dynamics docking CAPE (CAPE effects Furthermore EN3,4dichlorophenylmethyl34phenoxyphenyl2propenamide EN34dichlorophenylmethyl34phenoxyphenyl2propenamide ENdichlorophenylmethylphenoxyphenylpropenamide E N 3,4 dichlorophenyl methyl 3 4 phenoxyphenyl 2 propenamide LQM (LQM755 cellline line AGS cells, cells) Therefore LQM75 therapy (MMP9 (AIF AKR1C (AKR1C3 AKR1B1 (AKR1B10 MAPK1 (MAPK14 EN3 4dichlorophenylmethyl34phenoxyphenyl2propenamide EN dichlorophenylmethyl 34 3, (LQM75 LQM7 (MMP (AKR1C AKR1B (AKR1B1 (MAPK1 dichlorophenylmethylphenoxyphenylpropenamide (LQM7 (AKR1B (MAPK (LQM

Resumen El objetivo de este estudio es explorar las diferencias en el malestar psicológico de adultos jóvenes en función de factores socioeconómicos: sexo, miedo al delito, confianza generalizada, victimización y satisfacción con la democracia. Se realizó un estudio cuantitativo, transversal, exploratorio y descriptivo con 937 participantes de Ecuador, España y México, quienes respondieron el CORE-10 (Clinical Outcomes in Routine Evaluation-10) y un cuestionario sobre condiciones de vida. Se realizaron análisis no paramétricos de diferencias entre grupos. Se encontraron diferencias significativas en Ecuador con los factores victimización indirecta, confianza generalizada y miedo al delito; en España con victimización directa, confianza generalizada y miedo al delito; y en México con sexo, confianza generalizada, miedo al delito y satisfacción con la democracia. Los hallazgos respaldan la idea de que la adversidad psicosocial puede incidir en el bienestar psicológico. Estos resultados pueden tener implicaciones para el diseño de acciones de prevención e intervención que trasciendan una visión biomédica dirigidas a adultos jóvenes.

Abstract The objective of this study is to explore the differences in the psychological distress of young adults according to socioeconomic factors: sex, fear of crime, generalized trust, victimization, and satisfaction with democracy. A quantitative, cross-sectional, exploratory, and descriptive research was conducted with 937 participants from Ecuador, Spain, and Mexico, who answered the Clinical Outcomes in Routine Evaluation-10 (CORE-10) and a questionnaire on living conditions. Non-parametric analyses of differences between groups were performed. There were significant differences in Ecuador with indirect victimization, generalized confidence, and fear of crime; in Spain with direct victimization, generalized trust, and fear of crime; and in Mexico with gender, generalized trust, fear of crime, and satisfaction with democracy. Findings support the idea that psychosocial adversity can affect psychological wellbeing. These findings may have implications for the design of prevention and intervention actions that transcend a biomedical view directed towards young adults.

RESUMEN México no está exento de la creciente preocupación mundial por el incremento de la contaminación atmosférica y sus efectos nocivos para la salud, por lo que el objetivo del presente trabajo es determinar el índice de riesgo a la salud por inhalación de partículas suspendidas menores a 2.5 μm (PM2.5) presentes en la atmósfera de la República Mexicana. Para ello, se revisó la cantidad de redes de monitoreo atmosférico que existen en la república (36) y cuántas de ellas contaban con datos disponibles sobre PM2.5 (9), así como con datos meteorológicos (dirección y velocidad del viento, temperatura) durante el periodo 2016-2019. Se elaboraron cuadros de datos para cada una de las redes de los estados de la república y con ellas se determinó el comportamiento espacial de las PM2.5 y de las variables meteorológicas. Se calculó el índice de riesgo a la salud y se determinó que los sitios con mayor índice de riesgo por inhalación de PM2.5 fueron, en primer lugar, San Cristóbal en el Estado de México, y en segundo lugar Xalostoc en la Ciudad de México.

ABSTRACT Mexico is not exempt from the growing global concern about the increase in air pollution and its harmful effects on health. Therefore, this study aims to determine the health risk index for PM2.5 inhalation present in Mexico’s atmosphere. To this end, the number of atmospheric monitoring networks in the country (36) was reviewed, and how many of them had available data on PM2.5 (9), as well as meteorological data (wind direction and speed, temperature) during the period 2016-2019. Data tables were produced for each monitoring network, and the spatial behavior and meteorological variables of PM2.5 were determined. The health risk index was calculated, and it was determined that the sites with the highest risk index for PM2.5 inhalation in Mexico were, first, San Cristóbal in the State of Mexico and second, Xalostoc in Mexico City.