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RESUMO Contexto: Nas últimas décadas, a ecoendoscopia evoluiu de uma ferramenta diagnóstica para uma plataforma para diversas intervenções terapêuticas. Vários avanços tecnológicos surgiram desde o último Consenso Brasileiro, demandando uma revisão e atualização das recomendações baseadas nas melhores evidências científicas. Métodos: Um grupo de 32 ecoendoscopistas renomados selecionou oito tópicos relevantes para serem discutidos a fim de gerar questões clínicas. Em seguida, foi realizada uma revisão da literatura para responder a essas perguntas com base nas evidências mais atualizadas. Resultados: Trinta e três tópicos foram formulados e votados pelos especialistas para alcançar um consenso. O Sistema de Oxford foi utilizado para classificar o nível de evidência. Conclusão: Há evidências moderadas para sustentar que a forma da agulha, calibre ou técnica de aspiração não influenciam no rendimento da amostragem tecidual guiada por ultrassom endoscópico (USE) de lesões sólidas pancreáticas. Há evidências moderadas para sustentar o uso da biópsia transcutânea guiada por USE da parede cística para diferenciar entre neoplasias císticas mucinosas e não mucinosas. Existem poucas evidências para apoiar o tratamento guiado por USE de varizes gástricas. Há um alto nível de evidência para sustentar que a drenagem biliar guiada por USE e a CPRE apresentam resultados semelhantes em pacientes com obstrução biliar maligna distal. Há um alto nível de evidência para o uso da USE no diagnóstico de cistos pancreáticos neoplásicos e na detecção de necrose antes de indicar a drenagem. Há evidências moderadas para sustentar a preferência pela gastroenterostomia guiada por USE em relação ao stent duodenal para obstrução maligna da saída gástrica em pacientes com expectativa de vida superior a 2 meses. Há um alto nível de evidência para sustentar o uso da ablação por radiofrequência no tratamento de ambos os tipos, funcionantes e não funcionantes, de tumores neuroendócrinos. Contexto décadas terapêuticas Brasileiro científicas Métodos 3 clínicas seguida atualizadas Resultados consenso Conclusão agulha (USE pancreáticas gástricas distal meses tipos neuroendócrinos

ABSTRACT Background: In the past decades, endoscopic ultrasound has developed from a diagnostic tool to a platform for many therapeutic interventions. Various technological advancements have emerged since the last Brazilian Consensus, demanding a review and update of the recommendations based on the best scientific evidence. Methods: A group of 32 renowned echoendoscopists selected eight relevant topics to be discussed to generate clinical questions. After that, a literature review was conducted to answer these questions based on the most updated evidence. Results: Thirty-three statements were formulated and voted on by the experts to reach a consensus. The Oxford System was used to grade the level of evidence. Conclusion: There is moderate evidence to support that the needle shape, gauge, or aspiration technique does not influence the yield of endoscopic ultrasound (EUS)-guided tissue sampling of pancreatic solid lesions. There is moderate evidence to support using EUS-TTNB of the cyst wall to differentiate between mucinous and non-mucinous cystic neoplasms. There is little evidence to support the EUS-guided treatment of gastric varices. There is a high level of evidence to support that EUS-guided biliary drainage and ERCP present similar outcomes in patients with distal malignant biliary obstruction. There is a high level of evidence for using EUS to diagnose neoplastic pancreatic cysts and detect necrosis before indicating drainage. There is moderate evidence to support EUS-GE over duodenal stent for malignant gastric outlet obstruction in patients with a life expectancy higher than 2 months. There is a high level of evidence to support the use of RFA in treating both functioning and non-functioning types of NET. Background decades interventions Consensus Methods 3 Results Thirtythree Thirty three consensus Conclusion shape gauge EUSguided guided lesions EUSTTNB TTNB nonmucinous non neoplasms varices EUSGE GE months nonfunctioning NET

https://doi.org/10.1590/s0004-2803.24612024-062

Acute renal failure, COVID-19 and deaths, worrying rates in intensive care units: a cross-sectional study failure COVID19 COVID 19 COVID-1 deaths units crosssectional cross sectional COVID1 1 COVID-
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Watanabe, Yoshimi José Ávila

; Carvalho, Lívia Maria Rezende

; Guedes, João Victor Marques

; Baldoni, André Oliveira

; Belo, Vinícius Silva

; Otoni, Alba

Sao Paulo Medical Journal

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2024, Volume 142 N. 6 elocation e2023150

Abstract: En | Text: En | PDF: En

ABSTRACT BACKGROUND: Acute kidney failure is a serious consequence of coronavirus disease 2019 (COVID-19). OBJECTIVES: To identify the prevalence of COVID-19, kidney failure, frequency of death, and associated factors in patients receiving intensive care. DESIGN AND SETTING: Analytical cross-sectional study conducted in the intensive care unit (ICU) of a medium-sized philanthropic general hospital in center-west Minas Gerais. METHODS: Adults and older individuals who underwent real-time polymerase chain reaction testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were evaluated by the nephrology team. RESULTS: Among the 176 patients, the prevalence of COVID-19 and acute kidney injury (AKI) were 103 (58.5%) and 132 (75%), respectively, and 44 (25%) had chronic kidney disease (CKD) and 16 (15,5%) were positive for SARS-CoV-2. In the Charlson index classification, which estimates the risk of death, a statistically significant difference was identified in the percentages of groups with and without COVID-19 for indices 0, 1, and 2. There was a significant association between kidney disease and ICU mortality (P < 0.05). Patients with CKD had fewer fatal outcomes (13/97, 13.4%) than those with AKI (85/97, 87.6%). CONCLUSIONS: COVID-19 rates remained high long after diagnosis and prevention of SARS-CoV-2 infection. In addition, a higher death rate among patients who developed AKI, whose prevalence was also greater than that in the national literature, regardless of the presence of COVID-19, revealed a worrying scenario and corroborated the need for early and judicious approaches to preserve the lives of patients with AKI admitted to intensive care units. BACKGROUND 201 COVID19. COVID19 COVID 19 . (COVID-19) OBJECTIVES COVID19, 19, SETTING crosssectional cross sectional (ICU mediumsized medium sized centerwest center west Gerais METHODS realtime real time SARSCoV2 SARSCoV SARS CoV (SARS-CoV-2 team RESULTS 17 COVID-1 (AKI 10 58.5% 585 58 5 (58.5% 13 75%, 75 75% , (75%) respectively 4 25% 25 (25% (CKD 1 15,5% 155 15 (15,5% SARSCoV2. classification 0 P 0.05. 005 0.05 05 0.05) 13/97, 1397 97 (13/97 13.4% 134 85/97, 8597 85 (85/97 87.6%. 876 87.6% 87 6 87.6%) CONCLUSIONS SARS-CoV- infection addition literature units 20 COVID1 (COVID-19 (SARS-CoV- COVID- 58.5 (58.5 7 (75% (25 15,5 (15,5 00 0.0 13/97 139 9 (13/9 13.4 85/97 859 8 (85/9 87.6 SARS-CoV (COVID-1 (SARS-CoV 58. (58. (75 (2 15, (15, 0. 13/9 (13/ 13. 85/9 (85/ 87. (COVID- (58 (7 ( (15 13/ (13 85/ (85 (COVID (5 (1 (8

https://doi.org/10.1590/1516-3180.2023.0150.r1.13052024

Mapeamento das práticas e abordagens de terapeutas ocupacionais na doença de Parkinson: uma revisão de escopo Parkinson
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Oliveira, Gabriela do Monte

; Basílio, Sarah Almeida Rodrigues

; Omura, Kátia Maki

; Kovic, Mark

; Larsen, Anette Enemark

; Cardoso, Marcelo Marques

; Corrêa, Victor Augusto Cavaleiro

Cadernos Brasileiros de Terapia Ocupacional

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2024, Volume 32 elocation e3349

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Introdução A doença de Parkinson (DP) é a segunda no grupo das doenças neurodegenerativas crônicas progressivas, com alta prevalência e incidência anual. Portanto, faz-se necessário atualizar as opções terapêutico-ocupacionais, vigentes ou em desenvolvimento, para essa patologia. Objetivo Mapear as práticas e abordagens de terapeutas ocupacionais conduzidas por meio de intervenções terapêuticas na DP. Método Revisão conduzida em atenção ao “Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) Checklist”, baseada na metodologia do Joanna Briggs Institute. A pergunta de pesquisa foi elaborada a partir do acrônimo PCC (Paciente, Conceito e Contexto), cujos termos principais e secundários foram consultados no DeCS/MeSH. As buscas foram realizadas em cinco plataformas científicas entre 2011 e 2020. Os pesquisadores cegos foram comparados pelo grau de concordância aferido pelo coeficiente kappa de Cohen. Resultados Os achados indicam que há pelo menos oito categorias de práticas e abordagens realizadas por terapeutas ocupacionais na DP. A maioria dos procedimentos é executado no domicílio. A pesquisa em ambiente ambulatorial é o grande cenário de produção de conhecimento na área. As estratégias focadas em condutas físicas e funcionais são as mais demandadas na DP, com resultados aferíveis, ao passo que as intervenções baseadas em ocupações manifestam resultados discretos. Conclusão As atuações do terapeuta ocupacional na DP têm ampla variabilidade, ocorrem em diferentes contextos e seus desfechos sugerem que nem todas as opções mapeadas apresentam resultados consistentes ou não são suficientemente detalhadas para favorecer uma melhor interpretação dos achados. (DP progressivas anual Portanto fazse faz se terapêuticoocupacionais, terapêuticoocupacionais terapêutico ocupacionais, terapêutico-ocupacionais desenvolvimento patologia Preferred MetaAnalyses Meta Analyses PRISMAScR PRISMA ScR (PRISMA-ScR Checklist, Checklist , Checklist” Institute Paciente, Paciente (Paciente Contexto, Contexto Contexto) DeCSMeSH DeCS MeSH DeCS/MeSH 201 2020 Cohen domicílio área aferíveis discretos variabilidade 20 202 2

Abstract Introduction Parkinson’s disease (PD) ranks second among progressive chronic neurodegenerative diseases, with high prevalence and annual incidence. Therefore, it is necessary to update the current and developing occupational therapy options for this pathology. Objective To map the practices and approaches of occupational therapists conducted through therapeutic interventions in PD. Method Review conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) Checklist, based on the methodology of the Joanna Briggs Institute. The research question was formulated using the PCC (Patient, Concept, and Context) acronym, with primary and secondary terms consulted in the DeCS/MeSH multilingual thesaurus. Searches were conducted on five scientific databases between 2011 and 2020. Blind researchers were compared by the degree of agreement measured by Cohen’s kappa coefficient. Results The findings indicate that there are at least eight categories of practices and approaches performed by occupational therapists in PD. Most procedures are conducted at home. Research in outpatient environments is the primary setting for knowledge production in the field. Strategies focused on physical and functional behaviors are most in demand in PD, with measurable results, while occupation-based interventions show modest results. Conclusion The actions of occupational therapists in PD are highly variable, occur in different contexts, and their outcomes suggest that not all mapped options present consistent results or are not sufficiently detailed to favor a better interpretation of the findings. Parkinsons Parkinson s (PD diseases incidence Therefore pathology MetaAnalyses Meta Analyses PRISMAScR PRISMA ScR (PRISMA-ScR Checklist Institute Patient, Patient (Patient Concept Context acronym DeCSMeSH DeCS MeSH thesaurus 201 2020 Cohens Cohen coefficient home field occupationbased occupation variable contexts 20 202 2

https://doi.org/10.1590/2526-8910.ctoar256833491

POSTERIOR CRUCIATE LIGAMENT RECONSTRUCTION: ARE THE RESULTS SIMILAR TO ANTERIOR CRUCIATE LIGAMENT RECONSTRUCTION? RECONSTRUCTION
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MESTRINER, MARCOS BARBIERI

; HIROSSE, FÁBIO EIDI

; RABELO, NAYRA DEISE DOS ANJOS

; SANTOS NETTO, ALFREDO DOS

; OLIVEIRA, VICTOR MARQUES DE

; CURY, RICARDO DE PAULA LEITE

Acta Ortopédica Brasileira

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2023, Volume 31 N. 2 elocation e260740

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Objetivo: Reportar e comparar os resultados da reconstrução do ligamento cruzado posterior (LCP) e do ligamento cruzado anterior (LCA). Métodos: Foram avaliados retrospectivamente 42 pacientes: 20 com lesão isolada do LCP (grupo 1) e 22 com lesão isolada do LCA (grupo 2), submetidos à reconstrução ligamentar artroscópica com enxertos autólogos e acompanhados por pelo menos dois anos. Para avaliação dos resultados no grupo 1, foram utilizados o escore do International Knee Documentation Committee (IKDC) objetivo, escore de Lysholm, teste da gaveta posterior e avaliação pelo artrômetro KT-1000; e, para o grupo 2, foram utilizados o IKDC subjetivo, escore Lysholm e teste de Lachman. Para comparação entre os grupos, foram considerados o IKDC objetivo, escore Lysholm e avaliação pelo artrômetro KT-1000. Resultados: Ambos os grupos demonstraram melhora dos resultados na análise intragrupo em todas as variáveis (p < 0,001). Na comparação intergrupos, observou-se diferença significativa no IKDC objetivo (p < 0,001), não sendo observada diferença no escore Lysholm (p = 0,052), nos testes clínicos (p = 0,058) ou na avaliação pelo KT-1000 (p = 0,129). Conclusão: A estabilidade e função do joelho foram restauradas em ambos os grupos. Na comparação intergrupos, a reconstrução do LCP apresentou resultados inferiores à reconstrução do LCA no critério IKDC objetivo. Nível de Evidência II, Estudo Retrospectivo. Objetivo (LCP LCA. . (LCA) Métodos 4 pacientes 2 1 , 2) anos (IKDC KT1000 KT 1000 subjetivo Lachman KT1000. 1000. Resultados p 0,001. 0001 0,001 0 001 0,001) intergrupos observouse observou se 0,001, 0,052, 0052 0,052 052 0,052) 0,058 0058 058 KT-100 0,129. 0129 0,129 129 0,129) Conclusão II Retrospectivo (LCA KT100 100 000 0,00 00 005 0,05 05 KT-10 012 0,12 12 KT10 10 0,0 KT-1 01 0,1 KT1 0, KT-

ABSTRACT Objective: To report and compare the results of posterior cruciate ligament (PCL) and anterior cruciate ligament (ACL) reconstructions. Methods: In total, 42 patients were retrospectively evaluated, 20 with isolated PCL injuries (group 1) and 22 with isolated ACL ones (group 2) who were subjected to arthroscopic ligament reconstruction with autologous grafts and followed up for at least two years. To evaluate the results in group 1, objective IKDC and Lysholm scores, posterior drawer tests, and evaluations by a KT-1000 arthrometer were used, whereas for group 2, subjective IKDC and Lysholm score and the Lachman test were employed. To compare groups, objective IKDC and Lysholm scores and assessment via a KT-1000 arthrometer were considered. Results: Intragroup analysis showed improved results for all variables (p < 0.001) in both groups. Comparisons between groups showed a significant difference in objective IKDC scores (p < 0.001), but no such disparities for Lysholm ones (p = 0.052), clinical tests (p = 0.058) or evaluation by KT-1000 (p = 0.129). Conclusion: Treatment restored knee stability and function in both groups. Comparisons between groups showed that PCL reconstructions had inferior results than ACL ones according to patients’ objective IKDC scores. Level of Evidence II, Retrospective Study. Objective (PCL (ACL Methods total 4 evaluated 2 1 years KT1000 KT 1000 KT-100 used employed considered Results p 0.001 0001 0 001 0.001, , 0.052, 0052 0.052 052 0.052) 0.058 0058 058 0.129. 0129 0.129 . 129 0.129) Conclusion II Study KT100 100 KT-10 0.00 000 00 005 0.05 05 012 0.12 12 KT10 10 KT-1 0.0 01 0.1 KT1 KT- 0.

https://doi.org/10.1590/1413-785220233102e260740

COVID-19 outcomes in people living with HIV: Peering through the waves COVID19 COVID 19 COVID-1 HIV COVID1 1 COVID-
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Sales, Thaís Lorenna Souza

; Souza-Silva, Maíra Viana Rego

; Delfino-Pereira, Polianna

; Neves, João Victor Baroni

; Sacioto, Manuela Furtado

; Assis, Vivian Costa Morais de

; Duani, Helena

; Oliveira, Neimy Ramos de

; Sampaio, Natália da Cunha Severino

; Ramos, Lucas Emanuel Ferreira

; Schwarzbold, Alexandre Vargas

; Jorge, Alzira de Oliveira

; Scotton, Ana Luiza Bahia Alves

; Castro, Bruno Mateus de

; Silva, Carla Thais Cândida Alves da

; Ramos, Carolina Marques

; Anschau, Fernando

; Botoni, Fernando Antonio

; Grizende, Genna Maira Santos

; Nascimento, Guilherme Fagundes

; Ruschel, Karen Brasil

; Menezes, Luanna Silva Monteiro

; Castro, Luís César de

; Nasi, Luiz Antônio

; Carneiro, Marcelo

; Godoy, Mariana Frizzo de

; Nogueira, Matheus Carvalho Alves

; Guimarães Júnior, Milton Henriques

; Ziegelmann, Patricia Klarmann

; Almeida, Rafaela Charão de

; Francisco, Saionara Cristina

; Silveira Neto, Sidney Teodoro

; Araújo, Silvia Ferreira

; Avelino-Silva, Thiago Junqueira

; Aliberti, Márlon Juliano Romero

; Pires, Magda Carvalho

; Silva, Eduardo Sérgio da

; Marcolino, Milena Soriano

Clinics

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2023, Volume 78 elocation 100223

Abstract: En | Text: En | PDF: En

Abstract Objective To evaluate clinical characteristics and outcomes of COVID-19 patients infected with HIV, and to compare with a paired sample without HIV infection. Methods This is a substudy of a Brazilian multicentric cohort that comprised two periods (2020 and 2021). Data was obtained through the retrospective review of medical records. Primary outcomes were admission to the intensive care unit, invasive mechanical ventilation, and death. Patients with HIV and controls were matched for age, sex, number of comorbidities, and hospital of origin using the technique of propensity score matching (up to 4:1). They were compared using the Chi-Square or Fisher's Exact tests for categorical variables and the Wilcoxon for numerical variables. Results Throughout the study, 17,101 COVID-19 patients were hospitalized, and 130 (0.76%) of those were infected with HIV. The median age was 54 (IQR: 43.0;64.0) years in 2020 and 53 (IQR: 46.0;63.5) years in 2021, with a predominance of females in both periods. People Living with HIV (PLHIV) and their controls showed similar prevalence for admission to the ICU and invasive mechanical ventilation requirement in the two periods, with no significant differences. In 2020, in-hospital mortality was higher in the PLHIV compared to the controls (27.9% vs. 17.7%; p = 0.049), but there was no difference in mortality between groups in 2021 (25.0% vs. 25.1%; p > 0.999). Conclusions Our results reiterate that PLHIV were at higher risk of COVID-19 mortality in the early stages of the pandemic, however, this finding did not sustain in 2021, when the mortality rate is similar to the control group. COVID19 COVID 19 COVID-1 infection (202 2021. . 2021) records unit death sex comorbidities up 41. 41 4 1 4:1) ChiSquare Chi Square Fishers Fisher s study 17101 17 101 17,10 hospitalized 13 0.76% 076 0 76 (0.76% 5 IQR (IQR 43.064.0 430640 43.0 64.0 43 64 43.0;64.0 202 46.063.5 460635 46.0 63.5 46 63 46.0;63.5 (PLHIV differences inhospital 27.9% 279 27 9 (27.9 vs 17.7% 177 7 0.049, 0049 0.049 , 049 0.049) 25.0% 250 25 (25.0 25.1% 251 0.999. 0999 0.999 999 0.999) pandemic however group COVID1 COVID- (20 4:1 1710 10 17,1 0.76 07 (0.76 064 43.064. 43064 430 43. 640 64. 6 43.0;64. 20 063 46.063. 46063 460 46. 635 63. 46.0;63. 27.9 2 (27. 17.7 004 0.04 04 25.0 (25. 25.1 099 0.99 99 (2 4: 171 17, 0.7 (0.7 06 43.064 4306 43.0;64 46.063 4606 46.0;63 27. (27 17. 00 0.0 25. (25 09 0.9 ( 0. (0. 43.06 43.0;6 46.06 46.0;6 (0 43.0; 46.0;

https://doi.org/10.1016/j.clinsp.2023.100223

S. AUREUS IS ASSOCIATED WITH A GREATER NEED FOR REOPERATION IN SEPTIC ARTHRITIS OF THE KNEE S
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FERNANDES, LUCAS SAADE

; YAGI, ALEXANDRE JOJI

; SANTOS NETTO, ALFREDO DOS

; SALLES, MAURO JOSÉ

; OLIVEIRA, VICTOR MARQUES DE

; CURY, RICARDO DE PAULA LEITE

Acta Ortopédica Brasileira

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2023, Volume 31 N. 2 elocation e260592

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Objetivo: Determinar a frequência de reabordagens cirúrgicas no tratamento de pacientes adultos com diagnóstico de artrite séptica do joelho, a média de desbridamentos necessários para o controle da infecção e a taxa de mortalidade, assim como avaliar os fatores associados à maior necessidade de reabordagem e mortalidade. Métodos: Estudo retrospectivo tipo coorte que avaliou 38 pacientes adultos com diagnóstico de artrite séptica submetidos à artrotomia por via parapatelar medial para limpeza e desbridamento da articulação. Foram analisadas variáveis demográficas, clínicas, cirúrgicas e microbiológicas dos casos, por revisão de prontuário médico, e realizados testes de igualdade de duas proporções, qui-quadrado e análise multivariada de regressão logística, sendo definido um nível de significância de 0,05, com 95% de confiança estatística. Resultados: 50% dos casos foram submetidos à reabordagem cirúrgica, sendo a média de desbridamentos necessários de 2,02 e a taxa de mortalidade de 10,5%. Pacientes com infecção causada por Staphylococcus aureus apresentaram mais chances de necessitar de reabordagem quando comparados aos pacientes com culturas positivas para outros agentes (OR 6,0). Conclusão: Em 50% dos casos foram necessários, em média, 2,02 desbridamentos e a taxa de mortalidade foi de 10,5%. A infecção por Staphylococcus aureus está associada com seis vezes mais chances de cirurgias adicionais. Nível de Evidência IV, Série de Casos. Objetivo joelho Métodos 3 articulação demográficas clínicas médico proporções quiquadrado qui quadrado logística 005 0 05 0,05 95 estatística Resultados 50 cirúrgica 202 2 02 2,0 105 10 5 10,5% OR 6,0. 60 6,0 . 6 6,0) Conclusão adicionais IV Casos 00 0,0 9 20 2, 1 10,5 6, 0, 10,

ABSTRACT Objective: To determine the frequency of reoperations in the treatment of adult patients diagnosed with septic arthritis of the knee, the average number of debridements needed to control the infection, the mortality rate, and to assess factors associated with a greater need for reoperation and mortality. Methods: Retrospective cohort study evaluating 38 adult patients diagnosed with septic arthritis who underwent arthrotomy via a medial parapatellar approach for joint cleaning and debridement. Demographic, clinical, surgical, and microbiological variables of the cases were analyzed by review of medical records. Tests for equality of two proportions, chi-square, and multivariate logistic regression analysis were performed, defining a significance level at 0.05, with 95% confidence interval. Results: A total of 50% of the cases underwent reoperation, with an average number of required debridement of 2.02 and a mortality rate of 10.5%. Patients with infection caused by Staphylococcus aureus were more likely to need a reoperation compared to patients with positive cultures for other agents (OR 6.0). Conclusion: In 50% of cases, an average of 2.02 debridements were necessary and the mortality rate was 10.5%. Staphylococcus aureus infection is associated with a 6 times greater chance of additional surgeries. /Level of Evidence IV, Case Series. Objective knee Methods 3 Demographic clinical surgical records proportions chisquare, chisquare chi square, square chi-square performed 005 0 05 0.05 95 interval Results 50 202 2 02 2.0 105 10 5 10.5% OR 6.0. 60 6.0 . 6.0) Conclusion surgeries Level IV Series 00 0.0 9 20 2. 1 10.5 6. 0. 10.

https://doi.org/10.1590/1413-785220233102e260592

Antibiotics prescribing habits of Brazilian general dental practitioners during periodontal treatments
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CERIBELLI, Ariane Oliveira

; ALVES, Brenda Stephanie Batista

; TAJIMA, Thais Marques do Nascimento

; MARTINS, Christine Men

; BATISTA, Victor Eduardo de Souza

; SANTINONI, Carolina dos Santos

Revista de Odontologia da UNESP

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2023, Volume 52 elocation e20230026

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Introdução O tratamento periodontal envolve procedimentos que visam reduzir a carga bacteriana, envolvendo ou não o uso de antibióticos locais ou sistêmicos. Objetivo O objetivo deste estudo foi avaliar o conhecimento dos cirurgiões-dentistas brasileiros sobre a prescrição de antibióticos durante o tratamento periodontal. Material e método Foi disponibilizado um questionário online solicitando aplicação sistêmica de prescrição de antibióticos locais ou sistêmicos (frequência e sequência com tratamento periodontal mecânico) e em relação a diferentes doenças periodontais. A utilização de serviços de diagnóstico microbiano e dados demográficos dos voluntários também foram elucidados. Os dados foram analisados estatisticamente (Teste Binomial, p<0,05). Resultado Trezentos e noventa e três voluntários responderam ao questionário. Vinte e três por cento do sexo masculino e 76,2% do sexo feminino. A idade média foi de 27,7 anos. A minoria (19,2%) dos voluntários relatou indicar antibióticos sistêmicos para tratamento de gengivite ou periodontite estágios I e II (antiga periodontite crônica leve e moderada). A maioria dos profissionais indica para tratar abscesso periodontal, gengivite ou periodontite ulcerativa necrosante, periodontite em imunodeficiências graves, periodontite agressiva antiga e periodontite estágios III e IV (periodontite crônica grave antiga). Raramente (2,5%) a prescrição foi sem a associação com terapia mecânica. Os exames microbiológicos como método auxiliar de diagnóstico raramente (3,1%) são solicitados por falta de informação ou custo. As respostas mais frequentes sobre o número de vezes que os profissionais relataram prescrever antibióticos sistêmicos como parte do tratamento periodontal por trimestre foram “pelo menos uma vez”, seguido de “2 vezes”. Conclusão Pode-se concluir que os cirurgiões-dentistas brasileiros possuem conhecimento sobre a correta prescrição de antibióticos na terapia periodontal. bacteriana cirurgiõesdentistas cirurgiões dentistas frequência mecânico periodontais elucidados Teste Binomial p<0,05. p005 p p<0,05 . 0 05 p<0,05) 762 76 2 76,2 feminino 277 27 7 27, anos 19,2% 192 19 (19,2% moderada. moderada moderada) necrosante graves antiga. antiga) 2,5% 25 5 (2,5% mecânica 3,1% 31 3 1 (3,1% custo pelo vez, vez , vez” “ vezes. vezes” Podese Pode se p00 p<0,0 76, 19,2 (19,2 2,5 (2,5 3,1 (3,1 p0 p<0, 19, (19, 2, (2, 3, (3, p<0 (19 (2 (3 p< (1 (

Abstract Introduction Periodontal treatment involves procedures aimed to reduce bacterial load, involving or not the use of local or systemic antibiotics. Objective The purpose of this study was to assess Brazilian dentists’ knowledge about antibiotics prescription during periodontal treatment. Material and method An online questionnaire was available asking for systemic application of local or systemic antibiotics prescription (frequency, and sequence with mechanical periodontal treatment) and in relation to different periodontal diseases. The use of microbial diagnostic services and volunteers’ demographic data were also elucidated. Data were statistically analyzed (Binomial Test, p<0.05). Result Three hundred and ninety-three volunteers answered the questionnaire. Twenty-three percent males and 76.2% females. Average age was 27.7 years. Minority (19.2%) of the volunteers reported to indicate systemic antibiotics to treat gingivitis or periodontitis stages I and II (old slight and moderate chronic periodontitis). Majority of the professionals indicate it to treat periodontal abscess, necrotizing ulcerative gingivitis or periodontitis, periodontitis in severe immunodeficiencies, old aggressive periodontitis, and periodontitis stages III and IV (old severe chronic periodontitis). Rarely (2.5%) the prescription was without the combination with mechanical therapy. Microbiological tests as an auxiliary diagnostic method are rarely (3.1%) requested due to lack of information or cost. Most frequent answers about the number of times professionals reported prescribing systemic antibiotics as part of periodontal treatment per trimester was “at least once”, followed by “2 times”. Conclusion It can be concluded that Brazilian dentists have knowledge about the correct prescription of antibiotics in periodontal therapy. load frequency, frequency (frequency diseases elucidated Binomial Test p<0.05. p005 p p<0.05 . 0 05 p<0.05) ninetythree ninety three Twentythree Twenty 762 76 2 76.2 females 277 27 7 27. years 19.2% 192 19 (19.2% periodontitis. periodontitis) abscess immunodeficiencies 2.5% 25 5 (2.5% therapy 3.1% 31 3 1 (3.1% cost at once, once , once” “ times. times” p00 p<0.0 76. 19.2 (19.2 2.5 (2.5 3.1 (3.1 p0 p<0. 19. (19. 2. (2. 3. (3. p<0 (19 (2 (3 p< (1 (

https://doi.org/10.1590/1807-2577.02623

Does the Number of Stimuli Influence the Formation of the Endogenous Components of the Event-Related Auditory Evoked Potentials? EventRelated Event Related Potentials
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Oliveira, Yorran Marques de

; Calderaro, Victor Goiris

; Massuda, Eduardo Tanaka

; Zanchetta, Sthella

; Simões, Humberto de Oliveira

International Archives of Otorhinolaryngology

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2023, Volume 27 N. 4 Pages 636 - 644

Abstract: En | Text: En | PDF: En

Abstract Introduction The number of stimuli is important to determine the quality of auditory evoked potential records. However, there is no consensus on that number in studies, especially in the sample studied. Objectives To investigate the influence of the number of rare stimuli on forming N2 and P3 components, with different types of acoustic stimuli. Methods Cross-sectional, descriptive, comparative study, approved by the ethics committee of the institution. The sample comprised 20 normal hearing adults of both sexes, aged 18 to 29 years old, with normal scores in the mental state examination and auditory processing skills. The event-related auditory evoked potentials were performed with nonverbal (1 kHz versus 2 kHz) and verbal stimuli (/BA/ versus /DA/). The number of rare stimuli varied randomly in the recordings, with 10, 20, 30, 40, and 50 presentations. Results P3 latency was significantly higher for nonverbal stimuli with 50 rare stimuli. N2 latency did not show any difference between the type and number of stimuli. The absolute P3 and N2-P3 amplitudes showed significant differences for both types of stimuli, with higher amplitude for 10 rare stimuli, in contrast with the other ones. The linear tendency test indicated significance only for the amplitude – as the number of rare stimuli increased, the amplitude tended to decrease. Conclusion The components were identifiable in the different numbers of rare stimuli and types of stimuli. The P3 and N2-P3 latency and amplitude increased with fewer verbal and nonverbal stimuli. Recording protocols must consider the number of rare stimuli. records However studies studied N P Crosssectional, Crosssectional Cross sectional, sectional Cross-sectional descriptive study institution sexes 1 old skills eventrelated event related ( /BA/ BA (/BA /DA/. DA /DA/ . /DA/) recordings 30 40 5 presentations N2P3 NP N2-P ones decrease /BA /DA 3 4 N2P

https://doi.org/10.1055/s-0042-1759605

Soil carbon stocks and labile fractions of organic matter under agroforestry system in breast of pernambucan altitude
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Crespo, Cristiane Maria Gonçalves

; Piscoya, Victor Casimiro

; Araujo Filho, Renisson Neponuceno de

; Lima, Samila Bezerra

; Moraes, Alex Souza

; França, Manoel Vieira de

; Fernandes, Milton Marques

; Cunha Filho, Moacyr

; Gomes Filho, Raimundo Rodrigues

; Cavalcante, Nayane Laisa de Lima

; Melo, Robson Carlos Pereira de

; Piscoya, Thaisa Folha

; Roncal, Jorge Piscoya

; Pereira, Ludmilla Morais

; Holanda, Francisco Sandro Rodrigues

; Pedrotti, Alceu

; Feitosa, Thaiana Brunes

; Oliveira, Patrick Peres

Ciência Florestal

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dec 2022, Volume 32 N. 4 Pages 2180 - 2198

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo O intenso preparo e revolvimento do solo em cultivos, com o tempo, reduz a quantidade e a qualidade da matéria orgânica do solo. Diante desse contexto, este trabalho teve como objetivo determinar os estoques de carbono do solo e frações lábeis sob sistema agroflorestal (SAF) e topossequências em brejo de altitude, em Taquaritinga do Norte, Pernambuco, Brasil. O estudo foi desenvolvido na fazenda Yaguara, e as áreas estudadas foram mata nativa com 4,57 ha e plantio de café sombreado com mata nativa com 25,59 ha. As amostras de solos foram coletadas em quatro trincheiras 1,5 x 1,5 x 0,60 m, com distância de 50 metros. Foram coletados solos nas profundidades de 0-20, 20-40 e 40-60 cm, seguido de análises químicas, físicas e densidade para determinação dos estoques de carbono no solo e frações lábeis. A área com café sombreado apresentou maiores valores de estoques de carbono no solo nas profundidades de 0-20 cm e 20-40 cm. Na profundidade de 40-60 cm, a topossequência de topo do SAF apresentou maior estoque de carbono com 11,73 Mg ha-1, seguido da área com vegetação nativa com 10,6 Mg ha-1 , encosta com 9,23 Mg ha-1 e pedimento com 7,00 Mg ha-1. Verificou-se que a topossequência de topo com café sombreado exibiu maior estoque de carbono lábil na profundidade 0-20 cm com o valor de 1,06 Mg ha-1, sucedido das áreas de pedimento (SAF) com 0,88 Mg ha-1, mata nativa com 0,79 Mg ha-1e encosta com 0,67 Mg ha-1. No entanto, a área de vegetação nativa apresentou o maior valor de carbono lábil na profundidade de 40-60 cm. Concluiu-se que a área com café sombreado na topossequência topo mostrou grande capacidade para elevar os estoques de carbono total e estoques de carbono lábil da matéria orgânica do solo. cultivos tempo contexto (SAF altitude Norte Pernambuco Brasil Yaguara 457 4 57 4,5 2559 25 59 25,5 15 1 5 1, 060 0 60 0,6 m metros 020, 020 20, 20 2040 40 20-4 4060 40-6 químicas 0-2 1173 11 73 11,7 ha1, ha1 106 10 6 10, ha- 923 9 23 9,2 700 7 00 7,0 ha1. 1. Verificouse Verificou se 06 1,0 088 88 0,8 079 79 0,7 ha1e hae 1e 067 67 entanto Concluiuse Concluiu 45 4, 255 2 25, 0, 02 204 20- 406 40- 0- 117 11, 92 9, 70 7, 08 8 07

Abstract Intense soil preparation and disturbance in crops, over time, reduces the quantity and quality of soil organic matter. Given this context, this work aimed to determine soil carbon stocks and labile fractions under agroforestry system (AFS) and toposequences in an altitude marsh, Taquaritinga do Norte, Pernambuco, Brazil. The study was carried out at the Yaguara farm, and the areas studied were native forest with 4.57 ha and coffee plantation in shade with native forest with 25.59 ha. Soil samples were collected in four trenches measuring 1.5 x 1.5 x 0.60 m, with a distance of 50 meters. Soils were collected at depths of 0-20, 20-40 and 40-60 cm, followed by chemical, physical and density analyzes to determine soil carbon stocks and labile fractions. The area with shaded coffee showed higher values of soil carbon stocks at depths of 0-20 cm and 20-40 cm. At a depth of 40-60 cm, the AFS top toposequence showed the highest carbon stock with 11.73 Mg ha-1, followed by the area with native vegetation with 10.6 Mg ha-1, slope with 9.23 Mg ha-1 and pediment with 7.00 Mg ha-1. It was found that the top toposequence with shaded coffee exhibited a greater stock of labile carbon at depth 0-20 cm with a value of 1.06 Mg ha-1, followed by the bedding areas (SAF) with 0.88 Mg ha-1, native forest with 0.79 Mg ha-1 and slope with 0.67 g kg-1. However, the area of native vegetation showed the highest value of labile carbon at a depth of 40-60 cm. It was concluded that the area with shaded coffee in the top toposequence showed great capacity to increase total carbon stocks and labile carbon stocks of soil organic matter. crops time matter context (AFS marsh Norte Pernambuco Brazil farm 457 4 57 4.5 2559 25 59 25.5 15 1 5 1. 060 0 60 0.6 m meters 020, 020 20, 20 2040 40 20-4 4060 40-6 chemical 0-2 1173 11 73 11.7 ha1, ha1 1, 106 10 6 10. 923 9 23 9.2 ha- 700 7 00 7.0 ha1. 06 1.0 SAF (SAF 088 88 0.8 079 79 0.7 067 67 kg1. kg1 kg kg-1 However 45 4. 255 2 25. 0. 02 204 20- 406 40- 0- 117 11. 92 9. 70 7. 08 8 07 kg-

https://doi.org/10.5902/1980509867374

10.

O uso do QR Code para uma gestão inclusiva na arborização urbana de Bagé, RS
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Grala, Ketileen

; Rosseto, Vanessa

; Rodrigues, Rennata Oliveira

; Martins, Marcio Marques

; Sampaio, Norton Victor

; Sampaio, Tanira Maria Gimenez

Interações (Campo Grande)

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sep 2022, Volume 23 N. 3 Pages 759 - 775

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

Resumo: O Programa Arborização Urbana: Um Exercício de Cidadania e Sustentabilidade Socioambiental, da Universidade Federal do Pampa (UNIPAMPA), na cidade de Bagé, RS, desenvolveu um projeto voltado para o uso de Tecnologias de Informação e Comunicação (TIC) e acessibilidade, que agregou o contexto de inclusão social ao trabalho de identificação de árvores de praças da cidade. A base para este trabalho foi o Inventário Arbóreo das Principais Ruas e Praças da Cidade de Bagé, RS, realizado no período de 2014 a 2016, de forma voluntária por insttuições de ensino e voluntários da comunidade. Dada a relevância do tema da inclusão social, foram desenvolvidas ferramentas voltadas ao atendimento das necessidades especiais, objetivando a interação de grupos com deficiência auditiva e visual com as informações levantadas no inventário arbóreo, sobre as espécies ocorrentes na Praça do Coreto, localizada na região central da cidade. Foram utilizando placas contendo QR Codes que direcionam o leitor a vídeos na Língua Brasileira de Sinais (LIBRAS), para o acesso de deficientes auditivos, e placa central, com recursos em Braile, para o acesso de deficientes visuais, visando popularizar os dados científicos do inventário arbóreo e ampliar o alcance do trabalho de Educação Ambiental para outros grupos da sociedade sem oportunidade de acessar informações sobre a arborização urbana.

Abstract: The Urban Forestry Program: An Exercise of Citizenship and Socio-Environmental Sustainability, from the Federal University of Pampa (UNIPAMPA), in the city of Bagé, RS, developed a project aimed at the use of Information and Communication Technologies (ICT) and accessibility, which added the context of social inclusion to the work of identifying trees in the city’s squares. The basis for this work was the Arboreal Inventory of the Main Streets and Squares of the City of Bagé, RS, carried out from 2014 to 2016, voluntarily, by educational institutions and community volunteers. Given the relevance of the social inclusion theme, tools were developed focusing to meeting special needs, aimed at the interaction of groups with hearing and visual impairments with the information collected in the arboreal inventory, about the species occurring in the Praça do Coreto, located in the central region of the city. Plates containing QR Codes were used to direct the reader to videos in Brazilian Sign Language (LIBRAS) – for the access of the hearing impaired – and a central plate with resources in Braille – for the access of the visually impaired –, aiming to popularize the scientific data of the arboreal inventory and expand the reach of the Environmental Education work for other groups in society with no opportunity to access information about urban forestry.

Resumen: El Programa Forestación Urbana: Un Ejercicio de Ciudadanía y Sostenibilidad Socioambiental, de la Universidad Federal de Pampa (UNIPAMPA), en la ciudad de Bagé, RS, desarrolló un proyecto orientado al uso de las Tecnologías de la Información y la Comunicación (TIC) y accesibilidad, que sumó el contexto de inclusión social al trabajo de identificación de árboles en las plazas de la ciudad. La base de este trabajo fue el Inventario Arbóreo de las Principales Calles y Plazas de la Ciudad de Bagé, RS, realizado de 2014 a 2016, de forma voluntaria, por insttuciones educativas y voluntarios comunitarios. Dada la relevancia del tema de la inclusión social, se desarrollaron herramientas orientadas a atender necesidades especiales, apuntando a la interacción de grupos con discapacidad auditiva y visual con la información recolectada en el inventario arbóreo, sobre las especies que se encuentran en la Praça do Coreto, ubicada en la región central de la ciudad. Se utilizaron placas conteniendo Códigos QR que dirigen el lector a videos en la Lengua Brasileña de Señas (LIBRAS), para el acceso de personas con discapacidad auditiva, y una placa central con recursos en Braille, para el acceso de personas con discapacidad visual, con el objetivo de popularizar los datos científicos del inventario arbóreo y ampliar el alcance del trabajo de Educación Ambiental para otros grupos de la sociedad sin oportunidad de acceder a información sobre forestación urbana.

https://doi.org/10.20435/inter.v23i3.3527

11.

Misdiagnoses in a Brazilian population with amyotrophic lateral sclerosis
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Borghetti, Vinicius Stefani

; Cintra, Vívian Pedigone

; Ramos, Jean de Oliveira

; Marques, Vanessa Daccach

; Onofre, Patrícia Toscano

; Santana, Victor Augusto Souza

; Bezerra, Lua Flora Pereira

; Tomaselli, Pedro José

; Santos, André Cleriston José dos

; Sobreira, Claudia Ferreira da Rosa

; Marques Jr., Wilson

Arquivos de Neuro-Psiquiatria

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jul 2022, Volume 80 N. 7 Pages 676 - 680

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Antecedentes A esclerose lateral amiotrófica (ELA) é uma doença neurodegenerativa que afeta os neurônios motores superior e inferior. O diagnóstico correto no início da doença é, às vezes, muito difícil, pois os sintomas de início são muito semelhantes aos de outras síndromes neurológicas. Objetivo Este estudo teve como objetivo analisar as manifestações iniciais, a especialidade do primeiro médico visitado devido à queixa inicial, os diagnósticos errôneos, bem como as intervenções cirúrgicas desnecessárias em uma nova população brasileira acometida por ELA. Métodos Os prontuários médicos de 173 pacientes com ELA típica foram revisados. Resultados O presente estudo demonstrou que outros sintomas, além da fraqueza, foram muito frequentes como apresentação inicial da ELA, sendo a ortopedia a especialidade médica mais procurada pelos pacientes no início dos sintomas. Nossa frequência de diagnósticos errôneos foi de 69,7%, e em 7,1% deles foi realizada intervenção cirúrgica desnecessária. Conclusões A ELA apresenta um conjunto amplo de sinais e sintomas; portanto, há necessidade urgente de uma melhor educação de outras especialidades devido à alta frequência de diagnósticos equivocados observada na prática clínica. (ELA inferior vezes difícil neurológicas iniciais 17 revisados fraqueza 697 69 7 69,7% 71 1 7,1 desnecessária portanto clínica 6 69,7 7, 69,

Abstract Background Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that affects the upper and lower motor neurons. The correct diagnosis at the onset of the disease is sometimes very difficult, due to the symptoms being very similar to those of other neurological syndromes. Objective This study aimed to analyze the initial manifestations, the specialty of the first physician visited due the initial complaint, the misdiagnoses, as well as the unnecessary surgical interventions in a new ALS Brazilian population. Methods The medical records of 173 patients with typical ALS were reviewed. Results The present study demonstrated that other symptoms, besides weakness, were very frequent as initial presentation of ALS, and orthopedics was the medical specialty most sought by patients at the onset of symptoms. Our frequency of misdiagnoses was 69.7%, and in 7.1% of them, an unnecessary surgical intervention was performed. Conclusions Amyotrophic lateral sclerosis presents a very large pool of signs and symptoms; therefore, there is an urgent need of increasing the disease awareness to other specialties due to the high frequency of misdiagnoses observed in clinical practice. (ALS neurons difficult syndromes manifestations complaint population 17 reviewed weakness 697 69 7 69.7% 71 1 7.1 them performed therefore practice 6 69.7 7. 69.

https://doi.org/10.1055/s-0042-1755224

12.

SYNTHESIS OF GLYCEROL-FLUORINATED TRIAZOLE DERIVATIVES AND EVALUATION OF THEIR FUNGICIDAL ACTIVITY
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Barcelos, Fernando Fontes

; Silva, Lucas Fagundes da

; Gazolla, Poliana Aparecida Rodrigues

; Teixeira, Róbson Ricardo

; Queiroz, Vagner Tebaldi de

; Morais, Pedro Alves Bezerra

; Fonseca, Victor da Rocha

; Romão, Wanderson

; Lacerda Júnior, Valdemar

; Scherer, Rodrigo

; Oliveira, Fabrício Marques de

; Praça-Fontes, Milene Miranda

; Costa, Adilson Vidal

Química Nova

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jul 2022, Volume 45 N. 7 Pages 788 - 796

Abstract: En | Text: En | PDF: En

The control of fungal species in agriculture is mainly conducted with the use of contact or systemic fungicides. However, environmental and human health concerns and increased resistance of fungal species to existing fungicides have increased the pressure on researchers to find new active ingredients for fungal control which present low toxicity to non-target organisms, are environmentally safe, and can be applied at very low concentrations. It is herein described the synthesis of eleven glycerol triazole containing compounds (ten of them fluorinated derivatives) and evaluation of their fungicidal activity. Eight out of eleven synthesized compounds are novel and all of the glycerol derivatives were characterized using infrared (IR), nuclear magnetic ressonance (NMR), and mass spectrometry (MS) techniques. Theoretical calculations were also carried out and the results are discussed. Starting from glycerol, the triazole derivatives were prepared in four steps. Evaluation of them against Colletrotricum gloesporioides showed that compound 1-((2,2-dimethyl-1,3 dioxolan-4-yl)methyl)-4-(2-fluorophenyl)-1H-1,2,3-triazole (4d) (ED50 = 59.14 µg mL-1) was slightly more active than commercial fungicide tebuconazole (61.35 µg mL-1). Compound 4d presented attractive physicochemical features for agrochemical purposes as revealed by the calculated physicochemical parameters. It is believed that glycerol-fluorinated triazole derivatives can be explored towards the development of new chemicals for the control of fungal species.

https://doi.org/10.21577/0100-4042.20170880

13.

Subclinical Systolic Dysfunction during Chemotherapy for Breast Cancer
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Barroso, Geanne Maria Holanda de Menezes

; Teles, Júlio César Oliveira Costa

; Silva, Paulo Victor de Jesus

; Fonseca, Karin Yasmin Santos

; Aragão, Vinícius Antônio Santos

; Aquino, Marília Marques

; Melo, Enaldo Vieira de

; Ferreira, Karina Oliveira

; Assis, Ronnei José Feitosa de

; Alves, Michel Fabiano Silva

; Sousa, Antônio Carlos Sobral

; Oliveira, Joselina Luzia Menezes

International Journal of Cardiovascular Sciences

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mar 2022, Volume 35 N. 2 Pages 220 - 229

Abstract: En | Text: En | PDF: En

Abstract Background Cardiotoxicity is the main complication related to cancer therapy. Studies indicate that global longitudinal strain is an early detector of subclinical dysfunction of the left ventricle, preceding the decline in ejection fraction (EF). However, the reproducibility of such methodology has not been tested outside specialized centers. Objectives To assess the frequency of subclinical cardiotoxicity and to compare global longitudinal strain and EF measurements during the clinical course of patients undergoing chemotherapy for breast cancer. Methods This was an observational prospective study of 78 adult women who underwent serial echocardiograms (baseline and 1, 3, and 6 months after the beginning of chemotherapy), to evaluate biplane and 3D EF and global longitudinal strain. Cardiotoxicity and subclinical dysfunction were defined according to American Society of Echocardiography/European Association of Cardiovascular Imaging criteria. Statistical significance was set at p < 0.05. Results The mean age of the patients was 50.1 ± 11.48 years. The frequency of subclinical cardiotoxicity (defined by global longitudinal strain) was 14.9% after 30 days of chemotherapy, 16.7% after 3 months, and 19.7% after 6 months, compared to 4.5%, 3%, and 6.6%, respectively, when clinical cardiotoxicity was determined according to EF. The group that developed subclinical cardiotoxicity by 30 days (group A) had a higher frequency of clinical cardiotoxicity at 3 months (p=0.028) and a lower mean biplane EF after 30 days (p= 0.036) than the group that showed no evidence of subclinical cardiotoxicity (group B). Conclusion Subclinical cardiotoxicity was frequent and began early, being associated with a drop in EF during the clinical course.

https://doi.org/10.36660/ijcs.20210089

14.

Progression of chronic kidney disease in non- dialysis patients: a retrospective cohort
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Aquino, Jéssica Azevedo

; Oliveira, Cláudia Lorenzo

; Otoni, Alba

; Sanches, Cristina

; Guedes, João Victor Marques

; Morais, Diego Bruno

; Mendonça, Thays Santos

; Morais, Flávio Augusto

; Baldoni, André Oliveira

Brazilian Journal of Pharmaceutical Sciences

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2022, Volume 58 elocation e20249

Abstract: En | Text: En | PDF: En

Abstract Evidence on factors associated with the progression of chronic kidney disease (CKD) is still under construction. The present study aimed to evaluate sociodemographic, clinical, and drug use factors associated with the progression of CKD. A retrospective cohort study was conducted with 193 patients with CKD stages 3A to 5- non-dialysis followed for three years in a Brazilian city. The outcome was the evolution to renal replacement therapy (RRT) or death. A total of 52.3 % (n = 101) were men and 83.4 % (n = 161) elderly. The median age was 72.0 years, and 22.3 % (n = 44) progressed to RRT or death, and the three-year mortality rate was 20.2 %. Participants exposed to angiotensin converting enzyme inhibitors or angiotensin II receptor blockers had a lower risk of progressing to the outcome (hazard ratio (HR) 0.25; p = 0.003) and higher survival (p = 0.022) when compared to those not exposed to these drugs. Age (HR 1.06;) and use of omeprazole (HR 6.25; CI; p <0.01) and hydrochlorothiazide (HR 2.80; p = 0.028) increased the risks of RRT or death. The results highlight the importance of rational management of pharmacotherapy for patients with CKD.

https://doi.org/10.1590/s2175-97902022e20249

15.

Chemical composition and fermentation characteristics of maize silage with citrus pulp
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SOUZA, Amelina de Oliveira

; TAVEIRA, José Henrique da Silva

; SANTOS, Alessandro José Marques

; FERNANDES, Patrick Bezerra

; COSTA, Kátia Aparecida de Pinho

; COSTA, Carolina Marques

; GURGEL, Antonio Leandro Chaves

; SILVA, Ana Carolina Gomes

; COSTA, João Victor Campos Pinho

Revista Brasileira de Saúde e Produção Animal

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2022, Volume 23 elocation e21352022

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO O objetivo deste trabalho foi avaliar o efeito da inclusão de polpa cítrica na silagem de milho sobre a composição química e parâmetros de fermentação. O delineamento experimental utilizado foi o inteiramente casualizado, com quatro repetições. Os tratamentos foram: Silagem de milho sem polpa cítrica (0%); silagem de milho com 10% 39 de polpa cítrica; silagem de milho com 20% de polpa cítrica; silagem de milho com 30% de polpa cítrica; silagem de milho com 40% de polpa cítrica e silagem de milho com 50% de polpa cítrica. O pH diminuiu linearmente com à inclusão de polpa cítrica, gerando valores distantes do considerado adequado (3,8 a 4,2). Por outro lado, é possível inferior que nem todos os parâmetros fermentativos foram comprometidos, uma vez que, com a inclusão de 33% de polpa cítrica, é possível estimar 30,82 g/kg total N. Com a utilização 45 de 49% de polpa cítrica, é possível obter 95,16 g/kg de proteína bruta. De 21% a 22% de polpa cítrica, foi obtido 549,89 g/kg de fibra em detergente neutro e 678,11 g/kg de nutrientes digestíveis totais. A inclusão de até 30% de polpa cítrica melhorará significativamente a composição química da silagem de milho, devido à redução nos valores de carboidrato estrutural e aumentos nos nutrientes digestíveis totais e proteína.

ABSTRACT The objective of this study was to evaluate the effects of including citrus pulp in maize silage on chemical composition and fermentation parameters. The experimental design was fully randomized with four replicates. Maize silage consisting of 0–50% citrus pulp was produced and analyzed. The pH linearly decreased with the increased inclusion of citrus pulp (3.49 at 50% citrus pulp), which is far below what is considered adequate (3.8–4.2). However, not all fermentation parameters were compromised. At 33% citrus pulp, we estimated 30.82 g/kg total nitrogen. At 49% citrus pulp, we estimated 95.16 g/kg of crude protein. At 21% and 22% citrus pulp, we estimated 549.89 g/kg of neutral detergent fiber and 678.11 g/kg of total digestible nutrients, respectively. Therefore, we conclude that the inclusion of up to 30% citrus pulp improves the complete chemical composition of maize silage owing to the reduction in structural carbohydrate values and increases in total digestible nutrient and protein content.

https://doi.org/10.1590/s1519-9940213502022

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