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Resumen Este artículo presenta las tablas de vida del mercado de seguros privados brasileño, BR-EMS 2021. Los datos, obtenidos de 23 grupos de seguros a lo largo de 15 años, totalizando 3,5 mil millones de registros, fueron corregidos usando una red neuronal con dos capas ocultas. Mediante la inferencia bayesiana para estimar los parámetros bajo la ley de mortalidad de Heligman-Pollard, las tablas obtenidas muestran que la población asegurada tiene tasas de mortalidad más bajas que la población general brasileña e incluso más bajas que las poblaciones nacionales de países desarrollados, como los Estados Unidos de Norteamérica. Además de la diferencia de género esperada en las tasas de mortalidad, hay una clara distinción entre las tablas de grupos de cobertura de riesgo y cobertura de sobrevivientes. Asimismo, se demuestra que las tablas regionales de población asegurada no presentan las conocidas discrepancias estructurales regionales en Brasil, lo que indica que participar de la población de asegurados está asociado con una protección contra la muerte más efectiva que otros factores como la región geográfica de residencia. brasileño BREMS BR EMS 2021 datos 2 1 años 35 3 5 3, registros ocultas HeligmanPollard, HeligmanPollard Heligman Pollard, Pollard Heligman-Pollard desarrollados Norteamérica sobrevivientes Asimismo Brasil residencia 202 20

Resumo Este artigo apresenta as tábuas de vida do mercado de seguros privados brasileiro, BR-EMS 2021. Os dados obtidos de 23 grupos seguradores ao longo de 15 anos, totalizando 3,5 bilhões de registros, foram corrigidos por meio de rede neural com duas camadas ocultas. Usando a inferência bayesiana para estimar os parâmetros sob a lei de mortalidade Heligman-Pollard, as tábuas obtidas mostram que a população segurada apresenta probabilidades de morte mais baixas do que a população brasileira em geral e até mesmo em relação a populações nacionais de países desenvolvidos, como os EUA. Além da esperada diferença de gênero nas taxas de mortalidade, há uma clara distância entre as probabilidades de morte dos grupos de cobertura de risco e cobertura de sobrevivência. Da mesma forma, é demonstrado que as tábuas regionais da população segurada não apresentam as discrepâncias regionais conhecidas no Brasil, indicando que fazer parte da população selecionada de segurados está associado a um fator de proteção mais eficaz do que outros fatores, como a região geográfica de residência. brasileiro BREMS BR EMS 2021 2 1 anos 35 3 5 3, registros ocultas HeligmanPollard, HeligmanPollard Heligman Pollard, Pollard Heligman-Pollard desenvolvidos EUA sobrevivência forma Brasil fatores residência 202 20

Abstract This article presents the Brazilian private insurance market’s actuarial life tables, BR- EMS 2021. Using Bayesian inference on the parameters of the Heligman- Pollard law of mortality and data from 23 insurance groups over 15 years, totaling 3.5 billion registers, the data were corrected through a two hidden-layer neural network. The resulting tables show that the insured population exhibits lower mortality rates than the general Brazilian population, even lower than the national populations of well-developed countries such as the USA. Moreover, besides the expected gender gap in mortality rates, there is a clear distance between the death and survivorship insurance coverage groups. Likewise, the insured population characteristics mitigate well-known regional structural discrepancies in the Brazilian population, indicating that being part of the selected population of insured individuals is thus associated with a more effective protection against death than other outstanding factors such as geographic region of residence. markets market s BR 2021 Heligman 2 1 years 35 3 5 3. registers hiddenlayer hidden layer network welldeveloped well developed USA Moreover Likewise wellknown known residence 202 20

https://doi.org/10.20947/s0102-3098a0252

Brazilian evidence-based guideline for screening, diagnosis, treatment, and follow-up of metabolic dysfunction-associated steatotic liver disease (MASLD) in adult individuals with overweight or obesity: A joint position statement from the Brazilian Society of Endocrinology and Metabolism (SBEM), Brazilian Society of Hepatology (SBH), and Brazilian Association for the Study of Obesity and Metabolic Syndrome (Abeso) evidencebased evidence based screening diagnosis treatment followup follow up dysfunctionassociated dysfunction associated MASLD (MASLD obesity SBEM, SBEM , (SBEM) SBH, SBH (SBH) Abeso (Abeso (SBEM (SBH
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Moreira, Rodrigo Oliveira

; Valerio, Cynthia Melissa

; Villela-Nogueira, Cristiane Alves

; Cercato, Cintia

; Gerchman, Fernando

; Lottenberg, Ana Maria Pita

; Godoy-Matos, Amélio Fernando

; Oliveira, Ricardo de Andrade

; Mello, Carlos Eduardo Brandão

; Álvares-da-Silva, Mário Reis

; Leite, Nathalie Carvalho

; Cotrim, Helma Pinchemel

; Parisi, Edison Roberto

; Silva, Giovanni Faria

; Miranda, Paulo Augusto Carvalho

; Halpern, Bruno

; Oliveira, Claudia Pinto

Archives of Endocrinology and Metabolism

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2023, Volume 67 N. 6 elocation e230123

Abstract: En | Text: En | PDF: En

ABSTRACT Introduction: Metabolic dysfunction-associated steatotic liver disease (MASLD), previously known as Nonalcoholic fatty liver disease (NAFLD), is one of the most common hepatic diseases in individuals with overweight or obesity. In this context, a panel of experts from three medical societies was organized to develop an evidence-based guideline on the screening, diagnosis, treatment, and follow-up of MASLD. Material and methods: A MEDLINE search was performed to identify randomized clinical trials, meta-analyses, cohort studies, observational studies, and other relevant studies on NAFLD. In the absence of studies on a certain topic or when the quality of the study was not adequate, the opinion of experts was adopted. Classes of Recommendation and Levels of Evidence were determined using prespecified criteria. Results: Based on the literature review, 48 specific recommendations were elaborated, including 11 on screening and diagnosis, 9 on follow-up, 14 on nonpharmacologic treatment, and 14 on pharmacologic and surgical treatment. Conclusions: A literature search allowed the development of evidence-based guidelines on the screening, diagnosis, treatment, and follow-up of MASLD in individuals with overweight or obesity. Introduction dysfunctionassociated dysfunction associated MASLD, , (MASLD) NAFLD, NAFLD (NAFLD) obesity context evidencebased evidence based diagnosis treatment followup follow up methods trials metaanalyses, metaanalyses meta analyses, analyses meta-analyses adequate adopted criteria Results review 4 elaborated 1 followup, up, Conclusions (MASLD (NAFLD

https://doi.org/10.20945/2359-4292-2023-0123

[SciELO Preprints] - Strengthening the surveillance and information activities is urgent and essential to reduce the transmission force of SARS-CoV-2
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Teixeira, Maria Glória Kerr, Ligia Regina Franco Sansigolo Ximenes, Ricardo Arraes de Alencar Almeida, Rosa Lívia Freitas de Ichihara, Maria Yury Albuquerque, Maria de Fátima Militão de Aquino, Estela M L Werneck, Guilherme Carmo, Eduardo Hage Medronho, Roberto Andrade Oliveira, Wanderson Kleber de Henriques, Claudio Maierovitch Pessanha Kendall, Carl Silva, Antônio Augusto Moura da Almeida-Filho, Naomar M. Souza, Wayner Vieira de Veras , Maria Amelia de Sousa Mascena Penna, Gerson Oliveira Silva , Gulnar Azevedo e Brandão Filho, Sinval Pinto Barreto, Maurício L.

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Publication date: 2021-08-17

Abstract: En Pt

N/A

https://doi.org/10.1590/1980-549720210049

Atypical presentation of COVID-19 with multi-organ involvement in a pediatric patient
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Martins-Filho, Paulo Ricardo

; Tavares, Carolina Santos

; Oliveira, Sheila Jaqueline Gomes dos Santos

; Santos, Patrícia Carla Nascimento dos

; Rodrigues, Marlon Brandam Brandão

; Santos, Victor Santana

; Leite, Débora Cristina Fontes

Revista da Associação Médica Brasileira

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jun 2021, Volume 67 N. 6 Pages 785 - 788

Abstract: En | Text: En | PDF: En

https://doi.org/10.1590/1806-9282.20200969 36 downloads

Covid-19 no nordeste do Brasil: entre o lockdown e o relaxamento das medidas de distanciamento social
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Ximenes, Ricardo Arraes de Alencar

; Albuquerque, Maria de Fatima Pessoa Militão de

; Martelli, Celina Maria Turchi

; Araújo, Thália Velho Barreto de

; Miranda Filho, Demócrito de Barros

; Souza, Wayner Vieira de

; Ichihara, Maria Yury Travassos

; Lira, Pedro Israel Cabral de

; Kerr, Ligia Regina Franco Sansigolo

; Aquino, Estela ML

; Silva, Antônio Augusto Moura da

; Almeida, Rosa Lívia Freitas de

; Kendall, Carl

; Pescarini, Julia M

; Brandão Filho, Sinval Pinto

; Almeida-Filho, Naomar

; Oliveira, Juliane Fonseca de

; Teles, Carlos

; Jorge, Daniel Cardoso Pereira

; Santana, Guilherme

; Gabrielli, Ligia

; Rodrigues, Moreno MS

; Silva, Natanael Jesus da

; Souza, Rafael Felipe da Silva

; Silva, Vivian Alessandra Ferreira da

; Barreto, Maurício Lima

Ciência & Saúde Coletiva

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apr 2021, Volume 26 N. 4 Pages 1441 - 1456

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Mesmo no período em que a pandemia de Covid-19 encontrava-se em crescimento no Nordeste do Brasil, iniciou-se a adoção de medidas de flexibilização do distanciamento social. O objetivo do estudo é o de avaliar a pertinência das propostas de flexibilização, tomando-se em conta a situação da pandemia em cada local e o momento em que foram adotadas. Tendo como referência as diretrizes da OMS, foram construídos e analisados indicadores operacionais para cada diretriz, no contexto da região Nordeste. Para análise do comportamento da epidemia, conforme indicadores selecionados, foram usadas técnicas de Joinpoint Trend Analysis, mapas de calor, razão de taxas e comparação da tendência temporal entre capitais e interior dos estados. O pico do crescimento semanal ocorreu em maio-julho/2020 (semanas epidemiológicas 19 a 31). Na maioria das capitais não se observou tendência decrescente simultânea do número de casos e óbitos nos 14 dias prévios à flexibilização. Em todos os estados o quantitativo de testes realizados foi insuficiente. Na semana epidemiológica 24 os percentuais estaduais de ocupação de leitos de UTI/Covid-19 foram próximos ou superiores 70%. A situação epidemiológica das nove capitais dos estados do Nordeste, no momento em que a decisão de flexibilização foi tomada, mostra que nenhuma delas atendia aos critérios e parâmetros recomendados pela OMS.

Abstract Even in the period when the Covid-19 pandemic was on the rise in the Northeast of Brazil, the relaxation of social distancing measures was introduced. The scope of the study is to assess, in the light of the epidemiological-sanitary situation in the region, the suitability of relaxation of social distancing measures. Based on the WHO guidelines for relaxation of social distancing, operational indicators were created and analyzed for each guideline in the context of the Northeast. To analyze the behavior of the epidemic, according to selected indicators, Joinpoint trend analysis techniques, heat maps, rate ratios and time trends between capitals and the state interior were compared. The weekly growth peak of the epidemic occurred in May-July 2020 (epidemiological weeks 19 to 31). In most capitals, there was no simultaneous downward trend in the number of cases and deaths in the 14 days prior to flexibilization. In all states the number of tests performed was insufficient. In epidemiological week 24, the state percentages of ICU/Covid-19 bed occupancy were close to or above 70%. The epidemiological situation of the nine Northeastern state capitals analyzed here did not meet criteria and parameters recommended by the World Health Organization for the relaxation of social distancing measures.

https://doi.org/10.1590/1413-81232021264.39422020 2043 downloads

Fortalecer as atividades de informação e vigilância epidemiológica é essencial e urgente para reduzir a força de transmissão do SARS-CoV-2
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Teixeira, Maria Glória

; Kerr, Ligia Regina Franco Sansigolo

; Ximenes, Ricardo Arraes de Alencar

; Almeida, Rosa Lívia Freitas de

; Ichihara, Maria Yury

; Albuquerque, Maria de Fátima Militão de

; Aquino, Estela M L

; Werneck, Guilherme Loureiro

; Carmo, Eduardo Hage

; Medronho, Roberto Andrade

; Oliveira, Wanderson Kleber de

; Henriques, Claudio Maierovitch Pessanha

; Kendall, Carl

; Silva, Antônio Augusto Moura da

; Almeida Filho, Naomar Monteiro

; Souza, Wayner Vieira de

; Veras, Maria Amelia de Sousa Mascena

; Penna, Gerson Oliveira

; Silva, Gulnar Azevedo e

; Brandão Filho, Sinval Pinto

; Barreto, Maurício Lima

Revista Brasileira de Epidemiologia

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2021, Volume 24 elocation e210049

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.1590/1980-549720210049 69 downloads

Brazilian Society of Rheumatology 2020 guidelines for psoriatic arthritis
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Carneiro, Sueli

; Palominos, Penelope Esther

; Anti, Sônia Maria Alvarenga

; Assad, Rodrigo Luppino

; Gonçalves, Rafaela Silva Guimarães

; Chiereghin, Adriano

; Lyrio, Andre Marun

; Ximenes, Antônio Carlos

; Saad, Carla Gonçalves

; Gonçalves, Célio Roberto

; Kohem, Charles Lubianca

; Marques, Cláudia Diniz Lopes

; Schainberg, Cláudia Goldenstein

; Meirelles, Eduardo de Souza

; Resende, Gustavo Gomes

; Pieruccetti, Lenise Brandao

; Keiserman, Mauro Waldemar

; Yazbek, Michel Alexandre

; Sampaio-Barros, Percival Degrava

; Lage, Ricardo da Cruz

; Bonfiglioli, Rubens

; Oliveira, Thauana Luíza

; Azevedo, Valderílio Feijó

; Bianchi, Washington Alves

; Bernardo, Wanderley Marques

; Simões, Ricardo dos Santos

; Pinheiro, Marcelo de Medeiros

; Campanholo, Cristiano Barbosa

Advances in Rheumatology

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2021, Volume 61 elocation 69

Abstract: En | Text: En | PDF: En

Abstract Psoriatic arthritis (PsA) is a chronic and systemic immune disease characterized by inflammation of peripheral and/ or axial joints and entheses in patients with psoriasis (PsO). Extra-articular and extracutaneous manifestations and numerous comorbidities can also be present. These recommendations replace the previous version published in May 2013. A systematic review of the literature retrieved 191 articles that were used to formulate 12 recommendations in response to 12 clinical questions, divided into 4 sections: diagnosis, non-pharmacological treatment, conventional drug therapy and biologic therapy. These guidelines provide evidence-based information on the clinical management for PsA patients. For each recommendation, the level of evidence (highest available), degree of strength (Oxford) and degree of expert agreement (interrater reliability) are reported.

https://doi.org/10.1186/s42358-021-00219-y

10.

Brazilian recommendations for the use of nonsteroidal anti-inflammatory drugs in patients with axial spondyloarthritis
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Lage, Ricardo da Cruz

; Marques, Claudia Diniz Lopes

; Oliveira, Thauana Luiza

; Resende, Gustavo Gomes

; Kohem, Charles Lubianca

; Saad, Carla Gonçalves

; Ximenes, Antônio Carlos

; Gonçalves, Célio Roberto

; Bianchi, Washington Alves

; Meirelles, Eduardo de Souza

; Keiserman, Mauro Waldemar

; Chiereghin, Adriano

; Campanholo, Cristiano Barbosa

; Lyrio, André Marun

; Schainberg, Cláudia Goldenstein

; Pieruccetti, Lenise Brandao

; Yazbek, Michel Alexandre

; Palominos, Penelope Esther

; Goncalves, Rafaela Silva Guimarães

; Assad, Rodrigo Luppino

; Bonfiglioli, Rubens

; Lima, Sônia Maria Alvarenga Anti Loduca

; Carneiro, Sueli

; Azevedo, Valderílio Feijó

; Albuquerque, Cleandro Pires

; Bernardo, Wanderley Marques

; Sampaio-Barros, Percival Degrava

; Pinheiro, Marcelo de Medeiros

Advances in Rheumatology

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2021, Volume 61 elocation 4

Abstract: En | Text: En | PDF: En

Abstract Spondyloarthritis (SpA) is a group of chronic inflammatory systemic diseases characterized by axial and/or peripheral joints inflammation, as well as extra-articular manifestations. Over some decades, nonsteroidal anti-inflammatory drugs (NSAIDs) have been the basis for the pharmacological treatment of patients with axial spondyloarthritis (axSpA). However, the emergence of the immunobiologic agents brought up the discussion about the role of NSAIDs in the management of these patients. The objective of this guideline is to provide recommendations for the use of NSAIDs for the treatment of axSpA. A panel of experts from the Brazilian Society of Rheumatology conducted a systematic review and meta-analysis of randomized clinical trials for 15 predefined questions. The Grading of Recommendations, Assessment, Development and Evaluation methodology to assess the quality of evidence and formulate recommendations were used, and at least 70% agreement of the voting panel was needed. Fourteen recommendations for the use of NSAIDs in the treatment of patients with axSpA were elaborated. The purpose of these recommendations is to support clinicians’ decision making, without taking out his/her autonomy when prescribing for an individual patient.

https://doi.org/10.1186/s42358-020-00160-6 505 downloads

11.

Implications for Clinical Practice from a Multicenter Survey of Heart Failure Management Centers
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Bocchi, Edimar Alcides

; Moreira, Henrique Turin

; Nakamuta, Juliana Sanajotti

; Simões, Marcus Vinicius

; Casas, Alberto de Almeida Las

; Costa, Altamiro Reis da

; Assis, Amberson Vieira de

; Durães, André Rodrigues

; Pereira-Barretto, Antonio Carlos

; Ravessa, Antonio Delduque de Araujo

; Macedo, Ariane Vieira Scarlatelli

; Biselli, Bruno

; Pinto, Carolina Maria Nogueira

; Filho, Conrado Roberto Hoffmann

; Costantini, Costantino Roberto

; Almeida, Dirceu Rodrigues

; Santos Jr, Edval Gomes dos

; Soliva Junior, Erwin

; Figueiredo, Estevão Lanna

; Albuquerque, Felipe Neves de

; Paulitsch, Felipe

; Neuenschwander, Fernando Carvalho

; Figueiredo Neto, José Albuquerque de

; Brito, Flavio de Souza

; Lopes, Heno Ferreira

; Villacorta, Humberto

; Souza Neto, João David de

; Sepulveda, João Mariano

; Ayoub, José Carlos Aidar

; Vilela-Martin, José F.

; Cardoso, Juliano Novaes

; Uemura, Laercio

; Moura, Lidia Zytynski

; Maia, Lilia Nigro

; Oliveira, Lucia Brandão de

; Maia, Lucimir

; Silva, Luís Beck da

; Gowdak, Luís Henrique Wolff

; Danzmann, Luiz Claudio

; Andrade, Marcus

; Braile-Sternieri, Maria Christiane Valeria Braga

; Moreira, Maria da Consolação Vieira

; França Neto, Olimpio R

; Filho, Otavio Rizzi Coelho

; Esteves, Paulo Frederico

; Raupp-da-Rosa, Priscila

; Silva, Ricardo Jorge de Queiroz e

; Mourilhe-Rocha, Ricardo

; Viégas, Ruy Felipe Melo

; Rassi, Salvador

; Mangili, Sandrigo

; Kaiser, Sergio Emanuel

; Martins, Silvia Marinho

; Kawabata, Vitor Sergio

Clinics

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2021, Volume 76 elocation e1991

Abstract: En | Text: En | PDF: En

OBJECTIVES: This observational, cross-sectional study based aimed to test whether heart failure (HF)-disease management program (DMP) components are influencing care and clinical decision-making in Brazil. METHODS: The survey respondents were cardiologists recommended by experts in the field and invited to participate in the survey via printed form or email. The survey consisted of 29 questions addressing site demographics, public versus private infrastructure, HF baseline data of patients, clinical management of HF, performance indicators, and perceptions about HF treatment. RESULTS: Data were obtained from 98 centers (58% public and 42% private practice) distributed across Brazil. Public HF-DMPs compared to private HF-DMP were associated with a higher percentage of HF-DMP-dedicated services (79% vs 24%; OR: 12, 95% CI: 94-34), multidisciplinary HF (MHF)-DMP [84% vs 65%; OR: 3; 95% CI: 1-8), HF educational programs (49% vs 18%; OR: 4; 95% CI: 1-2), written instructions before hospital discharge (83% vs 76%; OR: 1; 95% CI: 0-5), rehabilitation (69% vs 39%; OR: 3; 95% CI: 1-9), monitoring (44% vs 29%; OR: 2; 95% CI: 1-5), guideline-directed medical therapy-HF use (94% vs 85%; OR: 3; 95% CI: 0-15), and less B-type natriuretic peptide (BNP) dosage (73% vs 88%; OR: 3; 95% CI: 1-9), and key performance indicators (37% vs 60%; OR: 3; 95% CI: 1-7). In comparison to non- MHF-DMP, MHF-DMP was associated with more educational initiatives (42% vs 6%; OR: 12; 95% CI: 1-97), written instructions (83% vs 68%; OR: 2: 95% CI: 1-7), rehabilitation (69% vs 17%; OR: 11; 95% CI: 3-44), monitoring (47% vs 6%; OR: 14; 95% CI: 2-115), GDMT-HF (92% vs 83%; OR: 3; 95% CI: 0-15). In addition, there were less use of BNP as a biomarker (70% vs 84%; OR: 2; 95% CI: 1-8) and key performance indicators (35% vs 51%; OR: 2; 95% CI: 91,6) in the non-MHF group. Physicians considered changing or introducing new medications mostly when patients were hospitalized or when observing worsening disease and/or symptoms. Adherence to drug treatment and non-drug treatment factors were the greatest medical problems associated with HF treatment. CONCLUSION: HF-DMPs are highly heterogeneous. New strategies for HF care should consider the present study highlights and clinical decision-making processes to improve HF patient care.

https://doi.org/10.6061/clinics/2021/e1991 870 downloads

12.

Covid-19 no nordeste do Brasil: entre o lockdown e o relaxamento das medidas de distanciamento social
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Ximenes, Ricardo Arraes de Alencar

; Albuquerque, Maria de Fatima Pessoa Militão de

; Martelli, Celina Maria Turchi

; Araújo, Thália Velho Barreto de

; Miranda Filho, Demócrito de Barros

; Souza, Wayner Vieira de

; Ichihara, Maria Yury Travassos

; Lira, Pedro Israel Cabral de

; Kerr, Ligia Regina Franco Sansigolo

; Aquino, Estela ML

; Silva, Antônio Augusto Moura da

; Almeida, Rosa Lívia Freitas de

; Kendall, Carl

; Pescarini, Julia M

; Brandão Filho, Sinval Pinto

; Almeida-Filho, Naomar

; Oliveira, Juliane Fonseca de

; Teles, Carlos

; Jorge, Daniel Cardoso Pereira

; Santana, Guilherme

; Gabrielli, Ligia

; Rodrigues, Moreno MS

; Silva, Natanael Jesus da

; Souza, Rafael Felipe da Silva

; Silva, Vivian Alessandra Ferreira da

; Barreto, Maurício Lima

Ciência & Saúde Coletiva

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2021, Volume 26 N. 4 Pages 1441 - 1456

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.1590/1413-81232021264.39422020

13.

COVID-19 no Nordeste brasileiro: sucessos e limitações nas respostas dos governos dos estados
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Kerr, Ligia

; Kendall, Carl

; Silva, Antônio Augusto Moura da

; Aquino, Estela Maria L

; Pescarini, Julia M

; Almeida, Rosa Lívia Freitas de

; Ichihara, Maria Yury

; Oliveira, Juliane F

; Araújo, Thália Velho Barreto de

; Santos, Carlos Teles

; Jorge, Daniel Cardoso Pereira

; Miranda Filho, Demócrito de Barros

; Santana, Guilherme

; Gabrielli, Ligia

; Albuquerque, Maria de Fatima Pessoa Militão de

; Almeida-Filho, Naomar

; Silva, Natanael de Jesus

; Souza, Rafael

; Ximenes, Ricardo Arraes de Alencar

; Martelli, Celina Maria Turchi

; Brandão Filho, Sinval Pinto

; Souza, Wayner Vieira de

; Barreto, Maurício Lima

Ciência & Saúde Coletiva

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oct 2020, Volume 25 Suppl. 2 Pages 4099 - 4120

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo No Brasil, a pandemia da COVID-19 tem sido severa nos estados das regiões mais pobres, como o Nordeste. A falta de políticas nacionais para controle da pandemia levou as autoridades estaduais e municipais a implementarem medidas de saúde pública. O objetivo deste estudo é mostrar o efeito dessas medidas na epidemia. A maior incidência da COVID-19 entre os nove estados do Nordeste foi registrada em Sergipe, Paraíba e Ceará. O Piauí, a Paraíba e Ceará foram os que mais testaram. Muitos estados apresentavam alta proporção de pessoas em trabalho informal. Estados com aeroportos internacionais tiveram importante papel na entrada e disseminação inicial do vírus, em especial o Ceará. Todos os estados aplicaram medidas de distanciamento social, proibição de eventos públicos e fechamento de unidades de ensino. As respostas foram o aumento significativo de distanciamento social, em especial Ceará e Pernambuco, a queda do número de reprodução (Rt) e a separação da curva dos casos observados da curva dos casos esperados sem as intervenções não medicamentosas em todos os estados. A pobreza, a desigualdade e as altas taxas de trabalho informal fornecem pistas do porquê da intensidade da COVID-19 na região. Por outro lado, as medidas de mitigação tomadas precocemente pelos governantes amenizaram os efeitos da pandemia.

Abstract The COVID-19 pandemic has been most severe in the poorest regions of Brazil, such as the states of the Northeast Region. The lack of national policies for pandemic control forced state and municipal authorities to implement public health measures. The aim of this study is to show the effect of these measures on the epidemic. The highest incidence of COVID-19 among the nine states in the Northeast was recorded in Sergipe, Paraíba and Ceará. Piauí, Paraíba and Ceará were the states that most tested. Factors associated with transmission included the high proportion of people in informal work. States with international airports played an important role in the entry of the virus and the initial spread, especially Ceará. All states applied social distancing measures, banned public events and closed schools. The response was a significant increase in social distancing, especially in Ceará and Pernambuco, a decline in the reproduction rate (Rt), and a separation of the curve of observed cases versus expected cases if the non-pharmacological interventions had not been implemented in all states. Poverty, inequality, and the high rates of informal work provide clues to the intensity of COVID-19 in the region. On the other hand, the measures taken early by the governments mitigated the effects of the pandemic.

https://doi.org/10.1590/1413-812320202510.2.28642020 7489 downloads

14.

Neuroprotective Effect of Isobenzofuranones on Hydrogen Peroxide-Mediated Redox Imbalance in Primary Cultures of Hippocampal Neurons
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Ribeiro, Iára Mariana Léllis

; Pereira, Wagner Luiz

; Nogueira, Leonardo Brandão

; Oliveira, Laser Antônio Machado

; Teixeira, Róbson Ricardo

; Nogueira, Katiane de Oliveira Pinto Coelho

Brazilian Archives of Biology and Technology

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2020, Volume 63 elocation e20190072

Abstract: En | Text: En | PDF: En

Abstract In live organisms, there is a balance between the production of reactive oxygen species (ROS) and their neutralization. The increased level of these species leads to a condition called redox imbalance. The aim of this study was to evaluate the protective action of isobenzofuranones in primary cultures of hippocampal neurons subjected to redox imbalance. To accomplish this, MTT and LIVE/DEAD assays were initially performed. In the cultures pretreated with isobenzofuranones 1 and 2, there was a higher number of live cells when compared to that in the untreated ones. Regarding redox imbalance, there was a significant increase in the intracellular levels of ROS. The cultures pretreated with isobenzofuranones showed a reduction in ROS levels. Lipid peroxidation caused by oxidative damage was significantly reduced in the cultures pretreated with isobenzofuranones 1 and 2. Taken together, these data show the ability of isobenzofuranones 1 and 2 to significantly minimize cytotoxicity, cell death, intracellular levels of ROS and lipid peroxidation induced by redox imbalance. These results suggest that isobenzofuranones 1 and 2 represent a possible alternative therapy for the neurodegenerative disturbances that are triggered by ROS production increases.

https://doi.org/10.1590/1678-4324-2020190072 648 downloads

15.

The Brazilian Society of Rheumatology guidelines for axial spondyloarthritis – 2019
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Resende, Gustavo Gomes

; Meirelles, Eduardo de Souza

; Marques, Cláudia Diniz Lopes

; Chiereghin, Adriano

; Lyrio, Andre Marun

; Ximenes, Antônio Carlos

; Saad, Carla Gonçalves

; Gonçalves, Célio Roberto

; Kohem, Charles Lubianca

; Schainberg, Cláudia Goldenstein

; Campanholo, Cristiano Barbosa

; Bueno Filho, Júlio Silvio de Sousa

; Pieruccetti, Lenise Brandao

; Keiserman, Mauro Waldemar

; Yazbek, Michel Alexandre

; Palominos, Penelope Esther

; Goncalves, Rafaela Silva Guimarães

; Lage, Ricardo da Cruz

; Assad, Rodrigo Luppino

; Bonfiglioli, Rubens

; Anti, Sônia Maria Alvarenga

; Carneiro, Sueli

; Oliveira, Thauana Luíza

; Azevedo, Valderílio Feijó

; Bianchi, Washington Alves

; Bernardo, Wanderley Marques

; Pinheiro, Marcelo de Medeiros

; Sampaio-Barros, Percival Degrava

Advances in Rheumatology

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2020, Volume 60 elocation 19

Abstract: En | Text: En | PDF: En

Abstract Spondyloarthritis is a group of chronic inflammatory systemic diseases characterized by axial and/or peripheral joints inflammation, as well as extra-articular manifestations. The classification axial spondyloarthritis is adopted when the spine and/or the sacroiliac joints are predominantly involved. This version of recommendations replaces the previous guidelines published in May 2013. A systematic literature review was performed, and two hundred thirty-seven studies were selected and used to formulate 29 recommendations answering 15 clinical questions, which were divided into four sections: diagnosis, non-pharmacological therapy, conventional drug therapy and biological therapy. For each recommendation the level of evidence supporting (highest available), the strength grade according to Oxford, and the degree of expert agreement (inter-rater reliability) is informed. These guidelines bring evidence-based information on clinical management of axial SpA patients, including, diagnosis, treatment, and prognosis.

https://doi.org/10.1186/s42358-020-0116-2 1116 downloads

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