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au:Oliveira, Maria da Conceição F. de

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Semisynthesis and Cytotoxic Activities of Novel Oxime Ester Derivatives of the Diterpene Stemodin
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Oliveira, José Augusto C. de

; Alves Filho, Carlos José

; Lima, Antônio Marcelo A.

; Pessoa, Cláudia do Ó

; Oliveira, Fátima de Cássia E. de

; Miranda, Fátima N.

; Mattos, Marcos Carlos de

; Oliveira, Maria Conceição F.

; Mafezoli, Jair

; Barbosa, Francisco Geraldo

Journal of the Brazilian Chemical Society

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2024, Volume 35 N. 6 elocation e-20230193

Abstract: En | Text: En | PDF: En

Stemodin (1) is a diterpene produced by Stemodia maritima L. (Scrophulariaceae) and shows antiviral and tumor cell proliferation inhibitory activities. Chemical modifications of 1 were performed to produce the known stemodinone (2), two new stemodinone oximes, Z (3) and E (4), and seven new oxime esters derivatives (5, 6, 7, 8, 9, 10, and 11). All derivatives were evaluated for their cytotoxic activity in HL60 (promyelocytic leukemia), SNB-19 (astrocytoma), HCT-116 (colon carcinoma), and PC3 (prostate) human cancer cell lines, and L929 (healthy murine cells). Oximes 3 and 4 showed lower cytotoxic values than 1 against all cancer cell lines tested. However, esters 9 and 10 exhibited cell growth inhibition percentages higher than 1 against PC3, SNB-19, and HCT-116 cancer cell lines, ranging from 62.96 to 94.27%. Many of these values exceed that presented by doxorubicin (66.05-86.87%). All compounds showed no cytotoxic effect on healthy cells at the tested concentration of 25 µg mL-1. (1 L Scrophulariaceae (Scrophulariaceae activities 2, 2 , (2) oximes (3 4, (4) 5, 5 (5 6 7 8 11. 11 . 11) HL HL6 promyelocytic leukemia, leukemia leukemia) SNB19 SNB 19 SNB-1 astrocytoma, astrocytoma (astrocytoma) HCT116 HCT 116 HCT-11 colon carcinoma, carcinoma carcinoma) PC prostate (prostate L92 cells. cells) However SNB19, 19, 6296 62 96 62.9 9427 94 27 94.27% 66.0586.87%. 66058687 66.05 86.87% 66 05 86 87 (66.05-86.87%) mL1. mL1 mL 1. mL-1 ( (2 (4 SNB1 SNB- (astrocytoma HCT11 HCT-1 L9 629 62. 942 94.27 0586 66.0586.87% 6605868 6605 66.0 8687 86.87 0 (66.05-86.87% mL- HCT1 HCT- 94.2 058 66.0586.87 660586 660 66. 868 86.8 (66.05-86.87 94. 66.0586.8 66058 86. (66.05-86.8 66.0586. (66.05-86. 66.0586 (66.05-86 66.058 (66.05-8 (66.05- (66.05 (66.0 (66. (66 (6

https://doi.org/10.21577/0103-5053.20230193

Brazilian Research Consortium on Obsessive-Compulsive Spectrum Disorders guidelines for the treatment of adult obsessive-compulsive disorder. Part I: pharmacological treatment ObsessiveCompulsive Obsessive Compulsive obsessivecompulsive obsessive compulsive disorder I
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de Oliveira, Marcos Vinícius Sousa

; de Barros, Pedro Macul Ferreira

; de Mathis, Maria Alice

; Boavista, Rodrigo

; Chacon, Priscila

; Echevarria, Marco Antonio Nocito

; Ferrão, Ygor Arzeno

; Vattimo, Edoardo Felippo de Queiroz

; Lopes, Antônio Carlos

; Torres, Albina Rodrigues

; Diniz, Juliana Belo

; Fontenelle, Leonardo F.

; Rosário, Maria Conceição do

; Shavitt, Roseli Gedanke

; Miguel, Eurípedes Constantino

; da Silva, Renata de Melo Felipe

; Costa, Daniel Lucas da Conceição

Brazilian Journal of Psychiatry

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apr 2023, Volume 45 N. 2 Pages 146 - 161

Abstract: En | Text: En | PDF: En

Objectives: To summarize evidence-based pharmacological treatments and provide guidance on clinical interventions for adult patients with obsessive-compulsive disorder (OCD). Methods: The American Psychiatric Association (APA) guidelines for the treatment of OCD (2013) were updated with a systematic review assessing the efficacy of pharmacological treatments for adult OCD, comprising monotherapy with selective serotonin reuptake inhibitors (SSRIs), clomipramine, serotonin and norepinephrine reuptake inhibitors (SNRIs), and augmentation strategies with clomipramine, antipsychotics, and glutamate-modulating agents. We searched for the literature published from 2013-2020 in five databases, considering the design of the study, primary outcome measures, types of publication, and language. Selected articles had their quality assessed with validated tools. Treatment recommendations were classified according to levels of evidence developed by the American College of Cardiology and the American Heart Association (ACC/AHA). Results: We examined 57 new studies to update the 2013 APA guidelines. High-quality evidence supports SSRIs for first-line pharmacological treatment of OCD. Moreover, augmentation of SSRIs with antipsychotics (risperidone, aripiprazole) is the most evidence-based pharmacological intervention for SSRI-resistant OCD. Conclusion: SSRIs, in the highest recommended or tolerable doses for 8-12 weeks, remain the first-line treatment for adult OCD. Optimal augmentation strategies for SSRI-resistant OCD include low doses of risperidone or aripiprazole. Pharmacological treatments considered ineffective or potentially harmful, such as monotherapy with antipsychotics or augmentation with ketamine, lamotrigine, or N-acetylcysteine, have also been detailed. Objectives evidencebased based obsessivecompulsive obsessive compulsive . (OCD) Methods (APA (2013 , (SSRIs) clomipramine SNRIs, SNRIs (SNRIs) glutamatemodulating glutamate modulating agents 20132020 2020 2013-202 databases study measures publication language tools ACC/AHA. ACCAHA ACC/AHA ACC AHA (ACC/AHA) Results 5 201 Highquality High firstline first line Moreover risperidone, (risperidone aripiprazole SSRIresistant SSRI resistant Conclusion 812 8 12 8-1 weeks harmful ketamine lamotrigine Nacetylcysteine, Nacetylcysteine N acetylcysteine, acetylcysteine N-acetylcysteine detailed (OCD (201 (SSRIs (SNRIs 2013202 202 2013-20 (ACC/AHA 20 81 1 8- (20 201320 2013-2 2 (2 20132 2013- (

https://doi.org/10.47626/1516-4446-2022-2891

Atualização de Tópicos Emergentes da Diretriz Brasileira de Insuficiência Cardíaca – 2021
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Marcondes-Braga, Fabiana G.

; Moura, Lídia Ana Zytynski

; Issa, Victor Sarli

; Vieira, Jefferson Luis

; Rohde, Luis Eduardo

; Simões, Marcus Vinícius

; Fernandes-Silva, Miguel Morita

; Rassi, Salvador

; Alves, Silvia Marinho Martins

; Albuquerque, Denilson Campos de

; Almeida, Dirceu Rodrigues de

; Bocchi, Edimar Alcides

; Ramires, Felix José Alvarez

; Bacal, Fernando

; Rossi Neto, João Manoel

; Danzmann, Luiz Claudio

; Montera, Marcelo Westerlund

; Oliveira Junior, Mucio Tavares de

; Clausell, Nadine

; Silvestre, Odilson Marcos

; Bestetti, Reinaldo Bulgarelli

; Bernadez-Pereira, Sabrina

; Freitas Jr, Aguinaldo F.

; Biolo, Andréia

; Barretto, Antonio Carlos Pereira

; Jorge, Antônio José Lagoeiro

; Biselli, Bruno

; Montenegro, Carlos Eduardo Lucena

; Santos Júnior, Edval Gomes dos

; Figueiredo, Estêvão Lanna

; Fernandes, Fábio

; Silveira, Fabio Serra

; Atik, Fernando Antibas

; Brito, Flávio de Souza

; Souza, Germano Emílio Conceição

; Ribeiro, Gustavo Calado de Aguiar

; Villacorta, Humberto

; Souza Neto, João David de

; Goldraich, Livia Adams

; Beck-da-Silva, Luís

; Canesin, Manoel Fernandes

; Bittencourt, Marcelo Imbroinise

; Bonatto, Marcely Gimenes

; Moreira, Maria da Consolação Vieira

; Avila, Mônica Samuel

; Coelho Filho, Otavio Rizzi

; Schwartzmann, Pedro Vellosa

; Mourilhe-Rocha, Ricardo

; Mangini, Sandrigo

; Ferreira, Silvia Moreira Ayub

; Figueiredo Neto, José Albuquerque de

; Mesquita, Evandro Tinoco

Arquivos Brasileiros de Cardiologia

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jun 2021, Volume 116 N. 6 Pages 1174 - 1212

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.36660/abc.20210367 3168 downloads

Aspergillus niger: A Hundred Years of Contribution to the Natural Products Chemistry
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Lima, Mary Anne S.

; Oliveira, Maria da Conceição F. de

; Pimenta, Antônia T. Á.

; Uchôa, Paula K. S.

Journal of the Brazilian Chemical Society

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oct 2019, Volume 30 N. 10 Pages 2029 - 2059

Abstract: En | Text: En | PDF: En

Aspergillus niger is a phytopathogenic fungus responsible for the plant disease called “black mold”, and it is considered the most versatile microorganism for producing acids, proteins, and enzymes of industrial value, besides a variety of compounds of pharmacological interest. This review presents a century of contribution of A. niger in the natural products chemistry under two different perspectives: (i) an overview of the structural diversity of secondary metabolites produced by A. niger from different habitats and their biological activities; (ii) a general discussion of the enzymatic potential of A. niger on the selective biotransformation of terpenes, highlighting the most uncommon microbial transformations.

https://doi.org/10.21577/0103-5053.20190080 2452 downloads

Reply of the authors of the Continuing Medical Education article to Dr. Jaison Barreto and Dr. Laila Laguiche
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Cruz, Rossilente Conceiçao

; Bührer-Sékula, Samira

; Penna, Maria Lúcia F.

; Penna, Gerson de Oliveira

; Talhari, Sinésio

Anais Brasileiros de Dermatologia

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aug 2018, Volume 93 N. 4 Pages 625 - 626

Abstract: En | Text: En | PDF: En

https://doi.org/10.1590/abd1806-4841.201893404 1368 downloads

New flavone and other compounds from Tephrosia egregia: assessing the cytotoxic effect on human tumor cell lines
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Teixeira, Maria V.S.

; Lima, Jefferson Q.

; Pimenta, Antônia T.A.

; Silva, Francisca R.L. da

; Oliveira, Maria da Conceição F. de

; Pereira, Italo G.

; Costa-Junior, Dilailson C.

; Ribeiro, Paulo R.V.

; Santiago, Gilvandete M.P.

; Lima, Mary Anne S.

; Braz-Filho, Raimundo

; Bezerra, Mirna M.

; Montenegro, Raquel C.

; Rocha, Danilo D.

; Moraes, Maria Elisabete A. de

; Medeiros, Aline C. de

; Arriaga, Angela M.C.

Revista Brasileira de Farmacognosia

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jun 2018, Volume 28 N. 3 Pages 333 - 338

Abstract: En | Text: En | PDF: En

ABSTRACT The organic extracts from stems, roots and leaves of Tephrosia egregia Sandwith, Fabaceae, provided a new flavone, 5-hydroxy-8-(1",2"-epoxy-3"-hydroxy-3"-methylbutyl)-7-methoxyflavone (1), in addition to eleven known compounds: pongaflavone (2), praecansone B (3), 12a-hydroxyrotenone (4), praecansone A, 2',6'-dimethoxy-4',5'-(2",2"-dimethyl)-pyranochalcone, pongachalcone, maackiain, β-sistosterol and its glucoside, p-cumaric acid and cinnamic acid. The structures of all compounds were established on the basis of spectroscopic methods, mainly 1D and 2D NMR and HRESIMS, involving comparison with literature data. Cytotoxicity of compounds 1–4 was evaluated against AGP-01 (cancerous ascitic fluid), HCT-116 (colon adenocarcinoma), HL-60 (leukemia), PC-3 (prostate carcinoma), SF-295 (glioblastoma) and SKMEL 28 (melanoma) cell lines.

https://doi.org/10.1016/j.bjp.2018.03.008 525 downloads

Leprosy: current situation, clinical and laboratory aspects, treatment history and perspective of the uniform multidrug therapy for all patients
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Cruz, Rossilene Conceição da Silva

; Bührer-Sékula, Samira

; Penna, Maria Lúcia F.

; Penna, Gerson Oliveira

; Talhari, Sinésio

Anais Brasileiros de Dermatologia

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dec 2017, Volume 92 N. 6 Pages 761 - 773

Abstract: En | Text: En | PDF: En

Abstract: In this review, the most relevant and current epidemiological data, the main clinical, laboratory and therapeutical aspects of leprosy are presented. Detailed discussion of the main drugs used for leprosy treatment, their most relevant adverse effects, evolution of the therapeutic regimen, from dapsone as a monotherapy to the proposed polychemotherapy by World Health Organization (WHO) can be found in this CME. We specifically highlight the drug acceptability, reduction in treatment duration and the most recent proposal of a single therapeutic regimen, with a fixed six months duration, for all clinical presentations, regardless of their classification.

https://doi.org/10.1590/abd1806-4841.20176724 4018 downloads

NEW SEMISYNTHETIC DERIVATIVES OF A BENZYLISOTHIOCYANATE ISOLATED FROM Moringa oleifera AND EVALUATION OF THEIR CYTOTOXIC ACTIVITY
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Almeida, Diana Kelly C. de

; Silva, Marcos R. da

; Oliveira, Maria Conceição F. de

; Mafezoli, Jair

; Mattos, Marcos C. de

; Moura, Andréa F.

; Moraes Filho, Manoel O.

; Barbosa, Francisco G.

Química Nova

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oct 2017, Volume 40 N. 10 Pages 1186 - 1190

Abstract: En | Text: En | PDF: En

From the natural product 4-(4'-O-acetyl-α-L-rhamnosyloxy)benzylisothiocyanate (1), isolated from the flowers of Moringa oleifera Lam (Moringaceae), four new semisynthetic derivatives, N-[4-(4'-O-acetyl-α-L-rhamnosyloxy)benzyl]-2-(pyridinil-4-carbonil)hydrazine-1-carbothioamide (3), 4-(4'-O-acetyl-2',3'-dimesyloxy-α-L-rhamnosyloxy)benzylisothiocyanate (4), N-[(4'-O-acetyl-α-L-rhamnosyloxy)benzyl]hydrazinecarbothioamide (5), 4-[4'-O-acetyl-2',3'-O-bis(decanoiloxy)-α-L-rhamnosyloxy]benzylisothiocianate (6), and the known compound 4-(2',3',4'-O-triacetyl-α-L-rhamnosyloxy)benzylisothiocyanate (2), were obtained. All compounds were tested for their cytotoxicity against the tumor cell lines SF-295, HL-60, HCT-116 e PC-3. The natural product 1 and the semisynthetic derivatives 2 and 4 were the most active compounds (IC50 from16.0 to 3.7 µmol L-1) against all tumor cell lines.

https://doi.org/10.21577/0100-4042.20170132 888 downloads

Regioselective preparation of thiamphenicol esters through lipase-catalyzed processes
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Silva, Marcos R. da

; Montenegro, Tasso G. C.

; Mattos, Marcos C. de

; Oliveira, Maria da Conceição F. de

; Lemos, Telma L. G. de

; Gonzalo, Gonzalo de

; Lavandera, Iván

; Gotor-Fernández, Vicente

; Gotor, Vicente

Journal of the Brazilian Chemical Society

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jun 2014, Volume 25 N. 6 Pages 987 - 994

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

A síntese de derivados do tianfenicol, catalisada por lipases, foi investigada através da realização das reações de acilação e de hidrólise, como abordagens complementares, sendo a lipase Candida antarctica B o biocatalisador mais eficiente para as modificações seletivas de ambos, o tianfenicol e o correspondente diacetato do tianfenicol, respectivamente. Os melhores resultados foram obtidos nas reações de acilação com diferentes ésteres vinílicos, contendo cadeias carbônicas de comprimento variável, levando aos correspondentes 3'-monoésteres com excelentes rendimentos e em tempos reacionais curtos. As condições reacionais foram analisadas em termos de concentração de substrato, carga de enzima e tipo de doador de acila. Foi demonstrado o reuso da enzima por cinco vezes sem perda significativa de atividade. Alternativamente, a abordagem hidrolítica propiciou a preparação de alguns 1'-monoésteres em bons rendimentos, ainda que os níveis de reatividade e seletividade foram mais baixos que os obtidos na reação complementar de acetilação.

The lipase-catalyzed synthesis of thiamphenicol derivatives has been studied through complementary acylation and hydrolytic approaches, finding Candida antarctica lipase B as the most efficient biocatalyst for the selective modification of both thiamphenicol and thiamphenicol diacetate, respectively. The best results have been obtained using acylation reactions with different vinyl esters of variable length, yielding the corresponding 3'-monoesters with excellent yields and in short reaction times. The conditions have been analyzed in terms of substrate concentration, enzyme loading and type of acyl donor. The reuse of the enzyme for five-times without significant loss of the activity has also been demonstrated. Alternatively, the hydrolytic approach has allowed the preparation of some 1'-monoesters in good yields, although the reactivity and selectivity levels were lower than the ones achieved for the complementary acetylation reaction.

https://doi.org/10.5935/0103-5053.20140069 1162 downloads

10.

Isolation and antifungal susceptibility testing of Trichosporon asahii in Ceará, Brazil
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Menezes, Everardo Albuquerque

; Marinho, José Arlécio de Sousa

; Angelo, Maria Rozzelê F.

; Cunha, Maria da Conceição dos Santos Oliveira

; Cunha, Francisco Afrânio

; Vasconcelos Júnior, Antônio Alexandre de

Revista do Instituto de Medicina Tropical de São Paulo

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feb 2012, Volume 54 N. 1 Pages 1 - 3

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Trichosporon spp. são leveduras capazes de causar doença invasiva, que afetam principalmente pacientes imunocomprometidos. Uma cepa clínica de T. asahii foi isolada em hemocultura de paciente internado no Hospital Geral de Fortaleza. Os testes de suscetibilidade foram realizados por difusão em disco e microdiluição em caldo. A cepa isolada do T. asahii foi resistente ao fluconazol, o paciente fez uso de anfotericina B e caspofungina então a cura microbiológica ocorreu. Foi o primeiro isolamento e identificação de T. asahii em hemocultura no Ceará, Brasil.

Trichosporon spp. are yeasts capable of causing invasive disease, which mainly affect immunocompromised patients. A clinical strain of T. asahii was isolated from the blood cultures of patients admitted to the General Hospital of Fortaleza. Susceptibility tests were conducted by disk diffusion and broth microdilution. The isolated strain of T. asahii was resistant to fluconazole. The patient used amphotericin B and caspofungin in order to facilitate the microbiological cure. It was the first isolation and identification of T. asahii in blood culture in Ceará, Brazil.

3546 downloads Cited 1 time in SciELO

11.

Diterpene and other constituents from Stemodia maritima (Scrophulariaceae)
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Rodrigues, Francisco E. A.

; Lima, Jefferson Q.

; Oliveira, Maria da Conceição F. de

; Vasconcelos, Jackson N.

; Santiago, Gilvandete M. P.

; Mafezoli, Jair

; Braz-Filho, Raimundo

; Arriaga, Angela M. C.

Journal of the Brazilian Chemical Society

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2010, Volume 21 N. 8 Pages 1581 - 1586

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Um novo diterpeno, (5S*,8S*,9R*,10S*)-11β,12β-epoxi-9α-hidróxi-19(4→3) abeo-abieta-3,13-dieno-19,18-olideo, e as substâncias conhecidas estemodina, D-manitol, ácido betulínico, uma mistura de 3β-O-β-D-glicopiranosil-β-sitosterol e 3β-O-β-D-glicopiranosilestigmasterol, e 5,7,4'-triidróxi-3,8,3'-trimetoxiflavona, foram isolados das folhas e talos de Stemodia maritima. A elucidação estrutural de todas as substâncias baseou-se na interpretação de dados espectrais, principalmente RMN (1D e 2D) e espectrometria de massa (EM), envolvendo comparação com valores descritos na literatura.

A new diterpene, (5S*,8S*,9R*,10S*)-11β,12β-epoxy-9α-hydroxy-19(4→3) abeo-abieta-3,13-diene-19,18-olide, together with the known compounds stemodin, D-mannitol, betulinic acid, a mixture of 3β-O-β-D-glucopyranosyl-β-sitosterol and 3β-O-β-D-glucopyranosylstigmasterol and 5,7,4'-trihydroxy-3,8,3'-trimethoxyflavone were isolated from the leaves and stems of Stemodia maritima. Structural elucidation of all compounds was based on interpretation of spectral data, mainly NMR (1D and 2D) and MS, including comparison with values described in the literature.

2765 downloads

12.

Candida tropicalis CE017: a new Brazilian enzymatic source for the bioreduction of aromatic prochiral ketones
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Vieira, Gizelle A. B.

; Araujo, Daniel M. de Freitas

; Lemos, Telma L. G.

; Mattos, Marcos Carlos de

; Oliveira, Maria da Conceição F. de

; Melo, Vânia M. M.

; Gonzalo, Gonzalo de

; Gotor-Fernández, Vicente

; Gotor, Vicente

Journal of the Brazilian Chemical Society

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2010, Volume 21 N. 8 Pages 1509 - 1516

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

A reatividade e estereosseletividade apresentadas por uma nova cepa de Candida tropicalis na redução de cetonas pró-quirais foram comparadas com cepas de microrganismos, estudadas em nosso laboratório, provenientes da biodiversidade brasileira. Neste caso, Candida tropicalis demonstrou-se como um agente redutor versátil e estereosseletivo na biorredução de uma série de cetonas aromáticas. Estes compostos pró-quirais foram convertidos aos correspondentes álcoois opticamente ativos com moderada a excelente estereopreferência dependendo da estrutura do substrato. Entre as cetonas utilizadas, as nitroacetofenonas foram enzimaticamente reduzidas aos correspondentes (S)-álcoois enantiopuros com completa conversão.

The reactivity and stereoselectivity showed by a new strain of Candida tropicalis in the reduction of prochiral ketones have been compared with the ones previously attained in our laboratory using microorganisms from the Brazilian biodiversity. In this manner, Candida tropicalis has demonstrated its versatility as stereoselective agent in the bioreduction of a series of aromatic ketones. These prochiral compounds were converted into their corresponding optically alcohols with moderate to excellent stereopreference depending on the substrate structure. Among ketones tested, nitroacetophenones were enzymatically reduced to enantiopure (S)-alcohol with complete conversion.

4318 downloads

13.

Flavonoides e outras substâncias de Lippia sidoides e suas atividades antioxidantes
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Almeida, Macia Cleane S. de

; Alves, Leonardo A.

; Souza, Luciana Gregório da S.

; Machado, Luciana L.

; Matos, Marcos C. de

; Oliveira, Maria Conceição F. de

; Lemos, Telma L. G.

; Braz-Filho, Raimundo

Química Nova

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2010, Volume 33 N. 9 Pages 1877 - 1881

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

The chemical investigation of the ethanol extracts of stems, roots and leaves of Lippia sidoides led to the isolation of: steroid β-sitosterol, naphthoquinone tecomaquinone, monoterpene carvacrol, flavonoid 4',5,7-trihydroxyflavanone (naringenin), 3',4',5,7-tetrahydroxyflavanone and 4',5,7-trihydroxy-6-methoxyflavone flavonoids mixture, and 3,4,4',6'-tetrahydroxydihydrochalcone-2'-O-β-D-glucopyranoside and 4,4',6'-trihydroxydihydrochalcone-2'-O- β-D-glucopyranoside dihydrochalcones mixture. Their structures were characterized on the basis of spectral data, mainly ¹H and 13C NMR (1D and 2D) and mass spectra. The ethanol extract and isolated compounds were evaluated for their antioxidative properties using the method of inhibition of free radical DPPH (2,2-diphenyl-1-picrylhydrazyl).

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14.

Constituents and antioxidant activity of two varieties of coconut water (Cocos nucifera L.)
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Fonseca, Aluísio M. da

; Bizerra, Ayla M. C.

; Souza, João Sammy N. de

; Monte, Francisco José Q.

; Oliveira, Maria da Conceição F. de

; Mattos, Marcos C. de

; Cordell, Geoffrey A.

; Braz-Filho, Raimundo

; Lemos, Telma L. G.

Revista Brasileira de Farmacognosia

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mar 2009, Volume 19 N. 1b Pages 193 - 198

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Uma análise dos componentes da água-de-coco (Cocos nucifera L.) de duas variedades da fruta (verde e amarelo) por hidrodestilação e extração com solvente, mostrou a presença de álcoois, cetonas, tióis, ácidos carboxílicos, fenóis, e ésteres. Significativa atividade antioxidante foi observada, usando o método DPPH, para as amostras obtidas por hidrodestilação e extração de éter de petróleo para ambas as variedades do coco.

An analysis of the constituents of coconut (Cocos nucifera L.) water from two fruit varieties (green and yellow) by hydrodistillation and solvent extraction showed the presence of alcohols, ketones, thiols, carboxylic acids, phenols, and esters. Substantial antioxidant activity was observed, using the DPPH assay, for the samples obtained by hydrodistillation and petroleum ether extraction of both coconut varieties.

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15.

Alcaloides iboga de Peschiera affinis (Apocynaceae) - Atribuição inequívoca dos deslocamentos químicos dos átomos de hidrogênio e carbono: atividade antioxidante
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Santos, Allana Kellen L.

; Magalhães, Ticiane S.

; Monte, Francisco Jose Q.

; Mattos, Marcos Carlos de

; Oliveira, Maria Conceição F. de

; Almeida, Maria Mozarina B.

; Lemos, Telma L. G.

; Braz-Filho, Raimundo

Química Nova

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2009, Volume 32 N. 7 Pages 1834 - 1838

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Six known alkaloids iboga type and the triterpen α- and β-amyrin acetate were isolated from the roots and stems of Peschiera affinis. Their structures were characterized on the basis of spectral data mainly NMR and mass spectra. 1D and 2D NMR spectra were also used to unequivocal ¹H and 13C chemical shift assignments of alkaloids. The ethanolic extract of roots, alkaloidic and no-alkaloidic fractions and iso-voacristine hydroxyindolenine and voacangine were evaluated for their antioxidative properties using an autographic assay based on β-carotene bleaching on TLC plates, and also spectrophotometric detection by reduction of the stable DPPH (2,2-diphenyl-1-picrylhydrazyl) free radical.

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