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Resumo Fundamento As complicações cardiovasculares da COVID-19 são aspectos importantes da patogênese e do prognóstico da doença. Evidências do papel prognóstico da troponina e da lesão miocárdica em pacientes hospitalizados com COVID-19 na América Latina são ainda escassos. Objetivos Avaliar a lesão miocárdica como preditor independente de mortalidade hospitalar e suporte ventilatório mecânico em pacientes hospitalizados, do registro brasileiro de COVID-19. Métodos Este estudo coorte é um subestudo do registro brasileiro de COVID-19, conduzido em 31 hospitais brasileiros de 17 cidades, de março a setembro de 2020. Os desfechos primários incluíram mortalidade hospitalar e suporte ventilatório mecânico invasivo. Os modelos para os desfechos primários foram estimados por regressão de Poisson com variância robusta, com significância estatística de p<0,05. Resultados Dos 2925 pacientes [idade mediana de 60 anos (48-71), 57,1%], 27,3% apresentaram lesão miocárdica. A proporção de pacientes com comorbidades foi maior nos pacientes com lesão miocárdica [mediana 2 (1-2) vs. 1 (0-20)]. Os pacientes com lesão miocárdica apresentaram maiores valores medianos de peptídeo natriurético cerebral, lactato desidrogenase, creatina fosfoquinase, N-terminal do pró-peptídeo natriurético tipo B e proteína C reativa em comparação a pacientes sem lesão miocárdica. Como fatores independentes, proteína C reativa e contagem de plaquetas foram relacionados com o risco de morte, e neutrófilos e contagem de plaquetas foram relacionados ao risco de suporte ventilatório mecânico invasivo. Os pacientes com níveis elevados de troponina apresentaram um maior risco de morte (RR 2,03, IC95% 1,60-2,58) e suporte ventilatório mecânico (RR 1,87;IC95% 1,57-2,23), em comparação àqueles com níveis de troponina normais. Conclusão Lesão cardíaca foi um preditor independente de mortalidade hospitalar e necessidade de suporte ventilatório mecânico em pacientes hospitalizados com COVID-19. COVID19 COVID 19 COVID-1 doença escassos COVID19. 19. COVID19, 19, 3 cidades 2020 invasivo robusta p005 p 0 05 p<0,05 292 idade 6 4871, 4871 48 71 , (48-71) 57,1%, 571 57,1% 57 57,1%] 273 27 27,3 12 (1-2 vs 020. 020 20 . (0-20)] cerebral desidrogenase fosfoquinase Nterminal N terminal própeptídeo pró independentes RR 203 03 2,03 IC95 IC 1,602,58 160258 1,60 2,58 58 1,60-2,58 1,87IC95% 187IC95 1,87 87 1,87;IC95 1,572,23, 157223 1,57 2,23 23 1,57-2,23) normais COVID1 COVID- 202 p00 p<0,0 29 487 4 7 (48-71 57,1 5 27, (1- 02 (0-20) 2,0 IC9 602 1,602,5 16025 160 1,6 258 2,5 1,60-2,5 87IC95 1,87IC95 187IC9 187 1,8 8 1,87;IC9 572 1,572,23 15722 157 1,5 223 2,2 1,57-2,23 p0 p<0, (48-7 57, (1 (0-20 2, 1,602, 1602 16 1, 25 1,60-2, 87IC9 1,87IC9 187IC 18 1,87;IC 1,572,2 1572 15 22 1,57-2,2 p<0 (48- ( (0-2 1,602 1,60-2 87IC 1,87IC 1,572, 1,57-2, p< (48 (0- 1,60- 1,572 1,57-2 (4 (0 1,57-

Abstract Background Cardiovascular complications of COVID-19 are important aspects of the disease’s pathogenesis and prognosis. Evidence on the prognostic role of troponin and myocardial injury in Latin American hospitalized COVID-19 patients is still scarce. Objectives To evaluate myocardial injury as independent predictor of in-hospital mortality and invasive mechanical ventilation support in hospitalized patients, from the Brazilian COVID-19 Registry. Methods This cohort study is a substudy of the Brazilian COVID-19 Registry, conducted in 31 Brazilian hospitals of 17 cities, March-September 2020. Primary outcomes included in-hospital mortality and invasive mechanical ventilation support. Models for the primary outcomes were estimated by Poisson regression with robust variance, with statistical significance of p<0.05. Results Of 2,925 patients (median age of 60 years [48-71], 57.1% men), 27.3% presented myocardial injury. The proportion of patients with comorbidities was higher among patients with cardiac injury (median 2 [1-2] vs. 1 [0-2]). Patients with myocardial injury had higher median levels of brain natriuretic peptide, lactate dehydrogenase, creatine phosphokinase, N-terminal pro-brain natriuretic peptide, and C-reactive protein than patients without myocardial injury. As independent predictors, C-reactive protein and platelet counts were related to the risk of death, and neutrophils and platelet counts were related to the risk of invasive mechanical ventilation support. Patients with high troponin levels presented a higher risk of death (RR 2.03, 95% CI 1.60-2.58) and invasive mechanical ventilation support (RR 1.87, 95% CI 1.57-2.23), when compared to those with normal troponin levels. Conclusion Cardiac injury was an independent predictor of in-hospital mortality and the need for invasive mechanical ventilation support in hospitalized COVID-19 patients. COVID19 COVID 19 COVID-1 diseases disease s prognosis scarce inhospital hospital Registry 3 cities MarchSeptember March September 2020 variance p005 p 0 05 p<0.05 2925 925 2,92 6 4871, 4871 48 71 , [48-71] 571 57 57.1 men, men men) 273 27 27.3 12 [1-2 vs 02. 02 . [0-2]) peptide dehydrogenase phosphokinase Nterminal N terminal probrain pro Creactive C reactive predictors RR 203 03 2.03 95 1.602.58 160258 1.60 2.58 58 1.60-2.58 187 87 1.87 1.572.23, 157223 1.57 2.23 23 1.57-2.23) COVID1 COVID- 202 p00 p<0.0 292 92 2,9 487 4 7 [48-71 5 57. 27. [1- [0-2] 20 2.0 9 602 1.602.5 16025 160 1.6 258 2.5 1.60-2.5 18 8 1.8 572 1.572.23 15722 157 1.5 223 2.2 1.57-2.23 p0 p<0. 29 2, [48-7 [1 [0-2 2. 1.602. 1602 16 1. 25 1.60-2. 1.572.2 1572 15 22 1.57-2.2 p<0 [48- [ [0- 1.602 1.60-2 1.572. 1.57-2. p< [48 [0 1.60- 1.572 1.57-2 [4 1.57-

https://doi.org/10.36660/abc.20220151

Retratados e ainda citados: perfil de citações pós-retratação em artigos de pesquisadores brasileiros citados pósretratação pós retratação
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Santos-d’Amorim, Karen

; Melo, Rinaldo Ribeiro de

; Correia, Anna Elizabeth Galvão Coutinho

; Miranda, Májory K. Fernandes de Oliveira

; Silveira, Murilo Artur Araújo da

Em Questão

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2023, Volume 29 elocation e-125494

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo: Caracteriza os artigos retratados mais citados autorados por pesquisadores brasileiros, tipifica as citações pós-retratação e identifica padrões e outliers associados aos documentos citados e citantes analisados. Utiliza o método bibliométrico e a técnica de análise de citações, configurando-se como uma pesquisa exploratória. Dos resultados obtidos a partir da análise de 512 citações distribuídas em 407 documentos citantes, identificou-se que 75,8% consistiam em citações neutras, 23% em citações positivas e 1,2% em menções negativas. A prevalência das citações neutras mostra que estes artigos continuam sendo citados como documentos presentes na literatura, sem o julgamento de sua validade científica, o que também levanta preocupações sobre as práticas de citação na Academia. Resumo brasileiros pósretratação pós retratação analisados configurandose configurando se exploratória 51 40 identificouse identificou 758 75 8 75,8 23 12 1 2 1,2 negativas literatura científica Academia 5 4 7 75, 1,

Abstract: It characterizes the most cited retracted articles authored by Brazilian researchers, typifies post-retraction citations, and identifies patterns and outliers associated with the cited and citing documents analyzed. It uses the bibliometric method and the technique of citation analysis, configuring itself as exploratory research. From the results obtained from the analysis of 512 citations distributed in 407 citing documents, it was identified that 75.8% consisted of neutral citations 23.0% of positive citations and 1.2% of negative mentions. The prevalence of neutral citations shows that these articles continue to be cited as documents present in the literature without judging their scientific validity. Abstract researchers postretraction post retraction analyzed research 51 40 758 75 8 75.8 230 23 0 23.0 12 1 2 1.2 mentions validity 5 4 7 75. 23. 1.

https://doi.org/10.19132/1808-5245.29.125494

Dados de Vida Real sobre o Uso da Hidroxicloroquina ou da Cloroquina Combinadas ou Não à Azitromicina em Pacientes com Covid-19: Uma Análise Retrospectiva no Brasil Covid19 Covid 19 Covid-19 Covid1 1 Covid-1 Covid-
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Souza-Silva, Maíra Viana Rego

; Pereira, Daniella Nunes

; Pires, Magda Carvalho

; Vasconcelos, Isabela Muzzi

; Schwarzbold, Alexandre Vargas

; Vasconcelos, Diego Henrique de

; Pereira, Elayne Crestani

; Manenti, Euler Roberto Fernandes

; Costa, Felício Roberto

; Aguiar, Filipe Carrilho de

; Anschau, Fernando

; Bartolazzi, Frederico

; Nascimento, Guilherme Fagundes

; Vianna, Heloisa Reniers

; Batista, Joanna d’Arc Lyra

; Machado-Rugolo, Juliana

; Ruschel, Karen Brasil

; Ferreira, Maria Angélica Pires

; Oliveira, Leonardo Seixas de

; Menezes, Luanna Silva Monteiro

; Ziegelmann, Patricia Klarmann

; Tofani, Marcela Gonçalves Trindade

; Bicalho, Maria Aparecida Camargos

; Nogueira, Matheus Carvalho Alves

; Guimarães-Júnior, Milton Henriques

; Aguiar, Rúbia Laura Oliveira

; Rios, Danyelle Romana Alves

; Polanczyk, Carisi Anne

; Marcolino, Milena Soriano

Arquivos Brasileiros de Cardiologia

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2023, Volume 120 N. 9 elocation e20220935

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Fundamento Apesar da ausência de evidência mostrando benefícios da hidroxicloroquina e da cloroquina combinadas ou não à azitromicina no tratamento da covid-19, esses medicamentos têm sido amplamente prescritos no Brasil. Objetivos Avaliar desfechos, incluindo moralidade hospitalar, alterações eletrocardiográficas, tempo de internação, admissão na unidade de terapia intensiva, e necessidade de diálise e de ventilação mecânica em pacientes hospitalizados com covid-19 que receberam cloroquina ou hidroxicloroquina, e comparar os desfechos entre aqueles pacientes e seus controles pareados. Métodos Estudo multicêntrico retrospectivo do tipo coorte que incluiu pacientes com diagnóstico laboratorial de covid-19 de 37 hospitais no Brasil de março a setembro de 2020. Escore de propensão foi usado para selecionar controles pareados quanto a idade, sexo, comorbidades cardiovasculares, e uso de corticosteroides durante a internação. Um valor de p<0,05 foi considerado estatisticamente significativo. Resultados Dos 7850 pacientes com covid-19, 673 (8,6%) receberam hidroxicloroquina e 67 (0,9%) cloroquina. A idade mediana no grupo de estudo foi 60 (46-71) anos e 59,1% eram mulheres. Durante a internação, 3,2% dos pacientes apresentaram efeitos adversos e 2,2% necessitaram de interromper o tratamento. Alterações eletrocardiográficas foram mais prevalentes no grupo hidroxicloroquina/cloroquina (13,2% vs. 8,2%, p=0,01), e o prolongamento do intervalo QT corrigido foi a principal diferença (3,6% vs. 0,4%, p<0,001). O tempo mediano de internação hospitalar foi maior no grupo usando CQ/HCQ em relação aos controles (9,0 [5,0-18,0] vs. 8,0 [4,0-14,0] dias). Não houve diferenças estatisticamente significativas entre os grupos quanto a admissão na unidade de terapia intensiva (35,1% vs. 32,0%; p=0,282), ventilação mecânica invasiva (27,0% vs. 22,3%; p=0,074) ou mortalidade (18,9% vs. 18,0%; p=0,682). Conclusão Pacientes com covid-19 tratados com cloroquina ou hidroxicloroquina apresentaram maior tempo de internação hospitalar, em comparação aos controles. Não houve diferença em relação a admissão em unidade de terapia intensiva, necessidade de ventilação mecânica e mortalidade hospitalar. covid19, covid19 covid 19, 19 covid-1 3 2020 sexo cardiovasculares p005 p 0 05 p<0,0 significativo 785 8,6% 86 8 6 (8,6% 0,9% 09 9 (0,9% 4671 46 71 (46-71 591 59 1 59,1 mulheres 32 2 3,2 22 2,2 hidroxicloroquinacloroquina 13,2% 132 13 (13,2 vs 82 8,2% p=0,01, p001 p=0,01 , 01 p=0,01) 3,6% 36 (3,6 04 4 0,4% p<0,001. p0001 p<0,001 . 001 p<0,001) CQHCQ CQ HCQ 9,0 90 (9, 5,018,0 50180 5,0 18,0 5 18 [5,0-18,0 80 8, 4,014,0 40140 4,0 14,0 14 [4,0-14,0 dias. dias dias) 35,1% 351 35 (35,1 32,0% 320 p=0,282, p0282 p=0,282 282 p=0,282) 27,0% 270 27 (27,0 22,3% 223 p=0,074 p0074 074 18,9% 189 (18,9 18,0% 180 p=0,682. p0682 p=0,682 682 p=0,682) covid1 covid- 202 p00 p<0, 78 8,6 (8,6 0,9 (0,9 467 7 (46-7 59, 3, 2, 13,2 (13, 8,2 p=0,0 3,6 (3, 0,4 p000 p<0,00 00 9, (9 018 5,018, 5018 50 5, 18, [5,0-18, 014 4,014, 4014 40 4, 140 14, [4,0-14, 35,1 (35, 32,0 p028 p=0,28 28 27,0 (27, 22,3 p=0,07 p007 07 18,9 (18, p068 p=0,68 68 20 p0 p<0 (8, 0, (0, (46- 13, (13 p=0, (3 ( 5,018 501 [5,0-18 4,014 401 [4,0-14 35, (35 32, p02 p=0,2 27, (27 22, (18 p06 p=0,6 p< (8 (0 (46 (1 p=0 5,01 [5,0-1 4,01 [4,0-1 (2 (4 p= [5,0- [4,0- [5,0 [4,0 [5, [4, [5 [4 [

Abstract Background Despite no evidence showing benefits of hydroxychloroquine and chloroquine with or without azithromycin for COVID-19 treatment, these medications have been largely prescribed in Brazil. Objectives To assess outcomes, including in-hospital mortality, electrocardiographic abnormalities, hospital length-of-stay, admission to the intensive care unit, and need for dialysis and mechanical ventilation, in hospitalized COVID-19 patients who received chloroquine or hydroxychloroquine, and to compare outcomes between those patients and their matched controls. Methods A retrospective multicenter cohort study that included consecutive laboratory-confirmed COVID-19 patients from 37 Brazilian hospitals from March to September 2020. Propensity score was used to select matching controls by age, sex, cardiovascular comorbidities, and in-hospital use of corticosteroid. A p-value <0.05 was considered statistically significant. Results From 7,850 COVID-19 patients, 673 (8.6%) received hydroxychloroquine and 67 (0.9%) chloroquine. The median age in the study group was 60 years (46 - 71) and 59.1% were women. During hospitalization, 3.2% of patients presented side effects and 2.2% required therapy discontinuation. Electrocardiographic abnormalities were more prevalent in the chloroquine/hydroxychloroquine group (13.2% vs. 8.2%, p=0.01), and the long corrected QT interval was the main difference (3.6% vs. 0.4%, p<0.001). The median hospital length of stay was longer in the HCQ/CQ + AZT group than in controls (9.0 [5.0, 18.0] vs. 8.0 [4.0, 14.0] days). There was no statistical differences between groups in intensive care unit admission (35.1% vs. 32.0%; p=0.282), invasive mechanical ventilation support (27.0% vs. 22.3%; p=0.074) or mortality (18.9% vs. 18.0%; p=0.682). Conclusion COVID-19 patients treated with chloroquine or hydroxychloroquine had a longer hospital length of stay, when compared to matched controls. Intensive care unit admission, invasive mechanical ventilation, dialysis and in-hospital mortality were similar. COVID19 COVID 19 COVID-1 treatment Brazil inhospital lengthofstay, lengthofstay length-of-stay laboratoryconfirmed laboratory confirmed 3 2020 sex comorbidities corticosteroid pvalue p value 005 0 05 <0.0 significant 7850 7 850 7,85 8.6% 86 8 6 (8.6% 0.9% 09 9 (0.9% 46 (4 71 591 59 1 59.1 women hospitalization 32 2 3.2 22 2.2 discontinuation chloroquinehydroxychloroquine 13.2% 132 13 (13.2 vs 82 8.2% p=0.01, p001 p=0.01 , 01 p=0.01) 3.6% 36 (3.6 04 4 0.4% p<0.001. p0001 p<0.001 . 001 p<0.001) HCQCQ HCQ CQ 9.0 90 (9. 5.0, 50 5 [5.0 18.0 180 18 80 8. 4.0, 40 [4.0 14.0 140 14 days. days days) 35.1% 351 35 (35.1 32.0% 320 p=0.282, p0282 p=0.282 282 p=0.282) 27.0% 270 27 (27.0 22.3% 223 p=0.074 p0074 074 18.9% 189 (18.9 18.0% p=0.682. p0682 p=0.682 682 p=0.682) similar COVID1 COVID- 202 00 <0. 785 85 7,8 8.6 (8.6 0.9 (0.9 ( 59. 3. 2. 13.2 (13. 8.2 p00 p=0.0 3.6 (3. 0.4 p000 p<0.00 9. (9 5.0 [5. 18. 4.0 [4. 14. 35.1 (35. 32.0 p028 p=0.28 28 27.0 (27. 22.3 p=0.07 p007 07 18.9 (18. p068 p=0.68 68 20 <0 78 7, (8. 0. (0. 13. (13 p0 p=0. (3 p<0.0 5. [5 4. [4 35. (35 32. p02 p=0.2 27. (27 22. (18 p06 p=0.6 < (8 (0 (1 p=0 p<0. [ (2 p= p<0 p<

https://doi.org/10.36660/abc.20220935

Health education: a booklet for colostomized people in use of the plug
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Diniz, Iraktânia Vitorino

; Mendonça, Ana Elza Oliveira de

; Brito, Karen Krystine Gonçalves de

; Albuquerque, Adriana Montenegro de

; Oliveira, Simone Helena dos Santos

; Costa, Isabelle Katherinne Fernandes

; Soares, Maria Júlia Guimarães Oliveira

Revista Brasileira de Enfermagem

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2022, Volume 75 N. 1 elocation e20210102

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

RESUMO Objetivo: Construir e validar cartilha sobre o uso do oclusor da colostomia como suporte tecnológico para intervenção educative Métodos: Estudo metodológico com foco na produção de tecnologia leve-dura para pessoas colostomizadas em uso de oclusor, desenvolvido em três etapas: revisão da literatura; validação com 13 experts; e com 7 pessoas colostomizadas. Resultados: O conteúdo que compôs a cartilha foi selecionado com base na análise dos artigos identificados na Etapa 1. Na Etapa 2, quanto ao conteúdo, o número de páginas e a aparência obtiveram Índice de Validade de Conteúdo 0,85 e 1,00 respectivamente. Na Etapa 3, o Índice de Validade de Conteúdo mínimo foi de 0,71 em dois itens referentes à organização e 0,86 no estilo da escrita. Os demais itens obtiveram Índice de Validade de Conteúdo 1,0. Conclusão: Validou-se a cartilha com experts e pessoas colostomizadas, e a versão final, contendo 50 páginas, foi ofertada aos profissionais da área de saúde e pessoas colostomizadas em uso do oclusor.

ABSTRACT Objective: To develop and validate a booklet on the use of the colostomy plug as a technological support for educational intervention. Methods: Methodological study focusing on the production of soft and hard technologies for colostomized people using a plug, developed in three stages: literature review; validation with 13 experts; and with seven colostomized persons. Results: The content for the booklet was selected based on the analysis of the articles identified in Step 1. In Step 2, regarding the content, the number of pages and appearance obtained a Content Validity Index of 0.85 and 1.00 respectively. In Step 3, the minimum Content Validity Index was 0.71 in two items related to organization and 0.86 for the writing style. The other items obtained a Content Validity Index of 1.0. Conclusion: The booklet was validated among experts and colostomized persons, and the final version, containing 50 pages, was offered to health professionals and colostomized people in use of a plug.

RESUMEN Objetivo: Construir y validar cartilla de uso del obturador de colostomía como suporte tecnológico para intervención educativa. Métodos: Estudio metodológico basado en producción de tecnología leve-dura para personas colostomizadas en uso de obturador, desarrollado en tres etapas: revisión de la literatura; validación con 13 expertos; y 7 personas colostomizadas. Resultados: Contenido que compuso la cartilla fue seleccionado basado en análisis de artículos identificados en la Etapa 1. En la Etapa 2, cuanto al contenido, el número de páginas y la apariencia obtuvieron Índice de Validez de Contenido 0,85 y 1,00 respectivamente. En la Etapa 3, el Índice de Validez de Contenido mínimo fue de 0,71 en dos ítems referentes a la organización y 0,86 en el estilo de la escrita. Los demás ítems obtuvieron Índice de Validez de Contenido 1,0. Conclusión: Validó la cartilla con expertos y personas colostomizadas, y la versión final, conteniendo 50 páginas, ofertada a los profesionales de la área de salud y personas colostomizadas en uso del obturador.

https://doi.org/10.1590/0034-7167-2021-0102 320 downloads

Evaluation of ApaI and FokI polymorphism of VDR gene and functional characterization in patients with fibromyalgia
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Santos, Stheace Kelly Fernandes Szezerbaty

; Fernandes, Karen Barros Parron

; Zicarelli, Carlos Alexandre Martins

; Santana, André Vinicius

; Perrucini, Priscila Daniele de Oliveira

; Poli-Frederico, Regina Célia

Fisioterapia em Movimento

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2022, Volume 35 elocation e35122

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Introdução: A fibromialgia (FM) é uma síndrome de origem desconhecida caracterizada por diversos sintomas, e embora sua patogênese não tenha sido completamente elucidada, parece estar relacionada às vias inflamatórias e alterações neuroquímicas no cérebro. Objetivo: Avaliar a associação entre os polimorfismos BsmI, ApaI e FokI do gene do receptor da vitamina D (VDR), seus polimorfismos e variáveis clínicas em mulheres com e sem FM. Métodos: Trata-se de um estudo caso-controle composto por um grupo de 53 mulheres com FM e outro com 40 mulheres sem a doença. Foram aplicados o Questionário de Dor de McGill, Questionário de Impacto da Fibromialgia, Escala Visual Analógica da Dor e o teste de sentar. A PCR em tempo real foi realizada para analisar o polimorfismo ApaI e FokI. Resultados: Houve associação estatística entre raça, comorbidade e FM, onde 78,4% dos indivíduos eram brancos e apresentavam FM (p < 0,002) e 96,1% tinham alguma comorbidade (p < 0,001). Setenta e seis vírgula cinco por cento (76,5%) dos pacientes com FM tiveram desempenho inferior no teste de abdominais (p < 0,001). Também houve associação entre as frequências genotípicas e alélicas dos polimorfismos Apal e FokI do gene VDR e FM (p < 0,001). No polimorfismo ApaI do gene VDR, o genótipo CC apresentou maior frequência em mulheres com FM, o alelo C para o polimorfismo Apal foi 3,33 vezes mais provável, e o polimorfismo FokI teve 10,9 vezes mais chance de desenvolver FM (p < 0,0001). Conclusão: Mulheres com alelo C para polimorfismo ApaI têm 3,33 vezes mais chance de ter FM (IC 95% = 1,58-7,02; p = 0,0024), e no polimorfismo FokI, a prevalência do alelo T é 10,9 vezes maior (IC 95% = 4,76-25,38; p < 0,0001). Não foram encontradas associações significativas em relação ao polimorfismo BsmI e alelos de frequência (p = 0,062 e p = 0,078, respectivamente).

Abstract Introduction: Fibromyalgia (FM) is a syndrome of unknown origin characterized by several symptoms, and although its pathogenesis has not been completely elucidated, it seems to be related to inflammatory path-ways and neurochemical changes in the brain. Objective: To evaluate the association between BsmI, ApaI and FokI polymorphisms of the vitamin D receptor (VDR) gene, their polymorphisms, and clinical variables in women with and without FM. Methods: This is a case-control study composed of a group of 53 women with FM and another with 40 women without the disease. The McGill Pain Questionnaire, Fibromyalgia Impact Questionnaire, Pain Visual Analogue Scale and the sit-up test were applied. Real-time PCR was performed to analyze the ApaI and FokI polymorphism. Results: There was a statistical association between race, comorbidity and FM, where 78.4% of the individuals were white and had FM (p < 0.002) and 96.1% had some comorbidity (p < 0.001). Seventy-six point five percent (76.5%) of patients with FM underperformed in the sit-up test (p < 0.001). There was also an association between the genotypic and allele frequencies of the VDR and FM gene Apal and FokI polymorphisms (p < 0.001). In the VDR gene ApaI polymorphism, the CC genotype exhibited a higher frequency in women with FM, the C allele for the Apal polymorphism was 3.33 times more likely, and the FokI polymorphism was 10.9 times more likely to develop FM (p < 0,0001). Conclusion: Women with C allele for ApaI polymorphism are 3.33 times more likely to have FM (95%CI = 1.58-7.02; p = 0.0024), and in FokI polymorphism, the prevalence of T allele is 10.9 times greater (95% CI = 4.76-25.38; p < 0.0001). No significant associations were found in relation to BsmI polymorphism and frequency alleles (p = 0.062 and p = 0.078, respectively).

https://doi.org/10.1590/fm.2022.35122

Reasons and implications of retracted articles in Brazil
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SANTOS-D’AMORIM, Karen

; CORREIA, Anna Elizabeth Galvão Coutinho

; MIRANDA, Májory Karoline Fernandes de Oliveira

; SANTA-CRUZ, Petrus

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2021, Volume 33 elocation e210001

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Ao longo dos anos, retratações decorrentes de erros não-intencionais ou de má conduta na pesquisa científica têm sido objeto de discussão, sendo indispensáveis para evitar a propagação de informações errôneas. Para compreender como se configuram os artigos retratados no cenário brasileiro, este estudo caracteriza as retratações de autoria ou coautoria de pesquisadores brasileiros entre 2002 e 2019 relacionando-as às consequências e impactos na atividade científica. A partir de levantamento feito na base Retraction Watch, foram analisados aspectos quantitativos sobre as razões das retratações, estratificação por áreas do conhecimento, tempo entre publicação e retratação, associação entre periódicos e fator de impacto, reincidência de pesquisadores, colaboração institucional entre instituições brasileiras e outros países e fontes de financiamento. Dos resultados obtidos a partir da análise das 162 retratações, nota-se a prevalência de plágio (12,2%), de retratações de artigos na área de Biociências (28,1%), incidência de periódicos com Fator de Impacto entre 2 e 5 (38,0%) e de equipes de autoria compostas por dois a quatro autores (38,8%). As ocorrências e reincidências de retratações por má conduta trazem impactos na atividade profissional do autor e para a ciência. Assim, ressalta-se a importância da rápida retratação, mas também da necessidade de se aprimorar mecanismos para evitar que esses artigos sejam, desde o início, publicados.

Abstract Over the years, cases of retractions due to unintentional errors or research misconduct have been the subject of discussion, being indispensable to avoid the propagation of misleading information. To understand this matter in the Brazilian scenario, this study characterizes the retractions of authorship or co-authorship of Brazilian researchers between 2002 and 2019, their related consequences and impacts on scientific activity. With a data collection performed at the Retraction Watch database, we analyzed quantitative aspects of the reasons for retractions, stratification by areas of knowledge, the time between publication and retraction, the association of journals and impact factor, authors’ recidivism, the institutional collaboration between Brazilian institutions and countries and funding sources. The results of the analysis of 162 retractions indicate the prevalence of plagiarism (12.2%), the incidence of retracted articles in the Bioscience area (28.1%), in journals with Impact Factors between 2 and 5 (38.0%), and with 2 to 4 authors (38.8%). The occurrences and recurrences of retractions due to misconduct have an impact not only the author’s professional activity but science. Thus, this article emphasizes the importance of prompt retraction, as well as of the need to improve mechanisms to prevent these articles from being published from the start.

https://doi.org/10.1590/2318-0889202133e210001 50 downloads

Maintenance of venomous snakes in captivity for venom production at Butantan Institute from 1908 to the present: a scoping history
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Grego, Kathleen Fernandes

; Vieira, Samira Emanuela Maria

; Vidueiros, Jarbas Prado

; Serapicos, Eliana de Oliveira

; Barbarini, Cibele Cíntia

; Silveira, Giovanni Perez Machado da

; Rodrigues, Fabíola de Souza

; Alves, Lucas de Carvalho Francisco

; Stuginski, Daniel Rodrigues

; Rameh-de-Albuquerque, Luciana Carla

; Furtado, Maria de Fátima Domingues

; Tanaka-Azevedo, Anita Mitico

; Morais-Zani, Karen de

; Rocha, Marisa Maria Teixeira da

; Fernandes, Wilson

; Sant’Anna, Sávio Stefanini

Journal of Venomous Animals and Toxins including Tropical Diseases

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2021, Volume 27 elocation e20200068

Abstract: En | Text: En | PDF: En

Abstract Maintenance of snakes at Butantan Institute started in the last century, intending to produce a different antivenom serum to reduce death caused by snakebites. Through a successful campaign coordinated by Vital Brazil, farmers sent venomous snakes to Butantan Institute by the railway lines with no cost. From 1908 to 1962, the snakes were kept in an outdoor serpentarium, where venom extraction was performed every 15 days. During this period, the snake average survival was 15 days. In 1963, the snakes were transferred to an adapted building, currently called Laboratory of Herpetology (LH), to be maintained in an intensive system. Although the periodicity of venom extraction remained the same, animal average survival increased to two months. With the severe serum crisis in 1983, the Ministry of Health financed remodeling for the three public antivenom producers, and with this support, the LH could be improved. Air conditioning and exhausting systems were installed in the rooms, besides the settlement of critical hygienic-sanitary managements to increase the welfare of snakes. In the early 1990s, snake survival was ten months. Over the years to the present day, several improvements have been made in the intensive serpentarium, as the establishment of two quarantines, feeding with thawed rodents, an interval of two months between venom extraction routines, and monitoring of snake health through laboratory tests. With these new protocols, average snake survival increased significantly, being eight years for the genus Bothrops, ten years for genus Crotalus and Lachesis, and four years for the genus Micrurus. Aiming the production of venoms of good quality, respect for good management practices is essential for the maintenance of snakes in captivity. New techniques and efficient management must always be sought to improve animal welfare, the quality of the venom produced, and the safety of those working directly with the venomous snakes.

https://doi.org/10.1590/1678-9199-jvatitd-2020-0068 1418 downloads

Peripheral venous access using devices over needles with and without extension: costs and outcomes
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Lima, Antônio Fernandes Costa

; Saba, Amanda

; Neves Filho, Abílio Gonçalves das

; Couto, Karen Aparecida

; Silva, Luciana Oliveira e

Revista Brasileira de Enfermagem

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2020, Volume 73 N. 5 elocation e20180921

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

RESUMO Objetivos: analisar o custo direto médio e os desfechos de permanência de acesso venoso periférico, utilizando dispositivos sobre agulha com e sem extensão. Métodos: pesquisa quantitativa, exploratório-descritiva. Acompanharam-se as punções venosas e o tempo de permanência dos dispositivos. Calculou-se o custo direto médio multiplicando-se o tempo (cronometrado) despendido por profissionais de enfermagem pelo custo unitário da mão de obra, somando-se ao custo dos materiais. Resultados: o custo direto médio total do uso de dispositivo “com extensão” (US$ 9,37) foi 2,9 vezes do que o custo do uso de dispositivo “sem extensão” (US$ 4,50), destacando-se os custos dos materiais, US$ 7,71 e US$ 2,66, respectivamente. Totalizando 96 horas de permanência, o “dispositivo sobre agulha com extensão” apresentou menor ocorrência de perda acidental. Conclusões: o uso do “dispositivo sobre agulha com extensão”, apesar do maior custo direto médio, foi mais eficaz para favorecer o adequado tempo de permanência do acesso venoso periférico.

ABSTRACT Objectives: to analyze the mean direct cost and peripheral venous access length outcomes using devices over needle with and without extension. Methods: quantitative, exploratory-descriptive research. Venous punctures and length of the devices were followed. The mean direct cost was calculated by multiplying the time (timed) spent by nursing professionals by the unit cost of labor, adding to the cost of materials. Results: the total mean direct cost of using devices “with extension” (US$ 9.37) was 2.9 times the cost of using devices “without extension” (US$ 4.50), US$ 7.71 and US$ 2.66, respectively. Totaling 96 hours of stay, the “device over needle with extension” showed a lower occurrence of accidental loss. Conclusions: the use of the “device over needle with extension”, despite its higher mean direct cost, was more effective in favoring adequate length of peripheral venous access.

RESUMEN Objetivos: analizar el costo directo promedio y los resultados de permanencia del acceso venoso periférico, utilizando dispositivos de aguja con y sin extensión. Métodos: investigación cuantitativa, exploratoria descriptiva. Se siguieron los pinchazos venosos y el tiempo de permanencia de los dispositivos. El costo directo promedio se calculó multiplicando el tiempo (cronometrado) dedicado por los profesionales de enfermería por el costo unitario de la mano de obra, lo que se suma al costo de los materiales. Resultados: el costo directo promedio total de usar dispositivos “extendidos” (US$ 9,37) fue 2,9 veces el costo de usar dispositivos “no extendidos” (US$ 4,50) de materiales, US$ 7.71 y US$ 2.66, respectivamente. Con un total de 96 horas de estadía, el “dispositivo de aguja extendida” mostró una menor ocurrencia de pérdida accidental. Conclusiones: a pesar del costo directo promedio más alto, el uso de un “dispositivo de aguja extendida” fue más efectivo para favorecer un tiempo de acceso venoso periférico adecuado.

https://doi.org/10.1590/0034-7167-2018-0921 1299 downloads

Peripheral venous access using devices over needles with and without extension: costs and outcomes
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Lima, Antônio Fernandes Costa

; Saba, Amanda

; Neves Filho, Abílio Gonçalves das

; Couto, Karen Aparecida

; Silva, Luciana Oliveira e

Revista Brasileira de Enfermagem

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2020, Volume 73 N. 5 elocation e20180921

Abstract: En Es Pt | Text: En Es Pt | PDF: En | PDF: Es | PDF: Pt

https://doi.org/10.1590/0034-7167-2018-0921 22 downloads

10.

Venom complexity of Bothrops atrox (common lancehead) siblings
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Hatakeyama, Daniela Miki

; Tasima, Lídia Jorge

; Bravo-Tobar, Cesar Adolfo

; Serino-Silva, Caroline

; Tashima, Alexandre Keiji

; Rodrigues, Caroline Fabri Bittencourt

; Aguiar, Weslei da Silva

; Galizio, Nathália da Costa

; Lima, Eduardo Oliveira Venancio de

; Kavazoi, Victor Koiti

; Gutierrez-Marín, Juan David

; Farias, Iasmim Baptista de

; Sant’Anna, Sávio Stefanini

; Grego, Kathleen Fernandes

; Morais-Zani, Karen de

; Tanaka-Azevedo, Anita Mitico

Journal of Venomous Animals and Toxins including Tropical Diseases

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2020, Volume 26 elocation e20200018

Abstract: En | Text: En | PDF: En

Abstract Background: Variability in snake venoms is a well-studied phenomenon. However, sex-based variation of Bothrops atrox snake venom using siblings is poorly investigated. Bothrops atrox is responsible for the majority of snakebite accidents in the Brazilian Amazon region. Differences in the venom composition of Bothrops genus have been linked to several factors such as ontogeny, geographical distribution, prey preferences and sex. Thus, in the current study, venom samples of Bothrops atrox male and female siblings were analyzed in order to compare their biochemical and biological characteristics. Methods: Venoms were collected from five females and four males born from a snake captured from the wild in São Bento (Maranhão, Brazil), and kept in the Laboratory of Herpetology of Butantan Intitute. The venoms were analyzed individually and as a pool of each gender. The assays consisted in protein quantification, 1-DE, mass spectrometry, proteolytic, phospholipase A2, L-amino acid oxidase activities, minimum coagulant dose upon plasma, minimum hemorrhagic dose and lethal dose 50%. Results: Electrophoretic profiles of male’s and female’s venom pools were quite similar, with minor sex-based variation. Male venom showed higher LAAO, PLA2 and hemorrhagic activities, while female venom showed higher coagulant activity. On the other hand, the proteolytic activities did not show statistical differences between pools, although some individual variations were observed. Meanwhile, proteomic profile revealed 112 different protein compounds; of which 105 were common proteins of female’s and male’s venom pools and seven were unique to females. Despite individual variations, lethality of both pools showed similar values. Conclusion: Although differences between female and male venoms were observed, our results show that individual variations are significant even between siblings, highlighting that biological activities of venoms and its composition are influenced by other factors beyond gender.

https://doi.org/10.1590/1678-9199-jvatitd-2020-0018 1232 downloads

11.

Geographic variation of individual venom profile of Crotalus durissus snakes
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Silva-Júnior, Leandro Norberto da

; Abreu, Lara de Souza

; Rodrigues, Caroline Fabri Bittencourt

; Galizio, Nathália da Costa

; Aguiar, Weslei da Silva

; Serino-Silva, Caroline

; Santos, Valdomiro Souza dos

; Costa, Isabella Alves

; Oliveira, Luis Vicente Franco

; Sant’Anna, Sávio Stefanini

; Grego, Kathleen Fernandes

; Tanaka-Azevedo, Anita Mitico

; Rodrigues, Leandro Nascimento da Silva

; Morais-Zani, Karen de

Journal of Venomous Animals and Toxins including Tropical Diseases

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2020, Volume 26 elocation e20200016

Abstract: En | Text: En | PDF: En

Abstract Background: South American rattlesnakes are represented in Brazil by a single species, Crotalus durissus, which has public health importance due to the severity of its envenomation and to its wide geographical distribution. The species is subdivided into several subspecies, but the current classification is controversial. In Brazil, the venoms of C. d. terrificus and C. d. collilineatus are used for hyperimmunization of horses for antivenom production, even though the distinction of these two subspecies are mostly by their geographical distribution. In this context, we described a comparative compositional and functional characterization of individual C. d. collilineatus and C. d. terrificus venoms from three Brazilian states. Methods: We compared the compositional patterns of C. d. terrificus and C. d. collilineatus individual venoms by 1-DE and RP-HPLC. For functional analyzes, the enzymatic activities of PLA2, LAAO, and coagulant activity were evaluated. Finally, the immunorecognition of venom toxins by the crotalic antivenom produced at Butantan Institute was evaluated using Western blotting. Results: The protein profile of individual venoms from C. d. collilineatus and C. d. terrificus showed a comparable overall composition, despite some intraspecific variation, especially regarding crotamine and LAAO. Interestingly, HPLC analysis showed a geographic pattern concerning PLA2. In addition, a remarkable intraspecific variation was also observed in PLA2, LAAO and coagulant activities. The immunorecognition pattern of individual venoms from C. d. collilineatus and C. d. terrificus by crotalic antivenom produced at Butantan Institute was similar. Conclusions: The results highlighted the individual variability among the venoms of C. durissus ssp. specimens. Importantly, our data point to a geographical variation of C. durissus ssp. venom profile, regardless of the subspecies, as evidenced by PLA2 isoforms complexity, which may explain the increase in venom neurotoxicity from Northeastern through Southern Brazil reported for the species.

https://doi.org/10.1590/1678-9199-jvatitd-2020-0016 1034 downloads

12.

THE EFFECT OF PLYOMETRIC TRAINING ON VERTICAL JUMP PERFORMANCE IN YOUNG BASKETBALL ATHLETES
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Correia, Gustavo Augusto Fernandes

; Freitas Júnior, Carlos Gilberto de

; Lira, Hugo Augusto Alvares da Silva

; Oliveira, Saulo Fernandes Melo de

; Santos, Wlaldemir Roberto dos

; Silva, Camilla Karen de Farias Bezerra da

; Silva, Paulo Henrique Vaz da

; Paes, Pedro Pinheiro

Journal of Physical Education

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2020, Volume 31 elocation e3175

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Este estudo investigou o efeito do treinamento pliométrico (TP) no salto vertical em atletas jovens de basquete. Participaram 39 atletas, divididos em dois grupos experimentais (masculino - GEM e feminino - GEF) e dois grupos controle (masculino - GCM e feminino - GCF). O aplicativo My Jump quantificou a altura do salto a partir do tempo de voo. Para análise dos dados utilizou-se anova de medidas repetidas, tamanho de efeito de Cohen (TE) e a inferência baseada na magnitude, com nível de significância (p≤ 0,05). Os resultados indicam que o GEM e GCM apresentaram melhoras significativas no countermovement jump (CMJ) e squart jump (SJ). O GEF e GCF apresentaram diferenças significativas no SJ com efeito de interação, no CMJ apenas o GEF apresentou melhoras com efeito de interação. No TE, o GEM apresentou maiores efeitos no CMJ e SJ quando comparado ao GCM, no GEF, o TE foi maior somente no CMJ em relação ao GCF. As respostas qualitativas mostraram que o TP é provavelmente benéfico no GEM, já no GEF, mostrou que é provavelmente benéfico no SJ e muito provavelmente benéfico no CMJ. Conclui-se que o TP promoveu efeitos positivos no GEM e GEF, tanto no CMJ quanto no SJ. Nos grupos controles, ambos obtiveram melhorias significativas no SJ, porém no CMJ, somente o GCM apresentou aumento. Ademais, os resultados foram maiores no GEM e GEF em comparação com o GCM e GCF. Assim, o TP é indicado para potencializar o salto vertical em atletas jovens de basquete.

ABSTRACT This study investigated the effect of plyometric training (PT) on vertical jump in young basketball athletes. A total of 39 athletes were divided into two experimental groups (male - MEG and female - FEG) and two control groups (male - MCG and female - FCG). The My Jump app quantified jump height from flight time. Data analysis relied on repeated measures ANOVA, Cohen's effect size (ES) and magnitude-based inference, with a level of significance of p≤ 0.05. Results showed that the MEG and the MCG obtained significant improvements in the countermovement jump (CMJ) and in the squat jump (SJ). The FEG and the FCG presented significant differences in the SJ, with interaction effect; as for the CMJ, only the FEG showed improvements with interaction effect. Concerning ES, the MEG showed greater effects in the CMJ and in the SJ compared to the MCG; within the FEG, the ES was greater only for the CMJ in comparison with the FCG. Qualitative responses showed that PT is likely beneficial for the MEG, whereas for the FEG it is likely beneficial in the SJ, and very likely beneficial in the CMJ. It is concluded that PT brought about positive effects on the MEG and on the FEG, both in the CMJ and in the SJ. In the control groups, both obtained significant improvements in the SJ, but only the MCG showed an improvement in the CMJ. Furthermore, results were better in the MEG and in the FEG compared to the MGC and to the FCG. Thus, PT is suitable for vertical jump enhancement in young basketball athletes.

https://doi.org/10.4025/jphyseduc.v31i1.3175 850 downloads

13.

Actividad antimutagénica e identificación de compuestos antioxidantes en la planta Poincianella bracteosa (Fabaceae)
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Couto, Anna Catharina Feitosa

; Araújo, Irlana Karen de Pinho

; Lopes, Alyne Pereira

; Couto, Luciana Maria Fortes Magalhães Castelo Branco

; Santos, Pedro Igor Barros

; Sousa, Regina Maria Silva

; Costa, Maria Wlly da Silva

; Nascimento, Francisco Danilo Fernandes do

; Oliveira, Maria das Dores Alves de

; Costa Júnior, Joaquim Soares da

; Martins, Francielle Alline

; Almeida, Pedro Marcos

Revista de Biología Tropical

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dec 2019, Volume 67 N. 6 Pages 1103 - 1113

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

Resumen Introducción: Poincianella bracteosa (Tul.) L.P. Queiroz. (Fabaceae), conocida como catingueira, es tradicionalmente utilizada en la medicina para tratar diarrea, hepatitis y anemia. Sin embargo, no hay estudios sobre los efectos tóxico genéticos de la P. bracteosa. Objetivo: En el presente estudio se tuvo como objetivo investigar el perfil fitoquímico y el potencial mutagénico y antimutagénico del extracto acuoso de la cáscara de P. bracteosa en Allium cepa y Mus musculus. Métodos: El extracto de la cáscara fue diluido en agua destilada para fornecer las cuatro concentraciones (2, 4, 8 y 16 mg/ml) utilizadas en el bioensayo A. cepa y las tres dosis (10, 20 y 40 mg / Kg) fueron administradas a los ratones (5 animales por grupo). El perfil fito-químico fue realizado por el test colorimétrico para identificar los principales metabólitos secundarios en el extracto de la cáscara. Tras el tratamiento, 5 000 células meristemáticas fueron analizadas para determinar el índice mitótico, el promedio de alteraciones cromosómicas y el porcentaje de reducción de daños. Para ratones, tras 24, 48 y 72 h, la sangre de la cola de cada animal fue recolectado para la preparación de dos láminas por animal. Para cada animal, 2 000 eritrocitos normocromáticos por ratón fueron evaluados para establecer el número de micronúcleos y el efecto protector. Se analizaron los dados por el test de Kruskal-Wallis (P < 0.05). El estudio fito-químico del extracto detectó azúcares reductores y taninos. Resultados: Ninguna de las concentraciones del extracto fue citotóxica y en todos los tratamientos (pre, simultáneo y después) fue observado el efecto citoprotetor en A. cepa. El promedio total de las alteraciones cromosómicas en todas las concentraciones apuntó actividad no mutagénica de la cáscara. El porcentaje de reducción del daño fue observada en los tratamientos pre (de 77.6 al 90.5 %), simultáneo (del 95.6 al 114.7 %) y tras (de 84.8 al 117.7 %). En los ratones, ninguna de las dosis del extracto presentó efecto mutagénico y el porcentaje de reducción del daño osciló de -21.2 al 78.6 % (pre); de 27.5 al 101.3 % (simultánea) y de 85.5 al 120.6 % (tras-tratamiento). Probablemente, los fito-químicos presentes en el extracto no interfirieron en el ciclo celular (A. cepa), tampoco causaron daños al DNA (A. cepa y ratones) y presentaron efecto protector en las dos especies estudiadas. Los datos observados apuntan la importancia del extracto de la cáscara de P. bracteosa para inhibición del daño y quimio prevención. Sin embargo, más estudios deben ser realizados para garantizar su efecto protector sobre el material genético.

ABSTRACT Introduction: Poincianella bracteosa (Tul.) L.P. Queiroz. (Fabaceae), known as catingueira, is traditionally used in medicine to treat diarrhea, hepatitis and anemia. However, there are no studies on their toxicogenetic effects. Objective: The present study aimed to investigate the phytochemical profile as well as the mutagenic and antimutagenic potential of P. bracteosa aqueous bark extract in Allium cepa and Mus musculus. Methods: The extract from barks was diluted in distilled water to yield the four concentrations (2, 4, 8 and 16 mg/ml) used in the A. cepa bioassay and the three doses (10, 20 and 40 mg/Kg) administered to the mice (five animals per group). The phytochemical profile was performed by the colorimetric test to identify the main secondary metabolites in the bark extract. After treatment, five-thousand meristematic cells were analyzed to determine the mitotic index, the mean number of chromosome alterations and the percentage of damage reduction. For mice, after 24, 48 and 72 h, tail blood was collected from each animal for the preparation of two slides per animal. For each animal, 2 000 normochromatic erythrocytes per mice were evaluated to establish the number of micronuclei and the protective effect. Data were analyzed by Kruskal-Wallis test (P < 0.05). Results: The phytochemical analysis of the extract detected reducing sugars and tannins. None of the concentrations of extract was cytotoxic and the cytoprotective effect was observed in A. cepa for all treatments (pre-, simultaneous and post-). The total mean of chromosome alterations in all concentrations indicated a non-mutagenic activity of the bark. The percentage of damage reduction was observed in the pre- (77.6 to 90.5 %), simultaneous (95.6 to 114.7 %) and post- (84.8 to 117.7 %) treatments. In mice, none of the dosages of extract presented mutagenic effect and the percentage of damage reduction varied from -21.16 to 78.63 % (pre-); from 27.51 to 101.28 % (simultaneous) and from 85.47 to 120.63 % (post-treatment). Conclusions: Probably, the phytochemicals in the extract did not interfere with the cell cycle (A. cepa) nor caused damage to the DNA (A. cepa and mice), and exhibited protective effect in both studied species. The observed data indicate the importance of P. bracteosa bark extract for the inhibition of damage and chemoprevention. However, more studies should be carried out to ensure its protective effect on the genetic material.

https://doi.org/10.15517/rbt.v67i6.33883

14.

Atualização da Diretriz de Ressuscitação Cardiopulmonar e Cuidados Cardiovasculares de Emergência da Sociedade Brasileira de Cardiologia - 2019
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Bernoche, Claudia

; Timerman, Sergio

; Polastri, Thatiane Facholi

; Giannetti, Natali Schiavo

; Siqueira, Adailson Wagner da Silva

; Piscopo, Agnaldo

; Soeiro, Alexandre de Matos

; Reis, Amélia Gorete Afonso da Costa

; Tanaka, Ana Cristina Sayuri

; Thomaz, Ana Maria

; Quilici, Ana Paula

; Catarino, Andrei Hilário

; Ribeiro, Anna Christina de Lima

; Barreto, Antonio Carlos Pereira

; Azevedo Filho, Antonio Fernando Barros de

; Pazin Filho, Antonio

; Timerman, Ari

; Scarpa, Bruna Romanelli

; Timerman, Bruno

; Tavares, Caio de Assis Moura

; Martins, Cantidio Soares Lemos

; Serrano Junior, Carlos Vicente

; Malaque, Ceila Maria Sant’Ana

; Pisani, Cristiano Faria

; Batista, Daniel Valente

; Leandro, Daniela Luana Fernandes

; Szpilman, David

; Gonçalves, Diego Manoel

; Paiva, Edison Ferreira de

; Osawa, Eduardo Atsushi

; Lima, Eduardo Gomes

; Adam, Eduardo Leal

; Peixoto, Elaine

; Evaristo, Eli Faria

; Azeka, Estela

; Silva, Fabio Bruno da

; Wen, Fan Hui

; Ferreira, Fatima Gil

; Lima, Felipe Gallego

; Fernandes, Felipe Lourenço

; Ganem, Fernando

; Galas, Filomena Regina Barbosa Gomes

; Tarasoutchi, Flavio

; Souza, Germano Emilio Conceição

; Feitosa Filho, Gilson Soares

; Foronda, Gustavo

; Guimarães, Helio Penna

; Abud, Isabela Cristina Kirnew

; Leite, Ivanhoé Stuart Lima

; Linhares Filho, Jaime Paula Pessoa

; Moraes Junior, João Batista de Moura Xavier

; Falcão, João Luiz Alencar de Araripe

; Ramires, Jose Antônio Franchini

; Cavalini, José Fernando

; Saraiva, José Francisco Kerr

; Abrão, Karen Cristine

; Pinto, Lecio Figueira

; Bianchi, Leonardo Luís Torres

; Lopes, Leonardo Nícolau Geisler Daud

; Piegas, Leopoldo Soares

; Kopel, Liliane

; Godoy, Lucas Colombo

; Tobase, Lucia

; Hajjar, Ludhmila Abrahão

; Dallan, Luís Augusto Palma

; Caneo, Luiz Fernando

; Cardoso, Luiz Francisco

; Canesin, Manoel Fernandes

; Park, Marcelo

; Rabelo, Marcia Maria Noya

; Malachias, Marcus Vinícius Bolívar

; Gonçalves, Maria Aparecida Batistão

; Almeida, Maria Fernanda Branco de

; Souza, Maria Francilene Silva

; Favarato, Maria Helena Sampaio

; Carrion, Maria Julia Machline

; Gonzalez, Maria Margarita

; Bortolotto, Maria Rita de Figueiredo Lemos

; Macatrão-Costa, Milena Frota

; Shimoda, Mônica Satsuki

; Oliveira-Junior, Mucio Tavares de

; Ikari, Nana Miura

; Dutra, Oscar Pereira

; Berwanger, Otávio

; Pinheiro, Patricia Ana Paiva Corrêa

; Reis, Patrícia Feitosa Frota dos

; Cellia, Pedro Henrique Moraes

; Santos Filho, Raul Dias dos

; Gianotto-Oliveira, Renan

; Kalil Filho, Roberto

; Guinsburg, Ruth

; Managini, Sandrigo

; Lage, Silvia Helena Gelas

; Yeu, So Pei

; Franchi, Sonia Meiken

; Shimoda-Sakano, Tania

; Accorsi, Tarso Duenhas

; Leal, Tatiana de Carvalho Andreucci

; Guimarães, Vanessa

; Sallai, Vanessa Santos

; Ávila, Walkiria Samuel

; Sako, Yara Kimiko

Arquivos Brasileiros de Cardiologia

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sep 2019, Volume 113 N. 3 Pages 449 - 663

Abstract: Pt | Text: Pt | PDF: Pt

https://doi.org/10.5935/abc.20190203 54793 downloads

15.

Chorioallantoic urothelial tumor avatar. A clinical tool for phenotype-based therapy
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Ossick, Marina Vian

; Ferrari, Karen Linares

; Nunes-Silva, Igor

; Denardi, Fernandes

; Reis, Leonardo Oliveira

Acta Cirúrgica Brasileira

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2019, Volume 34 N. 12 elocation e201901207

Abstract: En | Text: En | PDF: En

Abstract In the muscle invasive bladder cancer (MIBC) standard of care treatment only patients presenting a major pathological tumor response are more likely to show the established modest 5% absolute survival benefit at 5 years after cisplatin-based neoadjuvant chemotherapy (NAC). To overcome the drawbacks of a blind NAC (i.e. late cystectomy with unnecessary NAC adverse events) with potential to survival improvements, preclinical models of urothelial carcinoma have arisen in this generation as a way to pre-determine drug resistance even before therapy is targeted. The implantation of tumor specimens in the chorioallantoic membrane (MCA) of the chicken embryo results in a high-efficiency graft, thus allowing large-scale studies of patient-derived “tumor avatar”. This article discusses a novel approach that exploits cancer multidrug resistance to provide personalized phenotype-based therapy utilizing the MIBC NAC dilemma.

https://doi.org/10.1590/s0102-865020190120000007 693 downloads

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