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ABSTRACT Objective Currently programmed cell death protein 1 (PD-1) inhibitors in combination with other therapies are being evaluated to determine their efficacy in cancer treatment. However, the effect of PD-ligand (L) 1 expression on disease outcomes in stage III (EC III) non-small cell lung cancer is not completely understood. Therefore, this study aimed to assess the influence of PD-L1 expression on the outcomes of EC III non-small cell lung cancer. Methods This study was conducted on patients diagnosed with EC III non-small cell lung cancer who underwent treatment at a tertiary care hospital. PD-L1 expression was determined using immunohistochemical staining, all patients expressed PD-L1. Survival was estimated using the Kaplan-Meier method. Relationships between variables were assessed using Cox proportional regression models. Results A total of 49 patients (median age=69 years) with EC III non-small cell lung cancer and PD-L1 expression were evaluated. More than half of the patients were men, and most were regular smokers. The patients were treated with neoadjuvant chemotherapy, surgery, or sequential or combined chemotherapy and radiotherapy. The median progression-free survival of the entire cohort was 14.2 months, and the median overall survival was 20 months. There was no significant association between PD-L1 expression and disease progression, clinical characteristics, or overall survival. Conclusions PD-L1 expression was not correlated with EC III non-small cell lung cancer outcomes. Whether these findings differ from the association with immune checkpoint inhibitors remains to be addressed in future studies. PD1 PD (PD-1 However PDligand ligand L (L nonsmall non small understood Therefore PDL1 PDL L1 PD-L hospital staining PDL1. L1. KaplanMeier Kaplan Meier method models 4 age69 age 69 age=6 years men smokers surgery radiotherapy progressionfree progression free 142 14 2 14. months characteristics studies (PD- age6 6 age= (PD

https://doi.org/10.31744/einstein_journal/2024ao0575

Efficacy and Safety of Laparoscopic Endoscopic Cooperative Surgery in Upper Gastrointestinal Lesions: A Systematic Review and Meta-Analysis
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Brito, Sara Oliveira de

; Libânio, Diogo

; Pinto, Cláudia Martins Marques

; Teixeira, João Pedro Pinho Osório de Araújo

; Teixeira, João Paulo Meireles de Araújo

GE-Portuguese Journal of Gastroenterology

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feb 2023, Volume 30 N. 1 Pages 4 - 19

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract Background and Aims: Laparoscopic and endoscopic cooperative surgery (LECS) combines advantages of endoscopy and laparoscopy in order to resect upper gastrointestinal lesions. Our aim was to evaluate the efficacy and safety of LECS in patients with EGJ (esophagogastric junction), gastric and duodenal lesions, as well as to compare LECS with pure endoscopic and pure laparoscopic procedures. Methods: PubMed, Scopus, and ISI Web of Knowledge were searched. Efficacy (R0, recurrence) and safety (conversion rate, procedure and hospitalization time, adverse events, mortality) outcomes were extracted and pooled (odds ratio or mean difference) using a random-effects model. Study quality was assessed with Newcastle-Ottawa Scale and heterogeneity by Cochran’s Q test and I2 . Subgroup analysis according to location was performed. Results: This meta-analysis included 24 studies/1,336 patients (all retrospective cohorts). No significant differences were found between LECS and preexisting techniques (endoscopic submucosal dissection (ESD)/laparoscopy) regarding any outcomes. However, there was a trend to shorter hospitalization time, longer procedure duration, and fewer adverse events in LECS versus Laparoscopy and ESD. R0 tended to be higher in the LECS group. Hospitalization time was significantly shorter in gastric versus EGJ lesions (mean 7.3 vs. 13.7 days, 95% CI: 6.6-7.9 vs. 8.9-19.3). There were no significant differences in conversion rate, adverse events, or mean procedural time according to location. There was a trend to higher conversion rate and longer procedure durations in EGJ and higher rate of adverse events in duodenal lesions. Conclusion: LECS is a valid, safe, and effective treatment option in patients with EGJ, gastric, and duo-denal lesions, although existing studies are retrospective and prone to selection bias. Prospective studies are needed to assess if LECS is superior to established techniques. Key Messages: LECS is safe and effective in the treatment of upper gastrointestinal lesions, but there is no evidence of superiority over established techniques.

Resumo Introdução e objetivos: A Cirurgia cooperativa laparoscópica e endoscópica (LECS) combina vantagens da endoscopia e laparoscopia na resseção de lesões gastrointestinais superiores. O nosso objetivo é avaliar a eficácia e segurança da LECS em pacientes com lesões na junção esofagogástrica (EGJ), estômago e duodeno, e comparar a LECS com procedimentos puramente endoscópicos e laparoscópicos. Métodos: PubMed, Scopus, ISI Web of Knowledge foram pesquisadas. Dados sobre eficácia (R0, recorrência) e segurança (taxa de conversão, duração do procedimento e hospitalização, recorrência, eventos adversos, mortalidade) foram colhidos e agrupados (odds ratio ou média das diferenças), usando modelo de efeitos randomizados. Qualidade dos estudos foi avaliada pela Escala Newcastle-Ottawa e heterogeneidade pelos testes Q da Cochran e I2. Foi realizada análise de subgrupos, consoante a localização. Resultados: Esta meta-análise incluiu 24 estudos/1336 pacientes (todos coortes retrospetivos). Não encontramos diferenças significativas entre LECS e as técnicas pré-existentes (Dis-seção endoscópica da submucosa (ESD)/Laparoscopia) em nenhum aspeto. Porém, encontramos uma tendência para hospitalização mais curta, procedimentos mais longos e menos efeitos adversos na LECS versus Laparoscopia e ESD. R0 tende a ser maior no grupo LECS. Hospitalização foi significativamente menor em lesões gástricas versus EGJ (média 7.3 vs. 13.7 dias, 95% CI: 6.6-7.9 vs. 8.9-19.3). Não encontramos diferenças significativas na taxa de conversão, eventos adversos nem tempo médio de procedimento. Porém encontramos uma tendência para taxas de conversão maiores e procedimentos mais lon-gos na EGJ e maior taxa de eventos adversos no duodeno. Conclusão: LECS é um tratamento válido, seguro e eficaz em pacientes com lesões na EGJ, estômago e duodeno, apesar dos estudos retrospetivos existentes estarem propensos a viés de seleção. São necessários estudos prospetivos para avaliar a superioridade da LECS face às técnicas existentes. Mensagens-chave: LECS é um tratamento seguro e eficaz para lesões gastrointestinais superiores, mas sem evidência de superioridade face às técnicas existentes.

https://doi.org/10.1159/000526644

Systematic review of pharmacological management in Creutzfeldt-Jakob disease: no options so far? CreutzfeldtJakob Creutzfeldt Jakob disease far
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Miranda, Luiz Henrique Lélis

; Oliveira, André Felipe Pastick de Holanda

; Carvalho, Davi Mariano de

; Souza, Gustavo Marques Figueredo

; Magalhães, João Guilherme Monteiro

; Cabral Júnior, Joselmo Alberto

; Lima, Pedro Thadeu Mertens Brainer de Queiroz

; Aguiar Júnior, Renato Melo

; Lins Filho, Sérgio Pereira

; Melo, Hugo Moura de Albuquerque

Arquivos de Neuro-Psiquiatria

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aug 2022, Volume 80 N. 8 Pages 837 - 844

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Antecedentes A doença de Creutzfeldt-Jakob (DCJ) é uma encefalopatia espongiforme que se manifesta como síndrome demencial rapidamente progressiva. Atualmente, a DCJ não possui cura e muitos pacientes morrem no primeiro ano de doença, mas alguns medicamentos vêm sendo estudados como opções no manejo desta condição. Objetivo Avaliar a eficácia dos tratamentos farmacológicos oferecidos aos pacientes com DCJ no aumento de sobrevida e na redução da deterioração cognitiva. Métodos Foi realizada uma revisão sistemática da literatura utilizando 4 revisores independentes e 1 extra para resolver divergências eventuais na busca e na análise de trabalhos indexados nas bases de dados MedLINE (via PubMed), SciELO e Lilacs. Os termos Medical Subjects Heading (MeSH) utilizados foram: prion diseases, creutzfeldt jakob disease, pharmacologic therapy, therapeutics, quinacrine, doxycycline, flupirtine e pentosan polysulfate, com os operadores booleanos AND e OR. Essa pesquisa incluiu ensaios clínicos controlados, não controlados e séries de casos, publicados a partir do ano 2000 no idioma inglês. Resultados Ao todo, foram encontrados 85 trabalhos através dos descritores utilizados. Ao final das análises de seleção, restaram 9 artigos, que foram analisados na íntegra individualmente. Conclusões Nenhuma das drogas avaliadas se mostrou significativamente eficaz no aumento da sobrevida dos pacientes com DCJ. A flupirtina parece ter um efeito benéfico na redução da deterioração cognitiva dos pacientes com DCJ. Entretanto, estudos adicionais são necessários para o estabelecimento de melhores evidências e opções terapêuticas para o manejo dos pacientes com DCJ. CreutzfeldtJakob Creutzfeldt Jakob (DCJ progressiva Atualmente condição via PubMed, PubMed , PubMed) Lilacs MeSH (MeSH diseases disease therapy therapeutics quinacrine doxycycline polysulfate OR casos 200 inglês todo 8 seleção artigos individualmente Entretanto 20 2

Abstract Background The Creutzfeldt-Jakob disease (CJD) is a spongiform encephalopathy that manifests as a rapidly progressive dementia syndrome. Currently, CJD has no cure, and many patients die within the first year, but some drugs are being studied as options for managing this condition. Objective To evaluate the effectiveness of pharmacological treatments offered to patients with CJD as a means to increase survival and reduce cognitive deterioration. Methods A systematic review of the literature was performed using 4 independent reviewers and 1 extra reviewer to resolve possible divergences in the search and analysis of papers indexed in MedLINE (PubMed), SciELO and Lilacs databases. The Medical Subject Heading (MeSH) terms used were: prion diseases, Creutzfeldt-Jakob disease, pharmacologic therapy, therapeutics, quinacrine, doxycycline, flupirtine, and pentosan polysulfate, with the Boolean operators AND and OR. This search included controlled clinical trials, uncontrolled clinical trials, and case series published from the year 2000 onwards, in the English language. Results A total of 85 papers were found using the descriptors used. At the end of the selection analyses, 9 articles remained, which were analyzed fully and individually. Conclusions None of the drugs evaluated proved significantly effective in increasing survival in patients with CJD. Flupirtine appears to have a beneficial effect in reducing cognitive deterioration in patients with CJD. However, additional studies are needed to establish better evidence and therapeutic options for the management of patients with CJD. CreutzfeldtJakob Creutzfeldt Jakob (CJD syndrome Currently cure condition PubMed, PubMed , (PubMed) databases MeSH (MeSH diseases therapy therapeutics quinacrine doxycycline flupirtine polysulfate OR trials 200 onwards language 8 analyses remained individually However (PubMed 20 2

https://doi.org/10.1055/s-0042-1755341

Fruit quality and genetic diversity of Spondias dulcis accessions
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Souza, Pedro Henrique Magalhães de

; Monteiro, Victoria Azevedo

; Rodrigues, Cláudia Dayane Marques

; Gomes, Francielly Rodrigues

; Oliveira, João Alison Alves

; Silva, Danielle Fabíola Pereira da

Revista Ceres

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apr 2022, Volume 69 N. 2 Pages 180 - 186

Abstract: En | Text: En | PDF: En

ABSTRACT Among the less exploited Brazilian native fruit trees, the Spondias dulcis (cajá-manga) has many uses, being their fruits appreciated in fresh consumption and its pulp used in popsicles, ice-creams, and jellies production. However, there is a lack of research on this species, being necessary more studies. This work aimed to characterize the physical and chemical quality and the genetic diversity of Spondias dulcis fruits harvested in different accessions in the municipality of Jataí - GO. The experiment was carried out in a completely randomized design with six treatments (accessions), ten replications with ten fruits per plot, totaling a sample of 600 fruits. The fruits were evaluated for pulp and peel color, pulp yield, soluble solids content, titratable acidity, soluble solids content/titratable acidity ratio, and vitamin C content. The fruits from accessions M4 and M5 presented physical and chemical characteristics higher than the other plants. The evaluated accessions presented genetic variability, being the methodology employed efficiently to indicate this variability, in which the accession M2 was the most divergent.

https://doi.org/10.1590/0034-737x202269020008

Prevalence of COVID-19 in medical school and residency in Porto Alegre, RS COVID19 COVID 19 COVID-1 Alegre COVID1 1 COVID-
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Silva, Gabriela Salzano

; Avila, Georgia Oliveira

; Lubianca, Fernanda Nascimento

; Lubianca, João Pedro Neves

; Michelon, Victória Marques de Medeiros

; Kalil, Diogo Pereira

; Maestri, Lorenzo Feldman

; Lengler, Arthur Dementshuk

; Lima, Guilherme Pereira

; Lubianca Neto, José Faibes

Revista da Associação Médica Brasileira

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feb 2022, Volume 68 N. 2 Pages 206 - 211

Abstract: En | Text: En | PDF: En

SUMMARY OBJECTIVE: A multicentric, cross-sectional study was carried out to determine the prevalence and risk factors for Coronavirus disease 2019 in medical students and residents from four universities and affiliated hospitals in Brazil. METHODS: A survey about contamination risk and symptoms was sent to all participants through email and WhatsApp. Prevalence was measured by the self-report of positive polymerase chain reaction or serological test. Univariate and multivariate analyses were performed, and odds ratio and 95% confidence interval were calculated. RESULTS: Prevalence of infection by Sars-CoV-2 was 14.9% (151/1011). The disease was more prevalent in residents and interns than in undergraduate students. Contact with an infected relative outside the hospital or with colleagues without using personal protective equipment was associated with higher contamination. Contact with patients without wearing goggles and higher weekly frequency of contact were the two factors independently associated with the infection by Coronavirus disease 2019 in the multivariate analysis. CONCLUSIONS: Medical students, interns, and residents have a higher prevalence of Coronavirus disease 2019 than the general population, in which the last two groups are significantly at higher risk. Contacting patients at a higher weekly frequency increases the risk for infection. The use of goggles should be reinforced when contacting patients. OBJECTIVE multicentric crosssectional cross sectional 201 Brazil METHODS WhatsApp selfreport self report test performed 95 calculated RESULTS SarsCoV2 SarsCoV Sars CoV 2 Sars-CoV- 149 14 9 14.9 151/1011. 1511011 151/1011 . 151 1011 (151/1011) analysis CONCLUSIONS population 20 Sars-CoV 1 14. 151101 151/101 15 101 (151/1011 15110 151/10 10 (151/101 1511 151/1 (151/10 151/ (151/1 (151/ (151 (15 (1 (

https://doi.org/10.1590/1806-9282.20211114

Traditional pipe smoking ( xanduca ) and respiratory function in the Fulni-ô indigenous people, Brazil: Project of Atherosclerosis among Indigenous Populations (PAI) study
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Pereira, Vanessa Cardoso

; Coelho, David Lopes Lima Cavalcanti

; Santos, Juracy Marques dos

; Armstrong, Dinani Matoso Fialho de Oliveira

; Patriota, Pedro Vinícius Amorim de Medeiros

; Lima, João Augusto Costa

; Cruz, Álvaro Augusto

; Carmo, Rodrigo Feliciano do

; Souza, Carlos Dornels Freire de

; Armstrong, Anderson da Costa

Jornal Brasileiro de Pneumologia

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2022, Volume 48 N. 2 elocation e20210468

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.36416/1806-3756/e20210468

Avaliação da qualidade da Atenção Primária à Saúde em Fortaleza, Brasil, na perspectiva dos usuários adultos no ano de 2019
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Costa, Lourrany Borges

; Mota, Maria Vaudelice

; Porto, Magda Moura de Almeida

; Fernandes, Carla Salles Gazeta Vieira

; Santos, Eveline Torquato

; Oliveira, João Pedro Marques de

; Mota, Thayná Custódio

; Porto, Andrea Lima da Silva

; Alencar, Maria Nice Almeida

Ciência & Saúde Coletiva

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jun 2021, Volume 26 N. 6 Pages 2083 - 2096

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo A Atenção Primária à Saúde (APS) é porta de entrada e eixo estruturante do Sistema de Saúde brasileiro, o que impõe a necessidade de avaliação de sua qualidade. Este estudo objetivou avaliar os serviços públicos de Atenção Básica quanto aos atributos da APS por meio do PCATool na ótica de usuários em Fortaleza. Trata-se de um estudo transversal, de junho a dezembro de 2019, com 233 usuários adultos de 19 Unidades de APS (UAPS). Foram coletados dados sociodemográficos e epidemiológicos dos usuários e sobre a estrutura das UAPS. Utilizou-se modelo multinível para analisar características de usuários e UAPS em relação ao escore de APS medido via PCATool. Participantes foram, na maioria, mulheres, de 30 a 59 anos, pardos, com Ensino Médio completo, sem seguro privado, com moradia própria do tipo casa, de famílias até 4 pessoas. “Acessibilidade” obteve o menor escore, 2,8, e “Utilização” obteve o maior escore, 8,1. O Escore Essencial da APS foi 6,0, enquanto o Escore Geral foi 5,7. Houve influência positiva (p<0,05) no Escore Geral por: equipes completas, maior número de agentes comunitários e presença de residência de Medicina de Família e Comunidade. Concluiu-se que os serviços públicos de Fortaleza avaliados possuem baixo desempenho de APS na ótica dos usuários adultos.

Abstract Primary Health Care (PHC) is the “front door” and keystone of Brazil’s public health system, meaning that the evaluation of the quality of primary care services is of utmost importance. Using the Primary Care Assessment Tool (PCAT), this study evaluated the performance of public PHC services in Fortaleza from the view of adult service users. We conducted a cross-sectional study of 233 adult service users from 19 primary care centers (PCCs) between June and December 2019, collecting data on the sociodemographic and epidemiological characteristics of users and structural features of PCCs. The association between user and PCC characteristics and primary care attribute scores was measured by multilevel logistic regression. Most participants were women, aged between 30 and 59 years, brown, house owners, had completed high school, did not own health insurance, and belonged to families with at least 4 members. The lowest and highest-scoring attributes were “first contact accessibility” and “first contact utilization” (2.8 and 8.1, respectively). The overall essential and general scores were 6.0 and 5.7, respectively. Having complete health teams, more community health workers, and a family and community medicine residency program had a positive effect on the general score (p<0.05). Overall, the public services analyzed in Fortaleza received a low performance rating from the adult service users.

https://doi.org/10.1590/1413-81232021266.39722020

Avaliação da qualidade da Atenção Primária à Saúde em Fortaleza, Brasil, na perspectiva dos usuários adultos no ano de 2019
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Costa, Lourrany Borges

; Mota, Maria Vaudelice

; Porto, Magda Moura de Almeida

; Fernandes, Carla Salles Gazeta Vieira

; Santos, Eveline Torquato

; Oliveira, João Pedro Marques de

; Mota, Thayná Custódio

; Porto, Andrea Lima da Silva

; Alencar, Maria Nice Almeida

Ciência & Saúde Coletiva

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jun 2021, Volume 26 N. 6 Pages 2083 - 2096

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.1590/1413-81232021266.39722020 280 downloads

Realistic simulation is associated with healthcare professionals’ increased self-perception of confidence in providing acute stroke care: a before-after controlled study
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FARIAS DA GUARDA, Suzete Nascimento

; SANTOS, João Pedro Souza

; REIS, Mariana Sampaio Motta

; PASSOS, Rogério da Hora

; CORREIA, Luis Claúdio

; CALDAS, Juliana Ribeiro

; GOBATTO, André Luiz Nunes

; TEIXEIRA, Maurício

; OLIVEIRA, Adelmo

; RIBEIRO, Michel Pordeus

; BATISTA, Paulo Benigno Pena

; CALDERARO, Marcelo

; PASCHOAL JUNIOR, Fernando

; PONTES-NETO, Octávio Marques

; RAMOS, João Gabriel Rosa

Arquivos de Neuro-Psiquiatria

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jan 2021, Volume 79 N. 1 Pages 2 - 7

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Introdução: Simulações são amplamente utilizadas na educação médica, mas há pouca evidência de sua eficácia no tratamento de pacientes neurocríticos. Como o acidente vascular cerebral agudo (AVC) é uma patologia que requer atendimento imediato, o uso de simulação pode ser uma ferramenta útil no treinamento do manejo desses pacientes. Objetivo: Avaliar o impacto do uso de simulação realística na autopercepção de segurança no atendimento a pacientes vítimas de AVC agudo. Métodos: Estudo antes-depois controlado. No grupo da intervenção, 17 profissionais da área de saúde participaram de um curso de simulação realística de atendimento a pacientes com AVC. Como controles, os participantes foram escolhidos a partir de uma amostra de conveniência composta por 18 participantes do curso Emergency Neurologic Life Support (ENLS) e 20 participantes de um curso de Neurossonologia. Foram respondidos questionários antes e após o curso para avaliar a autopercepção de segurança no atendimento a pacientes vítimas de AVC agudo, variando de 10 a 50 pontos. Foi avaliada a variação entre os resultados pré- e pós-teste, para avaliar a mudança na autopercepção de confiança do trainee no manejo do AVC agudo. Análise multivariada foi realizada para controlar possíveis fatores de confusão. Resultados: Quarenta e seis (83,63%) participantes responderam aos questionários. A pontuação no questionário pós-curso foi maior do que a obtida no questionário pré-curso no grupo de participantes do curso de simulação realística em AVC [mediana do questionário pré-curso: 41,5 (36,7-46,5) e mediana do questionário pós-curso: 47,0 (44,7-48,0); p=0,033]. Essa diferença não foi observada no curso de Neurossonologia [mediana pré-curso (IQR): 46,0 (44,0-47,00), mediana pós-curso (IQR): 46,0 (44,0-47,0); p=0,739] nem no ENLS [mediana pré-curso (IQR): 46,5 (39,0-48,2) mediana pós-curso (IQR): 47,0 (40,2-49,0); p=0,317]. Esses resultados persistiram após ajuste das variáveis. Conclusão: O curso de simulação realística em AVC foi associado a um aumento na autopercepção de segurança dos participantes em atender pacientes vítimas de AVC agudo.

ABSTRACT Background: Simulations are becoming widely used in medical education, but there is little evidence of their effectiveness on neurocritical care. Because acute stroke is a neurological emergency demanding prompt attention, it is a promising candidate for simulation training. Objective: To assess the impact of a stroke realistic simulation course on clinicians’ self-perception of confidence in the management of acute stroke. Methods: We conducted a controlled, before-after study. For our intervention, 17 healthcare professionals participated in a stroke realistic simulation course. As controls, participants were chosen from a convenience sample of attendees to the courses Emergency Neurologic Life Support (ENLS) (18 participants) and Neurosonology (20 participants). All participants responded pre- and post-test questionnaires evaluating their self-perception of confidence in acute stroke care, ranging from 10 to 50 points. We evaluated the variation between pre- and post-test results to assess the change on trainees’ self-perception of confidence in the management of acute stroke. Multivariate analysis was performed to control for potential confounders. Results: Forty-six (83.63%) subjects completed both questionnaires. The post-test scores were higher than those from the pretests in the stroke realistic simulation course group [pretest median (interquartile range - IQR): 41.5 (36.7-46.5) and post-test median (IQR): 47 (44.7-48); p=0.033], but not in the neurosonology [pretest median (IQR): 46 (44-47) and post-test median (IQR): 46 (44-47); p=0.739] or the ENLS [pretest median (IQR): 46.5 (39-48.2), post-test median (IQR): 47 (40.2-49); p=0.317] groups. Results were maintained after adjustment for covariates. Conclusions: This stroke realistic simulation course was associated with an improvement on trainees’ self-perception of confidence in providing acute stroke care.

https://doi.org/10.1590/0004-282x-anp-2019-0369 683 downloads

10.

STOP-Bang and NoSAS questionnaires as a screening tool for OSA: which one is the best choice?
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Costa, José Coutinho

; Rebelo-Marques, Alexandre

; Machado, João Pedro Neiva

; Valentim, Bruno Miguel Figueiredo

; Ferreira, Cláudia Sofia de Almeida Vicente

; Gonçalves, Joana Daniela Oliveira

; Gama, Jorge Manuel dos Reis

; Teixeira, Maria de Fátima Lopes

; Moita, Joaquim Jorge Marques

Revista da Associação Médica Brasileira

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sep 2020, Volume 66 N. 9 Pages 1203 - 1209

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO INTRODUÇÃO: Na atualidade tem se verificado um crescimento significativo no número de doentes com suspeita de apneia obstrutiva do sono (AOS) referenciados para consulta do sono. Nesse sentido, instrumentos de rastreio e estratificação da gravidade dessa patologia têm se tornado cada vez mais relevantes. OBJETIVO: Avaliar e comparar o desempenho da escala NoSAS e Stop-Bang para o rastreio de AOS. MÉTODOS: Estudo prospectivo durante 12 meses. Avaliados todos os doentes encaminhados aos cuidados de saúde primários do centro de medicina do sono que completaram o questionário NoSAS (Neck circumference, Obesity, Snoring, Age, Sex), Stop-Bang (Snoring, Tiredness, Observed apnea, Pressure [high blood], BMI, Age, Neck circumference, Gender) e foram submetidos a polissonografia. Utilizou-se uma análise ROC (receiver operating characteristic) para encontrar as pontuações que maximizam simultaneamente a sensibilidade e especificidade para cada diagnóstico. RESULTADOS: Incluídos 294 indivíduos, 84% apresentavam AOS, sendo que em 28,8% a OAS era ligeira, 34,8% moderada e 36,4% grave. USANDO A ESCALA NOSAS PARA PREVISÃO DE AOS, AOS MODERADA A GRAVE E AOS GRAVE, A ÁREA ROC FOI: 0,770 (IC95%: 0,703-0,837), p<0,001, sensibilidade de 57,5% e especificidade de 83,0% para a pontuação 12); 0,746 (IC95%: 0,691- 0,802), p<0,001, sensibilidade de 68,2% e especificidade de 75,4% para a pontuação 13); 0,686 (IC95%: 0,622-0,749), p<0,001, sensibilidade de 71,1% e especificidade de 58,3% para a pontuação 13), respectivamente. USANDO A ESCALA STOP-BANG PARA A PREVISÃO DE AOS, AOS MODERADA A GRAVE E AOS GRAVE, A ÁREA ROC FOI: 0,862 (IC95%: 0,808-0,916), p<0,001, sensibilidade de 68,4% e especificidade de 85,1% para pontuação 5); 0,813 (IC95%: 0,756-0,861), p<0,001, sensibilidade de 77,3% e especificidade de 66,1% para a pontuação 5); 0,787 (IC95%: 0,732-0,841), p<0,001, sensibilidade de 70,0% e especificidade de 79,9% para a pontuação 6), respectivamente. CONCLUSÕES: A área ROC foi consistentemente alta para as duas escalas, confirmando a capacidade diagnóstica dos questionários NoSAS e Stop-Bang para todos os graus de gravidade de AOS. Assim, os nossos resultados sugerem que esses questionários podem ser um importante instrumento para rastreio e estratificação de doentes no diagnóstico de AOS. Globalmente, a capacidade de diagnóstico do Stop-Bang foi superior à do NoSAS.

SUMMARY INTRODUCTION: Currently there has been significant growth in the number of patients with suspected obstructive sleep apnea (OSA) referred to sleep clinics. In this sense, screening and stratification methods of the severity of this pathology have become increasingly relevant. OBJECTIVE: To evaluate the performance of the NoSAS and STOP-Bang scores in the screening of OSA in a sleep clinic. METHODS: Prospectively, for 12 months, all patients referred by primary care physicians to our sleep unit for clinical evaluation and who underwent in-lab polysomnography (PSG), also completed the NoSAS score (Neck circumference, Obesity, Snoring, Age, Sex) and STOP-Bang (Snoring, Tiredness, Observed apnea, Pressure (high blood), BMI, Age, Neck circumference, Gender). A ROC (receiver operating characteristic) analysis was used to find the scores that simultaneously maximize sensitivity and specificity for each diagnosis. RESULTS: Of the 294 individuals included, 84% had OSA, of which 28.8% were mild, 34.8% moderate, and 36.4% were severe. USING THE NOSAS SCORE FOR PREDICTING OSA, MODERATE TO SEVERE OSA, AND SEVERE OSA, THE ROC AREA WAS: 0.770 (95% CI: 0.703-0.837), p<0.001, sensitivity of 57.5%, and specificity of 83.0% for a score of 12; 0.746 (95% CI: 0.691-0.802), p<0.001, sensitivity of 68.2% and specificity of 75.4% for a score of 13; 0.686 (95% CI: 0.622-0.749), p<0.001, sensitivity of 71.1% and specificity of 58.3% for a score of 13, respectively. USING THE STOP-BANG SCORE FOR PREDICTING OSA, MODERATE TO SEVERE OSA, AND SEVERE OSA, THE ROC AREA WAS: 0.862 (95% CI: 0.808-0.916), p<0.001, sensitivity of 68.4% and specificity of 85.1% for a score of 5; 0.813 (95% CI: 0.756-0.861), p<0.001, sensitivity of 77.3% and specificity of 66.1% for a score of 5; 0.787 (95% CI: 0.732-0.841), p<0.001, sensitivity of 70.0% and specificity of 79.9% for a score of 6, respectively. CONCLUSIONS: The ROC area was consistently high for both scores confirming the diagnostic ability of the NoSAS and STOP-Bang questionnaires for all OSA severities. Thus, our results suggest that these questionnaires may be a powerful tool for the screening and stratification of patients in the diagnosis of OSA. Overall, the diagnostic ability of the STOP-Bang was higher than the NoSAS.

https://doi.org/10.1590/1806-9282.66.9.1203 780 downloads

11.

Management of acute stroke and urgent neurointerventional procedures during COVID-19 pandemic: recommendations on the Scientific Department on Cerebrovascular Diseases of the Brazilian Academy of Neurology, Brazilian Society of Cerebrovascular Diseases and Brazilian Society of Neuroradiology
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MONT’ALVERNE, Francisco José Arruda

; LIMA, Fabrício Oliveira

; NOGUEIRA, Raul Gomes

; FREITAS, Carlos Clayton Macedo de

; NETO, Octávio Marques Pontes

; SILVA, Gisele Sampaio

; OLIVEIRA, Maura Salaroli de

; FRUDIT, Michel

; CALDAS, Jose Guilherme Mendes Pereira

; ABUD, Daniel Giansante

; CONFORTO, Adriana Bastos

; CARVALHO, Fernanda Martins Maia

; DIAS, Francisco Antunes

; BAZAN, Rodrigo

; AVELAR, Wagner Mauad

; MORO, Carla Heloísa Cabral

; MAGALHÃES, Pedro Silva Correa de

; MIRANDA, Maramelia

; BARBOSA, Leandro de Assis

; FIOROT JUNIOR, José Antonio

; CARDOSO, Fabrício Buchdid

; REBELLO, Leticia Costa

; PARENTE, Bruno de Sousa Mendes

; FARIA, Mário de Barros

; FREITAS, Gabriel Rodriguez de

; ZÉTOLA, Viviane de Hiroki Flumignan

; OLIVEIRA-FILHO, Jamary

; BEZERRA, Daniel da Cruz

; RODRIGUES, Jorge Luis Nobre

; KUSTER, Gustavo

; MARTINS, Sheila

; CARVALHO, João José Freitas de

Arquivos de Neuro-Psiquiatria

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jul 2020, Volume 78 N. 7 Pages 440 - 449

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Introdução: A pandemia causada pelo novo coronavírus da síndrome respiratória aguda grave 2 (SARS-CoV-2, COVID-19) apresenta novos e importantes desafios à gestão de saúde no Brasil. Além da difícil missão de prestar atendimento aos milhares de pacientes infectados pelo COVID-19, os sistemas de saúde têm que manter a assistência às emergências médicas comuns em períodos sem pandemia, tais como o acidente vascular cerebral (AVC), que continuam ocorrendo e requerem tratamento com presteza e eficiência. A alocação de recursos materiais e humanos para o enfrentamento à pandemia não pode comprometer o atendimento ao AVC agudo, uma emergência cujo tratamento é tempo-dependente e se não realizado implica em importante impacto na mortalidade e incapacitação a longo prazo. Objetivo: Este trabalho resume as recomendações do Departamento Científico de Doenças Cerebrovasculares da Academia Brasileira de Neurologia, da Sociedade Brasileira de Doenças Cerebrovasculares e da Sociedade Brasileira de Neurorradiologia para o tratamento do AVC agudo e para a realização de procedimentos de neurointervenção urgentes durante a pandemia de COVID-19, incluindo o uso adequado de ferramentas de triagem e equipamentos de proteção pessoal (para pacientes e profissionais de saúde), além da alocação apropriada de pacientes.

ABSTRACT Introduction: Although the 2019 severe acute respiratory syndrome coronavirus 2 infection (SARS-CoV-2, COVID-19) pandemic poses new challenges to the healthcare system to provide support for thousands of patients, there is special concern about common medical emergencies, such as stroke, that will continue to occur and will require adequate treatment. The allocation of both material and human resources to fight the pandemic cannot overshadow the care for acute stroke, a time-sensitive emergency that with an inefficient treatment will further increase mortality and long-term disability. Objective: This paper summarizes the recommendations from the Scientific Department on Cerebrovascular Diseases of the Brazilian Academy of Neurology, the Brazilian Society of Cerebrovascular Diseases and the Brazilian Society of Neuroradiology for management of acute stroke and urgent neuro-interventional procedures during the COVID-19 pandemic, including proper use of screening tools, personal protective equipment (for patients and health professionals), and patient allocation.

https://doi.org/10.1590/0004-282x20200053 2310 downloads

12.

Brazilian guidelines for endovascular treatment of patients with acute ischemic stroke
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Pontes-Neto, Octávio Marques

; Cougo, Pedro

; Martins, Sheila Cristina Ouriques

; Abud, Daniel G.

; Nogueira, Raul G.

; Miranda, Maramélia

; Castro-Afonso, Luiz Henrique de

; Rebello, Leticia C.

; Caldas, José Guilherme M. Pereira

; Bazan, Rodrigo

; Bezerra, Daniel C

; Rezende, Marco Tulio

; Freitas, Gabriel R. de

; Longo, Alexandre

; Magalhães, Pedro

; Carvalho, João José Freitas de

; Montalverne, Francisco José

; Lima, Fabricio Oliveira

; Andrade, Gustavo H.V.

; Massaro, Ayrton R.

; Oliveira-Filho, Jamary

; Gagliardi, Rubens

; Silva, Gisele Sampaio

Arquivos de Neuro-Psiquiatria

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jan 2017, Volume 75 N. 1 Pages 50 - 56

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Estas diretrizes são o resultado de um esforço conjunto de membros da Sociedade Brasileira de Doenças Cerebrovasculares (SBDCV), Departamento científico de Doenças Cerebrovasculares da Academia Brasileira de Neurologia (ABN), Rede Brasil AVC (RBAVC) e da Sociedade Brasileira de Neurorradiologia Diagnóstica e Terapêutica (SBNR). Membros destas 4 entidades participaram de fórum de discussões por internet de temas pré-definidos, seguidos de encontros de videoconferência para discussão de pontos controversos e das recomendações, em busca de um consenso final. Estas diretrizes tem seu foco sobre as implicações dos recentes ensaios clínicos de tratamento endovascular do acidente vascular cerebral (AVC) isquêmico agudo relacionado a oclusão de artérias proximais. O texto final foi elaborado para servir de orientação no manejo destes pacientes AVC isquêmico pelos diferentes profissionais de saúde, gestores de saúde pública e de saúde complementar no Brasil.

ABSTRACT These guidelines are the result of a joint effort from writing groups of the Brazilian Stroke Society, the Scientific Department of Cerebrovascular Diseases of the Brazilian Academy of Neurology, the Brazilian Stroke Network and the Brazilian Society of Diagnostic and Therapeutic Neuroradiology. Members from these groups participated in web-based discussion forums with predefined themes, followed by videoconference meetings in which controversies and position statements were discussed, leading to a consensus. This guidelines focuses on the implications of the recent clinical trials on endovascular therapy for acute ischemic stroke due to proximal arterial occlusions, and the final text aims to guide health care providers, health care managers and public health authorities in managing patients with this condition in Brazil.

https://doi.org/10.1590/0004-282x20160174 10346 downloads

13.

Guidelines for acute ischemic stroke treatment: part II: stroke treatment
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Martins, Sheila Cristina Ouriques

; Freitas, Gabriel Rodriguez de

; Pontes-Neto, Octávio Marques

; Pieri, Alexandre

; Moro, Carla Heloísa Cabral

; Jesus, Pedro Antônio Pereira de

; Longo, Alexandre

; Evaristo, Eli Faria

; Carvalho, João José Freitas de

; Fernandes, Jefferson Gomes

; Gagliardi, Rubens José

; Oliveira-Filho, Jamary

Arquivos de Neuro-Psiquiatria

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nov 2012, Volume 70 N. 11 Pages 885 - 893

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

A segunda parte das Diretrizes aborda os tópicos de antiagregantes plaquetários, anticoagulantes e terapia de reperfusão para acidente vascular cerebral (AVC) isquêmico. Os critérios para nível de evidência e graus de recomendação estão contidos na primeira parte do documento. Uma versão traduzida destas Diretrizes encontra-se publicada no portal da Sociedade Brasileira de Doenças Cerebrovasculares (www.sbdcv.org.br).

The second part of these Guidelines covers the topics of antiplatelet, anticoagulant, and statin therapy in acute ischemic stroke, reperfusion therapy, and classification of Stroke Centers. Information on the classes and levels of evidence used in this guideline is provided in Part I. A translated version of the Guidelines is available from the Brazilian Stroke Society website (www.sbdcv.com.br).

26871 downloads

14.

Effects of prokinetic drugs on the abdominal wall wound healing of rats submitted to segmental colectomy and colonic anastomosis
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Morais, Pedro Henrique Alves de

; Silva, Naiara Galvão da

; Oliveira, Marcos Vinícius Melo de

; Brandão, Alexandre Malta

; Silva, Silvana Marques e

; Carneiro, Fabiana Pirani

; Sousa, João Batista de

Acta Cirúrgica Brasileira

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jul 2012, Volume 27 N. 7 Pages 448 - 453

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

OBJETIVO: Avaliar os efeitos do uso de drogas prócinéticas na cicatrização da parede abdominal de ratos submetidos à colectomia segmentar e anastomose no cólon esquerdo. MÉTODOS: Foram utilizados 60 ratos, alocados aleatoriamente em três grupos para receberem as seguintes medicações no período pós-operatório: M (metoclopramida); B (bromoprida) e C (solução salina a 0,9%). Os procedimentos cirúrgicos foram idênticos em todos os animais. Foi realizada laparotomia mediana, seguida de colectomia segmentar de 1-cm e anastomose colônica. O fechamento da parede abdominal foi feito em dois planos de sutura contínua. No 3° ou no 7° dia pós-operatório foram coletadas amostras da parede abdominal para medida da força de ruptura e avaliação histopatológica. RESULTADOS: Não houve diferença significativa entre os grupos no que diz respeito à força de ruptura da parede abdominal, nem entre os subgrupos no 3º e 7º dia após a cirurgia. À análise histopatológica não houve alterações na deposição de colágeno ou na quantidade de fibroblastos no sítio da cicatriz. CONCLUSÃO: O uso de drogas prócinéticas, metoclopramida ou de bromoprida, não interferiu na cicatrização da parede abdominal de ratos submetidos à colectomia segmentar e anastomose no cólon esquerdo.

PURPOSE: To assess the effect of prokinetic agents on abdominal wall wound healing in rats submitted to segmental colectomy and colonic anastomosis. METHODS: Sixty rats were randomly allocated into three groups according to the agents they would receive in the postoperative period: M (metoclopramide); B (bromopride); and C (control, saline 0.9%). Surgical procedures were performed identically in all animals, and consisted of a midline laparotomy followed by resection of a 1-cm segment of large bowel with end-to-end anastomosis. The abdominal wall was closed in two layers with running stitches. Abdominal wall samples were collected on the 3rd or 7th postoperative day for measurement of breaking (tensile) strength and histopathological assessment. RESULTS: There were no statistically significant differences in tensile strength of the abdominal wall scar between groups M, B, and C, nor between the three and seven days after surgery subgroups. On histopathological assessment, there were no statistically significant between-group differences in collagen deposition or number of fibroblasts at the wound site CONCLUSION: Use of the prokinetic drugs metoclopramide or bromopride had no effect on abdominal wall healing in rats submitted to segmental colectomy and colonic anastomosis.

2490 downloads

15.

Effects of bromopride on the healing of left colonic anastomoses in rats with induced abdominal sepsis
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Silva, Silvana Marques e

; Carneiro, Fabiana Pirani

; Oliveira, Paulo Gonçalves de

; Morais, Pedro Henrique Alves de

; Silva, Naiara Galvão da

; Sousa, João Batista de

Acta Cirúrgica Brasileira

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jun 2012, Volume 27 N. 6 Pages 370 - 375

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

OBJETIVO: Avaliar os efeitos da bromoprida sobre a cicatrização de anastomoses de cólon esquerdo de ratos na presença de sepse abdominal. MÉTODOS: Quarenta ratos distribuídos em grupos contendo 20 animais para administração de bromoprida ou salina. Cada grupo foi dividido em subgrupos contendo dez animais, para eutanásia no terceiro ou no sétimo dia de pós-operatório. A indução da sepse foi realizada pelo método de ligadura e punção do ceco. Foi realizada ressecção de um segmento do cólon esquerdo e anastomose término-terminal. À re-laparotomia, foi avaliada a quantidade total de aderências e removido um segmento colônico contendo a anastomose para análise histopatológica, força de ruptura, concentração de hidroxiprolina e histomorfometria do colágeno. RESULTADOS: No 3° DPO, as anastomoses dos animais tratados com bromoprida apresentaram menor força de ruptura (p=0,02) e maior redução da concentração de hidroxiprolina (p=0,04) que os animais controle. Não houve diferença estatística quanto a estes parâmetros no 7° DPO. O conteúdo de colágeno foi semelhante entre os subgrupos. CONCLUSÃO: Na presença de sepse abdominal, o uso da bromoprida esteve associado à diminuição da força de ruptura e da concentração de hidroxiprolina das anastomoses do cólon esquerdo de ratos no 3° DPO.

PURPOSE: To evaluate the effects of bromopride on the healing of left colonic anastomoses in rats with induced abdominal sepsis. METHODS: Forty rats were divided into two groups to receive either bromopride (experimental group- E) or saline (control group- C). Each group was divided into subgroups of ten animals each to be euthanized on third (E3 and C3) or seventh day (E7 and C7) after surgery. Sepsis was induced by cecal ligation and puncture. The rats underwent segmental left colon resection and end-to-end anastomosis. Adhesion formation, tensile strength and hydroxyproline concentration were assessed. Histomorphometry of collagen and histopathological analysis were also performed. RESULTS: On postoperative third day, anastomoses in bromopride-treated animals showed lower tensile strength (p=0.02) and greater reduction in hydroxyproline concentration (p=0.04) than in control animals. There was no statistical difference in these parameters on seventh day, and the remaining parameters were similar across subgroups. Collagen content was also similar across subgroups. CONCLUSION: In the presence of abdominal sepsis, the administration of bromopride was associated with decreased tensile strength and hydroxyproline concentration in left colonic anastomoses in rats three days after surgery.

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