Resumo Este artigo aborda a relação entre a obrigatoriedade de dispositivos de retenção (cadeirinhas) e as internações e mortes de crianças de zero a quatro anos em sinistros de trânsito no Brasil. A partir da obrigatoriedade do uso de dispositivos de retenção para crianças de até quatro anos pela legislação de trânsito brasileira, ocorrida no ano de 2010, os autores utilizam os dados do sistema DataSUS e do Denatran para analisar as séries temporais das internações e mortes de crianças de zero a quatro anos em sinistros de trânsito ocorridas no período de setembro de 2005 a agosto de 2015. São realizados dois recortes. Primeiro, uma análise do período compreendido entre os anos de 2005 e 2015, posteriormente esse período foi dividido em duas amostras, antes e depois da obrigatoriedade. Os resultados em ambos os recortes sugerem que a exigência da utilização dos dispositivos de retenção gerou redução de internações e mortes de crianças por sinistros de trânsito na faixa etária de zero a quatro anos, com prevalência da redução de internações sobre a de mortes.

Abstract The scope of this article is to address the relationship between mandatory restraint devices and hospitalizations and deaths of zero- to four-year-old age children in traffic accidents in Brazil. Based on the mandatory use of child restraint devices for children up to 4 years of age under Brazilian traffic legislation in 2010, the authors apply data from the DataSUS and Denatran databases to analyze the time series of hospitalizations and deaths of zero- to four-year-old age children in traffic accidents between September 2005 and August 2015. Two cut-off sample periods were examined, the first consisting of an analysis from 2005 to 2015, which was subsequently subdivided into two samples, namely before and after the requirement. The results of both cut-off sample periods suggest that demands concerning the use of restraint devices led to decreased hospitalizations and deaths of children due to traffic accidents in the zero- to four-year-old age group, with a prevalence of decreased rates of hospitalization over deaths.

Resumo Este artigo aborda a relação entre a obrigatoriedade de dispositivos de retenção (cadeirinhas) e as internações e mortes de crianças de zero a quatro anos em sinistros de trânsito no Brasil. A partir da obrigatoriedade do uso de dispositivos de retenção para crianças de até quatro anos pela legislação de trânsito brasileira, ocorrida no ano de 2010, os autores utilizam os dados do sistema DataSUS e do Denatran para analisar as séries temporais das internações e mortes de crianças de zero a quatro anos em sinistros de trânsito ocorridas no período de setembro de 2005 a agosto de 2015. São realizados dois recortes. Primeiro, uma análise do período compreendido entre os anos de 2005 e 2015, posteriormente esse período foi dividido em duas amostras, antes e depois da obrigatoriedade. Os resultados em ambos os recortes sugerem que a exigência da utilização dos dispositivos de retenção gerou redução de internações e mortes de crianças por sinistros de trânsito na faixa etária de zero a quatro anos, com prevalência da redução de internações sobre a de mortes.

Abstract The scope of this article is to address the relationship between mandatory restraint devices and hospitalizations and deaths of zero- to four-year-old age children in traffic accidents in Brazil. Based on the mandatory use of child restraint devices for children up to 4 years of age under Brazilian traffic legislation in 2010, the authors apply data from the DataSUS and Denatran databases to analyze the time series of hospitalizations and deaths of zero- to four-year-old age children in traffic accidents between September 2005 and August 2015. Two cut-off sample periods were examined, the first consisting of an analysis from 2005 to 2015, which was subsequently subdivided into two samples, namely before and after the requirement. The results of both cut-off sample periods suggest that demands concerning the use of restraint devices led to decreased hospitalizations and deaths of children due to traffic accidents in the zero- to four-year-old age group, with a prevalence of decreased rates of hospitalization over deaths.

ABSTRACT PURPOSE: To analyze the influence of chlorpromazine on renal histology of rats submitted to ischemia and reperfusion injury. METHODS: Sixteen Wistar rats - split in two groups - have been used: control group, receiving 3 mg/kg isotonic saline solution through caudal vein, and, the chlorpromazine group, receiving 3 mg/kg-IV of such medication. The nephrectomy of the left kidney lower third was carried out; immediately, the test-drug was administrated. After 15 minutes of test-drug administration, the renal pedicle was clamped; in 60 minutes of ischemia it was released. After 24 hours of the renal reperfusion, the rats were, once more, anesthetized and submitted to total left nephrectomy, and, afterwards, to euthanasia. Histological findings regarding ischemia have been evaluated and compared between the groups. RESULTS: There was no statistical difference related to inferior renal pole histological analysis. Regarding 60-minute renal ischemia, chlorpromazine has statistically reduced the accrual of leucocytes within the vasa recta renis (p=0.036) and the congestion of peritubular capillaries (p=0.041). When conducting joint analysis of histological patterns, the control group showed a median score of 11 and chlorpromazine group of 5.5 (p=0.036). CONCLUSION: Chlorpromazine significantly reduced the occurrence of secondary damage to ischemia and reperfusion process in the overall histological analysis.

Biscationic amidines bind in the DNA minor groove and present biological activity against a range of infectious diseases. Two new biscationic compounds (bis-α,ω-S-thioureido, amino and sulfide analogues) were synthesized in good yields and fully characterized, and their interaction with DNA was also investigated. Isothermal titration calorimetry (ITC) was used to measure the thermodynamic properties of binding interactions between DNA and these ligands. A double stranded calf thymus DNA immobilized on an electrode surface was used to study the possible DNA-interacting abilities of these compounds towards dsDNA in situ. A remarkable interaction of these compounds with DNA was demonstrated and their potential application as anticancer agents was furthered.