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Resumo Toxoplasma gondii e Neospora caninum são dois protozoários intimamente relacionados que infectam uma ampla gama de animais, incluindo-se aves. Entretanto, a ocorrência de N. caninum e T. gondii em aves marinhas é desconhecida. Portanto, este estudo objetivou determinar a presença de DNA de T. gondii e N. caninum em amostras de tecidos, coletadas de 47 aves marinhas. Amostras de tecidos dos músculos peitorais, coração e cérebro foram coletadas de 47 aves marinhas mortas ao longo da costa do estado de Santa Catarina, SC, Brasil. O DNA foi extraído dos tecidos e testado, usando-se a reação em cadeia da polimerase nested (nPCR), tendo em vista o espaçador interno transcrito 1 (ITS1). O DNA de T. gondii foi detectado em tecidos de sete aves marinhas (7/47, 14,8%), como gaivota (Larus dominicanus) (5/21) e bobo-pequeno (Puffinus puffinus) (2/8). O DNA de N. caninum foi detectado em tecidos de nove aves marinhas (9/47, 19,1%); gaivota (L. dominicanus) (4/21), bobo-pequeno (P. puffinus) (2/8), corvo-marinho (Phalacrocorax brasilianus) 1/4), atobá-pardo (Sula leucogaster) (1/5), e pardela-preta (Procellaria aequinoctialis) (1/1). No entanto, não foi observada coinfecção. Em conclusão, este estudo demonstrou a circulação de N. caninum e T. gondii em aves marinhas ao longo da costa de Santa Catarina, Brasil. Mais estudos são necessários para esclarecer o papel dessas aves na epidemiologia da neosporose e da toxoplasmose. animais incluindose incluindo se Entretanto N T desconhecida Portanto 4 peitorais Catarina SC Brasil testado usandose usando nPCR, nPCR , (nPCR) ITS1. ITS1 ITS . (ITS1) 7/47, 747 7 (7/47 14,8%, 148 14,8% 14 8 14,8%) Larus dominicanus 5/21 521 5 21 (5/21 bobopequeno bobo pequeno Puffinus puffinus 2/8. 28 2/8 2 (2/8) 9/47, 947 9 (9/47 19,1% 191 19 19,1%) L. L (L 4/21, 421 4/21 (4/21) P. P (P 2/8, corvomarinho corvo marinho Phalacrocorax brasilianus 1/4, 1/4 1/4) atobápardo atobá pardo Sula leucogaster 1/5, 15 1/5 (1/5) pardelapreta pardela preta Procellaria aequinoctialis 1/1. 11 1/1 (1/1) entanto coinfecção conclusão toxoplasmose (nPCR (ITS1 7/47 74 (7/4 14,8 5/2 52 (5/2 2/ (2/8 9/47 94 (9/4 19,1 42 4/2 (4/21 1/ (1/5 (1/1 (ITS 7/4 (7/ 14, 5/ (5/ (2/ 9/4 (9/ 19, 4/ (4/2 (1/ 7/ (7 (5 (2 9/ (9 (4/ (1 ( (4

Abstract Toxoplasma gondii and Neospora caninum are two closely related protozoans that infect a wide range of animals, including birds. However, the occurrence of N. caninum and T. gondii in seabirds is unknown. Therefore, this study aimed to determine the presence of T. gondii and N. caninum DNA in tissue samples of seabirds. Tissue samples of the pectoral muscles, heart, and brain were collected from 47 birds along the coastline of Santa Catarina State, SC, Brazil. The DNA was extracted from the tissues and screened using nested-PCR (nPCR) targeting internal transcribed spacer 1 (ITS1). T. gondii DNA was detected in tissues from seven seabirds (7/47, 14.8%), kelp gull (Larus dominicanus) (5/21), and Manx shearwater (Puffinus puffinus) (2/8). N. caninum DNA was detected in tissues of nine seabirds (9/47, 19.1%), the kelp gull (L. dominicanus) (4/21), Manx shearwater (P. puffinus) (2/8), neotropic cormorant (Phalacrocorax brasilianus) (1/4), brown booby (Sula leucogaster) (1/5), and white-chinned petrel (Procellaria aequinoctialis) (1/1); however, no co-infection was observed. In conclusion, this study showed the circulation of N. caninum and T. gondii in seabirds along the coastline of Santa Catarina State. Further studies are required to clarify the role of these birds in the epidemiology of neosporosis and toxoplasmosis. animals However N T unknown Therefore muscles heart 4 State SC Brazil nestedPCR nested PCR nPCR (nPCR ITS1. ITS1 ITS . (ITS1) 7/47, 747 7 (7/47 14.8%, 148 14.8% , 14 8 14.8%) Larus dominicanus 5/21, 521 5/21 5 21 (5/21) Puffinus puffinus 2/8. 28 2/8 2 (2/8) 9/47, 947 9 (9/47 19.1%, 191 19.1% 19 19.1%) L. L (L 4/21, 421 4/21 (4/21) P. P (P 2/8, Phalacrocorax brasilianus 1/4, 1/4 (1/4) Sula leucogaster 1/5, 15 1/5 (1/5) whitechinned white chinned Procellaria aequinoctialis 1/1 11 (1/1) however coinfection co infection observed conclusion toxoplasmosis (ITS1 7/47 74 (7/4 14.8 52 5/2 (5/21 2/ (2/8 9/47 94 (9/4 19.1 42 4/2 (4/21 1/ (1/4 (1/5 (1/1 (ITS 7/4 (7/ 14. 5/ (5/2 (2/ 9/4 (9/ 19. 4/ (4/2 (1/ 7/ (7 (5/ (2 9/ (9 (4/ (1 ( (5 (4

https://doi.org/10.1590/s1984-29612024019

Vaccination coverage, delay and loss to follow-up of the triple viral vaccine, in live births between 2017 and 2018 in Brazilian cities coverage followup follow up vaccine 201 20 2
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D’Agostini, Tatiana Lang

; Zambom, Fernanda Florencia Fregnan

; Moraes, José Cássio de

; França, Ana Paula

; Camargo, Jéssica Pires de

; Ribeiro, Manoel Carlos Sampaio de Almeida

; Barata, Rita Barradas

; Silva, Adriana Ilha da

; Ramos Jr., Alberto Novaes

; França, Ana Paula

; Oliveira, Andrea de Nazaré Marvão

; Boing, Antonio Fernando

; Domingues, Carla Magda Allan Santos

; Oliveira, Consuelo Silva de

; Maciel, Ethel Leonor Noia

; Guibu, Ione Aquemi

; Mirabal, Isabelle Ribeiro Barbosa

; Barbosa, Jaqueline Caracas

; Lima, Jaqueline Costa

; Moraes, José Cássio de

; Luhm, Karin Regina

; Caetano, Karlla Antonieta Amorim

; Lima, Luisa Helena de Oliveira

; Antunes, Maria Bernadete de Cerqueira

; Teixeira, Maria da Gloria

; Teixeira, Maria Denise de Castro

; Borges, Maria Fernanda de Sousa Oliveira

; Queiroz, Rejane Christine de Sousa

; Gurgel, Ricardo Queiroz

; Barata, Rita Barradas

; Azevedo, Roberta Nogueira Calandrini de

; Oliveira, Sandra Maria do Valle Leone de

; Teles, Sheila Araújo

; Gama, Silvana Granado Nogueira da

; Mengue, Sotero Serrate

; Simões, Taynãna César

; Nascimento, Valdir

; Araújo, Wildo Navegantes de

Epidemiologia e Serviços de Saúde

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2024, Volume 33 N. spe2 elocation e20231218

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

RESUMO Objetivo Estimar cobertura vacinal, atraso e perda de seguimento da vacina tríplice viral, em crianças até 24 meses residentes em cidades brasileiras. Método Inquérito domiciliar baseado em uma coorte retrospectiva de nascidos vivos em 2017-2018, que analisou cobertura e dados sociodemográficos das crianças e famílias, a partir dos registros da caderneta de vacinação e entrevista. Resultados A cobertura válida da primeira dose foi de 90,0% (IC95% 88,9;91,0), e da segunda, e 81,1% (IC95% 79,8;82,4). O atraso para ambas as doses foi de 23,2% (IC95% 21,9;24,5) e a perda de seguimento de 10,8% (IC95% 9,9;11,8). O estrato socioeconômico A apresentou menor cobertura e, à medida que a ordem de nascimento aumentava, menor era a cobertura para as duas doses. Crianças de mães com 13 a 15 anos de escolaridade apresentaram maior cobertura. Conclusão As coberturas não alcançaram a meta preconizada. Estratégias diferenciadas para dirimir dificuldade de acesso, desinformação e hesitação poderão melhorar a cobertura. vacinal viral 2 brasileiras 20172018, 20172018 2017 2018, 2018 2017-2018 famílias entrevista 900 90 0 90,0 IC95% IC95 IC (IC95 88,991,0, 889910 88,9 91,0 , 88 9 91 88,9;91,0) segunda 811 81 1 81,1 79,882,4. 798824 79,8 82,4 . 79 8 82 4 79,8;82,4) 232 23 23,2 21,924,5 219245 21,9 24,5 21 5 21,9;24,5 108 10 10,8 9,911,8. 99118 9,9 11,8 11 9,9;11,8) aumentava preconizada acesso 2017201 201 2017-201 90, IC9 (IC9 991 88,991,0 88991 889 88, 910 91, 88,9;91,0 81, 882 79,882,4 79882 798 79, 824 82, 7 79,8;82,4 23, 924 21,924, 21924 219 21, 245 24, 21,9;24, 10, 911 9,911,8 9911 99 9, 118 11, 9,9;11,8 201720 20 2017-20 (IC 88,991, 8899 88,9;91, 79,882, 7988 79,8;82, 92 21,924 2192 21,9;24 9,911, 9,9;11, 20172 2017-2 88,991 88,9;91 79,882 79,8;82 21,92 21,9;2 9,911 9,9;11 2017- 88,99 88,9;9 79,88 79,8;8 21,9; 9,91 9,9;1 88,9; 79,8; 9,9;

ABSTRACT Objective To estimate measles-mumps-rubella vaccination coverage, delay and loss to follow-up in children up to 24 months old living in Brazilian cities. Methods Surveys and questionnaires with a retrospective cohort of live births in 2017-2018, analyzing vaccination coverage and sociodemographic data of children and families, based on vaccination card records and interviews. Results Valid coverage of first dose was 90.0% (95%CI 88.9;91.0) and 81.1% for the second dose (95%CI 79.8;82.4). Delay for both doses was 23.2% (95%CI 21.9;24.5) and loss to follow-up was 10.8% (95%CI 9.9;11.8). Socioeconomic stratum A had the lowest vaccination coverage and the higher the child’s birth order, the lower the vaccination coverage for the second dose. Children whose mothers had 13 to 15 years of education had higher vaccination coverage. Conclusion Coverage did not meet the recommended target. Differentiated strategies to resolve difficulties in access, misinformation, and vaccination hesitancy will help improve vaccination coverage. measlesmumpsrubella measles mumps rubella followup follow 2 cities 20172018, 20172018 2017 2018, 2018 2017-2018 families interviews 900 90 0 90.0 95%CI 95CI CI 95 88.991.0 889910 88.9 91.0 88 9 91 88.9;91.0 811 81 1 81.1 79.882.4. 798824 79.8 82.4 . 79 8 82 4 79.8;82.4) 232 23 23.2 21.924.5 219245 21.9 24.5 21 5 21.9;24.5 108 10 10.8 9.911.8. 99118 9.9 11.8 11 9.9;11.8) childs child s order target access misinformation 2017201 201 2017-201 90. 991 88.991. 88991 889 88. 910 91. 88.9;91. 81. 882 79.882.4 79882 798 79. 824 82. 7 79.8;82.4 23. 924 21.924. 21924 219 21. 245 24. 21.9;24. 10. 911 9.911.8 9911 99 9. 118 11. 9.9;11.8 201720 20 2017-20 88.991 8899 88.9;91 79.882. 7988 79.8;82. 92 21.924 2192 21.9;24 9.911. 9.9;11. 20172 2017-2 88.99 88.9;9 79.882 79.8;82 21.92 21.9;2 9.911 9.9;11 2017- 88.9; 79.88 79.8;8 21.9; 9.91 9.9;1 79.8; 9.9;

resumen está disponible en el texto completo

https://doi.org/10.1590/s2237-96222024v33e20231218.especial2.en

Brazilian Thoracic Society recommendations for the diagnosis and monitoring of asbestos-exposed individuals asbestosexposed asbestos exposed
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Santos, Ubiratan Paula

; Algranti, Eduardo

; Capitani, Eduardo Mello De

; Prado, Gustavo Faibischew

; Carneiro, Ana Paula Scalia

; Rodrigues, Sílvia Carla Sousa

; Freitas, Jefferson Benedito Pires de

; Chate, Rodrigo Caruso

; Mizutani, Rafael Futoshi

; Castro, Hermano Albuquerque de

; Arbex, Marcos Abdo

; Ribeiro, Patrícia Canto

; Tietboehl Filho, Carlos Nunes

; Castellano, Maria Vera Cruz de Oliveira

; Leite, Guilherme Ward

; Almeida, Gustavo Corrêa de

Jornal Brasileiro de Pneumologia

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2024, Volume 50 N. 3 elocation e20240156

Abstract: En | Text: En | PDF: En

ABSTRACT Asbestos was largely used in Brazil. It is a mineral that induces pleural and pulmonary fibrosis, and it is a potent carcinogen. Our objective was to develop recommendations for the performance of adequate imaging tests for screening asbestos-related diseases. We searched peer-reviewed publications, national and international technical documents, and specialists’ opinions on the theme. Based on that, the major recommendations are: Individuals exposed to asbestos at the workplace for ≥ 1 year or those with a history of environmental exposure for at least 5 years, all of those with a latency period > 20 years from the date of initial exposure, should initially undego HRCT of the chest for investigation. Individuals with pleural disease and/or asbestosis should be considered for regular lung cancer monitoring. Risk calculators should be adopted for lung cancer screening, with a risk estimate of 1.5%. Brazil fibrosis carcinogen asbestosrelated related diseases peerreviewed peer reviewed publications documents specialists theme are 2 investigation andor monitoring 15 1.5% 1.5 1.

https://doi.org/10.36416/1806-3756/e20240156

Randomized trial of dentists’ understanding: treatment benefit in absolute numbers vs relative risk reduction dentists understanding
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NADANOVSKY, Paulo

; OLIVEIRA, Branca Heloisa de

; LIRA-JUNIOR, Ronaldo

; SANTOS, Ana Paula Pires dos

Brazilian Oral Research

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2024, Volume 38 elocation e070

Abstract: En | Text: En | PDF: En

Abstract This study aimed to assess whether dentists correctly understand the benefit of a dental treatment when it is presented using absolute numbers or relative risk reduction (RRR). This parallel-group randomized controlled trial recruited dentists from 3 postgraduate courses in Rio de Janeiro, Brazil. Participants received, in sequentially numbered sealed opaque envelopes, the description of a hypothetical scenario of the benefit (avoidance of multiple tooth loss) of nonsurgical periodontal treatment without or with antibiotics. Treatment benefit was presented in 2 different formats: absolute numbers or RRR. Dentists were given 10 minutes to read the treatment scenario and answer 5 questions. The final sample for analysis included 101 dentists. When asked to estimate the number of patients out of 100 who would avoid multiple tooth loss without antibiotics, 17 dentists (33%) in the absolute numbers group and 12 (25%) in the RRR group provided the correct response (p = 0.39). Regarding treatment with antibiotics, 26 dentists (50%) in the absolute numbers group and 14 (29%) in the RRR group provided the correct response (p = 0.04). Only 16 dentists (31%) in the absolute numbers group and 12 (25%) in the RRR group gave correct answers for both questions (p = 0.51). Most dentists did not correctly understand the benefit of the treatment, irrespective of the format it was presented. Slightly more dentists correctly understood the benefit of the treatment when it was presented as absolute numbers than as RRR. . (RRR) parallelgroup parallel Janeiro Brazil received envelopes avoidance antibiotics formats 1 33% 33 (33% 25% 25 (25% p 0.39. 039 0.39 0 39 0.39) 50% 50 (50% 29% 29 (29% 0.04. 004 0.04 04 0.04) 31% 31 (31% 0.51. 051 0.51 51 0.51) (RRR (33 (25 03 0.3 (50 (29 00 0.0 (31 05 0.5 (3 (2 0. (5 (

https://doi.org/10.1590/1807-3107bor-2024.vol38.0070

Inhaled nitric oxide in moderate-to-severe COVID-19 acute respiratory distress syndrome: a retrospective cohort study moderatetosevere moderate to severe COVID19 COVID 19 COVID-1 syndrome COVID1 1 COVID-
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Santos, Lucas Eduardo Benthien

; Padovese, Camila Campos Grisa

; Castro, Isabela Belarmino Oliveira de

; Franco, Rodrigo Carneiro

; Okuda, Ana Paula Pires Bolsoni

; Bustamante, Mariana Resende

; Gioli-Pereira, Luciana

einstein (São Paulo)

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2024, Volume 22 elocation eAO0578

Abstract: En | Text: En | PDF: En

ABSTRACT Objective To evaluate the responsiveness of COVID-19 acute respiratory distress syndrome patients to inhaled nitric oxide as part of their standard therapy. Methods This retrospective cohort study included critically ill adult patients with confirmed COVID-19 treated between March 2020 and May 2021. Eligible patients with moderate-to-severe acute respiratory distress syndrome due to COVID-19 were subsequently categorized into two groups based on inhaled nitric oxide use throughout their stay in the intensive care unit. The primary endpoints were overall mortality and improvement in oxygenation parameters 6 hours after inhaled nitric oxide use. Results A total of 481 patients admitted to the intensive care unit due to COVID-19 acute respiratory distress syndrome were screened, 105 of which were included. Among the 105 patients, inhaled nitric oxide therapy was used in 33 patients, will 72 did not undergo inhaled nitric oxide therapy. No significant difference in mortality was observed between the groups (67% for the treatment and 82% for the no-treatment groups respectively, p=0.173). Among the patients who used inhaled nitric oxide, 17 (51%) were considered responsive to therapy. There was no significant difference in the length of stay in the intensive care unit (p=0.324) or total hospitalization time (p=0.344). Conclusion Inhaled nitric oxide rescue therapy improved oxygenation in patients with COVID-19 with moderate-to-severe acute respiratory distress syndrome but did not affect mortality. COVID19 COVID 19 COVID-1 202 2021 moderatetosevere moderate severe 48 screened 10 3 7 67% 67 (67 82 notreatment respectively p=0.173. p0173 p p=0.173 . 0 173 p=0.173) 1 51% 51 (51% p=0.324 p0324 324 (p=0.324 p=0.344. p0344 p=0.344 344 (p=0.344) COVID1 COVID- 20 4 (6 8 p017 p=0.17 5 (51 p=0.32 p032 32 (p=0.32 p034 p=0.34 34 (p=0.344 2 ( p01 p=0.1 (5 p=0.3 p03 (p=0.3 (p=0.34 p0 p=0. (p=0. p=0 (p=0 p= (p= (p

https://doi.org/10.31744/einstein_journal/2024ao0578

The II Brazilian Guidelines for the pharmacological treatment of patients hospitalized with COVID-19 Joint Guidelines of the Associação Brasileira de Medicina de Emergência, Associação de Medicina Intensiva Brasileira, Associação Médica Brasileira, Sociedade Brasileira de Angiologia e Cirurgia Vascular, Sociedade Brasileira de Infectologia, Sociedade Brasileira de Pneumologia e Tisiologia and Sociedade Brasileira de Reumatologia COVID19 COVID 19 COVID-1 Emergência Vascular Infectologia COVID1 1 COVID-
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Falavigna, Maicon

; Araujo, Cintia Laura Pereira de

; Barbosa, Alexandre Naime

; Belli, Karlyse Claudino

; Colpani, Verônica

; Dal-Pizzol, Felipe

; Silva, Rosemeri Maurici da

; Azevedo, Luciano César Pontes de

; Dias, Maria Beatriz Souza

; Amaral, José Luiz Gomes do

; Dorneles, Gilson Pires

; Ferreira, Juliana Carvalho

; Freitas, Ana Paula da Rocha

; Gräf, Débora Dalmas

; Guimarães, Hélio Penna

; Lobo, Suzana Margareth Ajeje

; Machado, Flávia Ribeiro

; Nunes, Michelle Silva

; Oliveira, Maura Salaroli de

; Parahiba, Suena Medeiros

; Rosa, Regis Goulart

; Santos, Vania Cristina Canuto

; Sobreira, Marcone Lima

; Veiga, Viviane Cordeiro

; Xavier, Ricardo Machado

; Zavascki, Alexandre Prehn

; Stein, Cinara

; Carvalho, Carlos Roberto Ribeiro de

Critical Care Science

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sep 2023, Volume 35 N. 3 Pages 243 - 255

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Objetivo: Atualizar as recomendações para embasar as decisões para o tratamento farmacológico de pacientes hospitalizados com COVID-19 no Brasil. Métodos: A elaboração desta diretriz foi feita por especialistas, incluindo representantes do Ministério da Saúde e metodologistas. O método utilizado para o desenvolvimento rápido de diretrizes baseou-se na adoção e/ou adaptação de diretrizes internacionais existentes (GRADE ADOLOPMENT) e contou com o apoio da plataforma e-COVID-19 RecMap. A qualidade das evidências e a elaboração das recomendações seguiram o método GRADE. Resultados: Chegaram-se a 21 recomendações, incluindo recomendações fortes quanto ao uso de corticosteroides em pacientes em uso de oxigênio suplementar e recomendações condicionais para o uso de tocilizumabe e baricitinibe, em pacientes com oxigênio suplementar ou ventilação não invasiva, e de anticoagulantes, para prevenção de tromboembolismo. Devido à suspensão da autorização de uso, não foi possível fazer recomendações para o tratamento com casirivimabe + imdevimabe. Foram feitas recomendações fortes contra o uso de azitromicina em pacientes sem suspeita de infecção bacteriana, hidroxicloroquina, plasma convalescente, colchicina e lopinavir + ritonavir, além de recomendações condicionais contra o uso de ivermectina e rendesivir. Conclusão: Foram criadas novas recomendações para o tratamento de pacientes hospitalizados com COVID-19, como as recomendações de tocilizumabe e baricitinibe. Ainda são recomendados corticosteroides e profilaxia contra tromboembolismo, esta em caráter condicional. Vários medicamentos foram considerados ineficazes e não devem ser usados, no intuito de proporcionar o melhor tratamento segundo os princípios da medicina baseada em evidências e promover a economia de recursos. Objetivo COVID19 COVID 19 COVID-1 Brasil Métodos especialistas metodologistas baseouse baseou se eou GRADE ADOLOPMENT eCOVID19 eCOVID e-COVID-1 RecMap Resultados Chegaramse Chegaram 2 baricitinibe invasiva anticoagulantes tromboembolismo imdevimabe bacteriana hidroxicloroquina convalescente ritonavir rendesivir Conclusão COVID19, 19, condicional usados recursos COVID1 1 COVID- eCOVID1 e-COVID- e-COVID

ABSTRACT Objective: To update the recommendations to support decisions regarding the pharmacological treatment of patients hospitalized with COVID-19 in Brazil. Methods: Experts, including representatives of the Ministry of Health and methodologists, created this guideline. The method used for the rapid development of guidelines was based on the adoption and/or adaptation of existing international guidelines (GRADE ADOLOPMENT) and supported by the e-COVID-19 RecMap platform. The quality of the evidence and the preparation of the recommendations followed the GRADE method. Results: Twenty-one recommendations were generated, including strong recommendations for the use of corticosteroids in patients using supplemental oxygen and conditional recommendations for the use of tocilizumab and baricitinib for patients on supplemental oxygen or on noninvasive ventilation and anticoagulants to prevent thromboembolism. Due to suspension of use authorization, it was not possible to make recommendations regarding the use of casirivimab + imdevimab. Strong recommendations against the use of azithromycin in patients without suspected bacterial infection, hydroxychloroquine, convalescent plasma, colchicine, and lopinavir + ritonavir and conditional recommendations against the use of ivermectin and remdesivir were made. Conclusion: New recommendations for the treatment of hospitalized patients with COVID-19 were generated, such as those for tocilizumab and baricitinib. Corticosteroids and prophylaxis for thromboembolism are still recommended, the latter with conditional recommendation. Several drugs were considered ineffective and should not be used to provide the best treatment according to the principles of evidence-based medicine and to promote resource economy. Objective COVID19 COVID 19 COVID-1 Brazil Methods Experts methodologists guideline andor ADOLOPMENT eCOVID19 eCOVID e e-COVID-1 platform Results Twentyone Twenty one generated authorization imdevimab infection hydroxychloroquine plasma colchicine made Conclusion recommended recommendation evidencebased economy COVID1 1 COVID- eCOVID1 e-COVID- e-COVID

https://doi.org/10.5935/2965-2774.20230136-en

Factors associated with hospitalizations for Covid-19 in patients with rheumatoid arthritis: data from the Reumacov Brazil registry
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Gomides, Ana Paula Monteiro

; Albuquerque, Cleandro Pires de

; Mota, Licia Maria Henrique da

; Devidé, Guilherme

; Dias, Laiza Hombre

; Duarte, Angela Luzia Branco Pinto

; Giovelli, Raquel Altoé

; Karnopp, Thais Evelyn

; Lima, Hugo Deleon de

; Marinho, Adriana

; Oliveira, Marianne Schrader de

; Omura, Felipe

; Ranzolin, Aline

; Resende, Gustavo

; Ribeiro, Francinne Machado

; Ribeiro, Sandra Lúcia Euzébio

; Sacilotto, Nathália de Carvalho

; Santos, Wander Gonzaga dos

; Shinjo, Samuel Katsuyuki

; Studart, Samia Araujo de Sousa

; Teixeira, Flávia Patricia Sena

; Yazbek, Michel Alexandre

; Ferreira, Gilda Aparecida

; Monticielo, Odirlei A.

; Paiva, Eduardo

; Pileggi, Gecilmara Cristina Salviato

; Reis Neto, Edgard Torres dos

; Pinheiro, Marcelo de Medeiros

; Marques, Claudia D. L.

Advances in Rheumatology

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2022, Volume 62 elocation 13

Abstract: En | Text: En | PDF: En

Abstract Background: Patients using immunosuppressive drugs may have unfavorable results after infections. However, there is a lack of information regarding COVID 19 in these patients, especially in patients with rheumatoid arthritis (RA). Therefore, the aim of this study was to evaluate the risk factors associated with COVID 19 hospitalizations in patients with RA. Methods: This multicenter, prospective cohort study is within the ReumaCoV Brazil registry and included 489 patients with RA. In this context, 269 patients who tested positive for COVID 19 were compared to 220 patients who tested negative for COVID 19 (control group). All patient data were collected from the Research Electronic Data Capture database. Results: The participants were predominantly female (90.6%) with a mean age of 53 ±12 years. Of the patients with COVID 19, 54 (20.1%) required hospitalization. After multiple adjustments, the final regression model showed that heart disease (OR =4.61, 95% CI 1.06–20.02. P < 0.001) and current use of glucocorticoids (OR =20.66, 95% CI 3.09–138. P < 0.002) were the risk factors associated with hospitalization. In addition, anosmia was associated with a lower chance of hospitalization (OR =0.26; 95% CI 0.10–0.67, P < 0.005). Conclusion: Our results demonstrated that heart disease and the use of glucocorticoids were associated with a higher number of hospital admissions for COVID 19 in patients with RA. Trial registration: Brazilian Registry of Clinical Trials RBR 33YTQC.

https://doi.org/10.1186/s42358-022-00244-5

[SciELO Preprints] - CONCEPTS OF ENVIROMENTAL EDUCATION AND INFORMATION AND COMMUNICATION TECHNOLOGIES IN BIOLOGICAL SCIENCES TEACHER EDUCATION CURRICULUM
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Amancio, Andréia Pires Vieira, Darlene Ana de Paula Costa, Lorenna Silva Oliveira Costa, Renata Luiza da

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Publication date: 2021-12-13

Abstract: En Es Pt

Among several themes present in the Brazilian education curriculum, Information and Communication Technologies (ICT) and Environmental Education (EE) are focused in this article, as they are themes of profound relevance to contemporary society, which make them essential for appropriation by teachers. Thus, the aim of this article is to present results of documental research regarding the presence and conceptions that underlie initial teacher education syllabus. For this, two pedagogical projects of teacher education in Biological Sciences from public institutions in the State of Goiás were selected. Guided by historical-dialectical materialism, it was possible to see, in both documents, the concern to meet the requirements of national legislation regarding the two themes, in addition to the forecast of interdisciplinary projects regarding EE and the association of the quality of the educational process with the technical use of ICT, regardless of the pedagogical orientation. There was also a lack of clarity regarding the implementation of the cross-cutting and interdisciplinary approaches that were cited, and a result that is in line with previous research with a mostly instrumental design.

Entre varios temas presentes en el currículo educativo brasileño, las Tecnologías de la Información y la Comunicación (TIC) y la Educación Ambiental (EA) se centran en este artículo, ya que son temas de profunda relevancia para la sociedad contemporánea, que los hacen imprescindibles para la apropiación por parte de los docentes. Así, el objetivo de este artículo es presentar los resultados de una investigación documental sobre la presencia y concepciones que subyacen a los currículos de formación inicial docente. Para ello, se seleccionaron dos proyectos pedagógicos para educación del profesorado en Ciencias Biológicas de instituciones públicas del Estado de Goiás. Guiados por el materialismo histórico-dialéctico, se pudo ver, en ambos documentos, la preocupación por cumplir con los requisitos de la legislación nacional en materia de los dos temas, además de la previsión de proyectos interdisciplinarios en materia de EA y la asociación de la calidad del proceso educativo con el uso técnico de las TIC, independientemente de la orientación pedagógica. También hubo falta de claridad en la implementación de los enfoques transversales e interdisciplinarios que fueron citados, resultado que está en línea con investigaciones previas con un diseño mayoritariamente instrumental.

Dentre diversos temas presentes no currículo da educação brasileira, são focalizados neste artigo as Tecnologias da Informação e Comunicação (TIC) e a Educação Ambiental (EA), devido serem temas de profunda relevância para a sociedade contemporânea, o que os tornam de imprescindível apropriação pelos professores. Assim, o objetivo deste artigo é apresentar resultados de pesquisa documental a respeito da presença e das concepções que fundamentam os currículos de formação inicial de professores. Para isso, foram selecionados dois projetos pedagógicos de cursos de licenciatura em Ciências Biológicas de instituições públicas do Estado de Goiás. Orientados pelo materialismo histórico-dialético, foi possível perceber, em ambos os documentos, a preocupação em atender as exigências das legislações nacionais quanto aos dois temas, além da previsão de projetos interdisciplinares quanto à EA e a associação da qualidade do processo educativo ao uso técnico de TIC, independentemente da orientação pedagógica. Também identificou-se falta de clareza a respeito da implementação das abordagens transversal e interdisciplinar muito citadas e resultado consonante com as pesquisas anteriores de concepção, majoritariamente, instrumental.

https://doi.org/10.1590/SciELOPreprints.3199

Vacinação para influenza em idosos na pandemia COVID-19: estudo de base populacional em 133 cidades brasileiras
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Menezes, Ana Maria Baptista

; Hallal, Pedro Curi

; Silveira, Mariângela Freitas

; Wehrmeister, Fernando César

; Horta, Bernardo Lessa

; Barros, Aluísio Jardim Dornellas de

; Hartwig, Fernando Pires

; Oliveira, Paula Duarte

; Vidaletti, Luís Paulo

; Mesenburg, Marilia Arndt

; Jacques, Nadege

; Barros, Fernando C

; Victora, Cesar Gomes

Ciência & Saúde Coletiva

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aug 2021, Volume 26 N. 8 Pages 2937 - 2947

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Imunizações de rotina durante pandemias podem ser prejudicadas. Este estudo estimou a cobertura vacinal para influenza em idosos durante a COVID-19 através do EPICOVID-19, inquérito populacional realizado em 133 cidades sentinelas dos 26 estados brasileiros e Distrito Federal. Selecionou-se 25 setores censitários por cidade, amostragem proporcional ao tamanho, dez domicílios por setor e uma pessoa por domicílio, aleatoriamente. O quantitativo de 8.265 idosos (≥ 60 anos) foram entrevistados e responderam se haviam sido vacinados contra gripe em 2020. A cobertura foi 82,3% (IC95% 80,1; 84,2), sem diferenças por sexo, idade ou região. Maiores coberturas ocorreram nos mais ricos (84,7% versus 80,1% nos mais pobres) e nos mais escolarizados (87,3% versus 83,2% nos menos escolarizados). Menor cobertura nos indígenas (56,9% versus coberturas superiores a 80% nos demais grupos étnicos). Houve associação positiva com número de comorbidades entre homens, mas não entre mulheres. A maioria vacinou-se na rede pública (97,5%), sendo a rede privada mais utilizada na região Sul, pelos mais escolarizados e mais ricos. Conclui-se que a cobertura vacinal ficou sete pontos percentuais abaixo da meta governamental (90%), e que desigualdades devem ser revertidas em futuras campanhas.

Abstract Routine immunization during pandemics can be harmed. This study estimated the influenza vaccination coverage in older adults during the COVID-19 through the EPICOVID-19, a population-based study conducted in 133 cities from the 26 Brazilian states and Federal District. We selected 25 census tracts per city, with probability proportional to the tract’s size, ten households by census tract, and one random individual interviewed. A total of 8,265 older adults (≥60 years old) were interviewed and asked whether they had been vaccinated against flu in 2020. Vaccination coverage was 82.3% (95% CI: 80.1-84.2) with no difference by gender, age, and region; higher vaccination coverage was observed among the wealthiest (84.7% versus 80.1% in the poorest) and among the more educated (87.3% versus 83.2% less educated); lower coverage among indigenous (56.9% versus > 80% among other ethnic groups). A positive association was identified with the number of comorbidities among men but not among women. Most of the population was vaccinated (97.5%) in the public health system. The private network was chosen mainly in the South by the wealthiest and more educated. Vaccination coverage was seven percentage points lower than the government target (90%), and inequalities should be reversed in future campaigns.

https://doi.org/10.1590/1413-81232021268.09382021 2 downloads

10.

[SciELO Preprints] - Influenza vaccination in the elderly during the COVID-19 pandemic: A population-based study in 133 Brazilian cities
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Menezes, Ana Maria B Curi Hallal, Pedro Freitas Silveira, Mariângela C Wehrmeister, Fernando Lessa Horta, Bernardo Jardim Dornellas de Barros, Aluísio Pires Hartwig, Fernando Oliveira, Paula Vidaletti, Luís Paulo A Mesenburg, Marilia Jacques, Nadege C Barros, Fernando Gomes Victora, Cesar

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Publication date: 2021-02-08

Abstract: En Pt

Influenza vaccination coverage in the elderly was analysed during the COVID-19 pandemic through the EPICOVID-19, a population-based study conducted in 133 cities from the 26 Brazilian states and Federal District. Twenty five census tracts were sampled with probability proportional to the size of the tract, 10 households by census tracts and one random person interviewed. A total of 33,250 people were interviewed being 8,262  ≥60 years old. The elderly were asked whether they had had a flu vaccine in 2020. Vaccination coverage was 82.3% (CI95%=8 0.1-84.2) with no difference by sex, age, and region. Higher vaccination coverage was observed in the richest compared to the poorest (84.7% and 80.1%; p=<0.001), and among those with higher schooling (87.3% and 83.2; p=0.007). The indigenous presented lower coverage (56.9%) than other ethnic groups (>80%) (p=0.056). A positive association existed between vaccination coverage and number of comorbidities for men, but not for women. Most of those who were vaccinated (97.5%) received the vaccine in the public health system. The private was chosen mostly in the south, by the rich and by those with more schooling. Vaccination coverage was seven percentage points lower than the government target, and inequalities should be reverted in future campaigns.

Avaliou-se a cobertura vacinal para influenza em idosos na pandemia COVID-19 através do EPICOVID-19, inquérito de base populacional realizado em 133 cidades sentinela dos 26 estados brasileiros e Distrito Federal. Selecionou-se 25 setores censitários por cidade com amostragem proporcional ao tamanho, 10 domicílios por setor e uma pessoa por domicílio, aleatoriamente. Foram entrevistadas 33.250 pessoas, sendo 8.265 idosos. Perguntou-se aos idosos se haviam sido vacinados contra gripe em 2020. A cobertura foi de 82,3% (IC 95% 80,1–84,2), sem diferenças por sexo, idade ou região. Foram observadas maiores coberturas no quintil mais rico (84,7% contra  80,1% no mais pobre; p<0.001) e naqueles com graduação completa (87,3% contra 83,2% com fundamental incompleto; p=0.007), e menor cobertura nos indígenas (56,9% comparado a coberturas superiores a 80% nos demais grupos étnicos) (p=0,056). Houve associação positiva da cobertura com número de comorbidades entre homens, mas não entre mulheres. A maioria vacinou-se na rede pública (97,5%), sendo a rede privada mais utilizada na região sul, pelos mais escolarizados e mais ricos. Conclui-se que a cobertura vacinal ficou sete pontos percentuais abaixo da meta governamental, e que desigualdades devem ser revertidas em futuras campanhas.

https://doi.org/10.1590/SciELOPreprints.1797

11.

Vacinação para influenza em idosos na pandemia COVID-19: estudo de base populacional em 133 cidades brasileiras
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Menezes, Ana Maria Baptista

; Hallal, Pedro Curi

; Silveira, Mariângela Freitas

; Wehrmeister, Fernando César

; Horta, Bernardo Lessa

; Barros, Aluísio Jardim Dornellas de

; Hartwig, Fernando Pires

; Oliveira, Paula Duarte

; Vidaletti, Luís Paulo

; Mesenburg, Marilia Arndt

; Jacques, Nadege

; Barros, Fernando C

; Victora, Cesar Gomes

Ciência & Saúde Coletiva

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2021, Volume 26 N. 8 Pages 2937 - 2947

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.1590/1413-81232021268.09382021

12.

Changes in carbohydrates accumulation in Viguiera discolor Baker in response to water deficit
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Sanches, Rodrigo Fazani Esteves

; Silva, Ana Paula Oliveira da

; Costa, Vanessa Pires da

; Carvalho, Maria Ângela Machado de

; Silva, Emerson Alves da

Hoehnea

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2019, Volume 46 N. 4 elocation e382019

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO O estresse hídrico é um fator ambiental que pode regular o crescimento, limitando a produção e levando a alterações fisiológicas e bioquímicas. Plantas apresentam uma série de respostas adaptativas a seca, tal como ajustamento osmótico, nos quais os carboidratos desempenham um importante papel. Avaliamos a influência do déficit hídrico no acúmulo de carboidratos em V. discolor, nas quais foram divididas em dois grupos: rega diária e restrição de água por 14 dias sendo reidratadas após esse período. Folhas e raízes foram coletados nos tempos: 0, 3, 6, 9, 12, 15 e 18 dias após o início da restrição hídrica, para análises ecofisiológicas e bioquímicas. As variações nos teores de carboidratos em V. discolor mostrou uma estreita relação com alterações no estado da água da planta, com concentrações mais elevadas de açúcares solúveis totais, frutanos totais, oligossacáridos, açúcares redutores que coincidem com os menores índices de potenciais hídricos do solo e folhas, assim como menor teor relativo de água foliar. Nas raízes tuberosas, observa-se aumento nas concentrações de carboidratos após retorno das regas. O aumento desses carboidratos de baixo peso molecular está envolvido no ajuste osmótico e, consequentemente, atua na proteção contra a desidratação.

ABSTRACT Water stress is an environmental factor that can regulate growth, limit production and lead to physiological and biochemical changes. Plants present a series of adaptive responses to drought, such as osmotic adjustment, in which carbohydrates play an important role. To evaluate the influence of water deficit on carbohydrates accumulation in V. discolor, the plants were divided into two groups: daily watering and water suppression for 14 days being re-watering after this period. Leaves and roots were collected at 0, 3, 6, 9, 12, 15 and 18 days, for ecophysiological and biochemical analyzes. Variations in carbohydrate contents in V. discolor showed a close relationship with changes in the plant water status, with higher concentrations of soluble sugars, total fructans, oligosaccharides, reducing sugars coinciding with the lower values of soil moisture and leaf water potentials and relative water content. In the tuberous roots, there is an increase in carbohydrate concentrations after re-watering. The increase of these low molecular weight carbohydrates is involved in osmotic adjustment and therefore acts to protect against dehydration.

https://doi.org/10.1590/2236-8906-38/2019 860 downloads

13.

Isolation, morphological and molecular characterization of Bacillus thuringiensis strains against Hypothenemus hampei Ferrari (Coleoptera: Curculionidae: Scolytinae)
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Zorzetti, Janaina

; Ricietto, Ana Paula Scaramal

; Fazion, Fernanda Aparecida Pires

; Meneghin, Ana Maria

; Neves, Pedro Manuel Oliveira Janeiro

; Vilas-Boas, Laurival Antonio

; Vilas-Bôas, Gislayne Trindade

Revista Brasileira de Entomologia

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sep 2018, Volume 62 N. 3 Pages 198 - 204

Abstract: En | Text: En | PDF: En

ABSTRACT The coffee berry borer Hypothenemus hampei Ferrari, 1876 (Coleoptera: Curculionidae: Scolytinae) is considered the most serious pest of the coffee crop and is controlled primarily with the use of chemical insecticides. An alternative to this control method is the use of the entomopathogenic bacterium, Bacillus thuringiensis Berliner, 1911. Therefore, the objective of this work was to select strains of B. thuringiensis virulent against H. hampei and characterize them by morphological and molecular methods to identify possible genes for the production of genetically modified plants. To achieve this objective, 34 strains of B. thuringiensis underwent a selective bioassay to evaluate their toxicity to H. hampei first-instar larvae. Among the strains tested, 11 and the standard B. thuringiensis subspecies israelensis (IPS-82) caused mortality above 90%. Then, the median lethal concentration (LC50) was estimated for these strains followed by characterization using morphological, biochemical and molecular methods. The lowest LC50 was obtained for strain BR58, although this concentration did not differ significantly from that of the standard strain IPS-82 or from that of strains BR137, BR80 and BR67. The molecular characterization detected cry4A, cry4B, cry10, cry11 and cyt1 genes in 10 of the most virulent strains (BR58, BR137, BR80, BR81, BR147, BR135, BR146, BR138, BR139, BR140). Strain BR67 differed completely from the others and amplified only the cry3 gene. This strain was more virulent than BR135, BR146, BR138, BR139 and BR140, but it did not differ from BR58, BR137, BR80, BR81 and BR147. The protein profile revealed proteins of 28, 65, 70 and 130 kDa, and the morphological analysis identified spherical crystalline inclusions in all strains. The results showed that the 11 strains studied have potential for use as a gene source for insertion into coffee plants for the control H. hampei, especially the cry3, cry4A, cry4B, cry10, cry11 and cyt1 genes, that were repeated in the most virulent isolates.

https://doi.org/10.1016/j.rbe.2018.07.002 763 downloads

14.

Efecto del ataque de Leptocybe invasa en plantaciones de eucalipto destinadas a la producción de pulpa de celulosa kraft
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Bobadilha, Gabrielly dos Santos

; Vidaurre, Graziela Baptista

; Câmara, Ana Paula

; Valin, Marina

; Oliveira, José Tarcísio da Silva

; Soliman, Everton Pires

; Lopez, Yonny Martinez

Maderas. Ciencia y tecnología

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jun 2018, Volume 20 N. 2 Pages 171 - 182

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Abstract: The aim of the research was to evaluate the effect of the attack Leptocybe invasa in dendrometric variables and wood properties of two clones of eucalyptus (Eucalyptus urophylla and Eucalyptus tereticornis), grown in the municipalities of Imperatriz (state of Maranhão) and Darcinopolis (state of Tocantins), Brazil, for Kraft pulping. Data were collected 10 trees for each clone, the 3-year-old attacked by L. invasa. The diagnosed was based on formation of large guts all over the glass, and emergency hole (closing the loop). The results were confirmed by the variation of the characteristics of species assessed relative to their total height, diameter, volume of bark, vessel frequency, fiber size, radial density profile vessel frequency, fiber size, radial density profile, and ash content. Host trees obtained alterations in dendrometric variables, content of pentosans and wood ashes for both genetic materials, not being observed variations in specific gravity, and size of vessels and fibers, as well as the contents of lignin and wood extractives.

Resumen: El objetivo de la investigación fue evaluar el efecto del ataque de Leptocybe invasa en las propiedades dendrométricas de la madera de dos clones de eucalipto (Eucalyptus urophylla y Eucalyptus tereticornis), cultivados en los municipios de Imperatriz (Estado do Maranhão) y Darcinópolis (Estado de Tocantins), Brasil, destinados a la producción de pulpa kraft. Se analizaron 10 árboles de 3 años de edad atacados por Leptocybe invasa, para cada clon. El diagnóstico fue basado en la formación de grandes agallas en la copa, y con orificio de emergencia (cerrando el ciclo). Los resultados fueron constatados por la variación de las características de las especies evaluadas con relación a su altura total, diámetro, volumen de corteza, frecuencia de vasos, longitud de fibras, perfil radial de densidad y contenido de cenizas. Los árboles hospederos presentaron alteraciones en las variables dendrométricas, contenido de pentosanos y cenizas en la madera para ambos materiales genéticos, no siendo observadas variaciones en la densidad básica, dimensión de vasos y fibras, así como en los contenidos de lignina y extractivos de la madera.

629 downloads

15.

High-risk behaviors for hepatitis B and C infections among female sex workers
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Puga, Marco Antonio Moreira

; Bandeira, Larissa Melo

; Weis, Sabrina Moreira dos Santos

; Fernandes, Fernanda Rodas Pires

; Castro, Lisie Souza

; Tanaka, Tayana Serpa Ortiz

; Rezende, Grazielli Rocha de

; Teles, Sheila Araújo

; Castro, Vivianne de Oliveira Landgraf de

; Murat, Paula Guerra

; Capelin, Gina Jonasson Mousquer

; Motta-Castro, Ana Rita Coimbra

Revista da Sociedade Brasileira de Medicina Tropical

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apr 2018, Volume 51 N. 2 Pages 198 - 202

Abstract: En | Text: En | PDF: En

Abstract INTRODUCTION: The prevalence of hepatitis B and hepatitis C and risk behaviors among 402 female sex workers in Central Brazil were investigated by respondent-driven sampling. METHODS: Blood samples were tested for hepatitis B and C markers by enzyme-linked immunosorbent assay. Two hepatitis B vaccination schedules were performed. RESULTS: The prevalence of hepatitis B and C infections were 9.3% and 0.5%, respectively. Susceptibility to hepatitis B infection was observed in 61.5% of subjects. There was no significant difference in adherence index (p=0.52) between vaccination schedules and all participants had protective antibody titers. CONCLUSIONS: This hard-to-reach population requires hepatitis B and C surveillance.

https://doi.org/10.1590/0037-8682-0231-2017 1981 downloads

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