Resumo O propósito do presente artigo é propor uma metodologia para caracterização da (In)Sustentabilidade Financeira de municípios brasileiros − materializada por meio do Índice de Sustentabilidade Financeira Municipal (ISFM) − em contraponto à metodologia sugerida pela Proposta de Emenda à Constituição (PEC) no 188, que traz como pauta a incorporação de pequenos municípios considerados insustentáveis. Como métodos utilizou-se pesquisa quantitativa, aplicada, descritiva e explicativa, do tipo bibliográfica e documental, além de estatística descritiva e correlação/regressão linear. Os resultados demonstram que o ISFM possui maior robustez comparado à metodologia proposta pela PEC. O Índice foi aplicado aos 5.570 municípios brasileiros e a média nacional resultou em 56%. A maior parcela dos municípios brasileiros se classificou como “Sustentável” e as análises estatísticas demonstraram, significativamente, a existência de correlação positiva entre as variáveis ISFM e Desenvolvimento Local. As contribuições do trabalho se voltam para a produção de pesquisa sobre a temática, ainda incipiente nacionalmente. InSustentabilidade In (ISFM PEC (PEC 188 insustentáveis utilizouse utilizou quantitativa aplicada explicativa documental correlaçãoregressão regressão linear 5570 5 570 5.57 56 56% Sustentável “Sustentável demonstraram significativamente Local temática nacionalmente 18 557 57 5.5 1 55 5.

Résumé Le but de cet article est de proposer une méthodologie pour caractériser la (In)Durabilité Financière des municipalités brésiliennes - concrétisée par le biais de l’Indice de Durabilité Financière Municipale (ISFM) - en opposition à la méthodologie suggérée par la Proposition d’Amendement Constitutionnel (PEC) n° 188, qui vise à incorporer les petites municipalités considérées comme insoutenables. Les méthodes utilisées comprennent la recherche quantitative, appliquée, descriptive et explicative, de type bibliographique et documentaire, ainsi que la statistique descriptive et la corrélation/régression linéaire. Les résultats montrent que l’ISFM est plus robuste que la méthodologie proposée par la PEC. L’indice a été appliqué aux 5 570 municipalités brésiliennes et la moyenne nationale s’est élevée à 56%. La plupart des municipalités brésiliennes ont été classées comme “Durables” et les analyses statistiques ont démontré de manière significative l’existence d’une corrélation positive entre les variables ISFM et Développement Local. Les contributions de ce travail se concentrent sur la production de recherches sur le sujet, encore peu développé au niveau national. InDurabilité In lIndice l Indice (ISFM dAmendement d Amendement PEC (PEC n 188 insoutenables quantitative appliquée explicative documentaire corrélationrégression régression linéaire lISFM Lindice L indice 57 sest s 56 56% Durables “Durables lexistence existence dune Local sujet national 18 1

Abstract This article intends to propose a methodology to characterize the Financial (In)Sustainability of Brazilian municipalities − materialized through the Municipal Financial Sustainability Index (ISFM) − as opposed to the methodology suggested by the Proposed Amendment to the Constitution (PEC) No. 188, whose agenda is to incorporate small municipalities considered unsustainable. Regarding the methods, we used quantitative, applied, descriptive and explanatory research, of the bibliographical and documentary type, in addition to descriptive statistics and correlation/linear regression. The results demonstrate that the ISFM is more robust compared to the methodology proposed by the PEC. The Index was applied to 5,570 Brazilian municipalities and the national average resulted in 56%. Most Brazilian municipalities classified themselves as “Sustainable” and the statistical analysis significantly demonstrated the existence of a positive correlation between the variables ISFM and Local Development. The contributions of the work turn to the production of research on the subject, still incipient nationally. InSustainability In (ISFM PEC (PEC No 188 unsustainable methods quantitative type correlationlinear linear regression 5570 5 570 5,57 56 56% Sustainable “Sustainable Development subject nationally 18 557 57 5,5 1 55 5,

Resumen El objetivo de este artículo es proponer una metodología para caracterizar la (In)Sostenibilidad Financiera de los municipios brasileños - materializada a través del Índice de Sostenibilidad Financiera Municipal (ISFM) - en contraposición a la metodología sugerida por la Propuesta de Enmienda a la Constitución (PEC) no 188, que tiene como agenda la incorporación de pequeños municipios considerados insostenibles. Los métodos utilizados fueron cuantitativos, aplicados, descriptivos y explicativos, bibliográficos y documentales, así como la estadística descriptiva y la correlación/regresión lineal. Los resultados muestran que el ISFM es más robusto que la metodología propuesta por el PEC. El Índice se aplicó a 5.570 municipios brasileños y la media nacional fue del 56%. La mayoría de los municipios brasileños fueron clasificados como “Sostenibles” y los análisis estadísticos mostraron una correlación positiva significativa entre las variables ISFM y Desarrollo Local. Las aportaciones de este trabajo se dirigen a la producción de investigaciones sobre el tema, aún incipiente a nivel nacional. InSostenibilidad In (ISFM PEC (PEC 188 insostenibles cuantitativos aplicados explicativos documentales correlaciónregresión regresión lineal 5570 5 570 5.57 56 56% Sostenibles “Sostenibles Local tema 18 557 57 5.5 1 55 5.

Reconociendo los efectos penetrantes de las Nuevas Tecnologías de Información y Comunicación (NTICs) en todas las esferas de la contemporaneidad, este trabajo relata la experiencia y los dilemas de un grupo de reflexión sobre la siguiente pregunta: la utilización de tecnologías de modo masivo y penetrante en el cotidiano y consecuentemente, en la salud, ¿merece un concepto propio para un destaque analítico y sociopolítico? Por medio de la sistematización de Holliday, el grupo propone el concepto de Determinantes Digitales de la Salud (DDS) por la necesidad de poner en evidencia con fuerza la acción de la NTICs en la salud, tanto desde el punto de vista epistemológico, como del sociopolítico. Con la sugerencia del concepto de DDS, exhortamos a la comunidad académica para realizar un debate específico sobre las consecuencias de las NTICs en la existencia cotidiana para la orientación de acciones capaces de mitigar los efectos negativos y potenciar los beneficios de las nuevas tecnologías en la salud.

Reconhecendo os efeitos pervasivos das Novas Tecnologias de Informação e Comunicação (NTICs) em todas as esferas da contemporaneidade, este trabalho relata a experiência e os dilemas de um grupo de reflexão sobre a seguinte pergunta: A utilização de tecnologias de modo massivo e pervasivo no cotidiano e, consequentemente, na Saúde, merece conceito próprio para destaque analítico e sociopolítico? Por meio da sistematização de Holliday, o grupo propõe o conceito de Determinantes Digitais da Saúde (DDS) pela necessidade de evidenciar com força a ação das NTICs na Saúde — tanto do ponto de vista epistemológico quanto do sociopolítico. Com a sugestão do conceito de DDS, exortamos a comunidade acadêmica a um debate específico sobre as consequências das NTICs na existência cotidiana para a orientação de ações capazes de mitigar os efeitos negativos e potencializar os benefícios das novas tecnologias na Saúde.

Abstract By acknowledging the pervasive effects of New Information and Communication Technologies (NICTs) in contemporary life, this paper reports on the experience and dilemmas of a reflection group on the following question: does the overwhelming and pervasive use of technologies in everyday life, and consequently in health, deserve its own concept for analytical and socio-political prominence? Using Holliday’s systematization, the group proposed the concept of Digital Determinants of Health (DDH) due to the need to strongly highlight the action of NICTs in health - both from an epistemological and socio-political point of view. With the suggestion of the concept of DDH, we urge the academic community to engage in a specific debate on the consequences of NICTs in everyday life in order to guide actions capable of mitigating the negative effects and enhancing the benefits of new technologies in health.

Resumo Este estudo investigou o efeito da incorporação de cal dolomítica na microestrutura e nas propriedades mecânicas de geopolímeros à base de metacaulim ativados por solução alcalina. Foram preparadas cinco misturas de geopolímeros com adição de 0,0%, 2,5%, 5,0%, 7,5% e 10,0% de cal dolomítica. A microestrutura dos geopolímeros foi avaliada por microscopia eletrônica de varredura (MEV), espectroscopia de energia dispersiva de raios X (EDS) e análises de difração de raios X (DRX). A resistência à compressão das misturas variou entre 53,2 e 63,0 MPa após 28 dias de cura ambiente. As análises SEM/EDS mostraram que as principais fases formadas foram o gel N-A-S-H juntamente com os géis C-A-S-H e N-M-A-S-H nas misturas com cal dolomítica. Em resumo, os resultados mostraram que a incorporação de cal dolomítica pode melhorar significativamente a microestrutura e as propriedades dos geopolímeros. alcalina 00 0 0,0% 25 2 5 2,5% 50 5,0% 75 7 7,5 100 10 10,0 MEV, MEV , (MEV) EDS (EDS DRX. DRX . (DRX) 532 53 53, 630 63 63, ambiente SEMEDS SEM NASH N S H CASH C NMASH M resumo 0,0 2,5 5,0 7, 1 10, (MEV (DRX 6 0, 2, 5,

Abstract This study investigated the effect of dolomitic lime incorporation on the microstructure and mechanical properties of metakaolin-based geopolymers activated by alkaline solution. Five geopolymer mixtures were prepared with the addition of 0.0%, 2.5%, 5.0%, 7.5%, and 10.0% dolomitic lime. The microstructure of the geopolymers was evaluated by scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDS), and X-ray diffraction analyses (XRD). The compressive strength of the mixtures ranged between 53.2 and 63.0 MPa after 28 days of ambient curing. SEM/EDS analyses showed that the main phases formed were the N-A-S-H gel together with the C-A-S-H and N-M-A-S-H gels in the mixtures with dolomitic lime. In summary, the results showed that the incorporation of dolomitic lime can significantly improve the microstructure and properties of geopolymers. metakaolinbased metakaolin based solution 00 0 0.0% 25 2 5 2.5% 50 5.0% 75 7 7.5% 100 10 10.0 SEM, SEM , (SEM) energydispersive energy dispersive Xray X ray EDS, EDS (EDS) XRD. XRD . (XRD) 532 53 53. 630 63 63. curing SEMEDS NASH N A S H CASH C NMASH M summary 0.0 2.5 5.0 7.5 1 10. (SEM (EDS (XRD 6 0. 2. 5. 7.

Bisphenol A (BPA), an endocrine disruptor used in different commercial polymers, is a persistent pollutant commonly found in effluents. Conventional wastewater treatment processes have low chemical removal efficiency and are expensive. This work evaluated BPA removal using laccase enzyme produced from white rot fungus Pleurotus ostreatus. For the enzymatic production, residues of acai berry and pineapple were used as laccase inducers. The use of natural inducers led to a high enzyme production (1139 and 1031 U mL−1 to acai and pineapple, respectively). Bisphenol A was removed to a concentration lower than LOD (limit of detection) after 4 h. The degradation mechanism of BPA occurred by oxidation of methyl to hydroxymethyl group in a propane portion, with breakdown of the aromatic ring. The developed technology brought to the scene a new green, viable methodology, using vegetable waste, adding value to these residues and bringing an alternative to the BPA treatment. BPA, , (BPA) polymers effluents expensive ostreatus 1139 (113 103 mL1 mL 1 mL− respectively. respectively . respectively) limit detection h portion ring green methodology waste (BPA 113 (11 10 11 (1 (

This review provides an overview of the recent progress in organic electrosynthesis in Brazil, ranging from 2013 to 2023. By highlighting the principles, applications, and limitations of various electrosynthetic methodologies, this article aims to contribute to the understanding of basic principles and stimulate research in this field in Brazil. Moreover, the limitations and challenges associated with organic electrosynthesis are covered. Factors such as electrode material selection, solvent effects, and reaction optimization are discussed, highlighting the need for further research and development to overcome these obstacles. Finally, future prospects are outlined. Brazil 201 2023 applications methodologies Moreover covered selection effects discussed obstacles Finally outlined 20 202 2

RESUMO: Os casos de abdome agudo estão entre as doenças mais prevalentes e desafiadoras na medicina equina. O diagnóstico inclui a realização de anamnese e avaliação clínica detalhada do paciente, permitindo a coleta de diversas informações importantes e, adicionalmente, a utilização de exames complementares ajuda a definir o diagnóstico e prognóstico de cada caso. O objetivo principal deste trabalho foi aplicar a análise de correspondência múltipla (ACM) em dados referentes ao exame clínico e desfecho de cavalos com cólica encaminhados para um hospital no Rio Grande do Sul, Brasil. Foram incluídos 58 cavalos na análise e foi possível identificar diferenças significativas entre os grupos, sobreviventes e não sobreviventes. Relacionado aos sinais clínicos, os casos de óbito distinguem-se por dor intensa, falta de motilidade, alteração da mucosa, tempo de preenchimento capilar maior que 2seg., frequência cardíaca maior que 48bpm e presença de refluxo nasogástrico. Como exames complementares, o hematócrito e o lactato sanguíneo demonstraram diferença significativa entre os grupos. Os parâmetros cardiovasculares, como batimento cardíaco, coloração de mucosas e tempo de preenchimento capilar, foram as variáveis com maior contribuição para diferenciar animais que não sobreviveram dos que receberam alta hospitalar. Assim, a avaliação clínica não deve ser subestimada e os exames complementares devem ser utilizados em conjunto para buscar um melhor prognóstico. A ACM permitiu visualizar os dados e prever o desfecho dos pacientes. RESUMO equina paciente adicionalmente caso (ACM Sul Brasil 5 grupos clínicos distinguemse distinguem se intensa motilidade mucosa 2seg seg 2seg. bpm nasogástrico cardiovasculares cardíaco hospitalar Assim pacientes

ABSTRACT: Acute abdomen cases are among the most prevalent and challenging illnesses in equine medicine. The diagnosis includes anamnesis and detailed clinical evaluation of the patient, allowing the gathering of several important information and, additionally, the use of complementary exams helps to define the diagnosis and prognosis of each case. This research applied the multiple correspondence analysis (MCA) in data referring to clinical examination information and outcome of horses with colic referred to a hospital in Rio Grande do Sul, Brazil. Fifty eight horses were included in the analysis and, it was possible to identify significant differences between the groups, survivors and non-survivors. Related to clinical signs, non-survivor cases are distinguished by severe pain, lack of motility, mucosal alteration, capillary refill time greater than 2sec, heart rate more than 48bpm and presence of nasogastric reflux. As complementary exams, hematocrits and blood lactate demonstrate significative difference among the groups. The cardiovascular parameters, including heart rate, mucosal color and capillary refill time, were the variables with the greatest contribution to discriminate animals that non-survive from those that were discharged. Thus, clinical evaluation should not be underestimated and complementary exams should be used in conjunction to seek a better prognosis. The MCA allowed to visualize the data and predict the outcome of the patients. ABSTRACT medicine patient additionally case (MCA Sul Brazil groups nonsurvivors. nonsurvivors non survivors. non-survivors signs nonsurvivor survivor pain motility alteration 2sec sec bpm reflux parameters nonsurvive survive discharged Thus patients

Worldwide, millions of people suffer from neurological and psychiatric conditions, such as schizophrenia, depression, and neurodegenerative diseases. These conditions are often linked to hyperactivity of monoamine oxidase B (MAO-B) in the brain, and inhibiting this enzyme can reduce oxidative stress, stabilize neurotransmitter levels, and alleviate symptoms. In this context, a pharmacophoric model was created using PharmaGist with 31 hits extracted from BindingDB to enable a pharmacophoric-based search of potential MAO-B inhibitors in ZincPharmer’s chemical space, followed by the building of 10 conformers for each molecule in the software OMEGA, screening for structural and electrostatic similarity to safinamide using ROCS (Rapid overlay of chemical structures) and EON (Electrostatic similarity for lead-hopping), respectively. In addition, the molecular docking with Gold using the score function was performed to rank the ligands with the highest probabilities of affinity to MAO-B and then discriminate those with suitable physical chemical, pharmacokinetic, and toxicological features using the tools QikProp, SwissADME, and DEREK. Four potential ligands with selective MAO-B inhibitor properties were identified, which show promise as future therapeutic agents for MAO-B-related disorders. Worldwide schizophrenia depression diseases MAOB MAO (MAO-B brain stress levels symptoms context 3 pharmacophoricbased based ZincPharmers ZincPharmer s space 1 OMEGA Rapid structures Electrostatic leadhopping, leadhopping lead hopping , lead-hopping) respectively addition pharmacokinetic QikProp SwissADME DEREK identified MAOBrelated related disorders lead-hopping

Resumo Objetivo Avaliar o estresse laboral, a satisfação e a motivação para o trabalho de profissionais de enfermagem de bloco operatório no Brasil. Métodos Estudo do tipo open survey nacional, realizado entre os meses de agosto e dezembro de 2023. Utilizou-se Escala de Satisfação no Trabalho - EST, o questionário de Motivação para o trabalho e a Escala de Estresse no Trabalho – EET em um formulário online. Resultados Houve um total de 385 respostas, sendo 160 profissionais (41,6%) técnicos ou auxiliares de enfermagem e 225(58,4%) enfermeiros. Houve elevada parcela de profissionais com níveis de estresse entre moderado e elevado (72,98%), tendo sido significativo o resultado de maior estresse moderado a elevado nos profissionais do turno diurno (p=0,01) e sem diferença por gênero nem faixa etária. Não houve diferença estatisticamente significativa entre as variáveis para técnicos e enfermeiros, nem em função do tipo de vínculo. Ter dois ou mais empregos e trabalhar em horários diurnos está associado a maior percepção de estresse relacionado ao trabalho. Conclusão A elevada proporção de profissionais técnicos de enfermagem e enfermeiros com estresse moderado e elevado merece destaque entre os achados da pesquisa. laboral Brasil nacional 2023 Utilizouse Utilizou se EST online 38 respostas 16 41,6% 416 41 6 (41,6% 22558,4% 225584 225 58,4% 58 4 225(58,4% 72,98%, 7298 72,98% , 72 98 (72,98%) p=0,01 p001 p 0 01 (p=0,01 etária vínculo pesquisa 202 3 1 41,6 (41,6 22558 22558,4 22 584 58,4 5 225(58,4 729 72,98 7 9 (72,98% p=0,0 p00 (p=0,0 20 41, (41, 2255 22558, 2 58, 225(58, 72,9 (72,98 p=0, p0 (p=0, (41 225(58 72, (72,9 p=0 (p=0 (4 225(5 (72, p= (p= ( 225( (72 (p (7

Abstract Objective Evaluating job stress, job satisfaction and job motivation among operating room nurses in Brazil. Methods This was a national open-ended survey carried out between August and December 2023. The Work Satisfaction Scale (WSS), the Motivation for Work questionnaire and the Work Stress Scale (WSS) were used in an online form. Results There were a total of 385 responses, of which 160 professionals (41.6%) were nursing technicians or assistants and 225 (58.4%) were nurses. There was a high proportion of professionals with moderate to high levels of stress (72.98%), with a significant result of greater moderate to high stress in day shift professionals (p=0.01) and no difference by gender or age group. There was no statistically significant difference between the variables for technicians and nurses, nor according to the type of employment. Having two or more jobs and working daytime hours is associated with a higher perception of work-related stress. Conclusion The high proportion of nursing technicians and nurses with moderate and high stress deserves to be highlighted among the research findings. Brazil openended open ended 2023 WSS, WSS , (WSS form 38 responses 16 41.6% 416 41 6 (41.6% 22 58.4% 584 58 4 (58.4% 72.98%, 7298 72.98% 72 98 (72.98%) p=0.01 p001 p 0 01 (p=0.01 group employment workrelated work related findings 202 3 1 41.6 (41.6 2 58.4 5 (58.4 729 72.98 7 9 (72.98% p=0.0 p00 (p=0.0 20 41. (41. 58. (58. 72.9 (72.98 p=0. p0 (p=0. (41 (58 72. (72.9 p=0 (p=0 (4 (5 (72. p= (p= ( (72 (p (7

Resumen Objetivo Evaluar el estrés laboral, la satisfacción y la motivación para trabajar de profesionales de enfermería del bloque operatorio en Brasil. Métodos Estudio tipo open survey nacional, realizado entre los meses de agosto y diciembre de 2023. Se utilizó la Escala de Satisfacción Laboral (ESL), el Cuestionario de Motivación para el Trabajo y la Escala de Estrés Laboral (EEL) en un formulario digital. Resultados Hubo un total de 385 respuestas, de las cuales 160 fueron de profesionales (41,6 %) técnicos o auxiliares de enfermería y 225 (58,4 %) enfermeros. Hubo una elevada porción de profesionales con niveles de estrés entre moderado y alto (72,98 %), donde fue significativo el resultado de más estrés de moderado a alto entre los profesionales del turno diurno (p=0,01) y sin diferencia por género ni grupo de edad. No se observó diferencia estadísticamente significativa entre las variables de técnicos y enfermeros, ni en función del tipo de vínculo. El hecho de tener dos o más empleos y trabajar en horarios diurnos se asoció a una mayor percepción de estrés relacionado con el trabajo. Conclusión La elevada proporción de profesionales técnicos de enfermería y enfermeros con estrés de moderado a alto se destaca entre los resultados del estudio. laboral Brasil nacional 2023 ESL, ESL , (ESL) EEL (EEL digital 38 respuestas 16 41,6 416 41 6 (41, % 22 58,4 584 58 4 (58, 72,98 7298 72 98 (72,9 %, p=0,01 p001 p 0 01 (p=0,01 edad vínculo trabajo estudio 202 (ESL 3 1 41, (41 2 58, 5 (58 72,9 729 7 9 (72, p=0,0 p00 (p=0,0 20 (4 (5 72, (72 p=0, p0 (p=0, ( (7 p=0 (p=0 p= (p= (p

RESUMO: Botulismo é causado pela ingestão de toxinas pré-fromadas produzidas por Clostridium botulinum. Este estudo descrevre um surto de botulismo tipo D em um rebanho bovino, com alta taxa de mortalidade (67%), devido ao consumo de silagem mal acondicionada. Os bovinos afetados apresentaram curso clínico hiperagudo e agudo de paralisia flácida progressiva. Cinco animais foram necropsiados e não foram visualizadas alterações macroscópicas e microscópicas. Embora a toxina não tenha sido detectada no alimento, a fonte mais provável de contaminação foi considerada a silagem armazenada inadequadamente. O diagnóstico de botulismo foi baseado nos achados clínicos, epidemiológicos e pela detecção da toxina botulínica no conteúdo intestinal de dois bovinos. O presente estudo enfatiza a morte de muitos bovinos por uma fonte incomum de toxina botulínica e a importância do manejo adequado no fornecimento de ração aos animais. RESUMO préfromadas pré fromadas botulinum bovino 67%, 67 67% , (67%) acondicionada progressiva microscópicas alimento inadequadamente clínicos 6 (67% (67 (6 (

ABSTRACT: Botulism is a condition caused by the ingestion of pre-formed toxins produced by the bacterium Clostridium botulinum. This study described an outbreak of type D botulism with a high mortality rate (67%) in a cattle herd, caused by the consumption of fermented silage. The affected cattle presented with a hyperacute to acute clinical course with progressive flaccid paralysis. Five animals underwent necropsy with no significant macroscopic and microscopic alterations. A most probable source of contamination was deemed to be an inadequately stored silage; although, the toxin was not detected in the feed. The diagnosis of botulism was based on both clinical and epidemiological findings and the detection of botulinum toxin in the intestinal contents of two of the affected cattle. The present study emphasized the high number of fatally affected cattle, an unusual source of botulinum toxin and the importance of proper management of animal feed supply. ABSTRACT preformed pre formed 67% 67 (67% herd silage paralysis alterations although supply 6 (67 (6 (

Jaboticaba peel powder (JPP) is a residue that contains phenolic compounds, such as anthocyanins and gallic acid. An adsorbent-bioactive complex (ABC) was synthesized using an extract rich in compounds with antioxidant properties obtained from JPP immobilized on microcrystalline cellulose from sweet sorghum bagasse. In this work, the result of thermal degradation of anthocyanins from JPP and ABC, activation energy (Ea), half-life time (t1/2), decimal reduction time (D), temperature variation (Z), thermodynamic parameters (enthalpy (ΔH), Gibbs free energy (ΔG) and entropy (ΔS)) and degradation of antioxidant activities were investigated. Anthocyanin degradation of 35, 60 and 85% was observed for JPP and 10, 30 and 65% for ABC at temperatures of 90-130 °C. Ea of JPP and ABC were 110 and 91 kJ mol-1, respectively. ABC was able to increase from 143-690% the half-life time when compared to JPP. The Z parameter indicated that a greater temperature variation is necessary to degrade ABC anthocyanins (31 °C) when compared to JPP (25 °C). The thermodynamic parameters showed that the energy needed to be broken down to reach the transition state is higher for JPP than ABC, in addition ABC is closer to its thermodynamic equilibrium state. Thus, ABC can be used as an additive in pharmaceutical, cosmetics and food industries, maintaining bioactive and antioxidant properties. (JPP acid adsorbentbioactive adsorbent (ABC bagasse work Ea, , (Ea) halflife half life t1/2, t12 t t1/2 t1 2 (t1/2) D, D (D) Z, (Z) enthalpy ΔH, ΔH (ΔH) ΔG (ΔG ΔS (ΔS) investigated 35 6 85 10 3 65 90130 90 130 90-13 C °C 11 9 mol1, mol1 mol 1, 1 mol-1 respectively 143690% 143690 143 690% 690 143-690 31 (3 25 (2 . Thus pharmaceutical industries (Ea t1/ (t1/2 (D (Z (ΔH (ΔS 8 9013 13 90-1 mol- 14369 14 69 143-69 ( (t1/ 901 90- 1436 143-6 (t1 143- (t

In this study, we aimed to investigate the anticancer activity of the extract, fractions, and isolated compounds of the flowers of Fridericia platyphylla, and to characterize the bioactive compounds. The chemical diversity of the extracts and fractions was investigated using liquid chromatography coupled with high resolution mass spectrometry (LC-HRMS). We were able to annotate 26 compounds from the classes of flavones, flavonols, flavanones, isoflavones, and cinnamic acid and its derivatives. The dichloromethane fraction showed greater cytotoxicity at a concentration of 100 µg mL−1. In addition, the inhibitory concentrations of the dichloromethane fraction were 22.14 and 30.9 µg mL−1 for MCF-7 and MDA-MB-231 cell lines, respectively, and were capable of inhibiting tumor cell migration. Brachydins A and C were isolated from the dichloromethane fraction and showed the greatest cytotoxicity. The results obtained from this study show the potential biological effect of F. platyphylla flowers as a possible antitumor pharmacological agent. extract LCHRMS. LCHRMS LC HRMS . (LC-HRMS) 2 flavones flavonols flavanones isoflavones derivatives 10 mL1 mL 1 addition 2214 22 14 22.1 309 30 9 30. mL− MCF7 MCF 7 MCF- MDAMB231 MDAMB MDA MB 231 MDA-MB-23 lines respectively migration F agent (LC-HRMS 221 22. 3 MDAMB23 23 MDA-MB-2 MDAMB2 MDA-MB- MDA-MB

ABSTRACT Currently with a more demanding market, is necessary to produce better and high physiological quality cultivars of soybeans. In front of this new challenge, our objective was to evaluate the physiological quality of 11 soybean cultivars: CD201, SYN1263, SYN1279, BMX, UFLA1, CA115, CD215, CD202, Conquista, Savana, and BRS820 storage for 12 months. Evaluations were conducted through physiological like germination and vigor (accelerated aging and controlled deterioration) and isoenzymes analysis. The seeds were stored under controlled conditions at 10 °C and 10% relative humidity. It was assessed every four months (0, 4, 8, and 12). 200 seeds per treatment were used for each test, divided into 4 replications of 50 seeds. The number of normal plants was evaluated on the fifth and seventh days, expressed as a percentage value. Isoenzyme analysis of MDH, ADH, Esterase, and Catalase was made. The results were interpreted from the presence or absence of bands in the gel. An experimental design in randomized complete blocks, interpreting data using analysis of variance in a factorial scheme 11 x 4 (11 cultivars and 4 times of storage and averages compared by the test Scott-Knott 5% of probability and regression analysis. The statistical program used was Sisvar®. We found that cultivars Savana and Conquista showed low physiological quality, and the cultivars CD 215 and BMX showed high physiological quality during storage. market soybeans challenge 1 CD201 SYN1263 SYN SYN1279 UFLA1 UFLA CA115 CA CD215 CD202 BRS BRS82 accelerated deterioration C humidity 0, 0 (0 8 12. . 12) 20 5 days value MDH ADH Esterase made gel blocks (1 ScottKnott Scott Knott Sisvar Sisvar® 21 CD20 SYN126 SYN127 CA11 CD21 BRS8 ( 2 CD2 SYN12 CA1 SYN1

In this work, the innovation process to take chemical technologies born in universities to the market is described. The discussion is structured on the stages: research/science, patenting, opportunity evaluation, scale-up and proof of concept that lead to two possible outputs: technology transfer or startup creation. The work also describes the activities of Escalab, a UFMG technology lab, in the innovation process: technological mapping/R&D for the industry, technology scale up, technology acceleration, open innovation programs with industry and the program “go-to-market” for the insertion of chemical startups in market. It is expected that this experience should motivate academic chemistry researchers to push their technologies to the market. described stages researchscience research science research/science patenting evaluation scaleup up outputs creation Escalab lab mappingRD mapping R D acceleration gotomarket go “go-to-market

ABSTRACT Planting is considered one of the most essential steps in coffee growing. Lack of uniformity in planting may compromise future operations. Therefore, verifying planting operations quality is fundamental to optimizing production processes and reducing costs. This study aimed to investigate planting techniques through Statistical Process Control (SPC) and aerial images. Carried out in two areas, managed manually and semi-mechanized in the Bom Jardim Farm (MG - Brazil). Data were collected through Remotely Piloted Aircraft (RPA). Quality control charts and density maps were used to identify variations in distribution and spacing between plants and planting rows. It was found that the planting carried out manually was 4.7% wider than projected due to spacing reduction from 0.5 m to 0.48 m. The semi-mechanized system displayed a deficit of 7% compared to the projected planting system, using 0.55 m between plants. The density map showed the most significant planting alignment variations. Despite displaying lower results than the manual system, the semi-mechanized system improvements are valid for their minimal average variations. Thus, correcting points found outside the limits can increase the efficiency of semi-mechanized planting. growing Therefore costs SPC (SPC images areas semimechanized semi mechanized MG Brazil. Brazil . Brazil) RPA. RPA (RPA) rows 47 4 7 4.7 05 0 5 0. 048 48 0.4 055 55 Thus (RPA 4. 04

We report a facile hydrothermal method for the synthesis of niobium pentoxide (Nb2O5) under two different temperatures, 120 °C (Nb2O5-120) and 150 °C (Nb2O5-150). The obtained materials were characterized by structural, optical and morphological techniques. Also, the photocatalytic properties of the Nb2O5 samples were evaluated in two reactions under ultraviolet (UVC) irradiation: degradation of methylene blue (MB) and indigo carmine (IC) dyes; and esterification of free fatty acids (FFA) present in waste cooking oil (WCO). The Nb2O5 was formed at different temperatures of synthesis, and the increase in temperature did not cause significant changes in the structural and optical characteristics, but resulted in an increased surface area of the synthesized materials. Both synthesized materials showed excellent efficiency for dye photodegradation. The sample Nb2O5-150 presented the best performance for the MB photodegradation, with almost 85% of the removal efficiency. In this case, the adsorption of MB molecules on the surface of the material was high due to the favorable electrostatic interaction and also because of its high surface area. For the IC photodegradation, the adsorption was insignificant, and both samples presented approximately 100% of the removal efficiency. These materials were also promising for the reduction of free fat acids in waste oil by photoesterification. NbO Nb O (Nb2O5 12 C Nb2O5120 (Nb2O5-120 15 Nb2O5150. Nb2O5150 . (Nb2O5-150) techniques Also Nb2O UVC (UVC irradiation (MB (IC dyes FFA (FFA WCO. WCO (WCO) characteristics photodegradation Nb2O5-15 85 case insignificant 100 photoesterification (Nb2O 1 Nb2O512 (Nb2O5-12 Nb2O515 (Nb2O5-150 (WCO Nb2O5-1 8 10 Nb2O51 (Nb2O5-1 (Nb2O5-15 Nb2O5- (Nb2O5-