ABSTRACT Introduction Chemotherapy and radiation therapy are considered standard treatments for stage II seminoma patients; however, these therapies are associated with long-term toxicities. Recently, retroperitoneal lymph node dissection has emerged as an alternative strategy, and the first three phase II trials were published in 2023 with promising results. The present study conducted a systematic review and meta-analysis to evaluate this surgery as an alternative treatment for stage IIA/B seminoma patients. Purpose Seminomas are the most common testicular tumors, often affecting young adult males. Standard treatments for stage II seminomas include chemotherapy and radiation therapy, but these therapies are associated with long-term toxicities. Thus, identifying alternative strategies is paramount. Herein, we conducted a systematic review and meta-analysis to appraise the efficacy and safety of retroperitoneal lymph node dissection (RPLND) for treating this condition. Methods We systematically searched the PubMed, Embase, and Cochrane databases for studies evaluating RPLND as a primary treatment for stage II A/B seminomas. Using a random-effects model, single proportion and means and pooled 2-year recurrence-free survival rates with hazard rates and 95% CI were calculated. Results Seven studies were included, comprising 331 males with stage II seminomas. In the pooled analysis, the recurrence rate was 17.69% (95% CI 12.31–24.75), and the 2-year RFS rate was 81% (95% CI 0.77–0.86). The complication rate was 9.16% (95% CI 6.16–13.42), the Clavien–Dindo > 2 complication rate was 8.83% (95% CI 5.76–13.31), and the retrograde ejaculation rate was 7.01% (95% CI 3.54–13.40). The median operative time was 174.68 min (95% CI 122.17–249.76 min), median blood loss was 105.91 mL (95% CI 46.89–239.22 mL), and patients with no evidence of lymph node involvement ranged from 0–16%. Conclusions Primary RPLNDs for treating stage IIA/B seminomas have favorable RFS rates, with low complication and recurrence rates. These findings provide evidence that this surgery is a viable alternative therapy for these patients. however longterm long term toxicities Recently strategy 202 results metaanalysis meta analysis IIAB IIA B tumors Thus paramount Herein (RPLND condition PubMed Embase AB A randomeffects random effects model 2year year recurrencefree free 95 calculated included 33 1769 17 69 17.69 (95 12.31–24.75, 12312475 12.31–24.75 , 12 31 24 75 12.31–24.75) 81 0.77–0.86. 077086 0.77–0.86 . 0 77 86 0.77–0.86) 916 9 16 9.16 6.16–13.42, 6161342 6.16–13.42 6 13 42 6.16–13.42) ClavienDindo Clavien Dindo 883 8 83 8.83 5.76–13.31, 5761331 5.76–13.31 5 76 5.76–13.31) 701 7 01 7.01 3.54–13.40. 3541340 3.54–13.40 3 54 40 3.54–13.40) 17468 174 68 174.6 1221724976 122 249 122.17–249.7 min, min) 10591 105 91 105.9 468923922 46 89 239 22 46.89–239.2 mL, mL) 016 0–16% 20 176 1 17.6 (9 1231247 12.31–24.7 07708 0.77–0.8 9.1 616134 6.16–13.4 4 88 8.8 576133 5.76–13.3 70 7.0 354134 3.54–13.4 1746 174. 122172497 122.17–249. 1059 10 105. 46892392 23 46.89–239. 0–16 17. ( 123124 12.31–24. 0770 0.77–0. 9. 61613 6.16–13. 8. 57613 5.76–13. 7. 35413 3.54–13. 12217249 122.17–249 4689239 46.89–239 0–1 12312 12.31–24 077 0.77–0 6161 6.16–13 5761 5.76–13 3541 3.54–13 1221724 122.17–24 468923 46.89–23 0– 1231 12.31–2 07 0.77– 616 6.16–1 576 5.76–1 354 3.54–1 122172 122.17–2 46892 46.89–2 123 12.31– 0.77 61 6.16– 57 5.76– 35 3.54– 12217 122.17– 4689 46.89– 12.31 0.7 6.16 5.76 3.54 1221 122.17 468 46.89 12.3 0. 6.1 5.7 3.5 122.1 46.8 12. 6. 5. 3. 122. 46.

We report an ab initio study on the kinetics and chemical dynamics of the CH4 + CH reaction using a coupled cluster based composite scheme that includes unrestricted coupled cluster singles and doubles with perturbative connected triples method, UCCSD(T), energies extrapolated to the complete basis set limit, in addition to core-valence, higher-order correlation, and relativistic corrections. With this protocol, the reaction enthalpies for the two main reaction channels, C2H4 + H and CH2 + CH3, are reproduced with an absolute deviation of 0.04 kcal mol–1 relative to experimental data. At the UCCSD(T)/complete basis set (CBS) level of theory, the formation of the C2H5 intermediate is barrierless, in contrast with the low submerged barrier (–1.87 kcal -mol–1 relative to the reactants) found at the UCCSD(T)/augmented correlation-consistent polarized double-zeta (aug-cc-pVDZ) level of theory. With the correlation-consistent polarized triple-zeta (cc-pVTZ) basis set, we describe structural variations for the reaction bottleneck along the reaction path, finding at least three canonical variational transition states for the temperature range from 20 to 800 K. The thermal rates were obtained via the canonical unified statistical theory (CUS), using the canonical variational transition state theory (VTST) for the inner-transition state and long-range transition state theory (LRTST) for the outer-transition state. Our calculations agree with literature measurements and show inverse Arrhenius behavior, as observed experimentally. At 298 K, the computed rate constant is 2.65 × 10–10 cm3 molecule–1 s–1 and reported experimental measurements range from 2.5 × 10–12 to 3.0 × 10–10 cm3 molecule–1 s–1. Our theoretical study represents an improvement on previous computational investigations and highlights that even relatively simple gas-phase reactions can require high levels of theory to be modeled accurately. method UCCSDT, UCCSDT UCCSD T , UCCSD(T) limit corevalence, corevalence core valence, valence core-valence higherorder higher order correlation corrections protocol channels C C2H CH3 004 0 04 0.0 mol1 mol 1 mol– data UCCSDT/complete UCCSDTcomplete /complete CBS (CBS barrierless –1.87 187 87 (–1.8 -mol– reactants UCCSDT/augmented UCCSDTaugmented /augmented augmented correlationconsistent consistent doublezeta double zeta augccpVDZ aug cc pVDZ (aug-cc-pVDZ triplezeta triple ccpVTZ pVTZ (cc-pVTZ path 2 80 K CUS, CUS (CUS) VTST (VTST innertransition inner longrange long LRTST (LRTST outertransition outer behavior experimentally 29 265 65 2.6 1010 10 10–1 cm molecule1 molecule molecule– s1 s s– 25 5 2. 1012 12 30 3 3. gasphase gas phase accurately UCCSD(T 00 0. –1.8 18 8 (–1. -mol (CUS 26 6 101 10– –1. (–1 –1 (– – (

Abstract Objectives This study aimed to analyze the cost-effectiveness of whitening toothpastes and at-home bleaching for the treatment of tooth discoloration. Methodology A cost-effectiveness economic analysis was conducted, and eight randomized clinical trials were selected based on the whitening agent product used: blue covarine dentifrices (BCD), hydrogen peroxide dentifrices (HPD), dentifrices without bleaching agents (CD, negative control), and 10% carbamide peroxide (CP10, positive control) for at-home bleaching. The consumer/patient perspective was adopted, macro-costing techniques were used and a decision tree model was performed considering the costs in the American and Brazilian markets. The color change evaluation (ΔE*ab) was used to calculate the effectiveness of tooth bleaching. A probabilistic analysis was performed using a Monte Carlo simulation and incremental cost-effectiveness ratios were obtained. Results CP10 resulted in the highest cost-effectiveness compared to the use of dentifrices in both markets. In Brazil, HPD was more cost-effective than BCD and CD. In the US, the increased costs of HPD and BCD did not generate any whitening benefit compared to CD. Conclusions CP10 was more cost-effective than BCD and HPD for tooth bleaching from the perspectives of the Brazilian and American markets. Decision-making should consider the use of CP10 for treating tooth discoloration. costeffectiveness cost athome at home discoloration conducted BCD, , (BCD) HPD, (HPD) CD, CD (CD control, control 10 CP10, CP (CP10 consumerpatient consumer patient adopted macrocosting macro costing markets ΔE*ab ΔEab ΔE ab (ΔE*ab obtained CP1 Brazil costeffective effective US Decisionmaking Decision making (BCD (HPD 1 (CP1 (CP

RESUMO Objetivo Estimar a cobertura vacinal da hepatite A em crianças de 24 meses e identificar fatores associados à ausência de vacinação. Métodos Inquérito em amostra estratificada por estratos socioeconômicos em capitais (2020-2022), com estimativa de cobertura e intervalos de confiança de 95% (IC95%) e análise de fatores pela razão de prevalência (RP) via regressão de Poisson. Resultados Nas 31.001 crianças, a cobertura da hepatite A foi de 88,1% (IC95% 86,8;89,2). Nos estratos socioeconômicos (A/B), a variável pais/responsáveis imigrantes foi associada à ausência de vacinação (RP = 1,91; IC95% 1,09;3,37); nos estratos C/D, crianças de cor amarela (RP = 4,69; IC95% 2,30;9,57), 4ª ordem de nascimento ou mais (RP = 1,68; IC95% 1,06;2,66), não frequentar creche/berçário (RP = 1,67; IC95% 1,24;2,24) e mãe com trabalho remunerado (RP = 1,42; IC95% 1,16;1,74) foram associadas à ausência de vacinação. Conclusão Cobertura da hepatite A abaixo da meta (95%), sugerindo-se considerar especificidades dos estratos sociais.

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ABSTRACT Objective To estimate hepatitis A vaccination coverage in 24-month-old children and identify factors associated with non-vaccination. Methods This was a survey involving a sample stratified by socioeconomic strata in capital cities (2020-2022), with coverage estimates and 95% confidence intervals (95%CI), the factor analysis was performed using the prevalence ratio (PR) by means of Poisson regression. Results Among 31,001 children, hepatitis A coverage was 88.1% (95%CI 86.8;89.2). Regarding socioeconomic strata (A/B), the variable immigrant parents/guardians was associated with non-vaccination (PR = 1.91; 95%CI 1.09;3.37); in strata C/D, children of Asian race/skin color (PR = 4.69; 95%CI 2.30;9.57), fourth-born child or later (PR = 1.68; 95%CI 1.06;2 .66), not attending daycare/nursery (PR = 1.67; 95%CI 1.24;2.24) and mother with paid work (PR = 1.42; 95%CI 1.16;1.74) were associated with non-vaccination. Conclusion Hepatitis A coverage was below the target (95%), suggesting that specificities of social strata should be taken into consideration.

Resumo: O objetivo do estudo foi analisar a presença de infraestrutura e processo de trabalho adequados na atenção primária à saúde (APS) para o diagnóstico, o monitoramento e o tratamento da tuberculose (TB) no Brasil de 2012 a 2018. Estudo de tendência temporal realizado com dados das unidades básicas de saúde (UBS) avaliadas nos ciclos I (2012), II (2014) e III (2018) do Programa Nacional de Melhoria do Acesso e da Qualidade da Atenção Básica (PMAQ-AB). Foi empregada a regressão de mínimos quadrados ponderada por variância para estimar as mudanças anuais, em pontos percentuais da infraestrutura e processo de trabalho adequado da TB em relação à macrorregião, ao porte do município e ao Índice Municipal de Desenvolvimento Humano e cobertura da Estratégia Saúde da Família. A amostra foi composta por 13.842 UBS e 17.202 equipes de saúde no ciclo I, 24.055 UBS e 29.778 equipes no II e 28.939 UBS e 37.350 equipes no III. Observou-se melhora gradual na proporção de infraestrutura e processo de trabalho ao atendimento da TB ao longo dos três ciclos do PMAQ-AB; contudo, nenhum local está integralmente adequado. A maior tendência de infraestrutura adequada foi verificada na Região Sul e no ano de 2018, em que 76,5% das UBS tinham todos os instrumentos para o cuidado à TB. A maior tendência de processo de trabalho adequado foi na Região Norte e no ano de 2018, em que 50,8% das equipes tinham a totalidade de itens para o cuidado à TB. O Programa Nacional de Controle da Tuberculose e o PMAQ-AB contribuíram para tais avanços, mas ainda é necessário o fomento de políticas públicas que garantam a melhoria contínua da assistência à TB na APS e a eficácia das medidas de controle e prevenção da doença. Resumo (APS diagnóstico (TB 201 2018 (UBS 2012, , (2012) 2014 (2014 (2018 PMAQAB. PMAQAB PMAQ AB . (PMAQ-AB) anuais macrorregião Família 13842 13 842 13.84 17202 17 202 17.20 24055 24 055 24.05 29778 29 778 29.77 28939 28 939 28.93 37350 37 350 37.35 Observouse Observou se contudo 765 76 5 76,5 508 50 8 50,8 avanços doença 20 (2012 (201 (PMAQ-AB 1384 1 84 13.8 1720 17.2 2405 2 05 24.0 2977 77 29.7 2893 93 28.9 3735 3 35 37.3 7 76, 50, (20 138 13. 172 17. 240 0 24. 297 29. 289 9 28. 373 37. (2 (

Abstract: This study aimed to analyze the presence of infrastructure and adequate work processes in primary health care (PHC) for the diagnosis, monitoring, and treatment of tuberculosis (TB) in Brazil from 2012 to 2018. This is a temporal trend study carried out with data from basic health units (BHU) evaluated in the cycles I (2012), II (2014), and III (2018) of the Brazilian National Program for Improvement of Access and Quality of Basic Care (PMAQ-AB). Variance-weighted least-squares regression was used to estimate annual changes, in percentage points, of the infrastructure and adequate work process of TB in relation to the macroregion, municipality size, Municipal Human Development Index, and Family Health Strategy coverage. The sample consisted of 13,842 BHU and 17,202 health teams in cycle I; 24,055 BHU and 29,778 teams in cycle II; and 28,939 BHU and 37,350 teams in cycle III. There was a gradual improvement in the proportion of infrastructure and work process for TB care over the three cycles of the PMAQ-AB, but none of the sites is fully adequate. The greatest trend of adequate infrastructure was observed in the South Region, and in 2018, 76.5% of the UBS had all the instruments for TB care. The greatest trend of adequate work process was in the North Region, and in 2018, 50.8% of the teams had all the items for TB care. The Brazilian National Program for Tuberculosis Control and the PMAQ-AB have contributed to these advances, but there is still a need to promote public policies that ensure the continuous improvement of TB care in PHC, the effectiveness of TB control and prevention measures. Abstract PHC (PHC diagnosis monitoring (TB 201 2018 (BHU 2012, , (2012) 2014, 2014 (2014) (2018 PMAQAB. PMAQAB PMAQ AB . (PMAQ-AB) Varianceweighted Variance weighted leastsquares least squares changes points macroregion size Index coverage 13842 13 842 13,84 17202 17 202 17,20 24055 24 055 24,05 29778 29 778 29,77 28939 28 939 28,93 37350 37 350 37,35 PMAQAB, AB, Region 765 76 5 76.5 508 50 8 50.8 advances measures 20 (2012 (2014 (201 (PMAQ-AB 1384 1 84 13,8 1720 17,2 2405 2 05 24,0 2977 77 29,7 2893 93 28,9 3735 3 35 37,3 7 76. 50. (20 138 13, 172 17, 240 0 24, 297 29, 289 9 28, 373 37, (2 (

Resumen: El objetivo de este estudio fue analizar la presencia de infraestructura y proceso de trabajo adecuado en la atención primaria de salud (APS) para el diagnóstico, monitoreo y tratamiento de la tuberculosis (TB) en Brasil entre los años 2012 y 2018. Estudio de tendencia temporal realizado con datos de las unidades básicas de salud (UBS), evaluadas en los ciclos I (2012), II (2014) y III (2018) del Programa Nacional de Mejoría de Acceso y Calidad de la Atención Básica (PMAQ-AB). Se utilizó la regresión de mínimos cuadrados ponderada por varianza para estimar los cambios anuales, en puntos porcentuales de la infraestructura y el proceso de trabajo adecuado de la TB en relación con la macrorregión, el tamaño del municipio, el Índice Municipal de Desarrollo Humano y la cobertura de la Estrategia de Salud de la Familia. La muestra se compuso de 13.842 UBS y 17.202 equipos de salud en el ciclo I, 24.055 UBS y 29.778 equipos en el ciclo II y 28.939 UBS y 37.350 equipos en el ciclo III. Se observó una mejoría gradual en la proporción de infraestructura y proceso de trabajo en la atención de la TB a lo largo de los tres ciclos del PMAQ-AB, sin embargo, ningún local está completamente adecuado. Se verificó la mayor tendencia de infraestructura adecuada en la Región Sur y, en 2018, el 76,5% de las UBS tenían todas las herramientas para el cuidado de la TB. La Región Norte tuvo la mayor tendencia de proceso de trabajo adecuado y, en 2018, el 50,8% de los equipos tenían todo lo necesario para el cuidado de la TB. El Programa Nacional de Control de la Tuberculosis y el PMQA-AB contribuyeron para estos avances, pero aún es necesario promover políticas públicas que aseguren la mejoría continua de la asistencia de la TB en la APS y la eficacia de las medidas de control y prevención de la enfermedad. Resumen (APS diagnóstico (TB 201 2018 UBS, , (UBS) 2012, (2012) 2014 (2014 (2018 PMAQAB. PMAQAB PMAQ AB . (PMAQ-AB) anuales macrorregión municipio Familia 13842 13 842 13.84 17202 17 202 17.20 24055 24 055 24.05 29778 29 778 29.77 28939 28 939 28.93 37350 37 350 37.35 PMAQAB, AB, PMAQ-AB embargo 765 76 5 76,5 508 50 8 50,8 PMQAAB PMQA avances enfermedad 20 (UBS (2012 (201 (PMAQ-AB 1384 1 84 13.8 1720 17.2 2405 2 05 24.0 2977 77 29.7 2893 93 28.9 3735 3 35 37.3 7 76, 50, (20 138 13. 172 17. 240 0 24. 297 29. 289 9 28. 373 37. (2 (

ABSTRACT Maize landraces diversity is important for many smallholder and indigenous populations. Gene flow constitutes a threat to the genetic conservation of several locally adapted maize landraces and, risk management depends on monitoring transgenic occurrence in non-GM maize. This study evaluated the occurrence of exogenous proteins from GM-maize in maize landraces and teosinte cultivated in the Alto Jequitinhonha region, State of Minas Gerais. Gene flow from GM maize to non-transgenic varieties was evaluated in eight maize groups and one teosinte variety. A transgenic maize variety was used as a positive control. Proteins Cry1F and Cry2Ab2 were monitored using the Protein Detection Assay kit (Envirologix QuickStix® kit protocols for detecting Cry1F and Cry2Ab2 proteins). Transgenic proteins were not detected in the leaves of landraces and teosinte cultivated in the Alto Jequitinhonha region. populations nonGM non GMmaize region Gerais nontransgenic control CryF Cry F CryAb Ab Cry2Ab Envirologix QuickStix proteins. . proteins)

Resumo O objetivo foi verificar a intenção de atuar no SUS de estudantes de bacharelado em Educação Física de três instituições públicas do Paraná. 349 estudantes responderam questionário sobre informações sociodemográficas, percepções sobre o Sistema único de Saúde (SUS), conhecimento sobre Programas Públicos para Práticas Corporais e Atividades Físicas (PCAF) e intenção de atuação profissional no SUS, especificamente em Unidades Básicas de Saúde (UBS), hospitais que atendem SUS e Centros de Atenção Psicossocial (CAPS). Cerca de quatro em cada 10 estudantes referiram ter intenção de atuar em ao menos uma das possibilidades analisadas: 30,4% em UBS, 27,5% em hospitais e 24,6% nos CAPS. As prevalências foram maiores entre as mulheres, entre os que referiram avaliação mais positiva sobre o SUS, entre os que conheciam programas públicos que ofereciam PCAF e naqueles que já tinham ouvido falar do Núcleo de Apoio à Saúde da Família (NASF-AB) e do Programa Academia da Saúde antes de entrar na universidade. Paraná 34 sociodemográficas , (SUS) (PCAF UBS (UBS) CAPS . (CAPS) 1 analisadas 304 30 4 30,4 275 27 5 27,5 246 24 6 24,6 mulheres NASFAB NASF AB (NASF-AB universidade 3 (SUS (UBS (CAPS 30, 2 27, 24,

Abstract The objective was to verify the intention of working in the Unified Health System (SUS) of Bachelor’s students in Physical Education from three public institutions in Paraná. 349 students answered a questionnaire about sociodemographic information, perceptions about the SUS, knowledge about public programs for physical activities and intention to work in the SUS, specifically in Basic Health Units (UBS), hospitals serving the SUS and Psychosocial Care Centers (CAPS). Around four out of every 10 students reported their intention to work in at least one of the possibilities analyzed, 30.4% in UBS, 27.5% in hospitals and 24.6% in CAPS. The prevalence was higher among women, among those who reported a more positive assessment of the SUS, among those who were aware of public programs that offered physical activities and among those who had already known other public health programs before entering university. (SUS Bachelors Bachelor s Paraná 34 information UBS , (UBS) CAPS . (CAPS) 1 analyzed 304 30 4 30.4 275 27 5 27.5 246 24 6 24.6 women university 3 (UBS (CAPS 30. 2 27. 24.

Resumen El objetivo fue verificar la intención de trabajar en el Sistema Único de Salud (SUS) de estudiantes de Educación Física de tres instituciones públicas de Brasil. 349 estudiantes respondieron un cuestionario sobre información sociodemográfica, percepciones sobre el SUS, conocimientos sobre programas públicos e intención de actuar profesionalmente en el SUS, específicamente en Unidades Básicas de Salud (UBS), hospitales que atienden el SUS y Centros de Atención Psicosocial (CAPS). Alrededor de cuatro de cada 10 estudiantes reportaron su intención de trabajar en al menos una de las posibilidades analizadas: 30,4% en la UBS, 27,5% en hospitales y 24,6% en CAPS. La prevalencia fue mayor entre las mujeres, entre quienes reportaron una evaluación más positiva del SUS, entre aquellos que conocían los programas públicos que promovían la actividad física y otros programas de salud pública antes de ingresar a la universidad. (SUS Brasil 34 sociodemográfica UBS , (UBS) CAPS . (CAPS) 1 analizadas 304 30 4 30,4 275 27 5 27,5 246 24 6 24,6 mujeres universidad 3 (UBS (CAPS 30, 2 27, 24,

RESUMO Objetivo Analisar fatores associados à cobertura vacinal completa com doses válidas, em crianças das capitais e em três outras cidades da região sudeste. Métodos Trata-se de análise de inquérito populacional conduzido em 2020-2021, em amostra estratificada segundo níveis socioeconômicos de crianças nascidas em 2017-2018, com dados coletados por registro fotográfico da caderneta de vacinação. Foram estimadas razões de chances (odds ratio, OR) e intervalo de confiança de 95% (IC95%) da cobertura vacinal completa pelas características da família, mãe e criança. Resultados Em 8.703 crianças, menor cobertura ocorreu nos estratos A e B (OR=0,39; IC95% 0,23;0,67 e OR=0,38; IC95% 0,25;0,58); nível de consumo A/B (OR=0,38; IC95% 0,28;0,52); renda mensal inferior a R$ 8.000,00 (OR=0,23; IC95% 0,12;0,42); em filhos de mães com ensino superior (OR=0,47; IC95% 0,32;0,71); em crianças não vacinadas exclusivamente no serviço público (OR=0,37; IC95% 0,26;0,51) e com atraso vacinal até 6 meses (OR=0,28; IC95% 0,22;0,37). Conclusão As coberturas não atingiram metas para controlar doenças imunopreveníveis e associaram-se negativamente ao maior nível socioeconômico. válidas sudeste Tratase Trata se 20202021, 20202021 2020 2021, 2021 2020-2021 20172018, 20172018 2017 2018, 2018 2017-2018 vacinação odds ratio OR 95 IC95 IC (IC95% família criança 8703 8 703 8.70 OR=0,39 OR039 0 39 (OR=0,39 0,230,67 023067 0,23 0,67 23 67 0,23;0,6 OR=0,38 OR038 38 0,250,58 025058 0,25 0,58 25 58 0,25;0,58) AB (OR=0,38 0,280,52 028052 0,28 0,52 28 52 0,28;0,52) R 800000 000 00 8.000,0 OR=0,23 OR023 (OR=0,23 0,120,42 012042 0,12 0,42 12 42 0,12;0,42) OR=0,47 OR047 47 (OR=0,47 0,320,71 032071 0,32 0,71 32 71 0,32;0,71) OR=0,37 OR037 37 (OR=0,37 0,260,51 026051 0,26 0,51 26 51 0,26;0,51 OR=0,28 OR028 (OR=0,28 0,220,37. 022037 0,22 0,37 . 22 0,22;0,37) associaramse associaram socioeconômico 2020202 202 2020-202 2017201 201 2017-201 9 IC9 (IC95 870 70 8.7 OR=0,3 OR03 3 (OR=0,3 230 0,230,6 02306 023 0,2 067 0,6 2 0,23;0, 250 0,250,5 02505 025 058 0,5 5 0,25;0,58 280 0,280,5 02805 028 052 0,28;0,52 80000 8.000, OR=0,2 OR02 (OR=0,2 120 0,120,4 01204 012 0,1 042 0,4 1 4 0,12;0,42 OR=0,4 OR04 (OR=0,4 320 0,320,7 03207 032 0,3 071 0,7 7 0,32;0,71 260 0,260,5 02605 026 051 0,26;0,5 220 0,220,37 02203 022 037 0,22;0,37 202020 20 2020-20 201720 2017-20 (IC9 87 8. OR=0, OR0 (OR=0, 0,230, 0230 02 0, 06 0,23;0 0,250, 0250 05 0,25;0,5 0,280, 0280 0,28;0,5 8000 8.000 0,120, 0120 01 04 0,12;0,4 0,320, 0320 03 07 0,32;0,7 0,260, 0260 0,26;0, 0,220,3 0220 0,22;0,3 20202 2020-2 20172 2017-2 (IC OR=0 (OR=0 0,230 0,23; 0,250 0,25;0, 0,280 0,28;0, 800 8.00 0,120 0,12;0, 0,320 0,32;0, 0,260 0,26;0 0,220, 0,22;0, 2020- 2017- OR= (OR= 0,25;0 0,28;0 80 8.0 0,12;0 0,32;0 0,26; 0,220 0,22;0 (OR 0,25; 0,28; 0,12; 0,32; 0,22;

ABSTRACT Objective To analyze factors associated with full vaccination coverage with valid doses, in children from four state capitals and three other cities in Southeast Brazil. Method Analysis of a population survey conducted in 2020-2021, with a sample stratified according to socioeconomic levels of children born in 2017-2018, with data collected through photographic records of their vaccination cards. Odds ratios (OR) and 95% confidence intervals (95%CI) for full vaccination coverage were estimated based on the characteristics of the family, mother and child. Results Among 8703 children, lowest coverage occurred in strata A and B (OR=0.39; 95%CI 0.23;0.67 and OR=0.38; 95%CI 0.25;0.58); in consumption level A/B (OR=0.38; 95CI% 0.28;0.52); among those with income >BRL8000/month (OR=0.23; 95%CI 0.12;0.42); in children of mothers with higher education (OR=0.47; 95%CI 0.32;0.71); in children not vaccinated exclusively in the public service (OR=0.37; 95%CI 0.26;0.51) and in children with a vaccination delay of up to 6 months (OR=0.28; 95%CI 0.22;0.37). Conclusion Coverage did not reach the targets for controlling vaccine-preventable diseases and was negatively associated with higher socioeconomic status. doses Brazil 20202021, 20202021 2020 2021, 2021 2020-2021 20172018, 20172018 2017 2018, 2018 2017-2018 cards OR (OR 95 95CI CI (95%CI family child 870 OR=0.39 OR039 0 39 (OR=0.39 0.230.67 023067 0.23 0.67 23 67 0.23;0.6 OR=0.38 OR038 38 0.250.58 025058 0.25 0.58 25 58 0.25;0.58) AB (OR=0.38 0.280.52 028052 0.28 0.52 28 52 0.28;0.52) BRL8000month BRLmonth BRL8000 month BRL OR=0.23 OR023 (OR=0.23 0.120.42 012042 0.12 0.42 12 42 0.12;0.42) OR=0.47 OR047 47 (OR=0.47 0.320.71 032071 0.32 0.71 32 71 0.32;0.71) OR=0.37 OR037 37 (OR=0.37 0.260.51 026051 0.26 0.51 26 51 0.26;0.51 OR=0.28 OR028 (OR=0.28 0.220.37. 022037 0.22 0.37 . 22 0.22;0.37) vaccinepreventable vaccine preventable status 2020202 202 2020-202 2017201 201 2017-201 9 87 OR=0.3 OR03 3 (OR=0.3 230 0.230.6 02306 023 0.2 067 0.6 2 0.23;0. 250 0.250.5 02505 025 058 0.5 5 0.25;0.58 280 0.280.5 02805 028 052 0.28;0.52 BRL800 OR=0.2 OR02 (OR=0.2 120 0.120.4 01204 012 0.1 042 0.4 1 4 0.12;0.42 OR=0.4 OR04 (OR=0.4 320 0.320.7 03207 032 0.3 071 0.7 7 0.32;0.71 260 0.260.5 02605 026 051 0.26;0.5 220 0.220.37 02203 022 037 0.22;0.37 202020 20 2020-20 201720 2017-20 8 OR=0. OR0 (OR=0. 0.230. 0230 02 0. 06 0.23;0 0.250. 0250 05 0.25;0.5 0.280. 0280 0.28;0.5 BRL80 0.120. 0120 01 04 0.12;0.4 0.320. 0320 03 07 0.32;0.7 0.260. 0260 0.26;0. 0.220.3 0220 0.22;0.3 20202 2020-2 20172 2017-2 OR=0 (OR=0 0.230 0.23; 0.250 0.25;0. 0.280 0.28;0. BRL8 0.120 0.12;0. 0.320 0.32;0. 0.260 0.26;0 0.220. 0.22;0. 2020- 2017- OR= (OR= 0.25;0 0.28;0 0.12;0 0.32;0 0.26; 0.220 0.22;0 0.25; 0.28; 0.12; 0.32; 0.22;

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Resumo Uma nova espécie de cacto, Tacinga mirim (Cactacaeae: Opuntioideae), é descrita e ilustrada. Tacinga mirim é como uma miniatura de T. palmadora, até onde se sabe, endêmica do estado do Ceará, nordeste do Brasil. Apesar de algumas populações da nova espécie serem conhecidas desde 2009, elas vinham sendo erroneamente identificadas como T. palmadora. A descrição da nova espécie foi feita a partir de análise morfológica e cariotípica. Morfologicamente defere de T. palmadora pelo tamanho muito menor, o hábito semiprostrado, os segmentos menores e decíduos, a menor densidade de espinhos, flores um pouco maiores e com grande angulo de abertura, pericarpelo liso e o fruto globoso a obovóide, roxo quando maduro. O cariótipo de T. mirim difere de T. palmadora por ser tetraploide (ao invés de diplóide), por apresentar cromossomos duas vezes maiores, dos quais oito são submetacêntricos (diferindo do padrão cariotípico totalmente metacêntrico de T. palmadora). A distribuição da nova espécie está associada à Caatinga do embasamento cristalino do interior do Ceará, em altitudes relativamente baixas (190-360 m). A categoria de ameaça do novo táxon segundo a IUCN foi avaliada preliminarmente. Tanto a EOO como a AOO indicam que a espécie é ameaçada (EN-B1-2ab). cacto Cactacaeae (Cactacaeae Opuntioideae, Opuntioideae , Opuntioideae) ilustrada T sabe Ceará Brasil 2009 cariotípica semiprostrado decíduos espinhos abertura obovóide maduro ao diplóide, diplóide diplóide) diferindo . palmadora) 190360 190 360 (190-36 m. m m) preliminarmente ENB12ab. ENB12ab ENBab EN B1 2ab B ab (EN-B1-2ab) 200 19036 19 36 (190-3 ENB (EN-B1-2ab 20 1903 1 3 (190- 2 (190 (19 (1 (

Abstract A new species of cactus, Tacinga mirim (Cactaceae: Opuntioideae), is described and illustrated. Tacinga mirim is like a miniature version of T. palmadora, as far as is known, endemic to the state of Ceará, Northeastern Brazil. Although some populations of the new species have been known since 2009, they had been wrongly identified as T. palmadora. The description of the new species was made based on morphological and karyotypic analysis. Morphologically, it differs from T. palmadora by the much smaller size, semi-prostrate habit, smaller and deciduous stem-segments, lower density of spines, slightly larger and wide-open flowers, smooth pericarpel, and the globose to obovoid, purplish ripe fruit. The karyotype of T. mirim differs from T. palmadora in being tetraploid (not diploid), by presenting chromosomes that are twice as large, eight of which are submetacentric (differing from the fully metacentric standard karyotype of T. palmadora). The distribution of the new species is associated with the Caatinga of the crystalline basement of the northwestern hinterland of Ceará, found at relatively low altitudes (190-360 m). The IUCN category of threat for the new taxon was preliminary assessed. Both EOO and AOO indicate that the species is endangered (EN-B1-2ab). cactus Cactaceae (Cactaceae Opuntioideae, Opuntioideae , Opuntioideae) illustrated T Ceará Brazil 2009 analysis Morphologically size semiprostrate semi prostrate habit stemsegments, stemsegments stem segments, segments stem-segments spines wideopen wide open flowers pericarpel obovoid fruit not diploid, diploid diploid) large differing . palmadora) 190360 190 360 (190-36 m. m m) assessed ENB12ab. ENB12ab ENBab EN B1 2ab B ab (EN-B1-2ab) 200 19036 19 36 (190-3 ENB (EN-B1-2ab 20 1903 1 3 (190- 2 (190 (19 (1 (

RESUMO Objetivo Estimar a cobertura vacinal da hepatite A em crianças de 24 meses e identificar fatores associados à ausência de vacinação. Métodos Inquérito em amostra estratificada por estratos socioeconômicos em capitais (2020-2022), com estimativa de cobertura e intervalos de confiança de 95% (IC95%) e análise de fatores pela razão de prevalência (RP) via regressão de Poisson. Resultados Nas 31.001 crianças, a cobertura da hepatite A foi de 88,1% (IC95% 86,8;89,2). Nos estratos socioeconômicos (A/B), a variável pais/responsáveis imigrantes foi associada à ausência de vacinação (RP = 1,91; IC95% 1,09;3,37); nos estratos C/D, crianças de cor amarela (RP = 4,69; IC95% 2,30;9,57), 4ª ordem de nascimento ou mais (RP = 1,68; IC95% 1,06;2,66), não frequentar creche/berçário (RP = 1,67; IC95% 1,24;2,24) e mãe com trabalho remunerado (RP = 1,42; IC95% 1,16;1,74) foram associadas à ausência de vacinação. Conclusão Cobertura da hepatite A abaixo da meta (95%), sugerindo-se considerar especificidades dos estratos sociais. 2 20202022, 20202022 2020 2022 , (2020-2022) 95 IC95 IC RP Poisson 31001 31 001 31.00 881 88 1 88,1 (IC95 86,889,2. 868892 86,8 89,2 . 86 8 89 86,8;89,2) A/B, AB A/B B (A/B) paisresponsáveis pais responsáveis 1,91 191 91 1,093,37 109337 1,09 3,37 09 3 37 1,09;3,37) CD C D C/D 4,69 469 4 69 2,309,57, 230957 2,30 9,57 30 9 57 2,30;9,57) ª 1,68 168 68 1,062,66, 106266 1,06 2,66 06 66 1,06;2,66) crecheberçário creche berçário 1,67 167 67 1,242,24 124224 1,24 2,24 1,24;2,24 1,42 142 42 1,161,74 116174 1,16 1,74 16 74 1,16;1,74 95%, (95%) sugerindose sugerindo se sociais 2020202 202 (2020-2022 IC9 3100 00 31.0 88, (IC9 889 86,889,2 86889 868 86, 892 89, 86,8;89,2 (A/B 1,9 19 093 1,093,3 10933 109 1,0 337 3,3 0 1,09;3,37 4,6 46 6 309 2,309,57 23095 230 2,3 957 9,5 5 2,30;9,57 1,6 062 1,062,66 10626 106 266 2,6 1,06;2,66 242 1,242,2 12422 124 1,2 224 2,2 1,24;2,2 1,4 14 161 1,161,7 11617 116 1,1 174 1,7 7 1,16;1,7 (95% 202020 20 (2020-202 310 31. (IC 86,889, 8688 86,8;89, 1, 1,093, 1093 10 33 3, 1,09;3,3 4, 2,309,5 2309 23 2, 9, 2,30;9,5 1,062,6 1062 26 1,06;2,6 1,242, 1242 12 22 1,24;2, 1,161, 1161 11 17 1,16;1, (95 20202 (2020-20 86,889 86,8;89 1,093 1,09;3, 2,309, 2,30;9, 1,062, 1,06;2, 1,242 1,24;2 1,161 1,16;1 (9 (2020-2 86,88 86,8;8 1,09;3 2,309 2,30;9 1,062 1,06;2 1,24; 1,16; ( (2020- 86,8; 1,09; 2,30; 1,06; (2020 (202 (20 (2

ABSTRACT Objective To estimate hepatitis A vaccination coverage in 24-month-old children and identify factors associated with non-vaccination. Methods This was a survey involving a sample stratified by socioeconomic strata in capital cities (2020-2022), with coverage estimates and 95% confidence intervals (95%CI), the factor analysis was performed using the prevalence ratio (PR) by means of Poisson regression. Results Among 31,001 children, hepatitis A coverage was 88.1% (95%CI 86.8;89.2). Regarding socioeconomic strata (A/B), the variable immigrant parents/guardians was associated with non-vaccination (PR = 1.91; 95%CI 1.09;3.37); in strata C/D, children of Asian race/skin color (PR = 4.69; 95%CI 2.30;9.57), fourth-born child or later (PR = 1.68; 95%CI 1.06;2 .66), not attending daycare/nursery (PR = 1.67; 95%CI 1.24;2.24) and mother with paid work (PR = 1.42; 95%CI 1.16;1.74) were associated with non-vaccination. Conclusion Hepatitis A coverage was below the target (95%), suggesting that specificities of social strata should be taken into consideration. 24monthold monthold 24 month old nonvaccination. nonvaccination non vaccination. 20202022, 20202022 2020 2022 , (2020-2022) 95 95%CI, 95CI CI (95%CI) PR regression 31001 31 001 31,00 881 88 1 88.1 86.889.2. 868892 86.8 89.2 . 86 8 89 2 86.8;89.2) A/B, AB A/B B (A/B) parentsguardians parents guardians 1.91 191 91 1.093.37 109337 1.09 3.37 09 3 37 1.09;3.37) CD C D C/D raceskin race skin 4.69 469 4 69 2.309.57, 230957 2.30 9.57 30 9 57 2.30;9.57) fourthborn fourth born 1.68 168 68 1.062 1062 1.06 06 1.06; .66, 66 .66 .66) daycarenursery daycare nursery 1.67 167 67 1.242.24 124224 1.24 2.24 1.24;2.24 1.42 142 42 1.161.74 116174 1.16 1.74 16 74 1.16;1.74 95%, (95%) consideration 2020202 202 (2020-2022 3100 00 31,0 88. 889 86.889.2 86889 868 86. 892 89. 86.8;89.2 (A/B 1.9 19 093 1.093.3 10933 109 1.0 337 3.3 0 1.09;3.37 4.6 46 6 309 2.309.57 23095 230 2.3 957 9.5 5 2.30;9.57 1.6 062 106 .6 242 1.242.2 12422 124 1.2 224 2.2 1.24;2.2 1.4 14 161 1.161.7 11617 116 1.1 174 1.7 7 1.16;1.7 (95% 202020 20 (2020-202 310 31, 86.889. 8688 86.8;89. 1. 1.093. 1093 10 33 3. 1.09;3.3 4. 2.309.5 2309 23 2. 9. 2.30;9.5 1.242. 1242 12 22 1.24;2. 1.161. 1161 11 17 1.16;1. (95 20202 (2020-20 86.889 86.8;89 1.093 1.09;3. 2.309. 2.30;9. 1.242 1.24;2 1.161 1.16;1 (9 (2020-2 86.88 86.8;8 1.09;3 2.309 2.30;9 1.24; 1.16; ( (2020- 86.8; 1.09; 2.30; (2020 (202 (20 (2

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The effect of ammonium bicarbonate (AB) and polyethylene wax (PW) on the physicochemical properties of macroporous biphasic calcium phosphate bioceramics (BCPs) processed by space-holder technique was investigated. BCP powder was mixed with AB and PW and, then, uniaxially cold-pressed at 300 MPa. AB and PW were eliminated by heat treatment at 170°C for 2 hours or 550°C for 4 hours, respectively. Subsequently, the samples were air-sintered at 1070ºC for 2 hours. The results revealed that AB is more attractive than PW due to its lower degradation temperature, which has avoided the formation of undesirable phases. In addition, it favored an adequate consolidation of the particles with the formation of sintering necks that provided a better mechanical resistance to handling. The samples with AB also presented the formation of uniformly distributed macro and microporosity in great extension, which is shown by literature as a fundamental combination to stimulate cells/scaffold interaction. (AB (PW BCPs (BCPs spaceholder space holder investigated then coldpressed cold pressed 30 MPa 170C C 170 550C 550 respectively Subsequently airsintered air sintered ºC temperature phases addition handling extension cellsscaffold cells scaffold interaction 3 17 55 1 5

ABSTRACT Objective To analyze factors associated with full vaccination coverage with valid doses, in children from four state capitals and three other cities in Southeast Brazil. Method Analysis of a population survey conducted in 2020-2021, with a sample stratified according to socioeconomic levels of children born in 2017-2018, with data collected through photographic records of their vaccination cards. Odds ratios (OR) and 95% confidence intervals (95%CI) for full vaccination coverage were estimated based on the characteristics of the family, mother and child. Results Among 8703 children, lowest coverage occurred in strata A and B (OR=0.39; 95%CI 0.23;0.67 and OR=0.38; 95%CI 0.25;0.58); in consumption level A/B (OR=0.38; 95CI% 0.28;0.52); among those with income >BRL8000/month (OR=0.23; 95%CI 0.12;0.42); in children of mothers with higher education (OR=0.47; 95%CI 0.32;0.71); in children not vaccinated exclusively in the public service (OR=0.37; 95%CI 0.26;0.51) and in children with a vaccination delay of up to 6 months (OR=0.28; 95%CI 0.22;0.37). Conclusion Coverage did not reach the targets for controlling vaccine-preventable diseases and was negatively associated with higher socioeconomic status.

RESUMO Objetivo Analisar fatores associados à cobertura vacinal completa com doses válidas, em crianças das capitais e em três outras cidades da região sudeste. Métodos Trata-se de análise de inquérito populacional conduzido em 2020-2021, em amostra estratificada segundo níveis socioeconômicos de crianças nascidas em 2017-2018, com dados coletados por registro fotográfico da caderneta de vacinação. Foram estimadas razões de chances (odds ratio, OR) e intervalo de confiança de 95% (IC95%) da cobertura vacinal completa pelas características da família, mãe e criança. Resultados Em 8.703 crianças, menor cobertura ocorreu nos estratos A e B (OR=0,39; IC95% 0,23;0,67 e OR=0,38; IC95% 0,25;0,58); nível de consumo A/B (OR=0,38; IC95% 0,28;0,52); renda mensal inferior a R$ 8.000,00 (OR=0,23; IC95% 0,12;0,42); em filhos de mães com ensino superior (OR=0,47; IC95% 0,32;0,71); em crianças não vacinadas exclusivamente no serviço público (OR=0,37; IC95% 0,26;0,51) e com atraso vacinal até 6 meses (OR=0,28; IC95% 0,22;0,37). Conclusão As coberturas não atingiram metas para controlar doenças imunopreveníveis e associaram-se negativamente ao maior nível socioeconômico.

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Resumo O objetivo da pesquisa foi analisar perícias psicológicas realizadas em cidades do Paraná do ano de 2019 no que tange aos aspectos cognitivos. Para tanto, foram consultados 1009 processos arquivados em clínicas credenciadas ao Departamento de Trânsito do Paraná (DETRAN-Pr). Os resultados, inerentes à caracterização das perícias, apontaram que os participantes com idade média de 27 anos, 44,4% possuindo ensino médio completo, 72,2% para a 1ª habilitação, 61% para a categoria A/B. Foram encontrados 12 tipos de instrumentos de Avaliação Psicológica padronizados. Os resultados apontam desempenho médio nos instrumentos e relação de dependência entre os principais construtos investigados. Considera-se que, além de habilidades cognitivas preservadas, a formação dos condutores desde o ensino básico é importante contribuinte para o trânsito seguro. 201 cognitivos tanto 100 DETRANPr. DETRANPr DETRAN Pr . (DETRAN-Pr) 2 anos 444 44 4 44,4 completo 722 72 72,2 ª habilitação 61 AB A B A/B 1 padronizados investigados Considerase Considera se preservadas seguro 20 10 (DETRAN-Pr 44, 7 72, 6

Abstract The objective of this research was to analyze psychological tests conducted in cities in the state of Paraná in the year 2019, focusing on cognitive aspects. For this purpose, we examined 1009 records from clinics accredited to the State Traffic Department of Paraná (DETRAN-Pr). The results, inherent to the characterization of the expertise, pointed out that the participants had an average age of 27 years, 44.4% had completed secondary education, 72.2% were first-time applicants, and 61% had the A/B category. Twelve types of standardized Psychological Assessment instruments were found. The results indicated that participants exhibited an average performance in these instruments, and there was a significant correlation between the main constructs investigated. These findings suggest that, in addition to maintaining cognitive skills, providing driver education starting from elementary school could significantly contribute to enhancing road safety. 2019 aspects purpose 100 DETRANPr. DETRANPr DETRAN Pr . (DETRAN-Pr) expertise 2 years 444 44 4 44.4 722 72 72.2 firsttime first time applicants 61 AB A B category found investigated skills safety 201 10 (DETRAN-Pr 44. 7 72. 6 20 1

Resumen El objetivo de la investigación fue analizar las pruebas psicológicas realizadas en ciudades de Paraná en el año 2019 sobre aspectos cognitivos. Para ello se consultaron 1009 expedientes archivados en clínicas acreditadas ante el Departamento de Tránsito de Paraná (DETRAN-Pr). Los resultados, inherentes a la caracterización de la especialización, apuntaron que los participantes tenían una edad media de 27 años, 44,4% tenían estudios secundarios completos, 72,2% para el 1º título, 61% para la categoría A/B. Se encontraron doce tipos de instrumentos de Evaluación Psicológica estandarizados. Los resultados muestran un desempeño promedio en los instrumentos y una relación de dependencia entre los principales constructos investigados. Se considera que, además de preservar las habilidades cognitivas, la formación de los conductores desde la escuela primaria en adelante es un importante contribuyente a la seguridad del tráfico. 201 cognitivos 100 DETRANPr. DETRANPr DETRAN Pr . (DETRAN-Pr) especialización 2 años 444 44 4 44,4 completos 722 72 72,2 º título 61 AB A B A/B estandarizados investigados cognitivas tráfico 20 10 (DETRAN-Pr 44, 7 72, 6 1

RESUMO No interior da região semiárida brasileira (bioma Caatinga), há ocorrência de refúgios de vegetação de outros biomas que se apresentam principalmente em topos de formações geológicas do período Pré-Cambriano, como a Chapada do Araripe. Este trabalho objetivou o conhecimento da estrutura, diversidade e similaridade florística de um fragmento de mata úmida na Chapada do Araripe, sul do Ceará (708m Alt.), visando subsidiar estratégias de conservação dessa comunidade, área de relevante valor ecológico, cultural e paisagístico. Em 13 parcelas de 25x25m (0,8 ha), foram inventariados todos os indivíduos com DAP ≥ 5cm, observando-se altura total. A similaridade florística foi observada pelo método de Jaccard a partir da comparação com outras sete áreas em diferentes regiões do Brasil. Foram encontradas 66 espécies distribuídas em 34 famílias, num total de 1.544 indivíduos com DA=1.997,30 ind.ha-1 e AB=32,618 m²ha-1. Fabaceae (25,75%) e Myrtaceae (6%) apresentaram maior número de espécies e Brosimum gaudichaudii apresentou maior IVI. O índice de Shannon (H’) foi 3,13 e a equabilidade de Pielou (J’) foi 0,75. A diversidade beta, comparada com outras áreas de mata úmida (core e disjuntas), foi considerada alta e a estatística apontou maior similaridade com área da mesorregião da mata pernambucana. Os resultados permitem caracterizar a área como refúgio vegetacional de mata úmida, corroborando com a teoria dos refúgios e evidenciam forte penetração de espécies savânicas (cerradão, cerrado, caatinga/carrasco) enfatizando a atuação de impulsos climáticos ocorridos no Quaternário e apontando para a necessidade de estratégias de conservação devido ao antropismo acelerado. bioma Caatinga, Caatinga , Caatinga) PréCambriano, PréCambriano Pré Cambriano, Cambriano Pré-Cambriano Araripe estrutura 708m m Alt., Alt Alt. Alt.) comunidade ecológico paisagístico 1 xm x 0,8 08 0 8 (0, ha, ha ha) 5cm cm observandose observando Brasil 6 3 famílias 1544 544 1.54 DA199730 DA 997 30 DA=1.997,3 ind.ha1 indha1 indha ind.ha ind ind.ha- AB32618 AB 32 618 AB=32,61 m²ha1. m²ha1 mha m²ha 1. m²ha-1 25,75% 2575 25 75 (25,75% 6% (6% IVI H (H’ 313 3,1 J (J’ 075 0,75 beta core disjuntas, disjuntas disjuntas) pernambucana cerradão, cerradão (cerradão cerrado caatinga/carrasco caatingacarrasco caatinga carrasco acelerado 0, (0 154 54 1.5 DA19973 99 DA=1.997, ha1 AB3261 61 AB=32,6 m²ha- 25,75 257 2 7 (25,75 (6 (H 31 3, (J 07 0,7 ( 15 5 DA1997 9 DA=1.997 AB326 AB=32, 25,7 (25,7 DA199 DA=1.99 AB32 AB=32 25, (25, DA19 DA=1.9 AB3 AB=3 (25 DA1 DA=1. AB= (2 DA=1 DA=

ABSTRACT Inside the Brazilian semi-arid region (Caatinga biome) there are vegetation refuges from other biomes that are present mainly at greater elevations in ancient geological formations such as Chapada do Araripe. This study aimed to understand the structure, diversity and floristic similarity of a fragment of humid forest in order to support conservation strategies for this community in Chapada do Araripe, southern Ceará (708m Alt.), an area of relevant ecological, cultural and scenic value. In 13 parcels of 25x25m (0.8 ha) all individuals with DBH ≥ 5cm were inventoried, observing total height. Floristic similarity was observed using the Jaccard method, comparing it with seven other areas in different regions of the Brazil. Sixty-six species were found distributed in 34 families, in a total of 1,544 individuals with DA=1,997.30 ind.ha-1 and AB =32,618 m²ha-1. Fabaceae (25.75%) and Myrtaceae (6%) had the highest number of species and Brosimum gaudichaudii had the highest IVI. The Shannon index (H') was 3.13 and the Pielou equability (J') was 0.75. The beta diversity, compared with other areas of humid forest (core and disjunct), was considered high and the statistics showed greater similarity with the area of the mesoregion of Pernambuco forest. The results allow the characterization of the area as a vegetational refuge of humid forest, corroborating the Refuge Theory and showing strong penetration of savanna species (“Cerradão”, Cerrado, Caatinga/“Carrasco”), emphasizing the action of climatic impulses that occurred in the Quaternary and pointing to the need to conservation strategies due to accelerated anthropism. semiarid semi arid Caatinga biome Araripe structure 708m m Alt., Alt Alt. , Alt.) ecological value 1 xm x 0.8 08 0 8 (0. ha cm inventoried height method Brazil Sixtysix Sixty six 3 families 1544 544 1,54 DA199730 DA 997 30 DA=1,997.3 ind.ha1 indha1 indha ind.ha ind ind.ha- 32618 32 618 =32,61 m²ha1. m²ha1 mha m²ha 1. m²ha-1 25.75% 2575 25 75 (25.75% 6% 6 (6% IVI H (H' 313 3.1 J (J' 075 0.75 core disjunct, disjunct disjunct) Cerradão, Cerradão (“Cerradão” Cerrado Caatinga/Carrasco, CaatingaCarrasco Caatinga/ Carrasco Caatinga/“Carrasco”) anthropism 0. (0 154 54 1,5 DA19973 99 DA=1,997. ha1 3261 61 =32,6 m²ha- 25.75 257 2 7 (25.75 (6 (H 31 3. (J 07 0.7 (“Cerradão Caatinga/Carrasco Caatinga/“Carrasco” ( 15 5 1, DA1997 9 DA=1,997 326 =32, 25.7 (25.7 Caatinga/“Carrasco DA199 DA=1,99 =32 25. (25. DA19 DA=1,9 =3 (25 DA1 DA=1, = (2 DA=1 DA=

Resumo O objetivo foi verificar a evolução da implementação do Núcleo Ampliado de Saúde da Família e Atenção Básica (NASF-AB) nos municípios da região Sul do Brasil, de 2008 a 2019, sob à luz da hipótese da equidade inversa. Estudo ecológico considerando 1.188 municípios do Sul do Brasil. As análises foram separadas por estado, com os municípios divididos em quartis de Índice de Desenvolvimento Humano Municipal - Renda. Foi calculado o percentual acumulativo de implementação do NASF-AB no período e a desigualdade entre Q1 (mais rico) e Q4 (mais pobre) verificada por medidas de desigualdade absoluta e relativa. No Paraná o Q1 apresentou maior cobertura do NASF-AB do que o Q4 e, apesar da desigualdade ter reduzido ao final do período, ainda estava bem demarcada, seguindo padrão “top inequality”. Em Santa Catarina ocorreu o que prevê a hipótese, com aumento das desigualdades no início e posterior redução quando já existia NASF-AB em cerca de 90% dos municípios do Q1, caracterizando “botton inequality”. No Rio Grande do Sul a hipótese foi refutada ao observar, a partir de 2014, maior implementação no Q4 em relação ao Q1. NASFAB NASF AB (NASF-AB Brasil 200 2019 inversa 1188 1 188 1.18 estado Renda Q mais rico pobre relativa demarcada top inequality. inequality . inequality” 90 botton observar 2014 20 201 118 18 1.1 9 2 11 1.

Abstract The present study aimed to analyze the evolution of the implementation of Family Health and Primary Health Care Expanded Support Centers (NASF-AB, in Portuguese) in the municipalities of Southern Brazil, from 2008 to 2019, in light of the inverse equity hypothesis. This was an ecological study, considering 1,188 municipalities of Southern Brazil. The analyses were separated by state, with municipalities divided into quartiles of Municipal Human Development Index - Income (MHDI-Income). Our study calculated the cumulative percentage of the implementation of NASF-AB within the given period and the inequality between Q1 (richest) and Q4 (poorest), assessed by the absolute and relative inequality measures. In Paraná, Q1 presented a higher coverage of NASF-AB than did Q4, and, although the inequality had decreased at the end of the period, it was still quite distinct, according to the “top inequality” pattern. In Santa Catarina, the predictions of the hypothesis were confirmed, with inequalities found in the beginning of the period and a near 90% decline once NASF-AB had been implemented in the municipalities of Q1, characterizing the “bottom inequality” pattern. In Rio Grande do Sul, the hypothesis was refuted observing that since 2014 there was a greater implementation in Q4 as compared to Q1 was observed. NASFAB, NASFAB NASF AB, AB (NASF-AB Portuguese Brazil 200 2019 1188 1 188 1,18 state MHDIIncome. MHDIIncome MHDI . (MHDI-Income) Q richest (richest poorest, poorest , (poorest) measures Paraná distinct top pattern Catarina confirmed 90 bottom Sul 201 observed 20 118 18 1,1 (MHDI-Income (poorest 9 2 11 1,