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RESUMO: O ensino de anatomia vem se modificando ao longo dos anos, introduzindo métodos tecnológicos, principalmente após o período pandêmico. Questiona-se o uso exclusivo da tecnologia em comparação aos métodos tradicionais de dissecação e aulas teóricas presenciais no que diz respeito à aquisição de conhecimento. Este artigo analisou a percepção de conhecimento de alunos de diversos semestres do curso de Medicina Veterinária, comparando alunos que tiveram aulas apenas online com aqueles que tiveram aulas presenciais de Anatomia Descritiva dos Animais Domésticos. Para tanto, questões foram enviadas por meio de formulário, com preenchimento voluntário e anônimo, e posteriormente analisadas estatisticamente. Os resultados indicam que 11,5% dos alunos que cursaram a disciplina remotamente falharam na aplicação dos conhecimentos em outras disciplinas, enquanto nenhum aluno do ensino presencial relatou o mesmo. A maioria dos alunos, tanto dos grupos remotos quanto dos presenciais, lembram-se do assunto, mas revisam o conteúdo com frequência. Em relação ao conhecimento teórico, o grupo online (80,8%) compreendeu melhor à medida que o curso avançava, comparado a 59,6% do grupo presencial. A ligação entre Anatomia e outras disciplinas foi mais destacada pelo grupo presencial (30,8%) em comparação ao online (15,4%). Ambos os grupos concordam que o contacto físico com peças anatômicas é essencial, mas alguns consideram possível ter um primeiro contacto com imagens ou fotografias 3D. Baseado nesse estudo preliminar, conclui-se que as interações iniciais com a área de Anatomia devem incluir técnicas pedagógicas diversificadas com comunicação empática. A utilização de recursos tecnológicos modernos é um aliado do processo de ensino-aprendizagem, e após a abstração dos conteúdos é possível o uso singular da tecnologia na manutenção e atualização do conhecimento anatômico. RESUMO anos pandêmico Questionase Questiona Veterinária Domésticos formulário anônimo estatisticamente 115 11 5 11,5 mesmo lembramse lembram assunto frequência teórico 80,8% 808 80 8 (80,8% avançava 596 59 6 59,6 30,8% 308 30 (30,8% 15,4%. 154 15,4% . 15 4 (15,4%) essencial 3D D preliminar concluise conclui empática ensinoaprendizagem, ensinoaprendizagem aprendizagem, aprendizagem ensino-aprendizagem anatômico 1 11, 80,8 (80,8 59, 30,8 3 (30,8 15,4 (15,4% 80, (80, 30, (30, 15, (15,4 (80 (30 (15, (8 (3 (15 ( (1

ABSTRACT: Anatomy teaching has been changing over the years, introducing technological methods especially after the pandemic period. An ongoing debate revolves around whether exclusive reliance on technology for anatomy classes, as opposed to traditional methods and face-to-face instruction, enhances knowledge acquisition. This study analyzed the knowledge perception of students from various semesters throughout the Veterinary Medicine course, comparing students who only had online classes with those who had face-to-face classes in Gross Anatomy of Domestic Animals. For this purpose, a questionnaire was distributed for voluntary and anonymous completion, and the responses were subsequently analyzed statistically. The results indicated that 11.5% of the students who took Anatomy remotely failed to apply the knowledge in other subjects, while no face-to-face learning student reported the same. Most students, both remote and face-to-face groups, remember the subject but review the content frequently. Regarding theoretical knowledge, the online group (80.8%) understood better as the course progressed, compared to 59.6% of the face-to-face group. The connection between Anatomy and other subjects was more highlighted by the face-to-face group (30.8%) compared to the online group (15.4%). Both groups agree that physical contact with anatomical specimens is essential; however, some believe that initial exposure through 3D images or photographs is feasible. We concluded based on this preliminary study that the initial interactions with the Anatomy field should include diversified pedagogical techniques with empathetic communication. The use of modern technological resources are allies in the teaching-learning process. Furthermore, after abstracting the contents, technology alone can effectively maintain and update anatomical knowledge. ABSTRACT years period facetoface face instruction acquisition Animals purpose completion statistically 115 11 5 11.5 same frequently 80.8% 808 80 8 (80.8% progressed 596 59 6 59.6 30.8% 308 30 (30.8% 15.4%. 154 15.4% . 15 4 (15.4%) essential however D feasible communication teachinglearning process Furthermore contents 1 11. 80.8 (80.8 59. 30.8 3 (30.8 15.4 (15.4% 80. (80. 30. (30. 15. (15.4 (80 (30 (15. (8 (3 (15 ( (1

https://doi.org/10.1590/0103-8478cr20240214

Evidence syntheses to support decision-making related to the Covid-19 pandemic
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Andrade, Keitty Regina Cordeiro de

; Carvalho, Viviane Karoline da Silva

; Silva, Roberta Borges

; Luquine Junior, Cézar D.

; Farinasso, Cecília Menezes

; Oliveira, Cintia de Freitas

; Mascarenhas, Fabiana

; Paula, Gabriel Antônio Rezende de

; Toledo, Isabela Porto de

; Marinho, Marina Arruda Melo

; Wachira, Virginia Kagure

; Siqueira, Alessandra de Sá Earp

; Araújo, Denizar Vianna

; Sachetti, Camile Giaretta

; Rêgo, Daniela Fortunato

Revista de Saúde Pública

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2024, Volume 58 elocation 16

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO A pandemia de covid-19 gerou um numeroso volume de produções científicas com diferentes níveis de qualidade. A velocidade com que o conhecimento era produzido e compartilhado a nível mundial impôs à gestão em saúde o desafio de buscar meios de identificar as melhores evidências disponíveis para subsidiar suas decisões. Em resposta a este desafio, o Departamento de Ciência e Tecnologia do Ministério da Saúde do Brasil estabeleceu um serviço para elaborar e disponibilizar conhecimento científico abordando questões prioritárias de saúde pública no cenário da pandemia. Entre os temas abordados estão tratamentos medicamentosos, medidas não farmacológicas, testagem, reinfecção e resposta imunológica, imunização, fisiopatologia, síndrome pós-covid e eventos adversos. Neste artigo, discute-se os pontos fortes e lições aprendidas, bem como os desafios e perspectivas que fornecem um exemplo real sobre como disponibilizar as melhores evidências científicas, em tempo hábil e de forma oportuna, para auxiliar o processo decisório durante uma emergência em saúde pública.

ABSTRACT The COVID-19 pandemic generated a large volume of scientific productions with different quality levels. The speed with which knowledge was produced and shared worldwide imposed on health management the challenge of seeking ways to identify the best available evidence to support its decisions. In response to this challenge, the Department of Science and Technology of the Brazilian Ministry of Health started offering a service to produce and provide scientific knowledge addressing priority public health issues in the pandemic scenario. Drug treatments, non-pharmacological measures, testing, reinfection and immunological response, immunization, pathophysiology, post-COVID syndrome and adverse events are among the topics covered. In this article, we discuss the strengths and lessons learned, as well as the challenges and perspectives that present a real example of how to offer the best scientific evidence in a timely manner in order to assist the decision-making process during a public health emergency.

https://doi.org/10.11606/s1518-8787.2024058005226

Gestão e planejamento integrado em saúde no SUS: análise da capacidade governamental em região de saúde da Bahia
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Oliveira, Josilene Silva

; Santos, Adriano Maia dos

; Santos, Hebert Luan P. Campos dos

; Afonso, Gabriela Vital

; Biscarde, Daniela Gomes dos Santos

; Santos, Thadeu Borges Souza

; Prado, Nília Maria de Brito Lima

Physis: Revista de Saúde Coletiva

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2024, Volume 34 elocation e34052

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Este artigo objetivou analisar o grau de implantação do planejamento regional, considerando como condição traçadora os fluxos assistenciais para o câncer de colo de útero, em uma região de saúde do SUS baiano. Trata-se de um estudo avaliativo, do tipo avaliação da implantação do planejamento regionalizado em saúde, a partir de um estudo de caso da Região de Saúde de Vitória da Conquista (RSVC), Bahia. Realizaram-se 29 entrevistas com gestores e representantes da Comissão Intergestores Regional (CIR) e foram analisados 103 documentos. A matriz avaliativa subsidiou a mensuração do grau de implantação do planejamento pelos municípios, considerada incipiente, com três municípios apresentando grau intermediário (M1, M2 e M3); apenas M4 atingiu o grau avançado. Observou-se o caráter político nas tomadas de decisão persistente, preterindo-se a análise técnica e, consequentemente, não favorecendo as ações de monitoramento do acesso, que foram pontuais, e reduzindo a capacidade de controle e negociação junto aos prestadores de serviços privados. Os desafios da gestão, organização sistêmica e contexto político regional foram determinantes para a incipiente implantação do planejamento ante a incoerência entre instituições e características desfavoráveis à integração intermunicipal, sendo necessárias ações estratégicas para fortalecer a capacidade de planejamento integrado entre municípios.

Abstract This article aimed to analyze the degree of implementation of regional planning, considering care flows for cervical cancer as a defining condition, in a health region of the SUS in Bahia. This is an evaluative study, evaluating the implementation of regionalized health planning, based on a case study of the Vitória da Conquista Health Region (RSVC), state of Bahia. Twenty-nine interviews were carried out with managers and representatives of the Regional Intermanagers Commission (CIR) and 103 documents were analyzed. The evaluation matrix supported the measurement of the level of planning implementation by the municipalities, considered incipient, with three municipalities showing an intermediate level (M1, M2, and M3); only M4 reached an advanced grade. The political nature of persistent decision-making was observed, neglecting technical analysis and, consequently, not favoring access monitoring actions, which were punctual, and reducing the capacity for control and negotiation with private service providers. The challenges of management, systemic organization, and regional political context were decisive for the incipient implementation of planning given the incoherence between institutions and characteristics unfavorable to inter-municipal integration, making strategic actions necessary to strengthen the capacity for integrated planning between municipalities.

https://doi.org/10.1590/s0103-7331202434052pt

Food environment of bus terminals in the Rio de Janeiro metropolitan region
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Jesus, Ana Carolina Castro de

; Botelho, Laís Vargas

; Canella, Daniela Silva

; Tavares, Letícia Ferreira

; Castro Junior, Paulo César Pereira de

; Silva, Isabela da Costa Gaspar da

; Cardoso, Letícia de Oliveira

Revista de Saúde Pública

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2024, Volume 58 elocation 04

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO OBJETIVO Descrever e analisar a saudabilidade dos estabelecimentos com venda formal e informal de alimentos em terminais rodoviários da região metropolitana do Rio de Janeiro. MÉTODOS Realizou-se auditoria em 156 estabelecimentos formais e 127 pontos informais de venda de alimentos localizados em 14 terminais rodoviários das cinco cidades mais populosas da região metropolitana do Rio de Janeiro. Foram calculadas proporções de tipos de estabelecimentos e médias (IC95%) de indicadores de disponibilidade de alimentos nos ambientes formal e informal. Para o ambiente formal, foram descritos preços, proporções das formas de pagamento aceitas, dias e horários de funcionamento e categorias de alimentos com propaganda exposta. RESULTADOS A saudabilidade dos pontos de venda de alimentos nos terminais rodoviários era baixa (inferior a 36%). Em média, estavam disponíveis para compra 250% mais subgrupos de alimentos ultraprocessados do que in natura ou minimamente processados. Adquirir comida nesses locais era conveniente porque diversas formas de pagamento estavam disponíveis e os horários de funcionamento dos estabelecimentos acompanhavam os picos de movimentação. Além disso, 73,3% das propagandas se referiam a bebidas ultraprocessadas e o custo-benefício da compra de alimentos ultraprocessados era melhor que o de alimentos in natura ou minimamente processados. CONCLUSÃO O ambiente alimentar dos terminais rodoviários da região metropolitana do Rio de Janeiro promove uma alimentação não saudável. Políticas públicas de regulação devem se concentrar em iniciativas que limitem a ampla disponibilidade e publicidade de alimentos ultraprocessados nesses espaços de grande circulação de pessoas.

ABSTRACT PURPOSE To describe and analyze the healthiness of formal and informal food establishments in bus terminals of the metropolitan region of the state of Rio de Janeiro. METHOD An audit was conducted in 156 formal and 127 informal food establishments located in 14 bus terminals of the five most populous cities of the metropolitan region of Rio de Janeiro. Proportions of types of establishments and means (95%CI) of food availability indicators in formal and informal settings were calculated. For the formal setting, prices, proportions of accepted payment methods, days and hours of operation, and food categories with displayed advertising were described. RESULTS The healthiness of food establishments in bus terminals was low (less than 36%). On average, ultra-processed food subgroups were 250% more available for purchase than fresh or minimally processed food. Purchasing food at these places was convenient because several forms of payment were available, and the opening hours of the establishments followed the peaks of movement. In addition, 73.3% of the advertising referred to ultra-processed drinks, and the cost-benefit of buying ultra-processed food was better than fresh or minimally processed food. CONCLUSION The food environment of bus terminals in the metropolitan region of Rio de Janeiro promotes unhealthy eating. Regulatory public policies should focus on initiatives to limit the wide availability and advertising of ultra-processed food in spaces of great circulation of people.

https://doi.org/10.11606/s1518-8787.2024058004769

Food environment of bus terminals in the Rio de Janeiro metropolitan region
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Jesus, Ana Carolina Castro de

; Botelho, Laís Vargas

; Canella, Daniela Silva

; Tavares, Letícia Ferreira

; Castro Junior, Paulo César Pereira de

; Silva, Isabela da Costa Gaspar da

; Cardoso, Letícia de Oliveira

Revista de Saúde Pública

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2024, Volume 58 elocation 04

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.11606/s1518-8787.2024058004769

Influence of Teas on Phospholipase A2 and Protease Activity in the Context of Blood Hemostasis-Related Processes A HemostasisRelated Hemostasis Related
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Carapiá, Mateus Santos

; Oliveira, Daniela Aparecida

; Trento, Marcus Vinicius Cardoso

; Marcussi, Silvana

; Abreu, Tatiane Silva de

; Cesar, Pedro Henrique Souza

; Braga, Mariana Aparecida

Brazilian Archives of Biology and Technology

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2024, Volume 67 elocation e24220661

Abstract: En | Text: En | PDF: En

Abstract Tea is identified as the second most consumed drink in the world, and its frequent intake is related to several benefits to human health, considering its antimutagenic, anticarcinogenic, antimicrobial, anti-inflammatory, antihistamine, diuretic, calming, and above all, antioxidant effects. These effects are often associated with the action of the phenolic compounds contained in these infusions. In Brazil, among the most consumed infusions are the teas of chamomile (Matricaria chamomilla L.), lemongrass (Cymbopogon citratus (D.C.) Stapf), lemon balm (Melissa officinalis L.), anise (Pimpinella anisum L.), yerba mate (Ilex paraguariensis A. St.-Hil), peppermint (Mentha piperita L.), and green/black tea (Camellia sinensis L.). Therefore, said popularity is the reason why the mentioned species were chosen to be evaluated on inflammatory enzymes. The activity of phospholipases A2 was reduced by more than 25% after treatment with black tea and yerba mate. The most significant inhibition of protease activity was observed after incubation with black tea (40.74%), green tea (31.48%) and yerba mate (25.93%). Infusions of black and green tea reduced hemolysis in semisolid and liquid media, and for the latter, reductions of up to 50% of hemolytic activity were observed, indicating an anti-inflammatory potential of the samples. Plasma incubations with green tea, black tea and lemon balm and subsequent addition of venom (1:10 ratio; tea:PBS, v:v) prolonged the coagulation time of citrated plasma by approximately twice compared to the positive control. All controls with pure tea had a thrombolytic character, in higher proportions than the venom control, especially chamomile (273.55% dissolution). Phenolic compounds derived from phenolic acids, flavonoids, and tannins are identified as the main agents that promote the biological effects observed in this study. This is mainly due to their anti-catalytic properties exerted on inflammatory enzymes and as chelating agents of enzymatic co-factors. The evaluated teas showed potential for nutraceutical use, thus pointing to the possibility of use as an adjuvant in the treatment of diseases linked to hemostasis. world health antimutagenic anticarcinogenic antimicrobial antiinflammatory, antiinflammatory anti inflammatory, antihistamine diuretic calming all Brazil Matricaria L., L L. , L.) Cymbopogon D.C. DC D C (D.C. Stapf, Stapf Stapf) Melissa Pimpinella Ilex A St.Hil, StHil St. Hil St St.-Hil) Mentha greenblack Camellia L.. . Therefore 25 40.74%, 4074 40.74% 40 74 (40.74%) 31.48% 3148 31 48 (31.48% 25.93%. 2593 25.93% 93 (25.93%) media latter 50 samples 110 1 10 (1:1 ratio teaPBS, teaPBS PBS, PBS tea:PBS vv v v:v control character 273.55% 27355 273 55 (273.55 dissolution. dissolution dissolution) acids flavonoids study anticatalytic catalytic cofactors. cofactors co factors. factors co-factors hemostasis D.C (D.C St.Hil St.-Hil 2 407 40.74 4 7 (40.74% 31.48 314 3 (31.48 259 25.93 9 (25.93% 5 11 (1: 273.55 2735 27 (273.5 40.7 (40.74 31.4 (31.4 25.9 (25.93 (1 273.5 (273. 40. (40.7 31. (31. 25. (25.9 ( 273. (273 (40. (31 (25. (27 (40 (3 (25 (2 (4

https://doi.org/10.1590/1678-4324-2024220661

Nutritional characteristics of distillers dried grains with solubles and their effects on performance and economic viability for pigs
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Corassa, Anderson

; Santos, Tatiane Izabel Silva

; Silva, Daniela Rocha

; Straub, Igor Willian Wrobel

; Ton, Ana Paula Silva

; Sbardella, Maicon

; Kiefer, Charles

; Brito, Claudson Oliveira

; Teixeira, Alexandre de Oliveira

Ciência Animal Brasileira

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2024, Volume 25 elocation 77350E

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo As características químicas e nutricionais de quatro grãos secos destilados com solúveis (DDGS) foram determinados quanto a matéria seca (MS), matéria mineral (MM), proteína bruta (PB), extrato etéreo (EE), fibra em detergente neutro (FDN) e energia bruta analisada (EBa) dos quais os valores de energia bruta (EB), digestível (ED), metabolizável (EM) e liquida (EL) foram estimados. Houve diferenças no conteúdo de EE, FDN, EBa, EB, ED, EM e EL entre lotes. Um total de 40 machos castrados 72.69 ± 5.66 kg foram distribuídos em blocos ao caso, alimentados com dietas com 0, 100, 200 e 300 g kg−1 DDGS por 28 dias. A inclusão de DDGS não afetou consumo de ração diário, ganho de peso diário e conversão alimentar mas reduziu de forma linear o peso final. Baseados nos resultados de desempenho, preços de ingredientes e mercado local foram calculados os custos de ração, receita e lucro operacional bruto (LOB). Inclusões de DDGS em dietas para suínos reduziu custos e receitas mas não afetou LOB. DDGS apresentam variação química e nutricional entre lotes. Níveis de até 300 g kg−1 de DDGS não afetam desempenho e lucratividade com suínos em terminação. (DDGS MS, MS , (MS) MM, MM (MM) PB, PB (PB) EE (EE) FDN (FDN EBa (EBa EB (EB) ED (ED) (EM (EL estimados lotes 4 7269 72 69 72.6 566 5 66 5.6 caso 0 100 20 30 kg1 1 kg− 2 dias final LOB . (LOB) terminação (MS (MM (PB (EE (EB (ED 726 7 6 72. 56 5. 10 3 (LOB

Abstract The chemical and nutritional characteristics of the four distillers dried grains with solubles (DDGS) were determined for dry matter (DM), mineral matter (MM), crude protein (CP), ether extract (EE), neutral detergent fiber (NDF) and gross energy analyzed (GEa), from which the values of gross energy (GE), digestible energy (DE), metabolizable energy (ME) and net energy (NE) were estimated. There were differences in the contents of EE, NDF, GEa, GE, DE, ME and NE between the lots. A total of 40 barrows with an initial weight of 72.69 ± 5.66 kg were assigned to a randomized block design, fed diets containing 0, 100, 200 and 300 g kg−1 DDGS for 28 days and were subjected to performance assessment. The inclusion of DDGS in the diets did not affect daily feed intake (DFI), daily weight gain (DWG) or feed conversion (FC) but linearly reduced the final weight. Based on the results of the performance and prices of ingredients in the local market, we calculated the costs of feed, revenue and gross operating profit (GOP). Inclusions of DDGS in pig diets reduced costs and revenues but did not affect GOP. DDGS presented chemical and nutritional variation between the lots. Levels of inclusion up to 300 g kg−1 DDGS do not affect finishing pig performance and profitability. (DDGS DM, DM , (DM) MM, MM (MM) CP, CP (CP) EE (EE) NDF (NDF GEa (GEa) GE (GE) DE (DE) (ME (NE estimated lots 4 7269 72 69 72.6 566 5 66 5.6 design 0 100 20 30 kg1 1 kg− 2 assessment DFI, DFI (DFI) DWG (DWG FC (FC market GOP . (GOP) profitability (DM (MM (CP (EE (GEa (GE (DE 726 7 6 72. 56 5. 10 3 (DFI (GOP

https://doi.org/10.1590/1809-6891v25e-77350e

Evaluation of cervical posture and smartphone use in young adults
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Fontenele, Ticiana Mesquita de Oliveira

; Rabelo, Lorena Karen Silva Magalhães

; Medeiros, Nylla Kettilla Freitas Diógenes

; Sousa, Natália Roque Maia de

; Mont’Alverne, Daniela Gardano Bucharles

; Abdon, Ana Paula Vasconcellos

Fisioterapia em Movimento

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2024, Volume 37 elocation e37115

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Introdução O smartphone, dispositivo móvel e popular, tornou-se atrativo pela facilidade de utilização e multifuncionalidade. Seu uso prolongado, com flexão anterior do pescoço e movimentos repetitivos dos membros superiores, contribui para sintomas musculoesqueléticos. Objetivo Avaliar as alterações da postura cervical pelo uso do smartphone em adultos, bem como verificar a associação da postura com fatores relacionados à saúde. Métodos Estudo transversal, em duas universidades em Fortaleza, Ceará, Brasil, entre 2018 e 2019. Participaram 769 adultos (>18 anos) que usavam rotineiramente o smartphone. Foram coletadas variáveis socioeconômicas, condições de saúde e uso do smartphone. Realizou-se a avaliação do alinhamento postural da cervical, sendo mensurado o alinhamento vertical da cabeça (AVC) pela fotogrametria, na posição anatômica (baseline) e digitando no smartphone. Resultados A idade média foi de 23 anos (± 6,7), com maior proporção do sexo feminino (72,1 %; n = 559) e média de 7,9h (± 4,4) utilizando o dispositivo. O uso do smartphone gerou anteriorização de cabeça relacionada ao sexo masculino (p < 0,05 pelo ΔAVC), tempo de uso do dispositivo (p < 0,05 pela ΔAVC), incapacidade funcional na região cervical (p < 0,05 pela ΔAVC) e não dormir bem (p = 0,019 pela ΔAVC lado D). Conclusão O uso do smartphone na posição de digitação causa anteriorização de cabeça, estando relacionado ao maior tempo de uso, ao sexo masculino, à disfunção da região cervical e ao sono. popular tornouse tornou se multifuncionalidade prolongado superiores musculoesqueléticos transversal Fortaleza Ceará Brasil 201 2019 76 >18 18 (>1 socioeconômicas Realizouse Realizou AVC (AVC fotogrametria baseline (baseline 2 ± ( 6,7, 67 6,7 , 6 7 6,7) 72,1 721 72 1 (72, % 559 79h h 9h 4,4 44 4 p 005 0 05 0,0 ΔAVC, 0019 019 0,01 D. D . D) sono 20 >1 (> 6, 72, (72 55 4, 00 0, 001 01 > (7 5

Abstract Introduction The smartphone, a popular mobile device, has become attractive because it is easy to use and due to it multifunctionality. Its prolonged use, with anterior flexion of the neck and repetitive movements of the upper limbs, contributes to musculoskeletal symptoms. Objective To evaluate changes in cervical posture due to smartphone use in adults, as well as verify the association of posture with health-related factors. Methods Cross-sectional study, carried out at two universities in Fortaleza, Ceará, Brasil, between 2018 and 2019. A total of 769 adults (>18 years old) who routinely used smartphones participated. Data on socioeconomic variables, health conditions and smartphone use were collected. The cervical postural alignment was assessed, with the vertical head alignment (VHA) being measured using photogrammetry, in the anatomical position (baseline) and while typing on the smartphone. Results The mean age was 23 years (± 6.7), with a higher proportion of females (72.1%; n = 559) and an average of 7.9h (± 4.4) using the device. Smartphone use led to the forward head movement related to males (p < 0.05 by ΔVHA), time spent using the device (p < 0.05 by ΔVHA), functional disability in the cervical region (p < 0.05 by ΔVHA) and not sleeping well (p = 0.019 by ΔVHA on the R side). Conclusion Using a smartphone in the typing position causes the head to tilt forward, being related to longer usage time, male gender, cervical region dysfunction and sleep. multifunctionality limbs symptoms healthrelated factors Crosssectional Cross sectional study Fortaleza Ceará Brasil 201 2019 76 >18 18 (>1 old participated variables collected assessed VHA (VHA photogrammetry baseline (baseline 2 ± ( 6.7, 67 6.7 , 6 7 6.7) 72.1% 721 72 1 (72.1% 559 79h h 9h 4.4 44 4 p 005 0 05 0.0 ΔVHA, 0019 019 0.01 side. side . side) gender sleep 20 >1 (> 6. 72.1 (72.1 55 4. 00 0. 001 01 > 72. (72. 5 (72 (7

https://doi.org/10.1590/fm.2024.37115

HOSPITALIZATION, USE OF BIOLOGICS AND SURGERY RATES IN INFLAMMATORY BOWEL DISEASES: A SINGLE-CENTRE COMPARATIVE ANALYSIS BETWEEN PUBLIC AND PRIVATE HEALTHCARE SYSTEMS IN A TERTIARY UNIT FROM LATIN AMERICA HOSPITALIZATION DISEASES SINGLECENTRE SINGLE CENTRE
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ZACHARIAS, Patrícia

; MAGRO, Daniéla Oliveira

; PERUSSOLO, Milena

; BARAÚNA, Fernanda da Silva Barbosa

; KOTZE, Paulo Gustavo

Arquivos de Gastroenterologia

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2024, Volume 61 elocation e23140

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Contexto: As doenças inflamatórias intestinais (DII) têm taxas crescentes de incidência e prevalência em todo o mundo. Na DII, são escassos os estudos comparando as diferenças entre os pacientes de acordo com o nível socioeconômico. Objetivo: Nosso objetivo foi avaliar comparativamente as hospitalizações, o uso de biológicos e as taxas de cirurgia em pacientes com DII entre os sistemas público e privado de saúde. Métodos: Estudo de coorte retrospectivo unicêntrico em pacientes com DII de uma unidade terciária de referência da América Latina, entre 2015 e 2021. Os pacientes com DC (doença de Crohn) e retocolite ulcerativa foram classificados em dois subgrupos: sistema público e privado. Características demográficas, hospitalizações, necessidade de cirurgia e biológicos foram comparadas. Resultados: Foram inclusos 500 pacientes, sendo 322 com DC e 178 com retocolite ulcerativa. Internações por DC foram frequentes em ambos os sistemas de saúde (76,28% na rede privada e 67,46% na rede pública). Mais da metade dos pacientes havia sido submetida a uma ou mais cirurgias abdominais relacionadas à DC, sem diferença significativa entre os subgrupos. Embora não tenha havido diferença nas taxas de uso de terapia biológica nos subgrupos de DC, o infliximabe foi mais utilizado no ambiente público (57,69% vs 43,97%). Não houve diferença nas internações relacionadas a retocolite ulcerativa entre os subgrupos (público 30,69% e privado 37,66%) e nas taxas de colectomia (público: 16,83%, privado: 19,48%). Os biológicos foram prescritos quase duas vezes mais no privado do que no público (45,45 vs 22,77%). Conclusão: Não houve diferença nas taxas de internação hospitalar e de cirurgia abdominal entre os sistemas. Nos pacientes com retocolite ulcerativa, houve maior utilização da terapia biológica no setor privado de saúde. Contexto (DII mundo socioeconômico Objetivo hospitalizações Métodos Latina 201 2021 doença Crohn demográficas comparadas Resultados 50 32 17 76,28% 7628 76 28 (76,28 6746 67 46 67,46 pública. pública . pública) 57,69% 5769 57 69 (57,69 43,97%. 4397 43,97% 43 97 43,97%) 3069 30 30,69 37,66% 3766 37 66 1683 16 83 16,83% 19,48%. 1948 19,48% 19 48 19,48%) 45,45 4545 45 (45,4 22,77%. 2277 22,77% 22 77 22,77%) Conclusão 20 202 5 3 1 76,28 762 7 2 (76,2 674 6 4 67,4 57,69 576 (57,6 439 43,97 9 306 30,6 37,66 376 168 8 16,83 194 19,48 45,4 454 (45, 227 22,77 76,2 (76, 67, 57,6 (57, 43,9 30, 37,6 16,8 19,4 45, (45 22,7 76, (76 57, (57 43, 37, 16, 19, (4 22, (7 (5 (

ABSTRACT Background: Inflammatory bowel diseases (IBD) have rising incidence and prevalence rates globally. In IBD, there are scarce studies comparing differences between patients according to socioeconomic status. Our aim was to comparatively evaluate hospitalizations, use of biologics and rates of surgery in patients with IBD between public and private healthcare systems. Methods: Single-center retrospective cohort study in patients with IBD from a tertiary referral unit from Latin America, between 2015 and 2021. CD and UC patients were classified into two subgroups: public and private systems. Demographic characteristics, hospitalizations, need for surgery and biologics were compared. Results: A total of 500 patients were included, 322 with CD and 178 with UC. CD-related hospitalizations were frequently observed in both healthcare systems (76.28% in private and 67.46% in public). More than half of the patients had been submitted to one or more CD-related abdominal surgery, with no significant difference between the subgroups. Although there was no difference in the rates of use of biological therapy in CD subgroups, infliximab was more used in the public setting (57.69% vs 43.97%). There was no difference in UC-related hospitalizations between the subgroups (public 30.69% and private 37.66%) as well as the rates of colectomy (public: 16.83%, private: 19.48%). Biologics were prescribed almost twice as often in private as compared to public (45.45 vs 22.77%). Conclusion: There were no differences in the rates of hospitalization and abdominal surgery between the systems. In patients with UC, there was greater use of biological therapy in the private healthcare setting. Background (IBD globally status Methods Singlecenter Single center America 201 2021 characteristics Results 50 included 32 17 CDrelated related 76.28% 7628 76 28 (76.28 6746 67 46 67.46 public. . public) 57.69% 5769 57 69 (57.69 43.97%. 4397 43.97% 43 97 43.97%) UCrelated 3069 30 30.69 37.66% 3766 37 66 1683 16 83 16.83% 19.48%. 1948 19.48% 19 48 19.48%) 45.45 4545 45 (45.4 22.77%. 2277 22.77% 22 77 22.77%) Conclusion 20 202 5 3 1 76.28 762 7 2 (76.2 674 6 4 67.4 57.69 576 (57.6 439 43.97 9 306 30.6 37.66 376 168 8 16.83 194 19.48 45.4 454 (45. 227 22.77 76.2 (76. 67. 57.6 (57. 43.9 30. 37.6 16.8 19.4 45. (45 22.7 76. (76 57. (57 43. 37. 16. 19. (4 22. (7 (5 (

https://doi.org/10.1590/s0004-2803.24612023-140

10.

VIABILIDADE DO REÚSO DE RESPIRADORES PFF2 DURANTE A PANDEMIA DA COVID-19 NO BRASIL: ESTUDO QUASE-EXPERIMENTAL PFF COVID19 COVID 19 COVID-1 BRASIL QUASEEXPERIMENTAL QUASE EXPERIMENTAL COVID1 1 COVID-
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Schneider, Daniela Silva dos Santos

; Magalhães, Ana Maria Müller de

; Oliveira, João Lucas Campos de

; Tanaka, Ana Karina Silva da Rocha

Cogitare Enfermagem

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2024, Volume 29 elocation e92105

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

RESUMO Objetivo: Avaliar a viabilidade da descontaminação de respiradores PFF2, em situações de pandemia. Método: Quase-experimento, em hospital público do Sul do Brasil, entre abril e junho de 2021. A amostra foi de respiradores PFF2 usados por seis e 42 horas no centro de terapia intensiva, divididos em grupos (tempo de uso e tipos de intervenção) e grupo controle. Foram avaliados quanto a resistência, integridade e inflamabilidade. Foi utilizada estatística descritiva e inferencial na comparação de múltiplos grupos para verificar se o respirador permanecia seguro para o uso após a descontaminação, entre os diferentes tratamentos e o tempo de uso das máscaras. Resultados: Houve diferença significativa da eficiência do filtro (p=0,002) e da resistência (p<=0,001) entre PFF2. As descontaminações não influenciaram na integridade quando avaliada a sua interação com o tempo de uso. Conclusão: A descontaminação, separadamente ou em conjunto, mostrou-se alternativa viável. Objetivo PFF pandemia Método Quaseexperimento, Quaseexperimento Quase experimento, experimento Quase-experimento Brasil 2021 4 intensiva intervenção controle inflamabilidade máscaras Resultados p=0,002 p0002 p 0 002 (p=0,002 p<=0,001 p0001 001 (p<=0,001 Conclusão conjunto mostrouse mostrou viável 202 p=0,00 p000 00 (p=0,00 p<=0,00 (p<=0,00 20 p=0,0 p00 (p=0,0 p<=0,0 (p<=0,0 2 p=0, p0 (p=0, p<=0, (p<=0, p=0 (p=0 p<=0 (p<=0 p= (p= p<= (p<= (p p< (p<

ABSTRACT Objective: Evaluate the feasibility of decontaminating PFF2 respirators in pandemic situations. Method: Quasi-experiment in a public hospital in South Brazil between April and June 2021. The sample consisted of PFF2 respirators used for six and 42 hours in the intensive care unit, divided into groups (usage time and types of intervention) and a control group. They were evaluated for resistance, integrity, and flammability. Descriptive and inferential statistics were used to compare multiple groups to verify whether the respirator remained safe after decontamination, among the different treatments and the mask usage time. Results: There was a significant difference in filter efficiency (p=0.002) and resistance (p<=0.001) between PFF2. Decontaminations did not influence integrity when their interaction with usage time was evaluated. Conclusion: Decontamination, separately or together, was a viable alternative. Objective PFF situations Method Quasiexperiment Quasi experiment 2021 4 unit intervention group flammability decontamination Results p=0.002 p0002 p 0 002 (p=0.002 p<=0.001 p0001 001 (p<=0.001 Conclusion Decontamination together alternative 202 p=0.00 p000 00 (p=0.00 p<=0.00 (p<=0.00 20 p=0.0 p00 (p=0.0 p<=0.0 (p<=0.0 2 p=0. p0 (p=0. p<=0. (p<=0. p=0 (p=0 p<=0 (p<=0 p= (p= p<= (p<= (p p< (p<

RESUMEN Objetivo: Evaluar la viabilidad de descontaminar los respiradores PFF2 en situaciones pandémicas. Método: Cuasi experimento, en un hospital público del sur de Brasil, entre abril y junio de 2021. La muestra consistió en respiradores PFF2 utilizados durante seis y 42 horas en la unidad de cuidados intensivos, divididos en grupos (tiempo de uso y tipos de intervención) y un grupo de control. Se evaluó su resistencia, integridad e inflamabilidad. Se utilizaron estadísticas descriptivas e inferenciales para comparar varios grupos y comprobar si el respirador seguía siendo seguro de usar tras la descontaminación, entre los distintos tratamientos y el tiempo de uso de las mascarillas. Resultados: Hubo una diferencia significativa en la eficacia del filtro (p=0,002) y la resistencia (p<=0,001) entre los PFF2. La descontaminación no influyó en la integridad cuando se evaluó su interacción con el tiempo de uso. Conclusión: La descontaminación, por separado o en conjunto, demostró ser una alternativa viable. Objetivo PFF pandémicas Método experimento Brasil 2021 4 intensivos intervención control inflamabilidad mascarillas Resultados p=0,002 p0002 p 0 002 (p=0,002 p<=0,001 p0001 001 (p<=0,001 Conclusión conjunto viable 202 p=0,00 p000 00 (p=0,00 p<=0,00 (p<=0,00 20 p=0,0 p00 (p=0,0 p<=0,0 (p<=0,0 2 p=0, p0 (p=0, p<=0, (p<=0, p=0 (p=0 p<=0 (p<=0 p= (p= p<= (p<= (p p< (p<

https://doi.org/10.1590/ce.v29i0.92105

11.

Diretriz de Avaliação Cardiovascular Perioperatória da Sociedade Brasileira de Cardiologia – 2024 202 20 2
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Gualandro, Danielle Menosi

; Fornari, Luciana Savoy

; Caramelli, Bruno

; Abizaid, Alexandre Antonio Cunha

; Gomes, Brenno Rizerio

; Tavares, Caio de Assis Moura

; Fernandes, Caio Julio Cesar dos Santos

; Polanczyk, Carisi Anne

; Jardim, Carlos

; Vieira, Carolina Leticia Zilli

; Pinho, Claudio

; Calderaro, Daniela

; Schreen, Dirk

; Marcondes-Braga, Fabiana Goulart

; Souza, Fábio de

; Cardozo, Francisco Akira Malta

; Tarasoutchi, Flavio

; Carmo, Gabriel Assis Lopes

; Kanhouche, Gabriel

; Lima, José Jayme Galvão de

; Bichuette, Luciana Dornfeld

; Sacilotto, Luciana

; Drager, Luciano Ferreira

; Vacanti, Luciano Janussi

; Gowdak, Luis Henrique Wolff

; Vieira, Marcelo Luiz Campos

; Martins, Marcelo Luiz Floriano Melo

; Lima, Márcio Silva Miguel

; Lottenberg, Marcos Pita

; Aliberti, Márlon Juliano Romero

; Marchi, Mauricio Felippi de Sá

; Paixão, Milena Ribeiro

; Oliveira Junior, Mucio Tavares de

; Yu, Pai Ching

; Cury, Patricia Ramos

; Farsky, Pedro Silvio

; Pessoa, Ranna Santos

; Siciliano, Rinaldo Focaccia

; Accorsi, Tarso Augusto Duenhas

; Correia, Vinícius Machado

; Mathias Junior, Wilson

Arquivos Brasileiros de Cardiologia

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2024, Volume 121 N. 9 elocation e20240590

Abstract: Pt | Text: Pt | PDF: Pt

https://doi.org/10.36660/abc.20240590

12.

Nursing workload and severity of COVID-19 patients in the Intensive Care Unit COVID19 COVID 19 COVID-1 COVID1 1 COVID-
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Santos, Wesley Cajaiba

; Lopes, Maria Carolina Barbosa Teixeira

; Vancini-Campanharo, Cassia Regina

; Boschetti, Daniela

; Dias, Sirlei Oliveira da Silva

; Castro, Meire Cristina Novelli e

; Piacezzi, Luis Humberto Vieri

; Batista, Ruth Ester Assayag

Revista da Escola de Enfermagem da USP

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2024, Volume 58 elocation e20240107

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

RESUMO Objetivos: Avaliar carga de trabalho e gravidade dos pacientes na Unidade de Terapia Intensiva (UTI) com COVID-19. Método: Estudo transversal, analítico realizado na UTI em hospital privado. Incluídos todos os pacientes maiores de 18 anos, com diagnóstico de COVID-19 admitidos de setembro de 2020 a junho de 2021. Carga de trabalho avaliado pelo Nursing Activities Score (NAS), e gravidade pelo Sequential Organ Failure Assessment. Realizado análises descritiva e inferencial. Resultados: Incluídos 217 pacientes, maioria homens, média de idade 62,41 anos, brancos, obesos, não tabagistas e sedentários. A média do NAS foi 84,79. O dimensionamento de pessoal estava em concordância com legislação e NAS. O NAS não foi associado a gravidade. Houve associação da gravidade com maior idade, sexo, comorbidades, sedentarismo, tempo de ventilação mecânica, internação e óbito. Conclusão: A carga de trabalho foi alta e não associada a gravidade e desfechos. A gravidade foi associada às condições demográficas e clínicas. Este estudo mostra a importância do dimensionamento de pessoal, com vistas à promoção da segurança e qualidade assistencial. Objetivos (UTI COVID19. COVID19 COVID 19. 19 Método transversal privado 1 anos COVID-1 202 2021 NAS, , (NAS) Assessment inferencial Resultados 21 homens 6241 62 41 62,4 brancos obesos sedentários 8479 84 79 84,79 sexo comorbidades sedentarismo mecânica óbito Conclusão desfechos clínicas assistencial COVID1 COVID- 20 (NAS 2 624 6 4 62, 847 8 7 84,7 84,

ABSTRACT Objective: To evaluate the workload and severity of patients in the Intensive Care Unit (ICU) with COVID-19. Method: Cross-sectional, analytical study carried out in the ICU of a private hospital. All patients over the age of 18 with a diagnosis of COVID-19 admitted from September 2020 to June 2021 were included. Workload assessed by the Nursing Activities Score (NAS), and severity by the Sequential Organ Failure Assessment. Descriptive and inferential analyses were performed. Results: 217 patients were included, mostly men, mean age 62.41 years, white, obese, non-smokers and sedentary. The average NAS was 84.79. Staffing was in line with legislation and NAS. NAS was not associated with severity. Severity was associated with higher age, gender, comorbidities, sedentary lifestyle, time on mechanical ventilation, hospitalization and death. Conclusion: Workload was high and not associated with severity or outcomes. Severity was associated with demographic and clinical conditions. This study shows the importance of staff sizing, with a view to promoting safety and quality of care. Objective (ICU COVID19. COVID19 COVID 19. 19 Method Crosssectional, Crosssectional Cross sectional, sectional Cross-sectional hospital 1 COVID-1 202 included NAS, , (NAS) Assessment performed Results 21 men 6241 62 41 62.4 years white obese nonsmokers non smokers 8479 84 79 84.79 gender comorbidities lifestyle ventilation death Conclusion outcomes conditions sizing care COVID1 COVID- 20 (NAS 2 624 6 4 62. 847 8 7 84.7 84.

RESUMEN Objetivo: Evaluar la carga de trabajo y la gravedad de los pacientes de la Unidad de Cuidados Intensivos (UCI) con COVID-19. Método: Estudio transversal y analítico realizado en la UCI de un hospital privado. Se incluyeron todos los pacientes mayores de 18 años con diagnóstico de COVID-19 ingresados entre septiembre de 2020 y junio de 2021. Carga de trabajo evaluada mediante la Nursing Activities Score (NAS), y gravedad mediante la valoración secuencial de fallo orgánico. Se realizaron análisis descriptivos e inferenciales. Resultados: Se incluyeron 217 pacientes, en su mayoría hombres, edad media 62,41 años, raza blanca, obesos, no fumadores y sedentarios. El NAS medio era de 84,79. Los niveles de personal se ajustaban a la legislación y al NAS. El NAS no se asoció con la gravedad. La gravedad se asoció a mayor edad, sexo, comorbilidades, sedentarismo, tiempo de ventilación mecánica, hospitalización y muerte. Conclusión: La carga de trabajo fue elevada y no se asoció a la gravedad ni a los resultados. La gravedad se asoció a las condiciones demográficas y clínicas. Este estudio muestra la importancia del dimensionamiento del personal, con vistas a promover la seguridad y la calidad de los cuidados. Objetivo (UCI COVID19. COVID19 COVID 19. 19 Método privado 1 COVID-1 202 2021 NAS, , (NAS) orgánico inferenciales Resultados 21 hombres 6241 62 41 62,4 blanca obesos sedentarios 8479 84 79 84,79 sexo comorbilidades sedentarismo mecánica muerte Conclusión resultados clínicas cuidados COVID1 COVID- 20 (NAS 2 624 6 4 62, 847 8 7 84,7 84,

https://doi.org/10.1590/1980-220x-reeusp-2024-0107en

13.

Evidence syntheses to support decision-making related to the Covid-19 pandemic decisionmaking decision making Covid19 Covid 19 Covid-1 Covid1 1 Covid-
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Andrade, Keitty Regina Cordeiro de

; Carvalho, Viviane Karoline da Silva

; Silva, Roberta Borges

; Luquine Junior, Cézar D.

; Farinasso, Cecília Menezes

; Oliveira, Cintia de Freitas

; Mascarenhas, Fabiana

; Paula, Gabriel Antônio Rezende de

; Toledo, Isabela Porto de

; Marinho, Marina Arruda Melo

; Wachira, Virginia Kagure

; Siqueira, Alessandra de Sá Earp

; Araújo, Denizar Vianna

; Sachetti, Camile Giaretta

; Rêgo, Daniela Fortunato

Revista de Saúde Pública

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2024, Volume 58 elocation 16

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.11606/s1518-8787.2024058005226

14.

Differences in dental care for pregnant women in the public sector after the creation of Previne Brasil
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Soares, Giovanna Mendonça

; Raso, Giovanna Freitas

; Santos, Isadora Custódio Moreira

; Martins, Heron Ataide

; Silveira, Ana Beatriz Vieira da

; Oliveira, Daniela Silva Barroso de

; Lima, Daniela Coêlho de

; Gomes, Heloisa de Sousa

Brazilian Journal of Oral Sciences

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2024, Volume 23 elocation e245360

Abstract: En | Text: En | PDF: En

Aim To compare performance differences among dental surgeons in the public sector of the state of Minas Gerais regarding prenatal dental care before and after the establishment of Previne Brasil. Methods A cross-sectional study was conducted, gathering data through a structured questionnaire. The sample consisted of dental surgeons working in the public sector of municipalities in MG and utilizing the snowball effect. Data analysis was performed using the IBM-SPSS® version 29.0, employing Pearson’s Chi-square statistical test (P<0.05). Results Out of the 28 State Health System (SRS) present in MG. A total of 1696 responses were collected, but after applying the exclusion criteria, 1001 responses remained, specifically related to dental surgeons working in MG public sector. 78.6% comprised professionals who graduated before 2019, while 20.1% graduated after that year. The morning and the second or other gestational trimesters were the most common periods considered optimal for caring for pregnant women. A significant portion of the professionals had not undergone any specific courses or training on this topic, reporting an average satisfaction level of 5.52 regarding the accessibility of information during their education aimed at this audience. Conclusion Variances were observed in the care provided to pregnant women by dental surgeons working in the public sector of Minas Gerais, distinguishing those trained before and after the implementation of Previne Brasil. The debunking of myths and taboos stands as crucial for enhancing the acceptance of prenatal dentistry. Brasil crosssectional cross sectional conducted questionnaire effect IBMSPSS® IBMSPSS IBM SPSS® SPSS IBM-SPSS 290 29 0 29.0 Pearsons Pearson s Chisquare Chi square P<0.05. P005 P P<0.05 . 05 (P<0.05) 2 SRS (SRS 169 collected criteria 100 remained 786 78 6 78.6 2019 201 20 1 20.1 year topic 552 5 52 5.5 audience dentistry 29. P00 P<0.0 (P<0.05 16 10 7 78. 20. 55 5. P0 P<0. (P<0.0 P<0 (P<0. P< (P<0 (P< (P

https://doi.org/10.20396/bjos.v23i00.8675360

15.

High PD-L1 expression is associated with unfavorable clinical features in myelodysplastic neoplasms PDL1 PDL PD L1 L PD-L
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Sampaio, Leticia Rodrigues

; Viana, Mateus de Aguiar

; Oliveira, Vanessa Silva de

; Ferreira, Bruna Vitoriano

; Melo, Mayara Magna Lima

; Oliveira, Roberta Taiane Germano de

; Borges, Daniela de Paula

; Magalhãesa, Silvia Maria Meira

; Pinheiro, Ronald F.

Hematology, Transfusion and Cell Therapy

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2024, Volume 46 N. 2 Pages 146 - 152

Abstract: En | Text: En | PDF: En

ABSTRACT Introduction: Immune checkpoints are regulators of the immune system response that allow self-tolerance. Molecules such as Programmed Cell Death Protein 1 (PD-1) and its Ligand (PD-L1) participate in the immune checkpoint by signaling co-inhibition of lymphocyte responses. In cancers, PD-L1 expression is associated with the immune evasion mechanism, which favors tumor growth. The use of anti-PD-1/PD-L1 drugs is already well described in solid tumors, but still not fully understood in hematologic malignancies. Myelodysplastic neoplasms (MDSs) are heterogeneous bone marrow disorders with an increased risk of progression to Acute Myeloid Leukemia (AML). The MDS affects hematopoietic stem cells and its pathogenesis is linked to genetic and epigenetic defects, in addition to immune dysregulation. The influence of the PD-L1 on the MDS remains unknown. Methods: In this study, we evaluated the mRNA expression of the PD-L1 in 53 patients with MDS, classified according to the WHO 2016 Classification. Results: Patients with dyserythropoiesis presented significantly higher PD-L1 expression than patients without dyserythropoiesis (p = 0.050). Patients classified as having MDS with an excess of blasts 2 (MDS-EB2) presented a significant upregulation in the mRNA expression of the PD-L1 compared to the MDS with an excess of blasts 1 (MDS-EB1) (p = 0.050). Furthermore, we detected three patients with very high levels of PD-L1 expression, being statistically classified as outliers. Conclusion: We suggested that the high expression of the PD-L1 is associated with a worse prognosis in the MDS and functional studies are necessary to evaluate the possible use of anti-PD-L1 therapies for high-risk MDS, such as the MDS-EBs. Introduction selftolerance. selftolerance self tolerance. tolerance self-tolerance PD1 PD (PD-1 PDL1 PDL L1 L (PD-L1 coinhibition co inhibition responses cancers PD-L mechanism growth antiPD1/PDL1 antiPD1PDL1 antiPDPDL anti 1/PD anti-PD-1/PD-L tumors malignancies MDSs (MDSs AML. AML . (AML) defects dysregulation unknown Methods study 5 201 Classification Results p 0.050. 0050 0.050 0 050 0.050) MDSEB2 MDSEB EB2 EB (MDS-EB2 MDSEB1 EB1 (MDS-EB1 Furthermore outliers Conclusion antiPDL1 antiPDL anti-PD-L highrisk MDSEBs. MDSEBs EBs. EBs MDS-EBs (PD- (PD-L antiPD1 antiPD antiPD1/PDL antiPD1PDL 1PD (AML 20 005 0.05 05 (MDS-EB (PD 00 0.0 0.

https://doi.org/10.1016/j.htct.2023.05.002

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