Objective: to estimate the reference intervals (RIs) of complete blood count parameters in the Brazilian adult population. Methods: Cross-sectional study, with data from the National Health Survey (PNS), between 2014-2015. The final sample consisted of 2,803 adults. The final sample consisted of 2,803 adults. To establish the RI, exclusion criteria were applied, outliers were removed and partitions were made by sex, age and race/skin color. The non-parametric method was adopted. Differences were assessed using the Mann Withney and Kruskal Wallis tests (p≤0.05). Results: There were statistically significant differences for the following hematological parameters based on sex, red blood cells, hemoglobin, hematocrit, MCH, MCHC, eosinophils and absolute monocytes, neutrophils and platelets (p≤0.05). When analyzed by age, the RIs were statistically different in females for hematocrit, MCV, white blood cells and RDW and in males for red blood cells, white blood cells, eosinophils, mean platelet volume, MCV, RDW and MCH(p≤0.05). For race/color there were differences in the RIs for parameters of hemoglobin, MCH, MCHC, white blood cells and mean platelet volume, neutrophils and absolute eosinophils (p ≤ 0.05). Conclusion: The differences found in the RIs of some in blood count parameters in Brazilian adults reaffirm the importance of having their own laboratory reference standards. The results can support a more accurate interpretation of tests, adequate identification and disease prevention in Brazil.

Objetivo: estimar os intervalos de referência (IR) de parâmetros de hemograma completo na população adulta brasileira. Métodos: Estudo transversal, com dados da Pesquisa Nacional de Saúde (PNS), entre 2014-2015. A amostra final constitui-se de 2.803 adultos. Para estabelecer os IR, aplicou-se critérios de exclusão, removeram-se outliers e feito particionamentos por sexo, idade e raça/cor da pele. Adotou-se o método não paramétrico.nbsp; As diferenças foram avaliadas pelos testes Mann Withney e Kruskal Wallis (p≤0,05). Resultados: houve diferenças estatisticamente significativas nos IR segundo sexo para glóbulos vermelhos, hemoglobina, hematócrito, HCM, CHCM, eosinófilos, monócitos, neutrófilos absolutos e plaquetas (p≤0,05). Quando analisados por idade,nbsp; houve diferenças nos IR de mulheres para hematócrito, VCM, glóbulos brancos e RDW e nos homens de glóbulos vermelhos, glóbulos brancos, eosinófilos, volume plaquetário médios, VCM, RDW e HCM (p≤0,05). Para raça/cor houve diferenças nos IR de hemoglobina, HCM, CHMC, glóbulos brancos e volume plaquetário médio, neutrófilos e eosinófilos absolutos (p ≤ 0,05). Conclusão: As diferenças encontradas nos IR de alguns em parâmetros de hemograma em adultos brasileirosnbsp; reafirmam a importância de se ter padrões de referência laborarias próprios. Os resultados podem subsidiar a interpretação mais precisa dos exames, identificação adequada e a prevenção de doenças no Brasil.

RESUMO Objetivo: Estimar os intervalos de referência (IR) de parâmetros de hemograma completo na população adulta brasileira. Métodos: Estudo transversal, com dados da Pesquisa Nacional de Saúde (PNS), entre 2014–2015. A amostra final constitui-se de 2.803 adultos. Para estabelecer os IR, aplicou-se critérios de exclusão, removeram-se outliers e foram feitos particionamentos por sexo, idade e raça/cor da pele. Adotou-se o método não paramétrico. As diferenças foram avaliadas pelos testes Mann Withney e Kruskal Wallis (p≤0,05). Resultados: Houve diferenças estatisticamente significativas nos IR segundo sexo para glóbulos vermelhos, hemoglobina, hematócrito, HCM, CHCM, eosinófilos, monócitos, neutrófilos absolutos e plaquetas (p≤0,05). Quando analisados por idade, houve diferenças nos IR de mulheres para hematócrito, VCM, glóbulos brancos e RDW, e nos homens em glóbulos vermelhos, glóbulos brancos, eosinófilos, volume plaquetário médios, VCM, RDW e HCM (p≤0,05). Para raça/cor, houve diferenças nos IR de hemoglobina, HCM, CHMC, glóbulos brancos e volume plaquetário médio, neutrófilos e eosinófilos absolutos (p≤0,05). Conclusão: As diferenças encontradas nos IR de alguns parâmetros de hemograma nos adultos brasileiros, reafirmam a importância de se ter padrões laboratoriais próprios de referência. Os resultados podem subsidiar a interpretação mais precisa dos exames, identificação adequada e a prevenção de doenças no Brasil.

ABSTRACT Objective: To estimate the reference intervals (RIs) of complete blood count parameters in the Brazilian adult population. Methods: Cross-sectional study, with data from the National Health Survey (Pesquisa Nacional de Saúde – PNS), between 2014–2015. The final sample consisted of 2,803 adults. To establish the RIs, exclusion criteria were applied, outliers were removed and partitions were made by gender, age, and race/skin color. The non-parametric method was adopted. Differences were assessed using the Mann Whitney and Kruskal Wallis tests (p≤0.05). Results: There were statistically significant differences for the following hematological parameters based on gender, red blood cells, hemoglobin, hematocrit, MCH, MCHC, eosinophils and absolute monocytes, neutrophils and platelets (p≤0.05). When analyzed by age, the RIs were statistically different in females for hematocrit, MCV, white blood cells and RDW and in males for red blood cells, white blood cells, eosinophils, mean platelet volume, MCV, RDW, and MCH (p≤0.05). For race/color, there were differences in the RIs for parameters of hemoglobin, MCH, MCHC, white blood cells and mean platelet volume, neutrophils and absolute eosinophils (p≤0.05). Conclusion: The differences found in the RIs of some in blood count parameters in Brazilian adults reaffirm the importance of having their own laboratory reference standards. The results can support a more accurate interpretation of tests, adequate identification and disease prevention in Brazil.

RESUMO Objetivo: Comparar intervalos de referência (IR) de hemograma de adultos brasileiros com e sem traço falciforme (HbAS). Métodos: Estudo transversal, com a base de dados da Pesquisa Nacional de Saúde, entre 2014-2015, composta por 8.952 indivíduos; 234 adultos constituíram a amostra com HbAS. Comparou-se IR de adultos com e sem HbAS do estudo “Valores de referência para exames laboratoriais de hemograma da população adulta brasileira: Pesquisa Nacional de Saúde”, de Rosenlfed e colaboradores (2019). Utilizaram-se o método paramétrico para estabelecer os IR e o teste t de Student para comparação (p≤0,05). Resultados: Houve diferenças estatisticamente significativas entre IR de adultos com e sem HbAS nos homens e mulheres para hemoglobina, VCM, HCM, CHCM, glóbulos brancos, linfócitos absolutos, volume plaquetário médio e RDW; em todas as idades para glóbulos brancos e RDW nos homens e para VCM, HCM, CHCM, volume plaquetário médio e RDW nas mulheres; entre 18 a 59 anos para HCM, VCM, CHCM, neutrófilos, linfócitos e plaquetas nos homens e nas mulheres para linfócitos, glóbulos vermelhos, glóbulos brancos, neutrófilos, eosinófilos, monócitos e plaquetas; a partir de 60 anos para hemoglobina e hematócrito nos homens e nas mulheres para hematócrito, glóbulos brancos, neutrófilos e plaquetas; nas raças branca, preta e parda para glóbulos brancos, neutrófilos e plaquetas (p<0,05). Conclusão: Adultos brasileiros com HbAS tiveram menores contagens de hemoglobina, VCM, HCM, CHCM, glóbulos brancos e maiores de RDW que sem HbAS. Os resultados mostram a importância do aconselhamento genético e de pesquisas para subsidiar o manejo adequado desta condição no Brasil.

ABSTRACT Objective: To compare reference intervals (RI) of blood counts of Brazilian adults with and without sickle cell trait (SCT). Methods: Cross-sectional study, based on the National Health Survey, 2014-2015, composed of 8,952 individuals. The sample of patients with SCT was composed of 234 adults. The RIs of adults with and without SCT were compared in the study “Reference values for laboratory tests of blood count in the Brazilian adult population: National Health Survey”, by Rosenfeld et al. (2019). The parametric method and the Student's t test were used for comparison (p≤0.05). Results: There were statistically significant differences between RIs of adults with and without SCT as far as sex is concerned for hemoglobin, MCV, MCH, MCHC, white blood cells, absolute lymphocytes, mean platelet volume and RDW; At all ages, for white blood cells and RDW in men and for MCV, MCH, MCHC, mean platelet volume and RDW in women; Between 18 to 59 years, for MCH, MCV, MCHC, neutrophils, lymphocytes and platelets in men and in women for lymphocytes, red blood cells, white blood cells, neutrophils, eosinophils, monocytes and platelets; From 60 years old on, for hemoglobin and hematocrit in men and in women for hematocrit, white blood cells, neutrophils and platelets; In white, black and brown people for white blood cells, neutrophils and platelets (p<0.05). Conclusion: Brazilian adults with SCT had lower counts of hemoglobin, MCV, MCH, MCHC, white blood cells and higher RDW than without SCT. The results show the importance of genetic counseling and further research to support the proper management of this condition in Brazil.

RESUMO Objetivo: Estimar os intervalos de referência (IR) de parâmetros de hemograma completo na população adulta brasileira. Métodos: Estudo transversal, com dados da Pesquisa Nacional de Saúde (PNS), entre 2014–2015. A amostra final constitui-se de 2.803 adultos. Para estabelecer os IR, aplicou-se critérios de exclusão, removeram-se outliers e foram feitos particionamentos por sexo, idade e raça/cor da pele. Adotou-se o método não paramétrico. As diferenças foram avaliadas pelos testes Mann Withney e Kruskal Wallis (p≤0,05). Resultados: Houve diferenças estatisticamente significativas nos IR segundo sexo para glóbulos vermelhos, hemoglobina, hematócrito, HCM, CHCM, eosinófilos, monócitos, neutrófilos absolutos e plaquetas (p≤0,05). Quando analisados por idade, houve diferenças nos IR de mulheres para hematócrito, VCM, glóbulos brancos e RDW, e nos homens em glóbulos vermelhos, glóbulos brancos, eosinófilos, volume plaquetário médios, VCM, RDW e HCM (p≤0,05). Para raça/cor, houve diferenças nos IR de hemoglobina, HCM, CHMC, glóbulos brancos e volume plaquetário médio, neutrófilos e eosinófilos absolutos (p≤0,05). Conclusão: As diferenças encontradas nos IR de alguns parâmetros de hemograma nos adultos brasileiros, reafirmam a importância de se ter padrões laboratoriais próprios de referência. Os resultados podem subsidiar a interpretação mais precisa dos exames, identificação adequada e a prevenção de doenças no Brasil. Objetivo (IR brasileira Métodos transversal PNS, PNS , (PNS) 20142015 2014 2015 2014–2015 constituise constitui 2803 2 803 2.80 aplicouse aplicou exclusão removeramse removeram raçacor raça cor pele Adotouse Adotou paramétrico p≤0,05. p005 p p≤0,05 . 0 05 (p≤0,05) Resultados vermelhos hemoglobina hematócrito CHCM monócitos VCM médios CHMC médio Conclusão brasileiros exames Brasil (PNS 2014201 201 2014–201 280 80 2.8 p00 p≤0,0 (p≤0,05 201420 20 2014–20 28 8 2. p0 p≤0, (p≤0,0 20142 2014–2 p≤0 (p≤0, 2014– p≤ (p≤0 (p≤ (p

ABSTRACT Objective: To estimate the reference intervals (RIs) of complete blood count parameters in the Brazilian adult population. Methods: Cross-sectional study, with data from the National Health Survey (Pesquisa Nacional de Saúde – PNS), between 2014–2015. The final sample consisted of 2,803 adults. To establish the RIs, exclusion criteria were applied, outliers were removed and partitions were made by gender, age, and race/skin color. The non-parametric method was adopted. Differences were assessed using the Mann Whitney and Kruskal Wallis tests (p≤0.05). Results: There were statistically significant differences for the following hematological parameters based on gender, red blood cells, hemoglobin, hematocrit, MCH, MCHC, eosinophils and absolute monocytes, neutrophils and platelets (p≤0.05). When analyzed by age, the RIs were statistically different in females for hematocrit, MCV, white blood cells and RDW and in males for red blood cells, white blood cells, eosinophils, mean platelet volume, MCV, RDW, and MCH (p≤0.05). For race/color, there were differences in the RIs for parameters of hemoglobin, MCH, MCHC, white blood cells and mean platelet volume, neutrophils and absolute eosinophils (p≤0.05). Conclusion: The differences found in the RIs of some in blood count parameters in Brazilian adults reaffirm the importance of having their own laboratory reference standards. The results can support a more accurate interpretation of tests, adequate identification and disease prevention in Brazil. Objective (RIs population Methods Crosssectional Cross sectional study Pesquisa PNS, PNS , PNS) 20142015 2014 2015 2014–2015 2803 2 803 2,80 applied gender age raceskin race skin color nonparametric non parametric adopted p≤0.05. p005 p p≤0.05 . 0 05 (p≤0.05) Results hemoglobin hematocrit MCHC monocytes MCV volume racecolor race/color Conclusion standards Brazil 2014201 201 2014–201 280 80 2,8 p00 p≤0.0 (p≤0.05 201420 20 2014–20 28 8 2, p0 p≤0. (p≤0.0 20142 2014–2 p≤0 (p≤0. 2014– p≤ (p≤0 (p≤ (p

RESUMO Objetivo: Comparar intervalos de referência (IR) de hemograma de adultos brasileiros com e sem traço falciforme (HbAS). Métodos: Estudo transversal, com a base de dados da Pesquisa Nacional de Saúde, entre 2014-2015, composta por 8.952 indivíduos; 234 adultos constituíram a amostra com HbAS. Comparou-se IR de adultos com e sem HbAS do estudo “Valores de referência para exames laboratoriais de hemograma da população adulta brasileira: Pesquisa Nacional de Saúde”, de Rosenlfed e colaboradores (2019). Utilizaram-se o método paramétrico para estabelecer os IR e o teste t de Student para comparação (p≤0,05). Resultados: Houve diferenças estatisticamente significativas entre IR de adultos com e sem HbAS nos homens e mulheres para hemoglobina, VCM, HCM, CHCM, glóbulos brancos, linfócitos absolutos, volume plaquetário médio e RDW; em todas as idades para glóbulos brancos e RDW nos homens e para VCM, HCM, CHCM, volume plaquetário médio e RDW nas mulheres; entre 18 a 59 anos para HCM, VCM, CHCM, neutrófilos, linfócitos e plaquetas nos homens e nas mulheres para linfócitos, glóbulos vermelhos, glóbulos brancos, neutrófilos, eosinófilos, monócitos e plaquetas; a partir de 60 anos para hemoglobina e hematócrito nos homens e nas mulheres para hematócrito, glóbulos brancos, neutrófilos e plaquetas; nas raças branca, preta e parda para glóbulos brancos, neutrófilos e plaquetas (p<0,05). Conclusão: Adultos brasileiros com HbAS tiveram menores contagens de hemoglobina, VCM, HCM, CHCM, glóbulos brancos e maiores de RDW que sem HbAS. Os resultados mostram a importância do aconselhamento genético e de pesquisas para subsidiar o manejo adequado desta condição no Brasil. Objetivo (IR . (HbAS) Métodos transversal Saúde 20142015, 20142015 2014 2015, 2015 2014-2015 8952 8 952 8.95 indivíduos 23 Comparouse Comparou se Valores brasileira , Saúde” 2019. 2019 (2019) Utilizaramse Utilizaram p≤0,05. p005 p p≤0,05 0 05 (p≤0,05) Resultados VCM HCM CHCM absolutos 1 5 vermelhos eosinófilos 6 branca p<0,05. p<0,05 (p<0,05) Conclusão Brasil (HbAS 2014201 201 2014-201 895 95 8.9 2 (2019 p00 p≤0,0 (p≤0,05 p<0,0 (p<0,05 201420 20 2014-20 89 9 8. (201 p0 p≤0, (p≤0,0 p<0, (p<0,0 20142 2014-2 (20 p≤0 (p≤0, p<0 (p<0, 2014- (2 p≤ (p≤0 p< (p<0 ( (p≤ (p< (p

ABSTRACT Objective: To compare reference intervals (RI) of blood counts of Brazilian adults with and without sickle cell trait (SCT). Methods: Cross-sectional study, based on the National Health Survey, 2014-2015, composed of 8,952 individuals. The sample of patients with SCT was composed of 234 adults. The RIs of adults with and without SCT were compared in the study “Reference values for laboratory tests of blood count in the Brazilian adult population: National Health Survey”, by Rosenfeld et al. (2019). The parametric method and the Student's t test were used for comparison (p≤0.05). Results: There were statistically significant differences between RIs of adults with and without SCT as far as sex is concerned for hemoglobin, MCV, MCH, MCHC, white blood cells, absolute lymphocytes, mean platelet volume and RDW; At all ages, for white blood cells and RDW in men and for MCV, MCH, MCHC, mean platelet volume and RDW in women; Between 18 to 59 years, for MCH, MCV, MCHC, neutrophils, lymphocytes and platelets in men and in women for lymphocytes, red blood cells, white blood cells, neutrophils, eosinophils, monocytes and platelets; From 60 years old on, for hemoglobin and hematocrit in men and in women for hematocrit, white blood cells, neutrophils and platelets; In white, black and brown people for white blood cells, neutrophils and platelets (p<0.05). Conclusion: Brazilian adults with SCT had lower counts of hemoglobin, MCV, MCH, MCHC, white blood cells and higher RDW than without SCT. The results show the importance of genetic counseling and further research to support the proper management of this condition in Brazil. Objective RI (RI . (SCT) Methods Crosssectional Cross sectional Survey 20142015, 20142015 2014 2015, 2015 2014-2015 8952 8 952 8,95 individuals 23 Reference population , Survey” al 2019. 2019 (2019) Students Student s p≤0.05. p005 p p≤0.05 0 05 (p≤0.05) Results MCV MCH MCHC ages 1 5 eosinophils 6 p<0.05. p<0.05 (p<0.05) Conclusion Brazil (SCT 2014201 201 2014-201 895 95 8,9 2 (2019 p00 p≤0.0 (p≤0.05 p<0.0 (p<0.05 201420 20 2014-20 89 9 8, (201 p0 p≤0. (p≤0.0 p<0. (p<0.0 20142 2014-2 (20 p≤0 (p≤0. p<0 (p<0. 2014- (2 p≤ (p≤0 p< (p<0 ( (p≤ (p< (p

Objective: to compare reference intervals (RI) of blood counts of Brazilian adults with and without sickle cell trait (SCT). Methods: Cross-sectional study, with the National Health Survey, 2014-2015, composed of 8,952 individuals. 234 adults constituted the sample with SCT. The RI of adults with and without SCT were compared in the study “Reference values ​​for laboratory tests of blood count in the Brazilian adult population: National Health Survey”, by Rosenlfed et al. (2019). The parametric method was used and Student's t test for comparison (p≤0.05). Results: There were statistically significant differences between RI of adults with and without SCT in men and women for hemoglobin, MCV, HCM, CHCM, white blood cells, absolute lymphocytes, mean platelet volume and RDW; At all ages, for white blood cells and RDW in men and for MCV, HCM, CHCM, mean platelet volume and RDW in women; Between 18 to 59 years, for HCM, MCV, CHCM, neutrophils, lymphocytes and platelets in men and in women for lymphocytes, red blood cells, white blood cells, neutrophils, eosinophils, monocytes and platelets; From 60 years, for hemoglobin and hematocrit in men and in women for hematocrit, white blood cells, neutrophils and platelets; In white, black and brown races for white blood cells, neutrophils and platelets (p&lt;0.05). Conclusion: Brazilian adults with SCT had lower counts of hemoglobin, MCV, HCM, CHCM, white blood cells and higher RDW than without SCT. The results show the importance of genetic counseling and research to support the proper management of this condition in Brazil.

Objetivo: comparar intervalos de referência (IR) de hemograma de adultos brasileiros com e sem traço falciforme (HbAS). Métodos: Estudo transversal,  com a base de dados da Pesquisa Nacional de Saúde, entre 2014-2015, composta por 8.952 indivíduos. 234 adultos  constituíram  a amostra com HbAS Comparou-se IR de adultos com e os sem HbAS do estudo “Valores de referência para exames laboratoriais de hemograma da população adulta brasileira: Pesquisa Nacional de Saúde”, de Rosenlfed e colaboradores (2019). Utilizaram-se o método paramétrico para estabelecer os IR e o teste t de Student para comparação (p≤0,05). Resultados: Houve diferenças estatisticamente significativas entre IR de adultos com e sem HbAS nos homens e mulheres para hemoglobina, VCM, HCM, CHCM, glóbulos brancos, linfócitos absolutos, volume plaquetário médio e RDW; Em todas as idades, para glóbulos brancos e RDW nos homens e para VCM, HCM, CHCM, volume plaquetário médio e RDW nas mulheres; Entre 18 a 59 anos, para HCM, VCM, CHCM, neutrófilos, linfócitos e plaquetas nos homens e nas mulheres para linfócitos, glóbulos vermelhos, glóbulos brancos, neutrófilos, eosinófilos, monócitos e plaquetas;  A partir de 60 anos, para hemoglobina e hematócrito nos homens e nas mulheres para hematócrito, glóbulos brancos, neutrófilos e plaquetas;  Nas raças branca, preta e parda para glóbulos brancos, neutrófilos e plaquetas (p&lt;0,05). Conclusão: Adultos brasileiros com HbAS tiveram menores contagens de hemoglobina, VCM, HCM, CHCM, glóbulos brancos e maiores de RDW que sem HbAS. Os resultados mostram a importância do aconselhamento genético e pesquisas para subsidiar o manejo adequado desta condição no Brasil.

Resumo Objetivo: analisar a prevalência de escolares vacinados contra o papilomavírus humano (HPV) e os motivos relacionados à não vacinação. Método: estudo transversal, com dados da Pesquisa Nacional de Saúde do Escolar de 2019. A amostra foi composta por 160.721 estudantes de 13 a 17 anos. Foram estimadas as prevalências e intervalos de confiança (IC95%) de adolescentes vacinados segundo localização, sexo e dependência administrativa da escola. Avaliaram-se as diferenças entre os estratos pelo teste Qui-quadrado. Estimaram-se as razões de prevalência ajustadas (RPa) e os IC95% pelo modelo de regressão de Poisson. Resultados: a maioria dos escolares foram vacinados (62,9%), sendo a prevalência de meninas (76,1%) superior à de meninos (49,1%). O motivo mais prevalente foi “não sabia que tinha que tomar” (46,8%), sendo as RPa mais elevadas em escolares de escolas públicas do Brasil (1,6; IC95% 1,5;1,7), da região Nordeste (1,2; IC95% 1,1;1,2) e em estudantes de escolas privadas das regiões Nordeste (1,1; IC95% 1,1;1,2) e Norte (1,3; IC95% 1,2;1,4). Conclusão: um a cada dois escolares brasileiros foi vacinado contra o HPV. A desinformação foi um motivo frequente para a não vacinação. As regiões Norte e Nordeste apresentaram as maiores prevalências de não vacinados, observadas principalmente em adolescentes de escolas públicas.

Abstract Objective: to analyze the prevalence of schoolchildren vaccinated against human papillomavirus (HPV) and the reasons related to non-vaccination. Method: cross-sectional study, with data from the 2019 National Survey of School Health. The sample consisted of 160,721 students aged 13 to 17 years. The prevalence and confidence intervals (95%CI) of vaccinated adolescents were estimated according to location, sex, and administrative dependence of the school. The differences between the strata were evaluated with the Chi-square test. Adjusted prevalence ratios (aPR) and 95%CI were estimated with the Poisson regression model. Results: most of the students were vaccinated (62.9%), and the prevalence of girls (76.1%) was higher than that of boys (49.1%). The most prevalent reason for not vaccinating was “did not know they had to take” (46.8%), with the highest aPR in public schoolchildren in Brazil (1.6; 95%CI 1.5;1.7), from the Northeast region (1.2; 95%CI 1.1;1.2), and in students from private schools in the Northeast regions (1.1; 95%CI 1.1;1.2) and North (1.3; 95%CI 1.2;1.4). Conclusion: one out of every two Brazilian schoolchildren was vaccinated against HPV. Misinformation was a recurring reason for non-vaccination. The North and Northeast regions had the highest prevalence of non-vaccinated people, observed mainly in adolescents from public schools.

Resumen Objetivo: analizar la prevalencia de escolares vacunados contra el virus del papiloma humano (VPH) y las razones relacionadas con la no vacunación. Método: estudio transversal, con datos de la Encuesta Nacional de Salud del Escolar de 2019. La muestra estuvo compuesta por 160, 721 estudiantes de 13 a 17 años. Se estimaron las prevalencias e intervalos de confianza (IC95%) de adolescentes vacunados según ubicación, sexo y dependencia administrativa de la escuela. Las diferencias entre estratos se evaluaron mediante la prueba de Chi-cuadrado. Se estimaron las razones de prevalencia ajustadas (RPa) y los IC95% por el modelo de regresión de Poisson. Resultados: la mayoría de los escolares fueron vacunados (62,9%), siendo la prevalencia de niñas (76,1%) superior a la de los niños (49,1%). La razón más prevalente fue “no sabía que tenía que tomar” (46,8%), siendo las RPa más elevadas en escolares de escuelas públicas de Brasil (1,6; IC95% 1,5; 1,7), de la región Nordeste (1,2; IC95% 1,1; 1,2) y en estudiantes de escuelas privadas de las regiones de Nordeste (1,1; IC95% 1,1; 1,2) y Norte (1,3; IC95% 1,2; 1,4). Conclusión: uno de cada dos escolares brasileños ha sido vacunado contra el VPH. La desinformación fue una razón frecuente para la no vacunación. Las regiones Norte y Nordeste presentaron las mayores prevalencias de no vacunados, observadas principalmente en adolescentes de escuelas públicas.

ABSTRACT OBJECTIVE To analyze the number of yellow fever vaccine doses administered before and during the covid-19 pandemic in Brazil. METHODS This is an ecological, time series study based on data from the National Immunization Program. Differences between the median number of yellow fever vaccine doses administered in Brazil and in its regions before (from April/2019 to March/2020) and after (from April/2020 to March/2021) the implementation of social distancing measures in the country were assessed via the Mann-Whitney test. Prais-Winsten regression models were used for time series analyses. RESULTS We found a reduction in the median number of yellow fever vaccine doses administered in Brazil and in its regions: North (-34.71%), Midwest (-21.72%), South (-63.50%), and Southeast (-34.42%) (p < 0.05). Series showed stationary behavior in Brazil and in its five regions during the covid-19 pandemic (p > 0.05). Brazilian states also showed stationary trends, except for two states which recorded an increasing trend in the number of administered yellow fever vaccine doses, namely: Alagoas State (before: β = 64, p = 0.081; after: β = 897, p = 0.039), which became a yellow fever vaccine recommendation zone, and Roraima State (before: β = 68, p = 0.724; after: β = 150, p = 0.000), which intensified yellow fever vaccinations due to a yellow fever case confirmation in a Venezuelan State in 2020. CONCLUSION The reduced number of yellow fever vaccine doses administered during the covid-19 pandemic in Brazil may favor the reemergence of urban yellow fever cases in the country.

Resumo O estudo analisa a prevalência de diabetes autorreferido e fatores associados na população adulta brasileira. Estudo transversal usando a Pesquisa Nacional de Saúde 2019. Estimaram-se as prevalências e razões de prevalência brutas (RPb) e ajustadas (RPa) de diabetes autorreferido, com intervalos de confiança (IC95%), empregando-se regressão de Poisson. Nos 82.349 adultos, a prevalência de diabetes autorreferido foi de 7,7%. Associaram-se positivamente: idade avançada, sendo maior após 60 anos (RPa 24,87; IC95%: 15,78-39,18); residir nas regiões Nordeste (RPa 1,16; IC95%: 1,04-1,29), Sudeste (RPa 1,27; IC95%: 1,14-1,43), Sul (RPa 1,18; IC95%: 1,05-1,34) e Centro-Oeste (RPa 1,21; IC95%: 1,06-1,38), ser ex-fumante (RPa 1,17; IC95%: 1,09-1,27), autoavaliação de saúde regular (RPa 2,41; IC95%: 2,21-2,64), ruim/muito ruim (RPa 3,45; IC95%: 3,06-3,88), ter doença cardíaca (RPa 1,81; IC95%: 1,64-2,00), hipertensão (RPa 2,84; IC95%: 2,60-3,69), colesterol elevado (RPa 2,22; IC95%: 2,05-2,41), sobrepeso (RPa 1,49; IC95%: 1,36-1,64) e obesidade (RPa 2,25; IC95%: 2,05- 2,47). Conclui-se que o diabetes nos adultos brasileiros se associa a fatores sociodemográficos, envelhecimento, estilos de vida e morbidades. Esses resultados podem orientar políticas públicas para prevenção e controle da doença no Brasil.

Abstract This study aims to analyze the prevalence of self-reported diabetes and its associated factors in the Brazilian adult population. It is a cross-sectional study using the 2019 National Health Survey. Prevalence and crude prevalence ratios (PRc) and adjusted prevalence ratios (PRa) of self-reported diabetes were estimated, with confidence intervals (95% CI), using Poisson regression. In the 82,349 adults, the prevalence of self-reported diabetes was 7.7%. Positively associated factors were: advanced age with greater association after 60 years (PRa 24.87; 95%CI 15.78-39.18); living in the Northeast (PRa 1.16; 95%CI 1.04-1.29), Southeast (PRa 1.27; 95% CI 1.14-1.43), South (PRa 1.18; 95%CI 1, 05-1.34), and Midwest (PRa 1.21; 95%CI 1.06-1.38); being a former smoker (PRa 1.17; 95%CI 1.09-1.27); self-assessment of regular health (PRa 2.41; 95%CI 2.21-2.64), bad/very bad (PRa 3.45; 95%CI 3.06-3.88); having heart disease (PRa 1.81; 95%CI 1.64-2.00), hypertension (PRa 2.84; 95%CI 2.60-3.69), high cholesterol (PRa 2.22; 95%CI 2.05-2.41), overweight (PRa 1.49; 95%CI 1.36-1.64), and obesity (PRa 2.25; 95%CI 2.05-2.47). It could be concluded that diabetes in Brazilian adults is associated with sociodemographic factors, aging, lifestyle, and morbidities. These results can guide public policies for the prevention and control of disease in Brazil.

ABSTRACT OBJECTIVE To analyze the number of yellow fever vaccine doses administered before and during the covid-19 pandemic in Brazil. METHODS This is an ecological, time series study based on data from the National Immunization Program. Differences between the median number of yellow fever vaccine doses administered in Brazil and in its regions before (from April/2019 to March/2020) and after (from April/2020 to March/2021) the implementation of social distancing measures in the country were assessed via the Mann-Whitney test. Prais-Winsten regression models were used for time series analyses. RESULTS We found a reduction in the median number of yellow fever vaccine doses administered in Brazil and in its regions: North (-34.71%), Midwest (-21.72%), South (-63.50%), and Southeast (-34.42%) (p < 0.05). Series showed stationary behavior in Brazil and in its five regions during the covid-19 pandemic (p > 0.05). Brazilian states also showed stationary trends, except for two states which recorded an increasing trend in the number of administered yellow fever vaccine doses, namely: Alagoas State (before: β = 64, p = 0.081; after: β = 897, p = 0.039), which became a yellow fever vaccine recommendation zone, and Roraima State (before: β = 68, p = 0.724; after: β = 150, p = 0.000), which intensified yellow fever vaccinations due to a yellow fever case confirmation in a Venezuelan State in 2020. CONCLUSION The reduced number of yellow fever vaccine doses administered during the covid-19 pandemic in Brazil may favor the reemergence of urban yellow fever cases in the country.

Resumo O estudo analisa a prevalência de diabetes autorreferido e fatores associados na população adulta brasileira. Estudo transversal usando a Pesquisa Nacional de Saúde 2019. Estimaram-se as prevalências e razões de prevalência brutas (RPb) e ajustadas (RPa) de diabetes autorreferido, com intervalos de confiança (IC95%), empregando-se regressão de Poisson. Nos 82.349 adultos, a prevalência de diabetes autorreferido foi de 7,7%. Associaram-se positivamente: idade avançada, sendo maior após 60 anos (RPa 24,87; IC95%: 15,78-39,18); residir nas regiões Nordeste (RPa 1,16; IC95%: 1,04-1,29), Sudeste (RPa 1,27; IC95%: 1,14-1,43), Sul (RPa 1,18; IC95%: 1,05-1,34) e Centro-Oeste (RPa 1,21; IC95%: 1,06-1,38), ser ex-fumante (RPa 1,17; IC95%: 1,09-1,27), autoavaliação de saúde regular (RPa 2,41; IC95%: 2,21-2,64), ruim/muito ruim (RPa 3,45; IC95%: 3,06-3,88), ter doença cardíaca (RPa 1,81; IC95%: 1,64-2,00), hipertensão (RPa 2,84; IC95%: 2,60-3,69), colesterol elevado (RPa 2,22; IC95%: 2,05-2,41), sobrepeso (RPa 1,49; IC95%: 1,36-1,64) e obesidade (RPa 2,25; IC95%: 2,05- 2,47). Conclui-se que o diabetes nos adultos brasileiros se associa a fatores sociodemográficos, envelhecimento, estilos de vida e morbidades. Esses resultados podem orientar políticas públicas para prevenção e controle da doença no Brasil.

Abstract This study aims to analyze the prevalence of self-reported diabetes and its associated factors in the Brazilian adult population. It is a cross-sectional study using the 2019 National Health Survey. Prevalence and crude prevalence ratios (PRc) and adjusted prevalence ratios (PRa) of self-reported diabetes were estimated, with confidence intervals (95% CI), using Poisson regression. In the 82,349 adults, the prevalence of self-reported diabetes was 7.7%. Positively associated factors were: advanced age with greater association after 60 years (PRa 24.87; 95%CI 15.78-39.18); living in the Northeast (PRa 1.16; 95%CI 1.04-1.29), Southeast (PRa 1.27; 95% CI 1.14-1.43), South (PRa 1.18; 95%CI 1, 05-1.34), and Midwest (PRa 1.21; 95%CI 1.06-1.38); being a former smoker (PRa 1.17; 95%CI 1.09-1.27); self-assessment of regular health (PRa 2.41; 95%CI 2.21-2.64), bad/very bad (PRa 3.45; 95%CI 3.06-3.88); having heart disease (PRa 1.81; 95%CI 1.64-2.00), hypertension (PRa 2.84; 95%CI 2.60-3.69), high cholesterol (PRa 2.22; 95%CI 2.05-2.41), overweight (PRa 1.49; 95%CI 1.36-1.64), and obesity (PRa 2.25; 95%CI 2.05-2.47). It could be concluded that diabetes in Brazilian adults is associated with sociodemographic factors, aging, lifestyle, and morbidities. These results can guide public policies for the prevention and control of disease in Brazil.

Abstract Objective: To estimate the prevalence of self-reported high cholesterol diagnosis and to analyze the factors associated with the prevalence in the Brazilian adult population. Methods: Cross-sectional study, using data from the 2019 National Health Survey. The diagnosis of high cholesterol was self-reported. Poisson regression models yielded prevalence ratios (PR) and 95% confidence intervals (95%CI). Results: In the 88,531 adults, the prevalence of high cholesterol was 14.6%. Positively associated: female sex (PR = 1.44; 95%CI 1.40;1.52), age ≥ 60 years (PR = 3.80; 95%CI 3.06;4.71), health insurance (PR = 1.33; 95%CI 1.24;1.42), poor or very poor self-rated health (PR = 1.75; 95%CI 1.60;1.90), hypertension (PR = 1.78; 95%CI 1.68;-1.89), diabetes (RP = 1.54; 95%CI 1.45;1.65), renal failure (PR = 1.33; 95%CI 1.15;1.53), obesity (PR = 1.27; 95%CI 1.18;1.36), former smoker (PR = 1.13; 95%CI 1.07;1.20), alcohol abuse (PR = 1.11; 95%CI 1.01;1.21), physically active during leisure time (PR = 1.22; 95%CI 1.15;1.30). Conclusion: High cholesterol was associated with sociodemographic characteristics, health condition and lifestyle.

Resumo Objetivo: Estimar a prevalência de diagnóstico autorreferido de colesterol alto e analisar os fatores associados à prevalência na população adulta brasileira. Métodos: Estudo transversal utilizando a Pesquisa Nacional de Saúde 2019. O diagnóstico de colesterol alto foi autorreferido. Modelos de regressão de Poisson originaram as razões de prevalência (RP) e intervalos de confiança de 95% (IC95%). Resultados: Nos 88.531 adultos, a prevalência de colesterol alto foi de 14,6%. Associaram-se positivamente: sexo feminino (RP = 1,44; IC95% 1,40;1,52), idade ≥ 60 anos (RP = 3,80; IC95% 3,06;4,71), ter plano de saúde (RP = 1,33; IC95% 1,24;1,42), autoavaliação de saúde ruim ou muito ruim (RP = 1,75; IC95% 1,60;1,90), ter hipertensão (RP = 1,78; IC95% 1,68;1,89), ter diabetes (RP = 1,54; IC95% 1,45;1,65), ter insuficiência renal (RP = 1,33; IC95% 1,15;1,53), ter obesidade (RP = 1,27; IC95% 1,18;1,36), ser ex-fumante (RP = 1,13; IC95% 1,07;1,20), consumir álcool abusivamente (RP = 1,11; IC95% 1,01;1,21), ser ativo no lazer (RP = 1,22; IC95% 1,15;1,30). Conclusão: O colesterol alto associou-se a condições sociodemográficas, de saúde e estilo de vida.

Resumen Objetivo: Estimar la prevalencia de colesterol alto autodeclarado y analizar factores asociados la prevalencia en adultos brasileños. Métodos: Estudio transversal utilizando la Encuesta Nacional de Salud de 2019. El diagnóstico de colesterol alto fue autodeclarado. Los modelos de regresión de Poisson produjeron razón de prevalencia (RP) e intervalos de confianza del 95% (IC95%). Resultados: En 88.531 adultos, la prevalencia fue 14,6%. Asociaron positivamente: sexo feminino (RP = 1,44; IC95% 1,40;1,52), edad ≥ 60 años (RP = 3,80; IC95% 3,06;4,71), seguro salud (RP = 1,33; IC95% 1,24;1,42), autoevaluación de salud mala o muy mala (RP = 1,75; IC95% 1,60;1,90), hipertensión (RP = 1,78; IC95% 1,68;1,89), diabetes (RP = 1,54; IC95% 1,45;1,65), insuficiencia renal (RP = 1,33; IC95% 1,15;1,53), obesidad (RP = 1,27; IC95% 1,18;1,36), exfumador (RP = 1,13; IC95% 1,07;1,20), abuso de alcohol (RP = 1,11; IC95% 1,01;1,21), estar activo en el tiempo libre (RP = 1,22; IC95% 1,15;1,30). Conclusión: Colesterol alto se asoció con condiciones sociodemográficas, de salud y estilo de vida.

Resumo Objetivo: Estimar a prevalência de diagnóstico autorreferido de colesterol alto e analisar os fatores associados à prevalência na população adulta brasileira. Métodos: Estudo transversal utilizando a Pesquisa Nacional de Saúde 2019. O diagnóstico de colesterol alto foi autorreferido. Modelos de regressão de Poisson originaram as razões de prevalência (RP) e intervalos de confiança de 95% (IC95%). Resultados: Nos 88.531 adultos, a prevalência de colesterol alto foi de 14,6%. Associaram-se positivamente: sexo feminino (RP = 1,44; IC95% 1,40;1,52), idade ≥ 60 anos (RP = 3,80; IC95% 3,06;4,71), ter plano de saúde (RP = 1,33; IC95% 1,24;1,42), autoavaliação de saúde ruim ou muito ruim (RP = 1,75; IC95% 1,60;1,90), ter hipertensão (RP = 1,78; IC95% 1,68;1,89), ter diabetes (RP = 1,54; IC95% 1,45;1,65), ter insuficiência renal (RP = 1,33; IC95% 1,15;1,53), ter obesidade (RP = 1,27; IC95% 1,18;1,36), ser ex-fumante (RP = 1,13; IC95% 1,07;1,20), consumir álcool abusivamente (RP = 1,11; IC95% 1,01;1,21), ser ativo no lazer (RP = 1,22; IC95% 1,15;1,30). Conclusão: O colesterol alto associou-se a condições sociodemográficas, de saúde e estilo de vida.

Abstract Objective: To estimate the prevalence of self-reported high cholesterol diagnosis and to analyze the factors associated with the prevalence in the Brazilian adult population. Methods: Cross-sectional study, using data from the 2019 National Health Survey. The diagnosis of high cholesterol was self-reported. Poisson regression models yielded prevalence ratios (PR) and 95% confidence intervals (95%CI). Results: In the 88,531 adults, the prevalence of high cholesterol was 14.6%. Positively associated: female sex (PR = 1.44; 95%CI 1.40;1.52), age ≥ 60 years (PR = 3.80; 95%CI 3.06;4.71), health insurance (PR = 1.33; 95%CI 1.24;1.42), poor or very poor self-rated health (PR = 1.75; 95%CI 1.60;1.90), hypertension (PR = 1.78; 95%CI 1.68;-1.89), diabetes (RP = 1.54; 95%CI 1.45;1.65), renal failure (PR = 1.33; 95%CI 1.15;1.53), obesity (PR = 1.27; 95%CI 1.18;1.36), former smoker (PR = 1.13; 95%CI 1.07;1.20), alcohol abuse (PR = 1.11; 95%CI 1.01;1.21), physically active during leisure time (PR = 1.22; 95%CI 1.15;1.30). Conclusion: High cholesterol was associated with sociodemographic characteristics, health condition and lifestyle.

Resumen Objetivo: Estimar la prevalencia de colesterol alto autodeclarado y analizar factores asociados la prevalencia en adultos brasileños. Métodos: Estudio transversal utilizando la Encuesta Nacional de Salud de 2019. El diagnóstico de colesterol alto fue autodeclarado. Los modelos de regresión de Poisson produjeron razón de prevalencia (RP) e intervalos de confianza del 95% (IC95%). Resultados: En 88.531 adultos, la prevalencia fue 14,6%. Asociaron positivamente: sexo feminino (RP = 1,44; IC95% 1,40;1,52), edad ≥ 60 años (RP = 3,80; IC95% 3,06;4,71), seguro salud (RP = 1,33; IC95% 1,24;1,42), autoevaluación de salud mala o muy mala (RP = 1,75; IC95% 1,60;1,90), hipertensión (RP = 1,78; IC95% 1,68;1,89), diabetes (RP = 1,54; IC95% 1,45;1,65), insuficiencia renal (RP = 1,33; IC95% 1,15;1,53), obesidad (RP = 1,27; IC95% 1,18;1,36), exfumador (RP = 1,13; IC95% 1,07;1,20), abuso de alcohol (RP = 1,11; IC95% 1,01;1,21), estar activo en el tiempo libre (RP = 1,22; IC95% 1,15;1,30). Conclusión: Colesterol alto se asoció con condiciones sociodemográficas, de salud y estilo de vida.

Objective: to estimate the prevalence and investigate the sociodemographic, health and lifestyle factors associated with the self-reported diagnosis of Cardiovascular Disease (CVD) in the Brazilian adult population. Methods: Data from the National Health Survey (PNS 2019). &nbsp;The presence of CVD was self-reported through the question: "Has any doctor ever given you a diagnosis of heart disease?". Sociodemographic factors, health conditions and lifestyle were evaluated. For data analysis, Poisson Regression with robust variance was used. Results: 5.3% (95% CI: 5.04 -5.57) of Brazilian adults reported CVD, and of these, 29.08% (95% CI: 27.04-31.21) underwent bypass surgery or angioplasty and 8.26% (95% CI: 7.09-9.6) reported severe limitation in usual activities due to CD. The factors associated with CVD were advanced age; be male; race/ color white; have complete elementary and high school education; have a health plan; self-assess health as regular or bad/very bad; self-report hypertension, high cholesterol and diabetes; be a former smoker, consume fruits and vegetables as recommended, do not abuse alcohol abusively and do not practice leisure-time physical activity. Conclusions: CVD is associated with sociodemographic, health and lifestyle factors. It is important to support public policies, programs and goals for the reduction of cardiovascular diseases in Brazil, especially in the most vulnerable groups.

Objetivo: estimar a prevalência e investigar os fatores sociodemográficos, de saúde e estilo de vida associados ao diagnóstico autorreferido de doença cardiovascular (DCV)&nbsp; na população adulta brasileira. Métodos: Foram analisados dados da Pesquisa Nacional de Saúde (PNS 2019). A presença de DCV foi autorreferido por meio da pergunta: “Algum médico já lhe deu o diagnóstico de uma doença do coração?”. Foi avaliado os fatores sociodemográficos, condições de saúde e estilo de vida. Para análise dos dados utilizou-se a Regressão de Poisson com variância robusta. Resultados: 5,3% (IC95%: 5,04 -5,57) dos adultos brasileiros referiram DCV, e destes, 29,08% (IC95%: 27,04-31,21) realizaram cirurgia revascularização miocárdica ou angioplastia coronariana e 8,26% (IC95%: 7,09-9,6) relataram limitação intensa nas atividades habituais devido a DCV. Os fatores associados a DCV foram a idade avançada; ser do sexo masculino; raça/cor branca; ter ensino&nbsp;fundamental completo e médio incompleto; possuir plano de saúde; autoavaliar a saúde como regular ou ruim/muito ruim; autorrelatar hipertensão, colesterol alto e diabetes; ser ex-fumante e consumir frutas e hortaliças conforme o recomendado, não consumir álcool de forma abusiva e não praticar atividade física no lazer. Conclusões: A DCV está associada à fatores sociodemográficos, de saúde e estilos de vida. Torna-se importante apoiar políticas públicas, programas e metas para a redução das doenças cardiovasculares no Brasil, especialmente nos grupos mais vulneráveis.&nbsp;

RESUMO O objetivo do estudo foi analisar a mortalidade indígena no Brasil em 2000, 2010 e 2018. Estudo descritivo com dados do Sistema de Informação sobre Mortalidade. Calculou-se a mortalidade proporcional entre indígenas e restante da população brasileira, segundo idade, sexo, causa e regiões do Brasil. A proporção de óbitos em indígenas menores de 1 ano em 2000, 2010 e 2018 foi de 15,3%, 17,7% e 16,2%; e no restante do Brasil, foi de 7,2%, 3,5% e 2,7% respectivamente. A proporção de óbitos a partir de 50 anos nos indígenas nos mesmos anos foi de 47,0%, 48,1% e 52,0%; e no restante do Brasil, foi de 66,8%, 74,4% e 79,4%. Em 2018, indígenas menores de 1 ano morreram mais de afecções perinatais (39,4%), doenças infecciosas e parasitárias (10,1%) e causas externas (9,8%). Em menores de 1 ano do restante da população brasileira, essas causas corresponderam a 57,8%, 3,8% e 2,8%. Indígenas acima de 50 anos morreram mais por doenças circulatórias (28,6%), respiratórias (15,4%) e neoplasias (14,6%); e no restante da população brasileira, essas causas representaram 31,5%, 13,6% e 19,0%. Evidenciaram-se desigualdades em saúde e piores indicadores nos povos indígenas no Brasil.

ABSTRACT This study aims to analyze indigenous mortality in Brazil in 2000, 2010, and 2018. This is a descriptive study with data from the Mortality Information System (SIM, in Portuguese). Proportional mortality among indigenous people and the remaining Brazilian population was calculated according to age, sex, cause, and regions of Brazil. The proportion of deaths among indigenous people, for individuals younger than one year of age, in 2000, 2010, and 2018 was 15.3%, 17.7%, and 16.2%, respectively. The proportions for the general Brazilian population were 7.2%, 3.5%, and 2.7%, respectively. For indigenous people aged 50 years and over, the proportions in the same years were 47.0%, 48.1%, and 52.0% and in the rest of Brazil, 66.8%, 74.4%, and 79.4%, respectively. In 2018, indigenous children under 1 year of age died more from perinatal disorders (39.4%), infectious and parasitic diseases (10.1%), and external causes (9.8%). In children under 1 year of age, from the non-indigenous Brazilian population, these causes corresponded to 57.8%, 3.8%, and 2.8%, respectively. Indigenous people over 50 years of age died more from circulatory diseases (28.6%), respiratory diseases (15.4%), and neoplasms (14.6%), and in the remaining Brazilian population, these causes represented 31.5%, 13.6%, and 19.0%, respectively. Health inequalities and worse indicators among indigenous peoples in Brazil are evident.