Aim The aim of this study is to report two cases of post-surgical ciliated cysts (PSCC) in patients from Brazil with a history of trauma in the maxillary zygomatic suture region and traumatic tooth extraction. Additionally, we conducted a literature review of PSCC. Methods We reported two clinical cases of edentulous patients diagnosed with PSCC, including information on patients medical and surgical history. Furthermore, we performed a literature review, identifying previous cases of PSCC and compiling relevant information. Results In Case 1, the patient, a 64-year-old female, was edentulous and asymptomatic. The approach involved obtaining a panoramic radiograph, performing an incisional biopsy, followed by enucleation and curettage of the lesion. The patient is currently under follow-up, with no evidence of recurrence. In Case 2, the patient, a 61-year-old male, was also edentulous and had no painful symptoms. Imaging tests were ordered, and he subsequently underwent an excisional biopsy. Unfortunately, the follow-up was lost. According to the literature review, patient ages ranged from 17 to 76 years, with males comprising 52% and females 48% of the cases. Pain, swelling, and tenderness are common symptoms in the affected area. Le Fort I osteotomy was frequently associated with PSCC cases. Enucleation or curettage emerged as the predominant treatment approach for PSCC, demonstrating favorable outcomes with rare recurrences. Conclusion Considering the diagnosis of PSCC is crucial in patients with a history of prior maxillary surgeries. Additionally, a comprehensive patient history is imperative for the assessment of maxillary cystic lesions. postsurgical post (PSCC extraction Additionally Furthermore 1 64yearold yearold 64 year old female asymptomatic radiograph biopsy lesion followup, followup follow up, up recurrence 2 61yearold 61 male ordered Unfortunately lost 7 years 52 48 Pain swelling area recurrences surgeries lesions 6 5 4

ABSTRACT OBJECTIVES: To investigate the prevalence of sarcopenia according to five cut-off points for muscle strength and the association with undernutrition in Community dwelling older adults. METHODOLOGY: Cross-sectional study with 321 elderly subjects from community centers in Cuiabá-MT. The main variable was the prevalence of sarcopenia and association with undernutrition. Sarcopenia was diagnosed by low muscle strength (grip strength - GS; kg) according to five cut-off points and low calf circumference (CC; cm). Nutritional status was assessed by mini nutritional assessment-short form (MNA-SF®). RESULTS: The median age was 69 (64-74) years, and 24.7% were undernourished. The presence of sarcopenia ranged from 1.6 to 7.6%. This prevalence was lower using EWGSOP2 criteria compared to EWGSOP (p=0.005) and ESCEO and SDOC criteria (p<0.001). The older undernourished adults were almost 3.5 times more likely to have sarcopenia (OR=3.49; p=0.003) when ESCEO criteria was used and almost 2.5 times (OR=2.43; p=0.037) times using SDOC criteria. CONCLUSIONS: The prevalence of sarcopenia ranged from 1.6 to 7.6%. The older undernourished adults were almost 3.5 (ESCEO) and 2.5 (SDOC) times more likely to have sarcopenia.

RESUMO: Este estudo objetivou adaptar culturalmente, verificar a confiabilidade e sugerir um escore normativo do School Companion Sensory Profile 2 (SCSP-2) para crianças e jovens brasileiros de 3 a 14 anos e 11 meses. O SCSP-2 foi adaptado culturalmente para o Brasil seguindo as etapas de tradução inicial (dois tradutores independentes), tradução conciliada (dois integrantes do comitê técnico), análise de equivalência (quatro especialistas em integração sensorial), retrotradução (dois tradutores de língua materna inglesa), aprovação da autora e pré-teste. O pré-teste verificou a clareza e a compreensão (desdobramento cognitivo/validade de face) e a confiabilidade (equivalência interexaminadores, consistência interna e reprodutibilidade) da versão traduzida, com a participação de 74 professores que responderam ao questionário referente a 146 crianças. Os itens apresentaram índice de concordância acima de 75% no desdobramento cognitivo. A equivalência interexaminadores e teste-reteste apresentaram K ≥ 0,88 em todos os itens pesquisados. Observaram-se valores aceitáveis de consistência interna em quase todas as áreas sensoriais, quadrantes de procura sensorial e sensibilidade sensorial e no fator escolar 2. Os escores preliminares brasileiros são distintos dos americanos. O SCSP-2 adaptado para o Brasil apresenta evidências de validade baseada no conteúdo, além de boa consistência interna, possibilitando identificar problemas de processamento sensorial em crianças e jovens brasileiros. RESUMO SCSP2 SCSP (SCSP-2 1 meses SCSP- dois independentes, independentes , independentes) técnico, técnico técnico) quatro sensorial, sensorial) inglesa, inglesa inglesa) préteste. préteste pré teste. teste cognitivovalidade cognitivo face reprodutibilidade traduzida 7 75 testereteste reteste 088 0 88 0,8 pesquisados Observaramse Observaram se sensoriais americanos conteúdo (SCSP- 08 8 0, (SCSP

ABSTRACT: This study aimed to adapt culturally, verify the reliability, and suggest a normative score for the School Companion Sensory Profile 2 (SCSP-2) for Brazilian children and youths aged 3 to 14 years and 11 months. The SCSP-2 was culturally adapted for Brazil following the steps of initial translation (two independent translators), reconciled translation (two members of the technical committee), equivalence analysis (four experts in sensory integration), back-translation (two English mother tongue translators), author approval and pre-test. The pre-test verified the clarity and understanding (cognitive unfolding/face validity) and reliability (inter-examiner equivalence, internal consistency, and reproducibility) of the translated version, with the participation of 74 teachers who answered the questionnaire referring to 146 children. The items showed an agreement rate above 75% in cognitive unfolding/face validity. The inter-examiner and test-retest equivalence showed K ≥ 0.88 in all items surveyed. Acceptable internal consistency values were observed in almost all sensory areas, quadrants of sensory seeking and sensory sensitivity, and in the school factor 2. The Brazilian preliminary scores are different from the American ones. The SCSP-2 adapted for Brazil presents evidence of content-based validity and good internal consistency, making it possible to identify sensory processing problems in Brazilian children and youths. ABSTRACT SCSP2 SCSP (SCSP-2 1 months SCSP- two translators, translators , translators) committee, committee committee) four integration, integration integration) backtranslation back pretest. pretest pre test. test unfoldingface unfolding face interexaminer inter examiner reproducibility version 7 75 testretest retest 088 0 88 0.8 surveyed areas sensitivity ones contentbased content based (SCSP- 08 8 0. (SCSP

Resumo Muito se fala sobre 1968, “o ano que não terminou”. Revolta da juventude no mundo como um todo – e no Brasil também –, quebra de paradigmas, repulsa a velhos valores e, claro, intensificação do movimento estudantil, principalmente universitário. Mas, e antes de 1968? Os estudantes, que, antes deste ano, haviam “despertado”, passaram a primeira metade da década de 1960 adormecidos? Assim, este trabalho tem por objetivo analisar a organização política dos estudantes do ensino superior, especificamente da cidade de São Paulo, na famosa rua Maria Antônia, onde ficava a Faculdade de Filosofia, Ciências e Letras (FFCL) da Universidade de São Paulo (USP), entre 1964 e 1967. Os dados para a realização deste estudo são frutos de pesquisa de doutorado ainda em andamento, cujo objetivo é constituir uma biografia histórica de Iara Iavelberg (1944-1971), militante das organizações revolucionárias contra a ditadura civil-militar. 1968 o terminou. terminou . terminou” paradigmas claro estudantil universitário Mas despertado, despertado , “despertado” 196 adormecidos Assim superior Antônia Filosofia FFCL (FFCL USP, USP (USP) 1967 andamento 19441971, 19441971 1944 1971 (1944-1971) civilmilitar. civilmilitar civil militar. militar civil-militar “despertado 19 (USP 1944197 194 197 (1944-1971 1 194419 (1944-197 19441 (1944-19 (1944-1 (1944- (1944 (194 (19 (1 (

Abstract Much is said about 1968, “the year that did not end.” Youth rebellion in the whole world – and Brazil as well – paradigms being broken, repulsion to old values, and of course, intensification of the student movement, mainly in universities. But what about before 1968? Did the “awakened” students in 1968 spend the first half of the 1960s asleep? This article aims to analyze the political organization of university students, specifically from São Paulo city, on the famous Maria Antonia Street, where the Faculdade de Filosofia, Ciências e Letras (FFCL) of the Universidade de São Paulo (USP) was located from 1964 to 1967. Data used in this article are the result of a Ph.D. research still in progress, aiming to write a historical biography of Iara Iavelberg (1944-1971), militant of revolutionary organizations against the civil-military dictatorship. end. end broken values course movement universities awakened “awakened 196 s asleep city Street Filosofia FFCL (FFCL USP (USP 1967 PhD Ph D Ph.D progress 19441971, 19441971 1944 1971 , (1944-1971) civilmilitary civil military dictatorship 19 1944197 194 197 (1944-1971 1 194419 (1944-197 19441 (1944-19 (1944-1 (1944- (1944 (194 (19 (1 (

Resumo Violência e estressores psicossociais relacionados a experiências de discriminação por orientação sexual estão associados a resultados negativos para a saúde e à diminuição da expectativa de vida de mulheres lésbicas e bissexuais ao longo da vida. Este estudo teve por objetivo analisar a produção científica acerca da violência perpetrada contra mulheres homossexuais e bissexuais. A revisão integrativa abrangeu artigos publicados no período de 2006 a 2019, indexados nas bases PubMed, LILACS e PsycINFO, com base nos descritores em ciências da saúde: violência contra a mulher, homossexualidade feminina, bissexualidade, mulheres agredidas, saúde. Foram selecionados 11 artigos, a maioria com delineamento transversal, descritivo e quantitativo. Os resultados mostram que a população LGBT como um todo é recorrentemente submetida a vários tipos de violência, principalmente as mulheres que fazem parte desse segmento social, que são duplamente vitimizadas, uma vez que as manifestações violentas devido à orientação sexual são sobrepostas à violência de gênero. A violência contra as mulheres lésbicas e bissexuais representa um sério problema de saúde pública, agravada pelo fato de permanecer encoberta por um véu de invisibilidade.

Abstract Violence and psychosocial stressors related to experiences of discrimination based on sexual orientation are associated with negative health outcomes and decreased life expectancy of lesbian and bisexual women across the lifespan. This study aimed to analyze the scientific production regardind violence perpetrated against homosexual and bisexual women. The integrative review included articles published in the period 2006 to 2019, indexed in the PubMed, LILACS and PsycINFO databases, based on the descriptors in health sciences: violence against women, female homosexuality, bisexuality, battered women, health. Eleven articles were selected, most of them show cross-sectional, descriptive and quantitative design. The results show that the LGBT population as a whole is recurrently subjected to various types of violence, especially women who are part of this social segment, which are doubly victimized, since violent manifestations due to sexual orientation overlap with gender violence. Violence against lesbian and bisexual women represents a serious public health problem, aggravated by the fact that it remains hidden by a veil of invisibility.

Abstract Introduction: research shows the potential effect of vitamin D supplementation with an improvement in the glycemic profile of pre-diabetic patients. Objective: this study evaluates the effects of vitamin D supplementation on glycemic control markers in pre-diabetic individuals. Methods: we analyzed studies published over the last ten years, and indexed in the Science Direct, PubMed, and LILACS databases. We searched studies using health descriptors related to vitamin D, pre-diabetes, and glycemic control markers. We considered randomized controlled trials eligible for inclusion. All phases of selection, data extraction, and risk of bias assessment were carried out by two independent evaluators. Results: we identified 309 articles, of which 4 met the inclusion criteria. Of these, 3 studies have shown that vitamin D supplementation does not alter glycemic control markers in pre-diabetic individuals. Only one study showed a positive effect after supplementation with 60,000 IU/month of vitamin D3 for 12 months, with a significant reduction in the concentrations of glycated hemoglobin, fasting glucose, and two-hour postprandial glucose. Conclusion: there is insufficient scientific evidence to confirm the beneficial effects of vitamin D supplementation on glycemic control markers in pre-diabetic individuals.

Resumen Introducción: las investigaciones muestran el efecto potencial de la suplementación con vitamina D con una mejora del perfil glucémico de los pacientes prediabéticos. Objetivo: este estudio evalúa los efectos de la suplementación con vitamina D sobre los marcadores de control glucémico en personas prediabéticas. Métodos: analizamos los estudios publicados en los últimos diez años e indexados en las bases de datos Science Direct, PubMed y LILACS. Se realizaron búsquedas de estudios mediante descriptores de salud relacionados con la vitamina D, la prediabetes y los marcadores de control glucémico. Los ensayos controlados y aleatorizados se consideraron elegibles para su inclusión. Todas las fases de selección, extracción de datos y evaluación del riesgo de sesgos fueron realizadas por dos evaluadores independientes. Resultados: identificamos 309 artículos, de los que 4 cumplieron los criterios de inclusión. De estos, 3 estudios demostraron que la suplementación con vitamina D no altera los marcadores de control glucémico en las personas prediabéticas. Solo un estudio mostró un efecto positivo después de la suplementación de 60.000 UI/mes de vitamina D3 durante 12 meses, con una reducción significativa de las concentraciones de hemoglobina glucosilada, glucosa en ayunas y glucosa posprandial a las dos horas. Conclusión: no hay evidencia científica suficiente para confirmar los efectos beneficiosos de la suplementación de vitamina D sobre los marcadores de control glucémico en las personas prediabéticas.

Abstract: The aim of this study was to obtain estimates of genetic parameters via meta-analysis and mixed models to evaluate the potential of the germplasm from Embrapa Pecuaria Sudeste for integration in breeding programs. Data on the dry matter yield of 77 accessions evaluated in 24 harvests were used. Descriptive analysis was performed for mixed model and meta-analytical estimates. The variances for each parameter were estimated. For the meta-analysis, variances were used as weighting measures, and the fixed and random models were tested. A diagonal structure was considered for the residual variance matrix. Mean dry matter yield ranged from 1019.5 to 2684 kg ha-1. The phenotypic, permanent environmental, and genotypic variances oscillated widely throughout the harvests, as well as heritability. Meta-analytical estimates proved to be an accurate and complementary approach to the mixed model analysis. Both mixed model and meta-analytical estimates indicated the breeding potential of the alfalfa germplasm.

It is herein described the synthesis of a series of thirty novel 1,2,3-triazole-1,4 disubstituted compounds inspired on the known SRPKs inhibitor N-(2-(piperidin-1-yl)-5-(trifluoromethyl)phenyl)isonicotinamide (SRPIN340) and biological evaluation of them against human glioblastoma multiforme cell line U87MG. Starting with 1-fluoro-2 nitro-4-(trifluoromethyl)benzene (1), the substances were prepared via a five-step synthetic route. The crucial step corresponded to the copper-catalyzed cycloaddition reaction between trifluoromethyl phenyl azides and different alkynes. In general, the compounds were obtained with good yields and they were characterized utilizing spectroscopic (IR and NMR) and spectrometric (HRMS) techniques. The evaluation of the synthesized compounds at three different treatment time (24 h, 48 h, and 72 h) and concentrations (50, 100, and 150 µmol L-1) revealed that five derivatives were capable of reducing cell viability by 50% after 72 h of treatment at the highest concentration. On the contrary, three derivatives significantly increased cell viability being this effect more pronounced after 48 h of treatment. In this regard, it stands out the compound 2-((1-(2-morpholino-5-(trifluoromethyl)phenyl)-1H-1,2,3-triazol-4-yl)methyl)isoindoline-1,3-dione (7) which increased cell viability in approximately 300% after 48 h of treatment at 100 µmol L-1. The substances that increased cell viaiblity present as common structural features the presence of a saturated nitrogen-containing six-membered ring and carbonylated fragments.

BACKGROUND Treatment of mycoses is often ineffective, usually prolonged, and has some side effects. These facts highlight the importance of discovering new molecules to treat fungal infections. OBJECTIVES To search the Medicines for Malaria Venture COVID Box for drugs with antifungal activity. METHODS Fourteen human pathogenic fungi were tested against the 160 drugs of this collection at 1.0 µM concentration. We evaluated the ability of the drugs to impair fungal growth, their fungicidal nature, and morphological changes caused to cells. FINDINGS Thirty-four molecules (21.25%) presented antifungal activity. Seven are antifungal drugs and one is the agricultural fungicide cycloheximide. The other drugs with antifungal activity included antibiotics (n = 3), antimalarials (n = 4), antivirals (n = 2), antiparasitcs (n = 3), antitumor agents (n = 5), nervous system agents (n = 3), immunosuppressants (n = 3), antivomiting (n = 1), antiasthmatic (n = 1), and a genetic disorder agent (n = 1). Several of these drugs inhibited Histoplasma capsulatum and Paracoccidioides brasiliensis growth (15 and 20, respectively), while Fusarium solani was not affected by the drugs tested. Most drugs were fungistatic, but niclosamide presented fungicidal activity against the three dimorphic fungi tested. Cyclosporine affected morphology of Cryptococcus neoformans. MAIN CONCLUSIONS These drugs represent new alternatives to the development of more accessible and effective therapies to treat human fungal infections.

Resumen Objetivo: Este estudio tuvo por objetivo investigar la influencia del Partner Phubbing (Pphubbing) en el bienestar subjetivo y la satisfacción en las relaciones amorosas. Método: En el estudio participaron 217 personas con una media de edad de 25 años (min. 18, máx. 53 y dp = 5,98), siendo el 62,2 % del sexo femenino. Estos respondieron a las escalas de Pphubbing, afectos positivos y negativos, satisfacción con la vida, escala de satisfacción con la relación y cuestionario sociodemográfico. Los datos fueron analizados a través del SPSS (v.22). Resultados: Se encontró una correlación negativa y significativa entre el phubbing y los afectos positivos (r= -0,32, p<0,01), la satisfacción con la vida (r= -0,13; p<0,01) y la satisfacción con la relación (r= -0,38 p<0,01), como también presentó una correlación significativa, positiva y moderada entre el phubbing y los afectos negativos (r=0,33; p<0,01). A través de la regresión, el Pphubbing mostró influencia en la satisfacción con la relación (β=-0,38; p<0,001), afectos positivos (β=-0,32; p<0,001) y afectos negativos (β=0,33; p<0,001). Conclusiones: Los resultados sugieren que los participantes que sufren más phubbing de sus parejas tienden a tener menos satisfacción con la relación, así como menos bienestar subjetivo. Por lo tanto, este es un artículo con resultados inéditos para Brasil y uno de los pocos en el mundo en evaluar cuantitativamente el phubbing en las relaciones amorosas. De esta forma, contribuye al fomento de futuras investigaciones en el área y para el basamento de intervenciones y acciones de concientización acerca del uso saludable del Smartphone.

Abstract Objective: The objective of this study was to research partner phubbing´s influence (phubbing) on subjective well-being and romantic relationships’ satisfaction. Method: The study included 217 participants with a mean age of 25 years (minimum age = 18, maximum age 53, and dp = 5.98), 62,2 % being female. They responded to the phubbing scales, positive and negative effects, life satisfaction, relationship satisfaction scale, and sociodemographic questionnaire. The data were analyzed through the SPSS software (v.22). Results: A significant and negative correlation was found between phubbing and positive effects (r = −0.32, p < 0.01), life satisfaction (r = −0.13, p < 0.01), and relationship satisfaction (r = −0.38, p < 0.01), as it also presented a significant, positive, and moderate correlation between phubbing and negative effects (r = 0.33, p < 0.01). Through the regression, phubbing showed an influence on the relationship satisfaction (β = −0.38, p < 0.001), positive effects (β = −0.32, p < 0.001), and negative effects (β = 0.33, p < 0.001). Conclusions: The results suggest that those who experience more phubbing from their partners tend to be less satisfied with their relationship, as well as have less subjective well-being. Therefore, this article offers unprecedented results for Brazil, one of the few in the world to quantitatively evaluate phubbing in romantic relationships. In this way, it contributes to encouraging future research in the area and provides a basis for interventions and awareness actions regarding the healthy use of smartphone.

Resumo Objetivo: Este estudo teve por objetivo investigar a influência do Partner Phubbing (Pphubbing) no Bem-Estar subjetivo (BES) e na satisfação com o relacionamento. Método: Participaram 217 pessoas com média de idade de 25 anos (min. 18, máx. 53 e dp=5,98), sendo 62,2 % do sexo feminino. Estes responderam às escalas de Partner phubbing (Pphubbing), afetos positivos e negativos, satisfação com a vida, satisfação com o relacionamento e questionário sociodemográfico. Os dados foram analisados através do SPSS (v.22). Resultados: Foi encontrado uma correlação negativa entre Pphubbing e afetos positivos (r= -0,32; p<0,01), satisfação com a vida (r= -0,13; p<0,01) e satisfação com o relacionamento (r= -0,38 p<0,01), como também apresentou uma correlação positiva entre Pphubbing e afetos negativos (r=0,33; p<0,01). Através da regressão, o Pphubbing mostrou influência na satisfação com o relacionamento (β= -0,38; p<0,001), afetos positivos (β=-0,32; p<0,001) e afetos negativos (β=0,33; p<0,001). Conclusões: Os resultados sugerem que os participantes que sofrem mais phubbing de seus parceiros tendem a ter menos satisfação com o relacionamento, assim como menos Bem-Estar Subjetivo. Assim, este é um artigo com resultados inéditos para o Brasil e um dos poucos no mundo a avaliar quantitativamente o phubbing nos relacionamentos amorosos. Desta forma, contribui para o fomento de futuras pesquisas na área e para o embasamento de intervenções e ações de conscientização acerca do uso saudável do Smartphone.

Resumo Este trabalho relata uma experiência de extensão universitária que teve como objetivo integrar e divulgar os cursos de saúde da Universidade Estadual de Roraima (UERR), com foco em estudantes que estão concluindo o ensino médio ou cursando cursinhos pré-vestibulares. Os estudantes convidados têm a oportunidade de conhecer mais sobre os cursos da saúde, os professores, os alunos, as carreiras e a estrutura da UERR, servindo como um espaço de orientação profissional. O evento contou com a participação dos cursos de Medicina, Enfermagem, Educação Física e Ciências Biológicas da UERR através de dez estações onde os visitantes poderiam conhecer um pouco mais sobre os cursos, disciplinas e matérias relacionadas à área de saúde e biológicas.

Abstract This paper describes a university extension project aimed to integrate and promote the health courses at the Universidade Estadual de Roraima (State University of Roraima -UERR), focusing on students who are completing high school or taking university entrance exams courses. Participating students have the opportunity to learn more about the health courses, teachers, students, careers and structure of UERR, as a space for professional guidance. Students from UERR's Medical, Nursing, Physical Education and Biological Sciences courses attended the event. There were ten stands where visitors could learn a little more about the courses, disciplines and subjects related to the health and biological areas.

Resumen Este artículo expone una experiencia de extensión universitaria que tuvo como objetivo integrar y difundir los cursos de salud de la Universidad Estatal de Roraima (UERR), centrándose en los estudiantes que están terminando la enseñanza secundaria o haciendo cursos preuniversitarios. Los estudiantes invitados tienen la oportunidad de aprender más sobre los cursos de la salud, los profesores, los alumnos, las carreras y estructura de la UERR, sirviendo como un espacio de orientación profesional. El evento contó con la participación de los cursos de Medicina, Enfermería, Educación Física y Ciencias Biológicas de la UERR a través de diez estaciones donde los visitantes pudieron aprender un poco más sobre los cursos, asignaturas y temas relacionados con el área de salud y biología.

Résumé Ce travail présente une expérience d’activités d’extension universitaire visant à intégrer et à diffuser les filières de la santé de l’Universidade Estadual de Roraima (UERR), auprès d’élèves de terminale ou de cours préparatoires. À l’occasion de ces activités, les élèves ont l’opportunité d’apprendre davantage sur les cours, les enseignants, les étudiants, les carrières ainsi que sur la structure de l’UERR. Ces activités fonctionnent comme espace de conseil en orientation professionnelle. Les cours de médecine, de soins infirmiers, d’éducation physique et de sciences biologiques de l’UERR ont adhéré à l’activité et dix lieux ont été aménagés permettant aux visiteurs de savoir un peu plus sur les cours, les disciplines et les sujets liés au domaine de la santé et aux sciences biologiques.

RESUMO Objetivo: Investigar os efeitos do jejum noturno na força muscular de pacientes adultos internados. Métodos: Estudo clínico prospectivo realizado com 221 pacientes adultos. Os desfechos observados foram a força de preensão palmar avaliada pela dinamometria em jejum, após o desjejum, após o almoço, e acumulada (média da força de preensão palmar após desjejum e almoço). Foi considerada a média das três medidas da força de preensão palmar para representar cada momento. O ponto de corte para a média da força de preensão palmar em jejum categorizada no percentil 50 (35,5kg para homens, e 27,7kg para mulheres) foi usado para as comparações. Investigaram-se idade, sexo, peso atual e habitual (kg), perda de peso (kg), diagnóstico de câncer, estado nutricional, frequência de idosos, sintomas do trato digestório, tipo de dieta oral e quantidade ingerida no jantar no dia anterior à mensuração da força de preensão palmar (ingestão zero, até 50%, <100 e 100%). Resultados: A força de preensão palmar após o jejum noturno foi menor que a força após o desjejum (31,1±8,7kg versus 31,6±8,8kg; p=0,01) e quando foi considerada a força acumulada (31,7±8,8kg; p<0,001). A força de preensão palmar em jejum foi maior para os pacientes que ingeriram 100% (33,2±9,1kg versus 30,4±8,4kg; p=0,03) e >50% do jantar (32,1±8,4kg versus 28,6±8,8kg; p=0,006). A análise multivariada mostrou que ingerir menos da metade do jantar, desnutrição grave e ser idoso foram fatores independentes para redução da força de preensão palmar em jejum. Conclusão: A função muscular ficou comprometida após jejum noturno em pacientes adultos internados para tratamento clínico, especialmente nos casos de baixa ingestão alimentar, desnutridos e idosos.

ABSTRACT Objective: To investigate the effects of overnight fasting on handgrip strength of adult inpatients. Methods: A prospective clinical study enrolling 221 adult patients. The endpoints were handgrip strength obtained by dynamometry in three time points (morning after an overnight fasting, after breakfast and after lunch) and the cumulative handgrip strength (mean of handgrip strength after breakfast and lunch) in the same day. The mean of three handgrip strength measures was considered to represent each time point. A cut-off for the mean overnight fasting handgrip strength at the 50th percentile (35.5kg for males and 27.7kg for females) was used for comparisons. We registered the age, sex, current and usual weight (kg), weight loss (kg), diagnosis of cancer, nutritional status, elderly frequency, digestive tract symptoms, type of oral diet, and the amount of dinner ingested the night before handgrip strength (zero intake, until 50%, <100% and 100%). Results: Handgrip strength evaluated after an overnight fasting (31.2±8.7kg) was lesser when compared with handgrip strength after breakfast (31.6±8.8kg; p=0.01), and with cumulative handgrip strength (31.7±8.8kg; p<0.001). Handgrip strength was greater in patients who ingested 100% (33.2±9.1kg versus 30.4±8.4kg; p=0.03) and above 50% of dinner (32.1±8.4kg versus 28.6±8.8kg; p=0.006). Multivariate analysis showed that ingesting below 50% of dinner, severe malnutrition, and elderly were independent factors for handgrip strength reduction after overnight fasting. Conclusion: The muscular function was impaired after an overnight fasting of adult patients hospitalized for medical treatment, especially for those with low ingestion, malnourished and elderly.

Resumen Objetivo: La quimioterapia es una terapia bastante utilizada en el tratamiento del cáncer infantil y, aunque eficaz, provoca efectos colaterales y exige una reestructuración de lo cotidiano. El objetivo del estudio es comprender el juego como estrategia para enfrentar el tratamiento de la quimioterapia en niños. Método: Estudio exploratorio con análisis cualitativo de datos. Participaron diez niños entre siete y doce años con cáncer, en tratamiento quimioterapéutico y hospitalizados. Fueron llevadas a cabo entrevistas semiestructuradas utilizando títeres como recurso facilitador de la comunicación. En el análisis de los datos, del tipo temática inductiva, se destacó la importancia del juego como facilitador del enfrentamiento a la quimioterapia. Resultados: Los niños se refirieron a la relevancia del juego para combatir el ocio y destacaron la importancia de un espacio lúdico, adaptado a las necesidades del tratamiento dentro del ambiente hospitalario. La actuación del terapeuta ocupacional y de voluntarios caracterizados como clowns (payasos) fue citada como diferencial en este contexto. Consideraciones Finales: Se destaca la importancia de inversión, por parte de la administración de los hospitales, en espacios y materiales lúdicos y en la contratación de personal cualificado para facilitar el juego en los niños hospitalizados.

Abstract Objective: Chemotherapy is frequently used in childhood cancer treatment and, although effective, it causes collateral effects and requires the restructuring of children's daily lives. The aim of this study is to understand the play as a strategy to cope with the chemotherapy treatment in children. Method: This is an exploratory study with qualitative data analysis. Participants were 10 children with cancer between 7 and 12 years old, undergoing chemotherapy and hospitalized. Semistructured interviews were held, using puppets as a resource to facilitate the communication. In the data analysis, with an inductive approach, the importance of play as a facilitator of the chemotherapy coping was highlighted. Results: The children referred to the relevance of playing as a resource against idle time and highlighted the importance of a space to play, adapted to the treatment needs, within the hospital environment. The activities of the occupational therapist and of volunteers characterized as clowns was cited as differential in this context. Final Considerations: The importance of hospital administrations' investment in play spaces and materials is underlined, as well as the hiring of qualified staff to facilitate the hospitalized children's playing.

Resumo Objetivo: A quimioterapia é uma terapêutica bastante utilizada no tratamento do câncer infantil e, embora eficaz, provoca efeitos colaterais e exige reestruturação do cotidiano. Este estudo tem o objetivo de compreender o brincar como estratégia para enfrentamento do tratamento quimioterápico em crianças. Método: Pesquisa exploratória, com análise qualitativa dos dados. Participaram 10 crianças entre 7 e 12 anos, com câncer, em tratamento quimioterápico e hospitalizadas. Realizou-se entrevistas semiestruturadas usando fantoches como recurso facilitador da comunicação. Na análise dos dados, do tipo temática indutiva, destacou-se a importância do brincar como facilitador do enfrentamento da quimioterapia. Resultados: As crianças referiram-se à relevância do brincar para combater à ociosidade e destacaram a importância de um espaço lúdico, adaptado às necessidades do tratamento, dentro do ambiente hospitalar. A atuação do terapeuta ocupacional e de voluntários caracterizados como palhaços foi citada como diferencial neste contexto. Considerações finais: Reforça-se a importância de investimento, por parte da administração dos hospitais, em espaços e materiais lúdicos e na contratação de pessoal qualificado para facilitar o brincar das crianças hospitalizadas.

RESUMO O melhoramento genético da alfafa para alimentação animal leva mais tempo do que para muitas outras culturas. Por isso, definir melhores métodos de seleção é importante para o sucesso do melhoramento da cultura. Objetivou-se utilizar métodos de seleção direta, indireta e simultânea, para a seleção de cultivares de alfafa, com base em características de produção e valor nutritivo. As características avaliadas foram subdivididas em dois grupos: produção e valor nutritivo. Os ganhos de seleção foram estimados por seleção direta, indireta e simultânea para cada grupo, considerando-se a seleção das 25 % melhores cultivares. As seleções direta e indireta entre as médias dos genótipos não são eficientes para fornecer as respostas desejáveis para todo o conjunto de características. Os resultados da seleção simultânea, utilizando-se o índice de Tai, forneceram uma distribuição de ganhos mais equilibrada para os conjuntos de características em todos os cortes. A seleção simultânea permitiu a identificação das cultivares 5681 e Verdor no primeiro corte, bem como a ProINTA Patricia no segundo corte, como superiores, nos dois grupos de características avaliadas.

ABSTRACT Alfalfa breeding aimed at trait improvement for livestock feed takes longer periods of time, if compared to many other crops. Therefore, better selection methods are necessary for the success of alfalfa breeding programs. Although knowing about selection methods is quite important, there is a notable lack of information, as regards successful solutions. This study aimed to use direct, indirect and simultaneous selection methods for selecting alfalfa cultivars, based on yield traits and nutritive value. The evaluated traits were subdivided into two groups: forage yield and nutritive value. Selection gains were estimated by direct, indirect and simultaneous selection for each group, considering the selection of the 25 % best cultivars. Direct and indirect selections among genotype averages are not efficient to provide the desirable responses to the whole set of traits. The results for simultaneous selection, using the Tai index, provided a more balanced gain distribution to the set of traits in all cuts. The simultaneous selection allowed the identification of the 5681 and Verdor cultivars in the first cut, as well as ProINTA Patricia in the second cut, as superior in the two groups of evaluated traits.