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In this study, we aimed to investigate the anticancer activity of the extract, fractions, and isolated compounds of the flowers of Fridericia platyphylla, and to characterize the bioactive compounds. The chemical diversity of the extracts and fractions was investigated using liquid chromatography coupled with high resolution mass spectrometry (LC-HRMS). We were able to annotate 26 compounds from the classes of flavones, flavonols, flavanones, isoflavones, and cinnamic acid and its derivatives. The dichloromethane fraction showed greater cytotoxicity at a concentration of 100 µg mL−1. In addition, the inhibitory concentrations of the dichloromethane fraction were 22.14 and 30.9 µg mL−1 for MCF-7 and MDA-MB-231 cell lines, respectively, and were capable of inhibiting tumor cell migration. Brachydins A and C were isolated from the dichloromethane fraction and showed the greatest cytotoxicity. The results obtained from this study show the potential biological effect of F. platyphylla flowers as a possible antitumor pharmacological agent. extract LCHRMS. LCHRMS LC HRMS . (LC-HRMS) 2 flavones flavonols flavanones isoflavones derivatives 10 mL1 mL 1 addition 2214 22 14 22.1 309 30 9 30. mL− MCF7 MCF 7 MCF- MDAMB231 MDAMB MDA MB 231 MDA-MB-23 lines respectively migration F agent (LC-HRMS 221 22. 3 MDAMB23 23 MDA-MB-2 MDAMB2 MDA-MB- MDA-MB

https://doi.org/10.21577/0103-5053.20240132

Early visual intervention, visual function analysis, and grating visual acuity outcomes in children with congenital Zika syndrome intervention analysis
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Tartarella, Marcia Beatriz

; Braga, Ana Paula

; Borges, Jean Hipolito M.

; Furtado, Rosana S.A. S.

; Diogo, Natalia Gomes

; Verçosa, Islane M. C.

; Tartarella-Nascimento, Eduarda

Arquivos Brasileiros de Oftalmologia

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2025, Volume 88 N. 1 elocation e2022-0375

Abstract: En | Text: En | PDF: En

ABSTRACT Purpose: This study aimed to assess grating visual acuity and functional vision in children with congenital Zika syndrome. Methods: Initial and final grating visual acuity was measured using Teller acuity cards. Cerebral vision impairment standardized tests were used to assess functional vision. Patients were referred to the early visual intervention program for visually disabled children. Neuroimaging was performed. Results: In this study, 10 children were included with an age range of 1-37 months. Eight patients presented with macular atrophic scars. Neuroimaging revealed microcephaly and cerebral abnormalities in all patients. Low vision and cerebral vision impairment characteristics were observed in all children. The final grating visual acuity in this group varied from 3.00 to 0.81 logMAR. Conclusions: The grating visual acuity test revealed low vision in all children with congenital Zika syndrome. Functional vision evaluation revealed cerebral vision impairment characteristics in all patients, who were referred to the early visual intervention program. Visual acuity improved in six children. Purpose syndrome Methods cards performed Results 1 137 37 1-3 months scars 300 3 00 3.0 081 0 81 0.8 logMAR Conclusions 13 1- 30 3. 08 8 0.

https://doi.org/10.5935/0004-2749.2022-0375

O perfil dos egressos de um mestrado profissional: uma contribuição para o entendimento da relação formação-trabalho no SUS
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Nascimento, Ana Paula do

; Cesse, Eduarda Ângela Pessoa

; Figueiró, Ana Cláudia

Saúde em Debate

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jun 2024, Volume 48 N. 141 elocation e8857

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

ABSTRACT This article presents the profile of graduates, the effects of training, and the professional trajectory of the Professional Master’s Course in Public Health graduates at the Aggeu Magalhaes Institute. Of the 99 invited graduates who completed the program between 2013-2020, 54 responded to a questionnaire applied through the Lime Survey software. The descriptive and cross-sectional study used absolute and relative frequency cross-tabulation variables in the analysis, with the instrument covering the following themes: identification of the graduate and program/course; professional activity before and at the end of the program and expectations; current employment status and formation effects; evaluation of the formative trajectory. Among the respondents, most are female, aged between 31-40 years, trained as nurses, self-declared as black or brown-skinned, not having a disability, predominantly residing in Pernambuco, and did not enter through a quota system. As an effect on their professional life, it was found that the program increased prestige/recognition among colleagues, qualified them for activities they were already performing and also different activities, and brought salary increases leading to changes in personal and professional lives. The results are consistent with scientific findings in the same context, and the tool developed by FIOCRUZ made it possible to understand the relationship between education and work.

RESUMO Este artigo apresenta perfil dos egressos, efeitos da formação e trajetória profissional dos concluintes do Curso de Mestrado Profissional em Saúde Pública, do Instituto Aggeu Magalhães, parte de pesquisa avaliativa em desenvolvimento. Dos 99 egressos convidados que concluíram seus cursos entre 2013-2020, 54 responderam a um questionário aplicado por meio do software Lime Survey. O estudo descritivo e transversal utilizou frequência absoluta e relativa e cruzamento de variáveis na análise, cujo instrumento constou dos temas: identificação do egresso e do programa/curso; atividade profissional antes e ao término do curso e expectativas; condição empregatícia atual e efeitos da formação; avaliação da trajetória formativa. Entre os respondentes, a maioria é do sexo feminino, com idade entre 31-40 anos, enfermeiros de formação, autodeclarados pretos ou pardos, não ser pessoa com deficiência, predominantemente residentes em Pernambuco e não ingressaram mediante cota. Como efeito na vida profissional, encontrou-se que o curso aumentou o prestígio/reconhecimento dos colegas, qualificou para atividades que já exerciam e para atividades diferentes, e trouxe ganhos de remuneração, proporcionando mudanças na vida pessoal e profissional. Os resultados estão em conformidade com achados científicos desse mesmo contexto, e a ferramenta desenvolvida pela Fiocruz permitiu conhecer a relação entre formação e trabalho.

https://doi.org/10.1590/2358-289820241418857p

O perfil dos egressos de um mestrado profissional: uma contribuição para o entendimento da relação formação-trabalho no SUS profissional formaçãotrabalho formação trabalho
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Nascimento, Ana Paula do

; Cesse, Eduarda Ângela Pessoa

; Figueiró, Ana Cláudia

Saúde em Debate

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jun 2024, Volume 48 N. 141 elocation e8857

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.1590/2358-289820241418857p

Aurantiochytrium sp. and Nannochloropsis spp. meals as substitutes for fish oil in practical diets for Pacific white shrimp Penaeus vannamei
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Martins Guimarães, Ariane

; Mattioni, Bruna

; Miranda, Camilla Souza

; Morais, Ana Paula Mariane

; da Rosa Coelho, Jaqueline

; Fracalossi, Débora Machado

; do Vale Pereira, Gabriella

; do Nascimento Vieira, Felipe

Latin american journal of aquatic research

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may 2024, Volume 52 N. 2 Pages 209 - 219

Abstract: En | Text: En | PDF: En

ABSTRACT This study aimed to evaluate the use of microalgae meal (Aurantiochytrium sp. and Nannochloropsis spp.) as a substitute for fish oil in the diet of shrimp Penaeus vannamei reared in a clear water system. In the diet of these animals, the concentration of fish oil decreased as microalgae meal was inserted, and these were used in five different substitutions: 0, 25, 50, 75, and 100%. The treatments were carried out in triplicate, and after 49 days of cultivation, the zootechnical parameters and the composition of fatty acids in the animals’ muscles were analyzed. In zootechnical performance, the shrimp obtained an average final weight of 16.59 ± 0.3 g, and the growth was approximately 1.89 ± 0.30 g week−1. In addition, feed conversion was, on average, 1.47 ± 0.28, and survival was greater than 97%. However, no significant difference was observed in these parameters. Regardless of the levels of fish oil replacement by microalgae meal, the composition of fatty acids in the shrimp muscle was ensured, as well as their quantity within groups, such as n-3 and n-6 polyunsaturated fatty acids. Thus, with the results obtained in the present study, it is suggested that it is possible to formulate a high-performance diet without any ingredients of marine origin (fish oil or fish meal), contributing to aquaculture's sustainability.

https://doi.org/10.3856/vol52-issue2-fulltext-3101

Creation of a self-guided course about oral cancer for Community Health Workers: A Teleeducation experience
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Santos, Bruna Peixoto Nogueira dos

; Silveira, Márcia Maria Fonseca da

; Santos, Rebeka Thiara Nascimento dos

; Farias, Zilda Betânia Barbosa Medeiros de

; Almeida, Híttalo Carlos Rodrigues de

; Sobral, Ana Paula Veras

Physis: Revista de Saúde Coletiva

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2024, Volume 34 elocation e34067

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract Objective: To report the experience of creating and providing a self-instructional course about oral cancer, in a Telehealth platform, to Community Health Workers, and to analyze the participants’ clinic and demographic profile. Methods: Descriptive cross-sectional study of development and implementing experience of a course carried on a virtual learning environment, based on ADDIE, an Instructional Design model. The Kolmogorov-Smirnov test was applied, with 95% confidence level for quantitative variables. Results: The initial stage consisted of constructing the online course. In the second stage, the course was provided in a virtual learning environment. The course "Abre a boca, meu povo! - O que você precisa saber sobre o câncer de boca” was provided to the target audience with a student’s guide, initial survey, four modules with video lessons, initial and final knowledge test, satisfaction evaluation and certificate. Simplicity, clarity and objectivity have been prioritised in the transmission of knowledge. The final sample comprised 205 Community Health Workers. The predominant profile consisted of professionals aged between 40 and 49 years, female, with more than 10 years of career. Conclusions: The course achieved its objectives, revealing a satisfactory number of professionals in its first edition.

Resumo Objetivo: Relatar a experiência da criação e disponibilização de curso autoinstrucional sobre câncer de boca, em plataforma de Telessaúde, para Agentes Comunitários de Saúde, e analisar o perfil clínico-demográfico dos participantes. Metodologia: Estudo transversal descritivo da experiência de implantação e desenvolvimento de curso realizado em ambiente virtual de aprendizagem, baseado em ADDIE, um modelo de Design Instrucional. Foi aplicado teste de normalidade de Kolmogorov-Smirnov, com 95% de confiança para variáveis quantitativas. Resultados: A primeira fase consistiu na construção do curso on-line. Na segunda fase, o curso foi disponibilizado em ambiente virtual de aprendizagem. O curso "Abre a boca, meu povo! - O que você precisa saber sobre o câncer de boca” foi disponibilizado ao público-alvo com um manual do aluno, enquete inicial, quatro módulos com videoaulas, testes de conhecimentos inicial e final, avaliação de satisfação e certificado. Simplicidade, clareza e objetividade foram priorizadas na transmissão dos conhecimentos. A amostra final foi composta por 205 Agentes Comunitários de Saúde. O perfil predominante foi de profissionais com idade entre 40 e 49 anos, do sexo feminino, com mais de 10 anos de carreira. Conclusões: O curso atingiu os objetivos propostos, revelando um quantitativo satisfatório de profissionais, em sua primeira edição.

https://doi.org/10.1590/s0103-7331202434067en

Racial inequalities in child vaccination and barriers to vaccination in Brazil among live births in 2017 and 2018: an analysis of a retrospective cohort of the first two years of life
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Boing, Antonio Fernando

; Boing, Alexandra Crispim

; França, Ana Paula

; Moraes, José Cássio de

; Silva, Adriana Ilha da

; Ramos Jr., Alberto Novaes

; França, Ana Paula

; Oliveira, Andrea de Nazaré Marvão

; Boing, Antonio Fernando

; Domingues, Carla Magda Allan Santos

; Oliveira, Consuelo Silva de

; Maciel, Ethel Leonor Noia

; Guibu, Ione Aquemi

; Mirabal, Isabelle Ribeiro Barbosa

; Barbosa, Jaqueline Caracas

; Lima, Jaqueline Costa

; Moraes, José Cássio de

; Luhm, Karin Regina

; Caetano, Karlla Antonieta Amorim

; Lima, Luisa Helena de Oliveira

; Antunes, Maria Bernadete de Cerqueira

; Teixeira, Maria da Gloria

; Teixeira, Maria Denise de Castro

; Borges, Maria Fernanda de Sousa Oliveira

; Queiroz, Rejane Christine de Sousa

; Gurgel, Ricardo Queiroz

; Barata, Rita Barradas

; Azevedo, Roberta Nogueira Calandrini de

; Oliveira, Sandra Maria do Valle Leone de

; Teles, Sheila Araújo

; Gama, Silvana Granado Nogueira da

; Mengue, Sotero Serrate

; Simões, Taynãna César

; Nascimento, Valdir

; Araújo, Wildo Navegantes de

Epidemiologia e Serviços de Saúde

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2024, Volume 33 N. spe2 elocation e20231216

Abstract: Es En Pt | Text: Es En Pt | PDF: Es | PDF: En | PDF: Pt

resumen está disponible en el texto completo

ABSTRACT Objective To describe timely vaccination completion and obstacles in the first 24 months of life in Brazil, examining associations with maternal race/skin color. Methods Study participants were 37,801 children born in 2017 and 2018 included in the National Immunization Coverage Survey. We calculated prevalence and 95% confidence intervals for timely vaccine completeness and obstacles at 5, 12 and 24 months of life, according to maternal race/skin color. Associations were analyzed using logistic regression. Results 7.2% (95%CI 6.3;8.2) of mothers faced difficulties in taking their children to be vaccinated, and 23.4% (95%CI 21.7;25.1) were not vaccinated when taken. These proportions were 75% (95%CI 1.25;2.45) and 97% (95%CI 1.57;2.48) higher, respectively, among Black mothers. At least one vaccination was delayed among 49.9% (95%CI 47.8;51.9) and 61.1% (95%CI 59.2;63.0) of children by 5 and 12 months, respectively. These rates were higher among Black/mixed race mothers. Conclusion There are racial inequalities in both the obstacles faced and in vaccination rates in Brazil.

RESUMO Objetivo Descrever a completude vacinal em tempo oportuno nos primeiros 24 meses de vida no Brasil e os obstáculos para vacinação, testando-se associações com raça/cor da pele materna. Métodos Fez-se coleta de informações sobre os nascidos em 2017 e 2018, constantes no Inquérito Nacional de Cobertura Vacinal. Foram calculados prevalência e intervalos de confiança de 95% de obstáculos à vacinação e completude vacinal em tempo oportuno aos 5 meses, primeiro e segundo ano, segundo raça/cor da pele materna. Empregou-se regressão logística para análise de associações. Resultados Analisaram-se dados de 37.801 crianças. Do total, 7,2% (IC95% 6,3;8,2) dos responsáveis enfrentaram dificuldades para levar seus filhos para vacinação e 23,4% (IC95% 21,7;25,1) das crianças não foram vacinadas, mesmo sendo levadas. Essas proporções foram 75% (IC95% 1,25;2,45) e 97% (IC95% 1,57;2,48) mais elevadas, respectivamente, entre pretas; e 49,9% (IC95% 47,8;51,9) e 61,1% (IC95% 59,2;63,0) das crianças tiveram atraso em alguma vacina até os 5 meses e o primeiro ano, respectivamente. Tais valores foram maiores entre pardas/pretas. Conclusão Há desigualdades raciais nos obstáculos enfrentados e na vacinação no Brasil.

https://doi.org/10.1590/s2237-96222024v33e20231216.especial2.en

Description of vaccination coverage and hesitancy obtained by epidemiological survey of children born in 2017-2018, in Belo Horizonte and Sete Lagoas, Minas Gerais, Brazil
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Simões, Taynãna César

; Campos Neto, Orozimbo Henriques

; França, Ana Paula

; Moraes, José Cássio de

; Silva, Adriana Ilha da

; Ramos Jr., Alberto Novaes

; França, Ana Paula

; Oliveira, Andrea de Nazaré Marvão

; Boing, Antonio Fernando

; Domingues, Carla Magda Allan Santos

; Oliveira, Consuelo Silva de

; Maciel, Ethel Leonor Noia

; Guibu, Ione Aquemi

; Mirabal, Isabelle Ribeiro Barbosa

; Barbosa, Jaqueline Caracas

; Lima, Jaqueline Costa

; Moraes, José Cássio de

; Luhm, Karin Regina

; Caetano, Karlla Antonieta Amorim

; Lima, Luisa Helena de Oliveira

; Antunes, Maria Bernadete de Cerqueira

; Teixeira, Maria da Gloria

; Teixeira, Maria Denise de Castro

; Borges, Maria Fernanda de Sousa Oliveira

; Queiroz, Rejane Christine de Sousa

; Gurgel, Ricardo Queiroz

; Barata, Rita Barradas

; Azevedo, Roberta Nogueira Calandrini de

; Oliveira, Sandra Maria do Valle Leone de

; Teles, Sheila Araújo

; Gama, Silvana Granado Nogueira da

; Mengue, Sotero Serrate

; Simões, Taynãna César

; Nascimento, Valdir

; Araújo, Wildo Navegantes de

Epidemiologia e Serviços de Saúde

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2024, Volume 33 N. spe2 elocation e20231188

Abstract: Es En Pt | Text: Es En Pt | PDF: Es | PDF: En | PDF: Pt

resumen está disponible en el texto completo

ABSTRACT Objective To describe vaccination coverage and hesitation for the basic children’s schedule in Belo Horizonte and Sete Lagoas, Minas Gerais state, Brazil. Methods Population-based epidemiological surveys performed from 2020 to 2022, which estimated vaccine coverage by type of immunobiological product and full schedule (valid and ministered doses), according to socioeconomic strata; and reasons for vaccination hesitancy. Results Overall coverage with valid doses and vaccination hesitancy for at least one vaccine were, respectively, 50.2% (95%CI 44.1;56.2) and 1.6% (95%CI 0.9;2.7), in Belo Horizonte (n = 1,866), and 64.9% (95%CI 56.9;72.1) and 1.0% (95%CI 0.3;2.8), in Sete Lagoas (n = 451), with differences between socioeconomic strata. Fear of severe reactions was the main reason for vaccination hesitancy. Conclusion Coverage was identified as being below recommended levels for most vaccines. Disinformation should be combated in order to avoid vaccination hesitancy. There is a pressing need to recover coverages, considering public health service access and socioeconomic disparities.

RESUMO Objetivo Descrever as coberturas e hesitação das vacinas do calendário básico infantil em Belo Horizonte e Sete Lagoas, Minas Gerais. Métodos Inquéritos epidemiológicos de base populacional realizados de 2020 a 2022, para estimar coberturas vacinais por tipo de imunobiológico e esquema completo (doses válidas e aplicadas) segundo estratos socioeconômicos, e os motivos de hesitação vacinal. Resultados A cobertura global com doses válidas e a hesitação vacinal de pelo menos uma vacina foram, respectivamente, de 50,2% (IC95% 44,1;56,2) e 1,6% (IC95% 0,9;2,7), em Belo Horizonte (n = 1.866), e de 64,9% (IC95% 56,9;72,1) e 1,0% (IC95% 0,3;2,8), em Sete Lagoas (n = 451), com diferenças entre os estratos. O receio de reações graves foi o principal motivo de hesitação vacinal. Conclusão Identificou-se coberturas abaixo do preconizado para a maioria das vacinas. A desinformação deve ser combatida, evitando-se a hesitação vacinal. Há necessidade premente de recuperar as coberturas, considerando acesso ao SUS e disparidades socioeconômicas.

https://doi.org/10.1590/s2237-96222024v33e20231188.especial2.en

Trabalhadoras sexuais no marco pandêmico brasileiro: efeitos em e relações com a saúde
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Calabria, Amanda de Mello

; Lorente, Nicolas

; Santos, Michel de Oliveira Furquim dos

; Azevedo, Ana Carolina Braga

; Carvalho, Paula Galdino Cardin de

; Barros, Daniel Dutra de

; Oliveira, Gizelle Aparecida

; Font, Océane Apffel

; Nascimento, Silvana de Souza

; Veras, Maria Amelia de Sousa Mascena

; Castro, Daniela Rojas

; Nieto Olivar, José Miguel

Cadernos de Saúde Pública

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2024, Volume 40 N. 9 elocation e00181123

Abstract: Pt Es En | Text: Pt Es En | PDF: Pt | PDF: Es | PDF: En

Resumo: Este trabalho apresenta os resultados do estudo Eu Quero é Mais! A Vida de Profissionais do Sexo Durante a Pandemia da COVID-19, integrante do programa de investigação comunitária EPIC. O estudo analisou os efeitos da pandemia nas vidas de trabalhadoras sexuais cis, trans e travestis em nove Unidades da Federação e 11 cidades brasileiras ao longo de 2020 e 2021. O artigo tem como foco o componente qualitativo do estudo baseado em entrevistas semiestruturadas realizadas de forma presencial e remota com 43 trabalhadoras sexuais, e seu cotejamento com o componente quantitativo. Os efeitos são analisados em relação com o marco pandêmico brasileiro, considerando as dimensões sociais, econômicas e políticas do vírus da COVID-19. Entre as temáticas chaves da análise, se destacam: casos de adoecimento, práticas localizadas de isolamento social, práticas de prevenção e gerenciamento de cuidado, vacinação individual e estratégias coletivas de vacinação. Compartilhamos também as respostas cotidianas e ativistas traçadas por trabalhadoras sexuais numa agenda política que se contrapõe à lógica individualista, familiarista, doméstica e neoliberal de isolamento, por meio de perspectivas comunitárias de cuidado, o que se desenhou como a única linha de ação em saúde para a categoria durante a pandemia. As ações coletivas reposicionam o trabalho sexual na interface entre a saúde pública e os direitos humanos e tomam como princípio os conhecimentos das ruas, desde os ativismos, e o poder de decisão delas próprias sobre seus corpos.

Resumen: Este trabajo presenta los resultados del estudio ¡Yo Quiero Más! La Vida de las Profesionales del Sexo Durante la Pandemia de la COVID-19, parte del programa de investigación comunitaria EPIC. El estudio analizó los efectos de la pandemia en la vida de trabajadoras sexuales cis, trans y travestis en 9 estados y 11 ciudades brasileñas a lo largo del 2020 y del 2021. El artículo se centra en el componente cualitativo del estudio basado en entrevistas semiestructuradas realizadas de forma presencial y remota a 43 trabajadoras sexuales y su comparación con el componente cuantitativo. Los efectos se analizan con relación al marco pandémico brasileño, considerando las dimensiones sociales, económicas y políticas del virus de la COVID-19. Entre las temáticas clave del análisis, destacan: casos de enfermedad, prácticas localizadas de aislamiento social, prácticas de prevención y gestión del cuidado, vacunación individual y estrategias colectivas de vacunación. Compartimos también las respuestas cotidianas y activistas esbozadas por las trabajadoras sexuales en una agenda política que se opone a la lógica individualista, familiarista, doméstica y neoliberal del aislamiento, por medio de perspectivas comunitarias de cuidado, lo que se diseñó como la única línea de acción en salud para la categoría durante la pandemia. Las acciones colectivas reposicionan el trabajo sexual en la interfaz entre la salud pública y los derechos humanos y toman como principio el conocimiento de la calle, desde el activismo, y su poder de decisión sobre sus cuerpos.

Abstract: This paper describes the results of the study I Want More! The Lives of Sex Workers During the COVID-19 Pandemic, which is part of the EPIC community research program. The study analyzed the effects of the pandemic on the lives of cis, trans and travesti sex workers in nine Brazilian states and 11 cities throughout 2020 and 2021. This article focuses on the qualitative component of the study, which was based on semi-structured, remote and face-to-face interviews carried out with 43 sex workers, and its comparison with the quantitative component. The effects are analyzed in relation to the Brazilian pandemic framework, considering the social, economic and political dimensions of the COVID-19 virus. Some of the key themes of the analysis are cases of illness, specific social isolation practices, prevention and care management practices, individual vaccination and collective vaccination strategies. We also share the daily and activist responses drawn up by sex workers in a political agenda that opposes the individualistic, familialist, domestic, and neoliberal logic of isolation by adopting community care perspectives, which was the only line of health action for this work category during the pandemic. Collective actions reposition sex work at the interface between public health and human rights and take as their principle the “street knowledge”, from activism, and the workers’ power of decision over their own bodies.

https://doi.org/10.1590/0102-311xpt181123

10.

Incomplete recovery of the CD4+/CD8+ ratio is associated with the late introduction of antiretroviral therapy among people living with HIV infection CD4CD8 CDCD CD4 CD8 CD CD4+/CD8 CD4CD CD4+/CD
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Prates, Gabriela da Silva

; Monteiro, Mariana Amelia

; Oliveira, Éricka Constantinov

; Nascimento, Najara Ataide de Lima

; Veiga, Ana Paula Rocha

; Ferreira, Mauricio Domingues

; Polis, Thales José Bueno

; Caetano, Gabriela Prandi

; Soares, Beatriz Rodrigues Pellegrina

; Magri, Marcello Mihailenko Chaves

; Pereira, Luisa Oliveira

; Fonseca, Luiz Augusto Marcondes

; Alves, Wagner Silva

; Duarte, Alberto José da Silva

; Casseb, Jorge Simão do Rosário

Revista do Instituto de Medicina Tropical de São Paulo

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2024, Volume 66 elocation e7

Abstract: En | Text: En | PDF: En

ABSTRACT Despite being subject to lower AIDS-related mortality rates and having a higher life expectancy, patients with HIV are more prone to develop non-AIDS events. A low CD4+/CD8+ ratio during antiretroviral therapy identifies people with heightened immune senescence and increased risk of mortality. In clinical practice, finding determinants of a low CD4+/CD8+ ratio may be useful for identifying patients who require close monitoring due to an increased risk of comorbidities and death. We performed a prospective study on the evolution of the CD4+/CD8+ ratio in 60 patients infected with HIV (80% males), who were subjected to two different antiretroviral regimens: early and deferred therapy. The initial CD4+/CD8+ ratio was ≤1 for 70% of the patients in both groups. Older age, CD4+ cell count at inclusion, Nadir CD8+T-cell count, and Initial CD4+/CD8+ ratio ≤ 1 were risk factors for lack of ratio recovery. In the multivariate analysis, a CD4+/CD8+ ratio > 1 at the start of the treatment was found to be a determinant factor in maintaining a CD4+/CD8+ ratio > 1. The nadir CD4+T-cell count was lower in the deferred therapy group (p=0.004), and the last CD4+/CD8+ ratio ≤1 was not associated with comorbidities. Ratio recovery was not associated with the duration of HIV infection, time without therapy, or absence of AIDS incidence. A greater improvement was observed in patients treated early (p=0.003). In contrast, the slope of increase was slower in patients who deferred treatment. In conclusion, the increase in the CD4+/CD8+ ratio occurred mostly for patients undergoing early strategy treatment and its extension did not seem to be related to previous HIV-related factors. AIDSrelated expectancy nonAIDS non events CD4CD8 CDCD CD4 CD8 CD CD4+/CD8 practice death 6 80% 80 (80 males, males , males) regimens 70 groups age inclusion CD8+Tcell CD8Tcell CDTcell CD8+T T analysis CD4+Tcell CD4Tcell CD4+T p=0.004, p0004 p p=0.004 0 004 (p=0.004) infection incidence p=0.003. p0003 p=0.003 . 003 (p=0.003) contrast conclusion HIVrelated CD4CD CD4+/CD 8 (8 7 Tcell CD8T CDT CD4T p000 p=0.00 00 (p=0.004 (p=0.003 ( p00 p=0.0 (p=0.00 p0 p=0. (p=0.0 p=0 (p=0. p= (p=0 (p= (p

https://doi.org/10.1590/s1678-9946202466007

11.

Hepatitis A vaccination coverage survey in 24-month-old children living in Brazilian capitals, 2020
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Moura, Winny Éveny Alves

; Caetano, Karlla Antonieta Amorim

; Lima, Juliana de Oliveira Roque e

; Campos, Lays Rosa

; Silva, Grazielle Rosa da Costa e

; Moraes, José Cássio de

; França, Ana Paula

; Domingues, Carla Magda Allan Santos

; Teixeira, Maria da Gloria Lima Cruz

; Teles, Sheila Araújo

; Silva, Adriana Ilha da

; Ramos Jr., Alberto Novaes

; França, Ana Paula

; Oliveira, Andrea de Nazaré Marvão

; Boing, Antonio Fernando

; Domingues, Carla Magda Allan Santos

; Oliveira, Consuelo Silva de

; Maciel, Ethel Leonor Noia

; Guibu, Ione Aquemi

; Mirabal, Isabelle Ribeiro Barbosa

; Barbosa, Jaqueline Caracas

; Lima, Jaqueline Costa

; Moraes, José Cássio de

; Luhm, Karin Regina

; Caetano, Karlla Antonieta Amorim

; Lima, Luisa Helena de Oliveira

; Antunes, Maria Bernadete de Cerqueira

; Teixeira, Maria da Gloria

; Teixeira, Maria Denise de Castro

; Borges, Maria Fernanda de Sousa Oliveira

; Queiroz, Rejane Christine de Sousa

; Gurgel, Ricardo Queiroz

; Barata, Rita Barradas

; Azevedo, Roberta Nogueira Calandrini de

; Oliveira, Sandra Maria do Valle Leone de

; Teles, Sheila Araújo

; Gama, Silvana Granado Nogueira da

; Mengue, Sotero Serrate

; Simões, Taynãna César

; Nascimento, Valdir

; Araújo, Wildo Navegantes de

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2024, Volume 33 N. spe2 elocation e20231162

Abstract: Pt Es En | Text: Pt Es En | PDF: Pt | PDF: Es | PDF: En

RESUMO Objetivo Estimar a cobertura vacinal da hepatite A em crianças de 24 meses e identificar fatores associados à ausência de vacinação. Métodos Inquérito em amostra estratificada por estratos socioeconômicos em capitais (2020-2022), com estimativa de cobertura e intervalos de confiança de 95% (IC95%) e análise de fatores pela razão de prevalência (RP) via regressão de Poisson. Resultados Nas 31.001 crianças, a cobertura da hepatite A foi de 88,1% (IC95% 86,8;89,2). Nos estratos socioeconômicos (A/B), a variável pais/responsáveis imigrantes foi associada à ausência de vacinação (RP = 1,91; IC95% 1,09;3,37); nos estratos C/D, crianças de cor amarela (RP = 4,69; IC95% 2,30;9,57), 4ª ordem de nascimento ou mais (RP = 1,68; IC95% 1,06;2,66), não frequentar creche/berçário (RP = 1,67; IC95% 1,24;2,24) e mãe com trabalho remunerado (RP = 1,42; IC95% 1,16;1,74) foram associadas à ausência de vacinação. Conclusão Cobertura da hepatite A abaixo da meta (95%), sugerindo-se considerar especificidades dos estratos sociais.

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ABSTRACT Objective To estimate hepatitis A vaccination coverage in 24-month-old children and identify factors associated with non-vaccination. Methods This was a survey involving a sample stratified by socioeconomic strata in capital cities (2020-2022), with coverage estimates and 95% confidence intervals (95%CI), the factor analysis was performed using the prevalence ratio (PR) by means of Poisson regression. Results Among 31,001 children, hepatitis A coverage was 88.1% (95%CI 86.8;89.2). Regarding socioeconomic strata (A/B), the variable immigrant parents/guardians was associated with non-vaccination (PR = 1.91; 95%CI 1.09;3.37); in strata C/D, children of Asian race/skin color (PR = 4.69; 95%CI 2.30;9.57), fourth-born child or later (PR = 1.68; 95%CI 1.06;2 .66), not attending daycare/nursery (PR = 1.67; 95%CI 1.24;2.24) and mother with paid work (PR = 1.42; 95%CI 1.16;1.74) were associated with non-vaccination. Conclusion Hepatitis A coverage was below the target (95%), suggesting that specificities of social strata should be taken into consideration.

https://doi.org/10.1590/s2237-96222024v33e20231162.en

12.

Reliability of information recorded on the National Immunization Program Information System
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Moraes, José Cássio de

; França, Ana Paula

; Guibu, Ione Aquemi

; Barata, Rita Barradas

; Silva, Adriana Ilha da

; Ramos Jr., Alberto Novaes

; França, Ana Paula

; Oliveira, Andrea de Nazaré Marvão

; Boing, Antonio Fernando

; Domingues, Carla Magda Allan Santos

; Oliveira, Consuelo Silva de

; Maciel, Ethel Leonor Noia

; Guibu, Ione Aquemi

; Mirabal, Isabelle Ribeiro Barbosa

; Barbosa, Jaqueline Caracas

; Lima, Jaqueline Costa

; Moraes, José Cássio de

; Luhm, Karin Regina

; Caetano, Karlla Antonieta Amorim

; Lima, Luisa Helena de Oliveira

; Antunes, Maria Bernadete de Cerqueira

; Teixeira, Maria da Gloria

; Teixeira, Maria Denise de Castro

; Borges, Maria Fernanda de Sousa Oliveira

; Queiroz, Rejane Christine de Sousa

; Gurgel, Ricardo Queiroz

; Barata, Rita Barradas

; Azevedo, Roberta Nogueira Calandrini de

; Oliveira, Sandra Maria do Valle Leone de

; Teles, Sheila Araújo

; Gama, Silvana Granado Nogueira da

; Mengue, Sotero Serrate

; Simões, Taynãna César

; Nascimento, Valdir

; Araújo, Wildo Navegantes de

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2024, Volume 33 N. spe2 elocation e20231309

Abstract: Pt Es En | Text: Pt Es En | PDF: Pt | PDF: Es | PDF: En

RESUMO Objetivo Analisar a confiabilidade dos registros no Sistema de Informação do Programa Nacional de Imunizações (SI-PNI) em uma subamostra de crianças incluídas no inquérito nacional de cobertura vacinal nas capitais brasileiras e no Distrito Federal, em 2020. Método Estudo de concordância entre registros nas cadernetas (doses e datas) e no SI-PNI para 4.050 crianças com esquema completo aos 24 meses. Resultados Foram localizados registros de 3.587 crianças no SI-PNI, havendo 11% (IC95%10,0;12,0) de perdas. A concordância total entre doses e datas nas duas fontes foi de 86% (IC95% 86,0;87,0), porém para cada dose e vacina a variação foi maior, com 32% de dados só em uma fonte. Conclusão Parte das informações não vem sendo adequadamente registrada, mas para os dados existentes nas duas fontes a discordância pode ser considerada pequena. O sub-registro de doses e crianças pode comprometer as estimativas de cobertura vacinal, alterando os dados do numerador e do denominador.

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ABSTRACT Objective To analyze the reliability of records held on the National Immunization Program Information System (SI-PNI) in a subsample of children included in the national vaccination coverage survey in Brazilian state capitals and Federal District in 2020. Methods This was a study of agreement between data recorded on vaccination cards (doses and dates) and on the SI-PNI for 4050 children with full coverage at 24 months. Results Data on 3587 children were held on the SI-PNI, with losses of 11% (95%CI: 10;12). Total agreement between doses and dates in the two sources was 86% (95%CI: 86;87), however taking each dose and vaccine individually, variation was greater, with 32% of data in only one source. Conclusion Part of the information was not recorded, but the discrepancy can be considered small. Nonetheless, underrecording of doses and children can compromise vaccination coverage estimates, altering the numerator and denominator data.

https://doi.org/10.1590/s2237-96222024v33e20231309.especial2.en

13.

Vaccination coverage and delay in vaccination of infants born in 2017 and 2018 in municipalities in the Southern region of Brazil: National Vaccination Coverage Survey 2020
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Luhm, Karin Regina

; Boing, Antonio Fernando

; Mengue, Sotero Serrate

; Daniel, Neiva de Souza

; Mélo, Tainá Ribas

; Farion, Raquel Jaqueline

; França, Ana Paula

; Moraes, José Cássio de

; Silva, Adriana Ilha da

; Ramos Jr., Alberto Novaes

; França, Ana Paula

; Oliveira, Andrea de Nazaré Marvão

; Boing, Antonio Fernando

; Domingues, Carla Magda Allan Santos

; Oliveira, Consuelo Silva de

; Maciel, Ethel Leonor Noia

; Guibu, Ione Aquemi

; Mirabal, Isabelle Ribeiro Barbosa

; Barbosa, Jaqueline Caracas

; Lima, Jaqueline Costa

; Moraes, José Cássio de

; Luhm, Karin Regina

; Caetano, Karlla Antonieta Amorim

; Lima, Luisa Helena de Oliveira

; Antunes, Maria Bernadete de Cerqueira

; Teixeira, Maria da Gloria

; Teixeira, Maria Denise de Castro

; Borges, Maria Fernanda de Sousa Oliveira

; Queiroz, Rejane Christine de Sousa

; Gurgel, Ricardo Queiroz

; Barata, Rita Barradas

; Azevedo, Roberta Nogueira Calandrini de

; Oliveira, Sandra Maria do Valle Leone de

; Teles, Sheila Araújo

; Gama, Silvana Granado Nogueira da

; Mengue, Sotero Serrate

; Simões, Taynãna César

; Nascimento, Valdir

; Araújo, Wildo Navegantes de

Epidemiologia e Serviços de Saúde

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2024, Volume 33 N. spe2 elocation e20231206

Abstract: Pt Es En | Text: Pt Es En | PDF: Pt | PDF: Es | PDF: En

RESUMO Objetivo Avaliar as coberturas vacinais e o atraso nas doses de vacinas em lactentes em seis municípios da região Sul do Brasil. Metodologia Inquérito Nacional de Cobertura Vacinal 2020, com lactentes nascidos vivos em 2017 e 2018, realizado entre setembro de 2020 e março de 2022. Foram avaliadas as coberturas de doses aplicadas, doses em dia e o tempo de atraso da aplicação. Resultados Para 4.681 lactentes analisados, as coberturas para vacinas indicadas até os 24 meses foram de 68,0% (IC95% 63,9;71,8) para doses aplicadas e 3,9% (IC95% 2,7;5,7) para doses em dia. A maioria das aplicações em atraso foi ≤ 3 meses. Para alguns reforços, 25% das aplicações atrasaram ≥ 6 meses. Conclusão Além da busca de faltosos às vacinas, são necessárias estratégias para estímulo ao cumprimento do esquema de vacinação nas idades preconizadas.

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ABSTRACT Objective To evaluate vaccination coverage and delay in vaccine dose administration in infants in six municipalities in the Southern region of Brazil. Methodology National Vaccination Coverage Survey 2020, with infants born alive in 2017 and 2018, carried out from September 2020 to March 2022. Coverage of doses administered, doses administered on time and delay in dose administration were evaluated. Results For 4681 infants analyzed, coverage for vaccines recommended up to 24 months was 68.0% (95%CI 63.9;71.8%) for doses administered and 3.9% (95%CI 2.7%;5.7%) for doses administered on time. Delay time for the majority of late vaccinations was ≤ 3 months. For some boosters, 25% of vaccine administration was delayed by ≥ 6 months. Conclusion In addition to tracking vaccine defaulters, strategies are needed to encourage compliance with the vaccination schedule at the recommended ages.

https://doi.org/10.1590/s2237-96222024v33e20231206.especial2.en

14.

Vaccination coverage survey by social stratum in children up to 24 months of age in Londrina, Paraná, Brazil, between 2021 and 2022
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Oliveira, Edmilson de

; Moraes, José Cássio de

; França, Ana Paula

; Silva, Adriana Ilha da

; Ramos Jr., Alberto Novaes

; França, Ana Paula

; Oliveira, Andrea de Nazaré Marvão

; Boing, Antonio Fernando

; Domingues, Carla Magda Allan Santos

; Oliveira, Consuelo Silva de

; Maciel, Ethel Leonor Noia

; Guibu, Ione Aquemi

; Mirabal, Isabelle Ribeiro Barbosa

; Barbosa, Jaqueline Caracas

; Lima, Jaqueline Costa

; Moraes, José Cássio de

; Luhm, Karin Regina

; Caetano, Karlla Antonieta Amorim

; Lima, Luisa Helena de Oliveira

; Antunes, Maria Bernadete de Cerqueira

; Teixeira, Maria da Gloria

; Teixeira, Maria Denise de Castro

; Borges, Maria Fernanda de Sousa Oliveira

; Queiroz, Rejane Christine de Sousa

; Gurgel, Ricardo Queiroz

; Barata, Rita Barradas

; Azevedo, Roberta Nogueira Calandrini de

; Oliveira, Sandra Maria do Valle Leone de

; Teles, Sheila Araújo

; Gama, Silvana Granado Nogueira da

; Mengue, Sotero Serrate

; Simões, Taynãna César

; Nascimento, Valdir

; Araújo, Wildo Navegantes de

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2024, Volume 33 N. spe2 elocation e20231393

Abstract: Pt Es En | Text: Pt Es En | PDF: Pt | PDF: Es | PDF: En

RESUMO Objetivo Analisar a cobertura vacinal segundo estrato social, em crianças até 24 meses de vida, residentes no município de Londrina (PR). Métodos Inquérito de base populacional, realizado entre em 2021 e 2022, em que se avaliou a cobertura vacinal e os aspectos sociodemográficos das mães e das famílias, através do teste qui-quadrado de Pearson. Resultados Em uma amostra de 456 crianças, a cobertura vacinal completa variou de acordo com o estrato social, sendo no estrato A de 36,0% (IC95% 26,8;57,8); no estrato B, de 59,5% (IC95% 26,1;86); no estrato C, de 66,2% (IC95% 51,7;78,1); e no estrato D, de 70,0% (IC95% 56,1;81,0). Conclusão A análise da cobertura vacinal indicou o estrato social A como o de maior risco para doenças prevenidas por vacinas.

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ABSTRACT Objective To analyze vaccination coverage according to social strata in children up to 24 months old, living in the municipality of Londrina (PR), Brazil. Methods This was a population-based survey conducted between 2021 and 2022, in which vaccination coverage and sociodemographic aspects of mothers and families were evaluated using Pearson’s chi-square test. Results In a sample of 456 children, complete vaccination coverage varied according to social strata, being 36.0% (95%CI 26.8;57.8); in stratum A; 59.5% (95%CI 26.1;86); in stratum B; 66.2% (95%CI 51.7;78.1); in stratum C; and 70.0% (95%CI 56.1;81.0) in stratum D. Conclusion The analysis of vaccination coverage indicated that social stratum A is at highest risk for vaccine-preventable diseases.

https://doi.org/10.1590/s2237-96222024v33e20231393.especial2.en

15.

Use of private vaccination services by infants in Brazilian municipalities: National Vaccine Coverage Survey 2020
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Burdinski, Ediane de Fátima Mance

; Denardin, Maiara Sulzbach

; Marins, Gisele

; Otero, Sandra Duran

; França, Ana Paula

; Moraes, José Cássio de

; Luhm, Karin Regina

; Silva, Adriana Ilha da

; Ramos Jr., Alberto Novaes

; França, Ana Paula

; Oliveira, Andrea de Nazaré Marvão

; Boing, Antonio Fernando

; Domingues, Carla Magda Allan Santos

; Oliveira, Consuelo Silva de

; Maciel, Ethel Leonor Noia

; Guibu, Ione Aquemi

; Mirabal, Isabelle Ribeiro Barbosa

; Barbosa, Jaqueline Caracas

; Lima, Jaqueline Costa

; Moraes, José Cássio de

; Luhm, Karin Regina

; Caetano, Karlla Antonieta Amorim

; Lima, Luisa Helena de Oliveira

; Antunes, Maria Bernadete de Cerqueira

; Teixeira, Maria da Gloria

; Teixeira, Maria Denise de Castro

; Borges, Maria Fernanda de Sousa Oliveira

; Queiroz, Rejane Christine de Sousa

; Gurgel, Ricardo Queiroz

; Barata, Rita Barradas

; Azevedo, Roberta Nogueira Calandrini de

; Oliveira, Sandra Maria do Valle Leone de

; Teles, Sheila Araújo

; Gama, Silvana Granado Nogueira da

; Mengue, Sotero Serrate

; Simões, Taynãna César

; Nascimento, Valdir

; Araújo, Wildo Navegantes de

Epidemiologia e Serviços de Saúde

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2024, Volume 33 N. spe2 elocation e20231203

Abstract: En Pt Es | Text: En Pt Es | PDF: En | PDF: Pt | PDF: Es

ABSTRACT Objective To characterize the use of private services in infant vaccination and assess vaccination coverage according to the service used. Methods : This was a national vaccination survey conducted in 2020 that estimated the use of private vaccination services and vaccination coverage among infants residing in state capitals and 12 inland municipalities. Results : Of the 37,801 participants, 25.1% (95%CI 23.2;27.2) used private services at least once, with higher proportions in capitals, larger cities and in the South and Southeast regions. Socioeconomic and demographic differences were identified among families, based on the service used. The coverage for the set of vaccines administered up to 24 months was 60.3% (95%CI 58.6;62.0) in the public service and 59.5% (95%CI 55.9;63.0) in private services, and up-to-date vaccines, 10.3% (95%CI 9.1;11.6) and 9.4% (95%CI 7.4;11.8), respectively. Conclusion The use of private services was frequent, with low coverage for the set of vaccines, regardless of the type of service used, especially for up-to-date vaccines.

RESUMO Objetivo Caracterizar a utilização dos serviços privados na vacinação de lactentes e avaliar as coberturas vacinais segundo serviço utilizado. Métodos Inquérito nacional de vacinação realizado em 2020 que estimou a utilização de serviços privados de vacinação e as coberturas vacinais de lactentes residentes nas capitais dos estados, no Distrito Federal e em 12 municípios do interior. Resultados Dos 37.801 participantes, 25,1% (IC95% 23,2;27,2) utilizaram alguma vez serviços privados, com maiores proporções em capitais, cidades de maior porte e regiões Sul e Sudeste. Identificaram-se diferenças socioeconômicas e demográficas nas famílias, segundo o serviço utilizado. A cobertura para o conjunto de vacinas aplicadas até 24 meses foi de 60,3% (IC95% 58,6;62,0) no serviço público e de 59,5% (IC95% 55,9;63,0) no privado, e das vacinas em dia, de 10,3% (IC95% 9,1;11,6) e 9,4% (IC95% 7,4;11,8), respectivamente. Conclusão A utilização dos serviços privados foi frequente, com baixas coberturas para o conjunto de vacinas, independentemente do tipo de serviço utilizado, especialmente para vacinas em dia.

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https://doi.org/10.1590/s2237-96222024v33e20231203.especial2.en

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