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ABSTRACT Objective To analyze vaccination coverage up to 24 months of age according to race/ skin color in the 2017-2018 live birth cohort in Natal, Rio Grande do Norte, Brazil. Methods Population-based survey conducted in 2020 and 2021. Vaccination coverage up to 24 months of age was estimated according to administered, valid and timely doses. Crude association of race/skin color was estimated by calculating the crude Prevalence Ratio and respective 95% Confidence Intervals, using Poisson regression. Results Of the 688 children in the selected cohort, there was greater coverage among Black children for administered doses (White 30.5%; Black 47.8%; 95%CI) and valid doses (White 25.8%; Black 40.1%; 95%CI), although without statistical significance, and lower coverage for timely doses, in the full schedule excluding yellow fever (PR = 0.21; 95%CI 0.04;0.90). Conclusion There was lower timely coverage among Black children compared to White children.

RESUMO Objetivo Analisar a cobertura vacinal até os 24 meses de vida, segundo raça/cor da pele, na coorte de nascidos vivos em 2017-2018 em Natal, Rio Grande do Norte. Métodos Inquérito de base populacional realizado em 2020 e 2021. Estimaram-se as coberturas vacinais até os 24 meses de idade, segundo doses aplicadas, válidas e oportunas. A associação bruta da raça/cor da pele foi estimada pelo cálculo da razão de prevalência bruta e respectivos intervalos de confiança de 95% (IC95%), utilizando-se regressão de Poisson. Resultados Das 688 crianças da coorte selecionadas, houve maior cobertura entre as crianças negras para as doses aplicadas (brancas 30,5%; negras 47,8%; IC95%) e válidas (brancas 25,8%; negras 40,1%; IC95%), sem significância estatística, e menor cobertura para as doses oportunas, no esquema completo sem febre amarela (RP = 0,21; IC95% 0,04;0,90). Conclusão Evidenciou-se menor cobertura oportuna entre crianças negras, comparadas com crianças brancas.

resumen está disponible en el texto completo

https://doi.org/10.1590/s2237-96222024v33e20231310.especial2.en

Lesão Miocárdica e Prognóstico em Pacientes Hospitalizados com COVID-19 no Brasil: Resultados do Registro Nacional de COVID-19 COVID19 COVID 19 COVID-1 Brasil COVID1 1 COVID-
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Barbosa, Hannah Cardoso

; Martins, Maria Auxiliadora Parreiras

; Jesus, Jordana Cristina de

; Meira, Karina Cardoso

; Passaglia, Luiz Guilherme

; Sacioto, Manuela Furtado

; Bezerra, Adriana Falangola Benjamin

; Schwarzbold, Alexandre Vargas

; Maurílio, Amanda de Oliveira

; Farace, Barbara Lopes

; Silva, Carla Thais Cândida Alves da

; Cimini, Christiane Corrêa Rodrigues

; Silveira, Daniel Vitorio

; Carazai, Daniela do Reis

; Ponce, Daniela

; Costa, Emanuel Victor Alves

; Manenti, Euler Roberto Fernandes

; Cenci, Evelin Paola de Almeida

; Bartolazzi, Frederico

; Madeira, Glícia Cristina de Castro

; Nascimento, Guilherme Fagundes

; Velloso, Isabela Vasconcellos Pires

; Batista, Joanna d’Arc Lyra

; Morais, Júlia Drumond Parreiras de

; Carvalho, Juliana da Silva Nogueira

; Ruschel, Karen Brasil

; Martins, Karina Paula Medeiros Prado

; Zandoná, Liege Barella

; Menezes, Luanna Silva Monteiro

; Kopittke, Luciane

; Castro, Luís César de

; Nasi, Luiz Antônio

; Floriani, Maiara Anschau

; Souza, Maíra Dias

; Carneiro, Marcelo

; Bicalho, Maria Aparecida Camargos

; Lima, Maria Clara Pontello Barbosa

; Godoy, Mariana Frizzo de

; Guimarães-Júnior, Milton Henriques

; Mendes, Paulo Mascarenhas

; Delfino-Pereira, Polianna

; Ribeiro, Raquel Jaqueline Eder

; Finger, Renan Goulart

; Menezes, Rochele Mosmann

; Francisco, Saionara Cristina

; Araújo, Silvia Ferreira

; Oliveira, Talita Fischer

; Oliveira, Thainara Conceição de

; Polanczyk, Carisi Anne

; Marcolino, Milena Soriano

Arquivos Brasileiros de Cardiologia

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2023, Volume 120 N. 2 elocation e20220151

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Fundamento As complicações cardiovasculares da COVID-19 são aspectos importantes da patogênese e do prognóstico da doença. Evidências do papel prognóstico da troponina e da lesão miocárdica em pacientes hospitalizados com COVID-19 na América Latina são ainda escassos. Objetivos Avaliar a lesão miocárdica como preditor independente de mortalidade hospitalar e suporte ventilatório mecânico em pacientes hospitalizados, do registro brasileiro de COVID-19. Métodos Este estudo coorte é um subestudo do registro brasileiro de COVID-19, conduzido em 31 hospitais brasileiros de 17 cidades, de março a setembro de 2020. Os desfechos primários incluíram mortalidade hospitalar e suporte ventilatório mecânico invasivo. Os modelos para os desfechos primários foram estimados por regressão de Poisson com variância robusta, com significância estatística de p<0,05. Resultados Dos 2925 pacientes [idade mediana de 60 anos (48-71), 57,1%], 27,3% apresentaram lesão miocárdica. A proporção de pacientes com comorbidades foi maior nos pacientes com lesão miocárdica [mediana 2 (1-2) vs. 1 (0-20)]. Os pacientes com lesão miocárdica apresentaram maiores valores medianos de peptídeo natriurético cerebral, lactato desidrogenase, creatina fosfoquinase, N-terminal do pró-peptídeo natriurético tipo B e proteína C reativa em comparação a pacientes sem lesão miocárdica. Como fatores independentes, proteína C reativa e contagem de plaquetas foram relacionados com o risco de morte, e neutrófilos e contagem de plaquetas foram relacionados ao risco de suporte ventilatório mecânico invasivo. Os pacientes com níveis elevados de troponina apresentaram um maior risco de morte (RR 2,03, IC95% 1,60-2,58) e suporte ventilatório mecânico (RR 1,87;IC95% 1,57-2,23), em comparação àqueles com níveis de troponina normais. Conclusão Lesão cardíaca foi um preditor independente de mortalidade hospitalar e necessidade de suporte ventilatório mecânico em pacientes hospitalizados com COVID-19. COVID19 COVID 19 COVID-1 doença escassos COVID19. 19. COVID19, 19, 3 cidades 2020 invasivo robusta p005 p 0 05 p<0,05 292 idade 6 4871, 4871 48 71 , (48-71) 57,1%, 571 57,1% 57 57,1%] 273 27 27,3 12 (1-2 vs 020. 020 20 . (0-20)] cerebral desidrogenase fosfoquinase Nterminal N terminal própeptídeo pró independentes RR 203 03 2,03 IC95 IC 1,602,58 160258 1,60 2,58 58 1,60-2,58 1,87IC95% 187IC95 1,87 87 1,87;IC95 1,572,23, 157223 1,57 2,23 23 1,57-2,23) normais COVID1 COVID- 202 p00 p<0,0 29 487 4 7 (48-71 57,1 5 27, (1- 02 (0-20) 2,0 IC9 602 1,602,5 16025 160 1,6 258 2,5 1,60-2,5 87IC95 1,87IC95 187IC9 187 1,8 8 1,87;IC9 572 1,572,23 15722 157 1,5 223 2,2 1,57-2,23 p0 p<0, (48-7 57, (1 (0-20 2, 1,602, 1602 16 1, 25 1,60-2, 87IC9 1,87IC9 187IC 18 1,87;IC 1,572,2 1572 15 22 1,57-2,2 p<0 (48- ( (0-2 1,602 1,60-2 87IC 1,87IC 1,572, 1,57-2, p< (48 (0- 1,60- 1,572 1,57-2 (4 (0 1,57-

Abstract Background Cardiovascular complications of COVID-19 are important aspects of the disease’s pathogenesis and prognosis. Evidence on the prognostic role of troponin and myocardial injury in Latin American hospitalized COVID-19 patients is still scarce. Objectives To evaluate myocardial injury as independent predictor of in-hospital mortality and invasive mechanical ventilation support in hospitalized patients, from the Brazilian COVID-19 Registry. Methods This cohort study is a substudy of the Brazilian COVID-19 Registry, conducted in 31 Brazilian hospitals of 17 cities, March-September 2020. Primary outcomes included in-hospital mortality and invasive mechanical ventilation support. Models for the primary outcomes were estimated by Poisson regression with robust variance, with statistical significance of p<0.05. Results Of 2,925 patients (median age of 60 years [48-71], 57.1% men), 27.3% presented myocardial injury. The proportion of patients with comorbidities was higher among patients with cardiac injury (median 2 [1-2] vs. 1 [0-2]). Patients with myocardial injury had higher median levels of brain natriuretic peptide, lactate dehydrogenase, creatine phosphokinase, N-terminal pro-brain natriuretic peptide, and C-reactive protein than patients without myocardial injury. As independent predictors, C-reactive protein and platelet counts were related to the risk of death, and neutrophils and platelet counts were related to the risk of invasive mechanical ventilation support. Patients with high troponin levels presented a higher risk of death (RR 2.03, 95% CI 1.60-2.58) and invasive mechanical ventilation support (RR 1.87, 95% CI 1.57-2.23), when compared to those with normal troponin levels. Conclusion Cardiac injury was an independent predictor of in-hospital mortality and the need for invasive mechanical ventilation support in hospitalized COVID-19 patients. COVID19 COVID 19 COVID-1 diseases disease s prognosis scarce inhospital hospital Registry 3 cities MarchSeptember March September 2020 variance p005 p 0 05 p<0.05 2925 925 2,92 6 4871, 4871 48 71 , [48-71] 571 57 57.1 men, men men) 273 27 27.3 12 [1-2 vs 02. 02 . [0-2]) peptide dehydrogenase phosphokinase Nterminal N terminal probrain pro Creactive C reactive predictors RR 203 03 2.03 95 1.602.58 160258 1.60 2.58 58 1.60-2.58 187 87 1.87 1.572.23, 157223 1.57 2.23 23 1.57-2.23) COVID1 COVID- 202 p00 p<0.0 292 92 2,9 487 4 7 [48-71 5 57. 27. [1- [0-2] 20 2.0 9 602 1.602.5 16025 160 1.6 258 2.5 1.60-2.5 18 8 1.8 572 1.572.23 15722 157 1.5 223 2.2 1.57-2.23 p0 p<0. 29 2, [48-7 [1 [0-2 2. 1.602. 1602 16 1. 25 1.60-2. 1.572.2 1572 15 22 1.57-2.2 p<0 [48- [ [0- 1.602 1.60-2 1.572. 1.57-2. p< [48 [0 1.60- 1.572 1.57-2 [4 1.57-

https://doi.org/10.36660/abc.20220151

COVID-19 outcomes in people living with HIV: Peering through the waves COVID19 COVID 19 COVID-1 HIV COVID1 1 COVID-
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Sales, Thaís Lorenna Souza

; Souza-Silva, Maíra Viana Rego

; Delfino-Pereira, Polianna

; Neves, João Victor Baroni

; Sacioto, Manuela Furtado

; Assis, Vivian Costa Morais de

; Duani, Helena

; Oliveira, Neimy Ramos de

; Sampaio, Natália da Cunha Severino

; Ramos, Lucas Emanuel Ferreira

; Schwarzbold, Alexandre Vargas

; Jorge, Alzira de Oliveira

; Scotton, Ana Luiza Bahia Alves

; Castro, Bruno Mateus de

; Silva, Carla Thais Cândida Alves da

; Ramos, Carolina Marques

; Anschau, Fernando

; Botoni, Fernando Antonio

; Grizende, Genna Maira Santos

; Nascimento, Guilherme Fagundes

; Ruschel, Karen Brasil

; Menezes, Luanna Silva Monteiro

; Castro, Luís César de

; Nasi, Luiz Antônio

; Carneiro, Marcelo

; Godoy, Mariana Frizzo de

; Nogueira, Matheus Carvalho Alves

; Guimarães Júnior, Milton Henriques

; Ziegelmann, Patricia Klarmann

; Almeida, Rafaela Charão de

; Francisco, Saionara Cristina

; Silveira Neto, Sidney Teodoro

; Araújo, Silvia Ferreira

; Avelino-Silva, Thiago Junqueira

; Aliberti, Márlon Juliano Romero

; Pires, Magda Carvalho

; Silva, Eduardo Sérgio da

; Marcolino, Milena Soriano

Clinics

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2023, Volume 78 elocation 100223

Abstract: En | Text: En | PDF: En

Abstract Objective To evaluate clinical characteristics and outcomes of COVID-19 patients infected with HIV, and to compare with a paired sample without HIV infection. Methods This is a substudy of a Brazilian multicentric cohort that comprised two periods (2020 and 2021). Data was obtained through the retrospective review of medical records. Primary outcomes were admission to the intensive care unit, invasive mechanical ventilation, and death. Patients with HIV and controls were matched for age, sex, number of comorbidities, and hospital of origin using the technique of propensity score matching (up to 4:1). They were compared using the Chi-Square or Fisher's Exact tests for categorical variables and the Wilcoxon for numerical variables. Results Throughout the study, 17,101 COVID-19 patients were hospitalized, and 130 (0.76%) of those were infected with HIV. The median age was 54 (IQR: 43.0;64.0) years in 2020 and 53 (IQR: 46.0;63.5) years in 2021, with a predominance of females in both periods. People Living with HIV (PLHIV) and their controls showed similar prevalence for admission to the ICU and invasive mechanical ventilation requirement in the two periods, with no significant differences. In 2020, in-hospital mortality was higher in the PLHIV compared to the controls (27.9% vs. 17.7%; p = 0.049), but there was no difference in mortality between groups in 2021 (25.0% vs. 25.1%; p > 0.999). Conclusions Our results reiterate that PLHIV were at higher risk of COVID-19 mortality in the early stages of the pandemic, however, this finding did not sustain in 2021, when the mortality rate is similar to the control group. COVID19 COVID 19 COVID-1 infection (202 2021. . 2021) records unit death sex comorbidities up 41. 41 4 1 4:1) ChiSquare Chi Square Fishers Fisher s study 17101 17 101 17,10 hospitalized 13 0.76% 076 0 76 (0.76% 5 IQR (IQR 43.064.0 430640 43.0 64.0 43 64 43.0;64.0 202 46.063.5 460635 46.0 63.5 46 63 46.0;63.5 (PLHIV differences inhospital 27.9% 279 27 9 (27.9 vs 17.7% 177 7 0.049, 0049 0.049 , 049 0.049) 25.0% 250 25 (25.0 25.1% 251 0.999. 0999 0.999 999 0.999) pandemic however group COVID1 COVID- (20 4:1 1710 10 17,1 0.76 07 (0.76 064 43.064. 43064 430 43. 640 64. 6 43.0;64. 20 063 46.063. 46063 460 46. 635 63. 46.0;63. 27.9 2 (27. 17.7 004 0.04 04 25.0 (25. 25.1 099 0.99 99 (2 4: 171 17, 0.7 (0.7 06 43.064 4306 43.0;64 46.063 4606 46.0;63 27. (27 17. 00 0.0 25. (25 09 0.9 ( 0. (0. 43.06 43.0;6 46.06 46.0;6 (0 43.0; 46.0;

https://doi.org/10.1016/j.clinsp.2023.100223

EFFECT OF ARTIFICIAL WEATHERING ON PHYSICAL AND MECHANICAL PROPERTIES OF WOOD
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Aquino, Vinicius Borges de Moura

; Bertolini, Marilia Silva

; Morais, Cesar Augusto Galvão de

; Almeida, Tiago Hendrigo

; Almeida, Diego Henrique

; Lahr, Francisco Antonio Rocco

; Christoforo, André Luis

Revista Árvore

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2021, Volume 45 elocation e4534

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Quando a madeira é exposta ao ar livre, uma combinação de fatores químicos e mecânicos e a radiação solar contribuem para o que se denomina intemperismo, sendo o principal agente de degradação nesse ambiente. Este trabalho tem como objetivo investigar o efeito do intemperismo artificial nas propriedades mecânicas e físicas de Eucalyptus sp. e de Cupiúba (Goupia glabra) simulando efeitos naturais do intemperismo. As amostras foram envelhecidas em câmara de radiação UV com controle de umidade e temperatura por 100, 200, 300 e 400 horas, considerando os ciclos de envelhecimento de acordo com ASTM G154 (2006). As propriedades da madeira investigadas foram valor convencional de resistência à flexão estática (fM), módulo de elasticidade à flexão estática (EM), resistência à compressão paralela à fibra (fc0) e dureza Janka (fH) de acordo com a ABNT NBT 7190 (1997). Os efeitos do intemperismo artificial nas propriedades da madeira foram avaliados por análise estatística com nível de significância de 5%. A maioria das propriedades da madeira investigadas não apresentou alterações significativas com o envelhecimento realizado, porém, observou-se diminuição dos valores absolutos das propriedades da madeira durante o processo de envelhecimento. Apenas o fH da madeira de Cupiúba envelhecida por 100 e 200 horas apresentou perda significativa de desempenho no nível de significância considerado, o que pode estar relacionado a alterações na superfície da madeira devido à exposição ao intemperismo.

ABSTRACT When wood is exposed outdoors, a combination of chemical and mechanical factors and solar radiation contribute to what is described as weathering, being the main degradation agent in this environment. This paper aims to investigate the effect of artificial weathering on mechanical and physical properties of Eucalyptus sp. and Cupiúba (Goupia glabra) woods simulating natural weathering effects. Samples were aged in UV radiation chamber with humidity and temperature control for 100, 200, 300 and 400 hours, considering aging cycles according to ASTM G154 (2006). Wood properties investigated were Conventional value of strength in static bending (fM), Modulus of elasticity in static bending (EM), strength in compression parallel to grain (fc0) and Janka Hardness (fH) according to ABNT NBT 7190 (1997). Effects of artificial weathering on wood properties were evaluated by statistical analysis at 5% significance level. Most of the wood properties investigated did not present significant changes with the aging performed, however, it was noted a decrease in the absolute values of the wood properties absolute values during the aging process. Only fH of Cupiúba wood aged for 100 and 200 hours presented significative performance loss at the significance level considered, which can be related to changes on the wood surface due to weathering exposure.

https://doi.org/10.1590/1806-908820210000034 102 downloads

Performance indicators system for a metallurgical project portfolio management
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Barbosa, Leandro César Mol

; de Oliveira, Paula Cristina Senra

; Cunha, João Paulo Nogueira

; Morais, Felipe Silva

Gestão & Produção

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2021, Volume 28 N. 4 elocation e5529

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo: Este artigo tem como objetivo relatar a implantação de um conjunto de indicadores aplicados ao controle de um portfólio de projeto, ressaltando as soluções encontradas para tratar os problemas práticos comuns a este tipo de aplicação. Para isto, foi realizado um estudo baseado no método de pesquisa-ação, em que os indicadores foram levantados e testados na prática. Os resultados obtidos apontam para a necessidade de sistemáticas integradas de controle de indicadores que permitam a observação dos desvios ou tendências por meio de fontes distintas. O uso de mais de uma fonte de análise revelou resultados positivos para o controle eficiente da carteira de projetos. Foi também verificada a necessidade da observação da capacidade real da equipe e de sua experiência no estabelecimento das métricas dos indicadores. Quanto maior o aproveitamento da experiência da equipe, menos a empresa se abdica de vivências passadas. Além disso, os resultados obtidos indicam a necessidade de manter uma sistemática de feedback das ações tomadas, de forma que a equipe possa ter conhecimento dos resultados reais da aplicação dos indicadores.

Abstract: This work aims to report the implementation of a set of indicators applied to a project portfolio control, highlighting the solutions found to manage the practical problems common to these issues. We conducted a study based on the research-action method to establish and test the indicators. Our results indicate the need for integrated systems of indicators control to investigate the deviations or trends by different sources. The adoption of more than one analysis source demonstrated positive results for the efficient management of the project portfolio. Moreover, we verified the need to observe the real team skills and their experience in establishing indicators metrics. Once the team know-how is improved, the company would hardly relinquish its past experiences. Also, the results obtained indicate the need to maintain systematic feedback of the actions taken so that the team might be aware of the outcomes of the indicators’ applications.

https://doi.org/10.1590/1806-9649-2020v28e5529 74 downloads

Docosahexaenoic acid in diluent for goat semen cryopreservation
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Souza, Rosiléia Silva

; Machado, William Morais

; França, Caline Santana da

; Mugabe, Lopes César

; Pinheiro, Emmanuel Emydio Gomes

; Carneiro, Isabella de Matos Brandão

; Rocha, Laiara Fernandes

; Barbosa, Larissa Pires

Animal Reproduction

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2021, Volume 18 N. 3 elocation e20210027

Abstract: En | Text: En | PDF: En

Abstract The effects of docosahexaenoic acid (DHA) in the diluent for cryopreservation of goat semen on seminal quality and the optimal levels to be used were evaluated. After collection, semen was pooled and physically evaluated, then divided into four aliquots with different DHA levels in the diluent: 0, 10, 20, and 30 ng mL-1. The semen was cryopreserved in a TK 3000® freezing machine and then thawed for assessment at 37 °C. Sperm motility and vigor, membrane integrity, acrosomal integrity, mitochondrial activity, and sperm chromatin compaction were evaluated after thawing. A completely randomized design was used. For normally distributed variables, ANOVA and regression analysis were used to test for differences between treatments, and for non-parametric data, the Kruskal Wallis test was used at the 5% significance level. There were no differences among groups in terms of membrane integrity, acrosomal integrity, or chromatin compaction. There was a decrease in class I mitochondrial activity with increasing DHA level (P<0.05), but no differences in classes II, III, and IV (P>0.05). The inclusion of 10 to 30 ng mL-1 of DHA in the diluent did not result in improvements in seminal quality parameters after thawing, with some impairment observed in the mitochondrial activity of the sperm cells.

https://doi.org/10.1590/1984-3143-ar2021-0027 29 downloads

Gridshell em madeira: aspectos teóricos e construtivos
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Molina, Julio Cesar

; Calil Neto, Carlito

; Fé, Anderson Diego da

; Freitas, Ulysses Martins

; Morais, Pablo Henrique de

; Matos, Gabriela da Silva

Ambiente Construído

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mar 2020, Volume 20 N. 1 Pages 277 - 295

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo As gridshells são estruturas leves, que permitem a obtenção de grandes vãos livres, além de uma ampla variedade de formas arquitetônicas. No entanto, no Brasil, não existem registros da construção desse tipo de estrutura (em caráter permanente) nem muitas informações bibliográficas sobre o seu comportamento estrutural. Neste manuscrito, são apresentados os principais aspectos teóricos, como também os detalhes de projeto e de construção de uma gridshell, construída em madeira, em escala real. Os custos de construção também foram relacionados neste caso. Na confecção da estrutura utilizou-se uma configuração de malha quadrangular plana, formada por ripas duplas de madeira de Lyptus (Classe D40), unidas ortogonalmente entre si por parafusos com diâmetro de 6,35 mm. A malha plana (com dimensões totais de 9 m x 9 m) foi deformada até a obtenção da forma curva desejada e, posteriormente, travada por contraventamentos diagonais. A bagagem de conhecimento adquirida como resultado dessa aplicação prática levou a um aperfeiçoamento significativo da ideia de projeto inicial, relacionada ao controle da forma da estrutura durante as fases de montagem e à otimização das estratégias executivas. As recomendações de construção aqui apresentadas enriquecerão a literatura nacional sobre o assunto tendo-se em vista a carência de textos dessa natureza.

Abstract Gridshells are light structures that allow the obtention of large spans, as well as the use of a wide variety of architectural shapes. However, in Brazil, there are no records of the construction of this type of structure, neither literature available on this type of structural composition. This paper presents the main theoretical aspects, as well as design and construction details of a gridshell built in wood in real scale. The construction costs are also reported. The structure was built by using a quadrangular flat mesh configuration, formed by double slatted Lyptus wood (Class D40), joined orthogonally, using 6.35 mm diameter screws. The plane mesh (with total dimensions of 9 m x 9 m) was bent until the desired curve was achieved. The system was subsequently locked by diagonal bracing elements. The knowledge obtained through this practical application led to a significant improvement in the original design idea related to controlling the shape of the structure during the building phase and the the optimisation of the executing strategies. The building recommendations presented in this paper will be a contribution to the scarce literature on the subject currently available in Brazil.

https://doi.org/10.1590/s1678-86212020000100374 1169 downloads

Stability-indicating HPLC-DAD method for the simultaneous determination of fluoroquinolone in combination with a non-steroidal anti-inflammatory drug in pharmaceutical formulation
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Araujo, Elaine de Oliveira

; Rosa, Aline Marques

; Amaral, Marcos Serrou do

; Sversut, Rúbia Adrieli

; Baroni, Adriano César de Morais

; Oliveira, Lincoln Carlos Silva de

; Kassab, Nájla Mohamad

Brazilian Journal of Pharmaceutical Sciences

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2020, Volume 56 elocation e17758

Abstract: En | Text: En | PDF: En

We developed and validated a stability-indicating assay method for the simultaneous determination of enrofloxacin and piroxicam in combination and in the presence of degradation products. Reverse-phase high-performance liquid chromatography analyses were carried out on a Vertisep C18 column and acetonitrile-water (48:52 v/v, pH 3.0) mobile phase with a 1.00 mL min−1 flow rate. The efficient chromatographic separation of these drugs and their forced degradation products was achieved in less than 5min with a peak purity match factor higher than 950. The method used showed linearity in the concentration ranges of 0.25 to 16.0 µg mL−1 for enrofloxacin (r = 0.9997) and 0.125 to 8.0 µg mL−1 for piroxicam (r = 0.9999) as well as precision (relative standard deviation lower than 2%), accuracy (mean recovery 100 ± 2%), and robustness, according to ICH (International Conference on Harmonization) and AOAC (Association of Official Analytical Chemists) guidelines. This method can simultaneously determine the combination of these drugs in a veterinary formulation and separate the drug peaks from their forced degradation products. Additionally, its optimized chromatographic conditions can contribute to the quality control of this formulation in pharmaceutical manufacturing plants and minimize waste from the organic solvent.

https://doi.org/10.1590/s2175-97902019000417758 1567 downloads

10.

Venom complexity of Bothrops atrox (common lancehead) siblings
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Hatakeyama, Daniela Miki

; Tasima, Lídia Jorge

; Bravo-Tobar, Cesar Adolfo

; Serino-Silva, Caroline

; Tashima, Alexandre Keiji

; Rodrigues, Caroline Fabri Bittencourt

; Aguiar, Weslei da Silva

; Galizio, Nathália da Costa

; Lima, Eduardo Oliveira Venancio de

; Kavazoi, Victor Koiti

; Gutierrez-Marín, Juan David

; Farias, Iasmim Baptista de

; Sant’Anna, Sávio Stefanini

; Grego, Kathleen Fernandes

; Morais-Zani, Karen de

; Tanaka-Azevedo, Anita Mitico

Journal of Venomous Animals and Toxins including Tropical Diseases

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2020, Volume 26 elocation e20200018

Abstract: En | Text: En | PDF: En

Abstract Background: Variability in snake venoms is a well-studied phenomenon. However, sex-based variation of Bothrops atrox snake venom using siblings is poorly investigated. Bothrops atrox is responsible for the majority of snakebite accidents in the Brazilian Amazon region. Differences in the venom composition of Bothrops genus have been linked to several factors such as ontogeny, geographical distribution, prey preferences and sex. Thus, in the current study, venom samples of Bothrops atrox male and female siblings were analyzed in order to compare their biochemical and biological characteristics. Methods: Venoms were collected from five females and four males born from a snake captured from the wild in São Bento (Maranhão, Brazil), and kept in the Laboratory of Herpetology of Butantan Intitute. The venoms were analyzed individually and as a pool of each gender. The assays consisted in protein quantification, 1-DE, mass spectrometry, proteolytic, phospholipase A2, L-amino acid oxidase activities, minimum coagulant dose upon plasma, minimum hemorrhagic dose and lethal dose 50%. Results: Electrophoretic profiles of male’s and female’s venom pools were quite similar, with minor sex-based variation. Male venom showed higher LAAO, PLA2 and hemorrhagic activities, while female venom showed higher coagulant activity. On the other hand, the proteolytic activities did not show statistical differences between pools, although some individual variations were observed. Meanwhile, proteomic profile revealed 112 different protein compounds; of which 105 were common proteins of female’s and male’s venom pools and seven were unique to females. Despite individual variations, lethality of both pools showed similar values. Conclusion: Although differences between female and male venoms were observed, our results show that individual variations are significant even between siblings, highlighting that biological activities of venoms and its composition are influenced by other factors beyond gender.

https://doi.org/10.1590/1678-9199-jvatitd-2020-0018 1232 downloads

11.

Imagens e narrativas do Bolsa Família: análise da retórica da grande imprensa
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Leite, Cristiane Kerches da Silva

; Fonseca, Francisco César Pinto da

; Holanda, Bruna de Morais

Revista de Administração Pública

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sep 2019, Volume 53 N. 5 Pages 879 - 898

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

Resumo Este artigo analisa a produção de narrativas, imagens e histórias causais construídas pela grande imprensa (jornais Folha de S. Paulo e O Estado de S. Paulo) acerca de importante política social: o Programa Bolsa Família (PBF). Tais narrativas decorrem de orientações teóricas de políticas públicas ainda pouco desenvolvidas no Brasil - as teorias pós-positivistas e cognitivas -, constituindo-se um esforço analítico inovador neste artigo. Avaliou-se a disputa pelo monopólio da imagem do PBF por meio do exame quantitativo e qualitativo de materiais jornalísticos no período entre 2003 e 2017. Em decorrência, formularam-se categorias de imagens (assistencialismo, insuficiência, marketing eleitoral e populismo), interpretadas pelas “teses” de Albert Hirschman e pelas tipologias de John Campbell. Concluiu-se haver desconexão entre as narrativas criadas pela grande imprensa, por um lado, e o sentimento público favorável ao programa e seus impactos, por outro, sobretudo derivados de inúmeros estudos avaliativos elaborados por diferentes comunidades epistêmicas relacionadas às políticas públicas, nacional e internacionalmente. Esta pesquisa corroborou a hipótese de que a grande imprensa agiu como ator político/ideológico que fez a resistência conservadora diante do avanço da agenda de direitos sociais no Brasil, ao reproduzir reiteradamente as teses conservadoras de Hirschman em seus argumentos e histórias causais.

Abstract This article analyzes the production of narratives, images, and causal stories constructed by the mainstream press (Folha de S. Paulo and O Estado de S. Paulo newspapers) on the Bolsa Família Program (PBF). These narratives are derived from theoretical orientations for public policies that are still underdeveloped in Brazil: the post-positivist and cognitive theories, which characterizes this article as an innovative analytical effort. The study assessed the dispute over image monopoly using quantitative and qualitative analysis of journalistic materials published between 2003 and 2017. As a result, categories of images were formulated (handouts, insufficiency, electoral marketing, and populism), interpreted by Albert Hirschman’s “theses” and John Campbell’s typologies. The study concluded that there is a disconnection between the narratives created by the mainstream press on the one hand, and the public sentiment favorable to the program and its impacts on the other. This is mainly derived from evaluative studies elaborated by different epistemic communities related to public policies, nationally and internationally. This research corroborated the hypothesis that the mainstream press acted as a political/ideological actor who did the conservative resistance challenging the advancement of the social rights agenda in Brazil, by repeatedly reproducing conservative theses listed in Hirschman in their arguments and causative stories.

Resumen Este artículo analiza la producción de narrativas, imágenes e historias causales construidas por la gran prensa (periódicos Folha de S. Paulo y O Estado de S. Paulo) acerca de una importante política social: el Programa Bolsa Familia (PBF). Tales narrativas provienen de orientaciones teóricas de políticas públicas aún poco desarrolladas en Brasil - teorías pospositivistas y cognitivas-, constituyéndose en un esfuerzo analítico innovador de este artículo. Se evaluó la disputa por el monopolio de la imagen del PBF mediante el examen cuantitativo y cualitativo de material periodístico del período 2003-2017. Como resultado, se formularon categorías de imágenes -asistencialismo, insuficiencia, marketing electoral y populismo-, interpretadas por las “tesis” de Albert Hirschman y por las tipologías de John Campbell. Se llegó a la conclusión de que había una desconexión entre las narrativas creadas por la gran prensa, por un lado, y el sentimiento público favorable al programa y sus impactos, por otro, derivado principalmente de numerosos estudios evaluativos elaborados por diferentes comunidades epistémicas relacionadas con las políticas públicas, a nivel nacional e internacional. Esta investigación corroboró la hipótesis de que la gran prensa actuó como un actor político/ideológico que hizo la resistencia conservadora en vista del avance de la agenda de derechos sociales en Brasil, al reproducir reiteradamente las tesis conservadoras listadas por Hirschman en sus argumentos e historias causales.

https://doi.org/10.1590/0034-761220180383 1274 downloads

12.

Crop productivity and soil quality after fertilization with liquid swine manure
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Rimoldi Tavanti, Renan Francisco

; Freddi, Onã da Silva

; Tavanti, Tauan Rimoldi

; Lorenzon, Kayane

; dos Santos, Igor de Morais

; Demicheli, Matheus

; Costa, Letícia Carolina

; Montanari, Rafael

; Breda, Carlos Cesar

Acta Agronómica

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jun 2018, Volume 67 N. 2 Pages 303 - 310

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract An unresolved question about the use of animal waste in agriculture is its effect on the physical and chemical attributes of soil, especially in commercial grain producing areas that have adopted direct seeding system (DSS). Aiming at contributing to the clarification of this question, we conducted a study in the mid-north region of the Mato Grosso state, Brazil, in a soybean and maize commercial area consolidated in DSS. Different doses of liquid swine manure (LSM) were applied and compared with NPK mineral fertilization. The aim of this study was to evaluate the physical and chemical quality of the soil and the productive potential of the soybean and maize crops under LSM doses and NPK fertilizer. Results indicated an increase in levels of K, P, Zn and Cu exchangeable with LSM fertilization of 80 m3.ha-1. Fertilizers with mineral NPK and LSM at 80 and 60 m3.ha-1, respectively, show soil porosity improvements and decreased soil penetration resistance. Moreover, the use of LSM also provided the highest increases in soybean and maize grain yield.

Resumo Uma das questões pouco esclarecidas sobre o uso de resíduos animais na agricultura, é seu efeito sobre os atributos físicos e químicos do solo, principalmente em áreas comerciais produtoras de grãos que adotam o sistema de semeadura direta (DSS). Visando contribuir com o esclarecimento desta questão, realizamos um estudo na região médio-norte do estado de Mato Grosso, Brasil, em uma área comercial de soja e milho consolidada em DSS. Aplicou-se diferentes doses de dejetos líquidos de suínos (LSM) e as comparou com adubação mineral NPK. O objetivo foi avaliar a qualidade física e química do solo e o potencial produtivo das culturas soja e milho sob as doses de LSM e NPK como fertilizantes. Os resultados indicaram aumento nos teores de K, P, Zn e Cu trocáveis com adubação de 80 m3 ha-1 de LSM. As adubações com fertilizante mineral NPK e LSM nas doses de 80 e 60 m3 ha-1 proporcionam melhorias na porosidade do solo e diminuíram a resistência do solo à penetração. O uso de LSM também proporcionou os maiores incrementos na produtividade de grãos de soja e de milho.

https://doi.org/10.15446/acag.v67n2.65684 473 downloads

13.

Pharmaceutical development of tablets containing a spray-dried optimized extract from Lippia origanoides H. B. K.: influence of excipients and toxicological assessment
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Coelho, Angélica Gomes

; Lima Neto, José de Sousa

; Moura, Arkellau Kenned Silva

; Morais, Ilmara Cecilia Pinheiro da Silva

; Cunha, Francisco Valmor Macedo

; Melo-Neto, Bernardo

; Medeiros, Maria das Graças Freire de

; Vasconcelos, Eilika Andreia Feitosa

; Arcanjo, Daniel Dias Rufino

; Nunes, Lívio Cesar Cunha

; Citó, Antônia Maria das Graças Lopes

Brazilian Journal of Pharmaceutical Sciences

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2018, Volume 54 N. 2 elocation e17226

Abstract: En | Text: En | PDF: En

ABSTRACT Lippia origanoides is a honey shrub which has showed hypotensive potential assessed by in vivo studies. The aim of this work is the development of a pharmaceutical formulation composed by an optimized extract obtained from aerial parts of L. origanoides. The quantification of the naringenin marker in the dry extract and tablets developed was performed, as well as the assessment of the oral acute toxicity in rats. The hydroalcoholic extract of L. origanoides was spray-dried with the addition of colloidal silicon dioxide (Lo-HAE/CSD), and then applied in the preparation of eight different lots of tablets. The influence of the diluent (cellulose or babassu mesocarp), the presence of binder, and the percentage of lubricant, as well as organoleptic and physicochemical characteristics were screened. For the quantification of the marker content both in Lo-HAE/CSD and in the tablets, an analytical curve of the naringenin standard was fitted, and the samples were then analyzed in UFLC. The toxicological assessment was performed in female Wistar rats according to the Acute Toxic Class Method from OECD. The developed tablets produced meet acceptable macroscopic characteristics, and the presence of babassu as diluent provided improved physicochemical properties. The best content of Lo-HAE/CSD in the tablet (100.27%) was identified for the lot containing babassu, composed by 1.0% magnesium stearate, without PVP binder in its formulation. Moreover, Lo-HAE/CSD showed no signs of toxicity. Therefore, the babassu mesocarp powder is a promising pharmaceutical excipient for the development of herbal tablets containing the Lippia origanoides extract.

https://doi.org/10.1590/s2175-97902018000217226 1465 downloads

14.

Home Blood Pressure Monitoring as an Alternative to Confirm Diagnoses of Hypertension in Adolescents with Elevated Office Blood Pressure from a Brazilian State Capital
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Póvoa, Thaís Inacio Rolim

; Jardim, Thiago Veiga

; Carneiro, Carolina de Souza

; Ferreira, Vanessa Roriz

; Mendonça, Karla Lorena

; Morais, Polyana Resende Silva de

; Nascente, Flávia Miquetichuc Nogueira

; Souza, Weimar Kunz Sebba Barroso de

; Sousa, Ana Luiza Lima

; Jardim, Paulo César Brandão Veiga

Arquivos Brasileiros de Cardiologia

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sep 2017, Volume 109 N. 3 Pages 241 - 247

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Fundamentos: São desconhecidas as diferenças regionais na utilização da monitorização residencial da pressão arterial (MRPA) como alternativa à monitorização ambulatorial da pressão arterial (MAPA) em adolescentes hipertensos. Objetivos: Definir se MRPA é uma opção para confirmar diagnóstico de hipertensão arterial em adolescentes de uma capital brasileira com pressão arterial (PA) elevada. Métodos: Adolescentes (12-18 anos) de escolas públicas e privadas com percentil de PA > 90 foram estudados para comparar e avaliar a concordância entre as medidas de PA, MRPA e MAPA. As medidas de PA de consultório, MRPA e MAPA foram realizadas de acordo com as recomendações das diretrizes. Foram utilizados dispositivos semiautomáticos para medições de PA. Valores de p <0,05 foram considerados significativos. Resultados: Foram incluídos 133 adolescentes predominantemente do sexo masculino (63,2%) com idade média de 15 ± 1,6 anos. Os valores médios da pressão arterial sistólica e pressão arterial diastólica da MRPA foram semelhantes aos valores de MAPA diurnos (120,3 ± 12,6 mmHg x 121,5 ± 9,8 mmHg - p = 0,111 e 69,4 ± 7,7 mmHg x 70,2 ± 6,6 mmHg - p = 0,139) e inferiores aos valores de consultório (127,3 ± 13,8 mmHg por 74,4 ± 9,5 mmHg - p < 0,001). Os gráficos de Bland-Altman mostraram boa concordância entre MRPA e MAPA. Conclusões: MRPA é uma opção para confirmar diagnóstico de hipertensão arterial em adolescentes de uma capital brasileira com PA de consultório elevada e pode ser usada como alternativa à MAPA.

Abstract Background: Regional differences of using home blood pressure monitoring (HBPM) as an alternative to ambulatory blood pressure monitoring (ABPM) in hypertensive adolescents are unknown. Objectives: Define if HBPM is an option to confirm diagnoses of hypertension in adolescents from a Brazilian capital with elevated office blood pressure (BP). Methods: Adolescents (12-18years) from public and private schools with BP > 90th percentile were studied to compare and evaluate the agreement among office BP measurements, HBPM and ambulatory BP monitoring. Office BP measurements, HBPM and ABPM were performed according to guidelines recommendations. Semi-automatic devices were used for BP measurements. Values of p < 0.05 were considered significant. Results: We included 133 predominantly males (63.2%) adolescents with a mean age of 15±1.6 years. HBPM systolic blood pressure and diastolic blood pressure mean values were similar to the daytime ABPM values (120.3 ± 12.6 mmHg x 121.5 ± 9.8 mmHg - p = 0.111 and 69.4 ± 7.7 mmHg x 70.2 ± 6.6 mmHg - p = 0.139) and lower than the office measurement values (127.3 ± 13.8 mmHg over 74.4 ± 9.5 mmHg - p < 0,001). The Bland-Altman plots showed good agreement between HBPM and ABPM. Conclusions: HBPM is an option to confirm diagnoses of hypertension in adolescents from a Brazilian state capital with elevated office BP and can be used as an alternative to ABPM.

https://doi.org/10.5935/abc.20170114 1670 downloads

15.

Design requirements of a human-powered planter
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Stefanello, Giusepe

; Machado, Antônio Lilles Tavares

; Reis, Ângelo Vieira dos

; Morais, César Silva de

; Oldoni, André

Ciência Rural

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2017, Volume 47 N. 6 elocation e20160743

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO: Este trabalho objetivou estabelecer os requisitos de clientes e de projeto de uma semeadora à tração humana. Foram estabelecidos 13 requisitos de clientes e 13 requisitos de projeto, priorizando o desempenho da semeadora, proporcionando benefícios aos seus usuários.

ABSTRACT: This study aimed to establish client and design requirements of a human-powered planter. A total of 13 client requirements and 13 design requirements were established for prioritizing planter performance, thus providing benefits to users.

https://doi.org/10.1590/0103-8478cr20160743 886 downloads

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