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ABSTRACT Objective: This study aimed to present a temporal and spatial analysis of the 2018 measles outbreak in Brazil, particularly in the metropolitan city of Manaus in the Amazon region, and further introduce a new tool for spatial analysis. Methods: We analyzed the geographical data of the residences of over 7,000 individuals with measles in Manaus during 2018 and 2019. Spatial and temporal analyses were conducted to characterize various aspects of the outbreak, including the onset and prevalence of symptoms, demographics, and vaccination status. A visualization tool was also constructed to display the geographical and temporal distribution of the reported measles cases. Results: Approximately 95% of the included participants had not received vaccination within the past decade. Heterogeneity was observed across all facets of the outbreak, including variations in the incubation period and symptom presentation. Age distribution exhibited two peaks, occurring at one year and 18 years of age, and the potential implications of this distribution on predictive analysis were discussed. Additionally, spatial analysis revealed that areas with the highest case densities tended to have the lowest standard of living. Conclusion: Understanding the spatial and temporal spread of measles outbreaks provides insights for decision-making regarding measures to mitigate future epidemics. Objective 201 Brazil region Methods 7000 7 000 7,00 2019 symptoms demographics status cases Results 95 decade presentation peaks 1 age discussed Additionally living Conclusion decisionmaking decision making epidemics 20 700 00 7,0 9 2 70 0 7,

https://doi.org/10.31744/einstein_journal/2024ao0931

Hand tumors
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Neder Filho, Antonio Tufi

; Costa, Antonio Carlos da

; Barros, Rui Sérgio Monteiro de

; Nakachima, Luis Renato

; Rodrigues, Mauricio Pinto

; Souza, Sandro Castro Adeodato de

; Oliveira, Ricardo Kaempf de

; Gama, Sérgio Augusto Machado da

; Sabongi, Rodrigo Guerra

; Hirakawa, Celso Kiyoshi

Revista da Associação Médica Brasileira

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2024, Volume 70 Suppl. 1 elocation e2024S108

Abstract: En | Text: En | PDF: En

https://doi.org/10.1590/1806-9282.2024s108

Diretriz Brasileira de Ergometria em População Adulta – 2024 202 20 2
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Carvalho, Tales de

; Freitas, Odilon Gariglio Alvarenga de

; Chalela, William Azem

; Hossri, Carlos Alberto Cordeiro

; Milani, Mauricio

; Buglia, Susimeire

; Precoma, Dalton Bertolim

; Falcão, Andréa Maria Gomes Marinho

; Mastrocola, Luiz Eduardo

; Castro, Iran

; Albuquerque, Pedro Ferreira de

; Coutinho, Ricardo Quental

; Brito, Fabio Sandoli de

; Alves, Josmar de Castro

; Serra, Salvador Manoel

; Santos, Mauro Augusto dos

; Colombo, Clea Simone Sabino de Souza

; Stein, Ricardo

; Herdy, Artur Haddad

; Silveira, Anderson Donelli da

; Castro, Claudia Lucia Barros de

; Silva, Miguel Morita Fernandes da

; Meneghello, Romeu Sergio

; Ritt, Luiz Eduardo Fonteles

; Malafaia, Felipe Lopes

; Marinucci, Leonardo Filipe Benedeti

; Pena, José Luiz Barros

; Almeida, Antônio Eduardo Monteiro de

; Vieira, Marcelo Luiz Campos

; Stier Júnior, Arnaldo Laffitte

Arquivos Brasileiros de Cardiologia

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2024, Volume 121 N. 3 elocation e20240110

Abstract: Pt | Text: Pt | PDF: Pt

https://doi.org/10.36660/abc.20240110

EPAGRI hybrid apple cultivars resistant to Glomerella leaf spot have the Rgls resistance gene
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Ogoshi, Cláudio

; Argenta, Luiz Carlos

; Monteiro, Fernando Pereira

; Pinto, Felipe Augusto Moretti Ferreira

; Araújo, Leonardo

Revista Brasileira de Fruticultura

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2024, Volume 46 elocation e-180

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo A Mancha Foliar de Glomerella (MFG) é a principal doença dos cultivares Gala no Brasil. Estudos recentes sugerem que a resistência das macieiras à MFG é controlada por um gene recessivo chamado Rgls. Este estudo investigou se os novos cultivares de macieira da EPAGRI possuem este gene de resistência. Os cultivares avaliados foram: Fuji Suprema e Gala Real, que são padrões de resistência e suscetibilidade à MFG, respectivamente, e os novos cultivares de maçã selecionadas pela resistência fenotípica à MFG: Monalisa, Luiza, Venice, Isadora (híbridos) e Gala Gui(mutante espontâneo de Gala). O DNA dos cultivares foi extraído e amplificado, usando o marcador molecular SSR S0506206. A RT-PCR foi realizada, e os produtos, avaliados poreletroforese em gel de agarose a 2%. Os novos cultivares híbridos de maçã exibiram fragmentos de DNA amplificados, semelhantes aos da 'Fuji Suprema', indicando a presença dogene Rgls.No entanto, a 'Gala Gui' mostrou fragmentos de DNA amplificados de forma semelhante ao cultivar suscetível Gala Real. Os resultados sugerem que a resistência genética das macieiras à MFG pode ser regulada por genes diferentes do Rgls, especialmente para mutantes espontâneos de 'Gala' que são fenotipicamente resistentes à MFG. (MFG Brasil Rgls foram Real respectivamente Monalisa Luiza Venice (híbridos Guimutante Gui mutante Gala. . Gala) amplificado S0506206 S RTPCR RT PCR realizada produtos 2 2% Suprema, , Suprema' RglsNo No entanto S050620 S05062 S0506 S050 S05 S0

Abstract Glomerella Leaf Spot (GLS) is the main disease of the ‘Gala’ apple cultivar in Brazil. Recent studies have suggested that the resistance of apple trees to GLS is controlled by a recessive gene called Rgls. This study investigated whether EPAGRI new apple cultivars have this resistance gene. The cultivars evaluated were ‘Fuji Suprema’ and ‘Gala Real’, which are standards of resistance and susceptibility to GLS, respectively, and the new apple cultivars selected by the phenotypic resistance to GLS: ‘Monalisa’, ‘Luiza’, ‘Venice’, ‘Isadora’ (hybrids) and ‘Gala Gui’ (spontaneous 'Gala' mutant). The DNA of cultivars was extracted and amplified using the SSR S0506206 molecular marker. RT-PCR was performed, and its products were evaluated by electrophoresis in 2% agarose gel. The new hybrid apple cultivars exhibited amplified DNA fragments similar to those of ‘Fuji Suprema’, indicating the presence of the Rgls gene. However, ‘Gala Gui’ cultivar showed amplified DNA fragments similarly to the ‘Gala Real’ susceptible cultivar. The results suggest that the genetic resistance of apple trees to GLS may be regulated by genes other than Rgls, particularly for spontaneous 'Gala' mutants that are phenotypically resistant to GLS. (GLS Gala Brazil Fuji Suprema Real, Real , respectively ‘Monalisa, Monalisa ‘Monalisa ‘Monalisa’ ‘Luiza, Luiza ‘Luiza ‘Luiza’ ‘Venice, Venice ‘Venice ‘Venice’ ‘Isadora Isadora hybrids (hybrids Gui 'Gala mutant. mutant . mutant) S S050620 marker RTPCR RT PCR performed 2 gel Suprema, However S05062 S0506 S050 S05 S0

https://doi.org/10.1590/0100-29452024180

The woman's hand womans woman s
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Neder Filho, Antonio Tufi

; Costa, Antonio Carlos da

; Barros, Rui Sérgio Monteiro de

; Nakachima, Luís Renato

; Souza, Sandro Castro Adeodato de

; Rodrigues, Maurício Pinto

; Oliveira, Ricardo Kaempf de

; Gama, Sérgio Augusto Machado da

Revista da Associação Médica Brasileira

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2023, Volume 69 Suppl. 1 elocation e2023S108

Abstract: En | Text: En | PDF: En

https://doi.org/10.1590/1806-9282.2023s108

Hearing habits of young adolescent students from public and private schools in the Brazilian Federal District
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Silva, Valéria Gomes da

; Oliveira, Carlos Augusto Costa Pires de

; Sampaio, André Luiz Lopes

; Silva, Isabella Monteiro de Castro

; Corrêa, Camila de Castro

; Paula, Karen Maria de

Revista CEFAC

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2023, Volume 25 N. 4 elocation e2423

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Objetivo: analisar os hábitos auditivos de um grupo de alunos e comparar o grau de exposição ao estímulo sonoro via fones de ouvido entre escolas públicas e privadas. Métodos: foram distribuídos questionários contendo perguntas referentes a hábitos auditivos de exposição à música amplificada, aos 1085 alunos de escolas pública e privada. Em seguida, as respostas aos questionamentos foram analisadas e comparadas entre os grupos de alunos. Utilizou-se o teste Qui-quadrado com um nível de significância estatística estabelecido em 5% (p<0,05) para se comparar os hábitos auditivos entre as escolas públicas e privadas. Resultado: de modo geral, a maioria dos alunos (92%) respondeu que tem hábitos auditivos de exposição à música amplificada. Tanto o uso de fones de ouvido (92%) quanto as idas a lugares com música alta (63,6%) tiveram alta prevalência nas respostas aos questionários. Conclusão: alunos de escolas particulares utilizam mais fones de ouvido frequentemente comparados aos alunos de escolas públicas. Objetivo privadas Métodos amplificada 108 privada seguida Utilizouse Utilizou Quiquadrado Qui quadrado 5 p<0,05 p005 p 0 05 (p<0,05 Resultado geral 92% 92 (92% 63,6% 636 63 6 (63,6% Conclusão 10 p<0,0 p00 (p<0,0 9 (92 63,6 (63,6 1 p<0, p0 (p<0, (9 63, (63, p<0 (p<0 ( (63 p< (p< (6 (p

ABSTRACT Purpose: to analyze the hearing habits of a group of students between public and private schools and compare the degree of exposure to sound stimuli via earphones. Methods: 1,085 public and private school students received a questionnaire on hearing habits and exposure to amplified music. Their answers to these questions were analyzed and compared between the groups of students. The chi-square test compared hearing habits between public and private schools, with the statistical significance level set at 5% (p < 0.05). Result: in general, most students (92%) reported hearing habits of exposure to amplified music. Questionnaire answers indicated a high prevalence of both earphone use (92%) and attendance at places with loud music (63.6%). Conclusion: private school students use earphones more often than those from public schools. Purpose Methods 1085 1 085 1,08 chisquare chi square 5 p 0.05. 005 0.05 . 0 05 0.05) Result general 92% 92 (92% 63.6%. 636 63.6% 63 6 (63.6%) Conclusion 108 08 1,0 00 0.0 9 (92 63.6 (63.6% 10 1, 0. (9 63. (63.6 ( (63. (63 (6

https://doi.org/10.1590/1982-0216/20232542423

Diretriz da SBC sobre Diagnóstico e Tratamento de Pacientes com Cardiomiopatia da Doença de Chagas – 2023 202 20 2
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Marin-Neto, José Antonio

; Rassi Jr, Anis

; Oliveira, Gláucia Maria Moraes

; Correia, Luís Claudio Lemos

; Ramos Júnior, Alberto Novaes

; Luquetti, Alejandro Ostermayer

; Hasslocher-Moreno, Alejandro Marcel

; Sousa, Andréa Silvestre de

; Paola, Angelo Amato Vincenzo de

; Sousa, Antônio Carlos Sobral

; Ribeiro, Antonio Luiz Pinho

; Correia Filho, Dalmo

; Souza, Dilma do Socorro Moraes de

; Cunha-Neto, Edecio

; Ramires, Felix Jose Alvarez

; Bacal, Fernando

; Nunes, Maria do Carmo Pereira

; Martinelli Filho, Martino

; Scanavacca, Maurício Ibrahim

; Saraiva, Roberto Magalhães

; Oliveira Júnior, Wilson Alves de

; Lorga-Filho, Adalberto Menezes

; Guimarães, Adriana de Jesus Benevides de Almeida

; Braga, Adriana Lopes Latado

; Oliveira, Adriana Sarmento de

; Sarabanda, Alvaro Valentim Lima

; Pinto, Ana Yecê das Neves

; Carmo, Andre Assis Lopes do

; Schmidt, Andre

; Costa, Andréa Rodrigues da

; Ianni, Barbara Maria

; Markman Filho, Brivaldo

; Rochitte, Carlos Eduardo

; Macêdo, Carolina Thé

; Mady, Charles

; Chevillard, Christophe

; Virgens, Cláudio Marcelo Bittencourt das

; Castro, Cleudson Nery de

; Britto, Constança Felicia De Paoli de Carvalho

; Pisani, Cristiano

; Rassi, Daniela do Carmo

; Sobral Filho, Dário Celestino

; Almeida, Dirceu Rodrigues de

; Bocchi, Edimar Alcides

; Mesquita, Evandro Tinoco

; Mendes, Fernanda de Souza Nogueira Sardinha

; Gondim, Francisca Tatiana Pereira

; Silva, Gilberto Marcelo Sperandio da

; Peixoto, Giselle de Lima

; Lima, Gustavo Glotz de

; Veloso, Henrique Horta

; Moreira, Henrique Turin

; Lopes, Hugo Bellotti

; Pinto, Ibraim Masciarelli Francisco

; Ferreira, João Marcos Bemfica Barbosa

; Nunes, João Paulo Silva

; Barreto-Filho, José Augusto Soares

; Saraiva, José Francisco Kerr

; Lannes-Vieira, Joseli

; Oliveira, Joselina Luzia Menezes

; Armaganijan, Luciana Vidal

; Martins, Luiz Cláudio

; Sangenis, Luiz Henrique Conde

; Barbosa, Marco Paulo Tomaz

; Almeida-Santos, Marcos Antonio

; Simões, Marcos Vinicius

; Yasuda, Maria Aparecida Shikanai

; Moreira, Maria da Consolação Vieira

; Higuchi, Maria de Lourdes

; Monteiro, Maria Rita de Cassia Costa

; Mediano, Mauro Felippe Felix

; Lima, Mayara Maia

; Oliveira, Maykon Tavares de

; Romano, Minna Moreira Dias

; Araujo, Nadjar Nitz Silva Lociks de

; Medeiros, Paulo de Tarso Jorge

; Alves, Renato Vieira

; Teixeira, Ricardo Alkmim

; Pedrosa, Roberto Coury

; Aras Junior, Roque

; Torres, Rosalia Morais

; Povoa, Rui Manoel dos Santos

; Rassi, Sergio Gabriel

; Alves, Silvia Marinho Martins

; Tavares, Suelene Brito do Nascimento

; Palmeira, Swamy Lima

; Silva Júnior, Telêmaco Luiz da

; Rodrigues, Thiago da Rocha

; Madrini Junior, Vagner

; Brant, Veruska Maia da Costa

; Dutra, Walderez Ornelas

; Dias, João Carlos Pinto

Arquivos Brasileiros de Cardiologia

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2023, Volume 120 N. 6 elocation e20230269

Abstract: Pt | Text: Pt | PDF: Pt

https://doi.org/10.36660/abc.20230269

Consumption of ultra-processed foods in Brazil: distribution and temporal evolution 2008–2018 ultraprocessed ultra processed Brazil 20082018 2008 2018 2008–201 2008201 200 201 2008–20 200820 20 2008–2 20082 2 2008–
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Louzada, Maria Laura da Costa

; Cruz, Gabriela Lopes da

; Silva, Karina Augusta Aparecida Nogueira

; Grassi, Ana Giulia Forjaz

; Andrade, Giovanna Calixto

; Rauber, Fernanda

; Levy, Renata Bertazzi

; Monteiro, Carlos Augusto

Revista de Saúde Pública

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2023, Volume 57 elocation 12

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO OBJETIVO Avaliar fatores sociodemográficos associados ao consumo de alimentos ultraprocessados e a evolução temporal do consumo no Brasil entre 2008 e 2018. MÉTODOS Foram utilizados dados do consumo alimentar de indivíduos com idade ≥ 10 anos das Pesquisas de Orçamentos Familiares (POF) 2008–2009 e 2017–2018. Os alimentos foram agrupados segundo a classificação Nova. Modelos de regressão linear brutos e ajustados foram utilizados para avaliar a associação entre características sociodemográficas e o consumo de ultraprocessados em 2017–2018 e a variação temporal de seu consumo entre 2008 e 2018. RESULTADOS Alimentos ultraprocessados representaram 19,7% das calorias em 2017–2018. A análise ajustada mostrou que seu consumo foi maior no sexo feminino ( versus masculino) e nas regiões Sul e Sudeste ( versus Norte), e menor em negros ( versus brancos) e na área rural ( versus urbana), além de diminuir com o aumento da idade e aumentar com escolaridade e renda. O consumo de ultraprocessados aumentou 1,02 pontos percentuais (pp) de 2008–2009 a 2017–2018, sendo este aumento mais expressivo em homens (+1,59 pp), negros (+2,04 pp), indígenas (+5,96 pp), na área rural (+2,43 pp), naqueles com até 4 anos de estudo (+1,18 pp), no quinto mais baixo de renda (+3,54 pp) e nas regiões Norte (+2,95 pp) e Nordeste (+3,11 pp). Por outro lado, seu consumo se reduziu na maior faixa de escolaridade (-3,30 pp) e no quinto mais alto de renda (-1,65 pp). CONCLUSÕES Os segmentos socioeconômicos e demográficos que tiveram menor consumo relativo de ultraprocessados em 2017–2018 são justamente os que apresentaram um aumento mais expressivo na análise temporal, apontando para uma tendência de padronização nacional em um patamar de consumo mais alto. 200 2018 1 POF (POF 20082009 2009 2008–200 20172018 2017 Nova 2017–201 197 19 7 19,7 masculino Norte, , Norte) brancos urbana, urbana urbana) 102 02 1,0 pp (pp +1,59 159 59 (+1,5 pp, +2,04 204 2 04 (+2,0 +5,96 596 5 96 (+5,9 +2,43 243 43 (+2,4 +1,18 118 18 (+1,1 +3,54 354 3 54 (+3,5 +2,95 295 95 (+2,9 +3,11 311 11 (+3,1 pp. . lado 3,30 330 30 (-3,3 1,65 165 65 (-1,6 20 201 2008200 2008–20 2017201 2017–20 19, 0 1, +1,5 15 (+1, +2,0 (+2, +5,9 9 (+5, +2,4 24 +1,1 +3,5 35 (+3, +2,9 29 +3,1 31 3,3 33 (-3, 1,6 16 6 (-1, 200820 2008–2 201720 2017–2 +1, (+1 +2, (+2 +5, (+5 +3, (+3 3, (-3 (-1 20082 2008– 20172 2017– +1 (+ +2 +5 +3 (- +

ABSTRACT OBJECTIVE To evaluate sociodemographic factors associated with the consumption of ultra-processed foods and the temporal evolution of their consumption in Brazil between 2008 and 2018. METHODS The study used food consumption data of individuals aged ≥ 10 years from 2008–2009 and 2017–2018 Pesquisas de Orçamentos Familiares (POF - Household Budget Surveys), grouping the foods according to the Nova classification. We used crude and adjusted linear regression models to assess the association between sociodemographic characteristics and consumption of ultra-processed foods in 2017–2018 and the temporal variation in their consumption between 2008 and 2018. RESULTS Ultra-processed foods accounted for 19.7% of calories in 2017–2018. The adjusted analysis showed that their consumption was higher in women (versus men) and the South and Southeast regions (versus North) and lower in blacks (versus whites) and rural areas (versus urban), in addition to decreasing with the increased age and increasing with higher education and income. Consumption of ultra-processed foods increased by 1.02 percentage points (pp) from 2008–2009 to 2017–2018. This increase was significantly higher among men (+1.59 pp), black people (+2.04 pp), indigenous (+5.96 pp), in the rural area (+2.43 pp), those with up to 4 years of schooling (+1.18 pp), in the lowest income quintile (+3.54 pp), and the North (+2.95 pp) and Northeast (+3.11 pp) regions. On the other hand, individuals in the highest level of schooling (-3.30 pp) and the highest income quintile (-1.65 pp) reduced their consumption. CONCLUSIONS The socioeconomic and demographic segments with the lowest relative consumption of ultra-processed foods in 2017–2018 are precisely those that showed the most significant increase in the temporal analysis, pointing to a trend towards national standardization at a higher level of consumption. ultraprocessed ultra processed 200 2018 1 20082009 2009 2008–200 20172018 2017 2017–201 POF Surveys, Surveys , Surveys) classification Ultraprocessed Ultra 197 19 7 19.7 versus whites urban, urban urban) 102 02 1.0 pp (pp +1.59 159 59 (+1.5 pp, +2.04 204 2 04 (+2.0 +5.96 596 5 96 (+5.9 +2.43 243 43 (+2.4 +1.18 118 18 (+1.1 +3.54 354 3 54 (+3.5 +2.95 295 95 (+2.9 +3.11 311 11 (+3.1 hand 3.30 330 30 (-3.3 1.65 165 65 (-1.6 20 201 2008200 2008–20 2017201 2017–20 19. 0 1. +1.5 15 (+1. +2.0 (+2. +5.9 9 (+5. +2.4 24 +1.1 +3.5 35 (+3. +2.9 29 +3.1 31 3.3 33 (-3. 1.6 16 6 (-1. 200820 2008–2 201720 2017–2 +1. (+1 +2. (+2 +5. (+5 +3. (+3 3. (-3 (-1 20082 2008– 20172 2017– +1 (+ +2 +5 +3 (- + (

https://doi.org/10.11606/s1518-8787.2023057004744

Consumption of ultra-processed foods in Brazil: distribution and temporal evolution 2008–2018
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Louzada, Maria Laura da Costa

; Cruz, Gabriela Lopes da

; Silva, Karina Augusta Aparecida Nogueira

; Grassi, Ana Giulia Forjaz

; Andrade, Giovanna Calixto

; Rauber, Fernanda

; Levy, Renata Bertazzi

; Monteiro, Carlos Augusto

Revista de Saúde Pública

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2023, Volume 57 elocation 12

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.11606/s1518-8787.2023057004744

10.

[SciELO Preprints] - Guideline of the Brazilian Society of Cardiology on Diagnosis and Treatment of Patients with Chagas Disease Cardiomyopathy
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Marin-Neto, José Antonio Rassi Jr., Anis Moraes Oliveira, Gláucia M. Lemos Correia, Luís Claudio Novaes Ramos Jr., Alberto Hasslocher-Moreno, Alejandro Marcel Luquetti Ostermayer, Alejandro Sousa, Andréa Silvestre de Amato Vincenzo de Paola, Angelo Sobral de Sousa, Antonio Carlos Pinho Ribeiro, Antonio Luiz Correia Filho, Dalmo Moraes de Souza, Dilma do Socorro Cunha-Neto, Edecio J. A. Ramires, Felix Bacal, Fernando Pereira Nunes, Maria do Carmo Martinelli Filho, Martino Ibrahim Scanavacca, Maurício Magalhães Saraiva, Roberto Alves de Oliveira Júnior, Wilson M. Lorga-Filho, Adalberto de Jesus Benevides de Almeida Guimarães, Adriana Lopes Latado Braga, Adriana Sarmento de Oliveira, Adriana V. L. Sarabanda, Alvaro Yecê das Neves Pinto, Ana Assis Lopes do Carmo, André Schmidt, André Costa, Andréa Rodrigues da Ianni, Barbara Maria Markman Filho, Brivaldo Eduardo Rochitte, Carlos Thé Macedo, Carolina Mady, Charles Chevillard, Christophe Bittencourt das Virgens, Cláudio Marcelo Nery de Castro, Cleudson De Paoli de Carvalho Britto, Constança Felícia Pisani, Cristiano do Carmo Rassi, Daniela C. Sobral Filho, Dario Rodrigues Almeida, Dirceu A. Bocchi, Edimar T. Mesquita, Evandro de Souza Nogueira Sardinha Mendes, Fernanda Pereira, Francisca Tatiana Sperandio da Silva, Gilberto Marcelo de Lima Peixoto, Giselle Glotz de Lima, Gustavo H. Veloso, Henrique Turin Moreira, Henrique Bellotti Lopes, Hugo Masciarelli Francisco Pinto, Ibraim Pinto Dias, João Carlos Bemfica, João Marcos Silva-Nunes, João Paulo Soares Barreto-Filho, José Augusto Kerr Saraiva, José Francisco Lannes-Vieira, Joseli Menezes Oliveira, Joselina Luzia V. Armaganijan, Luciana Martins, Luiz Cláudio C. Sangenis, Luiz Henrique Barbosa, Marco Paulo Almeida-Santos, Marcos Antônio Simões, Marcos Vinicius Shikanai-Yasuda, Maria Aparecida Vieira Moreira, Maria da Consolação Higuchi, Maria de Lourdes Costa Monteiro, Maria Rita de Cássia Felix Mediano, Mauro Felippe Maia Lima, Mayara T. Oliveira, Maykon Moreira Dias Romano , Minna Nitz, Nadjar de Tarso Jorge Medeiros, Paulo Vieira Alves, Renato Alkmim Teixeira, Ricardo Coury Pedrosa, Roberto Aras, Roque Morais Torres, Rosália dos Santos Povoa, Rui Manoel Rassi, Sérgio Gabriel Salles Xavier, Sérgio Marinho Martins Alves , Silvia B. N. Tavares, Suelene Lima Palmeira, Swamy da Silva Junior, Telêmaco Luiz da Rocha Rodrigues, Thiago Madrini Junior, Vagner Maia da Costa , Veruska Dutra, Walderez

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Publication date: 2022-10-11

Abstract: En Pt

This guideline aimed to update the concepts and formulate the standards of conduct and scientific evidence that support them, regarding the diagnosis and treatment of the Cardiomyopathy of Chagas disease, with special emphasis on the rationality base that supported it.nbsp; Chagas disease in the 21st century maintains an epidemiological pattern of endemicity in 21 Latin American countries. Researchers and managers from endemic and non-endemic countries point to the need to adopt comprehensive public health policies to effectively control the interhuman transmission of T. cruzi infection, and to obtain an optimized level of care for already infected individuals, focusing on diagnostic and therapeutic opportunistic opportunities. nbsp; Pathogenic and pathophysiological mechanisms of the Cardiomyopathy of Chagas disease were revisited after in-depth updating and the notion that necrosis and fibrosis are stimulated by tissue parasitic persistence and adverse immune reaction, as fundamental mechanisms, assisted by autonomic and microvascular disorders, was well established. Some of them have recently formed potential targets of therapies.nbsp; The natural history of the acute and chronic phases was reviewed, with enhancement for oral transmission, indeterminate form and chronic syndromes. Recent meta-analyses of observational studies have estimated the risk of evolution from acute and indeterminate forms and mortality after chronic cardiomyopathy. Therapeutic approaches applicable to individuals with Indeterminate form of Chagas disease were specifically addressed. All methods to detect structural and/or functional alterations with various cardiac imaging techniques were also reviewed, with recommendations for use in various clinical scenarios. Mortality risk stratification based on the Rassi score, with recent studies of its application, was complemented by methods that detect myocardial fibrosis.nbsp; The current methodology for etiological diagnosis and the consequent implications of trypanonomic treatment deserved a comprehensive and in-depth approach. Also the treatment of patients at risk or with heart failure, arrhythmias and thromboembolic events, based on pharmacological and complementary resources, received special attention. Additional chapters supported the conducts applicable to several special contexts, including t. cruzi/HIV co-infection, risk during surgeries, in pregnant women, in the reactivation of infection after heart transplantation, and others.nbsp; nbsp;nbsp; Finally, two chapters of great social significance, addressing the structuring of specialized services to care for individuals with the Cardiomyopathy of Chagas disease, and reviewing the concepts of severe heart disease and its medical-labor implications completed this guideline.

Esta diretriz teve como objetivo principal atualizar os conceitos e formular as normas de conduta e evidências científicas que as suportam, quanto ao diagnóstico e tratamento da CDC, com especial ênfase na base de racionalidade que a embasou. A DC no século XXI mantém padrão epidemiológico de endemicidade em 21 países da América Latina. Investigadores e gestores de países endêmicos e não endêmicos indigitam a necessidade de se adotarem políticas abrangentes, de saúde pública, para controle eficaz da transmissão inter-humanos da infecção pelo T. cruzi, e obter-se nível otimizado de atendimento aos indivíduos já infectados, com foco em oportunização diagnóstica e terapêutica. Mecanismos patogênicos e fisiopatológicos da CDC foram revisitados após atualização aprofundada e ficou bem consolidada a noção de que necrose e fibrose sejam estimuladas pela persistência parasitária tissular e reação imune adversa, como mecanismos fundamentais, coadjuvados por distúrbios autonômicos e microvasculares. Alguns deles recentemente constituíram alvos potenciais de terapêuticas. A história natural das fases aguda e crônica foi revista, com realce para a transmissão oral, a forma indeterminada e as síndromes crônicas. Metanálises recentes de estudos observacionais estimaram o risco de evolução a partir das formas aguda e indeterminada e de mortalidade após instalação da cardiomiopatia crônica. Condutas terapêuticas aplicáveis aos indivíduos com a FIDC foram abordadas especificamente. Todos os métodos para detectar alterações estruturais e/ou funcionais com variadas técnicas de imageamento cardíaco também foram revisados, com recomendações de uso nos vários cenários clínicos. Estratificação de risco de mortalidade fundamentada no escore de Rassi, com estudos recentes de sua aplicação, foi complementada por métodos que detectam fibrose miocárdica. A metodologia atual para diagnóstico etiológico e as consequentes implicações do tratamento tripanossomicida mereceram enfoque abrangente e aprofundado. Também o tratamento de pacientes em risco ou com insuficiência cardíaca, arritmias e eventos tromboembólicos, baseado em recursos farmacológicos e complementares, recebeu especial atenção. Capítulos suplementares subsidiaram as condutas aplicáveis a diversos contextos especiais, entre eles o da co-infecção por T. cruzi/HIV, risco durante cirurgias, em grávidas, na reativação da infecção após transplante cardíacos, e outros.nbsp;nbsp;nbsp; Por fim, dois capítulos de grande significado social, abordando a estruturação de serviços especializados para atendimento aos indivíduos com a CDC, e revisando os conceitos de cardiopatia grave e suas implicações médico-trabalhistas completaram esta diretriz.nbsp;

https://doi.org/10.1590/SciELOPreprints.4820

11.

Choir Singing Practice and Temporal Ordering in the Elderly
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Zukowski, Debora Bonizio

; Junker, David Bretanha

; da Silva, Isabella Monteiro Castro

; Viana, Lucas Moura

; de Oliveira, Carlos Augusto Pires

International Archives of Otorhinolaryngology

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jun 2022, Volume 26 N. 2 Pages e199 - e207

Abstract: En | Text: En | PDF: En

Abstract Introduction The importance of temporal ordering and sequencing in the auditory system is discussed because these are considered basic functions for language. Objective To verify the correlation between the practice of choir music and the temporal ordering in elderly with no prior formal musical experience. Method The study design is cross-sectional. The sample consisted of 85 elderly individuals of both genders, ≥ 60 years old, and it was composed of 43 elderly individuals with no prior formal musical experience but choir participation (research group) and 42 elderly individuals who never sang in a choir and had no music training during their life (control group). The research group was divided based on three categories of choir time. The performances of the research and control groups were compared with pitch pattern sequence (PPS), verbal condition (PPSverb), humming condition (PPShum), and duration pattern sequence (DPS) tests. Results The mean PPShum and PPSverb showed a statistically significant difference by choir time with a different mean of PPShum between the no singing experience group (59%) and the > 10 years of singing experience group (90%) (p= 0.02). Regarding the averages of PPSverb, there was a statistically significant difference between the no singing experience (23%) and > 10 years of choir time (54%) (p= 0.02) groups. Conclusion The findings indicate a better performance in the temporal ordering of the elderly who are not formal musicians but who have choir experience in the research group in relation to those with no choir experience in the control group.

https://doi.org/10.1055/s-0041-1733930

12.

Score of ultra-processed food consumption and its association with sociodemographic factors in the Brazilian National Health Survey, 2019
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Costa, Caroline dos Santos

; Steele, Eurídice Martínez

; Faria, Franciane Rocha de

; Monteiro, Carlos Augusto

Cadernos de Saúde Pública

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2022, Volume 38 Suppl. 1 elocation e00119421

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

Estudo transversal de base populacional com objetivo de descrever o escore de consumo de alimentos ultraprocessados, avaliado na Pesquisa Nacional de Saúde em 2019, e sua associação com fatores sociodemográficos em adultos brasileiros (com 18 anos ou mais). O escore de consumo de alimentos ultraprocessados foi calculado, somando as respostas positivas a perguntas sobre o consumo no dia anterior de dez subgrupos de alimentos ultraprocessados, consumidos frequentemente no Brasil. A distribuição da pontuação na população foi apresentada na forma de contagem. Foram utilizados modelos de regressão de Poisson para avaliar as associações brutas e ajustadas para pontuações iguais ou maiores de subgrupos de ultraprocessados, de acordo com situação (urbana/rural), macrorregião, sexo, grupo etário, escolaridade e índice de riqueza. Cerca de 15% dos adultos brasileiros obtiveram pontuações iguais ou superiores a cinco. Após ajustar para fatores de confusão, a prevalência do consumo de cinco ou mais subgrupos de ultraprocessados diminuiu de maneira linear com a idade, aumentou de maneira linear com os quintis de renda e foi mais alta nas áreas urbanas, nas regiões Sul e Sudeste e em homens. São necessárias políticas públicas que reduzam o consumo de alimentos ultraprocessados, com ênfase nos segmentos da população com maior risco. Para avaliar o sucesso dessas políticas, será importante monitorar os níveis de consumo de ultraprocessados entre os diversos estudos e populações.

This is a cross-sectional population-based study that describes the score of ultra-processed food consumption, applied in the Brazilian National Health Survey performed in 2019, and its association with sociodemographic factors in Brazilian adults (18 years or older). The score of ultra-processed food consumption was calculated by adding up the positive answers about the consumption on the previous day of 10 subgroups of ultra-processed foods frequently consumed in Brazil. The distribution of the score in the population was presented as a count. Poisson regression models were used to evaluate the crude and adjusted associations of scores equal to or higher than five subgroups of ultra-processed foods with urban/rural area, geographic region, sex, age group, schooling level, and wealth index. About 15% of the Brazilian adults reached scores equal to or higher than five. After adjustment for confounders, the prevalence of consuming five or more subgroups of ultra-processed foods decreased linearly with age, increased linearly with wealth quintiles and it was higher in urban areas, in the Southeast and South regions (compared to the others) and in men. Public policies that reduce the consumption of ultra-processed foods with emphasis on strata of the population at the greatest risk are essential and monitoring the score of ultra-processed food consumption across studies and populations will be important to assess the success of these policies.

El objetivo de este estudio transversal, de base poblacional, es describir la puntuación para el consumo de comida ultraprocesada y su asociación con factores sociodemográficos en adultos brasileños (con 18 años de edad o más). Los datos proceden de la Encuesta Nacional de Salud llevada a cabo en 2019. La puntuación para el consumo de comida ultraprocesada se calculó sumando las respuestas positivas a preguntas sobre el consumo el día previo de 10 subgrupos de comidas ultraprocesadas frecuentemente consumidas en Brasil. La distribución de la puntuación en la población se presentó como un dato de conteo. Fueron utilizados modelos de regressioón de Poison para evaluar las asociaciones crudas y ajustadas de puntuaciones iguales a o superiores a cinco subgrupos de comidas ultraprocesadas con áreas urbanas/rurales, región geográfica, sexo, grupo de edad, nivel de escolaridad, e índice de riqueza. Alrededor de un 15% de los adultos brasileños alcanzaron puntuaciones iguales o mayores que cinco. Tras el ajuste para los factores de confusión, la prevalencia del consumo de cinco o más subgrupos de comidas ultraprocesadas decrecío, aumentando linealmente con los quintiles de riqueza y era superior en las áreas urbanas, en las regiones Sur y Sudeste (comparadas con las otras) y en hombres. Son necesarias políticas públicas para reducir el consumo de comidas ultraprocesadas con enfásis en los estratos poblacionales en mayor riesgo. Monitorear la puntuación del consumo de comida ultraprocesada a través de estudios y poblaciones será importante para evaluar el éxito de estas políticas.

https://doi.org/10.1590/0102-311x00119421

13.

Score of ultra-processed food consumption and its association with sociodemographic factors in the Brazilian National Health Survey, 2019
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Costa, Caroline dos Santos

; Steele, Eurídice Martínez

; Faria, Franciane Rocha de

; Monteiro, Carlos Augusto

Cadernos de Saúde Pública

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2022, Volume 38 Suppl. 1 elocation e00119421

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

https://doi.org/10.1590/0102-311x00119421

14.

Ultra-processed food intake and diet carbon and water footprints: a national study in Brazil
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Garzillo, Josefa Maria Fellegger

; Poli, Vanessa Fadanelli Schoenardie

; Leite, Fernanda Helena Marrocos

; Steele, Euridice Martinez

; Machado, Priscila Pereira

; Louzada, Maria Laura da Costa

; Levy, Renata Bertazzi

; Monteiro, Carlos Augusto

Revista de Saúde Pública

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2022, Volume 56 elocation 6

Abstract: En | Text: En | PDF: En

ABSTRACT OBJECTIVE To study the association between ultra-processed food consumption and carbon and water footprints of the Brazilian diet. METHODS Cross-sectional analysis on data collected in 2008–2009 on a probabilistic sample of the Brazilian population aged ≥ 10 years (n = 32,886). Individual food intake was assessed using two 24-hour food records, on non-consecutive days. The environmental impact of individual diets was calculated by multiplying the amount of each food by coefficients that quantify the atmospheric emissions of greenhouse gases in grams of carbon dioxide equivalent (carbon footprint) and freshwater use in liters (water footprint), both per gram or milliliter of food. The two coefficients consider the food life cycle ‘from farm to fork.’ Crude and adjusted linear regression models and tests for linear trends assessed the association between the ultra-processed food contribution to total energy intake (quintiles) and the diet carbon and water footprints. Potential confounders included age, sex, education, income, and region. Total energy intake was assessed as a potential mediation variable. RESULTS In the crude models, the dietary contribution of ultra-processed foods was linearly associated with the carbon and water footprints of the Brazilian diet. After adjustment for potential confounders, the association remained significant only regarding the diet water footprint, which increased by 10.1% between the lowest and highest quintile of the contribution of ultra-processed foods. Additional adjustment for total energy intake eliminated this association indicating that the dietary contribution of ultra-processed foods increases the diet water footprint by increasing energy intake. CONCLUSIONS The negative impact of ultra-processed foods on the diet water footprint, shown for the first time in this study, adds to the negative impacts of these foods, already demonstrated regarding dietary nutrient profiles and the risk for several chronic non-communicable diseases. This reinforces the recommendation to avoid ultra-processed foods made in the official Brazilian Dietary Guidelines and increasingly in dietary guidelines of other countries.

https://doi.org/10.11606/s1518-8787.2022056004551

15.

Ultra-processed food intake and diet carbon and water footprints: a national study in Brazil
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Garzillo, Josefa Maria Fellegger

; Poli, Vanessa Fadanelli Schoenardie

; Leite, Fernanda Helena Marrocos

; Steele, Euridice Martinez

; Machado, Priscila Pereira

; Louzada, Maria Laura da Costa

; Levy, Renata Bertazzi

; Monteiro, Carlos Augusto

Revista de Saúde Pública

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2022, Volume 56 elocation 6

Abstract: En | Text: En | PDF: En

https://doi.org/10.11606/s1518-8787.2022056004551

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