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1.
Ações de assistência à saúde ofertadas à população em situação de rua: estado da arte rua
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Resumo A população em situação de rua (PSR) vem aumentando nos últimos anos. Ações governamentais são implementadas para melhorar as condições de vida dessa população, especialmente as voltadas à assistência à saúde. Este estudo tem como questão norteadora: quais são as estratégias de atenção à saúde dos serviços e programas voltados à população em situação de rua no Brasil? O objetivo é analisar quais são as estratégias de atenção à saúde adotadas pelos serviços e programas voltados à população em situação de rua no Brasil. Foi realizada uma revisão sistemática da literatura nas bases de dados Biblioteca Virtual em Saúde (BVS), Literatura Latino Americana e do Caribe em Ciências da Saúde (Lilacs) e Scientific Eletronic Library Online (SciELO), tendo como resultado 21 artigos. A análise revelou os alcances e desafios das redes de atenção à saúde, indicando o uso de drogas como principal motivo para busca dos serviços, sendo o Consultório na Rua (CnaR) um dispositivo importante, capaz de promover a criação de vínculos entre a PSR e os demais setores de saúde. A importância do trabalho em rede e a complexidade do cuidado com a saúde de populações foram temas recorrentes nas discussões, pois tratam de ações destinadas a pessoas vulnerabilizadas, estigmatizadas, apresentando necessidades e singularidades no modo de viver em sociedade. (PSR anos norteadora Brasil BVS, BVS , (BVS) Lilacs (Lilacs SciELO, SciELO (SciELO) 2 artigos CnaR (CnaR importante discussões vulnerabilizadas estigmatizadas sociedade (BVS (SciELO
Abstract The number of homeless people (HP) has been increasing in recent years. Government actions have been implemented to improve the living conditions for this population, especially those focused on health care. This study has as research question: What are the healthcare strategies of services and programs being offered to the homeless population in Brazil? Its objective is to analyze the health care strategies adopted by services and programs offered to the homeless population in Brazil. To achieve this purpose, a search was conducted in the Virtual Health Library (VHL), Latin American and Caribbean Literature in Health Sciences (Lilacs), and Scientific Electronic Library Online (SciELO) databases, resulting in 21 articles. The analysis revealed the scope and challenges of the health care networks, indicating drug use as the main reason for seeking the services, with the Street Clinics (CnaR, Consultório na Rua) being an important service capable of promoting the creation of links between the HP and other sectors. of health. The importance of networking and the complexity of population health care were recurring topics in the discussions, as they deal with actions aimed at vulnerable and stigmatized people, showing needs and singularities in the way of living in society. (HP years question Brazil purpose VHL, VHL , (VHL) Lilacs, Lilacs (Lilacs) SciELO (SciELO databases 2 articles networks CnaR, CnaR (CnaR Rua sectors discussions society (VHL (Lilacs
2.
Ações de assistência à saúde ofertadas à população em situação de rua: estado da arte
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Resumo A população em situação de rua (PSR) vem aumentando nos últimos anos. Ações governamentais são implementadas para melhorar as condições de vida dessa população, especialmente as voltadas à assistência à saúde. Este estudo tem como questão norteadora: quais são as estratégias de atenção à saúde dos serviços e programas voltados à população em situação de rua no Brasil? O objetivo é analisar quais são as estratégias de atenção à saúde adotadas pelos serviços e programas voltados à população em situação de rua no Brasil. Foi realizada uma revisão sistemática da literatura nas bases de dados Biblioteca Virtual em Saúde (BVS), Literatura Latino Americana e do Caribe em Ciências da Saúde (Lilacs) e Scientific Eletronic Library Online (SciELO), tendo como resultado 21 artigos. A análise revelou os alcances e desafios das redes de atenção à saúde, indicando o uso de drogas como principal motivo para busca dos serviços, sendo o Consultório na Rua (CnaR) um dispositivo importante, capaz de promover a criação de vínculos entre a PSR e os demais setores de saúde. A importância do trabalho em rede e a complexidade do cuidado com a saúde de populações foram temas recorrentes nas discussões, pois tratam de ações destinadas a pessoas vulnerabilizadas, estigmatizadas, apresentando necessidades e singularidades no modo de viver em sociedade.
Abstract The number of homeless people (HP) has been increasing in recent years. Government actions have been implemented to improve the living conditions for this population, especially those focused on health care. This study has as research question: What are the healthcare strategies of services and programs being offered to the homeless population in Brazil? Its objective is to analyze the health care strategies adopted by services and programs offered to the homeless population in Brazil. To achieve this purpose, a search was conducted in the Virtual Health Library (VHL), Latin American and Caribbean Literature in Health Sciences (Lilacs), and Scientific Electronic Library Online (SciELO) databases, resulting in 21 articles. The analysis revealed the scope and challenges of the health care networks, indicating drug use as the main reason for seeking the services, with the Street Clinics (CnaR, Consultório na Rua) being an important service capable of promoting the creation of links between the HP and other sectors. of health. The importance of networking and the complexity of population health care were recurring topics in the discussions, as they deal with actions aimed at vulnerable and stigmatized people, showing needs and singularities in the way of living in society.
3.
Correlation of Apolipoprotein a-i with Renal Function in Diabetic Patients ai a i
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Pereira, Maria Liliane Luciano
; Costa, Mac Dionys Rodrigues da
; Viana, Glautemberg de Almeida
; Magalhães, Emanuel Paula
; Duque, Bruna Ribeiro
; Silva, Mateus Edson da
; Teixeira, Izabell Maria Martins
; Alves, Renata de Sousa
; Menezes, Ramon Róseo Paula Pessoa Bezerra de
; Martins, Alice Maria Costa
; Queiroz, Maria Goretti Rodrigues de
; Sampaio, Tiago Lima
.
Abstract Diabetes mellitus (DM) is a major cause of chronic kidney disease (CKD) and changes in lipoprotein. Literature data suggest that cholesterol associated with high-density lipoprotein (HDLc) plays a protective role against albuminuria and diabetic nephropathy. These factors are related with changes in serum apolipoproteins such Apo A-I. This work aims to evaluate the correlation of apolipoprotein A-I with renal function in diabetic outpatients. Samples were collected from 281 outpatients for analyses of glycated hemoglobin (HbA1c), serum creatinine (SCr), urea (BUN), cholesterol (TC), triglycerides (TG), HDL-cholesterol (HDLc) and estimation of glomerular filtration rate (eGFR). Urinary samples were obtained to assess urine albumin creatinine ratio (UACR). Triglyceride-glucose index (TyG) was calculated to estimate insulin resistance. The mean age was 61,5 ± 16,4 years. Most patients were female, Afro-Mestizo and over 50 years of age. Pearson's revealed negative correlation of creatinine with HDLc and Apo A-I. There was a correlation of eGFR with HbA1c, TG and HDLc. TyG presented a negative correlation with Apo A-I and HDLc. The highest quartiles of UACR presented the highest TyG and the lowest Apo A-I. In conclusion, Apo A-I indicated an association with insulin resistance and changes in renal function parameters, especially as a factor associated with the onset of albuminuria, with a better predictive potential than the HDLc. DM (DM CKD (CKD highdensity high density (HDLc nephropathy AI. AI A I. I 28 HbA1c HbAc , HbA c (HbA1c) SCr, SCr (SCr) BUN, BUN (BUN) TC, TC (TC) TG, (TG) HDLcholesterol HDL eGFR. . (eGFR) UACR. (UACR) Triglycerideglucose Triglyceride glucose (TyG 615 61 5 61, 164 16 4 16, female AfroMestizo Afro Mestizo Pearsons Pearson s conclusion parameters 2 (HbA1c (SCr (BUN (TC (TG (eGFR (UACR 6 1
4.
APRENDIZADO DE MÁQUINA APLICADO A QSAR
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Over the years the study of the quantitative structure-activity relationship (QSAR) has transformed from a simple regression analysis to the implementation of machine learning (ML) with multiple statistics. Today ML-based QSAR models are quite important and play a notable role in drug design and screening, property prediction, biological activity, etc. ML methods applied to QSAR build classification or regression models to describe/predict the complex relationships between the chemical structure of molecules and biological activity. Even with the increase in scientific publications addressing this topic written in Portuguese, there is still a shortage of scientific articles explaining ML techniques applied to QSAR, how to build models, the types of models, algorithms, for the Brazilian scientific community. And to fill this need, we intend to approach the subject in a simple and didactic way for students and researchers who are starting in this very promising and important area. We will describe the fully explained theory of machine learning by applying QSAR, abstracting the complexity, and well-illustrated. structureactivity activity (QSAR (ML statistics MLbased based screening prediction etc describepredict predict Portuguese algorithms community need area complexity wellillustrated. wellillustrated well illustrated. illustrated well-illustrated
5.
Consensus of the Brazilian association of hematology, hemotherapy and cellular therapy on patient blood management: Anemia tolerance mechanisms hematology management
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Rodrigues, Roseny dos Reis
; Brunetta, Denise Menezes
; Costa, Lorena
; Benites, Bruno Deltreggia
; Magnus, Mariana Munari
; Alves, Susankerle de Oliveira Costa
; Santis, Gil Cunha De
; Rizzo, Silvia Renata Cornélio Parolin
; Rabello, Guilherme
; Langhi Junior, Dante Mario
.
Abstract Understanding the physiological concepts of oxygen delivery is essential to discern the mechanisms that influence its increase, reduction or maintenance in the body. This text explores the different mechanisms that help maintain oxygen delivery even in the face of reduced hemoglobin levels. Adequate oxygen delivery ensures tissue and metabolic balance, which is crucial to avoid harmful consequences such as metabolic acidosis and cellular dysoxia. The complex interaction between variables such as cardiac output, hemoglobin and heart rate (HR) plays a fundamental role in maintaining oxygen delivery, allowing the body to temporarily adjust to situations of anemia or high metabolic demand. It is important to emphasize that blood transfusions should not be based on fixed values, but rather on individual metabolic needs. Strategies to reduce myocardial consumption and monitor macro and micro hemodynamics help in making rational decisions. Individualizing treatment and considering factors such as blood viscosity in relation to the benefits of transfusion are increasingly relevant to optimize therapy and minimize risks, especially in complex clinical scenarios, such as neurocritical patients and trauma victims. increase levels balance dysoxia output HR (HR demand values needs decisions risks scenarios victims
6.
Consensus of the Brazilian association of hematology, hemotherapy and cellular therapy on patient blood management: Assessment and management of postoperative anemia hematology
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Benites, Bruno Deltreggia
; Magnus, Mariana Munari
; Costa, Lorena
; Brunetta, Denise Menezes
; Rodriges, Roseny dos Reis
; Alves, Susankerle de Oliveira Costa
; Santis, Gil Cunha De
; Rizzo, Silvia Renata Cornélio Parolin
; Rabello, Guilherme
; Langhi Junior, Dante Mario
.
Abstract Postoperative anemia is a complex clinical issue that requires attention due to its ramifications on the patient's recovery and prognosis. Originating from multiple determinants, such as intraoperative blood loss, hemolysis, nutritional deficiencies, systemic inflammation and impact on the bone marrow, postoperative anemia has varied and often challenging presentations. Patients undergoing major surgical procedures, in particular, are susceptible to developing anemia due to the considerable associated blood loss. Accurate diagnosis plays a crucial role in the approach, requiring meticulous hematological analysis, including hemoglobin, hematocrit and reticulocyte count, as well as an in-depth investigation of the underlying causes. An additional challenge arises in the form of the excessive practice of phlebotomy during hospitalization for clinical monitoring. Although it is essential to assess the progression of anemia, frequent removal of blood may contribute to iatrogenic anemia, further delaying recovery and possibly increasing susceptibility to infection. patients patient s prognosis determinants loss hemolysis deficiencies marrow presentations procedures particular approach analysis hemoglobin count indepth depth causes monitoring infection
7.
Consensus of the Brazilian association of hematology, hemotherapy and cellular therapy on patient blood management: Anemia tolerance hematology management
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Santis, Gil Cunha De
; Costa, Lorena
; Brunetta, Denise Menezes
; Magnus, Mariana Munari
; Benites, Bruno Deltreggia
; Rodrigues, Roseny dos Reis
; Alves, Susankerle de Oliveira Costa
; Rizzo, Silvia Renata Cornélio Parolin
; Rabello, Guilherme
; Langhi Junior, Dante Mario
.
Abstract Anemia is a pathological condition in which the hemoglobin and red blood cell mass decrease; it is mainly defined by the concentration of hemoglobin in the blood. The World Health Organization guidelines establish specific values to define anemia in different population groups. Early detection of anemia can also be a valuable indicator of underlying medical conditions. Clinical studies have explored the relationship between perioperative anemia and morbidity, highlighting the need for more judicious therapeutic strategies, such as the use of Patient Blood Management, which aims to prevent and treat anemia in a personalized and effective way. Patient Blood Management emerges as a promising approach to dealing with anemia, recognizing that its correction through transfusion always carries risks and that personalized prevention and treatment can offer better outcomes for patients. decrease groups conditions morbidity strategies way patients
8.
Prenylated and Geranylated Derivatives of Non-Oxidized Monomeric Acylphloroglucinols of Natural Origin: Occurrence, Biological Properties and Spectroscopic Data NonOxidized Non Oxidized Origin Occurrence
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Arrospide, Tainá M.
; Sousa, Lucas H. N.
; Diniz, Marcela C. N.
; Menezes, Fabrício G.
; Araújo, Renata M.
.
Phloroglucinols comprise polyphenolic compounds abundantly present in biological systems, which are synthesized and accumulated by plants, microorganisms, and marine organisms of different families. Interesting biological activities are associated with these compounds endowed with unique structural characteristics. Because of this, they have become attractive for studies in several areas, such as chemistry and pharmacology. Despite the existence of reputable reviews on phloroglucinol and its derivative compounds, updates on the subject are constant and there are still unexplored specificities of these polyphenols in the literature. Therefore, the present review compiled data on monomeric derivatives of acylphloroglucinols isolated from natural sources. These compounds were grouped into classes considering the oxidation of the central 1,3,5-trihydroxybenzene (THB) ring. Nuclear magnetic resonance (NMR) spectroscopic data and biological activities reported in the literature were associated with the cataloged metabolites considering publications from 1965 to 2022. systems plants microorganisms families characteristics this areas pharmacology Therefore sources 1,3,5trihydroxybenzene 135trihydroxybenzene trihydroxybenzene 1,3,5 1 3 5 THB (THB ring NMR (NMR 196 2022 5trihydroxybenzene 135 1,3, 19 202 13 1,3 20 1, 2
9.
Fishes of the upper rio Paraná basin: diversity, biogeography and conservation basin diversity
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Dagosta, Fernando Cesar Paiva
; Monção, Maristela Sayure
; Nagamatsu, Bárbara Akemi
; Pavanelli, Carla S.
; Carvalho, Fernando R.
; Lima, Flávio C. T.
; Langeani, Francisco
; Dutra, Guilherme Moreira
; Ota, Renata Rubia
; Seren, Thomaz Jefrey
; Tagliacollo, Victor
; Menezes, Naércio Aquino
; Britski, Heraldo A.
; Pinna, Mário de
.
Resumo A bacia do alto rio Paraná drena a região mais desenvolvida e ambientalmente degradada da América do Sul: o sudeste brasileiro. Ao mesmo tempo que é uma das assembleias de peixes neotropicais mais conhecidas, também é uma das mais ameaçadas pela atividade antrópica. Urbanização, desmatamento, barramentos de usinas, espécies invasoras e poluição da água não apenas reduzem a área de vida das espécies, mas também alteram nossa percepção da bacia e de seus elementos bióticos. Essas mudanças ambientais são tão profundas e abrangentes que geram incertezas sobre a natureza nativa ou não nativa de várias espécies. Este artigo visa oferecer uma visão detalhada da diversidade nativa e da biogeografia histórica dos peixes da bacia do alto rio Paraná, fornecendo uma base sólida para futuras políticas de conservação. Atualizamos a lista de espécies nativas, analisamos distribuições geográficas e identificamos padrões biogeográficos, enfatizando áreas que requerem reconhecimento como biotas distintas para esforços de conservação. Nos últimos 15 anos, mais de 100 espécies adicionais foram descritas ou registradas, expandindo o total para 341 espécies nativas pertencentes a seis ordens e 30 famílias, tornando-a a bacia hidrográfica mais rica do Brasil fora da região amazônica. Ao contrário da maioria das bacias neotropicais em que Characidae domina, os loricariídeos constituem quase um quarto da diversidade total de peixes na região. Espécies e clados se concentram na região central da bacia, enquanto elementos endêmicos estão restritos a áreas periféricas devido à complexa história biogeográfica compartilhada com bacias vizinhas. Dezoito regiões biogeográficas distintas são identificadas, sua composição, biogeografia e conservação são discutidas. A bacia do alto rio Paraná possui 10% de sua ictiofauna classificada como ameaçada e apresenta 128 espécies não nativas, incluindo três híbridos. Isso a posiciona como a drenagem com o maior número de táxons ameaçados nos trópicos ao mesmo tempo que tem a maior riqueza de elementos não nativos. As áreas protegidas existentes são consideradas ineficazes na preservação das diferentes assembleias e falham em proteger a maioria das espécies ameaçadas e as endêmicas. Sul brasileiro conhecidas antrópica Urbanização desmatamento usinas bióticos biogeográficos 1 anos 10 registradas 34 3 famílias tornandoa tornando amazônica domina vizinhas identificadas composição discutidas 12 híbridos nativos endêmicas
Abstract The upper rio Paraná basin drains the most developed and environmentally degraded region in South America: the Brazilian southeast. While it is one of the most well-known Neotropical fish assemblages, it is also one of the most threatened by anthropic activity. Urbanization, deforestation, dam construction, invasive species, and water pollution not only reduce the living area of species but also alter our perception of the basin and its biotic elements. Such changes are so profound and pervasive that raise uncertainties about the native or non-native status of several species. This paper aims to offer a detailed picture of the native diversity and historical biogeography of the fishes in the upper rio Paraná basin, which we hope will offer a solid foundation for future conservation policies. We update the list of native species, analyze geographical distributions, and identify biogeographical patterns, emphasizing areas requiring recognition as distinct biotas for conservation efforts. Over the past 15 years, more than 100 additional species have been described or recorded, expanding the total to 341 native species belonging to six orders and 30 families, making it the richest river basin in Brazil outside the Amazonian region. Unlike most neotropical basins where Characidae dominates, loricariids make up nearly one-fourth of the total fish diversity in the region. Species and clades concentrate in the central basin, while endemics are confined to peripheral areas due to the complex biogeographical history shared with neighboring basins. Eighteen distinct biogeographical regions are identified, discussing their composition, histories, and conservation implications. The upper rio Paraná basin has 10% of its fish fauna ranked as endangered and present 128 non-native species, including three hybrids. This places it as the major drainage with the largest number of endangered taxa in the neotropics and at the same time the one with the most numerous non-native elements. Existing protected areas are deemed ineffective in preserving diverse assemblages and fail to safeguard the majority of threatened and narrowly-endemic species. America southeast wellknown well known activity Urbanization deforestation construction elements nonnative non policies distributions patterns efforts 1 years 10 recorded 34 3 families dominates onefourth fourth identified composition histories implications 12 hybrids narrowlyendemic narrowly endemic
10.
Agronomic performance of beetroot as a function of silicon application
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Lima, Renner Bento de
; Paiva, Laíza Gomes de
; Pereira, Natali Almeida Evangelista
; Morais, Eric George
; Silva, Ilmara Beatriz Menezes
; Grangeiro, Leilson Costa
; Costa, Romualdo Medeiros Cortez
; Oliveira, Renata Ramayane Torquato
.
ABSTRACT Beetroot, when cultivated in hot regions such as the Brazilian semi-arid, is subjected to various stressful environmental factors that can negatively impact its productivity and quality. Silicon is an element known for its ability to mitigate damage caused by both abiotic and biotic stressors and is recognized as a productivity and quality enhancer in agricultural crops. Therefore, this study aimed to evaluate the effects of silicon application on the agronomic performance of the beet crop. The experimental design used was a randomized block design in a 5 x 2 factorial arrangement with four replications, comprising five silicon doses (0.0; 0.9; 1.8; 2.7, and 3.6 kg ha-1) and two table beet cultivars (Fortuna and Maravilha). The assessed variables included plant height, number of leaves per plant, polar and equatorial diameter of the tuberous root, tuberous root, shoot and total dry matter mass, commercial, non-commercial, and total productivity, as well as quality assessment of the root with determinations of pH, vitamin C, titratable acidity, and total soluble sugars. A silicon dose of 2.56 kg ha-1 promoted optimal root development in the Fortuna cultivar; however, silicon application at all tested doses reduced the levels of soluble sugars, while a dose of 3.6 kg ha-1 increased total titratable acidity. In contrast, silicon did not infl uence root development in the Maravilha cultivar, but an application of 3.13 kg ha-1 increased the total soluble sugar content by 86.13%. Beetroot semiarid, semiarid semi arid, arid semi-arid crops Therefore crop replications 0.0 00 0 (0.0 0.9 09 9 1.8 18 1 8 27 7 2.7 36 3 6 3. ha1 ha Maravilha. . Maravilha) height mass commercial noncommercial, noncommercial non non-commercial pH C acidity sugars 256 56 2.5 ha- cultivar however contrast 313 13 3.1 8613 86 86.13% 0. (0. 1. 2. 25 31 861 86.13 (0 86.1 ( 86.
11.
As muitas vidas de um chapéu de Carnaval
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12.
ALCALOIDES SESQUITERPÊNICOS ISOLADOS DE Maytenus distichophylla (CELASTRACEAE) CELASTRACEAE (CELASTRACEAE
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Figueiredo, Pedro Thiago Ramalho de
; Duarte, Marcelo Cavalcante
; Cordeiro, Laísa Vilar
; Menezes, Renata Priscila Barros de
; Lima, Edeltrudes de Oliveira
; Scotti, Marcus Tullius
; Tavares, Josean Fechine
; Costa, Vicente Carlos de Oliveira
; Silva, Marcelo Sobral da
.
SESQUITERPENES ALKALOIDS FROM Maytenus distichophylla (CELASTRACEAE). The phytochemical study of the roots of Maytenus distichophylla Mart. ex Reissek (Celastraceae), resulted in the isolation of the seven sesquiterpenes pyridine alkaloids euojaponine F (1), euojaponine K (2), ebinifoline W-I (3), wilforine (4), maiteine (5), euojaponine A (6) and ebinifoline E-II (7). The structures of compounds were established using spectroscopic techniques such as 1D and 2D NMR. All compounds were subjected to an in silico study through of a predictive model and then submitted to in vitro testing against S. epidermidis, P. aeruginosa, C. parapsilosis and C. albicans for evaluation of their antimicrobial activity. The compounds tested showed bacterial and fungal growth inhibition with MIC values 1024 and 256 µg mL-1, respectively. CELASTRACEAE. CELASTRACEAE . (CELASTRACEAE) Mart Celastraceae, Celastraceae , (Celastraceae) 1, 1 (1) 2, 2 (2) WI W I 3, 3 (3) 4, 4 (4) 5, 5 (5) 6 (6 EII E II 7. 7 (7) D NMR S epidermidis P aeruginosa C activity 102 25 mL1, mL1 mL mL-1 respectively (CELASTRACEAE (Celastraceae (1 (2 (3 (4 (5 ( (7 10 mL-
13.
Impact of Oral Health Conditions on the Quality of Life of Adolescents
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Silva, Thais Carine da
; Menezes, Luma de Vasconcelos
; Sousa, Adelaine Maria
; Lima, Sinara Cunha
; Cimões, Renata
; Vajgel, Bruna de Carvalho Farias
.
Pesquisa Brasileira em Odontopediatria e Clínica Integrada
- Journal Metrics
ABSTRACT Objective: To evaluate oral conditions' impact on school adolescents' quality of life. Material and Methods: This is a cross-sectional, school-based, descriptive, and analytical study. The study's final sample comprised 1,010 adolescents aged between 14 and 19. The dependent variable of oral health-related quality of life (OHRQoL) was measured using the OHIP-14 questionnaire. The independent variables were oral conditions assessed through clinical examination and a questionnaire for the socioeconomic indicators. Descriptive analyses, chi-square, and binary logistic regression were performed, and the significance level adopted was 5%. Results: The impact of oral conditions on OHRQoL was reported by approximately 34% of adolescents. The prevalence of dental caries was 26.2%, periodontal disease 45.8%, dental trauma 38%, and malocclusion was 29.7%. Of the variables analyzed, only sex (p<0.001) and caries experience (p=0.012) were associated with OHRQoL, showing that females are 1.87 times more likely to affect their quality of life than males, and those with caries were 1.46 times more likely to have an impact on the OHRQoL. Conclusion: The sex and experience of caries might be associated with decreasing the quality of life. Objective Methods crosssectional, crosssectional cross sectional, sectional cross-sectional schoolbased, schoolbased based, based school-based descriptive study studys s 1010 1 010 1,01 19 healthrelated health related (OHRQoL OHIP14 OHIP OHIP-1 indicators analyses chisquare, chisquare chi square, square chi-square performed 5 5% Results 34 262 26 2 26.2% 458 45 8 45.8% 38 38% 297 29 7 29.7% analyzed p<0.001 p0001 p 0 001 (p<0.001 p=0.012 p0012 012 (p=0.012 187 87 1.8 males 146 46 1.4 Conclusion 101 01 1,0 OHIP1 OHIP- 3 26.2 4 45.8 29.7 p<0.00 p000 00 (p<0.00 p=0.01 p001 (p=0.01 18 1. 10 1, 26. 45. 29. p<0.0 p00 (p<0.0 p=0.0 (p=0.0 p<0. p0 (p<0. p=0. (p=0. p<0 (p<0 p=0 (p=0 p< (p< p= (p= (p
14.
Catálogo Taxonômico da Fauna do Brasil: Setting the baseline knowledge on the animal diversity in Brazil Brasil
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Boeger, Walter A.
; Valim, Michel P.
; Zaher, Hussam
; Rafael, José A.
; Forzza, Rafaela C.
; Percequillo, Alexandre R.
; Serejo, Cristiana S.
; Garraffoni, André R.S.
; Santos, Adalberto J.
; Slipinski, Adam
; Linzmeier, Adelita M.
; Calor, Adolfo R.
; Garda, Adrian A.
; Kury, Adriano B.
; Fernandes, Agatha C.S.
; Agudo-Padrón, Aisur I.
; Akama, Alberto
; Silva Neto, Alberto M. da
; Burbano, Alejandro L.
; Menezes, Aleksandra
; Pereira-Colavite, Alessandre
; Anichtchenko, Alexander
; Lees, Alexander C.
; Bezerra, Alexandra M.R.
; Domahovski, Alexandre C.
; Pimenta, Alexandre D.
; Aleixo, Alexandre L.P.
; Marceniuk, Alexandre P.
; Paula, Alexandre S. de
; Somavilla, Alexandre
; Specht, Alexandre
; Camargo, Alexssandro
; Newton, Alfred F.
; Silva, Aline A.S. da
; Santos, Aline B. dos
; Tassi, Aline D.
; Aragão, Allan C.
; Santos, Allan P.M.
; Migotto, Alvaro E.
; Mendes, Amanda C.
; Cunha, Amanda
; Chagas Júnior, Amazonas
; Sousa, Ana A.T. de
; Pavan, Ana C.
; Almeida, Ana C.S.
; Peronti, Ana L.B.G.
; Henriques-Oliveira, Ana L.
; Prudente, Ana L.
; Tourinho, Ana L.
; Pes, Ana M.O.
; Carmignotto, Ana P.
; Wengrat, Ana P.G. da Silva
; Dornellas, Ana P.S.
; Molin, Anamaria Dal
; Puker, Anderson
; Morandini, André C.
; Ferreira, André da S.
; Martins, André L.
; Esteves, André M.
; Fernandes, André S.
; Roza, André S.
; Köhler, Andreas
; Paladini, Andressa
; Andrade, Andrey J. de
; Pinto, Ângelo P.
; Salles, Anna C. de A.
; Gondim, Anne I.
; Amaral, Antonia C.Z.
; Rondón, Antonio A.A.
; Brescovit, Antonio
; Lofego, Antônio C.
; Marques, Antonio C.
; Macedo, Antonio
; Andriolo, Artur
; Henriques, Augusto L.
; Ferreira Júnior, Augusto L.
; Lima, Aurino F. de
; Barros, Ávyla R. de A.
; Brito, Ayrton do R.
; Romera, Bárbara L.V.
; Vasconcelos, Beatriz M.C. de
; Frable, Benjamin W.
; Santos, Bernardo F.
; Ferraz, Bernardo R.
; Rosa, Brunno B.
; Sampaio, Brunno H.L.
; Bellini, Bruno C.
; Clarkson, Bruno
; Oliveira, Bruno G. de
; Corrêa, Caio C.D.
; Martins, Caleb C.
; Castro-Guedes, Camila F. de
; Souto, Camilla
; Bicho, Carla de L.
; Cunha, Carlo M.
; Barboza, Carlos A. de M.
; Lucena, Carlos A.S. de
; Barreto, Carlos
; Santana, Carlos D.C.M. de
; Agne, Carlos E.Q.
; Mielke, Carlos G.C.
; Caetano, Carlos H.S.
; Flechtmann, Carlos H.W.
; Lamas, Carlos J.E.
; Rocha, Carlos
; Mascarenhas, Carolina S.
; Margaría, Cecilia B.
; Waichert, Cecilia
; Digiani, Celina
; Haddad, Célio F.B.
; Azevedo, Celso O.
; Benetti, Cesar J.
; Santos, Charles M.D. dos
; Bartlett, Charles R.
; Bonvicino, Cibele
; Ribeiro-Costa, Cibele S.
; Santos, Cinthya S.G.
; Justino, Cíntia E.L.
; Canedo, Clarissa
; Bonecker, Claudia C.
; Santos, Cláudia P.
; Carvalho, Claudio J.B. de
; Gonçalves, Clayton C.
; Galvão, Cleber
; Costa, Cleide
; Oliveira, Cléo D.C. de
; Schwertner, Cristiano F.
; Andrade, Cristiano L.
; Pereira, Cristiano M.
; Sampaio, Cristiano
; Dias, Cristina de O.
; Lucena, Daercio A. de A.
; Manfio, Daiara
; Amorim, Dalton de S.
; Queiroz, Dalva L. de
; Queiroz, Dalva L. de
; Colpani, Daniara
; Abbate, Daniel
; Aquino, Daniel A.
; Burckhardt, Daniel
; Cavallari, Daniel C.
; Prado, Daniel de C. Schelesky
; Praciano, Daniel L.
; Basílio, Daniel S.
; Bená, Daniela de C.
; Toledo, Daniela G.P. de
; Takiya, Daniela M.
; Fernandes, Daniell R.R.
; Ament, Danilo C.
; Cordeiro, Danilo P.
; Silva, Darliane E.
; Pollock, Darren A.
; Muniz, David B.
; Gibson, David I.
; Nogueira, David S.
; Marques, Dayse W.A.
; Lucatelli, Débora
; Garcia, Deivys M.A.
; Baêta, Délio
; Ferreira, Denise N.M.
; Rueda-Ramírez, Diana
; Fachin, Diego A.
; Souza, Diego de S.
; Rodrigues, Diego F.
; Pádua, Diego G. de
; Barbosa, Diego N.
; Dolibaina, Diego R.
; Amaral, Diogo C.
; Chandler, Donald S.
; Maccagnan, Douglas H.B.
; Caron, Edilson
; Carvalho, Edrielly
; Adriano, Edson A.
; Abreu Júnior, Edson F. de
; Pereira, Edson H.L.
; Viegas, Eduarda F.G.
; Carneiro, Eduardo
; Colley, Eduardo
; Eizirik, Eduardo
; Santos, Eduardo F. dos
; Shimbori, Eduardo M.
; Suárez-Morales, Eduardo
; Arruda, Eliane P. de
; Chiquito, Elisandra A.
; Lima, Élison F.B.
; Castro, Elizeu B. de
; Orlandin, Elton
; Nascimento, Elynton A. do
; Razzolini, Emanuel
; Gama, Emanuel R.R.
; Araujo, Enilma M. de
; Nishiyama, Eric Y.
; Spiessberger, Erich L.
; Santos, Érika C.L. dos
; Contreras, Eugenia F.
; Galati, Eunice A.B.
; Oliveira Junior, Evaldo C. de
; Gallardo, Fabiana
; Hernandes, Fabio A.
; Lansac-Tôha, Fábio A.
; Pitombo, Fabio B.
; Dario, Fabio Di
; Santos, Fábio L. dos
; Mauro, Fabio
; Nascimento, Fabio O. do
; Olmos, Fabio
; Amaral, Fabio R.
; Schunck, Fabio
; Godoi, Fábio S. P. de
; Machado, Fabrizio M.
; Barbo, Fausto E.
; Agrain, Federico A.
; Ribeiro, Felipe B.
; Moreira, Felipe F.F.
; Barbosa, Felipe F.
; Silva, Fenanda S.
; Cavalcanti, Fernanda F.
; Straube, Fernando C.
; Carbayo, Fernando
; Carvalho Filho, Fernando
; Zanella, Fernando C.V.
; Jacinavicius, Fernando de C.
; Farache, Fernando H.A.
; Leivas, Fernando
; Dias, Fernando M.S.
; Mantellato, Fernando
; Vaz-de-Mello, Fernando Z.
; Gudin, Filipe M.
; Albuquerque, Flávio
; Molina, Flavio B.
; Passos, Flávio D.
; Shockley, Floyd W.
; Pinheiro, Francielly F.
; Mello, Francisco de A.G. de
; Nascimento, Francisco E. de L.
; Franco, Francisco L.
; Oliveira, Francisco L. de
; Melo, Francisco T. de V.
; Quijano, Freddy R.B.
; Salles, Frederico F.
; Biffi, Gabriel
; Queiroz, Gabriel C.
; Bizarro, Gabriel L.
; Hrycyna, Gabriela
; Leviski, Gabriela
; Powell, Gareth S.
; Santos, Geane B. dos
; Morse, Geoffrey E.
; Brown, George
; Mattox, George M.T.
; Zimbrão, Geraldo
; Carvalho, Gervásio S.
; Miranda, Gil F.G.
; Moraes, Gilberto J. de
; Lourido, Gilcélia M.
; Neves, Gilmar P.
; Moreira, Gilson R.P.
; Montingelli, Giovanna G.
; Maurício, Giovanni N.
; Marconato, Gláucia
; Lopez, Guilherme E.L.
; Silva, Guilherme L. da
; Muricy, Guilherme
; Brito, Guilherme R.R.
; Garbino, Guilherme S.T.
; Flores, Gustavo E.
; Graciolli, Gustavo
; Libardi, Gustavo S.
; Proctor, Heather C.
; Gil-Santana, Helcio R.
; Varella, Henrique R.
; Escalona, Hermes E.
; Schmitz, Hermes J.
; Rodrigues, Higor D.D.
; Galvão Filho, Hilton de C.
; Quintino, Hingrid Y.S.
; Pinto, Hudson A.
; Rainho, Hugo L.
; Miyahira, Igor C.
; Gonçalves, Igor de S.
; Martins, Inês X.
; Cardoso, Irene A.
; Oliveira, Ismael B. de
; Franz, Ismael
; Fernandes, Itanna O.
; Golfetti, Ivan F.
; S. Campos-Filho, Ivanklin
; Oliveira, Ivo de S.
; Delabie, Jacques H.C.
; Oliveira, Jader de
; Prando, Jadila S.
; Patton, James L.
; Bitencourt, Jamille de A.
; Silva, Janaina M.
; Santos, Jandir C.
; Arruda, Janine O.
; Valderrama, Jefferson S.
; Dalapicolla, Jeronymo
; Oliveira, Jéssica P.
; Hájek, Jiri
; Morselli, João P.
; Narita, João P.
; Martin, João P.I.
; Grazia, Jocélia
; McHugh, Joe
; Cherem, Jorge J.
; Farias Júnior, José A.S.
; Fernandes, Jose A.M.
; Pacheco, José F.
; Birindelli, José L.O.
; Rezende, José M.
; Avendaño, Jose M.
; Duarte, José M. Barbanti
; Ribeiro, José R. Inácio
; Mermudes, José R.M.
; Pujol-Luz, José R.
; Santos, Josenilson R. dos
; Câmara, Josenir T.
; Teixeira, Joyce A.
; Prado, Joyce R. do
; Botero, Juan P.
; Almeida, Julia C.
; Kohler, Julia
; Gonçalves, Julia P.
; Beneti, Julia S.
; Donahue, Julian P.
; Alvim, Juliana
; Almeida, Juliana C.
; Segadilha, Juliana L.
; Wingert, Juliana M.
; Barbosa, Julianna F.
; Ferrer, Juliano
; Santos, Juliano F. dos
; Kuabara, Kamila M.D.
; Nascimento, Karine B.
; Schoeninger, Karine
; Campião, Karla M.
; Soares, Karla
; Zilch, Kássia
; Barão, Kim R.
; Teixeira, Larissa
; Sousa, Laura D. do N.M. de
; Dumas, Leandro L.
; Vieira, Leandro M.
; Azevedo, Leonardo H.G.
; Carvalho, Leonardo S.
; Souza, Leonardo S. de
; Rocha, Leonardo S.G.
; Bernardi, Leopoldo F.O.
; Vieira, Letícia M.
; Johann, Liana
; Salvatierra, Lidianne
; Oliveira, Livia de M.
; Loureiro, Lourdes M.A. El-moor
; Barreto, Luana B.
; Barros, Luana M.
; Lecci, Lucas
; Camargos, Lucas M. de
; Lima, Lucas R.C.
; Almeida, Lucia M.
; Martins, Luciana R.
; Marinoni, Luciane
; Moura, Luciano de A.
; Lima, Luciano
; Naka, Luciano N.
; Miranda, Lucília S.
; Salik, Lucy M.
; Bezerra, Luis E.A.
; Silveira, Luis F.
; Campos, Luiz A.
; Castro, Luiz A.S. de
; Pinho, Luiz C.
; Silveira, Luiz F.L.
; Iniesta, Luiz F.M.
; Tencatt, Luiz F.C.
; Simone, Luiz R.L.
; Malabarba, Luiz R.
; Cruz, Luiza S. da
; Sekerka, Lukas
; Barros, Lurdiana D.
; Santos, Luziany Q.
; Skoracki, Maciej
; Correia, Maira A.
; Uchoa, Manoel A.
; Andrade, Manuella F.G.
; Hermes, Marcel G.
; Miranda, Marcel S.
; Araújo, Marcel S. de
; Monné, Marcela L.
; Labruna, Marcelo B.
; Santis, Marcelo D. de
; Duarte, Marcelo
; Knoff, Marcelo
; Nogueira, Marcelo
; Britto, Marcelo R. de
; Melo, Marcelo R.S. de
; Carvalho, Marcelo R. de
; Tavares, Marcelo T.
; Kitahara, Marcelo V.
; Justo, Marcia C.N.
; Botelho, Marcia J.C.
; Couri, Márcia S.
; Borges-Martins, Márcio
; Felix, Márcio
; Oliveira, Marcio L. de
; Bologna, Marco A.
; Gottschalk, Marco S.
; Tavares, Marcos D.S.
; Lhano, Marcos G.
; Bevilaqua, Marcus
; Santos, Marcus T.T.
; Domingues, Marcus V.
; Sallum, Maria A.M.
; Digiani, María C.
; Santarém, Maria C.A.
; Nascimento, Maria C. do
; Becerril, María de los A.M.
; Santos, Maria E.A. dos
; Passos, Maria I. da S. dos
; Felippe-Bauer, Maria L.
; Cherman, Mariana A.
; Terossi, Mariana
; Bartz, Marie L.C.
; Barbosa, Marina F. de C.
; Loeb, Marina V.
; Cohn-Haft, Mario
; Cupello, Mario
; Martins, Marlúcia B.
; Christofersen, Martin L.
; Bento, Matheus
; Rocha, Matheus dos S.
; Martins, Maurício L.
; Segura, Melissa O.
; Cardenas, Melissa Q.
; Duarte, Mércia E.
; Ivie, Michael A.
; Mincarone, Michael M.
; Borges, Michela
; Monné, Miguel A.
; Casagrande, Mirna M.
; Fernandez, Monica A.
; Piovesan, Mônica
; Menezes, Naércio A.
; Benaim, Natalia P.
; Reategui, Natália S.
; Pedro, Natan C.
; Pecly, Nathalia H.
; Ferreira Júnior, Nelson
; Silva Júnior, Nelson J. da
; Perioto, Nelson W.
; Hamada, Neusa
; Degallier, Nicolas
; Chao, Ning L.
; Ferla, Noeli J.
; Mielke, Olaf H.H.
; Evangelista, Olivia
; Shibatta, Oscar A.
; Oliveira, Otto M.P.
; Albornoz, Pablo C.L.
; Dellapé, Pablo M.
; Gonçalves, Pablo R.
; Shimabukuro, Paloma H.F.
; Grossi, Paschoal
; Rodrigues, Patrícia E. da S.
; Lima, Patricia O.V.
; Velazco, Paul
; Santos, Paula B. dos
; Araújo, Paula B.
; Silva, Paula K.R.
; Riccardi, Paula R.
; Garcia, Paulo C. de A.
; Passos, Paulo G.H.
; Corgosinho, Paulo H.C.
; Lucinda, Paulo
; Costa, Paulo M.S.
; Alves, Paulo P.
; Roth, Paulo R. de O.
; Coelho, Paulo R.S.
; Duarte, Paulo R.M.
; Carvalho, Pedro F. de
; Gnaspini, Pedro
; Souza-Dias, Pedro G.B.
; Linardi, Pedro M.
; Bartholomay, Pedro R.
; Demite, Peterson R.
; Bulirsch, Petr
; Boll, Piter K.
; Pereira, Rachel M.M.
; Silva, Rafael A.P.F.
; Moura, Rafael B. de
; Boldrini, Rafael
; Silva, Rafaela A. da
; Falaschi, Rafaela L.
; Cordeiro, Ralf T.S.
; Mello, Ramon J.C.L.
; Singer, Randal A.
; Querino, Ranyse B.
; Heleodoro, Raphael A.
; Castilho, Raphael de C.
; Constantino, Reginaldo
; Guedes, Reinaldo C.
; Carrenho, Renan
; Gomes, Renata S.
; Gregorin, Renato
; Machado, Renato J.P.
; Bérnils, Renato S.
; Capellari, Renato S.
; Silva, Ricardo B.
; Kawada, Ricardo
; Dias, Ricardo M.
; Siewert, Ricardo
; Brugnera, Ricaro
; Leschen, Richard A.B.
; Constantin, Robert
; Robbins, Robert
; Pinto, Roberta R.
; Reis, Roberto E. dos
; Ramos, Robson T. da C.
; Cavichioli, Rodney R.
; Barros, Rodolfo C. de
; Caires, Rodrigo A.
; Salvador, Rodrigo B.
; Marques, Rodrigo C.
; Araújo, Rodrigo C.
; Araujo, Rodrigo de O.
; Dios, Rodrigo de V.P.
; Johnsson, Rodrigo
; Feitosa, Rodrigo M.
; Hutchings, Roger W.
; Lara, Rogéria I.R.
; Rossi, Rogério V.
; Gerstmeier, Roland
; Ochoa, Ronald
; Hutchings, Rosa S.G.
; Ale-Rocha, Rosaly
; Rocha, Rosana M. da
; Tidon, Rosana
; Brito, Rosangela
; Pellens, Roseli
; Santos, Sabrina R. dos
; Santos, Sandra D. dos
; Paiva, Sandra V.
; Santos, Sandro
; Oliveira, Sarah S. de
; Costa, Sávio C.
; Gardner, Scott L.
; Leal, Sebastián A. Muñoz
; Aloquio, Sergio
; Bonecker, Sergio L.C.
; Bueno, Sergio L. de S.
; Almeida, Sérgio M. de
; Stampar, Sérgio N.
; Andena, Sérgio R.
; Posso, Sergio R.
; Lima, Sheila P.
; Gadelha, Sian de S.
; Thiengo, Silvana C.
; Cohen, Simone C.
; Brandão, Simone N.
; Rosa, Simone P.
; Ribeiro, Síria L.B.
; Letana, Sócrates D.
; Santos, Sonia B. dos
; Andrade, Sonia C.S.
; Dávila, Stephane
; Vaz, Stéphanie
; Peck, Stewart B.
; Christo, Susete W.
; Cunha, Suzan B.Z.
; Gomes, Suzete R.
; Duarte, Tácio
; Madeira-Ott, Taís
; Marques, Taísa
; Roell, Talita
; Lima, Tarcilla C. de
; Sepulveda, Tatiana A.
; Maria, Tatiana F.
; Ruschel, Tatiana P.
; Rodrigues, Thaiana
; Marinho, Thais A.
; Almeida, Thaís M. de
; Miranda, Thaís P.
; Freitas, Thales R.O.
; Pereira, Thalles P.L.
; Zacca, Thamara
; Pacheco, Thaynara L.
; Martins, Thiago F.
; Alvarenga, Thiago M.
; Carvalho, Thiago R. de
; Polizei, Thiago T.S.
; McElrath, Thomas C.
; Henry, Thomas
; Pikart, Tiago G.
; Porto, Tiago J.
; Krolow, Tiago K.
; Carvalho, Tiago P.
; Lotufo, Tito M. da C.
; Caramaschi, Ulisses
; Pinheiro, Ulisses dos S.
; Pardiñas, Ulyses F.J.
; Maia, Valéria C.
; Tavares, Valeria
; Costa, Valmir A.
; Amaral, Vanessa S. do
; Silva, Vera C.
; Wolff, Vera R. dos S.
; Slobodian, Verônica
; Silva, Vinícius B. da
; Espíndola, Vinicius C.
; Costa-Silva, Vinicius da
; Bertaco, Vinicius de A.
; Padula, Vinícius
; Ferreira, Vinicius S.
; Silva, Vitor C.P. da
; Piacentini, Vítor de Q.
; Sandoval-Gómez, Vivian E.
; Trevine, Vivian
; Sousa, Viviane R.
; Sant’Anna, Vivianne B. de
; Mathis, Wayne N.
; Souza, Wesley de O.
; Colombo, Wesley D.
; Tomaszewska, Wioletta
; Wosiacki, Wolmar B.
; Ovando, Ximena M.C.
; Leite, Yuri L.R.
.
ABSTRACT The limited temporal completeness and taxonomic accuracy of species lists, made available in a traditional manner in scientific publications, has always represented a problem. These lists are invariably limited to a few taxonomic groups and do not represent up-to-date knowledge of all species and classifications. In this context, the Brazilian megadiverse fauna is no exception, and the Catálogo Taxonômico da Fauna do Brasil (CTFB) (http://fauna.jbrj.gov.br/), made public in 2015, represents a database on biodiversity anchored on a list of valid and expertly recognized scientific names of animals in Brazil. The CTFB is updated in near real time by a team of more than 800 specialists. By January 1, 2024, the CTFB compiled 133,691 nominal species, with 125,138 that were considered valid. Most of the valid species were arthropods (82.3%, with more than 102,000 species) and chordates (7.69%, with over 11,000 species). These taxa were followed by a cluster composed of Mollusca (3,567 species), Platyhelminthes (2,292 species), Annelida (1,833 species), and Nematoda (1,447 species). All remaining groups had less than 1,000 species reported in Brazil, with Cnidaria (831 species), Porifera (628 species), Rotifera (606 species), and Bryozoa (520 species) representing those with more than 500 species. Analysis of the CTFB database can facilitate and direct efforts towards the discovery of new species in Brazil, but it is also fundamental in providing the best available list of valid nominal species to users, including those in science, health, conservation efforts, and any initiative involving animals. The importance of the CTFB is evidenced by the elevated number of citations in the scientific literature in diverse areas of biology, law, anthropology, education, forensic science, and veterinary science, among others. publications problem uptodate up date classifications context exception (CTFB http//fauna.jbrj.gov.br/, httpfaunajbrjgovbr http //fauna.jbrj.gov.br/ , jbrj gov br (http://fauna.jbrj.gov.br/) 2015 Brazil 80 specialists 1 2024 133691 133 691 133,69 125138 125 138 125,13 82.3%, 823 82 3 (82.3% 102000 102 000 102,00 7.69%, 769 7 69 (7.69% 11000 11 11,00 . 3,567 3567 567 (3,56 2,292 2292 2 292 (2,29 1,833 1833 833 (1,83 1,447 1447 447 (1,44 1000 1,00 831 (83 628 (62 606 (60 520 (52 50 users science health biology law anthropology education others http//fauna.jbrj.gov.br/ faunajbrjgovbr //fauna.jbrj.gov.br (http://fauna.jbrj.gov.br/ 201 8 202 13369 13 133,6 12513 12 125,1 82.3% (82.3 10200 10 00 102,0 7.69% 76 6 (7.69 1100 11,0 3,56 356 56 (3,5 2,29 229 29 (2,2 1,83 183 83 (1,8 1,44 144 44 (1,4 100 1,0 (8 62 (6 60 52 (5 5 http//fauna.jbrj.gov.br (http://fauna.jbrj.gov.br 20 1336 133, 1251 125, 82.3 (82. 1020 0 102, 7.69 (7.6 110 11, 3,5 35 (3, 2,2 22 (2, 1,8 18 (1, 1,4 14 4 ( 82. (82 7.6 (7. 3, (3 2, (2 (1 7. (7
15.
Niobium/Hydroxyapatite Composite as a Potential Stimulator of Bone Formation in Critical Size Calvarial Defects in Rats NiobiumHydroxyapatite Niobium Hydroxyapatite
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Silva, Salomé Ribeiro da
; Martins, Agnes Andrade
; Melo, Rômulo Camilo de Oliveira
; Araújo, Valkleidson Santos
; Silva, Davi Neto de Araújo
; Chalmers, Jaclyn
; Silveira, Taciane Menezes da
; Pirih, Flavia Queiroz
; Andrade, Raphael Victor Silva
; Silva, Rafaela Alcindo
; Silva, José Sandro Pereira da
; Delmonte, Mauricio Roberto Bomio
; Motta, Fabiana Villela
; Castro, Mario Andrean Macedo
; Lopes, Maria Luiza Diniz de Sousa
; Leitão, Renata Ferreira Carvalho
; Araújo Júnior, Raimundo Fernandes de
; Clebis, Naianne Kelly
; Araújo, Aurigena Antunes de
.
Abstract This study aimed to analyze the physical features and effect of hydroxyapatite (HAp) and Niobium/HAp CaNb2O6/Ca3(PO4)2 composite on critical size defect in rat calvaria. Biomaterials were characterized by X-ray diffraction (XRD), X-ray fluorescence (XRF), Particle size distribution (PSD) and Scanning Electron Microscopy (SEM). Critical size (8 mm) calvarial defects were created in Wistar rats (n = 24) distributed in three groups (90 days): Control group (CG): critical defect no treatment; HAp group: Hydroxyapatite; CNb/CPO group: CaNb2O6/Ca3(PO4)2 composite. After 90 days, calvaria samples were subjected to histological, and immunohistochemical reactions for osteopontin and osteocalcin, and Micro-CT analyses. XRD analysis confirmed the formation of a crystalline structure of CNb/CPO. XRF measurements confirmed the presence of Nb added in the sample CNb/CPO. Fracture toughness from CNb/CPO composite was 0.82 MPa.m1/2. Micro-CT showed increased trabecular number (p˂0.001), decreased porosities (%) (p˂0.001) and decreased trabecular separation (mm) (p˂0.001) in the CNb/CPO compared to CG group. In CNb/CPO group showed presence of new bone in which connective tissue differentiates to form or indicate a bone matrix score 3 (3-3.75, p˂0.05) and strong immunoexpression of osteopontin (p<0.05). The findings indicate that CNb/CPO showed resistance to the propagation of cracks and stimulated bone formation in calvaria defects in rats. (HAp NiobiumHAp Niobium CaNb2O6/Ca3PO42 CaNb2O6Ca3PO42 CaNbOCaPO CaNb2O6/Ca3 PO4 2 CaNb2O6 Ca3 CaNb O Ca PO CaNb2O6/Ca3(PO4) Xray X ray XRD, , (XRD) XRF, (XRF) PSD (PSD SEM. SEM . (SEM) 8 ( mm n 24 (9 days days) (CG) treatment Hydroxyapatite CNbCPO CNb CPO 9 histological osteocalcin MicroCT Micro CT analyses 082 0 82 0.8 MPam12 MPam MPa m1 m MPa.m1/2 p˂0.001, p0001 p p˂0.001 001 % (% (p˂0.001 (mm 33.75, 3375 3.75, 75 (3-3.75 p˂0.05 p005 05 p<0.05. p<0.05 (p<0.05) Ca3PO42 CaNb2O6/Ca3PO4 CaNb2O6Ca3PO4 CaNb2O6Ca3 CaNbOCa CaNb2O6/Ca CaNbO CaNb2O CaNb2O6/Ca3(PO4 (XRD (XRF (SEM (CG 08 0. MPam1 MPa.m1/ p000 p˂0.00 00 (p˂0.00 33 33.75 337 375 3.75 7 (3-3.7 p˂0.0 p00 p<0.0 (p<0.05 CaPO Ca3PO4 CaNb2O6/Ca3PO CaNb2O6Ca3PO CaNb2O6Ca CaNb2O6/Ca3(PO MPa.m1 (p˂0.0 33.7 37 3.7 (3-3. p˂0. p0 p<0. (p<0.0 Ca3PO MPa.m (p˂0. 33. 3. (3-3 p˂0 p<0 (p<0. (p˂0 (3- p˂ p< (p<0 (p˂ (3 (p< (p
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