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Intervenção precoce com crianças e famílias: desafio colaborativo para o serviço social famílias
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Menezes, Manuel

; Ribeiro, Eugénia

Revista Katálysis

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2024, Volume 27 elocation e95113

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Neste ensaio realizamos uma autorreflexão da intervenção do Serviço Social na ANIP em famílias com crianças expostas a fatores de risco ambiental. Procedemos a uma revisão sistemática da literatura, salientando: (i) a importância da abordagem centrada na família e as suas interligações com as perspetivas dos sistemas transacional/ecológico e (ii) o contributo dos conceitos de Enabling/Empowering Families para a mudança de paradigma e, consequente, substituição de modelos clínicos/assistencialistas por uma intervenção onde a família emerge como elemento ativo/fundamental nos processos de mudança. Dos resultados destacamos: (i) os desafios colocados aos profissionais na implementação de práticas colaborativas junto das famílias e (ii) as exigências do trabalho em equipe de intervenção precoce, tanto ao nível do conhecimento dos referenciais teóricos subjacentes à mediação com famílias, como da capacitação para, quando em face de circunstâncias concretas, tomar decisões baseadas na evidência e nas especificidades das crianças/famílias, por forma a melhor responder às suas necessidades singulares. ambiental literatura salientando i (i transacionalecológico transacional ecológico ii (ii EnablingEmpowering Enabling Empowering consequente clínicosassistencialistas clínicos assistencialistas ativofundamental ativo fundamental destacamos precoce concretas criançasfamílias crianças/famílias singulares

Abstract In this essay, we carry out a self-reflection on the intervention of Social Work in ANIP in families with children exposed to environmental risk factors. We conducted a systematic review of the literature, highlighting (i) the importance of the family-centered approach and its interconnections with the transactional/ecological systems perspectives and (ii) the contribution of the concepts of Enabling/Empowering Families to the paradigm shift and, consequently, the replacement of clinical/welfare models with an intervention in which the family emerges as an active/fundamental element in the processes of change. From the results, we can highlight (i) the challenges for professionals in implementing collaborative practices with families and (ii) the demands of working in an early intervention team, both in terms of knowledge of the theoretical frameworks underlying mediation with families and in terms of training to make decisions based on evidence and the specificities of children/families when faced with concrete circumstances, in order to better respond to their unique needs. essay selfreflection self reflection factors literature i (i familycentered centered transactionalecological transactional ecological ii (ii EnablingEmpowering Enabling Empowering consequently clinicalwelfare clinical welfare activefundamental active fundamental change results team childrenfamilies circumstances needs

https://doi.org/10.1590/1982-0259.2024.e95113

Seed quality parameters for selection of Handroanthus serratifolius (Vahl) S. Grose mother trees in western Amazonia Vahl (Vahl S
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Silva Junior, Israel

; Lima Junior, Manuel de Jesus Vieira

; Mendes, Angela Maria da Silva

; Bastos, Lydiane Lucia de Sousa

; Menezes, Valdiek da Silva

Ciência Florestal

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2024, Volume 34 N. 4 elocation e84834

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Handroanthus serratifolius é reconhecida pelo potencial madeireiro e na arborização urbana. No entanto, sua exploração indiscriminada tem ameaçado a espécie para risco de extinção. Nosso objetivo foi padronizar os parâmetros mais representativos de qualidade para espécie, os quais são determinantes para o processo de identificação de lotes de sementes vigorosos. Buscamos otimizar a produção de sementes e minimizar perdas de material genético, indicar as melhores variáveis tecnológicas, morfológicas e biométricas e sua correlação com as matrizes. Para isso, os lotes de sementes foram coletados de 20 matrizes identificadas por Áreas de Coletas de Sementes. Para cada lote, foram analisadas as características físicas, morfológicas, dendrométricas e tecnológicas das sementes. Através da matriz de correlação, foi observado que as características dendrométricas não influenciaram nas características de vigor das sementes. Dentre as variáveis analisadas, o peso de mil sementes (PMS) apresentou correlação com as características biométricas e com a formação de plântulas. Sendo, portanto, o PMS e as características biométricas as variáveis que melhor explicaram o comportamento da população. O coeficiente de repetibilidade demonstrou que 14 sementes são suficientes para determinar as características biométricas de um lote de H. serratifolius. Houve variabilidade dentro da população, com oito árvores matrizes apresentando características superiores de vigor e cinco apresentaram alto valor (> 58%) para emergência de plântula. urbana entanto extinção vigorosos genético isso 2 Sementes físicas (PMS plântulas Sendo portanto população 1 H > ( 58% 58 plântula 5

ABSTRACT Handroanthus serratifolius is recognized for its timber potential and for planting in urban areas. However, its indiscriminate exploitation threatens the species with extinction. Our objective was to standardize the most representative parameters of quality for the species, which are necessary for the identification of vigor in seedlots. We sought to optimize seed production and minimize losses of genetic material and indicate the best technological, morphological and biometric variables and their correlation with the mother trees. For this, seedlots were collected from 20 mother trees identified in seed collection areas. For each batch, the physical, morphological, dendrometric and technological characteristics of the seeds were analyzed. Via the correlation matrix, it was observed that the dendrometric characteristics did not influence the characteristics of seed vigor. Among the variables analyzed, the weight of one thousand seeds (WTS) correlated with biometric characteristics and seedling formation. Therefore, WTS and biometric characteristics were the variables that best explained the behavior of the population. The repeatability coefficient demonstrated that 14 seeds are sufficient to characterize the biometric characteristics of a seedlot of H. serratifolius. Variability was observed within the population, with eight parent trees presenting superior characteristics for vigor and five presented a high value (> 58%) for seedling emergence. areas However extinction this 2 batch physical analyzed matrix (WTS formation Therefore population 1 H > ( 58% 58 emergence 5

https://doi.org/10.5902/1980509884834

Predictive factors for the diagnosis of permanent congenital hypothyroidism and its temporal changes in Sergipe, Brazil – A real-life retrospective study Sergipe reallife real life
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Gumes-Felix, Hérika M.

; Ramalho, Roberto J. R.

; Melo, Enaldo V.

; Matos, Diana M.

; Menezes, Nelmo V.

; Oliveira, Carla R. P.

; Campos, Viviane C.

; Santos, Elenilde G.

; Marques, Daniela da S.

; Santos, Brenda Vaz dos

; Andrade, Bruna M. R. de

; Aguiar-Oliveira, Manuel H.

Archives of Endocrinology and Metabolism

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2023, Volume 67 N. 2 Pages 189 - 196

Abstract: En | Text: En | PDF: En

ABSTRACT Objectives: Congenital hypothyroidism (CH) can be permanent (PCH) or transient (TCH). While the importance of thyroxine in myelination of the brain is undisputed, the benefits to neurodevelopmental outcomes of TCH treatment are controversial. Our objectives were to determine predictive factors for PCH and verify its prevalence changes over time. Subjects and methods: A total of 165 children were evaluated at 3 years of age to verify the diagnosis of PCH. 130 were submitted to a two-step cluster analysis, with the aim of grouping them into homogeneous clusters. The mean incidence of PCH and TCH was calculated from 2004 to 2010 and 2011 to 2015. Results: Sixty-six children were diagnosed with PCH, and 99 were diagnosed with TCH. Eighty-one percent of PCH children and all TCH children with thyroid imaging had glands in situ. Eighty children (61.5%) were in Cluster 1, 8 children (6.2%) were in Cluster 2 and 42 children (32.3%) were in Cluster 3. No children had PCH in Cluster 1, while 87.5% of children in Cluster 2 and all children in Cluster 3 had PCH. The most important predictor for PCH was the initial serum TSH, which was marginally higher in importance than the blood spot TSH, followed by the initial serum free T4. The mean incidence of PCH (odds ratio: 1.95, 95% CI 1.36 to 2.95, p < 0.0001) and TCH (odds ratio 1.33, 95%, CI 1.02 to 1.77, p = 0,038) increased over time. Conclusions: The most important PCH predictors are the initial serum TSH and the blood spot TSH. The mean incidence of both PCH and TCH in our series increased. Objectives CH (CH (PCH . (TCH) undisputed controversial time methods 16 13 twostep two step analysis clusters 200 201 2015 Results Sixtysix Sixty six 9 Eightyone one situ 61.5% 615 61 5 (61.5% 1 6.2% 62 6 (6.2% 4 32.3% 323 32 (32.3% 875 87 87.5 T4 T odds 195 95 1.95 136 36 1.3 295 2.95 0.0001 00001 0 0001 133 33 1.33 102 02 1.0 177 77 1.77 0,038 0038 038 Conclusions (TCH 20 61.5 (61.5 6.2 (6.2 32.3 (32.3 87. 19 1.9 1. 29 2.9 0.000 0000 000 10 17 7 1.7 0,03 003 03 61. (61. 6. (6. 32. (32. 2. 0.00 00 0,0 (61 (6 (32 0.0 0, ( (3 0.

https://doi.org/10.20945/2359-3997000000579

Estado e sociedade na construção de capacidades para fortalecer práticas de governança territorial
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Dallabrida, Valdir Roque

; Büttenbender, Pedro Luís

; Covas, António Manuel Alhinho

; Covas, Maria das Mercês Cabrita de Mendonça

; Costamagna, Pablo

; Menezes, Elaine Cristina de Oliveira

Revista Brasileira de Estudos Urbanos e Regionais

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2022, Volume 24 elocation e202219pt

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Parte-se do entendimento de que processos de articulação territorial, com vistas à prospecção do futuro desejado territorialmente, exigem práticas de governança colaborativa, horizontal e democrática, envolvendo agentes estatais e representações dos setores sociais, produtivo-empresarial e universitários. Ambientes de alta complexidade, aliados à transformação digital contemporânea, alteraram significativamente a agenda dos territórios, permitindo questionar as competências e capacidades dos atores territoriais para atuar em processos de articulação territorial. Isso ratifica a visão de que essa complexidade sistêmica seja assimilada por intermédio de um hibridismo metodológico, multirreferencial, que contemple processos de coprodução e pesquisa-ação. O objetivo deste artigo é gerar aportes teórico-metodológicos para abordar os desafios postos ao Estado e à sociedade na construção de capacidades para as práticas de governança territorial. O texto está estruturado na forma de um ensaio teórico, referenciado na produção acadêmica latino-americana sobre o tema.

Abstract This research assumes that processes of territorial articulation, in order to achieve the desired territorial future, require democratic, horizontal, and collaborative practices of territorial governance, involving state agents and representatives from the social, productive-business and academic sectors. Highly complex environments together with the current digital transformation have significantly changed the agenda across territories. These issues have led to questioning the competencies and capabilities of the territorial actors with regard to their performances in the processes of territorial articulation. Against this backdrop, the notion has been ratified that this systemic complexity is assimilated through a methodological, multi-referential hybridism, which includes processes of co-production and action research. The objective of this article is to produce theoretical and methodological contributions in order to address the challenges posed to the state and society in building capabilities for practices of territorial governance. The text has been structured as a theoretical essay referenced in Latin American academic production regarding the subject.

https://doi.org/10.22296/2317-1529.rbeur.202219pt

Excess adiposity and low physical fitness hamper Supine-to-Stand test performance among sedentary adolescents
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Tadiotto, Maiara C.

; Duncan, Michael

; Mota, Jorge

; Moraes-Junior, Frederico B.

; Corazza, Patricia R.P.

; Czoczuk, Matheus

; Menezes-Junior, Francisco J. de

; Tozo, Tatiana A.A.

; Coelho-e-Silva, Manuel J.

; Rodacki, André L.F.

; Leite, Neiva

Jornal de Pediatria

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dec 2021, Volume 97 N. 6 Pages 658 - 664

Abstract: En | Text: En | PDF: En

Abstract Objective: The aim of this study was to analyze the relationship between body adiposity and physical fitness with performance in the Supine-to-Stand test (STS-test) in sedentary adolescents. Methods: Sixty-two adolescents, of both sexes, between 10 and 16 years old, participated in the study. Body mass (BM), height, waist circumference (WC), fat mass (FM), fat-free mass (FFM), right and left handgrip strength (HGS-right, HGS-left), abdominal resistance (ABDO), flexibility (FLEX), and cardiorespiratory fitness (VO2peak) were measured. Body mass index (BMI), z-score BMI (BMI-z), tri-ponderal mass index (TMI) and waist-to-height ratio (WHtR) were calculated. The STS-test was applied to evaluate the STS-MC by the movement patterns in the execution of the test. The STS-time in seconds (s) was categorized into terciles: fast (FG < 2.0 s), intermediate (IG = 2.0-2.6 s) and slow (SG > 2.6 s). One-way ANOVA, Chi-square, Spearman’s correlation coefficient as well as non-parametric tests were used, with significance p 0.05. Results: The SG presented higher BMI, BMI-z, TMI, WHtR, FM, %FM, as well as lower averages for %FFM, HGS-right, HGS-left, FLEX, ABDO, VO2peak, VO2peak relative to BM (VO2peakBM) in relation to GF. The BMI, BMI-z, TMI, WC, WHtR and FM showed moderate and direct correlations with STS-time and inverse with STS-MC (p < 0.01). HGS-right, HGS-left, ABDO, and VO2peakBM showed moderate and an inverse correlation with STS-time (p < 0.05). The VO2peakBM was moderate and with direct correlations to STS-MC (p < 0.01). Conclusion: It is concluded that excess fat and low physical fitness hamper STS-test performance. Therefore, the STS-test can be used for screening students to assess MC.

https://doi.org/10.1016/j.jped.2021.01.007 1 downloads

A cidadania europeia na escola: complementando o currículo
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Piedade, Filipe

; Ribeiro, Norberto

; Malafaia, Carla

; Loff, Manuel

; Menezes, Isabel

; Neves, Tiago

Educação e Pesquisa

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2021, Volume 47 elocation e230371

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo O projeto de criação de uma cidadania europeia comum pede aos sistemas educativos dos vários estados-membros da União Europeia (UE) que contribuam para a formação de cidadãos europeus críticos/as e ativos/as relativamente ao objetivo de prossecução e aperfeiçoamento do projeto europeu. Em Portugal, estudos anteriores ao nível do ensino secundário identificaram sérias lacunas, tanto nos currículos como nos manuais escolares de algumas disciplinas, nas abordagens pedagógicas sugeridas para o processo de ensino/aprendizagem acerca dessa dimensão europeia. Neste artigo, procurou perceber-se que tipos de atividades extra e co-curriculares as escolas têm vindo a dinamizar no sentido de complementar essas lacunas. Para tal, foram entrevistados/as 16 professores/as de 4 escolas do ensino secundário português. Os seus discursos permitiram identificar vários tipos de atividades extra e co-curriculares que têm vindo a ser dinamizadas pelas escolas para aumentarem o conhecimento e o nível de reflexividade dos/as estudantes sobre a UE. A análise desses relatos permitiu ainda identificar potencialidades e limitações inerentes ao desenvolvimento destas atividades, assim como produzir algumas recomendações para que as escolas possam dar uma contribuição mais eficaz ao projeto de consolidação de uma cidadania europeia ativa e crítica.

Abstract The project of creating a common European citizenship requires that the educational systems from the different member-states of the European Union (EU) contribute to the education of European citizens that are critical and active regarding the objective of continuing and perfecting the European project. In Portugal, previous studies of upper secondary education have shown serious shortcomings, both in the curricula and the textbooks of several subjects, in the pedagogical approaches suggested for the process of teaching/learning about this European dimension. In this article, we have tried to find out which kind of extra and co-curricular activities the schools have been organizing to fill the previously mentioned shortcomings. To that end, we have interviewed 16 teachers from 4 different schools of the Portuguese upper secondary educational system. Their accounts have allowed us to identify several kinds of extra and co-curricular activities that have been implemented by their schools in order to increase their students´ level of knowledge and reflexiveness regarding the EU. The analysis of these accounts has also allowed us to identify both the potential and limitations involved in developing these activities and to make some general recommendations towards improving the conditions for the schools to give a more efficient contribution to the objective of consolidating a active and critical European citizenship.

https://doi.org/10.1590/s1678-4634202147230371 140 downloads

Wastewater reuse in irrigation: short-term effect on soil carbon and nitrogen stocks in Brazilian semi-arid region
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Corrêa, Marcus Metri

; Cavalcanti, Marília Costa

; Primo, Dário Costa

; Rolim Neto, Fernando Cartaxo

; Martins, Jean Manuel

; Menezes, Rômulo Simões Cezar

; Antonino, Antonio Celso Dantas

; Mendes, Isaque de Souza

; Medeiros, Lívia Regina dos Santos

Revista Ambiente & Água

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2021, Volume 16 N. 1 elocation e2623

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo O principal processo natural que se contrapõe ao Efeito Estufa é chamado de sequestro de carbono, um fenômeno que essencialmente busca estabelecer um equilíbrio dinâmico entre a emissão dos gases do efeito estufa (GEE) a partir da imobilização de seus elementos, especialmente do C e N. O presente trabalho teve como objetivo principal avaliar os estoques de C e N em solo da região semiárida do Brasil submetido a irrigação com água residual tratada de esgoto doméstico. Para isso, o estoque de carbono e nitrogênio do solo soram comparados para quatro diferentes usos: caatinga nativa aberta (ONC); irrigação com água residual tratada (TSEI); irrigação com água superficial (SWI); e agricultura de sequeiro (TRA). A hipótese levantada na pesquisa foi de que o reuso de efluentes tratados na agricultura, além de ser uma alternativa que pode mitigar a problemática de escassez hídrica da região semiárida, também é capaz de influenciar a capacidade de estocar C e N no solo devido a sua carga orgânica. Os resultados indicaram que entre os diferentes usos de solos avaliados, os estoques de C e N no solo foi maior na ONC diminuindo com o uso do solo para a agricultura. O maior acúmulo de C e N na caatinga deve-se a presença de serrapilheira, não sendo detectado, no presente estudo, influência da irrigação com efluente de esgoto tratado. Conclui-se que o aporte de resíduos de vegetação na superfície do solo vem a ser o fator de maior contribuição para a estocagem de carbono e nitrogênio nos solos estudados.

Abstract The main process that opposes the Greenhouse Effect is called “carbon sequestration”, a phenomenon that essentially seeks to establish a dynamic balance between greenhouse gas (GHG) emissions from the immobilization of its elements, especially C and N. This work evaluated the stocks of carbon and nitrogen in soils of the Brazilian semi-arid submitted to irrigation with treated wastewater from domestic sewage. For this purpose, the carbon and nitrogen stocks in the soil of the semi-arid region of Brazil were compared for four different uses: Open Native Caatinga (ONC); Treated Wastewater Effluent Irrigation (TSEI); Surface Water Irrigation (SWI); and Traditional Rainfed Agriculture (TRA). The hypothesis considered in this research was that the application of treated effluents in agriculture, besides being an alternative that can mitigate the problem of water scarcity of the semiarid region, is also capable of influencing the storage capacity of C and N in the soil, due to its organic load. The results indicate that among the different land uses evaluated, soil C and N stocks were highest in ONC, and decreased with the agricultural land use. The greatest accumulation of C and N in Caatinga is due to the presence of forest litter, and the influence of irrigation with treated sewage effluent was not detected in the present study. It can be concluded that the contribution of vegetation residues to the soil surface is the main factor contributing to C and N storage.

https://doi.org/10.4136/ambi-agua.2623 624 downloads

The pattern of high plant diversity of Neotropical inselbergs: highlighting endemic, threatened and unique species
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Pinto-Junior, Herval Vieira

; Villa, Pedro Manuel

; Pereira, Miriam Cristina Alvarez

; Menezes, Luis Fernando Tavares de

Acta Botanica Brasilica

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dec 2020, Volume 34 N. 4 Pages 645 - 661

Abstract: En | Text: En | PDF: En

ABSTRACT Understanding how multiple drivers shape plant community diversity across environmental gradients is one of the most important issues in plant ecology and biodiversity conservation. We aimed to analyse plant community structure and diversity in four inselbergs in Espírito Santo State, Brazil. We evaluated species diversity, floristic composition and similarity, phytosociological structure, occurrence, and conservation status of rupicolous flora in the inselberg communities. We used field expeditions and plant inventory data from 370 sampling units. We estimated floristic similarity and compared diversity indexes among inselbergs. We observed marked differences in community structure and diversity among inselbergs, where the southern region had the highest number of taxa and higher values of diversity indices. There were also notable differences in floristic composition and phytosociological structure, with a decrease in similarity as geographical distance increased. This finding demonstrated the existence of differences in the patterns of dominance and vegetation cover along the latitudinal gradient, as well as differences in endemic, threatened, and exclusive species, and represents a first step toward establishing criteria for biodiversity conservation for inselbergs in Espírito Santo State.

https://doi.org/10.1590/0102-33062020abb0129 379 downloads

Identification of clusters of asthma control: A preliminary analysis of the Inspirers studies
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Jácome, Cristina

; Amaral, Rita

; Almeida, Rute

; Pereira, Ana Margarida

; Couto, Mariana

; Araújo, Luís

; Alves-Correia, Magna

; Pereira, Mariana

; Ferreira-Magalhães, Manuel

; Loureiro, Cláudia Chaves

; Catarata, Maria Joana

; Santos, Lília Maia

; Cabral, Sara

; Pereira, João

; Ramos, Bárbara

; Lopes, Cristina

; Mendes, Ana

; Lopes, Anabela

; Rodrigues, José Carlos Cidrais

; Oliveira, Georgeta

; Aguiar, Ana Paula

; Afonso, Ivete

; Carvalho, Joana

; Arrobas, Ana Maria

; Costa, José

; Valério, Margarida

; Pereira, Marta

; Almeida, Teresa

; Dias, Joana

; Bom, Ana Todo

; Azevedo, João

; Ribeiro, Carmelita

; Alves, Marta

; Pinto, Paula Leiria

; Neuparth, Nuno

; Neves, Ana Castro

; Palhinha, Ana

; Marques, João Gaspar

; Martins, Pedro

; Trincão, David Pina

; Todo-Bom, Filipa

; Santos, Maria Alvarenga

; Branco, Joana

; Costa, Alberto

; Neto, Armandina Silva

; Santalha, Marta

; Lozoya, Carlos

; Santos, Natacha

; Silva, Diana

; Vasconcelos, Maria João

; Barata, Luís Taborda

; Teixeira, Maria Fernanda

; Pinto, Diana

; Alves, Rodrigo Rodrigues

; Moreira, Ana Sofia

; Pinto, Cláudia Sofia

; Silva, Pedro Morais

; Alves, Carlos

; Câmara, Raquel

; Coelho, Didina

; Bordalo, Diana

; Carvalho, Fernanda

; Fernandes, Ricardo

; Ferreira, Rosário

; Oliveira, José Ferraz de

; Menezes, Fernando

; Gomes, Ricardo

; Calix, Maria José

; Marques, Ana

; Cardoso, João

; Emiliano, Madalena

; Gerardo, Rita

; Nunes, Carlos

; Ferreira, José Alberto

; Lopes, Inês

; Alves, Adelaide

; Fonseca, João Almeida

Revista Portuguesa de Imunoalergologia

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dec 2020, Volume 28 N. 4 Pages 231 - 240

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Objetivos: Identificar clusters de controlo da asma baseados no Teste de Controlo da Asma e Rinite Alérgica (CARAT) e comparar as características dos doentes nos diferentes clusters. Métodos: Adultos e adolescentes (≥13 anos) com asma persistente foram recrutados em 29 centros no contexto de 2 estudos observacionais do projeto INSPIRERS. Foram recolhidos dados relativos a características demográficas e clínicas, adesão ao inalador, crenças sobre a medicação, sintomas de ansiedade e depressão, qualidade de vida e controlo da asma (CARAT, >24 bom controlo). Foi efetuada uma análise hierárquica de clusters usando a pontuação total do CARAT (CARAT-T).Resultados: Foram analisados 410 doentes (68% adultos), com uma idade mediana (percentil 25-percentil 75) de 28 (16-46) anos. Foram identificados três clusters [média CARAT-T(min-max)]: cluster 1 [27(24-30)], cluster 2 [19(14-23)] e cluster 3 [10(2-13)]. Os doentes no cluster 1 (34%) apresentavam melhor controlo da asma, melhor qualidade de vida, maior adesão aos inaladores e usavam um único inalador. Os doentes nos clusters 2 (50%) e 3 (16%) tinham a asma não controlada, menor adesão aos inaladores, mais sintomas de ansiedade e depressão e mais de metade reportavam pelo menos uma exacerbação no último ano. Adicionalmente, os doentes no cluster 3 eram predominantemente mulheres, tinham mais consultas médicas não agendadas, apresentavam mais sintomas de ansiedade, percebiam uma maior necessidade dos inaladores, mas também uma maior preocupação associada ao seu uso. Não se verificaram diferenças na idade, índice de massa corporal, função pulmonar, hábitos tabágicos, hospitalizações ou tempo de seguimento pelo médico especialista. Conclusões: Um método não supervisionado baseado no CARAT-T, identificou 3 clusters de doentes com diferentes características clínicas. O cluster com melhor controlo apresenta um ponto de corte semelhante ao estabelecido no estudo de validação do CARAT. Este estudo sugere ainda a existência de um ponto de corte adicional para distinguir doença mais grave. Mais investigação é necessária para validar os clusters identificados

Aims: To identify distinct asthma control clusters based on Control of Allergic Rhinitis and Asthma Test (CARAT) and to compare patients’ characteristics among these clusters. Methods: Adults and adolescents (≥13 years) with persistent asthma were recruited at 29 Portuguese hospital outpatient clinics, in the context of two observational studies of the INSPIRERS project. Demographic and clinical characteristics, adherence to inhaled medication, beliefs about inhaled medication, anxiety and depression, quality of life, and asthma control (CARAT, >24 good control) were collected. Hierarchical cluster analysis was performed using CARAT total score (CARAT-T). Results: 410 patients (68% adults), with a median (percentile 25-percentile 75) age of 28 (16-46) years, were analysed. Three clusters were identified [mean CARAT-T (min-max)]: cluster 1 [27(24-30)], cluster 2 [19(14-23)] and cluster 3 [10(2-13)]. Patients in cluster 1 (34%) were characterised by better asthma control, better quality of life, higher inhaler adherence and use of a single inhaler. Patients in clusters 2 (50%) and 3 (16%) had uncontrolled asthma, lower inhaler adherence, more symptoms of anxiety and depression and more than half had at least one exacerbation in the previous year. Furthermore, patients in cluster 3 were predominantly female, had more unscheduled medical visits and more anxiety symptoms, perceived a higher necessity of their prescribed inhalers but also higher levels of concern about taking these inhalers. There were no differences in age, body mass index, lung function, smoking status, hospital admissions or specialist physician follow-up time among the three clusters. Conclusion: An unsupervised method based on CARAT-T, identified 3 clusters of patients with distinct, clinically meaningful characteristics. The cluster with better asthma control had a cut-off similar to the established in the validation study of CARAT and an additional cut-off seems to distinguish more severe disease. Further research is necessary to validate the asthma control clusters identified.

https://doi.org/10.32932/rpia.2020.12.046 633 downloads

10.

HLA-B*14 allele predicts HIV-1 mother-to-child-transmission, in Salvador, Brazil
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Angulo, Juan Manuel Cubillos

; Cuesta, Taryn Ariadna Castro

; Menezes, Eliane Pereira

; Pedroso, Celia

; Brites, Carlos

Brazilian Journal of Infectious Diseases

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mar 2019, Volume 23 N. 2 Pages 71 - 78

Abstract: En | Text: En | PDF: En

ABSTRACT Background: Class I human leukocyte antigens, especially the molecules encoded at the B locus (HLA-B), are associated with AIDS progression risk. Different groups of HLA-B alleles have been associated to a protective effect or increasing susceptibility to HIV infection and are expressed from the earliest stages of gestation. Objective: The aim of this study was to evaluate which variants of HLA-B are associated with the risk of HIV vertical transmission in infected pregnant women and in their offspring, in a referral center in Salvador Bahia. Methods: We performed HLA-B genotyping in 52 HIV-infected mothers and their children exposed to HIV-1 during pregnancy (N = 65) in Salvador, Brazil. We compared the HLA-B alleles frequency in mothers, uninfected and infected children, according to the use of antiretroviral prophylaxis. Results: Absence of antiretroviral antenatal and postnatal prophylaxis was significantly associated with vertical transmission of HIV-1 (p = <0.01, and p = <0.01 respectively). Frequency of HLA-B*14 (29.2%, p = 0.002), HLA-B*18 (16.7%, p = 0.04) or HLA-B*14:1 (20.8%, p = 0.01) alleles subgroups were significantly higher in HIV-1 infected children and persisted (HLA-B*14, p = 0.04) even after adjusting for use of antiretroviral prophylaxis. No significant difference in expression of HLA-B alleles was observed among mothers who transmitted the virus compared to those who did not. Conclusions: Expression of HLA-B*14 allele in children exposed to HIV-1 is predictive of vertical transmission and reinforces the important role of genetics in mother-to-child transmission.

https://doi.org/10.1016/j.bjid.2019.04.009 484 downloads

11.

A SYSTEMATIC REVIEW ON THE INFLUENCE OF HLA-B POLYMORPHISMS ON HIV-1 MOTHER-TO-CHILD-TRANSMISSION
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Angulo, Juan Manuel Cubillos

; Cuesta, Taryn Ariadna Castro

; Menezes, Eliane Pereira

; Pedroso, Celia

; Brites, Carlos

Brazilian Journal of Infectious Diseases

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jan 2019, Volume 23 N. 1 Pages 53 - 59

Abstract: En | Text: En | PDF: En

ABSTRACT Background: Mother-to-child-transmission (MTCT) is the main route of HIV-1 infection in children. Genetic studies suggest HLA-B alleles play an important role on HIV-1 transmission, progression, and control of HIV-1 infection. Objective: To evaluate which polymorphisms of HLA-B are involved in HIV-1 MTCT. Methods: Two independent reviewers performed a systematic review on search engines PubMed, Europe PMC, Cochrane, Scientific Electronic Library Online (SciELO), and Literatura Latino-americana e do Caribe em Ciências da Saúde (Lilacs), using the following key terms: "HIV infection", "HIV newborn", "HLA polymorphisms", "HLA-B", and "Mother to child transmission". All studies focusing on evaluation of HIV-1 MTCT, HIV infection evolution, and molecular analyses of HLA-B in children were selected. Results: Nine studies fulfilled the inclusion criteria. Sixteen HLA-B alleles groups were associated with HIV-1 infection; seven of them (43.8%) were related to slow disease progression or reduced risk of MTCT, while six (37.5%) alleles groups were linked to a faster progression of HIV infection in children and to increased risk of MTCT. The available evidence suggest that HLA-B*57 group allele is associated with slow disease progression, while HLA-B*35 group allele is associated to increased risk of MTCT and rapid disease progression in infected children. The role of HLA-B*18, B*58 and B*44 are still controversial because they were associated to both, protection against MTCT, and to higher HIV replicative capacity, in different studies. Conclusion: HLA-B*57 group allele can be protective against MTCT while HLA-B*35 groups alleles are consistently associated with HIV-1 MTCT.

https://doi.org/10.1016/j.bjid.2018.12.002 596 downloads

12.

Axial compressive strength of human vertebrae trabecular bones classified as normal, osteopenic and osteoporotic by quantitative ultrasonometry of calcaneus
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Cesar, Reinaldo

; Leivas, Tomaz Puga

; Pereira, Cesar Augusto Martins

; Boffa, Ricardo Simionato

; Guarniero, Roberto

; Reiff, Rodrigo Bezerra de Menezes

; Mandeli Netto, Antônio

; Fortulan, Carlos Alberto

; Rollo, João Manuel Domingos de Almeida

Research on Biomedical Engineering

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jun 2017, Volume 33 N. 2 Pages 91 - 96

Abstract: En | Text: En | PDF: En

Abstract Introduction Biomechanical assessment of trabecular bone microarchitecture contributes to the evaluation of fractures risk associated with osteoporosis and plays a crucial role in planning preventive strategies. One of the most widely clinical technics used for osteoporosis diagnosis by health professionals is bone dual-energy X-ray absorptiometry (DEXA). However, doubts about its accuracy motivate the introduction of congruent technical analysis such as calcaneal ultrasonometry (Quantitative Ultrasonometry - QUS). Methods Correlations between Bone Quality Index (BQI), determined by calcaneal ultrasonometry of thirty (30) individuals classified as normal, osteopenic and osteoporotic, and elastic modulus (E) and ultimate compressive strength (UCS) from axial compression tests of ninety (90) proof bodies from human vertebrae trabecular bone, which were extracted from cadavers in the twelfth thoracic region (T12), first and fourth lumbar (L1 and L4). Results Analysis of variance (ANOVA) showed significant differences for E (p = 0.001), for UCS (p = 0.0001) and BQI. Spearman’s rank correlation coefficient (rho) between BQI and E (r = 0.499) and BQI and UCS (r = 0.508) were moderate. Discussion Calcaneal ultrasonometry technique allowed a moderate estimate of bone mechanical strength and fracture risk associated with osteoporosis in human vertebrae.

https://doi.org/10.1590/2446-4740.04116 1166 downloads

13.

PRODUÇÃO DE SUBJETIVIDADES NO TRABALHO EM UMA UNIDADE DE TERAPIA INTENSIVA PEDIÁTRICA
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Peixoto, Tereza Cristina

; Passos, Izabel Christina Friche

; Brito, Maria José Menezes

; Ó, Jorge Manuel Nunes Ramos do

Psicologia & Sociedade

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2017, Volume 29 elocation e161193

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

Resumo Objetivou-se analisar a micropolítica das relações interprofissionais em uma unidade de terapia intensiva pediátrica. Trata-se de um estudo com abordagem qualitativa, de cunho cartográfico, com observações da dinâmica das relações entre os sujeitos, entrevistas com 14 profissionais, no período de junho a agosto de 2014. As relações interprofissionais são constituídas em um território híbrido formado pela interseção dos saberes biomédicos, práticas de trabalho intervencionistas com aparelhos tecnológicos, reguladas por normas, protocolos e pelo lidar com crianças e seus pais. O afeto despertado nos profissionais frente à espontaneidade e sofrimento de crianças desestabiliza o plano normativo e científico do trabalho em prol da estabilização orgânica das crianças, desencadeando novos agenciamentos dos profissionais, ora flexibilizando as normas, ora intensificando comportamentos controladores e perfeccionistas. Aponta-se a importância da potencialização dos agenciamentos inventivos dos profissionais e criação de dispositivos para ações coletivas e saberes que promovam a associação da clínica da vida junto à da sobrevida.

Abstract This study aimed to analyze the micropolitics of interbranch relations in a pediatric intensive care unit. It is a study with a qualitative approach, of cartographic character. Observations of the dynamics of relationships between the professionals and interviews with fourteen professionals from June to August 2014 were carried out. Interbranch relations are constituted in a hybrid territory formed by the intersection of biomedical knowledge, interventionist work practices with technological gadgets, which are regulated by standards, protocols, and by dealing with children and their parents. The affection aroused in professional front of spontaneity and children’s suffering destabilizes the regulatory and scientific plan of work towards the organic stabilization of children, unleashing new agencies of the professionals, sometimes loosening the rules, sometimes intensifying behaviors controllers and perfectionists. This paper also points out the importance of empowering the professionals’ inventive agencies, and creating mechanisms for collective action and knowledge towards promoting the clinical association of life with the survival.

Resumen Este estudio tuve como objetivo analizar las relaciones interprofesionales y micropoliticas en una unidad de cuidados intensivos pediátricos. Se trata de un estudio con un enfoque cualitativo, de carácter cartográfico, con observación de la dinámica de las relaciones entre los profesionales y entrevistas con 14 profesionales llevadas a cabo de junio a agosto de 2014. Las relaciones interprofesionales se constituyen en un territorio híbrido formado por la intersección del conocimiento biomédico, prácticas intervencionistas con dispositivos tecnológicos, regulados por normas, protocolos y por el tratamiento a los niños y sus padres. El afecto despertado en los profesionales frente a la espontaneidad y el sufrimiento de los niños desestabiliza el plan normativo y científico de lo trabajo em favor de la estabilización orgánica de los niños, desencadenando nuevos agenciamientos de los profesionales, ora flexibilizando las normas, ora intensificando comportamientos controladores y perfeccionistas. Se señala la importancia de la potenciación de los agenciamientos inventivos de los profesionales y creación de dispositivos para acciones colectivas y saberes que promuevan la asociación de la clínica de la vida a de la supervivencia.

https://doi.org/10.1590/1807-0310/2017v29161193 1964 downloads

14.

Recent updates and perspectives on approaches for the development of vaccines against visceral leishmaniasis
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Duarte, Mariana Costa

; Lage, Daniela Pagliara

; Martins, Vívian Tamietti

; Chávez-Fumagalli, Miguel Angel

; Roatt, Bruno Mendes

; Menezes-Souza, Daniel

; Goulart, Luiz Ricardo

; Soto, Manuel

; Tavares, Carlos Alberto Pereira

; Coelho, Eduardo Antonio Ferraz

Revista da Sociedade Brasileira de Medicina Tropical

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aug 2016, Volume 49 N. 4 Pages 398 - 407

Abstract: En | Text: En | PDF: En

Abstract: Visceral leishmaniasis (VL) is one of the most important tropical diseases worldwide. Although chemotherapy has been widely used to treat this disease, problems related to the development of parasite resistance and side effects associated with the compounds used have been noted. Hence, alternative approaches for VL control are desirable. Some methods, such as vector control and culling of infected dogs, are insufficiently effective, with the latter not ethically recommended. The development of vaccines to prevent VL is a feasible and desirable measure for disease control; for example, some vaccines designed to protect dogs against VL have recently been brought to market. These vaccines are based on the combination of parasite fractions or recombinant proteins with adjuvants that are able to induce cellular immune responses; however, their partial efficacy and the absence of a vaccine to protect against human leishmaniasis underline the need for characterization of new vaccine candidates. This review presents recent advances in control measures for VL based on vaccine development, describing extensively studied antigens, as well as new antigenic proteins recently identified using immuno-proteomic techniques.

https://doi.org/10.1590/0037-8682-0120-2016 14239 downloads

15.

Cartilage reconstruction using self-anchoring implant with functional gradient
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Laurenti, Karen Cristina

; Haach, Lourdes Cristina de Albuquerque

; Santos Jr., Arnaldo Rodrigues dos

; Rollo, João Manuel Domingos de Almeida

; Reiff, Rodrigo Bezerra de Menezes

; Gaspar, Ana Maria Minarelli

; Purquerio, Benedito de Moraes

; Fortulan, Carlos Alberto

Materials Research

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jun 2014, Volume 17 N. 3 Pages 638 - 649

Abstract: En | Text: En | PDF: En

This study presents an innovative and original biomaterial designed to substitute for articular cartilage and mimic its mechanical behavior, including elastic cushioning and the characteristics of fiber-reinforced gel. The material was composed of polyurethane and bioglass microfiber 45S5. It was designed to present a tribological surface to the cartilage of the tibial plateau, and to convert over a functional gradient to an osteointegrable region for self-anchorage to the subchondral bone. The biomaterial samples showed no toxicity and promoted cell spreading. Subsequent in vivo studies in rabbits demonstrated the formation of a rigid structure similar to bone trabeculae in the distal region of the tribological surface of the implant. The tribological surface of the proximal region showed a fibrocartilaginous tissue with highly vascularized chondrocytes, thus validating the proposed concept for the design of the implant incorporating a functional gradient and auto-stability.

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