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1.
Atingimento das Metas de Colesterol LDL em Pacientes com Histórico de Infarto Agudo do Miocárdio: Estudo Transversal do Mundo Real Miocárdio
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Gomes, Daniel A.
; Paiva, Mariana Sousa
; Freitas, Pedro
; Albuquerque, Francisco
; Lima, Maria Rita
; Santos, Rita Reis
; Presume, João
; Trabulo, Marisa
; Aguiar, Carlos
; Ferreira, Jorge
; Ferreira, António M.
; Mendes, Miguel
.
Abstract Background: The European Society of Cardiology guidelines recommend an LDL-cholesterol (LDL-C) < 55 mg/dL for patients with established cardiovascular disease. While the Friedewald equation to estimate LDL-C is still widely used, the newer Martin-Hopkins equation has shown greater accuracy. Objectives: We aimed to assess: A) the proportion of patients reaching LDL-C goal and the therapies used in a tertiary center; B) the impact of using the Martin-Hopkins method instead of Friedewald’s on the proportion of controlled patients. Methods: A single-center cross-sectional study including consecutive post-myocardial infarction patients followed by 20 cardiologists in a tertiary hospital. Data was collected retrospectively from clinical appointments that took place after April 2022. For each patient, the LDL-C levels and attainment of goals were estimated from an ambulatory lipid profile using both Friedewald and Martin-Hopkins equations. A two-tailed p-value of < 0.05 was considered statistically significant for all tests. Results: Overall, 400 patients were included (aged 67 ± 13 years, 77% male). Using Friedewald’s equation, the median LDL-C under therapy was 64 (50-81) mg/dL, and 31% had LDL-C within goals. High-intensity statins were used in 64% of patients, 37% were on ezetimibe, and 0.5% were under PCSK9 inhibitors. Combination therapy of high-intensity statin + ezetimibe was used in 102 patients (26%). Applying the Martin-Hopkins method would reclassify a total of 31 patients (7.8%). Among those deemed controlled by Friedewald’s equation, 27 (21.6%) would have a Martin-Hopkins’ LDL-C above goals. Conclusions: Less than one-third of post-myocardial infarction patients had LDL-C within the goal. Applying the Martin-Hopkins equation would reclassify one-fifth of presumably controlled patients into the non-controlled group. Background LDLcholesterol LDL cholesterol LDLC C (LDL-C 5 mgdL mg dL disease MartinHopkins Martin Hopkins accuracy Objectives assess center B Friedewalds s Methods singlecenter single crosssectional cross sectional postmyocardial post myocardial 2 hospital 2022 patient equations twotailed two tailed pvalue p value 005 0 05 0.0 tests Results Overall 40 aged 6 1 years 77 male. male . male) 5081 50 81 (50-81 Highintensity High intensity 37 0.5 PCSK inhibitors highintensity high 10 26%. 26 26% (26%) 3 7.8%. 78 7.8% 7 8 (7.8%) 21.6% 216 21 (21.6% Conclusions onethird one third onefifth fifth noncontrolled non group 202 00 0. 4 508 (50-8 (26% 7.8 (7.8% 21.6 (21.6 (50- (26 7. (7.8 21. (21. (50 (2 (7. (21 (5 ( (7
Resumo Fundamento: As diretrizes da Sociedade Europeia de Cardiologia recomendam um nível de colesterol LDL (LDL-C) < 55 mg/dL para pacientes com doença cardiovascular estabelecida. Embora a fórmula de Friedewald ainda seja amplamente utilizada para estimar o LDL-C, a fórmula mais recente de Martin-Hopkins mostrou maior precisão. Objetivos: Nosso objetivo foi avaliar: A) a proporção de pacientes que atingiram a meta de LDL-C e as terapias utilizadas em um centro terciário; B) o impacto da utilização do método de Martin-Hopkins em vez do método de Friedewald na proporção de pacientes controlados. Métodos: Estudo transversal monocêntrico, incluindo pacientes consecutivos pós-infarto do miocárdio, acompanhados por 20 cardiologistas, em um hospital terciário. Os dados foram coletados retrospectivamente de consultas clínicas realizadas após abril de 2022. Para cada paciente, os níveis de LDL-C e o atingimento das metas foram estimados a partir de um perfil lipídico ambulatorial, utilizando as fórmulas de Friedewald e Martin-Hopkins. Um valor-p bicaudal < 0,05 foi considerado estatisticamente significativo para todos os testes. Resultados: Foram incluídos 400 pacientes (com 67 ± 13 anos, 77% do sexo masculino). Utilizando a fórmula de Friedewald, a mediana de LDL-C sob terapia foi de 64 (50-81) mg/dL, e 31% tinham LDL-C dentro da meta. Estatinas de alta intensidade foram usadas em 64% dos pacientes, 37% estavam em uso de ezetimiba e 0,5% estavam em uso de inibidores de PCSK9. A terapia combinada de estatina de alta intensidade + ezetimiba foi utilizada em 102 pacientes (26%). A aplicação do método de Martin-Hopkins reclassificaria um total de 31 pacientes (7,8%). Entre aqueles considerados controlados pela fórmula de Friedewald, 27 (21,6%) teriam LDL-C estimado por Martin-Hopkins acima da meta. Conclusões: Menos de um terço dos pacientes pós-infarto do miocárdio apresentaram LDL-C dentro da meta. A aplicação da fórmula de Martin-Hopkins reclassificaria um quinto dos pacientes presumivelmente controlados no grupo de pacientes não controlados. Fundamento LDLC C (LDL-C 5 mgdL mg dL estabelecida LDLC, C, MartinHopkins Martin Hopkins precisão Objetivos avaliar terciário B Métodos monocêntrico pósinfarto pós infarto 2 cardiologistas 2022 paciente ambulatorial MartinHopkins. Hopkins. valorp valor p 005 0 05 0,0 testes Resultados 40 6 1 anos 77 masculino. masculino . masculino) 5081 50 81 (50-81 37 0,5 PCSK9 PCSK 10 26%. 26 26% (26%) 3 7,8%. 78 7,8% 7 8 (7,8%) 21,6% 216 21 (21,6% Conclusões 202 00 0, 4 508 (50-8 (26% 7,8 (7,8% 21,6 (21,6 (50- (26 7, (7,8 21, (21, (50 (2 (7, (21 (5 ( (7
2.
Patentometric analysis of the technological development of biotechnology for health in higher education institutions in Rio Grande do Sul
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MENDES, CÁSSIA REGINA A.
; PAPPEN, EMELIN
; BAETA, ADELAIDE MARIA C.
; DOMINGUES, WILLIAM B.
; DELLAGOSTIN, EDUARDO N.
; CAMPOS, VINICIUS F.
; TIMMERS, LUÍS FERNANDO S.M.
; GOETTERT, MÁRCIA INES
; HENRIQUES, JOÃO ANTONIO P.
.
Abstract Biotechnology offers solutions and opportunities to meet various societal demands, thereby contributing to significant scientific advancements. This study aimed to characterize the technological development of biotechnology in the healthcare sector in the state of Rio Grande do Sul, Brazil, from 2016 to 2022 by analyzing patents filed by and granted to public and private Higher Education institutions. For data collection, a quantitative exploratory approach was employed using statistical methods and a patent analysis of institutions in the patent database of the Brazilian National Institute of Industrial Property (INPI), focusing on patents related to the healthcare field. Data were collected in October, November, and December. A total of 580 patent records were collected from the INPI, belonging to Sections A and C of the International Patent Classification (IPC) related to educational institutions. Furthermore, this study highlighted that higher education institutions have a higher number of patents in the healthcare field. These results provide an understanding of the strategic areas for technological development in biotechnology in Rio Grande do Sul, Brazil. demands advancements Sul Brazil 201 202 collection INPI , (INPI) field October November December 58 IPC (IPC Furthermore 20 (INPI 5 2
3.
Influence of soil properties on 14C-Saflufenacil behavior: Sorption and mobility study 14CSaflufenacil CSaflufenacil 14C Saflufenacil C behavior
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Oliveira, Fernando S. de
; Takeshita, Vanessa
; Mendes, Kassio F.
; Tornisielo, Valdemar Luiz
; Teófilo, Taliane Maria da S.
; Fernandes, Bruno Caio C.
; Lins, Hamurábi A.
; Silva, Daniel V.
.
Abstract: Background: Knowing the relationships between the soil's physical-chemical properties and herbicide behavior in the soil allows establishing strategies for the efficient control of weeds with less environmental risk. Objective: It carried this study to investigate the role of physical-chemical properties of Brazilian soils in the sorption-desorption and mobility of the herbicide saflufenacil. Methods: We used nine soils from different regions of Brazil in the study of sorption-desorption and mobility of 14C-saflufenacil. The herbicide sorption-desorption estimate was performed using the batch equilibrium method and mobility using soil thin-layer chromatography. Principal component analysis (PCA) and clustering were performed to evaluate the impact of soil properties on the sorption-desorption behavior of saflufenacil. Results: The results indicated that saflufenacil was weakly sorbed in different types of tropical soils, and the sorption process is reversible, with its mobility varied from mobile (Rf = 0.70) to very mobile (Rf = 0.99) in the different soils and indicates that the herbicide has leaching potential in these types of soils. The sorption-desorption capacity and mobility of saflufenacil depend mainly on pH, CEC, clay, and OC content, and therefore it is vital to analyze them to predict the impacts of herbicide application on the environment. The PCA is an essential tool that helps to clarify how the effects of soil properties influence herbicide behavior. Conclusions: The OC content in Brazilian soils has a direct role in saflufenacil sorption and desorption. BR3 soil (soil with highest organic carbon; OC = 2,1%) exhibits greater sorption (Kd = 1,85 L kg−1), value 5.5 times greater than the BR1 (soil with lower sorption; with OC = 0,6%). Therefore, the application of saflufenacil to tropical soils, especially those with low levels of CO (< 1%), may result in a greater potential risk of contamination of surface and groundwater in neighbouring agricultural and non-agricultural areas, particularly those with intensive use and ineffectiveness of saflufenacil. Future investigations could focus on integrating modeling approaches that incorporate soil variability to predict saflufenacil behavior accurately in diverse soil types, aiding in decision-making for sustainable herbicide use. Abstract Background s physicalchemical physical chemical Objective sorptiondesorption desorption Methods 14Csaflufenacil. 14Csaflufenacil Csaflufenacil 14C C 14C-saflufenacil thinlayer thin layer chromatography (PCA Results reversible Rf 0.70 070 0 70 0.99 099 99 pH CEC clay environment Conclusions BR carbon 2,1% 21 2 1 Kd 185 85 1,8 kg−1, kg1 kg kg−1 , kg−1) 55 5 5. 0,6%. 06 0,6% . 6 0,6%) Therefore < ( 1%, 1% 1%) nonagricultural non areas decisionmaking decision making 0.7 07 7 0.9 09 9 2,1 18 8 1, kg− 0,6 0. 2, 0,
4.
Catálogo Taxonômico da Fauna do Brasil: Setting the baseline knowledge on the animal diversity in Brazil Brasil
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Boeger, Walter A.
; Valim, Michel P.
; Zaher, Hussam
; Rafael, José A.
; Forzza, Rafaela C.
; Percequillo, Alexandre R.
; Serejo, Cristiana S.
; Garraffoni, André R.S.
; Santos, Adalberto J.
; Slipinski, Adam
; Linzmeier, Adelita M.
; Calor, Adolfo R.
; Garda, Adrian A.
; Kury, Adriano B.
; Fernandes, Agatha C.S.
; Agudo-Padrón, Aisur I.
; Akama, Alberto
; Silva Neto, Alberto M. da
; Burbano, Alejandro L.
; Menezes, Aleksandra
; Pereira-Colavite, Alessandre
; Anichtchenko, Alexander
; Lees, Alexander C.
; Bezerra, Alexandra M.R.
; Domahovski, Alexandre C.
; Pimenta, Alexandre D.
; Aleixo, Alexandre L.P.
; Marceniuk, Alexandre P.
; Paula, Alexandre S. de
; Somavilla, Alexandre
; Specht, Alexandre
; Camargo, Alexssandro
; Newton, Alfred F.
; Silva, Aline A.S. da
; Santos, Aline B. dos
; Tassi, Aline D.
; Aragão, Allan C.
; Santos, Allan P.M.
; Migotto, Alvaro E.
; Mendes, Amanda C.
; Cunha, Amanda
; Chagas Júnior, Amazonas
; Sousa, Ana A.T. de
; Pavan, Ana C.
; Almeida, Ana C.S.
; Peronti, Ana L.B.G.
; Henriques-Oliveira, Ana L.
; Prudente, Ana L.
; Tourinho, Ana L.
; Pes, Ana M.O.
; Carmignotto, Ana P.
; Wengrat, Ana P.G. da Silva
; Dornellas, Ana P.S.
; Molin, Anamaria Dal
; Puker, Anderson
; Morandini, André C.
; Ferreira, André da S.
; Martins, André L.
; Esteves, André M.
; Fernandes, André S.
; Roza, André S.
; Köhler, Andreas
; Paladini, Andressa
; Andrade, Andrey J. de
; Pinto, Ângelo P.
; Salles, Anna C. de A.
; Gondim, Anne I.
; Amaral, Antonia C.Z.
; Rondón, Antonio A.A.
; Brescovit, Antonio
; Lofego, Antônio C.
; Marques, Antonio C.
; Macedo, Antonio
; Andriolo, Artur
; Henriques, Augusto L.
; Ferreira Júnior, Augusto L.
; Lima, Aurino F. de
; Barros, Ávyla R. de A.
; Brito, Ayrton do R.
; Romera, Bárbara L.V.
; Vasconcelos, Beatriz M.C. de
; Frable, Benjamin W.
; Santos, Bernardo F.
; Ferraz, Bernardo R.
; Rosa, Brunno B.
; Sampaio, Brunno H.L.
; Bellini, Bruno C.
; Clarkson, Bruno
; Oliveira, Bruno G. de
; Corrêa, Caio C.D.
; Martins, Caleb C.
; Castro-Guedes, Camila F. de
; Souto, Camilla
; Bicho, Carla de L.
; Cunha, Carlo M.
; Barboza, Carlos A. de M.
; Lucena, Carlos A.S. de
; Barreto, Carlos
; Santana, Carlos D.C.M. de
; Agne, Carlos E.Q.
; Mielke, Carlos G.C.
; Caetano, Carlos H.S.
; Flechtmann, Carlos H.W.
; Lamas, Carlos J.E.
; Rocha, Carlos
; Mascarenhas, Carolina S.
; Margaría, Cecilia B.
; Waichert, Cecilia
; Digiani, Celina
; Haddad, Célio F.B.
; Azevedo, Celso O.
; Benetti, Cesar J.
; Santos, Charles M.D. dos
; Bartlett, Charles R.
; Bonvicino, Cibele
; Ribeiro-Costa, Cibele S.
; Santos, Cinthya S.G.
; Justino, Cíntia E.L.
; Canedo, Clarissa
; Bonecker, Claudia C.
; Santos, Cláudia P.
; Carvalho, Claudio J.B. de
; Gonçalves, Clayton C.
; Galvão, Cleber
; Costa, Cleide
; Oliveira, Cléo D.C. de
; Schwertner, Cristiano F.
; Andrade, Cristiano L.
; Pereira, Cristiano M.
; Sampaio, Cristiano
; Dias, Cristina de O.
; Lucena, Daercio A. de A.
; Manfio, Daiara
; Amorim, Dalton de S.
; Queiroz, Dalva L. de
; Queiroz, Dalva L. de
; Colpani, Daniara
; Abbate, Daniel
; Aquino, Daniel A.
; Burckhardt, Daniel
; Cavallari, Daniel C.
; Prado, Daniel de C. Schelesky
; Praciano, Daniel L.
; Basílio, Daniel S.
; Bená, Daniela de C.
; Toledo, Daniela G.P. de
; Takiya, Daniela M.
; Fernandes, Daniell R.R.
; Ament, Danilo C.
; Cordeiro, Danilo P.
; Silva, Darliane E.
; Pollock, Darren A.
; Muniz, David B.
; Gibson, David I.
; Nogueira, David S.
; Marques, Dayse W.A.
; Lucatelli, Débora
; Garcia, Deivys M.A.
; Baêta, Délio
; Ferreira, Denise N.M.
; Rueda-Ramírez, Diana
; Fachin, Diego A.
; Souza, Diego de S.
; Rodrigues, Diego F.
; Pádua, Diego G. de
; Barbosa, Diego N.
; Dolibaina, Diego R.
; Amaral, Diogo C.
; Chandler, Donald S.
; Maccagnan, Douglas H.B.
; Caron, Edilson
; Carvalho, Edrielly
; Adriano, Edson A.
; Abreu Júnior, Edson F. de
; Pereira, Edson H.L.
; Viegas, Eduarda F.G.
; Carneiro, Eduardo
; Colley, Eduardo
; Eizirik, Eduardo
; Santos, Eduardo F. dos
; Shimbori, Eduardo M.
; Suárez-Morales, Eduardo
; Arruda, Eliane P. de
; Chiquito, Elisandra A.
; Lima, Élison F.B.
; Castro, Elizeu B. de
; Orlandin, Elton
; Nascimento, Elynton A. do
; Razzolini, Emanuel
; Gama, Emanuel R.R.
; Araujo, Enilma M. de
; Nishiyama, Eric Y.
; Spiessberger, Erich L.
; Santos, Érika C.L. dos
; Contreras, Eugenia F.
; Galati, Eunice A.B.
; Oliveira Junior, Evaldo C. de
; Gallardo, Fabiana
; Hernandes, Fabio A.
; Lansac-Tôha, Fábio A.
; Pitombo, Fabio B.
; Dario, Fabio Di
; Santos, Fábio L. dos
; Mauro, Fabio
; Nascimento, Fabio O. do
; Olmos, Fabio
; Amaral, Fabio R.
; Schunck, Fabio
; Godoi, Fábio S. P. de
; Machado, Fabrizio M.
; Barbo, Fausto E.
; Agrain, Federico A.
; Ribeiro, Felipe B.
; Moreira, Felipe F.F.
; Barbosa, Felipe F.
; Silva, Fenanda S.
; Cavalcanti, Fernanda F.
; Straube, Fernando C.
; Carbayo, Fernando
; Carvalho Filho, Fernando
; Zanella, Fernando C.V.
; Jacinavicius, Fernando de C.
; Farache, Fernando H.A.
; Leivas, Fernando
; Dias, Fernando M.S.
; Mantellato, Fernando
; Vaz-de-Mello, Fernando Z.
; Gudin, Filipe M.
; Albuquerque, Flávio
; Molina, Flavio B.
; Passos, Flávio D.
; Shockley, Floyd W.
; Pinheiro, Francielly F.
; Mello, Francisco de A.G. de
; Nascimento, Francisco E. de L.
; Franco, Francisco L.
; Oliveira, Francisco L. de
; Melo, Francisco T. de V.
; Quijano, Freddy R.B.
; Salles, Frederico F.
; Biffi, Gabriel
; Queiroz, Gabriel C.
; Bizarro, Gabriel L.
; Hrycyna, Gabriela
; Leviski, Gabriela
; Powell, Gareth S.
; Santos, Geane B. dos
; Morse, Geoffrey E.
; Brown, George
; Mattox, George M.T.
; Zimbrão, Geraldo
; Carvalho, Gervásio S.
; Miranda, Gil F.G.
; Moraes, Gilberto J. de
; Lourido, Gilcélia M.
; Neves, Gilmar P.
; Moreira, Gilson R.P.
; Montingelli, Giovanna G.
; Maurício, Giovanni N.
; Marconato, Gláucia
; Lopez, Guilherme E.L.
; Silva, Guilherme L. da
; Muricy, Guilherme
; Brito, Guilherme R.R.
; Garbino, Guilherme S.T.
; Flores, Gustavo E.
; Graciolli, Gustavo
; Libardi, Gustavo S.
; Proctor, Heather C.
; Gil-Santana, Helcio R.
; Varella, Henrique R.
; Escalona, Hermes E.
; Schmitz, Hermes J.
; Rodrigues, Higor D.D.
; Galvão Filho, Hilton de C.
; Quintino, Hingrid Y.S.
; Pinto, Hudson A.
; Rainho, Hugo L.
; Miyahira, Igor C.
; Gonçalves, Igor de S.
; Martins, Inês X.
; Cardoso, Irene A.
; Oliveira, Ismael B. de
; Franz, Ismael
; Fernandes, Itanna O.
; Golfetti, Ivan F.
; S. Campos-Filho, Ivanklin
; Oliveira, Ivo de S.
; Delabie, Jacques H.C.
; Oliveira, Jader de
; Prando, Jadila S.
; Patton, James L.
; Bitencourt, Jamille de A.
; Silva, Janaina M.
; Santos, Jandir C.
; Arruda, Janine O.
; Valderrama, Jefferson S.
; Dalapicolla, Jeronymo
; Oliveira, Jéssica P.
; Hájek, Jiri
; Morselli, João P.
; Narita, João P.
; Martin, João P.I.
; Grazia, Jocélia
; McHugh, Joe
; Cherem, Jorge J.
; Farias Júnior, José A.S.
; Fernandes, Jose A.M.
; Pacheco, José F.
; Birindelli, José L.O.
; Rezende, José M.
; Avendaño, Jose M.
; Duarte, José M. Barbanti
; Ribeiro, José R. Inácio
; Mermudes, José R.M.
; Pujol-Luz, José R.
; Santos, Josenilson R. dos
; Câmara, Josenir T.
; Teixeira, Joyce A.
; Prado, Joyce R. do
; Botero, Juan P.
; Almeida, Julia C.
; Kohler, Julia
; Gonçalves, Julia P.
; Beneti, Julia S.
; Donahue, Julian P.
; Alvim, Juliana
; Almeida, Juliana C.
; Segadilha, Juliana L.
; Wingert, Juliana M.
; Barbosa, Julianna F.
; Ferrer, Juliano
; Santos, Juliano F. dos
; Kuabara, Kamila M.D.
; Nascimento, Karine B.
; Schoeninger, Karine
; Campião, Karla M.
; Soares, Karla
; Zilch, Kássia
; Barão, Kim R.
; Teixeira, Larissa
; Sousa, Laura D. do N.M. de
; Dumas, Leandro L.
; Vieira, Leandro M.
; Azevedo, Leonardo H.G.
; Carvalho, Leonardo S.
; Souza, Leonardo S. de
; Rocha, Leonardo S.G.
; Bernardi, Leopoldo F.O.
; Vieira, Letícia M.
; Johann, Liana
; Salvatierra, Lidianne
; Oliveira, Livia de M.
; Loureiro, Lourdes M.A. El-moor
; Barreto, Luana B.
; Barros, Luana M.
; Lecci, Lucas
; Camargos, Lucas M. de
; Lima, Lucas R.C.
; Almeida, Lucia M.
; Martins, Luciana R.
; Marinoni, Luciane
; Moura, Luciano de A.
; Lima, Luciano
; Naka, Luciano N.
; Miranda, Lucília S.
; Salik, Lucy M.
; Bezerra, Luis E.A.
; Silveira, Luis F.
; Campos, Luiz A.
; Castro, Luiz A.S. de
; Pinho, Luiz C.
; Silveira, Luiz F.L.
; Iniesta, Luiz F.M.
; Tencatt, Luiz F.C.
; Simone, Luiz R.L.
; Malabarba, Luiz R.
; Cruz, Luiza S. da
; Sekerka, Lukas
; Barros, Lurdiana D.
; Santos, Luziany Q.
; Skoracki, Maciej
; Correia, Maira A.
; Uchoa, Manoel A.
; Andrade, Manuella F.G.
; Hermes, Marcel G.
; Miranda, Marcel S.
; Araújo, Marcel S. de
; Monné, Marcela L.
; Labruna, Marcelo B.
; Santis, Marcelo D. de
; Duarte, Marcelo
; Knoff, Marcelo
; Nogueira, Marcelo
; Britto, Marcelo R. de
; Melo, Marcelo R.S. de
; Carvalho, Marcelo R. de
; Tavares, Marcelo T.
; Kitahara, Marcelo V.
; Justo, Marcia C.N.
; Botelho, Marcia J.C.
; Couri, Márcia S.
; Borges-Martins, Márcio
; Felix, Márcio
; Oliveira, Marcio L. de
; Bologna, Marco A.
; Gottschalk, Marco S.
; Tavares, Marcos D.S.
; Lhano, Marcos G.
; Bevilaqua, Marcus
; Santos, Marcus T.T.
; Domingues, Marcus V.
; Sallum, Maria A.M.
; Digiani, María C.
; Santarém, Maria C.A.
; Nascimento, Maria C. do
; Becerril, María de los A.M.
; Santos, Maria E.A. dos
; Passos, Maria I. da S. dos
; Felippe-Bauer, Maria L.
; Cherman, Mariana A.
; Terossi, Mariana
; Bartz, Marie L.C.
; Barbosa, Marina F. de C.
; Loeb, Marina V.
; Cohn-Haft, Mario
; Cupello, Mario
; Martins, Marlúcia B.
; Christofersen, Martin L.
; Bento, Matheus
; Rocha, Matheus dos S.
; Martins, Maurício L.
; Segura, Melissa O.
; Cardenas, Melissa Q.
; Duarte, Mércia E.
; Ivie, Michael A.
; Mincarone, Michael M.
; Borges, Michela
; Monné, Miguel A.
; Casagrande, Mirna M.
; Fernandez, Monica A.
; Piovesan, Mônica
; Menezes, Naércio A.
; Benaim, Natalia P.
; Reategui, Natália S.
; Pedro, Natan C.
; Pecly, Nathalia H.
; Ferreira Júnior, Nelson
; Silva Júnior, Nelson J. da
; Perioto, Nelson W.
; Hamada, Neusa
; Degallier, Nicolas
; Chao, Ning L.
; Ferla, Noeli J.
; Mielke, Olaf H.H.
; Evangelista, Olivia
; Shibatta, Oscar A.
; Oliveira, Otto M.P.
; Albornoz, Pablo C.L.
; Dellapé, Pablo M.
; Gonçalves, Pablo R.
; Shimabukuro, Paloma H.F.
; Grossi, Paschoal
; Rodrigues, Patrícia E. da S.
; Lima, Patricia O.V.
; Velazco, Paul
; Santos, Paula B. dos
; Araújo, Paula B.
; Silva, Paula K.R.
; Riccardi, Paula R.
; Garcia, Paulo C. de A.
; Passos, Paulo G.H.
; Corgosinho, Paulo H.C.
; Lucinda, Paulo
; Costa, Paulo M.S.
; Alves, Paulo P.
; Roth, Paulo R. de O.
; Coelho, Paulo R.S.
; Duarte, Paulo R.M.
; Carvalho, Pedro F. de
; Gnaspini, Pedro
; Souza-Dias, Pedro G.B.
; Linardi, Pedro M.
; Bartholomay, Pedro R.
; Demite, Peterson R.
; Bulirsch, Petr
; Boll, Piter K.
; Pereira, Rachel M.M.
; Silva, Rafael A.P.F.
; Moura, Rafael B. de
; Boldrini, Rafael
; Silva, Rafaela A. da
; Falaschi, Rafaela L.
; Cordeiro, Ralf T.S.
; Mello, Ramon J.C.L.
; Singer, Randal A.
; Querino, Ranyse B.
; Heleodoro, Raphael A.
; Castilho, Raphael de C.
; Constantino, Reginaldo
; Guedes, Reinaldo C.
; Carrenho, Renan
; Gomes, Renata S.
; Gregorin, Renato
; Machado, Renato J.P.
; Bérnils, Renato S.
; Capellari, Renato S.
; Silva, Ricardo B.
; Kawada, Ricardo
; Dias, Ricardo M.
; Siewert, Ricardo
; Brugnera, Ricaro
; Leschen, Richard A.B.
; Constantin, Robert
; Robbins, Robert
; Pinto, Roberta R.
; Reis, Roberto E. dos
; Ramos, Robson T. da C.
; Cavichioli, Rodney R.
; Barros, Rodolfo C. de
; Caires, Rodrigo A.
; Salvador, Rodrigo B.
; Marques, Rodrigo C.
; Araújo, Rodrigo C.
; Araujo, Rodrigo de O.
; Dios, Rodrigo de V.P.
; Johnsson, Rodrigo
; Feitosa, Rodrigo M.
; Hutchings, Roger W.
; Lara, Rogéria I.R.
; Rossi, Rogério V.
; Gerstmeier, Roland
; Ochoa, Ronald
; Hutchings, Rosa S.G.
; Ale-Rocha, Rosaly
; Rocha, Rosana M. da
; Tidon, Rosana
; Brito, Rosangela
; Pellens, Roseli
; Santos, Sabrina R. dos
; Santos, Sandra D. dos
; Paiva, Sandra V.
; Santos, Sandro
; Oliveira, Sarah S. de
; Costa, Sávio C.
; Gardner, Scott L.
; Leal, Sebastián A. Muñoz
; Aloquio, Sergio
; Bonecker, Sergio L.C.
; Bueno, Sergio L. de S.
; Almeida, Sérgio M. de
; Stampar, Sérgio N.
; Andena, Sérgio R.
; Posso, Sergio R.
; Lima, Sheila P.
; Gadelha, Sian de S.
; Thiengo, Silvana C.
; Cohen, Simone C.
; Brandão, Simone N.
; Rosa, Simone P.
; Ribeiro, Síria L.B.
; Letana, Sócrates D.
; Santos, Sonia B. dos
; Andrade, Sonia C.S.
; Dávila, Stephane
; Vaz, Stéphanie
; Peck, Stewart B.
; Christo, Susete W.
; Cunha, Suzan B.Z.
; Gomes, Suzete R.
; Duarte, Tácio
; Madeira-Ott, Taís
; Marques, Taísa
; Roell, Talita
; Lima, Tarcilla C. de
; Sepulveda, Tatiana A.
; Maria, Tatiana F.
; Ruschel, Tatiana P.
; Rodrigues, Thaiana
; Marinho, Thais A.
; Almeida, Thaís M. de
; Miranda, Thaís P.
; Freitas, Thales R.O.
; Pereira, Thalles P.L.
; Zacca, Thamara
; Pacheco, Thaynara L.
; Martins, Thiago F.
; Alvarenga, Thiago M.
; Carvalho, Thiago R. de
; Polizei, Thiago T.S.
; McElrath, Thomas C.
; Henry, Thomas
; Pikart, Tiago G.
; Porto, Tiago J.
; Krolow, Tiago K.
; Carvalho, Tiago P.
; Lotufo, Tito M. da C.
; Caramaschi, Ulisses
; Pinheiro, Ulisses dos S.
; Pardiñas, Ulyses F.J.
; Maia, Valéria C.
; Tavares, Valeria
; Costa, Valmir A.
; Amaral, Vanessa S. do
; Silva, Vera C.
; Wolff, Vera R. dos S.
; Slobodian, Verônica
; Silva, Vinícius B. da
; Espíndola, Vinicius C.
; Costa-Silva, Vinicius da
; Bertaco, Vinicius de A.
; Padula, Vinícius
; Ferreira, Vinicius S.
; Silva, Vitor C.P. da
; Piacentini, Vítor de Q.
; Sandoval-Gómez, Vivian E.
; Trevine, Vivian
; Sousa, Viviane R.
; Sant’Anna, Vivianne B. de
; Mathis, Wayne N.
; Souza, Wesley de O.
; Colombo, Wesley D.
; Tomaszewska, Wioletta
; Wosiacki, Wolmar B.
; Ovando, Ximena M.C.
; Leite, Yuri L.R.
.
ABSTRACT The limited temporal completeness and taxonomic accuracy of species lists, made available in a traditional manner in scientific publications, has always represented a problem. These lists are invariably limited to a few taxonomic groups and do not represent up-to-date knowledge of all species and classifications. In this context, the Brazilian megadiverse fauna is no exception, and the Catálogo Taxonômico da Fauna do Brasil (CTFB) (http://fauna.jbrj.gov.br/), made public in 2015, represents a database on biodiversity anchored on a list of valid and expertly recognized scientific names of animals in Brazil. The CTFB is updated in near real time by a team of more than 800 specialists. By January 1, 2024, the CTFB compiled 133,691 nominal species, with 125,138 that were considered valid. Most of the valid species were arthropods (82.3%, with more than 102,000 species) and chordates (7.69%, with over 11,000 species). These taxa were followed by a cluster composed of Mollusca (3,567 species), Platyhelminthes (2,292 species), Annelida (1,833 species), and Nematoda (1,447 species). All remaining groups had less than 1,000 species reported in Brazil, with Cnidaria (831 species), Porifera (628 species), Rotifera (606 species), and Bryozoa (520 species) representing those with more than 500 species. Analysis of the CTFB database can facilitate and direct efforts towards the discovery of new species in Brazil, but it is also fundamental in providing the best available list of valid nominal species to users, including those in science, health, conservation efforts, and any initiative involving animals. The importance of the CTFB is evidenced by the elevated number of citations in the scientific literature in diverse areas of biology, law, anthropology, education, forensic science, and veterinary science, among others. publications problem uptodate up date classifications context exception (CTFB http//fauna.jbrj.gov.br/, httpfaunajbrjgovbr http //fauna.jbrj.gov.br/ , jbrj gov br (http://fauna.jbrj.gov.br/) 2015 Brazil 80 specialists 1 2024 133691 133 691 133,69 125138 125 138 125,13 82.3%, 823 82 3 (82.3% 102000 102 000 102,00 7.69%, 769 7 69 (7.69% 11000 11 11,00 . 3,567 3567 567 (3,56 2,292 2292 2 292 (2,29 1,833 1833 833 (1,83 1,447 1447 447 (1,44 1000 1,00 831 (83 628 (62 606 (60 520 (52 50 users science health biology law anthropology education others http//fauna.jbrj.gov.br/ faunajbrjgovbr //fauna.jbrj.gov.br (http://fauna.jbrj.gov.br/ 201 8 202 13369 13 133,6 12513 12 125,1 82.3% (82.3 10200 10 00 102,0 7.69% 76 6 (7.69 1100 11,0 3,56 356 56 (3,5 2,29 229 29 (2,2 1,83 183 83 (1,8 1,44 144 44 (1,4 100 1,0 (8 62 (6 60 52 (5 5 http//fauna.jbrj.gov.br (http://fauna.jbrj.gov.br 20 1336 133, 1251 125, 82.3 (82. 1020 0 102, 7.69 (7.6 110 11, 3,5 35 (3, 2,2 22 (2, 1,8 18 (1, 1,4 14 4 ( 82. (82 7.6 (7. 3, (3 2, (2 (1 7. (7
5.
Preliminary evaluation of the toxicological, antioxidant and antitumor activities promoted by the compounds 2,4-dihydroxy-benzylidene-thiosemicarbazones an in silico, in vitro and in vivo study toxicological 2,4dihydroxybenzylidenethiosemicarbazones 24dihydroxybenzylidenethiosemicarbazones dihydroxybenzylidenethiosemicarbazones 2,4 dihydroxy benzylidene thiosemicarbazones 2 4 silico 4dihydroxybenzylidenethiosemicarbazones 24 2,
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LEAL, MAYSE MANUELE F.V.
; SILVA, MARIA FERNANDA DA
; MARQUES, DIEGO SANTA CLARA
; MENDES, RAUDINEY FRANKILIN V.
; XIMENES, RAFAEL M.
; MACHADO, DIJANAH C.
; SILVA JÚNIOR, JANILSON JOSÉ DA
; RODRIGUES, CLÁUDIO GABRIEL
; FILHO, IRANILDO JOSÉ DA CRUZ
; LIMA, MARIA DO CARMO A. DE
.
Abstract Thiosemicarbazones are promising classes of compounds with antitumor activity. For this study, six 2,4-dihydroxy-benzylidene-thiosemicarbazones compounds were synthesized. These compounds were submitted to different assays in silico, in vitro and in vivo to evaluate the toxicological, antioxidant and antitumor effects. The in silico results were evaluated by the SwissADME and pkCSM platforms and showed that all compounds had good oral bioavailability profiles. The in vitro and in vivo toxicity assays showed that the compounds showed low cytotoxicity against different normal cells and did not promote hemolytic effects. The single dose acute toxicity test (2000 mg/kg) showed that none of the compounds were toxic to mice. In in vitro antioxidant activity assays, the compounds showed moderate to low activity, with PB17 standing out for the ABTS radical capture assay. The in vivo antioxidant activity highlighted the compounds 1, 6 and 8 that promoted a significant increase in the concentration of liver antioxidant enzymes. Finally, all compounds showed promising antitumor activity against different cell lines, especially MCF-7 and DU145 lines, in addition, they inhibited the growth of sarcoma 180 at concentrations lower than 50 mg/kg. These results showed that the evaluated compounds can be considered as potential antitumor agents. study 2,4dihydroxybenzylidenethiosemicarbazones 24dihydroxybenzylidenethiosemicarbazones dihydroxybenzylidenethiosemicarbazones 2,4 dihydroxy benzylidene thiosemicarbazones 2 4 synthesized toxicological effects profiles 2000 (200 mg/kg mgkg mg kg mice PB PB1 assay 1 enzymes Finally lines MCF7 MCF 7 MCF- DU DU14 addition 18 5 agents 4dihydroxybenzylidenethiosemicarbazones 24 2, 200 (20 DU1 20 (2 (
6.
Characterization by near infrared spectroscopy of seeds and oils of Amaranthus spp. as a function of cropping systems spp
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Mavaieie, Denilson Paulo da Rosa
; Souza, Douglas Correa de
; Ramalho, Fernanda Maria Guedes
; Mavaieie, Valquíria de Fatima Ferreira
; Resende, Luciane Vilela
; Guimarães, Renato Mendes
.
ABSTRACT Species of the Amaranthus genus are very versatile and have potential for the application in the development of commercial products. The near infrared spectroscopy (NIR) is an efficient tool that can help in the quality control of products, quickly and non-destructive to the sample. The goal of this study was to carry out the distinction of seed and oils of different Amaranthus species using the near infrared spectroscopy. Three species were used: A. viridis L., A. hybridus L. e Amaranthus sp. (commercial). The spectra acquired from the sample using the near infrared spectroscopy were submitted to the partial least squares discriminant analysis (PLS-DA) and to the principal component analysis (PCA). Through PCA, it was possible to differentiate the Amaranthus species both for seeds and oils. Through PLS-DA, it was possible to predict the classes of the species with high degree of correct classification, with 96.67% of correct classifications for seeds and 98.89% for oil. Thus, with the use of the near infrared spectroscopy associated with the multivariate statistical analysis, it is possible to classify the different Amaranthus species, especially when using the oil. products NIR (NIR nondestructive non destructive used A L sp commercial. . (commercial) PLSDA PLS DA (PLS-DA PCA. PCA (PCA) PLSDA, DA, PLS-DA classification 9667 96 67 96.67 9889 98 89 98.89 oil Thus (commercial (PCA 966 9 6 96.6 988 8 98.8 96. 98.
7.
Periodontal diseases and tooth wear in sheep flocks in the State of Goiás, Brazil Goiás
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Martins, Andressa S.
; Silva, Tamires A.
; Athayde, Flávia R.F.
; Saraiva, Júlia R.
; Mendes, Juliana G.
; Cardoso, Maria Vitória S.
; Dutra, Iveraldo S.
; Borsanelli, Ana Carolina
.
RESUMO: As afecções dentárias e periodontais constituem uma preocupação sanitária de grande importância em rebanhos ovinos, uma vez que afetam a saúde e o bem-estar dos animais, e representam uma das principais causas para o abate prematuro. No Brasil, estudos sobre a ocorrência dessas afecções em ovinos são escassos. Assim, o presente estudo teve como objetivo avaliar a prevalência de doenças periodontais e desgaste dentário em rebanhos ovinos no estado de Goiás. Para isso, realizou-se o exame clínico bucal em 325 ovinos em sete propriedades rurais de seis municípios do estado. As lesões periodontais, caracterizadas por recessão gengival em, pelo menos, um dente incisivo, foram observadas em 48,3% (157/325) dos ovinos, enquanto nos mastigatórios ocorreu em 13,2% (43/325) dos ovinos avaliados. O desgaste dentário em dentes mastigatórios foi identificado em 69,2% (255/325) dos ovinos e 10,7% (35/325) dos ovinos apresentaram desgaste dentário em dentes incisivos. Ovinos com idade superior a 36 meses tiveram um aumento na frequência do desgaste dentário. Dos 325 ovinos examinados, 171 (52,62%) apresentaram sinais de sangramento à sondagem, compatíveis com o quadro de gengivite, sendo que 69 (40,36%) apresentaram idade superior a 36 meses. Dos 325 ovinos avaliados, 38 (11,69%) apresentaram gengivite em todos os dentes, dos quais 21 (55,26%) apresentaram idade superior a 36 meses. Pela análise de regressão logística, foi possível observar que a idade mostrou associação com a ocorrência de gengivite. Alterações menos frequentes como a bolsa periodontal e a perda de, pelo menos, um elemento dentário também foram observadas em 4,9% (16/325) e 17,8% (58/325) dos ovinos, respectivamente. Os resultados do presente estudo indicam que a presença doenças periodontais e desgaste dentário é uma ocorrência comum nos rebanhos avaliados. Portanto, enfatiza-se a necessidade de incluir a saúde bucal dos ovinos na rotina da propriedade como uma medida preventiva essencial para melhorar a qualidade de vida e o bem-estar dos animais, bem como os índices zootécnicos. RESUMO bemestar estar animais prematuro Brasil escassos Assim Goiás isso realizouse realizou se 32 incisivo 483 48 3 48,3 157/325 157325 157 (157/325 132 13 2 13,2 43/325 43325 43 (43/325 avaliados 692 69,2 255/325 255325 255 (255/325 107 10 7 10,7 35/325 35325 35 (35/325 incisivos examinados 17 52,62% 5262 52 62 (52,62% sondagem 6 40,36% 4036 40 (40,36% 11,69% 1169 11 (11,69% 55,26% 5526 55 26 (55,26% logística 49 4 9 4,9 16/325 16325 16 (16/325 178 8 17,8 58/325 58325 58 (58/325 respectivamente Portanto enfatizase enfatiza zootécnicos 48, 157/32 15732 15 (157/32 1 13, 43/32 4332 (43/32 69, 255/32 25532 25 (255/32 10, 35/32 3532 (35/32 52,62 526 5 (52,62 40,36 403 (40,36 11,69 116 (11,69 55,26 552 (55,26 4, 16/32 1632 (16/32 17, 58/32 5832 (58/32 157/3 1573 (157/3 43/3 433 (43/3 255/3 2553 (255/3 35/3 353 (35/3 52,6 (52,6 40,3 (40,3 11,6 (11,6 55,2 (55,2 16/3 163 (16/3 58/3 583 (58/3 157/ (157/ 43/ (43/ 255/ (255/ 35/ (35/ 52, (52, 40, (40, 11, (11, 55, (55, 16/ (16/ 58/ (58/ (157 (43 (255 (35 (52 (40 (11 (55 (16 (58 (15 (4 (25 (3 (5 (1 ( (2
ABSTRACT: Dental and periodontal affections consist of health concerns of great importance in sheep flocks, as they affect the health and welfare of animals and represent one of the main causes of premature slaughter. Studies on the occurrence of these conditions in sheep are scarce in Brazil. The present study aimed to evaluate the prevalence of periodontal diseases and tooth wear in sheep flocks in the State of Goiás. For this, a clinical oral examination was conducted on 325 sheep from seven farms in six municipalities of the State. Periodontal lesions, characterized by gingival recession in at least one incisor tooth, were observed in 48.3% (157/325) of the sheep, while in cheek teeth it occurred in 13.2% (43/325) of the evaluated sheep. Dental wear on cheek teeth was identified in 69.2% (255/325) of the sheep, and 10.7% (35/325) of the ovines showed dental wear on incisor teeth. Sheep older than 36 months had an increase in the frequency of tooth wear. A total of 171 (52.62%) out of the 325 examined sheep had signs of bleeding on probing, which is compatible with gingivitis, and 69 (40.36%) were older than 36 months. Thirty-eight (11.69%) out of the 325 evaluated ovines had gingivitis in all teeth, among which 21 (55.26%) were older than 36 months. Logistic regression analysis allowed the observation that age was associated with the occurrence of gingivitis. Less frequent changes such as periodontal pockets and loss of at least one tooth were also observed in 4.9% (16/325) and 17.8% (58/325) of the sheep, respectively. It indicates that the presence of periodontal diseases and tooth wear is a common occurrence in the evaluated flocks. Therefore, there is a need to include the oral health of sheep in the routine of the farm as an essential preventive measure to improve the quality of life, animal welfare, and zootechnical indices. ABSTRACT slaughter Brazil Goiás this 32 lesions 483 48 3 48.3 157/325 157325 157 (157/325 132 13 2 13.2 43/325 43325 43 (43/325 692 69.2 255/325 255325 255 (255/325 107 10 7 10.7 35/325 35325 35 (35/325 17 52.62% 5262 52 62 (52.62% probing 6 40.36% 4036 40 (40.36% Thirtyeight Thirty eight 11.69% 1169 11 (11.69% 55.26% 5526 55 26 (55.26% 49 4 9 4.9 16/325 16325 16 (16/325 178 8 17.8 58/325 58325 58 (58/325 respectively Therefore life indices 48. 157/32 15732 15 (157/32 1 13. 43/32 4332 (43/32 69. 255/32 25532 25 (255/32 10. 35/32 3532 (35/32 52.62 526 5 (52.62 40.36 403 (40.36 11.69 116 (11.69 55.26 552 (55.26 4. 16/32 1632 (16/32 17. 58/32 5832 (58/32 157/3 1573 (157/3 43/3 433 (43/3 255/3 2553 (255/3 35/3 353 (35/3 52.6 (52.6 40.3 (40.3 11.6 (11.6 55.2 (55.2 16/3 163 (16/3 58/3 583 (58/3 157/ (157/ 43/ (43/ 255/ (255/ 35/ (35/ 52. (52. 40. (40. 11. (11. 55. (55. 16/ (16/ 58/ (58/ (157 (43 (255 (35 (52 (40 (11 (55 (16 (58 (15 (4 (25 (3 (5 (1 ( (2
8.
Physicochemical and bioactive properties of Apis and stingless bee (Meliponini) honey from Brazilian Caatinga Meliponini (Meliponini
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Araújo, Filipe Gomes de
; Araújo, Nícolas Oliveira de
; Oliveira, Victor Rafael Leal de
; Leite, Ricardo Henrique de Lima
; Santos, Francisco Klebson Gomes dos
; Aroucha, Edna Maria Mendes
.
ABSTRACT. Since the composition of honey varies with the species of bee as well as flowering and geographical aspects, this study aimed to evaluate the physicochemical and bioactive properties of Apisand stingless bees’honey from the Brazilian Caatinga. Samples of different species of Apis mellifera L.Meliponini (Melipona subnitida, Frieseomellita varia, Melipona mandacaia, Plebeia sp.) and Apis mellifera L.werecollected from honey producersin the state of Rio Grande do Norte. Honey from A. mellifera and stingless bees showed physicochemical differences in some parameters, especially in moisture, free acidity, HMF, water activity, sugars and electric conductivity. There were no differences in color between honeys from A. mellifera and stingless bees. Honeys fromPlebeia sp., F. varia and A. mellifera showed higher antioxidant capacity followed by honeys fromM. mandacaia and M. subnitida. Flavonoids had little influence on the differentiation of antioxidant activities of stingless bees, while the opposite occurred with the phenolic content, where honeys with the highest levels of phenolic also showed higher antioxidant capacity. ABSTRACT aspects beeshoney Caatinga LMeliponini L Meliponini subnitida sp. sp Lwerecollected werecollected Norte A parameters moisture acidity HMF activity conductivity F fromM M content
9.
Processing Biodegradable Blends of Hemicellulose with Polyhydroxybutyrate and Poly (Lactic Acid) Lactic Acid
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Mendes, Ívia Maria Lourenço
; Fialho, Michaella Socorro Bruce
; Leão, Rosineide Miranda
; Silveira, Edgar A.
; Luz, Sandra Maria da
.
The bottleneck of hemicellulose as a bio-based material is its processability and property drawbacks (softening and hydrophilicity). Thus, mixing other biopolymers can be an alternative. This article proposes blending hemicellulose (10−50 wt%) with polyhydroxybutyrate (PHB) and poly (lactic acid) (PLA), using acetic acid and chloroform as casting solvents to improve its processability and thermal properties. The materials were thermally (TGA - thermogravimetric analysis), chemically (FTIR - Fourier transformer infrared) and morphologically (SEM - scanning electron microscopy) characterized. Finally, a multicriteria decision analysis (MCDA) evaluated the materials’ properties to identify the optimum combination (casting solvent, biopolymer and hemicelluloses proportion) for producing an optimal blend. The MCDA established that the blend of hemicellulose:PHB (10:90 wt/wt) produced with acetic acid was optimum considering melting temperature and the crystallinity criteria. Moreover, higher hemicellulose concentration in the blends decreased the MCDA success rate, indicating the worst properties. PLA blends showed a higher degradation temperature than PHB. The PHB blends produced with acetic acid demonstrated improved properties when compared to chloroform, revealing its potential as a solvent. biobased bio based softening hydrophilicity. hydrophilicity . hydrophilicity) Thus alternative 10−50 1050 10 50 (10−5 wt% wt (PHB lactic PLA, , (PLA) TGA analysis, analysis) FTIR infrared SEM microscopy characterized Finally (MCDA solvent proportion hemicellulosePHB 1090 90 (10:9 wt/wt wtwt criteria Moreover rate 10−5 105 1 5 (10− (PLA 109 9 (10: 10− (10 (1 (
10.
Deep-sea living (stained) benthic foraminifera from the continental slope and São Paulo Plateau, Santos Basin (SW Atlantic): ecological insights Deepsea Deep sea stained (stained Plateau SW Atlantic Atlantic)
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Araújo, Beatriz D.
; Yamashita, Cintia
; Santarosa, Ana C. A.
; Rocha, Amanda V.
; Vicente, Thaisa M.
; Mendes, Rafaela N. M.
; Passos, Camila C.
; Martins, Maria Virginia Alves
; Sousa, Silvia Helena M.
.
Abstract This study aimed to characterize the spatial distribution and composition of living Benthic Foraminifera (BF) and to comprehend how environmental conditions (e.g., organic matter) can affect communities of these protozoa in the northern and southern sectors of the Santos Basin (SB), in the continental slope and São Paulo Plateau. In this context, 23 stations (65 samples including replicates at each station) were collected between 400 and 2,400 m water depth. Multivariate analyses revealed that the ecological structure of the community changes mainly along the bathymetric gradients. Stations located between 400 and 700 m, both in northern and southern sectors, are characterized by the presence of indicator species of high intensity of currents, such as Globocassidulina subglobosa and Trifarina bradyi. These stations are also mainly marked by the occurrence of Epistominella exigua, a phytodetritivore species. The stations at 1,000 and 1,300 m depth, in both sectors, are characterized by high accumulation of organic matter in the sediments, which favors the development of agglutinated foraminifera species, such as those of the genus Reophax. Finally, the lower slope and the São Paulo Plateau, in both sectors, are oligotrophic regions, with pulses of labile organic carbon, probably low current velocities and the presence of Alabaminella weddellensis. The quantity and quality of food, which are closely related to hydro-sedimentary dynamics and bentho-pelagic coupling in the slope and São Paulo Plateau, are the main factors that influence the distribution of living BF assemblages in the SB. (BF e.g., eg e g (e.g. SB, SB , (SB) Plateau context 2 65 (6 station 40 2400 2,40 depth gradients 70 currents bradyi exigua 1000 1 000 1,00 1300 300 1,30 sediments Reophax Finally regions carbon weddellensis food hydrosedimentary hydro sedimentary benthopelagic bentho pelagic e.g. (e.g (SB 6 ( 4 240 2,4 7 100 00 1,0 130 30 1,3 e.g 24 2, 10 0 1, 13 3
11.
Estratégia Farmacoinvasiva em Idosos até 75 Anos ou Não Idosos: Análise de Parâmetros Bioquímicos e de Ressonância Nuclear Magnética Cardíaca 7
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Bacchin, Amanda S.
; Fonseca, Francisco A. H.
; Povoa, Rui
; Szarf, Gilberto
; Pinto, Ibraim Masciarelli
; Caixeta, Adriano Mendes
; Teixeira, Daniela
; Maugeri, Ieda Longo
; Ishimura, Mayari E.
; Coste, Maria E. R.
; Bianco, Henrique Tria
; França, Carolina N.
; Izar, Maria Cristina
.
Resumo Fundamento A estratégia farmacoinvasiva é uma alternativa na inviabilidade da intervenção coronária percutânea primária (ICP). Objetivos Este estudo teve como objetivo avaliar os efeitos da estratégia farmacoinvasiva precoce sobre o tamanho da área infartada e a fração de ejeção ventricular esquerda em pacientes idosos e não idosos. O papel dos marcadores inflamatórios também foi avaliado. Métodos Pacientes (n=223) com infarto do miocárdio com elevação do segmento ST (IAMCSST) foram prospectivamente incluídos e submetidos à trombólise medicamentosa nas primeiras seis horas, e à angiografia coronariana e à ICP, quando necessária, nas primeiras 24 horas. As amostras de sangue foram coletadas no primeiro dia (D1) e 30 dias após (D30). A ressonância magnética cardíaca foi realizada no D30. O nível de significância estatística foi estabelecido em p<0,05. Resultados Pacientes idosos e não idosos apresentaram porcentagem similares de massa infartada [13,7 (6,9-17,0) vs. 14,0 (7,3-26,0), respectivamente p=0,13)] [mediana (intervalo interquartil)]. No entanto, os pacientes idosos apresentaram maior fração de ejeção ventricular esquerda [53 (45-62) vs. 49 (39-58), p=0,025)]. As concentrações de interleucina (IL)1beta, IL-4, IL-6, e IL-10 não foram diferentes entre D1 e D30, mas pacientes idosos apresentaram níveis mais elevados de IL-18 em D1 e D30. O número absoluto de linfócitos B e T foram similares em ambos os grupos em D1 e D30, porém, pacientes idosos apresentaram uma razão neutrófilo-linfócito mais alta em D30. A análise de regressão linear multivariada dos desfechos de RMC de toda a população do estudo mostrou que os preditores independentes não foram diferentes entre pacientes idosos e não idosos. Conclusão A estratégia farmacoinvasiva em pacientes idosos foi associada a pequenas diferenças nos parâmetros inflamatórios, tamanho do infarto similar, e melhor função ventricular esquerda em comparação a pacientes não idosos ICP. ICP . (ICP) avaliado n=223 n223 n 223 (n=223 IAMCSST (IAMCSST horas necessária 2 D (D1 3 D30 (D30) p005 p 0 05 p<0,05 13,7 137 13 7 [13, 6,917,0 69170 6,9 17,0 6 9 17 (6,9-17,0 vs 140 14 14, 7,326,0, 73260 7,3 26,0 , 26 (7,3-26,0) p=0,13 p013 p=0,13) mediana intervalo interquartil. interquartil interquartil)] entanto 53 [5 4562 45 62 (45-62 4 3958, 3958 39 58 (39-58) p=0,025. p0025 p=0,025 025 p=0,025)] IL1beta, IL1beta ILbeta IL 1beta, 1beta beta (IL)1beta IL4, IL4 4, IL-4 IL6, IL6 6, IL-6 IL10 10 IL-1 IL18 18 porém neutrófilolinfócito neutrófilo linfócito similar (ICP n=22 n22 22 (n=22 (D D3 (D30 p00 p<0,0 13, 1 [13 917 6,917, 6917 69 170 17, (6,9-17, 326 7,326,0 7326 73 7, 260 26, (7,3-26,0 p=0,1 p01 interquartil) 5 [ 456 (45-6 395 (39-58 p002 p=0,02 02 p=0,025) IL- IL1 n=2 n2 (n=2 (D3 p0 p<0, [1 91 6,917 691 (6,9-17 32 7,326, 732 (7,3-26, p=0, (45- (39-5 p=0,0 n= (n= p<0 6,91 (6,9-1 7,326 (7,3-26 p=0 (45 (39- (n p< (6,9- 7,32 (7,3-2 p= (4 (39 (6,9 (7,3- ( (3 (6, (7,3 (6 (7, (7
Abstract Background Pharmacoinvasive strategy is an alternative when primary percutaneous coronary intervention (PCI) is not feasible. Objectives This study aimed to evaluate the effects of early pharmacoinvasive strategy on the infarct size and left ventricular ejection fraction in elderly and non-elderly patients. The role of inflammatory markers was also examined. Methods Patients (n=223) with ST segment elevation myocardial infarction (STEMI) were prospectively included and submitted to pharmacological thrombolysis in the first six hours, and underwent coronary angiogram and PCI when necessary, in the first 24 hours. Blood samples were collected in the first day (D1) and after 30 days (D30). Cardiac magnetic resonance imaging (cMRI) was performed at D30. Significance was set at p<0.05. Results Elderly and non-elderly patients showed similar percentage of infarcted mass (13.7 [6.9-17.0] vs. 14.0 [7.3-26.0], respectively, p=0.13) (median [interquartile range]). However, elderly patients had better left ventricular ejection fraction (53 [45-62] vs. 49 [39-58], p=0.025). Titers of interleukin (IL)1beta, IL-4, IL-6, and IL-10 did not differ between D1 and D30, but elderly patients had higher titers for IL-18 at D1 and D30. Absolute numbers of B and T lymphocytes were similar in both groups at D1 and D30, but elderly patients had higher neutrophil/lymphocyte ratio at D30. Multivariate linear regression analysis of cMRI outcomes in the whole population showed that the independent predictors were not different between elderly and non-elderly patients. Conclusion Pharmacoinvasive strategy in elderly patients was associated with small differences in inflammatory parameters, similar infarct size and better left ventricular function than non-elderly patients. (PCI feasible nonelderly non examined n=223 n223 n 223 (n=223 STEMI (STEMI hours necessary 2 D (D1 3 D30 . (D30) (cMRI p005 p 0 05 p<0.05 13.7 137 13 7 (13. 6.917.0 69170 6.9 17.0 6 9 17 [6.9-17.0 vs 140 14 14. 7.326.0, 73260 7.3 26.0 , 26 [7.3-26.0] respectively p=0.13 p013 median interquartile range. range range]) However 53 (5 4562 45 62 [45-62 4 3958, 3958 39 58 [39-58] p=0.025. p0025 p=0.025 025 p=0.025) IL1beta, IL1beta ILbeta IL 1beta, 1beta beta (IL)1beta IL4, IL4 4, IL-4 IL6, IL6 6, IL-6 IL10 10 IL-1 IL18 18 neutrophillymphocyte neutrophil lymphocyte parameters n=22 n22 22 (n=22 (D D3 (D30 p00 p<0.0 13. 1 (13 917 6.917. 6917 69 6. 170 17. [6.9-17. 326 7.326.0 7326 73 7. 260 26. [7.3-26.0 p=0.1 p01 range] 5 ( 456 [45-6 395 [39-58 p002 p=0.02 02 IL- IL1 n=2 n2 (n=2 (D3 p0 p<0. (1 91 6.917 691 [6.9-17 32 7.326. 732 [7.3-26. p=0. [45- [39-5 p=0.0 n= (n= p<0 6.91 [6.9-1 7.326 [7.3-26 p=0 [45 [39- (n p< [6.9- 7.32 [7.3-2 p= [4 [39 [6.9 [7.3- [ [3 [6. [7.3 [6 [7. [7
12.
Botanical Authentication of “Espinheira-Santa” [Monteverdia ilicifolia (Mart. ex Reissek) Biral] Samples by FTIR Spectroscopy Coupled with PCA and Photoacoustic Spectroscopy EspinheiraSanta Espinheira Santa “Espinheira-Santa Monteverdia Mart. Mart (Mart Reissek Biral
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Martins, Mylena de França
; Marcon, Marcia Viviane
; Egg, Cynthia Maria Schnekenberg
; Dias, Daniele Toniolo
; Manfron, Jane
; Nadal, Jessica Mendes
; Farago, Paulo Vitor
; Novatski, Andressa
.
Brazilian Archives of Biology and Technology
- Journal Metrics
Abstract Monteverdia ilicifolia (Mart. ex Reissek) Biral (basionym: Maytenus ilicifolia Mart. ex Reissek) (Celastraceae) is popularly known as holy thorn or “espinheira-santa” in Brazil. This herb is traditionally used for gastric and digestive problems. However, similar species are often used as adulterants. Considering the pharmacological interest and the existence of adulterants, this study was devoted to characterizing M. ilicifolia samples by Fourier-transform infrared (FTIR) spectroscopy coupled with principal component analysis (PCA) and photoacoustic spectroscopy (PAS) by using Citronella gongonha (Mart.) R. A. Howard as adulterant sample. Six commercial samples were purchased, and seven collected samples were obtained in the Campos Gerais region. The leaves were then dehydrated and converted to powder. The FTIR spectroscopic assay was carried out and consisted of ten different measurements for each sample with a time interval of seven days between them. The PCA was performed from these spectra. The characterization by FTIR demonstrated the presence of tannins and flavonoids in the studied samples. FTIR spectroscopy coupled with PCA was able to discriminate the commercial and the collected samples of M. ilicifolia using three principal components. The photoacoustic spectroscopy resulted in absorption bands centered at ~280, ~380, ~480, and ~630 nm. These bands presented a higher spectral resolution for the collected samples. The commercial samples showed broadening bands, which allowed the differentiation between these two sets of samples. FTIR spectroscopy coupled with PCA, and photoacoustic spectroscopy are alternative tools for the differentiation of M. ilicifolia samples. Mart (Mart Reissek basionym (basionym Celastraceae (Celastraceae espinheirasanta espinheira santa “espinheira-santa Brazil problems However adulterants M Fouriertransform Fourier transform (FTIR (PCA PAS (PAS R A purchased region powder them spectra components 280 ~280 380 ~380 480 ~480 630 ~63 nm 28 ~28 38 ~38 48 ~48 63 ~6 2 ~2 3 ~3 4 ~4 6 ~
13.
Herbicide resistance status of sourgrass
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Amaral, Gabriel S.
; Silveira, Hellen M.
; Mendes, Kassio F.
; Silva, Antônio J.M
; Silva, Maria F. G. F.
; Carbonari, Caio A.
; la Cruz, Ricardo Alcántara-de
.
Abstract Sourgrass [ Digitaria insularis (L.) Mez ex Ekman] is one of the most challenging herbicide-resistant weeds in the grain-producing areas of Southeast, Central-west, and Northeast of Brazil. This species is a perennial grass that is highly competitive with the C4 photosynthetic pathway. It easily adapts to different environments and reproduces through both seed and rhizomes. The objective of this review was to compile what is known about sourgrass biology, the state of herbicide resistance and its associated mechanisms, and main weed management strategies. The high seed viability, ease of dispersal and the strong propensity to develop resistance to herbicides like glyphosate and acetyl coenzyme A carboxylase (ACCase) inhibitors in the prevalent no-tillage system in Brazil make the sourgrass one of the most difficult weeds to control. Due to the great genetic variability, the resistance mechanisms conferring glyphosate-resistance among sourgrass populations range from reduced absorption, altered translocation, enhanced metabolism, target-site mutations, and 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) overexpression. In addition, Trp2027Cys mutation was found to confer cross-resistance to ACCase inhibitors. Sourgrass management strategies include herbicide rotation, herbicide tank mix or sequential applications, as well as the use of mulch to reduce infestations. These measures must be implemented before crop sowing because the range of management options is greater than in after crop sowing. Additionally, the best control of sourgrass is achieved when management is carried out during the early growth stages, before the plants develop rhizomes and form clumps. L. L (L. Ekman herbicideresistant resistant grainproducing grain producing Southeast Centralwest, Centralwest Central west, west Central-west C pathway biology viability (ACCase notillage no tillage variability glyphosateresistance absorption translocation metabolism targetsite target site mutations 5enolpyruvylshikimate3phosphate enolpyruvylshikimatephosphate 5 enolpyruvylshikimate 3 phosphate EPSPS (EPSPS overexpression addition TrpCys Trp Cys crossresistance cross rotation applications infestations Additionally stages clumps (L
14.
Sou uma rede de narrativas: aproximações entre Paul Ricoeur e Alice Munro
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RESUMO: Neste artigo, pretendemos abordar o papel da memória e da narrativa na constituição da identidade pessoal, a partir de conceitos teóricos da obra de Paul Ricoeur (em especial O si-mesmo como outro) e da análise do conto “O urso atravessou a montanha”, de Alice Munro. Esse movimento nos permitirá sublinhar a ideia de que, contrariamente ao que parte da literatura sobre identidade e narrativa tem sustentado, não é só aquilo que poderíamos chamar de autonarrativa que cumpre um papel na manutenção da identidade pessoal. Ao invés disso, recuperamos a ideia ricoeuriana de uma rede de narrativas ou emaranhado de histórias, na qual auto- e heteronarrativas se imbricam mutuamente, servindo de sustentáculos para as identidades constituídas sobre ela.
ABSTRACT: In this article, we intend to address the role of memory and narrative in the constitution of personal identity, based on Alice Munro’s short story “The Bear Came Over the Mountain” and the theoretical concepts of Paul Ricoeur (especially in Oneself as Another). This movement will allow us to underscore the idea that, contrary to what part of the analytical literature on identity and narrative has held, it is not just what we might call self-narrative that plays a role in maintaining personal identity. Instead, we recover the Ricoeurian idea of a network of narratives or tangled of stories, in which self- and hetero-narratives are entangled, thus providing support to the identities it captures.
15.
[SciELO Preprints] - Guideline of the Brazilian Society of Cardiology on Diagnosis and Treatment of Patients with Chagas Disease Cardiomyopathy
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Marin-Neto, José Antonio
Rassi Jr., Anis
Moraes Oliveira, Gláucia M.
Lemos Correia, Luís Claudio
Novaes Ramos Jr., Alberto
Hasslocher-Moreno, Alejandro Marcel
Luquetti Ostermayer, Alejandro
Sousa, Andréa Silvestre de
Amato Vincenzo de Paola, Angelo
Sobral de Sousa, Antonio Carlos
Pinho Ribeiro, Antonio Luiz
Correia Filho, Dalmo
Moraes de Souza, Dilma do Socorro
Cunha-Neto, Edecio
J. A. Ramires, Felix
Bacal, Fernando
Pereira Nunes, Maria do Carmo
Martinelli Filho, Martino
Ibrahim Scanavacca, Maurício
Magalhães Saraiva, Roberto
Alves de Oliveira Júnior, Wilson
M. Lorga-Filho, Adalberto
de Jesus Benevides de Almeida Guimarães, Adriana
Lopes Latado Braga, Adriana
Sarmento de Oliveira, Adriana
V. L. Sarabanda, Alvaro
Yecê das Neves Pinto, Ana
Assis Lopes do Carmo, André
Schmidt, André
Costa, Andréa Rodrigues da
Ianni, Barbara Maria
Markman Filho, Brivaldo
Eduardo Rochitte, Carlos
Thé Macedo, Carolina
Mady, Charles
Chevillard, Christophe
Bittencourt das Virgens, Cláudio Marcelo
Nery de Castro, Cleudson
De Paoli de Carvalho Britto, Constança Felícia
Pisani, Cristiano
do Carmo Rassi, Daniela
C. Sobral Filho, Dario
Rodrigues Almeida, Dirceu
A. Bocchi, Edimar
T. Mesquita, Evandro
de Souza Nogueira Sardinha Mendes, Fernanda
Pereira, Francisca Tatiana
Sperandio da Silva, Gilberto Marcelo
de Lima Peixoto, Giselle
Glotz de Lima, Gustavo
H. Veloso, Henrique
Turin Moreira, Henrique
Bellotti Lopes, Hugo
Masciarelli Francisco Pinto, Ibraim
Pinto Dias, João Carlos
Bemfica, João Marcos
Silva-Nunes, João Paulo
Soares Barreto-Filho, José Augusto
Kerr Saraiva, José Francisco
Lannes-Vieira, Joseli
Menezes Oliveira, Joselina Luzia
V. Armaganijan, Luciana
Martins, Luiz Cláudio
C. Sangenis, Luiz Henrique
Barbosa, Marco Paulo
Almeida-Santos, Marcos Antônio
Simões, Marcos Vinicius
Shikanai-Yasuda, Maria Aparecida
Vieira Moreira, Maria da Consolação
Higuchi, Maria de Lourdes
Costa Monteiro, Maria Rita de Cássia
Felix Mediano, Mauro Felippe
Maia Lima, Mayara
T. Oliveira, Maykon
Moreira Dias Romano , Minna
Nitz, Nadjar
de Tarso Jorge Medeiros, Paulo
Vieira Alves, Renato
Alkmim Teixeira, Ricardo
Coury Pedrosa, Roberto
Aras, Roque
Morais Torres, Rosália
dos Santos Povoa, Rui Manoel
Rassi, Sérgio Gabriel
Salles Xavier, Sérgio
Marinho Martins Alves , Silvia
B. N. Tavares, Suelene
Lima Palmeira, Swamy
da Silva Junior, Telêmaco Luiz
da Rocha Rodrigues, Thiago
Madrini Junior, Vagner
Maia da Costa , Veruska
Dutra, Walderez
This guideline aimed to update the concepts and formulate the standards of conduct and scientific evidence that support them, regarding the diagnosis and treatment of the Cardiomyopathy of Chagas disease, with special emphasis on the rationality base that supported it.nbsp;
Chagas disease in the 21st century maintains an epidemiological pattern of endemicity in 21 Latin American countries. Researchers and managers from endemic and non-endemic countries point to the need to adopt comprehensive public health policies to effectively control the interhuman transmission of T. cruzi infection, and to obtain an optimized level of care for already infected individuals, focusing on diagnostic and therapeutic opportunistic opportunities.
nbsp;
Pathogenic and pathophysiological mechanisms of the Cardiomyopathy of Chagas disease were revisited after in-depth updating and the notion that necrosis and fibrosis are stimulated by tissue parasitic persistence and adverse immune reaction, as fundamental mechanisms, assisted by autonomic and microvascular disorders, was well established. Some of them have recently formed potential targets of therapies.nbsp;
The natural history of the acute and chronic phases was reviewed, with enhancement for oral transmission, indeterminate form and chronic syndromes. Recent meta-analyses of observational studies have estimated the risk of evolution from acute and indeterminate forms and mortality after chronic cardiomyopathy. Therapeutic approaches applicable to individuals with Indeterminate form of Chagas disease were specifically addressed. All methods to detect structural and/or functional alterations with various cardiac imaging techniques were also reviewed, with recommendations for use in various clinical scenarios. Mortality risk stratification based on the Rassi score, with recent studies of its application, was complemented by methods that detect myocardial fibrosis.nbsp;
The current methodology for etiological diagnosis and the consequent implications of trypanonomic treatment deserved a comprehensive and in-depth approach. Also the treatment of patients at risk or with heart failure, arrhythmias and thromboembolic events, based on pharmacological and complementary resources, received special attention. Additional chapters supported the conducts applicable to several special contexts, including t. cruzi/HIV co-infection, risk during surgeries, in pregnant women, in the reactivation of infection after heart transplantation, and others.nbsp; nbsp;nbsp;
Finally, two chapters of great social significance, addressing the structuring of specialized services to care for individuals with the Cardiomyopathy of Chagas disease, and reviewing the concepts of severe heart disease and its medical-labor implications completed this guideline.
Esta diretriz teve como objetivo principal atualizar os conceitos e formular as normas de conduta e evidências científicas que as suportam, quanto ao diagnóstico e tratamento da CDC, com especial ênfase na base de racionalidade que a embasou.
A DC no século XXI mantém padrão epidemiológico de endemicidade em 21 países da América Latina. Investigadores e gestores de países endêmicos e não endêmicos indigitam a necessidade de se adotarem políticas abrangentes, de saúde pública, para controle eficaz da transmissão inter-humanos da infecção pelo T. cruzi, e obter-se nível otimizado de atendimento aos indivíduos já infectados, com foco em oportunização diagnóstica e terapêutica.
Mecanismos patogênicos e fisiopatológicos da CDC foram revisitados após atualização aprofundada e ficou bem consolidada a noção de que necrose e fibrose sejam estimuladas pela persistência parasitária tissular e reação imune adversa, como mecanismos fundamentais, coadjuvados por distúrbios autonômicos e microvasculares. Alguns deles recentemente constituíram alvos potenciais de terapêuticas.
A história natural das fases aguda e crônica foi revista, com realce para a transmissão oral, a forma indeterminada e as síndromes crônicas. Metanálises recentes de estudos observacionais estimaram o risco de evolução a partir das formas aguda e indeterminada e de mortalidade após instalação da cardiomiopatia crônica. Condutas terapêuticas aplicáveis aos indivíduos com a FIDC foram abordadas especificamente. Todos os métodos para detectar alterações estruturais e/ou funcionais com variadas técnicas de imageamento cardíaco também foram revisados, com recomendações de uso nos vários cenários clínicos. Estratificação de risco de mortalidade fundamentada no escore de Rassi, com estudos recentes de sua aplicação, foi complementada por métodos que detectam fibrose miocárdica.
A metodologia atual para diagnóstico etiológico e as consequentes implicações do tratamento tripanossomicida mereceram enfoque abrangente e aprofundado. Também o tratamento de pacientes em risco ou com insuficiência cardíaca, arritmias e eventos tromboembólicos, baseado em recursos farmacológicos e complementares, recebeu especial atenção. Capítulos suplementares subsidiaram as condutas aplicáveis a diversos contextos especiais, entre eles o da co-infecção por T. cruzi/HIV, risco durante cirurgias, em grávidas, na reativação da infecção após transplante cardíacos, e outros.nbsp;nbsp;nbsp;
Por fim, dois capítulos de grande significado social, abordando a estruturação de serviços especializados para atendimento aos indivíduos com a CDC, e revisando os conceitos de cardiopatia grave e suas implicações médico-trabalhistas completaram esta diretriz.nbsp;
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