Abstract Pathophysiological characteristics of obesity includes chronic inflammation. Complications in the respiratory tract are related to bodily problems, which lead to a restriction of lung function due to reduced volume, inducing an increase in respiratory work. SARS-CoV-2 has a high potential for contamination by respiratory secretions and, therefore, obesity is one of the main risk factors for complications. The relations between obesity and SARS-CoV-2 are complex, since the immunological agents that are activated by these processes are ubiquitous. It is well-known that network analysis can generate results about the dynamics of complex biological phenomena, such as signalling networks, neural networks, immunological networks, and so on. Here we propose and analysis and interpretation of the complex relationships between obesity and COVID-19 in a meta-analysis study using complex network modelling and the theoretical knockouts technique. In a complex network of this kind, vertices are considered as immunological agents and their relation as directed edges. We built two networks: one related to COVID-19 and obesity (synergy) and another only with COVID-19. In both networks, we have performed the knockout of all 52 vertices. These knockouts indicated that, besides the Infected Host Cell and COVID viral particle, IL-17; CD40, AR and AL channels; and Th17, were the most relevant agents in this complex network. Overall, our study indicated the superior role and importance of IL-17 in this context. Such result corroborates with the role of IL-17 in identification and prognosis of Acute Respiratory Discomfort Syndrome (ARDS). inflammation problems volume work SARSCoV2 SARSCoV SARS CoV 2 SARS-CoV- therefore complications ubiquitous wellknown well known phenomena networks on COVID19 19 COVID-1 metaanalysis meta technique kind edges synergy (synergy COVID19. 19. 5 particle IL17 IL 17 CD40 CD channels Th17 Th Overall IL-1 context ARDS. ARDS . (ARDS) SARS-CoV COVID1 1 COVID- IL1 CD4 Th1 IL- (ARDS

ABSTRACT Resistance training has shown the potential to contribute to better glycemic control in people with Type 1 Diabetes (T1D), however, there are contradictory results in this regard and a need to clarify the effects of isolated resistance training on glycemic control in T1D. The aim was to verify the effects of resistance training on the glycemic control of people with T1D. Original articles were selected, randomized and non-randomized clinical trials that aimed to verify chronic responses, through the concentrations of glycated hemoglobin (HbA1c), to a structured program of resistance exercise in the glycemia of patients with T1D. The following databases were searched; MEDLINE, PubMed, Web of Science, Scopus, ScienceDirect, LILACS, and SciELO. Five studies were included in the review. A reduction in HbA1c was observed (SMD = -0.568 ± 0.165 [95% CI = -0.891 to -0.246]; p = 0.001; I² = 82%) in patients undergoing resistance training, when compared to the control group (SMD = 1.006 ± 0.181 [95% CI = 0.653 to 1.360]; p <0.001). Two studies, with children and adolescents and longer interventions, demonstrated a significant reduction in HbA1c, increased strength, and an improved lipid profile. Resistance training was efficient for assisting in glycemic control in people with T1D and should be incorporated in treatment plans.

ABSTRACT Objective: To estimate the rate of change during exercise and during recovery in moderate-continuous exercise (MCE) and high-intensity intermittent exercise (HIIE) in children and adolescents with type 1 diabetes (T1D). Subjects and methods: Participants performed 2 sessions of exercise: thirty minutes of continuous activity on a cycle ergometer (60% of VO2max) and thirty minutes (60% VO2max) interspersed with five bouts of maximum intensity lasting ten seconds every five minutes. Capillary blood glucose was measured before and after each test. The glucose rate of change in exercise (RoCE) was calculated (final blood glucose – onset blood glucose/exercise time), and the glucose rate of change in recovery (RoCR) (blood glucose 30 minutes after exercise – end of exercise blood glucose/recovery time). Results: The study included thirty-one participants (aged 13 ± 1.88 years). A lower blood glucose reduction was observed in the HIIE group, as well as better recovery values before, after, and thirty minutes after the test, respectively (333.14 ± 69.53, 226.19 ± 68.05 and 201.77 ± 66.84 versus 211.36 ± 91.03, 155.98 ± 82,68 and 165.76 ± 72.94). Covariance analyses showed a significant difference in glycemic variation between continuous and intermittent protocols immediately after exercise (−2.90 versus −2.08) and during the recovery period (−0.677 versus −0.389). Conclusions: HIIE led to a lower glucose reduction rate per minute during exercise and better recovery in the first 30 minutes after exercise compared to MCE in children and adolescents with T1D.

Abstract Alzheimer's disease is the most common neurodegenerative disorder, with cognitive as well as behavioral manifestations. Also related to this pathology, is the decreased production and activation of some neurotransmitters, such as Serotonin, which is derived from the Tryptophan. Different methods to improve the effect and performance of some drugs have been studied including the Nanoparticles. The objective was to analyze the efficacy of L-tryptophan and L-tryptophan Nanoparticles in the acute response of motor and cognitive behavior in an Alzheimer's experimental model. Methods: 15 Wistar rats, divided into 3 groups (n = 5): GC (Alzheimer's control group), GLt (L-tryptophan), and GN (Nanoparticles). They were treated for six consecutive days. Anxiety tests, spatial memory tests, aversive memory tests, and motor behavior tests were all performed during this study. In the analysis of anxiety, improvement was observed in both treatments, being that GN presented improvement in two variables: freezing (79±18.8; 74.6±14.2) and TBF (287.8±1.08; 268±40.8). GLt only presented improvement in freezing (103.8±44.4). In the spatial memory analysis, there were no significant differences in aversive memory and motor behavior during the treatments. During the Size Effect analysis treatments, it is possible to observe some differences both in anxiety and motor behavior, precisely where NG presented better results than GLt. Even in a short period of time, the nanoparticles demonstrated great benefits as a treatment method. Conclusion: the use of nanoparticles is an effective treatment against changes in motor and cognitive behavior caused by Alzheimer´s, as it lowers anxiety and improves motor behavior.

ABSTRACT Objective To identify the level of physical activity and glycemic variability of adolescents with type 1 diabetes mellitus and to compare glycemic variability on days with different amounts of moderate to vigorous physical activity (MVPA). Subjects and methods A sample of 34 subjects aged 10 to 15 years, 18 (52.94%) female; age: 13.04 ± 1.94; HbA1c: 9.76 ± 1.51. Physical activity was measured by wGT3X accelerometer. The glucose data were obtained using continuous glucose monitoring, and the following glycemic variability measures were calculated: standard deviation (SD), low blood glucose index (LBGI), high blood glucose index (HBGI), mean amplitude of glycemic excursions (MAGE), glycemic risk assessment in diabetes equation (GRADE) and coefficient of variation (CV). The most and least active days (the days with greater and lesser time dedicated to physical activities of moderate to vigorous intensity, respectively) were identified. In addition, based on the whole period of accelerometer use, daily means of time spent in MVPA were identified among participants, who were then divided into three groups: up to 100 minutes; from 101 to 200 minutes and above 201 minutes. Then, the measures of glycemic variability were compared among the most and least active days and among the groups too. Results The amount of MVPA was significantly different between the days evaluated (237.49 ± 93.29 vs. 125.21 ± 58.10 minutes), but glycemic variability measures did not present a significant difference. Conclusion Despite the significant differences in the amount of MVPA between the two days evaluated, the glycemic variability did not change significantly. Arch Endocrinol Metab. 2020;64(3):312-8

RESUMO A Diabetes Mellitus Tipo 1 (DM1) é uma doença autoimune que afeta milhares de pessoas atualmente, com maior concentração de casos na adolescência. O tratamento implica alterações no estilo de vida que podem apresentar influência negativa sobre a qualidade do sono (QS) e qualidade de vida (QV). O propósito do estudo foi comparar a QS e QV entre adolescentes portadores e não portadores de DM1. Participaram do estudo 74 adolescentes divididos por grupos e sexo: GDM1-F (n=19), GDM1-M (n=18), GC-F (n=21) e GC-M (n=16). Os instrumentos utilizados foram o Índice de Qualidade do Sono de Pittsburgh e WHOQOL-bref. Para comparar os grupos foi utilizado Análise de Covariância, ajustada pela idade, com Post Hoc de Bonferroni. Os resultados sinalizam que os participantes do GDM1-F e GDM1-M, portadores de DM1, apresentaram maiores escores em todas as avaliações, com diferença significativa com o CG-F nas variáveis: QS global, Domínios Físico, Psicológico e Relações Sociais e QV total. Portanto, foi possível observar que os adolescentes portadores de DM1 apresentaram melhor avaliação da QS e QV em comparação as meninas sem DM1, independentemente da idade.

ABSTRACT Type 1 Diabetes Mellitus (DM1) is an autoimmune disease that affects thousands of people today, with a higher concentration of cases in adolescence. Treatment involves lifestyle changes that can have a negative influence on quality of sleep (QS) and quality of life (QL). The purpose of the study was to compare QS and QL among adolescents with and without DM1. Seventy-four adolescents participated in the study divided by groups and sex: GDM1-F (n=19), GDM1-M (n=18), GC-F (n=21) and GC-M (n=16). The instruments used were the Pittsburgh Sleep Quality Index and WHOQOL-bref. Age-adjusted Covariance Analysis with Bonferroni Post Hoc was used to compare the groups. The results show that the participants of GDM1-F and GDM1-M, with DM1, had higher scores in all evaluations, with significant difference with CG-F in the variables: global QS, Physical, Psychological and Social Relationships and total QL. Therefore, it was possible to observe that adolescents with DM1 had better QS and QL evaluations than girls without DM1, regardless of age.

RESUMO Objetivo: Comparar as taxas máximas de oxidação da gordura (FATMAX) e analisar a sua associação com a aptidão cardiorrespiratória em adolescentes com diabetes mellitus tipo 1 (DM1). Métodos: Vinte e dois adolescentes de ambos os sexos, de 11 a 17 anos, após avaliações clínicas e antropométricas, foram alocados no grupo diabético (GD; n = 10) ou no grupo controle (GC; n = 12). A aptidão cardiorrespiratória foi determinada pelo consumo máximo de oxigênio (VO2max) durante um teste aeróbico máximo em um cicloergômetro utilizando o protocolo Balke. A oxidação máxima da gordura (FATMAX) foi determinada pela razão de troca ventilatória proposta na Tabela de Lusk. Resultados: Os adolescentes no GD apresentaram menores valores médios de FATMAX (p<0,01) e % VO2FATMAX (p=0,001) quando comparados com aqueles no GC. Os valores de FATMAX correlacionaram-se inversamente com os níveis de hemoglobina glicosilada sérica (HbA1c) (r = −0,77) e diretamente com o z-score IMC (r = 0,76), enquanto os resultados de %VO2FATMAX correlacionaram-se diretamente com a idade (r = 0,81), z-score IMC (r = 0,65) e VO2max (r = 0,81). Na regressão linear múltipla, os valores de HbA1c explicaram 54% (r² ajustado = 0,54, p = 0,009) e o z-score IMC explicou 3,1% (r² ajustado = −0,031, p = 0,009) da variação no FATMAX no GD. Os adolescentes com DM1 apresentaram aptidão cardiorespiratória similar e taxas de FATMAX menores (35±11 VO2max) quando comparados com os do grupo controle (60±12 VO2max). Conclusão: Esses resultados sugerem taxas menores de oxidação da gordura e maior uso da glicose como substrato de energia durante o exercício e pior controle no DM1. Portanto, os resultados podem contribuir com a prescrição de exercício apropriada no DM1, após verificar a intensidade do exercício, a fim de diminuir o risco de hipoglicemia. Nível de evidência III; Estudo de caso-controle.

ABSTRACT Objective: To compare maximal fat oxidation rates (FATMAX) and analyze their association with cardiorespiratory fitness in adolescents with type 1 diabetes mellitus (T1DM). Methods: Twenty-two male and female adolescents aged between 11 to 17 years, following clinical and anthropometric evaluations, were assigned to the diabetic group (DG; n = 10) or control group (CG; n = 12). Cardiorespiratory fitness was determined by maximal oxygen uptake (VO2max) during a maximal aerobic test on a cycle ergometer using the Balke protocol. Maximal fat oxidation (FATMAX) was determined by the respiratory exchange ratio proposed in the Lusk table. Results: Adolescents in the DG had lower mean FATMAX (p<0.01) and %VO2FATMAX (p=0.001) values when compared with those in the CG. FATMAX values were inversely correlated with serum glycosylated hemoglobin (HbA1c) levels (r= −0.77) and directly correlated with BMI z-scores (r=0.76), while %VO2FATMAX results were correlated with age (r=0.81), BMI z-scores (r=0.65), and VO2max values (r=0.81). On multiple linear regression, HbA1c values explained 54% (adjusted r²=0.54, p=0.009) and BMI z-scores explained 3.1% (adjusted r²=-0.031, p=0.009) of the variation in FATMAX in the DG. Adolescents with T1DM had similar cardiorespiratory fitness and lower FATMAX rates (35±11 VO2max) when compared with controls (60±12 VO2max). Conclusion: These results suggest lower fat oxidation rates and greater use of glucose as an energy substrate during exercise and worse control in T1DM. Therefore, results may contribute to appropriate exercise prescription in T1DM, after verifying exercise intensity to reduce hypoglycemia risk. Level of evidence III; Case-control study.

RESUMEN Objetivo: Comparar las tasas máximas de oxidación de la grasa (FATMAX) y analizar su asociación con la aptitud cardiorrespiratoria en adolescentes con diabetes mellitus tipo 1 (DM1). Métodos: Veintidós adolescentes de ambos sexos, de 11 a 17 años, después de evaluaciones clínicas y antropométricas, fueron asignados en el grupo diabético (GD, n = 10) o en el grupo control (GC, n = 12). La aptitud cardiorrespiratoria fue determinada por el consumo máximo de oxígeno (VO2max) durante un test aeróbico máximo en un cicloergómetro utilizando el protocolo Balke. La oxidación máxima de la grasa (FATMAX) fue determinada por la razón de cambio ventilatorio propuesta en la Tabla de Lusk. Resultados: Los adolescentes en el GD presentaron menores valores promedio de FATMAX (p<0,01) y % VO2FATMAX (p=0,001) cuando comparados con aquellos en el GC. Los valores de FATMAX se correlacionaron inversamente con los niveles de hemoglobina glicosilada sérica (HbA1c) (r = −0,77) y directamente con el z-score IMC (r = 0,76), mientras que los resultados de %VO2FATMAX se correlacionaron directamente con la edad (r = 0,81), z-score IMC (r = 0,65) y VO2max (r = 0,81). En la regresión lineal múltiple, los valores de HbA1c explicaron 54% (r² ajustado = 0,54, p = 0,009) y el z-score IMC explicó 3,1% (r² ajustado = −0,031, p = 0,009) de la variación en el FATMAX en el GD. Los adolescentes con DM1 presentaron aptitud cardiorrespiratoria similar y tasas de FATMAX menores (35±11 VO2max) cuando comparados con los del grupo control (60±12 VO2max). Conclusión: Esos resultados sugieren tasas menores de oxidación de la grasa y mayor uso de la glucosa como substrato de energía durante el ejercicio y peor control en la DM1. Por lo tanto, los resultados pueden contribuir con la prescripción de ejercicio apropiada en la DM1, después de verificar la intensidad del ejercicio, a fin de disminuir el riesgo de hipoglucemia. Nivel de evidencia III; Estudio de caso-control.

RESUMO Introdução: Existem várias técnicas para avaliar a composição corporal, dentre elas o DEXA, porém apresenta alto custo. O índice de massa corporal (IMC) se apresenta como método mais utilizado. Entretanto, o mesmo apresenta limitações. Objetivo: Verificar a aplicabilidade de uma nova equação do IMC e associar com o absortometria de Raio-x de Dupla Energia (DEXA) em adolescentes com diabetes mellitus tipo 1. Métodos: Pesquisa intencional composta por 30 adolescentes (15 meninos e 15 meninas), com idades entre 10 e 15 anos. Foi avaliada a estatura e a massa corporal para a obtenção dos IMC2.5 e oIMC2 . O percentual de gordura foi obtido através do DEXA. A hemoglobina glicada foi verificada por meio do teste imunoturbidimétrico TurbiClin. Para análise dos dados foi realizada a média, desvio padrão e percentual de frequência. A correlação entre as variáveis dos IMC, DEXA e hemoglobina glicada, foi avaliada pelo coeficiente de correlação de Pearson. Adotou-se um nível de significância de p < 0,05. Resultados: A nova equação do IMC2.5 apresentou associação com IMC2.5 Escore Z (r=0,68; p=0,001), IMC2 (r=0,99; p=0,001), IMC2 Escore Z (r=0,67; p=0,001) e DEXA (r=0,58; p=0,05). Enquanto, o IMC2.5 Escore Z demonstrou associação positiva com oIMC2 (r=0,70; p=0,001) e IMC2 Escore Z (r=1,0; p=0,001). Conclusão: Para os adolescentes com diabetes mellitus tipo 1 tanto faz a equação utilizada para estimar o estado nutricional, pois a imprecisão de ambos os IMC continua a mesma para determinar percentual de gordura. O mesmo ocorre quando transformado em IMC2.5 escore Z, o nível de correlação continua semelhante.

ABSTRACT Introduction: There are several techniques to evaluate body composition, among them DEXA stands out, but presents a high cost. On the other hand, body mass index (BMI) is the most used method. However, it has limitations. Objective: To verify the applicability of a new BMI equation and to associate it with dual energy X‐ray absorptiometry (DXA) in adolescents with DM1. Methods: This research of intentional characteristics was composed of 30 adolescents (15 boys and 15 girls), aged between 10 and 15 years. Stature and body mass were evaluated to obtain BMI2.5and BMI2. The percentage of fat (%BF) was obtained through DXA. The glycated hemoglobin (HbA1c) was verified by mean soft he TurbiClin immunoturbidimetric test. Descriptive statistics (mean, standard deviation and percentage of frequency) were used to analyze the data. The correlation between the variables (BMI, DXA and HbA1c) was evaluated by the Pearson correlation coefficient. We adopted a significance level of p < 0.05. Results: The new equation of BMI2.5 was associated with BMI2.5 Z score (r= 0.68, p= 0.001), BMI2 (r= 0.99, p= 0.001), BMI2 Z score (r= 0.67, p= 0.001) and DEXA (r= 0.58, p= 0.05). Meanwhile, BMI2.5 Z score showed a positive association with BMI2 (r= 0.70, p= 0.001) and BMI2 Z score (r= 1.0, p= 0.001). Conclusion: We can highlight that for adolescents with DM1, the equation used to estimate the nutritional status is the same, since the imprecision of both BMI remains the same to determine %G. The same occurs when transformed into BMI2.5 Z score, the level of correlation continues similar.

RESUMEN Introducción: Existen varias técnicas para evaluar la composición corporal, entre ellas destaca el DEXA, pero presenta alto costo. Por otro lado, el índice de masa corporal (IMC) se presenta como método más utilizado. Sin embargo, el mismo presenta limitaciones. Objetivo: Verificar la aplicabilidad de una nueva ecuación del IMC y asociarse con la absorciometría con rayos X de doble energía DEXA en adolescentes con DM1. Métodos: Esta investigación de característica intencional fue compuesta por 30 adolescentes (15 niños y 15 niñas), con edades entre 10 y 15 años. Se evaluó la estatura y la masa corporal para la obtención de los IMC2.5 y el IMC2. El porcentaje de grasa (%G) se obtuvo a través del DEXA. La hemoglobina glucosa (HbA1c) se verificó mediante la prueba inmunoturbidimétrica TurbiClin. Para el análisis de los datos se realizó la estadística descriptiva (media, desviación estándar y porcentaje de frecuencia). La correlación entre las variables (IMC, DEXA y HbA1c) fue evaluada por el coeficiente de correlación de Pearson. Se adoptó un nivel de significancia de p < 0,05. Resultados: La nueva ecuación del IMC2.5 presentó asociación con IMC2.5 Escore Z (r= 0,68; p= 0,001), IMC2 (r= 0,99; p= 0,001), IMC2 Escore Z (r = 0,67; p = 0,001) y DEXA (r = 0,58; p = 0,05). Mientras que el IMC2.5 Escore Z demostró asociación positiva con el IMC2 (r = 0,70; p = 0,001) e IMC2 Escore Z (r = 1,0; p = 0,001). Conclusión: Podemos destacar que para los adolescentes con DM1 tanto hace la ecuación utilizada para estimar el estado nutricional, pues la imprecisión de ambos IMC continúa siendo la misma para determinar %G. Lo mismo ocurre cuando se convierte en IMC2.5.

RESUMO Introdução: O envelhecimento causa alterações de diversas funções executivas e cognitivas, principalmente relacionadas à incidência de demências, em especial, a doença Alzheimer (DA). Diversos estudos mencionam o exercício físico como um recurso preventivo de sintomas de depressão. Objetivo: Investigar as alterações cognitivas e comportamentais relacionadas à DA capazes de retardar a progressão da doença e suas complicações. Métodos: A amostra foi composta por 10 ratos Wistar machos divididos em 2 grupos (n = 5), Natação e Alzheimer+Natação, com protocolo de 6 dias de intervenção. Foram realizadas avaliações da ansiedade pelo teste de labirinto elevado em cruz, memória espacial pelo labirinto aquático de Morris, memória aversiva pelo teste de aversão em caixa de isolamento e comportamento motor por meio do teste Open Field. Resultados: No grupo Natação houve melhora na memória espacial (169 ± 142,9 x 24,2 ± 31,3), porém verificou-se comportamento motor pior depois do exercício. Igualmente, observou-se aumento do comportamento de ansiedade (8 ± 13,03 x 67,8 ± 48,1) nos animais com DA, característica relevante da doença, que não apresentou melhora após o exercício agudo. Através da análise do Size effect foi possível observar que houve diferença no grupo Alzheimer+Natação na diminuição da ansiedade e melhora do comportamento motor após o exercício. Apesar dos benefícios do exercício físico para os sintomas da DA, ainda não existe um consenso sobre o tipo de exercício e o tempo de intervenção necessários para que se tenha uma resposta positiva como método de tratamento, uma vez que ainda não existem estudos que comprovem esse fato de maneira aguda ou crônica. Conclusão: O exercício físico de forma aguda não se mostrou totalmente eficaz como tratamento das alterações comportamentais com relação à DA, porém obteve um efeito médio na análise pelo Size effect sobre o comportamento motor e a ansiedade, especificamente. Nível de evidência IV; Investigação dos resultados do tratamento.

ABSTRACT Introduction: Aging causes alterations in various executive and cognitive functions, mainly related to the incidence of dementia, especially Alzheimer's disease (AD). Several studies mention physical exercise as a preventive resource for depressive symptoms. Objective: To investigate the cognitive and behavioral alterations related to AD that are capable of slowing disease progression and its complications. Methods: The sample consisted of 10 male Wistar rats, divided into 2 groups (n = 5), swimming and Alzheimer + swimming, with a 6-day intervention protocol. The elevated plus maze test was used to assess anxiety, the Morris water maze for spatial memory, the isolation box for aversive memory, and the open field test to assay motor behavior. Results: There was improvement in spatial memory in the Swimming group (169 ± 142.9 x 24.2 ± 31.3), but motor behavior deteriorated after exercise. An increase in anxious behavior (8 ± 13.03 x 67.8 ± 48.1) was observed in the animals with AD. This is a relevant characteristic of the disease, which did not improve after acute exercise. By analyzing the size effect, it was possible to observe a difference in the Alzheimer + swimming group in terms of reduced anxiety and improved motor behavior after exercise. Despite the benefits of physical exercise for AD symptoms, there is still no consensus on the type of physical exercise and length of intervention necessary to achieve a positive response as a treatment method, since studies are yet to confirm this fact in an acute or chronic manner. Conclusion: Acute physical exercise was not fully effective as a means of treating behavioral alterations related to AD, but had a mean effect on the size effect analysis of motor behavior and anxiety, specifically. Level of evidence IV; Investigation of treatment outcomes.

RESUMEN Introducción: El envejecimiento causa cambios de diversas funciones ejecutivas y cognitivas, relacionadas con la incidencia de demencias, en especial, la enfermedad de Alzheimer (EA). Diversos estudios mencionan el ejercicio físico como un recurso preventivo de síntomas de depresión. Objetivo: Investigar las alteraciones cognitivas y de comportamiento relacionadas a la EA capaces de retardar la progresión de la enfermedad y sus complicaciones. Métodos: Diez ratas Wistar machos divididas en 2 grupos (n = 5), Natación y Alzheimer+natación, con protocolo de intervención de 6 días. Se realizaron evaluaciones de la ansiedad por la prueba del laberinto elevado en cruz, memoria espacial por el laberinto acuático de Morris, memoria aversiva por la prueba de aversión en caja de aislamiento y comportamiento motor por de la prueba de campo abierto. Resultados: En el grupo Natación hubo mejoría en la memoria espacial (169 ± 142,9 x 24,2 ± 31,3), pero se observó comportamiento motor peor después del ejercicio. También se observó un aumento del comportamiento de ansiedad (8 ± 13,03 x 67,8 ± 48,1) en los animales con EA, característica relevante de la enfermedad, que no presentó mejoría después del ejercicio agudo. A través del análisis del Size effect fue posible observar que hubo diferencia en el grupo Alzheimer+Natación en la reducción de la ansiedad y de mejora del comportamiento motor después del ejercicio. A pesar de los beneficios del ejercicio físico en los síntomas de la EA, todavía no hay consenso sobre el tipo de ejercicio físico y el tiempo de intervención necesarios para tener una respuesta positiva como método de tratamiento, ya que aún no existen estudios que demuestren ese tipo de hecho agudo o crónico. Conclusión: El ejercicio físico de forma aguda no fue totalmente eficaz como tratamiento de las alteraciones de comportamiento con relación a la EA, pero obtuvo un efecto promedio en el análisis por el Size effect sobre el comportamiento motor y la ansiedad, específicamente. Nivel de evidencia IV; Investigación de los resultados del tratamiento.

Resumo O nível de atividade física e o autoconceito de autoestima são fatores adjacentes do status de saúde da população. Assim, o objetivo desta pesquisa foi analisar a associação entre nível de atividade física e autoconceito de autoestima de adolescentes. A amostra foi constituída por 98 sujeitos com média de 16,7 ± 1,2 anos. Utilizou-se dois instrumentos: Questionário Internacional de Atividade Física – versão curta e Escala de Autoestima de Rosenberg. A regressão logística binária (Odds Ratio) com α de 5% foi utilizada. As evidências teóricas giraram em torno da abordagem contemporânea do conceito de saúde e os resultados foram discutidos à luz da teoria comportamental do adolescente. Houve predominância de adolescentes ativos (41,8%), bem como menor proporção de sedentários (4,1%). Apresentaram autoestima elevada 55,1%, enquanto 44,9% revelaram a ter baixa. Conclui-se que não houve associação (Wald F = 2,756; p = 0,600) entre nível de atividade física e autoconceito de autoestima. Por fim, discutiu-se elementos comportamentais do adolescente que apontam lócus às futuras intervenções relativas ao tema com este público.

Abstract Physical activity levels and the self-perception of self-esteem are kindred factors of the health status of the population. Therefore, the scope of this research was to analyze the association between physical activity levels and adolescents’ self-perception of self-esteem. The sample consisted of 98 individuals with an average age of 16.7 ± 1.2. Two tools were used: The International Physical Activity Questionnaire – short version, and the Rosenberg Self-Esteem Scale. Binary logistic regression (Odds Ratio) with α of 5% was then applied. The theoretical evidence revolved around the contemporary approach to the definition of health; and the results were discussed in the light of the behavioral theory of the adolescent. There was a predominance of active adolescents (41.8%), as well as a smaller proportion of sedentary adolescents (4.1%). A total of 55.1% had high self-esteem, while 44.9% were found to have low self-esteem. The conclusion drawn is that there was no association (Wald F = 2.756; p = 0.600) between the level of physical activity and the self-perception of self-esteem. Lastly, the behavioral aspects of the adolescent that point to future potential areas of investigation related to the theme of this group were discussed.

Resumo O nível de atividade física e o autoconceito de autoestima são fatores adjacentes do status de saúde da população. Assim, o objetivo desta pesquisa foi analisar a associação entre nível de atividade física e autoconceito de autoestima de adolescentes. A amostra foi constituída por 98 sujeitos com média de 16,7 ± 1,2 anos. Utilizou-se dois instrumentos: Questionário Internacional de Atividade Física – versão curta e Escala de Autoestima de Rosenberg. A regressão logística binária (Odds Ratio) com α de 5% foi utilizada. As evidências teóricas giraram em torno da abordagem contemporânea do conceito de saúde e os resultados foram discutidos à luz da teoria comportamental do adolescente. Houve predominância de adolescentes ativos (41,8%), bem como menor proporção de sedentários (4,1%). Apresentaram autoestima elevada 55,1%, enquanto 44,9% revelaram a ter baixa. Conclui-se que não houve associação (Wald F = 2,756; p = 0,600) entre nível de atividade física e autoconceito de autoestima. Por fim, discutiu-se elementos comportamentais do adolescente que apontam lócus às futuras intervenções relativas ao tema com este público.

Abstract Physical activity levels and the self-perception of self-esteem are kindred factors of the health status of the population. Therefore, the scope of this research was to analyze the association between physical activity levels and adolescents’ self-perception of self-esteem. The sample consisted of 98 individuals with an average age of 16.7 ± 1.2. Two tools were used: The International Physical Activity Questionnaire – short version, and the Rosenberg Self-Esteem Scale. Binary logistic regression (Odds Ratio) with α of 5% was then applied. The theoretical evidence revolved around the contemporary approach to the definition of health; and the results were discussed in the light of the behavioral theory of the adolescent. There was a predominance of active adolescents (41.8%), as well as a smaller proportion of sedentary adolescents (4.1%). A total of 55.1% had high self-esteem, while 44.9% were found to have low self-esteem. The conclusion drawn is that there was no association (Wald F = 2.756; p = 0.600) between the level of physical activity and the self-perception of self-esteem. Lastly, the behavioral aspects of the adolescent that point to future potential areas of investigation related to the theme of this group were discussed.

RESUMO Objetivo: Associar o Consumo Máximo de Oxigênio (VO2máx) com o % de Gordura Corporal (%GC) e estabelecer o melhor ponto de corte do VO2máx para a previsão do %GC de risco em adolescentes. Métodos: Estudo realizado com uma amostra de 979 sujeitos entre 10 e 18,8 anos, sendo 556 (56,8%) meninas. O protocolo shuttle run de 20 m determinou o VO2máx, que foi analisado em quintil e escala numérica. Equações de dobras cutâneas determinaram o %GC, posteriormente classificado como risco à saúde/obesidade quando >25, para meninas, e >20, para meninos. Utilizou-se regressão - Odds Ratio (OR) e Curva Característica de Operação do Receptor (curva ROC) com α <5%. Resultados: Do total de casos válidos, 341 (65,6%) meninas e 202 (53,2%) meninos apresentaram %GC de risco, e constatou-se maior proporção do %GC de risco no 1º quintil do VO2máx para ambos os sexos. Houve associação inversa entre VO2máx e %GC de risco do 4º quintil (OR 1,84, IC95% 1,05-3,24) até o 1º quintil (OR 4,74, IC95% 2,44-9,19) para meninas, e do 2º quintil (OR 2,99, IC95% 1,48-6,00) até o 1º quintil (OR 5,60, IC95% 2,64-11,87) para meninos. Pontos de corte do VO2máx para previsão do %GC de risco ≤40,9 mL/kg-1/min-1 (Area Under the Curve (Área Sob a Curva) - AUC: 0,65; p<0,001) para meninas e ≤44,8 mL/kg-1/min-1 (AUC: 0,66; p<0,001) para meninos foram destaques analíticos. Conclusões: VO2máx esteve associado inversamente ao %GC, e os pontos de corte do VO2máx para a previsão do %GC de risco são resultados importantes para ações de combate à obesidade precoce.

ABSTRACT Objective: To associate the Maximal Oxygen Uptake (VO2max) with body fat percentage (%BF), and to establish the best VO2max cutoff point for predicting risk %BF in teenagers. Methods: This study was carried out with 979 subjects aged 10 to 18.8 years, 556 (56.8%) girls. The 20 m shuttle run protocol determined the VO2max, which was analyzed in quintiles and in a numeric scale. Cutaneous fold equations determined the %BF, later classified as risk to health/obesity when >25 in girls and >20 in boys. Regression method was used - Odds Ratio (OR) and Receiver Operating Characteristics Curve (ROC curve) with α <5%. Results: From the total number of valid cases, 341 (65.6%) girls and 202 (53.2%) boys presented %BF of risk, and a larger proportion of %BF of risk was observed in the 1st quintile of the VO2max for both genders. There was inverse association between VO2max and %BF of risk from the 4th quintile (OR 1.84, 95%CI 1.05-3.24) until the 1st quintile (OR 4.74, 95%CI 2.44-9.19) for girls, and from the 2nd quintile (OR 2.99, 95%CI 1.48-6.00) until the 1st quintile (OR 5.60, 95%CI 2.64-11.87) for boys. As analytic highlights, VO2max Cutoff points for prediction of %BF of risk were ≤40.9 mL/kg-1/min-1 (AUC: 0.65; p<0.001) for girls and ≤44.8 mL/kg-1/min-1 (AUC: 0.66; p<0.001)for boys.. Conclusions: VO2max was inversely associated to the %BF, and VO2max cutoff points for prediction of %BF of risk are important results to generate action to fight early obesity.

RESUMO O objetivo do estudo foi comparar o comportamento de parâmetros metabólicos, pressão arterial e indicadores de obesidade em crianças e adolescentes com e sem resistência à insulina. Participaram do estudo 60 crianças e adolescentes com excesso de peso (6 a 18 anos)que foram submetidos amedidas antropométricas de massa corporal (MC), estatura ecircunferência da cintura (CC), pressão arterial (PA), bioimpedância[gordura relativa (%G) e absoluta (GC)] e coleta sanguínea para determinação das concentrações de glicose, insulina e perfil lipídico (TG, CT, HDL-C, LDL-C). O IMC z-scorefoi empregado para classificação do estado nutricional e o índice HOMA-RI (>2,5) para resistência à insulina.Os participantes foram divididos em dois grupos, resistentes (RI, n=27) e não resistentes à insulina (NRI, n=33).Independente da idade, crianças e adolescentescom excesso de peso e RI, apresentaram maior MC, CC, IMC, %G e GC (kg), TG e insulina plasmática do que contraparesNRI, que por sua vez, apresentaram valores mais elevados de LDL-C. Os grupos não diferiram para oestado nutricional(IMC z-score)porém, na comparação entre as proporções indesejadas dos componentes metabólicos, apenas três apresentaram alterações com diferenças significativas entre os grupos (CT, LDL-C e TG). Conclui-se que a RI apresenta-se com influência para o desenvolvimento de dislipidemias nessa faixa etária em especial o TG.

ABSTRACT The aim of the study was to compare the behavior of metabolic parameters, blood pressure, and obesity indicators in children and adolescents with and without insulin resistance. Sixty-one overweight children (6 to 18 years) underwent anthropometric measurements of body mass (BM), height and waist circumference (WC), blood pressure (BP), bioimpedance (relative (%F) and absolute fat (BF)), and blood collection for determination of glucose, insulin, and lipid profile (TG, CT, HDL-C, LDL-C). The BMI z-score was used to classify nutritional status and the HOMA-IR index (> 2.5) for insulin resistance. Participants were divided into two groups, insulin resistant (IR, n= 27) and non-insulin resistant (NIR, n= 33). Regardless of age, children and adolescents with excess weight and IR presented higher BM, WC, BMI, %F and BF (kg), TG, and plasma insulin than their NIR counterparts, who in turn presented higher LDL-C. The groups did not differ in nutritional status (BMI z-score); however, in the comparison between the undesired proportions of the metabolic components, only three presented alterations with significant differences between the groups (TC, LDL-C, and TG). It is concluded that IR influences the development of dyslipidemias in this age group, especially TG.

Resumo O objetivo do presente estudo foi verificar o nível de concordância entre o Absortometria de Raio-x de Dupla Energia (DEXA) na avaliação do percentual de gordura de adolescentes com diabetes mellitus tipo 1 (DM1). A amostra foi constituída por 34 adolescentes (16 meninos e 18 meninas) com idades entre 10 e 15 anos. Coletaram-se os dados de estatura e circunferência do quadril para cálculo do IAC, bem como avaliação do percentual de gordura via DEXA. O teste de Shapiro Wilk foi utilizado para verificar a normalidade dos dados. O teste de Wilcoxon foi realizado para comparar as variáveis de idade, antropométricas e IMC score Z, IAC e DEXA entre sexos. A correlação das variáveis (IAC vs DEXA) foi avaliada pelo coeficiente de correlação de Spearman. Para análise dos escores residuais aplicou-se o teste de Bland-Altman. O coeficiente de Kappa (k) foi realizado para avaliar o nível de concordância entre o IAC e DEXA. Sendo assim, foi encontrada correlação fraca e não significante entre IAC e DEXA tanto nos meninos (r=0,19; p=0,46), quanto nas meninas (r=0,10; p=0,73). Dessa forma, foi possível perceber concordância fraca (k= 0,09) para ambos os sexos. Conclui-se que o IAC não é recomendado para estimar percentual de gordura em adolescentes com DM1.

ABSTRACT The aim of the present study was to verify the level of concordance between Body Adiposity Index (BAI) and Dual-energy X-ray Absorptiometry (DEXA) in the evaluation of body fat percentage in adolescents with type-1 diabetes mellitus (DM1). The sample consisted of 34 adolescents (16 boys and 18 girls) aged 10-15 years. Height and hip circumference data were collected for BAI calculation, and fat percentage was evaluated using DEXA. The Shapiro Wilk test was used to verify data normality. The Wilcoxon test was performed to compare age, anthropometric and BMI, BAI z score and DEXA between sexes. The correlation of variables (BAI vs DEXA) was evaluated by the Spearman correlation coefficient. For the analysis of residual scores, the Bland-Altman test was applied. The Kappa coefficient (k) was performed to assess the level of concordance between BAI and DEXA. Therefore, weak and non-significant correlation between BAI and DEXA in boys (r= 0.19, p= 0.46), and girls (r= 0.10, p= 0.73) was observed. Thus, weak concordance was observed (k= 0.09) for both sexes. It was concluded that BAI is not recommended to estimate fat percentage in adolescents with DM1.

RESUMO A qualidade de vida relacionada à saúde (HRQOL) no diabetes mellitus tipo 1 (T1DM) tem sido amplamente estudada. Os objetivos deste estudo foram avaliar e identificar os fatores que influenciam a HRQOL de crianças e adolescentes com T1DM. MATERIAL E MÉTODOS: No total, 59 pacientes (9-16 anos, T1DM por ≥1 ano) responderam a uma versão do Instrumento de Qualidade de Vida para Jovens com Diabetes (DQOLY) adaptada aos pacientes brasileiros (IQVJD). Esse instrumento compreende satisfação, impacto e preocupações de domínios, com os menores índices correspondentes a uma melhor HRQOL, e um questionário que reúne parâmetros sociais, demográficos e clínicos. RESULTADOS: A idade média foi de 13,6 anos e 57,6% eram meninas. A idade mediana no diagnóstico foi de 7,16 anos, 63% apresentaram cetoacidose diabética (DKA) no diagnóstico e 29% durante o seguimento. A hemoglobina glicada média (HbA1c) no ano anterior foi de 10%. Todos os pacientes receberam doses múltiplas de insulina (média de 4,2 aplicações/ dia), 74,5% utilizavam análogos de insulina de ação rápida e de ação intermediária e 67,8% usavam canetas para aplicação de insulina. Os resultados do DQOLY estavam dentro do limite de corte para melhor HRQOL. Uma análise isolada de cada domínio e os resultados do questionário mostraram que os seguintes fatores estavam associados a uma maior HRQOL: score z de altura, HbA1c menor, prática de atividade física, uso de caneta, menos hospitalizações e residência em uma área rural. Houve uma alta taxa de cetoacidose diabética no diagnóstico, e o controle metabólico foi inadequado na maioria dos pacientes. Apesar de serem provenientes de famílias de baixa renda, a maioria dos pacientes teve acesso ao tratamento recomendado. CONCLUSÃO: Entre pacientes com T1DM, 71% tinham escores IQVJD compatíveis com melhor HRQOL.

SUMMARY Health-related quality of life (HRQOL) in type 1 diabetes mellitus (T1DM) has been widely studied. The objectives of this study were to evaluate and identify the factors influencing the HRQOL of children and adolescents with T1DM. MATERIAL AND METHODS: In total, 59 patients (9–16 years, T1DM for ≥1 year) responded to a version of the Diabetes Quality of Life Instrument for Youth (DQOLY) adapted to adapted to Brazilian patients, the Instrumento de Qualidade de Vida para Jovens com Diabetes (IQVJD). This instrument comprises 50 items (domains satisfaction, impact, and concerns, with the lowest scores corresponding to better HRQOL) and a questionnaire gathering social, demographic, and clinical parameters. RESULTS: The mean age of the patients was 13.6 years, and 57.6% were girls. The median age at diagnosis was 7.16 years, 63% presented diabetic ketoacidosis (DKA) at diagnosis and 29% during follow-up. Mean glycated hemoglobin (HbA1c) in the previous year was 10%. All patients administered multiple insulin doses (mean 4.2 applications/day), 74.5% used rapid-acting and intermediate-acting insulin analogs, and 67.8% used pens for insulin application. The results of the DQOLY were within the cutoff limit for better HRQOL. An isolated analysis of each domain and the questionnaire results showed that the following factors were associated with better HRQOL: height Z-score, lower HbA1c, practice of physical activity, use of pen, fewer hospitalizations, and residence in a rural area. There was a high DKA rate at diagnosis, and the metabolic control was inappropriate in most patients. Despite coming from low-income households, most patients had access to the recommended treatment. CONCLUSION: Among T1DM patients, 71% had IQVJD scores compatible with better HRQOL.