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1.
Diversity of phytophagous stink bugs (Hemiptera: Pentatomidae) associated with rice crop in Itapecuru-Mirim, Maranhão, Brazil
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Lima, Matheus Henrique Felipe
; Melo Neto, Antônio Jacinto de
; Pereira, Francisco Antônio de Souza
; Rocha Cardoso, Pedro Livio Enes
; Santiago, Carlos Martins
; Barbosa Abreu, Guilherme
; Rodrigues de Souza, Joseane
.
Resumen Dentro de la diversidad de chinches fitófagos encontrados en campos de arroz en Itapecuru-Mirim, Maranhão, tenemos el primer registro de Edessa meditabunda en el cultivo y el segundo registro en Brasil de Paratibraca dubia. Además, se observaron Tibraca limbativentris, Oebalus poecilus y Oebalus ypsilongriseus.
Abstract From the diversity of phytophagous stink bugs found in rice fields in Itapecuru-Mirim, Maranhão, we have the first record of Edessa meditabunda in the crop, and the second record in Brazil of Paratibraca dubia. Additionally, Tibraca limbativentris, Oebalus poecilus, and Oebalus ypsilongriseus were observed.
2.
Individual and contextual factors associated with the survival of patients with severe acute respiratory syndrome by COVID-19 in Brazil
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Martins Neto, Carlos
; Silva, Fábio Nogueira da
; Dias Júnior, José de Jesus
; Branco, Maria dos Remédios Freitas Carvalho
; Santos, Alcione Miranda dos
; Oliveira, Bruno Luciano Carneiro Alves de
.
RESUMO Objetivo: Analisar a influência dos fatores individuais e contextuais do hospital e do município de assistência sobre a sobrevida de pacientes com Síndrome Respiratória Aguda Grave por COVID-19. Métodos: Estudo de coorte hospitalar com dados de 159.948 adultos e idosos com Síndrome Respiratória Aguda Grave por COVID-19 internados de 01 de janeiro a 31 de dezembro de 2022 e notificados no Sistema de Informação de Vigilância Epidemiológica da Influenza. As variáveis contextuais foram relacionadas à estrutura, aos profissionais e equipamentos dos estabelecimentos hospitalares e indicadores socioeconômicos e de saúde dos municípios. O desfecho foi a sobrevida hospitalar em até 90 dias. Árvore de sobrevida e curvas de Kaplan-Meier foram utilizados para analisar a sobrevida. Resultados: A letalidade hospitalar foi de 30,4%. Idosos submetidos à ventilação mecânica invasiva e internados em cidades com baixo percentual de arrecadação de impostos apresentaram menor sobrevida quando comparados aos demais grupos identificados na árvore de sobrevida (p<0,001). Conclusão: O estudo indicou a interação de fatores contextuais com os individuais, e evidencia que características hospitalares e dos municípios aumentam o risco de óbito, destacando a atenção à organização, ao funcionamento e desempenho da rede hospitalar.
ABSTRACT Objective: To analyze the influence of individual and contextual factors of the hospital and the municipality of care on the survival of patients with Severe Acute Respiratory Syndrome due to COVID-19. Methods: Hospital cohort study with data from 159,948 adults and elderly with Severe Acute Respiratory Syndrome due to COVID-19 hospitalized from January 1 to December 31, 2022 and reported in the Influenza Epidemiological Surveillance Information System. The contextual variables were related to the structure, professionals and equipment of the hospital establishments and socioeconomic and health indicators of the municipalities. The outcome was hospital survival up to 90 days. Survival tree and Kaplan-Meier curves were used for survival analysis. Results: Hospital lethality was 30.4%. Elderly patients who underwent invasive mechanical ventilation and were hospitalized in cities with low tax collection rates had lower survival rates compared to other groups identified in the survival tree (p<0.001). Conclusion: The study indicated the interaction of contextual factors with the individual ones, and it shows that hospital and municipal characteristics increase the risk of death, highlighting the attention to the organization, operation, and performance of the hospital network.
3.
Use of insect repellent as personal protection among women of childbearing age in an arbovirus endemic area in Northeastern Brazil
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Dias, Livia Karla Sales
; Sanhueza-Sanzana, Carlos
; Pinheiro Júnior, Francisco Marto Leal
; Martins, Adriano Ferreira
; Correia, Francisco Gustavo Silveira
; de Aguiar, Italo Wesley Oliveira
; Ferreira, Nayane Cavalcante
; Stolow, Jeni
; Rutherford, George
; Teixeira, Maria Gloria
; Pires Neto, Roberto da Justa
; de Almeida, Rosa Livia Freitas
; Coelho, Ivo Castelo Branco
; Frota, Cristiane Cunha
; Kendall, Carl
; Kerr, Ligia Regina Franco Sansigolo
.
ABSTRACT Objective: To analyze the factors associated with the individual use of insect repellent by women of childbearing age living in area endemic for arboviruses in Fortaleza, Brazil. Methods: This is a cohort study carried out between 2018 and 2019 with women aged between 15 and 39 years in Fortaleza, state of Ceará, Brazil. A total of 1,173 women users of one of the four selected primary health care units participated in the study. The outcome was divided into: continued use, discontinued use, and nonuse of insect repellent. Crude and adjusted multinominal logistic regression analysis was carried out guided by a hierarchical model, with presentation of the respective odds ratio (OR) and 95% confidence intervals (95%CI). The independent variables include: socioeconomic and demographic data, environmental and sanitary characteristics, knowledge of the insect repellent, and behavioral and pregnancy-related aspects. Results: Only 28% of the participants reported using insect repellent during the two waves of the cohort. Women with higher education (OR=2.55; 95%CI 1.44–4.51); who are employed (OR=1.51; 95%CI 1.12–2.03); who received guidance from healthcare professionals (OR=1.74; 95%CI 1.28–2.36) and the media (OR=1.43; 95%CI 1.01–2.02); who intensified precautions against mosquitoes during the epidemic (OR=3.64; 95%CI 2.29–5.78); and who were pregnant between 2016 and 2019 (OR=2.80; 95%CI 1.83–4.30) had increased odds for continued use of insect repellent. Conclusion: The use of insect repellent among women of childbearing age was associated with a higher level of education, employment, guidance on insect repellent provided by healthcare professionals and the media, behavioral changes to protect against mosquitoes during the Zika virus epidemic, and pregnancy when occurring as of the beginning of the epidemic period.
RESUMO Objetivo: Analisar os fatores associados ao uso de repelente individual por mulheres em idade fértil residentes em área endêmicas para arboviroses em Fortaleza, Brasil. Métodos: Coorte realizada entre 2018 e 2019, com mulheres entre 15 e 39 anos, moradoras em Fortaleza, Ceará, Brasil. Participaram 1.173 mulheres, usuárias de quatro unidades primárias de saúde do município. O desfecho foi categorizado em: uso continuado, uso descontinuado e não uso de repelente. Realizada análise de regressão logística multinominal norteada por modelo hierárquico, com apresentação dos respectivos odds ratio (OR) e intervalos de confiança de 95% (IC95%). As variáveis independentes incluem: dados socioeconômicos e demográficos, características ambientais e sanitárias, conhecimento sobre o repelente e aspectos comportamentais e relacionados à gravidez. Resultados: Somente 28% das participantes referiram o uso de repelente durante as duas ondas da coorte. Mulheres com escolaridade superior (OR=2,55; IC95% 1,44–4,51); com emprego (OR=1,51; IC95% 1,12–2,03); que receberam orientações por profissionais da saúde (OR=1,74; IC95% 1,28–2,36) e pela mídia (OR=1,43; IC95% 1,01–2,02); que intensificaram os cuidados contra o mosquito na epidemia (OR=3,64; IC95% 2,29–5,78); estavam grávidas entre 2016 e 2019 (OR=2,80; IC95% 1,83–4,30) tiveram as chances aumentadas para uso continuado de repelente. Conclusões: O uso de repelente entre mulheres em idade fértil mostrou-se associado a um maior nível de escolaridade, ao emprego, às orientações sobre repelente fornecidas por profissionais de saúde e pela mídia, às mudanças comportamentais de cuidado contra o mosquito durante a epidemia da Zika e à gravidez quando ocorrida a partir do início do período epidêmico.
4.
Identification of rice mutant families with chilling tolerance
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Getz, Barbara
; Silva, Raíssa Martins da
; Luz, Viviane Kopp da
; Sousa, Rogerio Oliveira de
; Magalhães Júnior, Ariano Martins de
; Barbosa Neto, José Fernandes
; Maia, Luciano Carlos da
; Oliveira, Antonio Costa de
.
Resumo O objetivo deste trabalho foi caracterizar a tolerância ao frio em famílias mutantes de arroz na geração M4, no início do estágio vegetativo. Foram realizados dois experimentos. No experimento I, a tolerância ao frio foi avaliada em 43 famílias mutantes, no genótipo original 'BRS Querência' e em 19 genótipos comerciais. No Experimento II, 8 famílias mutantes do Experimento I, 'BRS Querência' e um mutante proveniente da geração M5 foram testados. Em ambos os experimentos, as plântulas foram avaliadas em duas condições: 10°C por sete dias e 25°C por sete dias. No Experimento I, as mutações induzidas em arroz levaram a respostas variadas nas características de tolerância ao frio, com algumas famílias mutantes M4 tendo superado o genótipo original. O Experimento II destacou o impacto das mutações na tolerância ao frio, particularmente em termos de descoloração das folhas e recrescimento da planta. As famílias mutantes no estágio M4 diferem do genótipo original 'BRS Querência' em tolerância ao frio, no início do estágio vegetativo. As famílias mutantes M36, M54 e M56 e 'BRS Querência' apresentam similaridade genética, o que indica falta de tolerância ao frio durante o início do estágio vegetativo. As famílias mutantes M17, M21, M22 e M26 são promissoras para programas de melhoramento genético de arroz, pois apresentam tolerância ao frio. A família mutante M30 apresenta o melhor desempenho em todas as características analisadas, o que indica tolerância ao frio no início do estágio vegetativo. M vegetativo experimentos I 4 BRS Querência 1 comerciais testados condições 10C C 10 25C 25 planta M36 genética M17 M21 M2 M3 analisadas 2 M1
Abstract The objective of this work was to characterize chilling tolerance in rice mutant families of the M4 generation, at the seedling stage. Two experiments were carried out: chilling tolerance was evaluated in 43 mutant families, in the 'BRS Querência' original genotype, and in 19 commercial genotypes. In Experiment II, 8 mutant families from Experiment I, 'BRS Querência', and a mutant of the M5 generation were tested. In both experiments, seedlings were evaluated under two conditions: 10°C for seven days and 25°C for seven days. In Experiment I, the induced mutations in rice led to varied responses in chilling tolerance traits, with some M4 mutant families outperforming the original genotype. Experiment II highlighted the impact of mutations on chilling-tolerance, particularly in terms of leaf discoloration and plant recovery. Mutant families of the M4 generation differ from the original genotype 'BRS Querência' in chilling tolerance at the seedling stage. The mutant families M36, M54, and M56 and 'BRS Querência' show genetic similarity, indicating a lack of chilling tolerance during the seedling stage. The mutant families M17, M21, M22, and M26 are promising for rice breeding programs because they present chilling tolerance. The M30 mutant family exhibits the best performance for all analyzed traits, indicating chilling tolerance at the seedling stage. M stage out 4 BRS Querência 1 genotypes I Querência, , tested conditions 10C C 10 25C 25 traits chillingtolerance, chillingtolerance tolerance, chilling-tolerance recovery M36 M54 similarity M17 M21 M22 M2 M3 2 M1
5.
Evaluation of Meibomian gland dysfunction using meibography in patients with xeroderma pigmentosum
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Marcos, Allexya Affonso Antunes
; Freitas, Denise
; Hazarbassanov, Rossen Mihaylov
; Fernandes, Arthur Gustavo
; Castro, Ligia Pereira
; Melo, Danilo Batista Vieira de
; Menck, Carlos F. Martins
; Morales, Melina Correia
; Gomes, José Álvaro Pereira
; Belfort Neto, Rubens
; Singh, Arun D.
.
ABSTRACT Purpose: To assess Meibomian gland dysfunction using meibography in patients with xeroderma pigmentosum and correlate with ocular surface changes. Methods: This cross-sectional study evaluated patients with xeroderma pigmentosum. All patients underwent a comprehensive and standardized interview. The best-corrected visual acuity of each eye was determined. Detailed ophthalmic examination was conducted, including biomicroscopy examination of the ocular surface, Schirmer test type I, and meibography, and fundus examination was also performed when possible. Meibomian gland dysfunction was assessed by non-contact meibography using Oculus Keratograph® 5M (OCULUS Inc., Arlington, WA, USA). Saliva samples were collected using the Oragene DNA Self-collection kit (DNA Genotek Inc., Ottawa, Canada), and DNA was extracted as recommended by the manufacturer. Factors associated with abnormal meiboscores were assessed using generalized estimating equation models. Results: A total of 42 participants were enrolled, and 27 patients underwent meibography. The meiboscore was abnormal in the upper eyelid in 8 (29.6%) patients and in the lower eyelid in 17 (62.9%). The likelihood of having abnormal meiboscores in the lower eyelid was 16.3 times greater than that in the upper eyelid. In the final multivariate model, age (p=0.001), mutation profile (p=0.006), and presence of ocular surface malignant tumor (OSMT) (p=0.014) remained significant for abnormal meiboscores. For a 1-year increase in age, the likelihood of abnormal meiboscores increased by 12%. Eyes with OSMT were 58.8 times more likely to have abnormal meiboscores than eyes without ocular surface malignant tumor. Conclusion: In the final model, age, xeroderma pigmentosum profile, previous cancer, and clinical alterations on the eyelid correlated with a meiboscore of ≥2. Meibomian gland dysfunction was common in patients with xeroderma pigmentosum, mainly in the lower eyelid. The severity of Meibomian gland dysfunction increases with age and is associated with severe eyelid changes. Purpose changes Methods crosssectional cross sectional interview bestcorrected best corrected determined conducted I possible noncontact non contact Keratograph M OCULUS Inc Inc. Arlington WA USA. USA . USA) Selfcollection Self collection Ottawa Canada, Canada , Canada) manufacturer models Results 4 enrolled 2 29.6% 296 29 6 (29.6% 1 62.9%. 629 62.9% 62 9 (62.9%) 163 16 3 16. model p=0.001, p0001 p p=0.001 0 001 (p=0.001) p=0.006, p0006 p=0.006 006 (p=0.006) (OSMT p=0.014 p0014 014 (p=0.014 1year year 12 12% 588 58 58. Conclusion cancer ≥2 29.6 (29.6 62.9 (62.9% p000 p=0.00 00 (p=0.001 (p=0.006 p=0.01 p001 01 (p=0.01 5 ≥ 29. (29. 62. (62.9 p00 p=0.0 (p=0.00 (p=0.0 (29 (62. p0 p=0. (p=0. (2 (62 p=0 (p=0 ( (6 p= (p= (p
6.
Individual and contextual factors associated with the survival of patients with severe acute respiratory syndrome by COVID-19 in Brazil COVID19 COVID 19 COVID-1 COVID1 1 COVID-
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Martins Neto, Carlos
; Silva, Fábio Nogueira da
; Dias Júnior, José de Jesus
; Branco, Maria dos Remédios Freitas Carvalho
; Santos, Alcione Miranda dos
; Oliveira, Bruno Luciano Carneiro Alves de
.
RESUMO Objetivo: Analisar a influência dos fatores individuais e contextuais do hospital e do município de assistência sobre a sobrevida de pacientes com Síndrome Respiratória Aguda Grave por COVID-19. Métodos: Estudo de coorte hospitalar com dados de 159.948 adultos e idosos com Síndrome Respiratória Aguda Grave por COVID-19 internados de 01 de janeiro a 31 de dezembro de 2022 e notificados no Sistema de Informação de Vigilância Epidemiológica da Influenza. As variáveis contextuais foram relacionadas à estrutura, aos profissionais e equipamentos dos estabelecimentos hospitalares e indicadores socioeconômicos e de saúde dos municípios. O desfecho foi a sobrevida hospitalar em até 90 dias. Árvore de sobrevida e curvas de Kaplan-Meier foram utilizados para analisar a sobrevida. Resultados: A letalidade hospitalar foi de 30,4%. Idosos submetidos à ventilação mecânica invasiva e internados em cidades com baixo percentual de arrecadação de impostos apresentaram menor sobrevida quando comparados aos demais grupos identificados na árvore de sobrevida (p<0,001). Conclusão: O estudo indicou a interação de fatores contextuais com os individuais, e evidencia que características hospitalares e dos municípios aumentam o risco de óbito, destacando a atenção à organização, ao funcionamento e desempenho da rede hospitalar. Objetivo COVID19. COVID19 COVID 19. 19 Métodos 159948 159 948 159.94 COVID-1 0 3 202 Influenza estrutura 9 dias KaplanMeier Kaplan Meier Resultados 304 30 4 30,4% p<0,001. p0001 p p<0,001 . 001 (p<0,001) Conclusão óbito organização COVID1 1 15994 15 94 159.9 COVID- 20 30,4 p000 p<0,00 00 (p<0,001 1599 159. 2 30, p00 p<0,0 (p<0,00 p0 p<0, (p<0,0 p<0 (p<0, p< (p<0 (p< (p
ABSTRACT Objective: To analyze the influence of individual and contextual factors of the hospital and the municipality of care on the survival of patients with Severe Acute Respiratory Syndrome due to COVID-19. Methods: Hospital cohort study with data from 159,948 adults and elderly with Severe Acute Respiratory Syndrome due to COVID-19 hospitalized from January 1 to December 31, 2022 and reported in the Influenza Epidemiological Surveillance Information System. The contextual variables were related to the structure, professionals and equipment of the hospital establishments and socioeconomic and health indicators of the municipalities. The outcome was hospital survival up to 90 days. Survival tree and Kaplan-Meier curves were used for survival analysis. Results: Hospital lethality was 30.4%. Elderly patients who underwent invasive mechanical ventilation and were hospitalized in cities with low tax collection rates had lower survival rates compared to other groups identified in the survival tree (p<0.001). Conclusion: The study indicated the interaction of contextual factors with the individual ones, and it shows that hospital and municipal characteristics increase the risk of death, highlighting the attention to the organization, operation, and performance of the hospital network. Objective COVID19. COVID19 COVID 19. 19 Methods 159948 159 948 159,94 COVID-1 31 202 System structure municipalities 9 days KaplanMeier Kaplan Meier analysis Results 304 30 4 30.4% p<0.001. p0001 p p<0.001 . 0 001 (p<0.001) Conclusion ones death organization operation network COVID1 15994 15 94 159,9 COVID- 3 20 30.4 p000 p<0.00 00 (p<0.001 1599 159, 2 30. p00 p<0.0 (p<0.00 p0 p<0. (p<0.0 p<0 (p<0. p< (p<0 (p< (p
7.
Use of insect repellent as personal protection among women of childbearing age in an arbovirus endemic area in Northeastern Brazil
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Dias, Livia Karla Sales
; Sanhueza-Sanzana, Carlos
; Pinheiro Júnior, Francisco Marto Leal
; Martins, Adriano Ferreira
; Correia, Francisco Gustavo Silveira
; de Aguiar, Italo Wesley Oliveira
; Ferreira, Nayane Cavalcante
; Stolow, Jeni
; Rutherford, George
; Teixeira, Maria Gloria
; Pires Neto, Roberto da Justa
; de Almeida, Rosa Livia Freitas
; Coelho, Ivo Castelo Branco
; Frota, Cristiane Cunha
; Kendall, Carl
; Kerr, Ligia Regina Franco Sansigolo
.
RESUMO Objetivo: Analisar os fatores associados ao uso de repelente individual por mulheres em idade fértil residentes em área endêmicas para arboviroses em Fortaleza, Brasil. Métodos: Coorte realizada entre 2018 e 2019, com mulheres entre 15 e 39 anos, moradoras em Fortaleza, Ceará, Brasil. Participaram 1.173 mulheres, usuárias de quatro unidades primárias de saúde do município. O desfecho foi categorizado em: uso continuado, uso descontinuado e não uso de repelente. Realizada análise de regressão logística multinominal norteada por modelo hierárquico, com apresentação dos respectivos odds ratio (OR) e intervalos de confiança de 95% (IC95%). As variáveis independentes incluem: dados socioeconômicos e demográficos, características ambientais e sanitárias, conhecimento sobre o repelente e aspectos comportamentais e relacionados à gravidez. Resultados: Somente 28% das participantes referiram o uso de repelente durante as duas ondas da coorte. Mulheres com escolaridade superior (OR=2,55; IC95% 1,44–4,51); com emprego (OR=1,51; IC95% 1,12–2,03); que receberam orientações por profissionais da saúde (OR=1,74; IC95% 1,28–2,36) e pela mídia (OR=1,43; IC95% 1,01–2,02); que intensificaram os cuidados contra o mosquito na epidemia (OR=3,64; IC95% 2,29–5,78); estavam grávidas entre 2016 e 2019 (OR=2,80; IC95% 1,83–4,30) tiveram as chances aumentadas para uso continuado de repelente. Conclusões: O uso de repelente entre mulheres em idade fértil mostrou-se associado a um maior nível de escolaridade, ao emprego, às orientações sobre repelente fornecidas por profissionais de saúde e pela mídia, às mudanças comportamentais de cuidado contra o mosquito durante a epidemia da Zika e à gravidez quando ocorrida a partir do início do período epidêmico. Objetivo Fortaleza Brasil Métodos 201 1 3 anos Ceará 1173 173 1.17 município hierárquico OR (OR 95 IC95%. IC95 IC . (IC95%) incluem demográficos sanitárias Resultados 28 coorte OR=2,55 OR255 2 55 (OR=2,55 1,44–4,51 144451 44 4 51 1,44–4,51) OR=1,51 OR151 (OR=1,51 1,12–2,03 112203 12 03 1,12–2,03) OR=1,74 OR174 74 (OR=1,74 1,28–2,36 128236 36 OR=1,43 OR143 43 (OR=1,43 1,01–2,02 101202 01 02 1,01–2,02) OR=3,64 OR364 64 (OR=3,64 2,29–5,78 229578 29 5 78 2,29–5,78) OR=2,80 OR280 80 (OR=2,80 1,83–4,30 183430 83 30 Conclusões mostrouse mostrou se epidêmico 20 117 17 1.1 9 IC9 (IC95% OR=2,5 OR25 (OR=2,5 1,44–4,5 14445 OR=1,5 OR15 (OR=1,5 1,12–2,0 11220 0 OR=1,7 OR17 7 (OR=1,7 1,28–2,3 12823 OR=1,4 OR14 (OR=1,4 1,01–2,0 10120 OR=3,6 OR36 6 (OR=3,6 2,29–5,7 22957 OR=2,8 OR28 8 (OR=2,8 1,83–4,3 18343 11 1. (IC95 OR=2, OR2 (OR=2, 1,44–4, 1444 OR=1, OR1 (OR=1, 1,12–2, 1122 1,28–2, 1282 1,01–2, 1012 OR=3, OR3 (OR=3, 2,29–5, 2295 1,83–4, 1834 (IC9 OR=2 (OR=2 1,44–4 144 OR=1 (OR=1 1,12–2 112 1,28–2 128 1,01–2 101 OR=3 (OR=3 2,29–5 229 1,83–4 183 (IC OR= (OR= 1,44– 14 1,12– 1,28– 1,01– 10 2,29– 22 1,83– 18 1,44 1,12 1,28 1,01 2,29 1,83 1,4 1,1 1,2 1,0 2,2 1,8 1, 2,
ABSTRACT Objective: To analyze the factors associated with the individual use of insect repellent by women of childbearing age living in area endemic for arboviruses in Fortaleza, Brazil. Methods: This is a cohort study carried out between 2018 and 2019 with women aged between 15 and 39 years in Fortaleza, state of Ceará, Brazil. A total of 1,173 women users of one of the four selected primary health care units participated in the study. The outcome was divided into: continued use, discontinued use, and nonuse of insect repellent. Crude and adjusted multinominal logistic regression analysis was carried out guided by a hierarchical model, with presentation of the respective odds ratio (OR) and 95% confidence intervals (95%CI). The independent variables include: socioeconomic and demographic data, environmental and sanitary characteristics, knowledge of the insect repellent, and behavioral and pregnancy-related aspects. Results: Only 28% of the participants reported using insect repellent during the two waves of the cohort. Women with higher education (OR=2.55; 95%CI 1.44–4.51); who are employed (OR=1.51; 95%CI 1.12–2.03); who received guidance from healthcare professionals (OR=1.74; 95%CI 1.28–2.36) and the media (OR=1.43; 95%CI 1.01–2.02); who intensified precautions against mosquitoes during the epidemic (OR=3.64; 95%CI 2.29–5.78); and who were pregnant between 2016 and 2019 (OR=2.80; 95%CI 1.83–4.30) had increased odds for continued use of insect repellent. Conclusion: The use of insect repellent among women of childbearing age was associated with a higher level of education, employment, guidance on insect repellent provided by healthcare professionals and the media, behavioral changes to protect against mosquitoes during the Zika virus epidemic, and pregnancy when occurring as of the beginning of the epidemic period. Objective Fortaleza Brazil Methods 201 1 3 Ceará 1173 173 1,17 into model OR (OR 95 95%CI. 95CI CI . (95%CI) include data characteristics pregnancyrelated related aspects Results 28 OR=2.55 OR255 2 55 (OR=2.55 1.44–4.51 144451 44 4 51 1.44–4.51) OR=1.51 OR151 (OR=1.51 1.12–2.03 112203 12 03 1.12–2.03) OR=1.74 OR174 74 (OR=1.74 1.28–2.36 128236 36 OR=1.43 OR143 43 (OR=1.43 1.01–2.02 101202 01 02 1.01–2.02) OR=3.64 OR364 64 (OR=3.64 2.29–5.78 229578 29 5 78 2.29–5.78) OR=2.80 OR280 80 (OR=2.80 1.83–4.30 183430 83 30 Conclusion employment period 20 117 17 1,1 9 (95%CI OR=2.5 OR25 (OR=2.5 1.44–4.5 14445 OR=1.5 OR15 (OR=1.5 1.12–2.0 11220 0 OR=1.7 OR17 7 (OR=1.7 1.28–2.3 12823 OR=1.4 OR14 (OR=1.4 1.01–2.0 10120 OR=3.6 OR36 6 (OR=3.6 2.29–5.7 22957 OR=2.8 OR28 8 (OR=2.8 1.83–4.3 18343 11 1, OR=2. OR2 (OR=2. 1.44–4. 1444 OR=1. OR1 (OR=1. 1.12–2. 1122 1.28–2. 1282 1.01–2. 1012 OR=3. OR3 (OR=3. 2.29–5. 2295 1.83–4. 1834 OR=2 (OR=2 1.44–4 144 OR=1 (OR=1 1.12–2 112 1.28–2 128 1.01–2 101 OR=3 (OR=3 2.29–5 229 1.83–4 183 OR= (OR= 1.44– 14 1.12– 1.28– 1.01– 10 2.29– 22 1.83– 18 1.44 1.12 1.28 1.01 2.29 1.83 1.4 1.1 1.2 1.0 2.2 1.8 1. 2.
8.
Diretriz sobre Diagnóstico e Tratamento da Cardiomiopatia Hipertrófica – 2024 202 20 2
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Fernandes, Fabio
; Simões, Marcus V.
; Correia, Edileide de Barros
; Marcondes-Braga, Fabiana Goulart
; Coelho-Filho, Otavio Rizzi
; Mesquita, Cláudio Tinoco
; Mathias Junior, Wilson
; Antunes, Murillo de Oliveira
; Arteaga-Fernández, Edmundo
; Rochitte, Carlos Eduardo
; Ramires, Felix José Alvarez
; Alves, Silvia Marinho Martins
; Montera, Marcelo Westerlund
; Lopes, Renato Delascio
; Oliveira Junior, Mucio Tavares de
; Scolari, Fernando Luis
; Avila, Walkiria Samuel
; Canesin, Manoel Fernandes
; Bocchi, Edimar Alcides
; Bacal, Fernando
; Moura, Lidia Zytynski
; Saad, Eduardo Benchimol
; Scanavacca, Mauricio Ibrahim
; Valdigem, Bruno Pereira
; Cano, Manuel Nicolas
; Abizaid, Alexandre Antonio Cunha
; Ribeiro, Henrique Barbosa
; Lemos Neto, Pedro Alves
; Ribeiro, Gustavo Calado de Aguiar
; Jatene, Fabio Biscegli
; Dias, Ricardo Ribeiro
; Beck-da-Silva, Luis
; Rohde, Luis Eduardo Paim
; Bittencourt, Marcelo Imbroinise
; Pereira, Alexandre da Costa
; Krieger, José Eduardo
; Villacorta Junior, Humberto
; Martins, Wolney de Andrade
; Figueiredo Neto, José Albuquerque de
; Cardoso, Juliano Novaes
; Pastore, Carlos Alberto
; Jatene, Ieda Biscegli
; Tanaka, Ana Cristina Sayuri
; Hotta, Viviane Tiemi
; Romano, Minna Moreira Dias
; Albuquerque, Denilson Campos de
; Mourilhe-Rocha, Ricardo
; Hajjar, Ludhmila Abrahão
; Brito Junior, Fabio Sandoli de
; Caramelli, Bruno
; Calderaro, Daniela
; Farsky, Pedro Silvio
; Colafranceschi, Alexandre Siciliano
; Pinto, Ibraim Masciarelli Francisco
; Vieira, Marcelo Luiz Campos
; Danzmann, Luiz Claudio
; Barberato, Silvio Henrique
; Mady, Charles
; Martinelli Filho, Martino
; Torbey, Ana Flavia Malheiros
; Schwartzmann, Pedro Vellosa
; Macedo, Ariane Vieira Scarlatelli
; Ferreira, Silvia Moreira Ayub
; Schmidt, Andre
; Melo, Marcelo Dantas Tavares de
; Lima Filho, Moysés Oliveira
; Sposito, Andrei C.
; Brito, Flávio de Souza
; Biolo, Andreia
; Madrini Junior, Vagner
; Rizk, Stephanie Itala
; Mesquita, Evandro Tinoco
.
9.
Catálogo Taxonômico da Fauna do Brasil: Setting the baseline knowledge on the animal diversity in Brazil Brasil
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Boeger, Walter A.
; Valim, Michel P.
; Zaher, Hussam
; Rafael, José A.
; Forzza, Rafaela C.
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; Serejo, Cristiana S.
; Garraffoni, André R.S.
; Santos, Adalberto J.
; Slipinski, Adam
; Linzmeier, Adelita M.
; Calor, Adolfo R.
; Garda, Adrian A.
; Kury, Adriano B.
; Fernandes, Agatha C.S.
; Agudo-Padrón, Aisur I.
; Akama, Alberto
; Silva Neto, Alberto M. da
; Burbano, Alejandro L.
; Menezes, Aleksandra
; Pereira-Colavite, Alessandre
; Anichtchenko, Alexander
; Lees, Alexander C.
; Bezerra, Alexandra M.R.
; Domahovski, Alexandre C.
; Pimenta, Alexandre D.
; Aleixo, Alexandre L.P.
; Marceniuk, Alexandre P.
; Paula, Alexandre S. de
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; Specht, Alexandre
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; Newton, Alfred F.
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; Santos, Aline B. dos
; Tassi, Aline D.
; Aragão, Allan C.
; Santos, Allan P.M.
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; Mendes, Amanda C.
; Cunha, Amanda
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; Almeida, Ana C.S.
; Peronti, Ana L.B.G.
; Henriques-Oliveira, Ana L.
; Prudente, Ana L.
; Tourinho, Ana L.
; Pes, Ana M.O.
; Carmignotto, Ana P.
; Wengrat, Ana P.G. da Silva
; Dornellas, Ana P.S.
; Molin, Anamaria Dal
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; Martins, André L.
; Esteves, André M.
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; Köhler, Andreas
; Paladini, Andressa
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; Lofego, Antônio C.
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; Henriques, Augusto L.
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; Barros, Ávyla R. de A.
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; Romera, Bárbara L.V.
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; Nishiyama, Eric Y.
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; Gallardo, Fabiana
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; Mantellato, Fernando
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; Passos, Flávio D.
; Shockley, Floyd W.
; Pinheiro, Francielly F.
; Mello, Francisco de A.G. de
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; Salles, Frederico F.
; Biffi, Gabriel
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; Hrycyna, Gabriela
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; Powell, Gareth S.
; Santos, Geane B. dos
; Morse, Geoffrey E.
; Brown, George
; Mattox, George M.T.
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; Miranda, Gil F.G.
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; Lourido, Gilcélia M.
; Neves, Gilmar P.
; Moreira, Gilson R.P.
; Montingelli, Giovanna G.
; Maurício, Giovanni N.
; Marconato, Gláucia
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; Silva, Guilherme L. da
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; Brito, Guilherme R.R.
; Garbino, Guilherme S.T.
; Flores, Gustavo E.
; Graciolli, Gustavo
; Libardi, Gustavo S.
; Proctor, Heather C.
; Gil-Santana, Helcio R.
; Varella, Henrique R.
; Escalona, Hermes E.
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; Rodrigues, Higor D.D.
; Galvão Filho, Hilton de C.
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; Pinto, Hudson A.
; Rainho, Hugo L.
; Miyahira, Igor C.
; Gonçalves, Igor de S.
; Martins, Inês X.
; Cardoso, Irene A.
; Oliveira, Ismael B. de
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; S. Campos-Filho, Ivanklin
; Oliveira, Ivo de S.
; Delabie, Jacques H.C.
; Oliveira, Jader de
; Prando, Jadila S.
; Patton, James L.
; Bitencourt, Jamille de A.
; Silva, Janaina M.
; Santos, Jandir C.
; Arruda, Janine O.
; Valderrama, Jefferson S.
; Dalapicolla, Jeronymo
; Oliveira, Jéssica P.
; Hájek, Jiri
; Morselli, João P.
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; Martin, João P.I.
; Grazia, Jocélia
; McHugh, Joe
; Cherem, Jorge J.
; Farias Júnior, José A.S.
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; Avendaño, Jose M.
; Duarte, José M. Barbanti
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; Pujol-Luz, José R.
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; Teixeira, Joyce A.
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; Alvim, Juliana
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; Segadilha, Juliana L.
; Wingert, Juliana M.
; Barbosa, Julianna F.
; Ferrer, Juliano
; Santos, Juliano F. dos
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; Schoeninger, Karine
; Campião, Karla M.
; Soares, Karla
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; Barão, Kim R.
; Teixeira, Larissa
; Sousa, Laura D. do N.M. de
; Dumas, Leandro L.
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; Rocha, Leonardo S.G.
; Bernardi, Leopoldo F.O.
; Vieira, Letícia M.
; Johann, Liana
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; Carvalho, Thiago R. de
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; Henry, Thomas
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; Colombo, Wesley D.
; Tomaszewska, Wioletta
; Wosiacki, Wolmar B.
; Ovando, Ximena M.C.
; Leite, Yuri L.R.
.
ABSTRACT The limited temporal completeness and taxonomic accuracy of species lists, made available in a traditional manner in scientific publications, has always represented a problem. These lists are invariably limited to a few taxonomic groups and do not represent up-to-date knowledge of all species and classifications. In this context, the Brazilian megadiverse fauna is no exception, and the Catálogo Taxonômico da Fauna do Brasil (CTFB) (http://fauna.jbrj.gov.br/), made public in 2015, represents a database on biodiversity anchored on a list of valid and expertly recognized scientific names of animals in Brazil. The CTFB is updated in near real time by a team of more than 800 specialists. By January 1, 2024, the CTFB compiled 133,691 nominal species, with 125,138 that were considered valid. Most of the valid species were arthropods (82.3%, with more than 102,000 species) and chordates (7.69%, with over 11,000 species). These taxa were followed by a cluster composed of Mollusca (3,567 species), Platyhelminthes (2,292 species), Annelida (1,833 species), and Nematoda (1,447 species). All remaining groups had less than 1,000 species reported in Brazil, with Cnidaria (831 species), Porifera (628 species), Rotifera (606 species), and Bryozoa (520 species) representing those with more than 500 species. Analysis of the CTFB database can facilitate and direct efforts towards the discovery of new species in Brazil, but it is also fundamental in providing the best available list of valid nominal species to users, including those in science, health, conservation efforts, and any initiative involving animals. The importance of the CTFB is evidenced by the elevated number of citations in the scientific literature in diverse areas of biology, law, anthropology, education, forensic science, and veterinary science, among others. publications problem uptodate up date classifications context exception (CTFB http//fauna.jbrj.gov.br/, httpfaunajbrjgovbr http //fauna.jbrj.gov.br/ , jbrj gov br (http://fauna.jbrj.gov.br/) 2015 Brazil 80 specialists 1 2024 133691 133 691 133,69 125138 125 138 125,13 82.3%, 823 82 3 (82.3% 102000 102 000 102,00 7.69%, 769 7 69 (7.69% 11000 11 11,00 . 3,567 3567 567 (3,56 2,292 2292 2 292 (2,29 1,833 1833 833 (1,83 1,447 1447 447 (1,44 1000 1,00 831 (83 628 (62 606 (60 520 (52 50 users science health biology law anthropology education others http//fauna.jbrj.gov.br/ faunajbrjgovbr //fauna.jbrj.gov.br (http://fauna.jbrj.gov.br/ 201 8 202 13369 13 133,6 12513 12 125,1 82.3% (82.3 10200 10 00 102,0 7.69% 76 6 (7.69 1100 11,0 3,56 356 56 (3,5 2,29 229 29 (2,2 1,83 183 83 (1,8 1,44 144 44 (1,4 100 1,0 (8 62 (6 60 52 (5 5 http//fauna.jbrj.gov.br (http://fauna.jbrj.gov.br 20 1336 133, 1251 125, 82.3 (82. 1020 0 102, 7.69 (7.6 110 11, 3,5 35 (3, 2,2 22 (2, 1,8 18 (1, 1,4 14 4 ( 82. (82 7.6 (7. 3, (3 2, (2 (1 7. (7
10.
Brain glucose metabolism and gray matter volume in retired professional soccer players: a cross-sectional [18F]FDG-PET/MRI study players crosssectional cross sectional 18FFDGPET/MRI 18FFDGPETMRI FFDGPETMRI 18F FDG PET/MRI PET MRI F 18FFDGPET FFDGPET PETMRI
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Aranha, Mateus Rozalem
; Coutinho, Artur Martins
; Carneiro, Camila de Godoi
; Pastorello, Bruno Fraccini
; Studart Neto, Adalberto
; Guariglia, Carla Cristina
; Tsunemi, Miriam Harumi
; Moreira, Everton Luis Santos
; Ianof, Jéssica Natuline
; Anghinah, Renato
; Nitrini, Ricardo
; Cerri, Giovanni Guido
; Fortea, Juan
; Buchpiguel, Carlos Alberto
; Leite, Claudia Costa
.
Resumo Antecedentes Jogadores profissionais de futebol estão expostos a impactos cranianos repetitivos e ao risco de desenvolver encefalopatia traumática crônica. Objetivo Avaliar o metabolismo glicolítico cerebral regional (MCCr) e o volume de substância cinzenta (vSC) em jogadores de futebol aposentados (JFAs). Métodos Jogadores de futebol aposentados masculinos e controles pareados por idade e sexo foram incluídos prospectivamente entre 2017 e 2019. Foram realizadas avaliações neurológica e neuropsicológica, ressonância magnética (RM) e [18F]FDG-PET cerebrais (3.0-Tesla PET/RM). As imagens foram analisadas visualmente por um neurorradiologista e um médico nuclear cegos ao grupo de cada participante. O metabolismo glicolítico cerebral regional e o vSC foram avaliados através do programa SPM8. Os grupos foram comparados através de testes estatísticos apropriados disponíveis em SPM8 e R, de acordo com a distribuição e o tipo dos dados. Resultados Dezenove JFAs (mediana [IIQ]: 62 [50–64.5] anos) e 20 controles (60 [48–73] anos) foram incluídos. Os JFAs tiveram pior desempenho no mini-exame do estado mental e nos testes de dígitos, desenho do relógio, fluência verbal e fluência semântica e apresentaram MCCr significativamente reduzido no polo temporal e no giro temporal médio anterior esquerdos. Fluência semântica (animais) apresentou correlação positiva com MCCr no hipocampo direito, no polo temporal esquerdo e no aspecto posterior do giro temporal médio esquerdo. Menor vSC foi observado nas mesmas regiões, porém este achado não sobreviveu à correção para comparações múltiplas. Análise individual do [18F]FDG-PET cerebral revelou sete JFAs com claro hipometabolismo nas faces medial e lateral dos lobos temporais, nos lobos frontais e nas regiões temporoparietais. Os JFAs apresentaram ainda maior prevalência de anormalidades do septo pelúcido. Conclusão Os JFAs apresentam MCCr e vSC reduzidos nos lobos temporais, além de anormalidades do septo pelúcido, achados possivelmente relacionados a impactos cranianos repetitivos. crônica (MCCr (vSC JFAs. . (JFAs) 201 2019 neuropsicológica RM (RM 18FFDGPET FFDGPET 18F FDG PET F 3.0Tesla 30Tesla Tesla 3.0 3 0 PET/RM. PETRM PET/RM PET/RM) participante SPM R dados mediana IIQ [IIQ] 6 50–64.5 50645 50 64 5 [50–64.5 anos 2 60 (6 48–73 4873 48 73 [48–73 miniexame mini exame dígitos relógio esquerdos animais (animais direito múltiplas temporais temporoparietais pelúcido (JFAs 0Tesla 30 3. [IIQ 50–64. 5064 [50–64. ( 48–7 487 4 7 [48–7 50–64 506 [50–64 48– [48– 50–6 [50–6 [48 50– [50– [4 [50 [ [5
Abstract Background Professional soccer athletes are exposed to repetitive head impacts and are at risk of developing chronic traumatic encephalopathy. Objective To evaluate regional brain glucose metabolism (rBGM) and gray matter (GM) volume in retired soccer players (RSPs). Methods Male RSPs and age and sex-matched controls prospectively enrolled between 2017 and 2019 underwent neurological and neuropsychological evaluations, brain MRI and [18F]FDG-PET in a 3.0-Tesla PET/MRI scanner. Visual analysis was performed by a blinded neuroradiologist and a blinded nuclear physician. Regional brain glucose metabolism and GM volume were assessed using SPM8 software. Groups were compared using appropriate statistical tests available at SPM8 and R. Results Nineteen RSPs (median [IQR]: 62 [50–64.5] years old) and 20 controls (60 [48–73] years old) were included. Retired soccer players performed worse on mini-mental state examination, digit span, clock drawing, phonemic and semantic verbal fluency tests, and had reduced rBGM in the left temporal pole (pFDR = 0.008) and the anterior left middle temporal gyrus (pFDR = 0.043). Semantic verbal fluency correlated with rBGM in the right hippocampus, left temporal pole, and posterior left middle temporal gyrus (p ≤ 0.042). Cray matter volume reduction was observed in similar anatomic regions but was less extensive and did not survive correction for multiple comparisons (pFDR ≥ 0.085). Individual [18F]FDG-PET visual analysis revealed seven RSPs with overt hypometabolism in the medial and lateral temporal lobes, frontal lobes, and temporoparietal regions. Retired soccer players had a higher prevalence of septum pellucidum abnormalities on MRI. Conclusion Retired soccer players had reduced rBCM and CM volume in the temporal lobes and septum pellucidum abnormalities, findings possibly related to repetitive head impacts. encephalopathy (rBGM (GM RSPs. . (RSPs) sexmatched sex matched 201 evaluations 18FFDGPET FFDGPET 18F FDG PET F 3.0Tesla 30Tesla Tesla 3.0 3 0 PETMRI scanner physician SPM software R median IQR [IQR] 6 50–64.5 50645 50 64 5 [50–64.5 old 2 60 (6 48–73 4873 48 73 [48–73 included minimental mini mental examination span drawing pFDR 0.008 0008 008 0.043. 0043 0.043 043 0.043) hippocampus p 0.042. 0042 0.042 042 0.042) 0.085. 0085 0.085 085 0.085) (RSPs 0Tesla 30 3. [IQR 50–64. 5064 [50–64. ( 48–7 487 4 7 [48–7 0.00 000 00 004 0.04 04 0.08 08 50–64 506 [50–64 48– [48– 0.0 50–6 [50–6 [48 0. 50– [50– [4 [50 [ [5
11.
Different rotations in the acrylonitrile-butadiene-styrene extrusion process and their influence on fracture and mechanical properties acrylonitrilebutadienestyrene acrylonitrile butadiene styrene
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Neto, José Costa de Macêdo
; Teixeira Junior, Renato Moreira
; Costa, João Carlos Martins da
; Kieling, Antônio Cláudio
; Nascimento, Nayara Reis do
; Bello, Roger Hoel
; Freitas, Bruno Mello de
; Pino, Gilberto Garcia del
.
ABSTRACT ABS resins have wide application in the market, mainly in the manufacture of household appliances, telephones, automotive industry and others, and need to be processed by extrusion for the manufacture of products. The variables used in the process of extrusion of polymers have a direct influence on their mechanical properties. The objective of this study was to evaluate the different speeds of the extruder screw (15, 30, 45 and 60 rpm) on the mechanical properties of raw ABS after the extrusion process. Izod impact resistance and tensile tests, were also performed. The fractures of the samples tested by Izod impact were observed via optical microscopy, scanning electronic microscopy (SEM), and roughness was measured. Calorimetric tests (DSC) and thermogravimetry (TGA), as well as melt flow index (MFI), were also performed. The most significant results were observed for the extruder screw speed of 60 rpm. For the impact test, a reduction in impact energy of approximately 3% was observed, with the same result for tensile resistance. However, an increase in the value of the elastic modulus and the MFI was observed due to the increase in the degree of crystallinity, which was caused by the higher shear of the polymer mass in the screw of the extrusion equipment. Additionally, an atypical case occurred for the ABS polymer in the highest rotation, since it was the polymer that suffered the greatest shear in the polymer chains due to the degradation of the butadiene phase. market appliances telephones others products 15, 15 (15 30 4 6 rpm performed SEM, SEM , (SEM) measured DSC (DSC TGA, TGA (TGA) MFI, (MFI) test 3 However crystallinity equipment Additionally rotation phase 1 (1 (SEM (TGA (MFI (
12.
Burial or cremation? Factors associated with preferences among patients with cancer in Brazil: a cross-sectional study cremation Brazil crosssectional cross sectional
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Paiva, Bianca Sakamoto Ribeiro
; Lourenço, Bruna Minto
; Prata, Henrique Moraes
; Valentino, Talita Caroline de Oliveira
; Oliveira, Marco Antonio de
; Santos Neto, Martins Fideles dos
; Bruera, Eduardo
; Paiva, Carlos Eduardo
.
ABSTRACT BACKGROUND: People living with life-limiting illnesses and their family caregivers consistently emphasize the importance of preparing for imminent death, with planned funerals being a common aspect of this preparation. Few studies have described the funeral rituals or post-mortem preferences of patients with cancer. OBJECTIVE: To evaluate the percentage of patients with cancer who wish to be cremated and to identify the factors associated with this preference. DESIGN AND SETTING: Cross-sectional study conducted at Barretos Cancer Hospital. METHODS: A total of 220 patients with cancer completed a Sociodemographic and Clinical Questionnaire, the Duke University Religiosity Index, and burial or cremation preferences. Binary Logistic Regression was performed to identify independent variables associated with cremation. RESULTS: Of the 220 patients, 25.0% preferred cremation and 71.4% preferred burial. Talks about death with family or close friends in their daily life (odds ratio, OR = 2.89; P = 0.021), patients that answered “other” (unsure, tends not be true and not true) for religious beliefs are what really lie behind my whole approach to life (OR = 20.34; P = 0.005), and education 9 to 11 years (OR = 3.15; P = 0.019) or ≥ 12 years (OR = 3.18; P = 0.024) were associated with cremation preference. CONCLUSION: Most patients with Cancer in Brazil prefer burial after death. Discussions about death, religious beliefs and involvement, and educational level seem to influence the preference for cremation. A deeper understanding of ritual funeral preferences and their associated factors may guide policies, services, and health teams in promoting the quality of dying and death. BACKGROUND lifelimiting limiting preparation postmortem post mortem OBJECTIVE SETTING Crosssectional Cross sectional Hospital METHODS 22 Questionnaire Index RESULTS 250 25 0 25.0 714 71 4 71.4 odds ratio 2.89 289 2 89 0.021, 0021 0.021 , 021 0.021) other “other unsure, unsure (unsure 20.34 2034 20 34 0.005, 0005 0.005 005 0.005) 1 3.15 315 3 15 0.019 0019 019 3.18 318 18 0.024 0024 024 CONCLUSION involvement policies services 25. 7 71. 2.8 28 8 002 0.02 02 20.3 203 000 0.00 00 3.1 31 0.01 001 01 2. 0.0 20. 3. 0.
13.
Role of the NF-kB/parkin/vegfr-1 pathway associated with hypoxic-ischemic insult in germinal matrix samples of newborn infants NFkB/parkin/vegfr1 NFkBparkinvegfr1 NFkBparkinvegfr NF kB/parkin/vegfr 1 kB parkin vegfr NF-kB/parkin/vegfr- hypoxicischemic hypoxic ischemic NFkB vegfr1 NFkB/parkin/vegfr kBparkinvegfr NF-kB/parkin/vegfr
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Ghirelli, Eliane Amaral
; Silva, Felipe Paes Gomes da
; Oricil, Alessandro Gonçalves Gomes
; Paula, Caroline Busatta Vaz de
; Nagashima, Seigo
; Oldenburg Neto, Carlos Frederico
; Storti, Eduardo
; Sakiyama, Fernando Yochiteru Rolim
; Kayano, Rafael Martins
; Sakiyama, Renata Rolim
; Moreira, Vinícius da Silva
; Sotomaior, Vanessa Santos
; Noronha, Lucia de
.
RESUMO Objetivo: Dada a alta atividade proliferativa da matriz germinativa e sua correlação direta com a hipoxemia, é necessário investigar as possíveis vias de regulação molecular para entender a relação clínica existente entre o insulto hipóxico-isquêmico e os biomarcadores NF-kB, AKT -3, Parkina, TRK-C e VEGFR-1. Métodos: Cento e dezoito amostras de matriz germinativa do sistema nervoso central de pacientes que faleceram nos primeiros 28 dias de vida foram submetidas a análise histológica e imuno-histoquímica para identificar a imunoexpressão tecidual desses biomarcadores relacionados a eventos de asfixia, prematuridade e óbito em 24 horas. Resultados: Observou-se uma imunoexpressão tecidual significativamente aumentada de NF-kB, AKT-3 e Parkin na matriz germinativa de prematuros. Além disso, constatou-se uma imunoexpressão tecidual significativamente diminuída de VEGFR-1 e de NF-kB em pacientes que apresentaram asfixia seguida de morte em 24 horas. Conclusões: Os resultados sugerem o envolvimento direto entre o insulto hipóxico-isquêmico e os marcadores NF-kB e VEGFR-1, visto que se observou uma imunoexpressão diminuída destes biomarcadores nos pacientes asfixiados. Além disso, sugere-se que não houve tempo suficiente para que o VEGFR-1 fosse transcrito, traduzido e expresso na superfície da membrana plasmática. Essa temporalidade pode ser observada na relação entre a expressão de NF-kB e o tempo de vida dos indivíduos que morreram em 24 horas, o que sugere que esse fator é essencial para a produção do VEGFR-1 e, portanto, para realizar o efeito remodelador necessário para neovascularizar a região afetada. Objetivo hipoxemia hipóxicoisquêmico hipóxico isquêmico NFkB, NFkB NF kB, kB 3, 3 -3 Parkina TRKC TRK C VEGFR1. VEGFR1 VEGFR 1. 1 Métodos 2 imunohistoquímica imuno histoquímica horas Resultados Observouse Observou AKT3 AKT- prematuros disso constatouse constatou VEGFR- Conclusões VEGFR1, 1, asfixiados sugerese transcrito plasmática portanto afetada -
Abstract Objective: Given the high proliferative activity of germinal matrix and its direct correlation with hypoxemia, it is necessary to investigate the possible molecular regulation pathways, to understand the existing clinical relationship between the hypoxic-ischemic insult and the biomarkers NF-kB, AKT-3, Parkin, TRK-C and VEGFR-1. Methods: A hundred and eighteen germinal matrix samples of the central nervous system of patients who died in the first 28 days of life were submitted to histological and immunohistochemistry analysis to identify the tissue immunoexpression of those biomarkers related to asphyxia, prematurity, and death events within 24h. Results: A significantly increased tissue immunoexpression of NF-kB, AKT-3 and Parkin was observed in the germinal matrix of preterm infants. In addition, significantly decreased tissue immunoexpression of VEGFR-1 and NF-kB was observed in patients who experienced asphyxia followed by death within 24 hours. Conclusions: The results suggest a direct involvement between the hypoxic-ischemic insult and NF-kB and VEGFR-1 markers since a decreased immunoexpression of these biomarkers was observed in asphyxiated patients. Furthermore, it is suggested that there was not enough time for VEGFR-1 to be transcribed, translated and expressed on the surface of the plasma membrane. This temporality can be observed in the relationship between NF-kB expression and the survival time of individuals who died within 24 hours, suggesting that this factor is essential for the production of VEGFR-1 and, therefore, to carry out the necessary remodeling effect to neovascularize the affected region. Objective hypoxemia pathways hypoxicischemic hypoxic ischemic NFkB, NFkB NF kB, kB AKT3, AKT3 AKT 3, 3 TRKC TRK C VEGFR1. VEGFR1 VEGFR 1. 1 Methods 2 prematurity 24h h Results AKT- infants addition VEGFR- hours Conclusions Furthermore transcribed membrane therefore region
14.
Nascer de cesariana e associação com quociente de inteligência em adolescentes: contribuição do Consórcio de Coortes RPS (Ribeirão Preto, Pelotas e São Luís), Brasil adolescentes Ribeirão Preto Luís, Luís , Luís)
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Lima, Alice Bianca Santana
; Martins Neto, Carlos
; Ferraro, Alexandre Archanjo
; Barbieri, Marco Antonio
; Simões, Vanda Maria Ferreira
.
El objetivo del estudio fue evaluar la asociación entre la cesárea y el cociente de inteligencia (CI) en adolescentes del Municipio de São Luís, Maranhão, Brasil. Este es un estudio longitudinal que utiliza datos de la cohorte de nacimiento en São Luís, que comenzó en 1997. El abordaje ocurrió en la tercera fase de la cohorte, en 2016, con adolescente a los 18 y 19 años de edad. La variable de exposición fue la vía de nacimiento y la variable de resultado fue el CI, medido a partir de la aplicación de la tercera versión de la Escala de Inteligencia para Adultos (WAIS-III). En el análisis de datos se verificó el CI medio según las covariables y se utilizó la regresión lineal multivariada. Para controlar los factores de confusión se elaboró un modelo teórico utilizando el gráfico acíclico dirigido. Las variables de confusión fueron las socioeconómicas en el momento del nacimiento y las variables perinatales. El coeficiente intelectual promedio de los adolescentes fue de 101,4. En el análisis bruto, el CI de los adolescentes nacidos de cesárea fue 5,8 puntos mayor en relación a los nacidos de parto vaginal (IC95%: 3,8; 7,7, p ≤ 0,001), con significancia estadística. En el análisis multivariado, el valor se redujo a 1,9 (IC95%: -0,5; 3,6, p = 0,141), sin significación estadística. El resultado del estudio mostró que la cesárea no está asociada con el coeficiente intelectual de los adolescentes en esta muestra y refleja que las diferencias encontradas pueden explicarse por otros factores, como los aspectos socioeconómicos y perinatales. (CI Luís Maranhão Brasil 1997 2016 1 edad WAISIII. WAISIII WAIS III . (WAIS-III) multivariada dirigido perinatales 1014 101 4 101,4 bruto 58 5 8 5, IC95% IC95 IC (IC95% 3,8 38 3 77 7 7,7 0,001, 0001 0,001 , 0 001 0,001) estadística multivariado 9 1, 0,5 05 -0,5 36 6 3,6 0,141, 0141 0,141 141 0,141) 199 201 (WAIS-III 10 101, IC9 (IC95 3, 7, 000 0,00 00 0, -0, 014 0,14 14 20 (IC9 0,0 -0 01 0,1 2 (IC -
O objetivo do estudo foi avaliar a associação entre a cesariana e o quociente de inteligência (QI) em adolescentes do Município de São Luís, Maranhão, Brasil. Trata-se de um estudo longitudinal utilizando dados da coorte de nascimento em São Luís, iniciado no ano de 1997. A abordagem ocorreu na terceira fase da coorte, em 2016, com adolescente aos 18 e 19 anos de idade. A variável de exposição foi a via de nascimento e a variável de desfecho foi o QI, mensurada a partir da aplicação da terceira versão da Escala de Inteligência Wechsler para Adultos (WAIS-III). Na análise dos dados verificou-se a média do QI segundo as covariáveis e utilizou-se a regressão linear multivariada. Para controlar os fatores de confundimento foi elaborado um modelo teórico utilizando o gráfico acíclico dirigido. As variáveis confundidoras foram as socioeconômicas no momento do nascimento e as variáveis perinatais. A média do QI dos adolescentes foi 101,4. Na análise bruta, o QI dos adolescentes nascidos de cesariana foi 5,8 pontos maior em relação aos nascidos de parto vaginal (IC95%: 3,8; 7,7, p ≤ 0,001), com significância estatística. Na análise multivariada, o valor reduziu para 1,9 (IC95%: -0,5; 3,6, p = 0,141), sem significância estatística. O resultado do estudo mostrou que a cesariana não está associada ao QI dos adolescentes nessa amostra e reflete que as diferenças encontradas podem ser explicadas por outros fatores, como aspectos socioeconômicos e perinatais. (QI Luís Maranhão Brasil Tratase Trata se 1997 2016 1 idade WAISIII. WAISIII WAIS III . (WAIS-III) verificouse verificou utilizouse utilizou multivariada dirigido perinatais 1014 101 4 101,4 bruta 58 5 8 5, IC95% IC95 IC (IC95% 3,8 38 3 77 7 7,7 0,001, 0001 0,001 , 0 001 0,001) estatística 9 1, 0,5 05 -0,5 36 6 3,6 0,141, 0141 0,141 141 0,141) 199 201 (WAIS-III 10 101, IC9 (IC95 3, 7, 000 0,00 00 0, -0, 014 0,14 14 20 (IC9 0,0 -0 01 0,1 2 (IC -
This study aimed to evaluate the association between cesarean section and intelligence quotient (IQ) in adolescents from the Municipality of São Luís, Maranhão State, Brazil. This is a longitudinal study using data from the São Luís birth cohort, started in 1997. The approach occurred in the third phase of the cohort, in 2016, with adolescents aged 18 and 19 years. The exposure variable was mode of delivery and the outcome variable was IQ, measured by applying the third version of the Wechsler Adult Intelligence Scale (WAIS-III). In the data analysis, the average IQ was verified according to the covariates and multivariate linear regression was used. To control confounding factors, a theoretical model was elaborated using the directed acyclic graph. The confounding variables were socioeconomic variables at birth and perinatal variables. Their average IQ was 101.4. In the crude analysis, the IQ of adolescents born by cesarean section was 5.8 points higher than those born by vaginal delivery (95%CI: 3.8; 7.7, p ≤ 0.001), with statistical significance. In the multivariate analysis, the value decreased to 1.9 (95%CI: -0.5; 3.6, p = 0.141), without statistical significance. The result of the study showed that cesarean section is not associated with the IQ of adolescents in this sample and reflects that the differences can be explained by other factors, such as socioeconomic and perinatal aspects. (IQ State Brazil cohort 1997 2016 1 years WAISIII. WAISIII WAIS III . (WAIS-III) analysis used factors graph 1014 101 4 101.4 58 5 8 5. 95%CI 95CI CI 95 (95%CI 3.8 38 3 77 7 7.7 0.001, 0001 0.001 , 0 001 0.001) significance 9 1. 0.5 05 -0.5 36 6 3.6 0.141, 0141 0.141 141 0.141) aspects 199 201 (WAIS-III 10 101. 3. 7. 000 0.00 00 0. -0. 014 0.14 14 20 0.0 -0 01 0.1 2 -
15.
Weight gain in patients starting Dolutegravir-based ART according to baseline CD4 count after 48 weeks of follow up Dolutegravirbased Dolutegravir based CD 4
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ABSTRACT Background: Excessive weight gain is a current concern among People Living with HIV (PLHIV) starting ART. Objectives: To evaluate the weight gain after 48-weeks of ART in naive patients, according with baseline CD4 count. Methods: PLHIV starting 3TC + TDF + DTG with at least 48-weeks of follow up in two AIDS referral centers were stratified by baseline CD4 count (lower or higher than 200 cells/mm3). Data on CD4 count, HIV viral load, weight/Body Mass Index (BMI), lipids and glucose levels were collected at baseline, 24 and 48 weeks of treatment. For analysis purpose, patients were categorized according to their BMI progression. Results: A total of 270 patients were included in the study. Mean CD4 count were 78.3 ± 61.7 and 536.7 ± 273 cells/mm3 for low and high CD4 count groups, respectively (p < 0.001). Baseline BMI was significantly lower in low CD4 group (21.7 vs. 23.6 Kg/m2, p < 0.001). Patients in low CD4 group gained more weight than those in high CD4 group (11.2 ± 8.5 kg vs. 2.2 ± 4.2 Kg, p = 0.004). Overall weight gain was higher in women, regardless group (13.1 ± 7.9 Kg vs. 1.4 ± 3.6 Kg for women and men, respectively, p < 0.001). The proportion of overweight/obesity significantly increased in low CD4 group. Viral suppression rate was high for both groups. At week 48 the overall proportion of overweight/obesity was like that reported for the Brazilian population. Conclusions: Weight gain in the present study indicates a “return to health” phenomenon. Excessive weight gain was more frequent in women. Background (PLHIV Objectives 48weeks CD Methods TC 20 cells/mm3. cellsmm3 cellsmm . cells mm3 mm cells/mm3) load weightBody Body BMI, , (BMI) 2 4 treatment purpose progression Results 27 783 78 3 78. 617 61 7 61. 5367 536 536. cells/mm groups 0.001. 0001 0.001 0 001 0.001) 21.7 217 21 (21. vs 236 23 6 23. Kgm2 Kgm m2 m Kg/m2 11.2 112 11 (11. 85 8 5 8. 22 2. 42 4. 0.004. 0004 0.004 004 0.004) 13.1 131 13 1 (13. 79 9 7. 14 1. 36 3. men overweightobesity overweight obesity population Conclusions return health phenomenon (BMI 53 000 0.00 00 21. (21 Kg/m 11. (11 13. (13 0.0 (2 (1 0. (
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subject | subject (title words, abstract and keywords) |
ab | abstract |
ta | journal short title (e.g. Cad. Saúde Pública) |
journal_title | journal full title (e.g. Cadernos de Saúde Pública) |
la | publication language code (e.g. pt - Portuguese, es - Spanish) |
type | document type |
pid | publication identifier |
publication_year | publication year of publication |
sponsor | sponsor |
aff_country | country code of the author's affiliation |
aff_institution | author affiliation institution |
volume | article volume |
issue | article issue |
elocation | elocation |
doi | DOI number |
issn | journal ISSN |
in | SciELO colection code (e.g. scl - Brasil, col - Colômbia) |
use_license | article usage license code |