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Abstract Background: Real-world, primary data on the treatment of psoriasis are scarce, especially concerning the role of soluble biomarkers as outcome predictors. Objective: The authors evaluated the utility of Th1/Th17 serum cytokines along with clinical characteristics as predictors of drug survival in the treatment of psoriasis. Methods: The authors consecutively included participants with moderate to severe psoriasis who were followed up for 6 years. Baseline interferon-α, tumor necrosis factor-α, and inter-leukin (IL)-2, IL-4, IL-6, IL-10, and IL-17A were measured using a cytometric bead array; clinical data were assessed. The authors calculated hazard ratios (HRs) for drug survival using a Cox proportional hazards model. Results: The authors included 262 patients, most of whom used systemic immunosuppressants or biologics. In the multivariate model, poor quality of life measured by the Dermatology Life Quality Index (HR = 1.04; 95% CI 1.01–1.07; p = 0.012) and elevated baseline IL-6 (HR = 1.99; 95% CI 1.29–3.08; p = 0.002) were associated with treatment interruption. Study limitations: The main limitation of any cohort study is the presence of confounders that could not be detected in clinical evaluation. Conclusions: Poor quality of life and elevated baseline serum IL-6 level predicted treatment interruption in patients with moderate to severe psoriasis. Although IL-6 is not the most important mediator of the inflammatory pathway in the skin environment, it is an interesting biomarker candidate for predicting psoriasis treatment response. Background Realworld, Realworld Real world, world Real-world scarce Objective Th1Th17 ThTh Th1 Th17 Th Th1/Th1 Methods years interferonα, interferonα interferon α, α interferon-α factorα, factorα factor factor-α interleukin inter leukin IL2, IL2 IL 2, 2 (IL)-2 IL4, IL4 4, 4 IL-4 IL6, IL6 6, IL10, IL10 10, 10 IL-10 IL17A ILA 17A A array assessed HRs (HRs model Results 26 biologics HR 1.04 104 1 04 95 1.01–1.07 101107 01 07 0.012 0012 0 012 IL- 1.99 199 99 1.29–3.08 129308 29 3 08 0.002 0002 002 limitations evaluation Conclusions environment response Th1Th1 Th1/Th (IL)- IL1 IL-1 1.0 9 1.01–1.0 10110 0.01 001 1.9 19 1.29–3.0 12930 0.00 000 00 Th1Th (IL) 1. 1.01–1. 1011 0.0 1.29–3. 1293 (IL 1.01–1 101 0. 1.29–3 129 1.01– 1.29– 12 1.01 1.29 1.2

O objetivo deste trabalho foi comparar a lixiviação e o potencial de contaminação de lençóis de água com atrazina, em solos sob manejo de plantio direto (PD) e convencional (PC). Foram realizados experimentos em campo e em colunas com Latossolo Vermelho-Escuro distroférrico, submetido ao manejo PD e PC, em Dourados, MS, Brasil. Os valores de condutividade hidráulica e potencial mátrico, determinados com o permeâmetro de Guelph no PD, demonstram fluxo contínuo de água no solo. A maior condutividade na superfície, associada ao potencial mátrico negativo, demonstrou descontinuidade hidrológica, na comparação das camadas subjacentes, verificada no PC em relação ao PD. No entanto, o PD apresentou deslocamento vertical de atrazina menor que o PC. Os resultados mostraram que as perdas de atrazina por lixiviação ocorreram mais intensamente com as primeiras chuvas, logo após a aplicação do produto. O PD apresentou maior concentração de atrazina em comparação ao PC, tendo reduzido as perdas por lixiviação. Os dados indicam que a tecnologia de plantio direto pode reduzir o impacto ambiental provocado pelos pesticidas.

The aim of this work was to compare leaching and potential groundwater contamination in soil under no-tillage and conventional tillage. This experiment was carried out in field conditions and soil columns, using an Oxisol under no-tillage (NT) and conventional tillage (CT) systems in Dourados, MS, Brazil. The determination of the hydraulic conductivity and matrix flux potential, with the use of a Guelph permeameter in the NT, showed a continue flow of water into the soil. Greater conductivity found in the surface soil, associated with the negative matrix flux potential, showed the discontinued hydraulic conductivity, when comparing subsurface layers, in the CT in relation to NT. However, NT resulted in less vertical displacement of atrazine than CT. The largest atrazine losses by leaching occurred more intensely after the first rainfall that followed the product application. Greater atrazine concentrations were retained in NT soil than in CT soil. This resulted in low levels of leaching from the NT soil, which indicates that no-tillage technology can reduce the environmental impact of pesticides.

Index code	Element
ti	article title
au	author
kw	article keywords
subject	subject (title words, abstract and keywords)
ab	abstract
ta	journal short title (e.g. Cad. Saúde Pública)
journal_title	journal full title (e.g. Cadernos de Saúde Pública)
la	publication language code (e.g. pt - Portuguese, es - Spanish)
type	document type
pid	publication identifier
publication_year	publication year of publication
sponsor	sponsor
aff_country	country code of the author's affiliation
aff_institution	author affiliation institution
volume	article volume
issue	article issue
elocation	elocation
doi	DOI number
issn	journal ISSN
in	SciELO colection code (e.g. scl - Brasil, col - Colômbia)
use_license	article usage license code

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