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Inhaled magnesium versus inhaled salbutamol in rescue treatment for moderate and severe asthma exacerbations in pediatric patients
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Debiazzi, Michelle Siqueira

; Bonatto, Rossano César

; Campos, Fábio Joly

; Martin, Joelma Gonçalves

; Fioretto, José Roberto

; Hansen, Maria Letícia das Neves

; Luz, Arthur Martins de Araújo

; Carvalho, Haroldo Teófilo de

Jornal de Pediatria

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oct 2024, Volume 100 N. 5 Pages 539 - 543

Abstract: En | Text: En | PDF: En

Abstract Objective To compare the effectiveness of inhaled Magnesium Sulfate associated with Salbutamol versus Inhaled Salbutamol alone in patients with moderate and severe asthma exacerbations. Method Clinical, prospective and randomized study with patients between 3 and 14 years of age divided into two groups: one to receive inhaled salbutamol associated with magnesium sulfate (GSM), the other to receive inhaled salbutamol alone (GS). The sample consisted of 40 patients, 20 patients in each group. Severity was classified using the modified Wood-Downes score, with values between 4 and 7 classified as moderate and 8 or more classified as severe. Results Post-inhalation scores decreased both in patients who received salbutamol and magnesium and in those who received salbutamol alone, with no statistically significant difference between the groups. Conclusions Despite the benefits when administered intravenously, inhalation of the drug alone or in combination did not reduce the severity of the exacerbation. exacerbations Clinical 1 groups GSM, GSM , (GSM) GS. GS . (GS) 2 group WoodDownes Wood Downes score Postinhalation Post intravenously exacerbation (GSM (GS

https://doi.org/10.1016/j.jped.2024.03.012

Functional Language in Children from a Public Cochlear Implant Program in a Developing Country
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Silva, Alice Lang

; Roberto, Anderson Claudio

; Ramos, Maithe Antonello

; Alves, Debora Milene Ferreira

; Stumpf, Isadora Martins Silva

; Lacroix, Laura Prolla

; Rosito, Letícia Petersen Schmidt

International Archives of Otorhinolaryngology

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sep 2024, Volume 28 N. 3 Pages 517 - 522

Abstract: En | Text: En | PDF: En

Abstract Introduction The World Health Organization (WHO) estimates that ~ 32 million children worldwide are affected by hearing loss (HL). Cochlear implant is the first-line treatment for severe to profound sensorineural HL. It is considered one of the most successful prostheses developed to date. Objective To evaluate the oral language development of pediatric patients with prelingual deafness implanted in a reference hospital for the treatment of HL in southern Brazil. Methods We conducted a retrospective cohort study with a review of medical records of patients undergoing cochlear implant surgery between January 2009 and December 2018. Language development was assessed by reviewing consultations with speech therapy professionals from the cochlear implant group. Results A total of 152 children were included in the study. The mean age at cochlear implant surgery was of 41 months (standard deviation [SD]: ± 15). The patients were divided into six groups considering the type of language most used in their daily lives. We found that 36% of children use oral language as their primary form of communication. In a subanalysis, we observed that patients with developed or developing oral language had undergone cochlear implant surgery earlier than patients using Brazilian Sign Language (Língua Brasileira de Sinais, LIBRAS, in Portuguese) or those without developed language. Conclusion The cochlear implant is a state-of-the-art technology that enables the re-establishment of the sense of hearing and the development of oral language. However, language development is a complex process known to present a critical period to properly occur. We still see many patients receiving late diagnosis and treatment, which implies a delay and, often, the impossibility of developing oral communication. Level of Evidence Level 3 (cohort study). WHO (WHO . (HL) firstline first line date Brazil 200 2018 group 15 4 standard SD [SD] 15. 15) lives 36 communication subanalysis Língua Sinais LIBRAS Portuguese stateoftheart state art reestablishment re establishment However occur often study) (HL 20 201 1 [SD 2

https://doi.org/10.1055/s-0044-1785205

Moderating effect of social risk on the relationship between biological risk and child development
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Santos, Janaina Araujo Teixeira

; Ayupe, Kênnea Martins Almeida

; Camargos, Ana Cristina Resende

; Medeiros, Naguia Leticia

; Gutierres Filho, Paulo José Barbosa

Ciência & Saúde Coletiva

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aug 2024, Volume 29 N. 8 elocation e18432022

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo O desenvolvimento humano é influenciado pela interação entre fatores biológicos e sociais. Este estudo teve como objetivo verificar o efeito moderador do risco social na relação entre risco biológico e desenvolvimento infantil. Os dados foram coletados em 201 crianças, com idades entre 6 e 72 meses. A variável independente foi medida pelo índice de risco biológico, e a variável moderadora pelo índice de risco social. O desenvolvimento infantil foi avaliado por meio do teste Denver II. Regressão linear, tamanho do efeito e análise de moderação foram utilizados para verificar a relação entre IRB e o desenvolvimento infantil (Denver II) e o efeito moderador do IRS. O IRB associou-se negativamente ao desenvolvimento infantil, a interação entre o IRB e o IRS aumentou a variância explicada no resultado do Denver II para 14%. O IRS também foi um moderador significativo dos domínios Linguagem e Motor Grosso. Esta pesquisa evidenciou que o risco social é um moderador da relação entre risco biológico e desenvolvimento infantil; quanto mais fatores de risco social, mais forte essa relação se torna. Por outro lado, pode-se dizer que alguns fatores sociais favorecem o desenvolvimento infantil, mesmo na presença de fatores de risco biológicos. 20 crianças 7 meses linear associouse associou 14 14% Grosso torna lado podese pode 2 1

Abstract Human development is influenced by the interaction between biological and social factors. This study aimed to verify the moderating effect of social risk on the relationship between biological risk and child development. Data were collected on 201 children, aged 6 to 72 months. The independent variable was measured by the biological risk index, and the moderator variable by the social risk index was assessed by the Denver II test. Linear regression, effect size, and analysis of moderation were used to verify the relationship between BRI and the child development (Denver II), and the moderating effect of the SRI. BRI was negatively associated with child development, the interaction between the BRI and SRI increased the explained variance in the Denver II result to 14%. The SRI was also a significant moderator of the Language and Gross Motor domains. This research evidence that social risk moderates the relationship between biological risk and child development, the more social risk factors, the stronger this relationship becomes. On the other hand, it can be said that some social factors favor child development, even in the presence of biological risk factors. 20 children 7 months test regression size II, , II) 14 14% domains becomes hand 2 1

https://doi.org/10.1590/1413-81232024298.18432022

Chronic neutropenia in childhood: experience of a tertiary center childhood
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Matushita, Letícia

; Valera, Elvis Terci

; Aragon, Davi Casale

; Scridelli, Carlos Alberto

; Roxo-Junior, Persio

; Carvalho, Luciana Martins de

Jornal de Pediatria

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jun 2024, Volume 100 N. 3 Pages 311 - 317

Abstract: En | Text: En | PDF: En

Abstract Objective: To assess the prevalence of chronic neutropenia (CN) and the clinical profile of patients with CN aged up to 18 years, followed in the pediatric hematology, rheumatology, or immunology outpatient clinic of a tertiary medical center from May 1, 2018, to 30 April 2019. Methods: Retrospective observational study carried out by collecting data from the patient’s medical charts. CN was defined as absolute neutrophil count (ANC) below 1.5 × 109/L lasting over three months. Autoimmune neutropenia (AIN) was defined by clinical criteria and an over twofold increase in ANC after glucocorticoid stimulation. AIN was considered secondary when associated with autoimmune or immunoregulatory disorders. Wilcoxon and Fisher’s exact tests were used to compare variables; the significance level was 5 %. Results: A total of 1,039 patients were evaluated; 217 (20 %) presented CN. Twenty-one (2 %) had AIN, classified as primary in 57 % of the cases. The average age at the onset of symptoms was 38.6 months. During follow-up, patients had 4.2 infections on average; frequency was higher among patients with secondary AIN (p = 003). Isolated neutropenia occurred in 43 % of the patients with AIN. Neutropenia resolved in eight (38 %) of the 21 patients with AIN within 19.6 months on average. Eight patients with secondary AIN met the criteria for Inborn Errors of Immunity. Conclusion: AIN prevalence was 2 %. Most cases were first evaluated by a pediatric immunologist or rheumatologist rather than a pediatric hematologist. This study highlights the need for a multidisciplinary approach involving a pediatric immunologist, rheumatologist, and hematologist. Objective (CN 1 years hematology rheumatology 2018 3 2019 Methods patient s charts (ANC 15 1. 109L L 109 (AIN stimulation disorders Fishers Fisher variables Results 1039 039 1,03 20 Twentyone Twenty one ( 386 38 6 38. followup, followup follow up, follow-up 42 4 4. p 003. 003 . 003) (3 196 19 19. Immunity Conclusion hematologist 201 10 103 03 1,0 00 0

https://doi.org/10.1016/j.jped.2023.12.003

Variations of oral anatomy and common oral lesions
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Souza, Paulo Ricardo Martins

; Dupont, Letícia

; Mosena, Gabriela

; Dantas, Manuela Lima

; Bulcão, Lucas Abascal

Anais Brasileiros de Dermatologia

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jan 2024, Volume 99 N. 1 Pages 3 - 18

Abstract: En | Text: En | PDF: En

Abstract Several topics related to the oral cavity are briefly addressed in this article, from anatomical variations that, when recognized, avoid unnecessary investigations, to diseases that affect exclusively the mouth, mucocutaneous diseases, as well as oral manifestations of systemic diseases. A complete clinical examination comprises the examination of the mouth, and this approach facilitates clinical practice, shortening the path to diagnosis in the outpatient clinic as well as with in-hospital patients. The objective of this article is to encourage the examination of the oral cavity as a useful tool in medical practice, helping to recognize diseases in this location. recognized investigations mouth practice inhospital hospital patients location

https://doi.org/10.1016/j.abd.2023.06.001

Artificial insemination timing on pregnancy rate of Holstein cows using an automated activity monitoring
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Marques, Letícia Ribeiro

; Almeida, João Vitor Nogueira de

; Oliveira, Angélica Cabral

; Paim, Tiago do Prado

; Marques, Thaisa Campos

; Leão, Karen Martins

Ciência Rural

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2024, Volume 54 N. 3 elocation e20220557

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO: O objetivo deste estudo foi avaliar a probabilidade de prenhez e fatores associados para dois horários de inseminação artificial (IA), oito ou 10 horas após o alarme de monitoramento automatizado de atividades (AAM), na primeira IA pós-parto em 1.054 vacas leiteiras da raça Holandês. O estro foi sincronizado por protocolos a base de prostaglandina ou estradiol-progesterona. Regressão logística stepwise foi realizada para analisar a probabilidade de prenhez e fatores associados (atividade, intensidade do estro, paridade, saúde no periparto, placenta retida, descarga vaginal pós-parto e estação do ano). As maiores taxas de prenhez foram obtidas em multíparas, inseminadas 10 horas após o alarme do AAM, no outono ou inverno, com pico de atividade elevado e intensidade de estro (P < 0,05). Doenças no periparto, placenta retida e descarga vaginal pós-parto influenciaram negativamente a taxa de prenhez, independentemente da paridade. Assim, a otimização dos modelos de AAM, incluindo medidas rotineiras da fazenda como paridade, histórico de saúde no periparto e condições ambientais, podem favorecer a identificação correta do estro e melhorar o alarme do AAM em relação ao momento ideal para a IA, aumentando o desempenho reprodutivo nas vacas leiteiras. RESUMO , (IA) 1 (AAM) pósparto pós parto 1054 054 1.05 Holandês estradiolprogesterona. estradiolprogesterona estradiol progesterona. progesterona estradiol-progesterona atividade, (atividade paridade ano. ano . ano) multíparas inverno P 0,05. 005 0,05 0 05 0,05) Assim ambientais (IA (AAM 105 1.0 00 0,0 1. 0,

ABSTRACT: This study evaluated the probability of pregnancy and associated factors for two times artificial inseminations (AI), 8 or 10 hours after automated activity monitoring (AAM) alarm on the first postpartum AI of 1,054 Holstein dairy cows. The estrus was synchronized by prostaglandin or estradiol-progesterone program. Stepwise logistic regression was performed to analyze the probability of pregnancy, and associated factors (activity, estrus intensity, parity, peripartum health, retained placenta, postpartum vaginal discharge, and season). The highest pregnancy rates were obtained with multiparous animals, inseminated ten hours after the AAM alarm, in the fall or winter season, with a high activity peak and estrus intensity (P < 0.05). Peripartum diseases, retained placenta, and postpartum vaginal discharge negatively influenced the pregnancy rate, regardless of parity. Thus, the optimization of AAM models by including on-farm measures like parity, peripartum health history, and environmental conditions may favor the correct identification of estrus and improve the AAM alarm regarding the ideal moment for AI, increasing the reproductive performance in dairy cows. ABSTRACT , (AI) 1 (AAM 1054 054 1,05 cows estradiolprogesterone estradiol progesterone program activity, (activity parity placenta season. season . season) animals P 0.05. 005 0.05 0 05 0.05) diseases rate Thus onfarm farm history (AI 105 1,0 00 0.0 1, 0.

https://doi.org/10.1590/0103-8478cr20220557

Association between self-perception of the neighborhood environment and sleep problems in older Brazilian adults: findings from ELSI-Brazil
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Sutil, Daiana Vieira

; Moreira, Bruno de Souza

; Canever, Jaquelini Betta

; Cândido, Letícia Martins

; Danielewicz, Ana Lúcia

; Lima-Costa, Maria Fernanda

; Avelar, Núbia Carelli Pereira de

Cadernos de Saúde Pública

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2024, Volume 40 N. 4 elocation e00141623

Abstract: Es Pt En | Text: Es Pt En | PDF: Es | PDF: Pt | PDF: En

Resumen: Este estudio tuvo como objetivo investigar las asociaciones entre las percepcion del vecindario y los problemas de sueño en ancianos brasileños. Se realizó un estudio transversal con 5.719 ancianos de la comunidad (≥ 60 años) del Estudio Longitudinal de Salud de los Ancianos Brasileños (ELSI-Brasil, 2019-2021). Los desenlaces fueron los siguientes: problemas de sueño autoinformados: mala calidad del sueño, somnolencia diurna, quejas de insomnio primario, dificultad para permanecer dormido y despertarse durante la madrugada. Las variables de exposición fueron las siguientes: preguntas sobre la percepción de los participantes sobre el entorno físico y social del vecindario. En el análisis de datos se utilizó la regresión logística. La basura, la suciedad o el césped alto en las calles y el deseo de cambiar el lugar donde viven se asociaron con mayores probabilidades de tener una mala calidad del sueño. La preocupación por las caídas debido a aceras en mal estado, la preocupación por las dificultades para utilizar los medios de transporte y la preocupación por las dificultades para cruzar la calle se asociaron con mayores probabilidades de sufrir todos los problemas de sueño. El ruido producido por los autobuses y automóviles se asoció con una mayor probabilidad de sufrir algunos problemas de sueño. La percepción del vecindario como un buen lugar para vivir se asoció con menores probabilidades de sufrir somnolencia diurna y quejas de insomnio primario. La confianza en la mayoría de la gente del vecindario y la percepción de que los niños y jóvenes tratan a los adultos con respeto se asociaron con menores probabilidades de sufrir somnolencia diurna, quejas de insomnio primario y despertarse durante la madrugada. Un buen lugar para que los niños jugaran y para que los adolescentes crecieran se asoció con menores probabilidades de sufrir somnolencia diurna. Estos resultados pueden ayudar a los gestores públicos a crear políticas de planificación urbana dirigidas a mejorar los entornos vecinales como forma de promover la salud.

Resumo: Este estudo teve como objetivo investigar associações entre percepções da vizinhança e problemas de sono em idosos brasileiros. Foi realizado um estudo transversal com 5.719 idosos da comunidade (≥ 60 anos) do Estudo Longitudinal da Saúde dos Idosos Brasileiros (ELSI-Brasil, 2019-2021). Os desfechos foram problemas de sono autorreferidos: má qualidade do sono, sonolência diurna, queixas de insônia primária, dificuldade em manter o sono e acordar na madrugada. As variáveis de exposição foram: questões sobre a percepção dos participantes sobre o ambiente físico e social da vizinhança. Regressão logística foi utilizada na análise dos dados. Lixo, sujeira ou grama alta nas ruas e o desejo de mudar de onde mora foram associados a maiores chances de má qualidade do sono. Preocupação em cair devido a calçadas em má condição, preocupação com dificuldades para usar os meios de transporte e preocupação com dificuldades para atravessar a rua foram associadas a maiores chances de todos os problemas de sono. O som/ruído dos ônibus e carros foi associado a maiores chances de alguns problemas de sono. A percepção da vizinhança como um bom lugar para morar foi associado a menores chances de sonolência diurna e queixas de insônia primária. A confiança na maioria das pessoas da vizinhança e a percepção de que crianças e jovens tratam os adultos com respeito foram associados a menores chances de sonolência diurna, queixas de insônia primária e acordar na madrugada. Um bom lugar para as crianças brincarem e para os adolescentes crescerem foi associado a menores chances de sonolência diurna. Esses resultados podem ajudar os gestores públicos na criação de políticas de planejamento urbano voltadas a melhorias nos ambientes da vizinhança como forma de promoção da saúde.

Abstract: This study aimed to investigate associations between neighborhood perception and sleep problems in older Brazilian adults. A cross-sectional study was conducted with 5,719 community-dwelling older adults (≥ 60 years) from the Brazilian Longitudinal Study of Aging (ELSI-Brazil, 2019-2021). The outcomes were self-reported sleep problems: poor sleep quality, daytime sleepiness, primary insomnia complaints, difficulty staying asleep, and waking up at dawn. The exposure variables were questions about the perception of participants about the physical and social environment of the neighborhood. Logistic regression was used in data analysis. Garbage, rubbish, or tall grass on the streets and the desire to move were associated with higher odds of poor sleep quality. Concern about falling due to damaged sidewalks, concern about having difficulties taking transportation, and concern about having difficulties crossing the street were associated with higher odds of all sleep problems. Sound/noise of buses and cars was associated with higher odds of some sleep problems. Perceiving the neighborhood as a good place to live was associated with lower odds of daytime sleepiness and primary insomnia complaints. Trusting most people in the neighborhood and perceiving that kids and younger people treat adults with respect were associated with lower odds of daytime sleepiness, primary insomnia complaints, and waking up at dawn. Being a good place for kids to play and raise teenagers was associated with lower odds of daytime sleepiness. These results can assist public administrators in creating urban planning policies aimed at improving neighborhood environments as a means of health promotion.

https://doi.org/10.1590/0102-311xen141623

Relação entre temperatura do ar e incidência de dengue: estudo de séries temporais em Minas Gerais, Brasil (2010-2019)
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Gomes, João Pedro Medeiros

; Ribas, Igor Magaton

; Valadares, Pedro Augusto Rosa

; Jardim, Lucas Santos

; Nogueira, Mário Círio

; Ferreira, Cássia de Castro Martins

; Watanabe, Aripuanã Sakurada Aranha

; Ferreira, Letícia de Castro Martins

Cadernos de Saúde Pública

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2024, Volume 40 N. 3 elocation e00076723

Abstract: En Es Pt | Text: En Es Pt | PDF: En | PDF: Es | PDF: Pt

https://doi.org/10.1590/0102-311xpt076723

Moderating effect of social risk on the relationship between biological risk and child development
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Santos, Janaina Araujo Teixeira

; Ayupe, Kênnea Martins Almeida

; Camargos, Ana Cristina Resende

; Medeiros, Naguia Leticia

; Gutierres Filho, Paulo José Barbosa

Ciência & Saúde Coletiva

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2024, Volume 29 N. 8 elocation e18432022

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.1590/1413-81232024298.18432022

10.

Prospective, randomized, controlled trial assessing the effects of a driving pressure–limiting strategy for patients with acute respiratory distress syndrome due to community-acquired pneumonia (STAMINA trial): protocol and statistical analysis plan Prospective randomized pressurelimiting pressure limiting communityacquired community acquired STAMINA trial)
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Maia, Israel Silva

; Medrado Jr, Fernando Azevedo

; Tramujas, Lucas

; Tomazini, Bruno Martins

; Oliveira, Júlia Souza

; Sady, Erica Regina Ribeiro

; Barbante, Letícia Galvão

; Nicola, Marina Lazzari

; Gurgel, Rodrigo Magalhães

; Damiani, Lucas Petri

; Negrelli, Karina Leal

; Miranda, Tamiris Abait

; Santucci, Eliana

; Valeis, Nanci

; Laranjeira, Ligia Nasi

; Westphal, Glauco Adrieno

; Fernandes, Ruthy Perotto

; Zandonai, Cássio Luis

; Pincelli, Mariangela Pimentel

; Figueiredo, Rodrigo Cruvinel

; Bustamante, Cíntia Loss Sartori

; Norbin, Luiz Fernando

; Boschi, Emerson

; Lessa, Rafael

; Romano, Marcelo Pereira

; Miura, Mieko Cláudia

; Alencar Filho, Meton Soares de

; Dantas, Vicente Cés de Souza

; Barreto, Priscilla Alves

; Hernandes, Mauro Esteves

; Grion, Cintia Magalhães Carvalho

; Laranjeira, Alexandre Sanches

; Mezzaroba, Ana Luiza

; Bahl, Marina

; Starke, Ana Carolina

; Biondi, Rodrigo Santos

; Dal-Pizzol, Felipe

; Caser, Eliana Bernadete

; Thompson, Marlus Muri

; Padial, Andrea Allegrini

; Veiga, Viviane Cordeiro

; Leite, Rodrigo Thot

; Araújo, Gustavo

; Guimarães, Mário

; Martins, Priscilla de Aquino

; Lacerda, Fábio Holanda

; Hoffmann Filho, Conrado Roberto

; Melro, Livia

; Pacheco, Eduardo

; Ospina-Táscon, Gustavo Adolfo

; Ferreira, Juliana Carvalho

; Freires, Fabricio Jocundo Calado

; Machado, Flávia Ribeiro

; Cavalcanti, Alexandre Biasi

; Zampieri, Fernando Godinho

Critical Care Science

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2024, Volume 36 elocation e20240210en

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Contexto: Em estudos observacionais sobre a síndrome do desconforto respiratório agudo, sugeriu-se que a driving pressure é o principal fator de lesão pulmonar induzida por ventilador e de mortalidade. Não está claro se uma estratégia de limitação da driving pressure pode melhorar os desfechos clínicos. Objetivo: Descrever o protocolo e o plano de análise estatística que serão usados para testar se uma estratégia de limitação da driving pressure envolvendo a titulação da pressão positiva expiratória final de acordo com a melhor complacência respiratória e a redução do volume corrente é superior a uma estratégia padrão envolvendo o uso da tabela de pressão positiva expiratória final baixa do protocolo ARDSNet, em termos de aumento do número de dias sem ventilador em pacientes com síndrome do desconforto respiratório agudo devido à pneumonia adquirida na comunidade. Métodos: O estudo STAMINA (ventilator STrAtegy for coMmunIty acquired pNeumoniA) é randomizado, multicêntrico e aberto e compara uma estratégia de limitação da driving pressure com a tabela de pressão positiva expiratória final baixa do protocolo ARDSnet em pacientes com síndrome do desconforto respiratório agudo moderada a grave devido à pneumonia adquirida na comunidade internados em unidades de terapia intensiva. Esperamos recrutar 500 pacientes de 20 unidades de terapia intensiva brasileiras e duas colombianas. Eles serão randomizados para um grupo da estratégia de limitação da driving pressure ou para um grupo de estratégia padrão usando a tabela de pressão positiva expiratória final baixa do protocolo ARDSnet. No grupo da estratégia de limitação da driving pressure, a pressão positiva expiratória final será titulada de acordo com a melhor complacência do sistema respiratório. Desfechos: O desfecho primário é o número de dias sem ventilador em 28 dias. Os desfechos secundários são a mortalidade hospitalar e na unidade de terapia intensiva e a necessidade de terapias de resgate, como suporte de vida extracorpóreo, manobras de recrutamento e óxido nítrico inalado. Conclusão: O STAMINA foi projetado para fornecer evidências sobre se uma estratégia de limitação da driving pressure é superior à estratégia da tabela de pressão positiva expiratória final baixa do protocolo ARDSnet para aumentar o número de dias sem ventilador em 28 dias em pacientes com síndrome do desconforto respiratório agudo moderada a grave. Aqui, descrevemos a justificativa, o desenho e o status do estudo. Contexto sugeriuse sugeriu clínicos Objetivo ARDSNet Métodos ventilator pNeumoniA randomizado 50 2 colombianas Desfechos resgate extracorpóreo inalado Conclusão Aqui justificativa 5

ABSTRACT Background: Driving pressure has been suggested to be the main driver of ventilator-induced lung injury and mortality in observational studies of acute respiratory distress syndrome. Whether a driving pressure-limiting strategy can improve clinical outcomes is unclear. Objective: To describe the protocol and statistical analysis plan that will be used to test whether a driving pressure-limiting strategy including positive end-expiratory pressure titration according to the best respiratory compliance and reduction in tidal volume is superior to a standard strategy involving the use of the ARDSNet low-positive end-expiratory pressure table in terms of increasing the number of ventilator-free days in patients with acute respiratory distress syndrome due to community-acquired pneumonia. Methods: The ventilator STrAtegy for coMmunIty acquired pNeumoniA (STAMINA) study is a randomized, multicenter, open-label trial that compares a driving pressure-limiting strategy to the ARDSnet low-positive end-expiratory pressure table in patients with moderate-to-severe acute respiratory distress syndrome due to community-acquired pneumonia admitted to intensive care units. We expect to recruit 500 patients from 20 Brazilian and 2 Colombian intensive care units. They will be randomized to a driving pressure-limiting strategy group or to a standard strategy using the ARDSNet low-positive end-expiratory pressure table. In the driving pressure-limiting strategy group, positive end-expiratory pressure will be titrated according to the best respiratory system compliance. Outcomes: The primary outcome is the number of ventilator-free days within 28 days. The secondary outcomes are in-hospital and intensive care unit mortality and the need for rescue therapies such as extracorporeal life support, recruitment maneuvers and inhaled nitric oxide. Conclusion: STAMINA is designed to provide evidence on whether a driving pressure-limiting strategy is superior to the ARDSNet low-positive end-expiratory pressure table strategy for increasing the number of ventilator-free days within 28 days in patients with moderate-to-severe acute respiratory distress syndrome. Here, we describe the rationale, design and status of the trial. Background ventilatorinduced induced pressurelimiting limiting unclear Objective endexpiratory end expiratory lowpositive low ventilatorfree free communityacquired community Methods (STAMINA multicenter openlabel open label moderatetosevere moderate severe units 50 Outcomes inhospital hospital support oxide Conclusion Here rationale 5

https://doi.org/10.62675/2965-2774.20240210-en

11.

Relação entre temperatura do ar e incidência de dengue: estudo de séries temporais em Minas Gerais, Brasil (2010-2019) dengue Gerais 20102019 2010 2019 (2010-2019 2010201 201 (2010-201 201020 20 (2010-20 20102 2 (2010-2 (2010- (2010 (201 (20 (2 (
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Gomes, João Pedro Medeiros

; Ribas, Igor Magaton

; Valadares, Pedro Augusto Rosa

; Jardim, Lucas Santos

; Nogueira, Mário Círio

; Ferreira, Cássia de Castro Martins

; Watanabe, Aripuanã Sakurada Aranha

; Ferreira, Letícia de Castro Martins

Cadernos de Saúde Pública

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2024, Volume 40 N. 3 elocation e00076723

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

Resumo A temperatura do ar é um fator climático que afeta a incidência da dengue, com efeitos variando conforme o tempo e o espaço. Investigamos a relação entre a temperatura mínima do ar e a incidência da doença em Minas Gerais, Brasil, e avaliamos a influência de variáveis socioeconômicas e geográficas nessa relação, calculando-se o risco relativo (RR). Este é um estudo de série temporal com análise conduzida em três etapas distintas: modelagem por uso de distributed lag non-linear model (modelos não-lineares distributivos com defasagem), metanálise dos modelos obtidos e metarregressão com dados geográficos e socioeconômicos. A temperatura mínima foi um fator de proteção quando em temperaturas frias extremas (RR = 0,65; IC95%: 0,56-0,76) e moderadas (RR = 0,71; IC95%: 0,64-0,79) e fator de risco em temperaturas de calor moderado (RR = 1,15; IC95%: 1,07-1,24), mas não em extremo (RR = 1,1; IC95%: 0,99-1,22). A heterogeneidade dos modelos foi elevada (I2 = 60%) e essa medida não foi alterada em metarregressão. Temperaturas frias moderadas e extremas causam efeito protetivo, enquanto moderadas quentes aumentam o risco. No entanto, a temperatura mínima do ar não explica nem a variabilidade da região, nem mesmo com as outras variáveis em metarregressão. dengue espaço Gerais Brasil calculandose calculando se RR. RR . (RR) distintas nonlinear non linear nãolineares lineares defasagem, defasagem , defasagem) socioeconômicos 0,65 065 0 65 IC95% IC95 IC 0,560,76 056076 0,56 0,76 56 76 0,56-0,76 0,71 071 71 0,640,79 064079 0,64 0,79 64 79 0,64-0,79 1,15 115 1 15 1,071,24, 107124 1,07 1,24 07 24 1,07-1,24) 1,1 11 0,991,22. 099122 0,99 1,22 99 22 0,99-1,22) I2 I (I 60% 60 protetivo entanto região 0,6 06 6 IC9 560 0,560,7 05607 056 0,5 076 0,7 5 7 0,56-0,7 640 0,640,7 06407 064 079 0,64-0,7 1,071,24 10712 107 1,0 124 1,2 2 1,07-1,24 1, 991 0,991,22 09912 099 0,9 122 9 0,99-1,22 0, 0,560, 0560 05 0,56-0, 0,640, 0640 0,64-0, 1,071,2 1071 10 12 1,07-1,2 0,991,2 0991 09 0,99-1,2 0,560 0,56-0 0,640 0,64-0 1,071, 1,07-1, 0,991, 0,99-1, 0,56- 0,64- 1,071 1,07-1 0,991 0,99-1 1,07- 0,99-

Abstract Air temperature is a climatic factor that affects the incidence of dengue, with effects varying according to time and space. We investigated the relationship between minimum air temperature and dengue incidence in Minas Gerais, Brazil, and evaluated the influence of socioeconomic and geographic variables on this relationship. This is a time series study with analysis conducted in three distinct stages: modeling using a distributed lag non-linear model, meta-analysis of models obtained, and meta-regression with geographic and socioeconomic data. Minimum temperature was a protective factor at extreme cold temperatures (RR = 0.65; 95%CI: 0.56-0.76) and moderate cold temperatures (RR = 0.71; 95%CI: 0.64-0.79), and a risk factor at moderate hot temperatures (RR = 1.15; 95%CI: 1.07-1.24), but not at extreme hot temperatures (RR = 1.1; 95%CI: 0.99-1.22). Heterogeneity of the models was high (I2 = 60%), which was also observed in meta-regression. Moderate and extreme cold temperatures have a protective effect, while moderate hot temperatures increase the risk. However, minimum air temperature does not explain the variability in the region, not even with the other variables in meta-regression. space Gerais Brazil stages nonlinear non linear model metaanalysis meta obtained metaregression regression data RR 0.65 065 0 65 95%CI 95CI CI 95 0.560.76 056076 0.56 0.76 56 76 0.56-0.76 0.71 071 71 0.640.79, 064079 0.64 0.79 , 64 79 0.64-0.79) 1.15 115 1 15 1.071.24, 107124 1.07 1.24 07 24 1.07-1.24) 1.1 11 0.991.22. 099122 0.99 1.22 . 99 22 0.99-1.22) I2 I (I 60%, 60 60% 60%) metaregression. regression. effect However region 0.6 06 6 9 560 0.560.7 05607 056 0.5 076 0.7 5 7 0.56-0.7 640 0.640.79 06407 064 079 0.64-0.79 1.071.24 10712 107 1.0 124 1.2 2 1.07-1.24 1. 991 0.991.22 09912 099 0.9 122 0.99-1.22 0. 0.560. 0560 05 0.56-0. 0.640.7 0640 0.64-0.7 1.071.2 1071 10 12 1.07-1.2 0.991.2 0991 09 0.99-1.2 0.560 0.56-0 0.640. 0.64-0. 1.071. 1.07-1. 0.991. 0.99-1. 0.56- 0.640 0.64-0 1.071 1.07-1 0.991 0.99-1 0.64- 1.07- 0.99-

Resumen La temperatura del aire es un factor climático que afecta la incidencia del dengue, con efectos que varían según el tiempo y el territorio. Investigamos la relación entre la temperatura mínima del aire y la incidencia de la enfermedad en Minas Gerais, Brasil, y evaluamos la influencia de variables socioeconómicas y geográficas en esta relación. Se trata de un estudio de serie temporal cuyo análisis se realiza en tres etapas distintas: modelación mediante el uso de distributed lag non-linear model (modelos distributivos no lineales con retraso), metaanálisis de los modelos obtenidos y metarregresión con datos geográficos y socioeconómicos. La temperatura mínima fue un factor de protección ante temperaturas extremadamente frías (RR = 0,65; IC95%: 0,56-0,76) y moderadas (RR = 0,71; IC95%: 0,64-0,79) y factor de riesgo en temperaturas de calor moderado (RR = 1,15; IC95%: 1,07-1,24), pero no en extremo (RR = 1,1; IC95%: 0,99-1,22). La heterogeneidad de los modelos fue alta (I2 = 60%), y esta medida no se modificó en la metarregresión. Las temperaturas frías moderadas y extremas tienen un efecto protector, mientras que las temperaturas moderadamente altas aumentan el riesgo. Sin embargo, la temperatura mínima del aire no explica la variabilidad de la región, ni siquiera con las demás variables en metarregresión. dengue territorio Gerais Brasil distintas nonlinear non linear retraso, retraso , retraso) socioeconómicos RR 0,65 065 0 65 IC95% IC95 IC 0,560,76 056076 0,56 0,76 56 76 0,56-0,76 0,71 071 71 0,640,79 064079 0,64 0,79 64 79 0,64-0,79 1,15 115 1 15 1,071,24, 107124 1,07 1,24 07 24 1,07-1,24) 1,1 11 0,991,22. 099122 0,99 1,22 . 99 22 0,99-1,22) I2 I (I 60%, 60 60% 60%) protector embargo región 0,6 06 6 IC9 560 0,560,7 05607 056 0,5 076 0,7 5 7 0,56-0,7 640 0,640,7 06407 064 079 0,64-0,7 1,071,24 10712 107 1,0 124 1,2 2 1,07-1,24 1, 991 0,991,22 09912 099 0,9 122 9 0,99-1,22 0, 0,560, 0560 05 0,56-0, 0,640, 0640 0,64-0, 1,071,2 1071 10 12 1,07-1,2 0,991,2 0991 09 0,99-1,2 0,560 0,56-0 0,640 0,64-0 1,071, 1,07-1, 0,991, 0,99-1, 0,56- 0,64- 1,071 1,07-1 0,991 0,99-1 1,07- 0,99-

https://doi.org/10.1590/0102-311xpt076723

12.

Gnathostoma infection after ingestion of raw fish is a probable cause of eosinophilic meningitis in the Brazilian Amazon
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Graeff-Teixeira, Carlos

; Pauli, Dayse Souza de

; Zicarelli, Carlos Alexandre Martins

; Pascoal, Vanessa Fey

; Paiva-Novaes, Estefany de Paula

; Chagas, João Pedro Sarcinelli

; Kersanach, Betina Bolina

; Hadad, David Jamil

; Walger-Schultz, Letícia Karolini

Revista da Sociedade Brasileira de Medicina Tropical

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2024, Volume 57 elocation e00801-2024

Abstract: En | Text: En | PDF: En

ABSTRACT We report a case of eosinophilic meningitis associated with the ingestion of raw fish (Cichla sp.) from the Brazilian Amazon, likely caused by Gnathostoma. A 36-year-old male visited Juruena river on a fishing trip. After 50 days, the patient presented with an intense frontal headache. A cerebrospinal fluid examination revealed 63% eosinophilia. Another individual who ingested raw fish developed linear dermatitis on the abdominal wall. Anti-Gnathostoma serum antibodies were detected, and the patient made a full recovery after treatment with corticosteroids and albendazole. To date, autochthonous Gnathostoma spp. infections in Latin American countries have only caused linear panniculitis. This report raises awareness of gnathostomiasis-causing meningitis. Cichla sp. sp Amazon 36yearold yearold 36 year old trip 5 days headache 63 eosinophilia wall AntiGnathostoma Anti detected albendazole date spp panniculitis gnathostomiasiscausing gnathostomiasis causing 3 6

https://doi.org/10.1590/0037-8682-0434-2023

13.

Obstacles in combating multidrug resistant tuberculosis in pediatric patients: a scope review patients
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Sobreira, Letícia Baltar

; Freitas, Paula de Souza Silva

; Nascimento, Luciana de Cassia Nunes

; Vieira, Anne Caroline Barbosa Cerqueira

; Sales, Carolina Maia Martins

; Pacheco, Alicia de Oliveira

; Rezende, Lucas Dalvi Armond

Revista Brasileira de Saúde Materno Infantil

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2024, Volume 24 elocation e20230082

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Objetivos: identificar as evidências científicas sobre tuberculose excessivamente resistente e multidroga resistente em pacientes pediátricos. Métodos: trata-se de uma revisão de escopo da literatura, tendo como questão norteadora: “Quais as evidências científicas sobre tuberculose multidroga-resistente (TB-MDR) e tuberculose extensivamente resistente em pacientes pediátricos?” A pesquisa usou os descritores: “tuberculose extensivamente resistente a medicamentos” OR “tuberculose resistente a múltiplos medicamentos” AND “pediatria”. A pesquisa foi realizada de modo duplo-cego nas bases de dados Medical Literature Analysis and Retrieval System Online, Regional Office for the Western Pacific’s Institutional Repository for Information Sharing, Embase/Elsevier e International Clinical Trials Registry Platform, com um corte temporal de 2011 a 2021, sendo a amostra final sintetizada de 18 artigos, nos quais avaliou-se o conteúdo metodológico por meio do nível de evidência. Resultados: os resultados mostraram a escassez de pesquisas de alto nível de evidência relacionadas à TB-MDR em crianças, ausência de posologia adequada das drogas de segunda linha para o público pediátrico e a importância do teste de sensibilidade a drogas para o tratamento dos casos. Conclusões: identificou-se que os obstáculos do tratamento TB-MDR se concentraram na ausência de protocolos detalhados, de dosagens medicamentosas seguras e com menor efeito colateral, e, principalmente, nos determinantes sociais do processo saúde e doença que envolvem a TB-MDR. Objetivos pediátricos Métodos tratase trata literatura norteadora Quais multidrogaresistente TBMDR TB MDR (TB-MDR pediátricos? descritores medicamentos pediatria. pediatria . “pediatria” duplocego duplo cego Online Pacifics Pacific s Sharing EmbaseElsevier Embase Elsevier Platform 201 2021 1 artigos avaliouse avaliou Resultados crianças casos Conclusões identificouse identificou detalhados colateral principalmente TBMDR. MDR. “pediatria 20 202 2

Abstract Objectives: to identify the scientific evidence on excessively resistant and multidrug resistant tuberculosis in pediatric patients. Methods: this is a scope review of the literature, with a guiding question: “What is the scientific evidence on multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis in pediatric patients?”. The research used the descriptors: “extensively drug-resistant tuberculosis” OR “multidrug-resistant tuberculosis” AND “pediatrics”. The research was carried out in a double-blind manner in the following databases of the Medical Literature Analysis and Retrieval System Online, Regional Office for the Western Pacific’s Institutional Repository for Information Sharing, Embase/Elsevier and International Clinical Trials Registry Platform, with a temporal cut-off from 2011 to 2021, sending a final synthesized sample of 18 articles, which evaluated the methodological content through the level of evidence. Results: the results show the lack of research with a high level of evidence related to MDR-TB in children, the lack of adequate dosage of second-line drugs for the pediatric population and the importance of drug sensitivity testing for the cases of treatment Conclusions: it was identified that the obstacles to MDR-TB treatment were concentrated in the lack of detailed protocols, safe drug dosages with a low side effect, and mainly in the social health determinants and disease process involving MDR-TB. Objectives patients Methods literature question What multidrugresistant MDRTB MDR TB (MDR-TB drugresistant . patients?” descriptors pediatrics. pediatrics “pediatrics” doubleblind double blind Online Pacifics Pacific s Sharing EmbaseElsevier Embase Elsevier Platform cutoff cut off 201 2021 1 articles Results children secondline second line Conclusions protocols effect MDRTB. TB. patients? “pediatrics 20 202 2

https://doi.org/10.1590/1806-9304202400000082-en

14.

Language development in children from a public cochlear implant program
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Silva, Alice Lang

; Stumpf, Isadora Martins da Silva

; Lacroix, Laura Prolla

; Alves, Debora Milena Ferreira

; Silveira, Adriana Laybauer da

; Costa, Sady Selaimen da

; Rosito, Letícia Petersen Schmidt

Brazilian Journal of Otorhinolaryngology

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2024, Volume 90 N. 5 elocation 101458

Abstract: En | Text: En | PDF: En

Abstract Objective To evaluate the rate of loss to follow-up in a cochlear implant program from the public health system in Southern Brazil as well as the characteristics of hearing loss, sociodemographic, sociocultural and the development of oral language in children with prelingual deafness. Methods Retrospective cohort study with children who underwent CI surgery between 2010 and 2020. Data was collected through of interviews and review of medical records. The language development assessment was performed using the MUSS, MAIS and IT-MAIS scales. For the classification of language development, we used as parameters the values (mean ± SD) found in a previous national study. From those values, the Z-score for each patient at each hearing age (time of experience with the cochlear implant) was calculated. Results Of the 225 children implanted between 2010-2020, 129 were included in this study. The rate of loss to follow-up in the program was 42.6%. The mean age at first surgery was 40.5 (±16.9) months, with 77.5% of patients having received a unilateral implant. Language results below the expected for hearing age (<Z-score-1) for the MAIS score were found in 59.7% of the sample, while for the MUSS score the proportion was 62%. Conclusions Most patients had an elevated mean age at cochlear implantation and there was a high rate of loss to follow-up and low attendance to speech and programming sessions. An overall poor language performance was found for this pediatric cochlear implant program from the public health system in Southern Brazil. Level of evidence Level 3 (Non-randomized cohort study). followup follow up sociodemographic deafness 201 2020 records ITMAIS IT scales SD Zscore Z time calculated 22 20102020, 20102020 2020, 2010-2020 12 426 42 6 42.6% 405 40 5 40. ±16.9 169 16 9 (±16.9 months 775 77 77.5 <Zscore1 Zscore1 <Z 1 (<Z-score-1 597 59 7 59.7 sample 62 62% sessions Nonrandomized Non randomized . study) 20 202 2 2010202 2010-202 4 42.6 ±16. (±16. 77. <Zscore (<Z-score- 59. 201020 2010-20 42. ±16 (±16 (<Z-score 20102 2010-2 ±1 (±1 2010- (± (

https://doi.org/10.1016/j.bjorl.2024.101458

15.

Dimethyl sulfoxide affects the viability and mineralization activity of apical papilla cells in vitro
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Santos, Letícia Martins

; Shimabuko, Danielle Yumi

; Sipert, Carla Renata

Brazilian Dental Journal

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2024, Volume 35 elocation e24-6054

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo O dimetilsulfóxido (DMSO) é amplamente utilizado como adjuvante na dissolução de compostos insolúveis em meio aquoso; no entanto, pode induzir alterações moleculares significativas nas células. Os possíveis danos podem ocorrer obedecendo a um perfil específico do tecido, e o efeito nas células da papila apical humana (hAPC) permanece desconhecido. Portanto, este estudo teve como objetivo avaliar os efeitos do DMSO na viabilidade e atividade de mineralização em culturas de hAPC in vitro e estabelecer padrões de concentrações máximas para seu uso em rotinas laboratoriais. As hAPCs foram cultivadas, plaqueadas e mantidas em meio contendo concentrações crescentes de dimetilsulfóxido (0,1%, 0,5%, 1%, 5% e 10%) por 24 horas, 48 horas, 72 horas e 7 dias. Em cada momento, as células foram submetidas ao ensaio MTT. O ensaio de coloração Alizarin red S foi realizado para avaliar o potencial de mineralização osteo/odontogênica das hAPC expostas ao DMSO (0,1%, 0,5% e 1%) no período de 21 dias. A análise estatística foi realizada por meio de análise de variância unidirecional seguida pelo teste post hoc de Tukey (p<0,05). Em geral, as concentrações de 5% e 10% de DMSO mostraram-se citotóxicas para hAPC em todos os momentos analisados e as hAPC estimuladas por DMSO apresentaram maior potencial de mineralização osteo/odontogênica. Portanto, as concentrações de 5% e 10% de DMSO devem ser evitadas, e os ensaios de atividade de mineralização celular devem ser cuidadosamente elaborados para evitar vieses nos ensaios in vitro utilizando culturas de hAPC. (DMSO aquoso entanto tecido (hAPC desconhecido Portanto laboratoriais cultivadas 0,1%, 01 0 1 (0,1% 05 5 1% 10 2 4 dias momento MTT osteoodontogênica osteo odontogênica 0,5 p<0,05. p005 p p<0,05 . (p<0,05) geral mostraramse mostraram se evitadas 0,1% (0,1 0, p00 p<0,0 (p<0,05 0,1 (0, p0 p<0, (p<0,0 (0 p<0 (p<0, ( p< (p<0 (p< (p

Abstract Dimethyl sulfoxide (DMSO) is widely used as an adjuvant in dissolving insoluble compounds in an aqueous medium; however, it can induce significant molecular changes in cells. The possible damages may occur obeying a tissue-specific profile, and the effect on human apical papilla cells (hAPC) remains unknown. Therefore, this study aimed to evaluate DMSO effects on the viability and mineralization activity in hAPC cultures in vitro and to establish standards of maximum concentrations for its use in laboratory routines. hAPCs were cultured, plated, and maintained in media containing increasing concentrations of Dimethyl sulfoxide (0.1%, 0.5%, 1%, 5%, and 10%) for 24 h, 48 h, 72 h, and 7 days. At each time point, the cells were subjected to the MTT assay. The Alizarin red S staining assay was performed to evaluate the osteo/odontogenic mineralization potential of hAPC DMSO-exposed (0.1%, 0.5%, and 1%) in the 21-day time-point. Statistical analysis was performed using one-way analysis of variance followed by Tukey's post hoc test (p<0.05). In general, the 5% and 10% DMSO concentrations were shown to be cytotoxic for hAPC at all analyzed time points, and the hAPC DMSO-stimulated presented higher osteo/odontogenic mineralization potential. Therefore, the 5% and 10% DMSO concentrations should be avoided, and the mineralization activity assay should be carefully designed in order to avoid biases at in vitro assays using hAPC cultures. (DMSO medium however tissuespecific tissue specific profile (hAPC unknown Therefore routines cultured plated 0.1%, 01 0 1 (0.1% 05 5 0.5% 1% 10 2 h 4 days point osteoodontogenic osteo odontogenic DMSOexposed exposed 21day day 21 timepoint. timepoint point. time-point oneway one way Tukeys Tukey s p<0.05. p005 p p<0.05 . (p<0.05) general points DMSOstimulated stimulated avoided 0.1% (0.1 0.5 p00 p<0.0 (p<0.05 0.1 (0. 0. p0 p<0. (p<0.0 (0 p<0 (p<0. ( p< (p<0 (p< (p

https://doi.org/10.1590/0103-644020246054

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cases of dengue in Brasil in 2015, use:
ti:dengue and publication_year:2015 and aff_country:Brasil

See below the complete list of search indexes that can be used:

Index code	Element
ti	article title
au	author
kw	article keywords
subject	subject (title words, abstract and keywords)
ab	abstract
ta	journal short title (e.g. Cad. Saúde Pública)
journal_title	journal full title (e.g. Cadernos de Saúde Pública)
la	publication language code (e.g. pt - Portuguese, es - Spanish)
type	document type
pid	publication identifier
publication_year	publication year of publication
sponsor	sponsor
aff_country	country code of the author's affiliation
aff_institution	author affiliation institution
volume	article volume
issue	article issue
elocation	elocation
doi	DOI number
issn	journal ISSN
in	SciELO colection code (e.g. scl - Brasil, col - Colômbia)
use_license	article usage license code

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