Abstract This research aims to investigate the syntactic representation of the perfect aspect. More specifically, we intend to verify the morphosyntactic realizations of universal perfect (UP), resultative perfect (ResP) and experiential perfect (ExP) associated to the past and to the indicative mood in Brazilian Portuguese (BP). For this purpose, five hours of spontaneous speech were analyzed and a gap-filling task was applied to 62 native speakers of BP. The results evidenced that UP is conveyed by the imperfective past and the auxiliary verb “estar” (‘to be’) in the imperfective past + gerund; ResP is conveyed by past perfect (with the auxiliary verbs “ter” (‘to have’) and “haver” (‘there to be’), simple past, past perfect simple and “acabar” (‘to finish’) in the past perfect compound with the auxiliary verb “ter” (‘to have’) + ‘de’ (‘of’) + infinitive; and ExP is conveyed by the past perfect compound with the auxiliary verbs “ter” (‘to have’) and “haver” (‘there to be’), simple past and past perfect simple. We discussed that the results corroborate Rodrigues and Martins’s (2019) proposal that there are three perfect phrases in the syntactic tree: Universal Perfect Phrase (UPerfP) to UP, Resultative Perfect Phrase (ResPerfP) to ResP, and Experiential Perfect Phrase (ExPerfP) to ExP.

Resumo Objetiva-se, nesta pesquisa, investigar a representação sintática do aspecto perfect. Mais especificamente, pretende-se verificar as realizações morfossintáticas de perfect universal (PU), resultativo (PRes) e experiencial (PEx) associados ao tempo passado e ao modo indicativo no português brasileiro (PB). Para tanto, foram analisadas cinco horas de fala espontânea e foi aplicado um teste de preenchimento de lacunas a 62 falantes nativos do PB. Os resultados evidenciam que o PU é veiculado por meio de pretérito imperfeito e “estar” no pretérito imperfeito + gerúndio; o PRes é veiculado por meio de pretérito mais-que-perfeito composto (com auxiliares “ter” e “haver”), pretérito perfeito, pretérito mais-que-perfeito simples e “acabar” no pretérito mais-que-perfeito composto com auxiliar “ter” + preposição “de” + infinitivo; e o PEx é veiculado por meio de pretérito mais-que-perfeito composto (com auxiliares “ter” e “haver”), pretérito perfeito e pretérito mais-que-perfeito simples. Os resultados corroboram a proposta de Rodrigues e Martins (2019) de que há três sintagmas de perfect na árvore sintática: o Sintagma de Perfect Universal (UPerfP) para o PU, o Sintagma de Perfect Resultativo (ResPerfP) para o PRes e o Sintagma de Perfect Experiencial (ExPerfP) para o PEx.

ABSTRACT. The objective was to evaluate the effect of probiotic consortium technology (PCT) on the performance of Penaeus vannamei juveniles in the biofloc system in a short time. The experiment had four treatments with four replicates. In each experimental unit, 35 animals (3.15 ± 0.53 g and 7.80 ± 0.54 cm) were stocked in a biofloc system for 35 days. The treatments were: control - control without probiotic; PCT1 - probiotic in the diet (3 mL kg-1) and water (0.5 ppm - three times a week); PCT2 - probiotic in the diet (3 mL kg-1) and water (1 ppm - daily), and PCT3 - probiotic in the water (1 ppm - daily). For water quality and Vibrio, no significant differences were observed among treatments (P > 0.05). Regarding the zootechnical performance, the treatments with the probiotic promoted higher final biomass, biomass gain, and a more efficient feed conversion rate (P < 0.05). The performance improvement promoted by the probiotic may be related to increased concentrations of amylases, chymotrypsin, and lipases in the hepatopancreas (P < 0.05). It was concluded that PCT2 promoted the best zootechnical performance of P. vannamei during the grow-out phase in the biofloc system.

Abstract Background 5-Fluorouracil (5-FU) is a first-line drug to treat cutaneous field cancerization (CFC). There are few clinical trials with topical colchicine (COL). Objective To evaluate the effectiveness of 0.5% COL cream versus 5% 5-FU cream in the treatment of CFC. Method This was a randomized, open, self-controlled clinical trial. Forty-five patients (90 forearms), with three to ten actinic keratoses (AK) on each forearm, used 0.5% COL cream 2×/day for seven days on one forearm, and 5% 5-FU cream 2× /day, for 21 days, on the other forearm. The dosages were defined based on previous clinical trials for each drug. Adverse effects were evaluated after 14 days and outcomes after 90 days of inclusion. The primary outcome was complete AK clearance and the secondary outcomes were: partial clearance (≥50%), reduction in AK count, assessment of the Forearm Photoaging Scale (FPS), AK Severity Score (AKSS), and adverse effects. Results After 90 days, there was complete clearance of AK in 37% (95% CI 24%-49%) and partial clearance in 85% (95% CI 76%-93%) of the forearms treated with 5-FU,versus 17% (95% CI 7%-27%) and 78% (95% CI 66%-88%) for COL (p > 0.07). There was a percentage reduction of 75% in the AK count of the forearms treated with 5-FU (95% CI 66%-83%) and 64% in those treated with COL (95% CI 55%-72%). Regarding FPS and AKSS, there was improvement in both groups, with no difference regarding FPS (p = 0.654), and 5-FU superiority for AKSS (p = 0.012). Study limitations Single-center study. Conclusions 5-FU and COL are effective for treating CFC, with neither showing superiority regarding the reduction in AK counts. 5Fluorouracil Fluorouracil 5 5FU FU (5-FU firstline first line CFC . (CFC) COL. (COL) 05 0 0.5 randomized open selfcontrolled self controlled trial Fortyfive Forty five (9 forearms, , forearms) (AK forearm 2day day 2 /day 1 9 inclusion ≥50%, 50 ≥50% (≥50%) FPS, (FPS) (AKSS) 37 95% 95 (95 24%49% 2449 24% 49% 24 49 24%-49% 85 76%93% 7693 76% 93% 76 93 76%-93% 5FU,versus 5FUversus FUversus FU,versus 17 7%27% 727 7% 27% 7 27 7%-27% 78 66%88% 6688 66% 88% 66 88 66%-88% p 0.07. 007 0.07 07 0.07) 75 66%83% 6683 83% 83 66%-83% 64 55%72%. 5572 55% 72% 55 72 55%-72%) groups 0.654, 0654 0.654 654 0.654) 0.012. 0012 0.012 012 0.012) Singlecenter Single center study counts (CFC (COL 0. ( ≥50 (≥50% (FPS (AKSS 3 24%49 244 4 24%-49 8 76%93 769 76%-93 7%27 7%-27 66%88 668 6 66%-88 00 0.0 66%83 66%-83 55%72% 557 55%-72% 065 0.65 65 001 0.01 01 ≥5 (≥50 24%4 24%-4 76%9 76%-9 7%2 7%-2 66%8 66%-8 55%72 55%-72 06 0.6 ≥ (≥5 24%- 76%- 7%- 66%- 55%7 55%-7 (≥ 55%-

Introduction: Elderly patients have higher rates of morbidity and mortality during hospitalizations, diagnostic and surgical procedures. In order to improve the quality of care for the elderly, the APOIO (Preoperative Assessment of Elderly and Care Guidance) protocol was created, a tool to measure the risks of surgical complications. Objective: To evaluate the impact of APOIO on several outcomes, in order to validate it as a useful vehicle in the prevention of perioperative complications in elderly patients with fractures. Method: Retrospective cross-sectional study through review of 218 medical records of elderly patients hospitalized for fractures, and with surgical indication, having collected data on sex, age, reason for hospitalization, type of fracture, indication or not of surgical treatment, evaluation or not by APOIO, indication or not of ICU in the postoperative period, length of ICU stay, total length of hospitalization, immediate outcome and outcome within 30 days after the operation. Result: It was found that the application of APOIO was associated with a 70% reduction in the chances of death during hospitalization (p=0.040), length of stay in the ICU (p&lt;0.001) and total length of hospital stay (p = 0.010). There was also a trend towards a reduction in the death rate within 30 days of the postoperative period (p = 0.117). Conclusion: The application of the APOIO tool reduces the length of hospitalization, optimizes indication and length of stay in the ICU and, also, reduces the risk of death in elderly people undergoing surgical treatment for fractures.

Introdução: Pacientes idosos apresentam maior morbidade e mortalidade em internamentos hospitalares, procedimentos diagnósticos e cirúrgicos. Buscando melhorar a qualidade assistencial aos idosos foi criado o protocolo APOIO (Avaliação Pré-Operatória de Idosos e Orientação de cuidados), ferramenta para mensurar os riscos de complicações cirúrgicas. Objetivo: Avaliar o impacto do APOIO sobre vários desfechos, a fim de validá-lo como veículo útil na prevenção de complicações perioperatórias em idosos com fraturas. Método: Pesquisa retrospectiva transversal por meio de revisão de 218 prontuários de pacientes idosos internados por fraturas, e com indicação cirúrgica, tendo sido coletados dados sobre sexo, idade, motivo do internamento, tipo de fratura, indicação ou não de tratamento cirúrgico, avaliação ou não pela APOIO, indicação ou não de UTI no pós-operatório, duração do internamento em UTI, duração total do internamento, desfecho imediato e desfecho em 30 dias após a operação. Resultado: Foi constatado que a aplicação do APOIO foi associada à redução de 70% nas chances de óbito durante o internamento (p = 0,040), ao tempo de permanência em UTI (p &lt;0,001) e ao tempo total de internamento hospitalar (p = &nbsp;0,010). Observou-se ainda tendência à redução na taxa de óbitos em 30 dias do pós-operatório (p = 0,117). Conclusão: A aplicação da ferramenta APOIO reduz tempo de internamento, otimiza indicação e tempo de permanência em UTI e ainda diminui o risco de óbito de idosos submetidos a tratamentos cirúrgicos de fraturas.

RESUMO Objetivo: Descrever o primeiro caso conhecido de bertielose humana no Paraná, Brasil. Descrição do caso: Criança de seis anos do sexo masculino, residente no Paraná, Brasil, apresentava dor abdominal inespecífica intermitente e distensão abdominal, associadas à expulsão de helmintos vivos em suas fezes havia sete meses. Tinha um histórico de interação com macacos em uma ilha. Sua primeira análise de fezes foi inconclusiva, com hipótese inicial de uma Taenia atípica. No entanto, após pesquisas adicionais, o parasitologista identificou proglótides gravídicas de Bertiella sp. O paciente foi inicialmente tratado com uma dosagem desconhecida de albendazol e nitazoxanida, pois se acreditava que havia sido infectado por Taenia sp. Diante da persistência dos sintomas, foi prescrito praziquantel 10 mg/kg, sem mais eliminação de proglótides. Comentários: A bertielose humana é uma zoonose rara, com menos de cem casos relatados. No entanto, é uma causa de dor abdominal crônica e deve ser mantida como diagnóstico diferencial, principalmente nos casos que relatam expulsão recorrente de helmintos nas fezes e que são refratários ao tratamento com albendazol. Objetivo Paraná Brasil masculino meses ilha inconclusiva atípica entanto adicionais sp nitazoxanida sintomas 1 mgkg mg kg mg/kg Comentários rara relatados diferencial

ABSTRACT Objective: To describe the first known case of human Bertiellosis in Paraná (Brazil). Case description: A 6-year-old male residing in the Brazilian state of Paraná was suffering from intermittent nonspecific abdominal pain and abdominal distension, associated with expulsion of live tapeworms in his feces for 7 months. He had a history of interaction with monkeys on an island. His first feces analysis was inconclusive, with an initial hypothesis of an atypical Taenia. However, after additional research, the parasitologist identified pregnant proglottids of Bertiella sp. The patient was initially treated with an unknown dosage of albendazole and nitazoxanide, as it was believed he had been infected with Taenia sp. Since the symptoms persisted, praziquantel 10 mg/kg was prescribed without further proglottids elimination. Comments: Human Bertiellosis is a rare zoonosis, with less than one hundred cases reported. However, it is a cause of chronic abdominal pain and should be kept as a differential diagnosis, especially in cases reporting recurrent tapeworm expulsion in feces and refractory treatment with albendazole. Objective Brazil. Brazil . (Brazil) description 6yearold yearold 6 year old distension months island inconclusive However research sp nitazoxanide persisted 1 mgkg mg kg elimination Comments zoonosis reported diagnosis (Brazil

RESUMO Objetivo Identificar evidências científicas sobre o distúrbio de voz relacionado ao trabalho e fatores de risco, além de apontar os sintomas vocais, instrumentos e métodos de avaliação em profissionais da voz falada. Estratégia de pesquisa Revisão integrativa da literatura, realizada nas bases de dados LILACS, SciELO, MEDLINE/PubMed e Scopus. Critérios de seleção Artigos com profissionais da voz falada, que abordassem os fatores de riscos individuais, organizacionais e/ou ambientais vinculados aos sintomas e/ou distúrbios de voz, estudos observacionais, disponíveis na íntegra, sem restrição ao idioma e ano de publicação. Resultados Foram incluídos 58 estudos, maior publicação entre os anos de 2014 e 2022, predominantemente no Brasil, em destaque, o professor. O método de avaliação mais utilizado foi autoavaliação com o uso dos protocolos, seguido da avaliação perceptivo-auditiva e do exame laringológico. Os fatores de risco mais identificados foram os individuais, seguidos dos organizacionais e ambientais, além de terem sido relatados os sintomas vocais sensoriais e auditivos. Conclusão Os fatores mais autorreferidos são ruído, uso intenso da voz, alterações respiratórias, ser do gênero feminino e práticas vocais inadequadas. Quanto aos sintomas vocais sensoriais, destacam-se garganta seca, pigarro e fadiga vocal, e quanto aos auditivos, rouquidão. falada literatura LILACS SciELO MEDLINEPubMed MEDLINE PubMed Scopus individuais eou ou observacionais íntegra 5 201 2022 Brasil destaque professor protocolos perceptivoauditiva perceptivo auditiva laringológico auditivos ruído respiratórias inadequadas destacamse destacam se seca vocal rouquidão 20 202 2

ABSTRACT Purpose To identify scientific evidence about (Work-Related Voice Disorder) and risk factors, as well as to point out vocal symptoms, instruments and evaluation methods in spoken voice professionals. Research strategy Integrative literature review carried out in LILACS, SciELO, MEDLINE/PubMed and Scopus databases. Selection criteria Articles with spoken voice professionals, which addressed individual, organizational and/or environmental risk factors linked to symptoms and/or voice disorders, observational studies, fully available, without restriction to language and year of publication. Results 58 papers were included, the largest publication between the years 2014 and 2022, predominantly in Brazil, with emphasis on the teacher. The most used evaluation method was vocal assessment using self-assessment protocols, followed by auditory-perceptual assessment and laryngological examination. The mostly identified risk factors were individual ones, followed by organizational and environmental ones, in addition to sensory and auditory vocal symptoms having been reported. Conclusion The most often self-reported factors were noise, intense voice use, respiratory changes, being female and inappropriate vocal practices. For sensory vocal symptoms, dry throat, throat clearing and vocal fatigue stand out, and for auditory symptoms, hoarseness. WorkRelated Work Related Disorder professionals LILACS SciELO MEDLINEPubMed MEDLINE PubMed databases andor or disorders studies available 5 included 201 2022 Brazil teacher selfassessment self protocols auditoryperceptual perceptual examination ones reported selfreported noise use changes practices hoarseness 20 202 2

ABSTRACT Objective: To analyze the association of food insecurity (FI) with chronic noncommunicable diseases (NCDs) in the Brazilian context. Methods: The review protocol was registered with the International Prospective Register of Systematic Reviews (PROSPERO). The searches were conducted in LILACS and PubMed databases (September/2022). Observational studies carried out in the Brazilian population published since 2003 were included, in which: (1) the association of FI with NCDs was analyzed; and (2) the Brazilian Food Insecurity Scale was used. Studies on pregnant women and those that associated FI with cancer, sexually transmitted infections, and musculoskeletal and respiratory diseases were excluded. The studies were subjected to methodological quality assessment. Results: A total of 27 cross-sectional studies were included; nine used secondary data from national surveys, and the others used primary data. An association between FI and overweight and obesity in different age groups was verified in the studies. Conclusion: The included articles did not produce evidence on other NCDs of interest to health in Brazil such as diabetes and high blood pressure. However, they corroborate the already-known relationship between obesity and FI. Studies on the topic, with a longitudinal design, should be encouraged.

RESUMO Objetivo: Analisar a associação da insegurança alimentar (IA) com as doenças crônicas não transmissíveis (DCNTs) no contexto brasileiro. Métodos: O protocolo da revisão foi registrado no International Prospective Register of Systematic Reviews (PROSPERO). As buscas foram realizadas na LILACS e na PubMed (setembro/2022). Foram incluídos estudos observacionais realizados com a população brasileira, publicados a partir de 2003, que: (1) analisam a associação da IA com DCNTs; e (2) utilizam a Escala Brasileira de Insegurança Alimentar (EBIA). Foram excluídos estudos com gestantes e que associam a IA com câncer, infecções sexualmente transmissíveis e doenças musculoesqueléticas e respiratórias. Os estudos foram submetidos à avaliação da qualidade metodológica. Resultados: Foram incluídos 27 estudos transversais, dentre os quais 9 utilizaram dados secundários de inquéritos nacionais e os demais utilizaram dados primários. Os estudos revelaram associação da IA com sobrepeso e obesidade em diferentes faixas etárias. Conclusão: Os artigos incluídos não produziram evidências sobre outras DCNTs de interesse para a saúde no Brasil, como a diabetes e a hipertensão arterial. No entanto, contribuem para corroborar a relação já conhecida entre obesidade e IA. Estudos sobre a temática, com desenho longitudinal, devem ser incentivados.

Resumen: El objetivo fue describir las acciones de vigilancia y seguridad de la vacuna contra mpox (Jynneos) en Brasil, del 2022 al 2023. Se realizó un estudio descriptivo de los casos de mpox y de los eventos supuestamente atribuibles a la vacunación o inmunización para la vacuna Jynneos, registrados en los sistemas de información. Se calcularon frecuencias absolutas y relativas y coeficientes de notificación de eventos supuestamente atribuibles a la vacunación o inmunización por 1.000 dosis administradas. Se registraron 9.596 casos de mpox y se distribuyeron 49.000 dosis de vacuna, de estas se administraron 14.395 (31%) dosis y se reportaron 65 eventos supuestamente atribuibles a la vacunación o inmunización (4,5 por 1.000 dosis administradas). Todos los eventos supuestamente atribuibles a la vacunación o inmunización no fueron graves y 22 (33,8%) casos tuvieron reacciones relacionadas con el producto. Los resultados son acordes a la frecuencia esperada. Sin embargo, puede que el número de dosis administradas no haya sido suficiente para detectar eventos raros o inusuales. Por lo tanto, es necesaria una vigilancia continua para garantizar la eficacia y la seguridad de la vacunación, especialmente entre los grupos con mayor riesgo de contraer la enfermedad.

Abstract: This study describes the surveillance and safety actions of the mpox (Jynneos) vaccine in Brazil, from 2022 to 2023. A descriptive study of mpox cases and events supposedly attributable to vaccination and/or immunization for Jynneos vaccine, recorded in the information systems, was conducted. Absolute and relative frequencies and reporting coefficients of events supposedly attributable to vaccination and/or immunization per 1,000 administered doses were calculated. A total of 9,596 cases of mpox were registered and 49,000 doses of vaccine were distributed, of which 14,395 (31%) were administered and 65 events supposedly attributable to vaccination and/or immunization (4.5 per 1,000 administered doses) were notified. All events supposedly attributable to vaccination and/or immunization were non-serious, and 22 (33.8%) cases had product-related reactions. Results are within the expected frequency; however, the number of administered doses may not have been sufficient to detect rare or unusual events. Continued surveillance is necessary to ensure vaccination effectiveness and safety, especially among groups at higher risk for the disease.

Resumo: O objetivo deste estudo é descrever as ações de vigilância e segurança da vacina contra a mpox (Jynneos) no Brasil, de 2022 a 2023. Realizou-se estudo descritivo dos casos de mpox e dos eventos supostamente atribuíveis à vacinação e/ou imunização para vacina Jynneos, registrados nos sistemas de informação. Foram calculadas frequências absolutas e relativas e coeficientes de notificação de eventos supostamente atribuíveis à vacinação e/ou imunização por mil doses administradas. Foram registrados 9.596 casos de mpox e distribuídas 49 mil doses de vacina; dessas, 14.395 (31%) doses foram administradas e 65 eventos supostamente atribuíveis à vacinação e/ou imunização (4,5 por mil doses administradas) foram notificados. Todos os eventos supostamente atribuíveis à vacinação e/ou imunização foram não graves e 22 (33,8%) casos apresentaram reações relacionadas ao produto. Os resultados estão dentro da frequência esperada. No entanto, o número de doses administradas pode não ter sido suficiente para detectar eventos raros ou inusitados. Portanto, a vigilância contínua é necessária para garantir a efetividade e a segurança da vacinação, especialmente entre os grupos de maior risco.

RESUMO Objetivo Apresentar a etapa da evidência de validade baseada nos processos de respostas do Protocolo MMBGR Lactentes e Pré-escolares: Instrutivo e História Clínica Miofuncional Orofacial. Método Estudo desenvolvido conforme recomendações para validação de testes em Fonoaudiologia. Realizada análise da validade baseada nos processos de resposta do instrumento. Participaram dez fonoaudiólogos, que atuam em clínica e/ou pesquisa da Motricidade Orofacial com população entre 6 e 71 meses de idade, que aplicaram o Protocolo MMBGR Lactentes e Pré-escolares: Instrutivo e História Clínica Miofuncional Orofacial junto aos responsáveis pelas crianças. Os fonoaudiólogos emitiram apreciação sobre aplicabilidade do instrumento via formulário eletrônico do Google®, contendo questões dicóticas e/ou múltipla escolha, e escala likert com espaço para justificar respostas negativas. Os dados foram tabulados em planilhas Microsoft Excel 2016® e analisados pelo Índice de Validade de Conteúdo (IVC). Utilizado software R Core Team 2022 (Versão 4.2.2). Resultados Todos os itens do Protocolo MMBGR Lactentes e Pré-escolares: Instrutivo e História Clínica Miofuncional Orofacial foram válidos na aplicação em contexto real. Protocolo de História Clínica Miofuncional Orofacial - IVC 100% quanto à facilidade de aplicação e preenchimento, e uso na prática profissional; e IVC 90% quanto à utilidade para clínica fonoaudiológica. O Instrutivo obteve IVC 80% quanto à utilidade e 70% referente à necessidade de leitura prévia para preenchimento do Protocolo MMBGR Lactentes e Pré-escolares. Conclusão O Instrutivo e o Protocolo História Clínica Miofuncional Orofacial, pertencentes ao protocolo MMBGR – Lactentes e Pré-escolares tiveram comprovada validade baseada nos processos de resposta, para uso na clínica fonoaudiológica. Préescolares Pré escolares Fonoaudiologia eou ou 7 idade crianças Google Google® escolha negativas 2016 IVC. . (IVC) 202 Versão 4.2.2. 422 4.2.2 4 2 4.2.2) real 100 profissional 90 fonoaudiológica 80 70 Préescolares. escolares. 201 (IVC 20 42 4.2. 10 9 8 4.2 1 4.

ABSTRACT Purpose Present the step of evidence of validity based on the responses to procedures of the MMBGR Protocol Infants and Preschoolers: Instructional and Orofacial Myofunctional Clinical History. Methods Study developed according to phonoaudiologic tests validations recommendations. Validity analysis performed based on the process of instrument response. Ten speech therapists, that work on phonoaudiology clinic and/or orofacial myofunctional research on the population with age between 6 to 71 months, participated and applied the MMBGR Protocol Infants and Preschoolers: Instructional and Orofacial Myofunctional Clinical History with those responsible for the children. The speech therapists appraised the instrument applicability via Google®️ electronic forms, containing dichotic and/or multiple-choice questions, and likert scale with space to justify negative answers. The data was tabulated on Microsoft Excel 2016®️ worksheets and analyzed by the content validity index (CVI). The software R Core Team 2022 (Versão 4.2.2) was used. Results All items from the MMBGR Protocol Infants and Preschoolers: Instructional and Orofacial Myofunctional Clinical History were valid when applied to real contexts. Orofacial Myofunctional Clinic history protocol- IVC 100% in terms of ease of application and filling and usage in professional practice; IVC 90% in terms of usefulness for phonoaudiology clinic. The instructional got IVC 80% in terms of clinic usefulness and 70% regarding to the prior reading necessity to fill the MMBGR Protocol Infants and Preschoolers. Conclusion The Instrucional and Orofacial Myofunctional Clinical History, in the MMBGR Protocol Infants and Preschoolers had its validity proven based on the processes of responses to the usage on phonoaudiology clinic. recommendations response andor or 7 months children Google Google® forms multiplechoice multiple choice questions answers 2016 2016® CVI. CVI . (CVI) 202 Versão 4.2.2 422 4 2 used contexts protocol 100 practice 90 80 70 201 (CVI 20 4.2. 42 10 9 8 4.2 1 4.

Resumo O objetivo do estudo foi mapear os aspectos relacionados à gestão de programas de residência em saúde considerando todos os atores envolvidos. Trata-se de uma revisão de escopo adotando as diretrizes estabelecidas pelo JBI. Foram utilizadas como fontes de informação LILACS, MEDLINE, via PubMed, SCOPUS, EMBASE, CINAHL with Full Text e Fonte Acadêmica/EBSCO e Web of Science, entre outras descritas na seção método. Com a estratégia de busca, identificaram-se 17.114 documentos, e após o processo de análise, que envolveu remoção de duplicatas, leitura de título, resumo e textos completos, 32 documentos foram incluídos na revisão, por estarem relacionados à gestão de programas de residência em saúde. A partir do mapeamento desses documentos, surgiram categorias que estavam relacionadas aos aspectos de gestão elencados nesta pesquisa. Algumas informações encontradas se destacaram. Na gestão de pessoas, observam-se aspectos relacionados a recrutamento, seleção dos residentes e treinamento de preceptores. Já na organização, destacam-se estruturação e possibilidades de reorganização de comunicação do programa de residência, bem como os desafios na organização de atividades.

Resumen Este estudio tuvo como objetivo mapear aspectos relacionados a la gestión de Programas de Residencia en Salud, considerando todos los actores involucrados. Esta revisión de alcance adoptó los lineamientos establecidos por el JBI. Se utilizaron como fuentes de información LILACS, MEDLINE, vía PubMed, SCOPUS, EMBASE, CINAHL with Full Text y Academic Source/EBSCO, Web of Science, entre otras descritas en la sección de método. La estrategia de búsqueda identificó 17.114 documentos. Luego del proceso de análisis, que implicó eliminar duplicados, lectura de título, resumen y textos completos, se incluyeron en la revisión 32 documentos, por estar relacionados con la gestión de Programas de Residencia en Salud. Del mapeo de estos documentos surgieron categorías que estaban relacionadas con los aspectos de gestión enumerados en esta investigación. Se destacaron algunas informaciones. En la gestión de personas, se observaron aspectos relacionados con el reclutamiento, la selección de residentes, y la formación de preceptores. Respecto a la organización, destacamos la estructuración y posibilidades de reorganizar la comunicación del Programa de Residencia, así como los desafíos en la preparación de actividades.

Abstract This scoping review aimed to comprehensively map various facets of managing Health Residency Programs, considering all actors and adopting the guidelines established by the JBI. Databases comprised LILACS and MEDLINE via PubMed, SCOPUS, EMBASE, CINAHL with full text, academic source or EBSCO, and Web of Science, among others. A total of 17,114 documents were identified, with 32 articles related to the management of Health Residency Programs included after duplicate removal and title, abstract, and full article reading. The management categories listed in this study resulted from mapping the analyzed articles. Highlighted aspects of people management include recruitment, resident selection, and preceptor training. Regarding organization, the emphasized aspects encompass structuring and reorganizing communication within the residency program and challenges associated with organizing activities.

Abstract Objective To evaluate the effect of oropharyngeal colostrum immunotherapy (OCI) on the mortality of preterm newborns (PTNB) with very low birth weight (VLBW). Method Non-randomized clinical trial, carried out with 138 mother-child pairs attended at a public maternity hospital. The treatment group used raw colostrum, dripping 4 drops (0.2 ml) into the oropharyngeal mucosa, totaling 8 administrations in 24 h, up to the 7th complete day of life (OCI). The control group was composed of newborns admitted to the same maternity hospital before the implementation of the OCI. Analyzes were performed: descriptive, bivariate, multiple logistic regression, and survival analysis, with a significance level of 5% and 95% CI. Results The treatment group had an RR of death of 0.26 (95% CI = 0.07-0.67; p= 0.00), adjusted for maternal age, marital status, gestational hypertension, type of delivery, number of prenatal visits, and birth weight. Number Needed to Treat (NNT) demonstrated that for every 5 individuals treated with OCI, one death was prevented NNT = 4.9 (95% CI = 1.84-5.20); however, for PTNB with VLBW who remained hospitalized for 50, 100 and 150 days, the NNT reduces to 4, 4 and 3, respectively. Conclusion The OCI proved to be a beneficial intervention, since it reduced the risk of mortality in PTNB with VLBW when compared to the control group. (OCI (PTNB VLBW. . (VLBW) Nonrandomized Non randomized trial 13 motherchild mother child 0.2 02 0 2 (0. ml mucosa h th performed descriptive bivariate regression analysis 95 026 26 (95 0.070.67 007067 0.07 0.67 07 67 0.07-0.67 p 0.00, 000 0.00 , 00 0.00) age status hypertension delivery visits (NNT 49 9 4. 1.845.20 184520 1.84 5.20 1 84 20 1.84-5.20) however 50 10 15 days 3 respectively intervention (VLBW 0. (0 (9 070 0.070.6 00706 007 0.0 067 0.6 6 0.07-0.6 845 1.845.2 18452 184 1.8 520 5.2 1.84-5.20 ( 0.070. 0070 06 0.07-0. 1.845. 1845 18 1. 52 5. 1.84-5.2 0.070 0.07-0 1.845 1.84-5. 0.07- 1.84-5 1.84-

Resumo Objetivos: avaliar o efeito da imunoterapia orofaríngea de colostro no tempo de internamento hospitalar de recém-nascidos pré-termos de muito baixo peso. Métodos: estudo de intervenção, ambispectivo, que consistiu em oito administrações diárias de 0,2 ml (quatro gotas) de colostro, totalizando até 56 seringas (por até sete dias). O controle foi histórico. A variável independente principal: tempo de permanência hospitalar (dias). Realizada análise de sobrevivência pelo Método de Kaplan-Meier e estimado o efeito da sobrevida - Teste de Log Rank (Mantel-Cox) e Teste de Breslow (Wilcoxon Generalizado). Adotou-se o nível de significância de 5%. Resultados: das 109 duplas mães/filho, 56 fizeram parte da análise do grupo tratamento e 53 do controle. Não houve associação entre imunoterapia orofaríngea de colostro e tempo de internamento de recém-nascidos pré-termos de muito baixo peso na amostra geral. Após estratificação demonstrou-se menor tempo de permanência hospitalar (43 versus 51 dias, HR=1,78, IC95%= 1,02-3,09, p=0,04) entre os prematuros com ≥28 semanas gestacionais submetidos a imunoterapia orofaríngea de colostro. Conclusões: encontrou-se associação entre imunoterapia orofaríngea de colostro e menor mediana de tempo de internamento hospitalar no subgrupo de prematuros ≥ 28 semanas de idade gestacional, porém não foram encontradas diferenças significativas naqueles < 28 semanas. Objetivos recémnascidos recém nascidos prétermos pré termos Métodos intervenção ambispectivo 02 0 2 0, quatro gotas 5 por dias. dias . dias) histórico principal (dias) KaplanMeier Kaplan Meier MantelCox Mantel Cox (Mantel-Cox Wilcoxon Generalizado. Generalizado Generalizado) Adotouse Adotou se 5% Resultados 10 mãesfilho mães filho mães/filho geral demonstrouse demonstrou 43 (4 HR178 HR 1 78 HR=1,78 IC95 IC IC95% 1,023,09, 102309 1,02 3,09, 3 09 1,02-3,09 p=0,04 p004 p 04 ≥2 Conclusões encontrouse encontrou gestacional (dias 4 ( HR17 7 HR=1,7 IC9 023 1,023,09 10230 102 1,0 309 3,09 1,02-3,0 p=0,0 p00 HR1 HR=1, 1,023,0 1023 1, 30 3,0 1,02-3, p=0, p0 HR=1 1,023, 3, 1,02-3 p=0 HR= 1,023 1,02- p=

Abstract Objectives: to evaluate the effect of oropharyngeal colostrum immunotherapy on the length of hospital stay in preterm newborns with very low birth weight. Methods: interventional ambispective study, which consisted of eight daily administrations of 0.2 ml (four drops) of colostrum, totaling up to 56 syringes (for up to seven days). The control was historic. The main independent variable: length of hospital stay (days). Survival analysis was performed using the Kaplan-Meier Method and the survival effect was estimated - Log Rank Test (Mantel-Cox) and Breslow Test (Generalized Wilcoxon). A significance level of 5% was adopted. Results: of the 109 mother/child pairs, 56 were part of the treatment and 53 were part of the control group. There was no association between oropharyngeal colostrum immunotherapy and length of stay for preterm newborns with very low birth weight in the general sample. However, after stratification, a shorter hospital stay (42 versus 51 days, HR= 1.78, CI95%=1.02-3.09, p=0.04) was demonstrated among premature infants with ≥28 gestational weeks undergoing oropharyngeal colostrum immunotherapy. Conclusions: we found an association between oropharyngeal colostrum immunotherapy and shorter median length of hospital stay in the subgroup of premature infants ≥ 28 weeks of gestational age, but we did not find significant differences in those <28 weeks. Objectives Methods study 02 0 2 0. four drops 5 days. days . days) historic variable (days) KaplanMeier Kaplan Meier MantelCox Mantel Cox (Mantel-Cox Generalized Wilcoxon. Wilcoxon Wilcoxon) adopted Results 10 motherchild mother child pairs group sample However stratification 42 (4 HR 178 1 78 1.78 CI95%=1.023.09, CI95102309 CI CI95%=1.02 3.09, CI95 3 09 CI95%=1.02-3.09 p=0.04 p004 p 04 ≥2 Conclusions age <2 (days 4 ( 17 7 1.7 023 CI95%=1.023.09 CI9510230 CI95102 CI95%=1.0 309 3.09 CI9 CI95%=1.02-3.0 p=0.0 p00 < 1. CI95%=1.023.0 CI951023 CI9510 CI95%=1. 30 3.0 CI95%=1.02-3. p=0. p0 CI95%=1.023. CI951 CI95%=1 3. CI95%=1.02-3 p=0 CI95%=1.023 CI95%= CI95%=1.02- p= CI95%

ABSTRACT Objective: To evaluate the prevalence of sharps accidents among dental students in southwest Goiás state, Brazil, and further survey their knowledge of biosafety and post-injury management. Material and Methods: A cross-sectional analytical observational study was carried out in 2018 following the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) guidelines. The study population included dental students in the 4th and 10th course semester. A pre-formulated self-administered questionnaire containing 14 objective questions was used for data collection. Mean and standard deviation values were calculated. Results: A total of 308 responses were obtained. Overall, 15.9% of the respondents reported having previously experienced accidents with sharps. Most dental students who claimed to know the biological risks to which they are exposed were in the 5th and 8th course semesters, and 67.2% of them reported knowing how to proceed in the event of a sharp accident. Conclusion: A low prevalence of sharps accidents has been reported, and dental students are considered to have a good knowledge of biosafety. Objective state Brazil postinjury post injury management Methods crosssectional cross sectional 201 STROBE (STROBE guidelines th semester preformulated pre formulated selfadministered self administered 1 collection calculated Results 30 obtained Overall 159 15 9 15.9 semesters 672 67 2 67.2 accident Conclusion 20 3 15. 6 67.

Abstract The objective of the current study was to carry out a survey of the main anatomopathological alterations in raising quails and evaluate possible interference of these in the bone tissue. To obtain the data, 23 quails were collected from farm in the central Serrana region of Espírito Santo. Necropsies with macroscopic descriptions, microbiological, coproparasitological, radiographic and histomorphometric tests were carried out. It was done data descriptive analysis and average comparision using Student T test. It was found that they presented lesions predominantly in the digestive system, followed by urinary and reproductive, and muscular system, were the altered color of the liver (47%) was the most frequent lesion. In the parasitological exams, it was found oocysts of Eimeira sp. (39.13%). In the microbiological exams, it was detected predominantly Escherichia coli (83%). Moderate osteopenia in quails, but the percentage of trabecular bone on bones was similar between healthy and diseased quails, without bone changes in histology. Microscopically, it was observed lung congestion as predominant lesion. It is concluded that there was predominance of alterations in the digestive system and mild parasitic infection; and although there was moderate level of osteopenia, there wasn’t bone change as a result of the observed infections. tissue 2 Santo descriptions coproparasitological test reproductive 47% 47 (47% lesion exams sp 39.13%. 3913 39.13% . 39 13 (39.13%) 83%. 83 83% (83%) histology Microscopically infection wasnt wasn t infections 4 (47 391 39.13 3 1 (39.13% 8 (83% (4 39.1 (39.13 (83 ( 39. (39.1 (8 (39. (39 (3

RESUMO. Dada a importância da síndrome demencial e de seus impactos na população, cresce o interesse em estudar os fatores de risco modificáveis para a demência. Objetivo: Comparar a prevalência de fatores de risco para demência em adultos de meia-idade e pessoas idosas, em um período de dois anos, e identificar quais fatores de risco na avaliação de base predizem o declínio cognitivo na avaliação de acompanhamento. Métodos: Estudo longitudinal e quantitativo, com avaliação de acompanhamento após dois anos, realizado com 200 participantes com 45 anos ou mais, cadastrados na Atenção Básica. Nas avaliações de base (2018/2019) e de acompanhamento (2021) foram coletados dados sociodemográficos, foram feitas avaliação cognitiva e avaliação dos fatores de risco para demência (escolaridade, perda auditiva, traumatismo craniano, hipertensão arterial, uso de álcool, obesidade, tabagismo, sintomas depressivos, isolamento social, inatividade física, diabetes mellitus). Os dados foram comparados pelo teste de McNemar. Modelos de regressão logística multinominal individuais foram conduzidos para identificar quais fatores estavam associados ao declínio cognitivo após dois anos. Resultados: Os percentuais de baixa escolaridade, traumatismo craniano e tabagismo mantiveram-se os mesmos nas duas avaliações. Houve aumento significativo da prevalência de hipertensão arterial (de 55,0 para 62,0%) e inatividade física (de 58,5 para 74,5%), e redução significativa do isolamento social (de 25,5 para 18,0%). Participantes com sintomas depressivos na avaliação de base apresentaram maior risco de declínio cognitivo no acompanhamento. Conclusão: Houve aumento das prevalências de hipertensão arterial e inatividade física; e redução do isolamento social. Sintomas depressivos predizem declínio cognitivo. RESUMO população Objetivo meiaidade meia idade idosas Métodos quantitativo 20 4 mais Básica 2018/2019 20182019 2018 2019 (2018/2019 2021 (2021 sociodemográficos escolaridade (escolaridade auditiva álcool obesidade mellitus. mellitus . mellitus) McNemar Resultados mantiveramse mantiveram se 550 55 0 55, 62,0% 620 62 585 58 5 58, 74,5%, 745 74,5% , 74 74,5%) 255 25 25, 18,0%. 180 18,0% 18 18,0%) Conclusão 2 2018/201 2018201 201 (2018/201 202 (202 62,0 6 74,5 7 18,0 1 2018/20 201820 (2018/20 (20 62, 74, 18, 2018/2 20182 (2018/2 (2 2018/ (2018/ ( (2018 (201

ABSTRACT. Given the importance of dementia syndrome and its impacts on the population, interest in studying modifiable risk factors for dementia is growing. Objective: To compare the prevalence of risk factors for dementia in middle-aged and older adults over a two-year period and to identify what variables in baseline were predictive of cognitive decline in the follow-up. Methods: Longitudinal and quantitative study, with follow-up evaluation after two years, conducted with 200 participants aged 45 years or more, registered in Primary Care Units. In the baseline (2018/2019) and follow-up (2021) assessments, sociodemographic data were collected, and cognitive performance and risk factors for dementia were evaluated (education, hearing loss, head trauma, high blood pressure, alcohol use, obesity, smoking, depressive symptoms, social isolation, physical inactivity, and diabetes mellitus). Data were compared using the McNemar’s test. Individual multinomial logistic regression models were performed to identify the factors associated with cognitive decline after two years. Results: The percentages of low education, traumatic brain injury, and smoking remained the same in both assessments. There was a significant increase in the prevalence of high blood pressure (from 55.0 to 62.0%) and physical inactivity (from 58.5 to 74.5%) and a significant reduction in social isolation (from 25.0 to 18.0%). Participants with depressive symptoms in baseline had a higher risk of cognitive decline in follow-up. Conclusion: There was an increase in the prevalence of high blood pressure and physical inactivity and a reduction in social isolation after two years. Depressive symptoms predict cognitive decline. ABSTRACT population growing Objective middleaged middle twoyear year followup. followup follow up. up Methods study 20 4 more Units 2018/2019 20182019 2018 2019 (2018/2019 2021 (2021 assessments collected education (education loss trauma use obesity mellitus. mellitus . mellitus) McNemars McNemar s test Results injury from 550 55 0 55. 62.0% 620 62 585 58 5 58. 74.5% 745 74 250 25 25. 18.0%. 180 18.0% 18 18.0%) Conclusion 2 2018/201 2018201 201 (2018/201 202 (202 62.0 6 74.5 7 18.0 1 2018/20 201820 (2018/20 (20 62. 74. 18. 2018/2 20182 (2018/2 (2 2018/ (2018/ ( (2018 (201