Capillary electrophoresis (CE) methods have unique potential for applications in quality control of pharmaceutical formulations. Here, we show that a single and ultra-fast CE method can be used for the determination of hydrochlorothiazide (HCT) in combination with nine other active ingredients in a single run in different pharmaceutical samples: atenolol (ATE), metoprolol (MET), propranolol (PRO), benazepril (BEN), captopril (CAP), enalapril (ENA), lisinopril (LIS), ramipril (RAM), and valsartan (VAL). This goal was achieved using a single and simple background electrolyte (BGE) composed of 10 mmol L-1 of boric acid with pH adjusted to 9.0 with sodium hydroxide. All samples can be analyzed in less than 1 min with the attainment of good analytical performance, such as high-resolution separation (r > 1.3), low sample and reagents consumption (environmentally friendly method), low relative standard deviation (RSD) values for peak area (< 4.0%) and migration times (< 1.7%), and linear relationships with good correlation coefficients (> 0.995). Furthermore, recovery tests showed good results (100 ± 5%) for all evaluated compounds. (CE formulations Here ultrafast ultra fast HCT (HCT ATE, ATE , (ATE) MET, MET (MET) PRO, PRO (PRO) BEN, BEN (BEN) CAP, CAP (CAP) ENA, ENA (ENA) LIS, LIS (LIS) RAM, RAM (RAM) VAL. VAL . (VAL) BGE (BGE L1 L L- 90 9 0 9. hydroxide performance highresolution high resolution r 1.3, 13 1.3 3 1.3) environmentally method, method) RSD (RSD < ( 4.0% 40 4 1.7%, 17 1.7% 7 1.7%) 0.995. 0995 0.995 995 0.995) Furthermore 100 (10 5% 5 compounds (ATE (MET (PRO (BEN (CAP (ENA (LIS (RAM (VAL 1. 4.0 1.7 099 0.99 99 (1 4. 09 0.9 0.

Losartan potassium and hydrochlorothiazide are often combined in pharmaceutical formulations for the treatment of hypertension. Therefore, the determination of these compounds in a single run is highly desirable for rapid quality control applications. The present study describes an ultra-fast (ca. 85 injections h-1) and environmentally friendly method based on capillary electrophoresis (CE) with capacitively coupled contactless conductivity detection for simultaneous quantification of potassium, losartan and hydrochlorothiazide. Cation (potassium) and anions (losartan and hydrochlorothiazide) were analyzed in a single run using a background electrolyte composed by 10.0 mmol L-1 boric acid (pH = 9.0, adjusted with sodium hydroxide). The limits of detection were 4.0, 3.0 and 10.0 μmol L-1 for potassium, losartan and hydrochlorothiazide, respectively. The proposed method is simple, fast, with minimal waste generation, and accurate (recovery values between 98 and 102%). The results obtained with the CE method were statistically similar (95% confidence level) to those obtained by high-performance liquid chromatography (losartan and hydrochlorothiazide) and flame photometry (potassium). hypertension Therefore applications ultrafast ultra fast ca. ca (ca 8 h1 h 1 h-1 (CE (potassium 100 10 0 10. L1 L L- pH 90 9 9.0 hydroxide. hydroxide . hydroxide) 40 4 4.0 30 3 3. respectively simple generation recovery 102%. 102 102% 102%) 95% 95 (95 level highperformance high performance potassium. h- 9. 4. (9 (

This paper presents a simple and low-cost capillary electrophoresis method for ultra-fast simultaneous determination of naphazoline (NPZ) and one of the following active ingredients: diphenhydramine (DIP), pheniramine (PHEN) or chlorpheniramine (CPHEN). The proposed method is based on capillary electrophoresis with capacitively coupled contactless conductivity detection (CE-C4D) equipped with a short length capillary column (10 cm). One sample can be analyzed every 35 s (ca. 100 injections per hour) with resolutions between peaks greater than 1.4. The optimized background electrolyte (BGE) was composed by 20 mmol L-1 histidine and 10 mmol L-1 3,4-dimethoxycinnamic acid (pH = 9.5, adjusted with NaOH). Limits of detection were 25 µmol L-1 for NPZ, DIP, and PHEN and 13 µmol L-1 for CPHEN. The results obtained with the developed procedure were compared to those obtained by high-performance liquid chromatography (HPLC) and no statistically significant differences were observed (95% confidence level).

In this paper, we present a simple and low-cost capillary electrophoresis method for ultra-fast determination of active ingredients present in three different pharmaceutical formulations: (i) scopolamine (SCO) and dipyrone (DIP); (ii) orphenadrine (ORP), caffeine (CAF) and DIP; (iii) mepyramine (MEP), CAF, DIP, and ascorbic acid (AA). The proposed method is based on capillary electrophoresis with capacitively coupled contactless conductivity detection (CE-C4D). The samples can be analyzed in a single run (< 1 minute) using 10 mmol L-1 3,4-dimethoxycinnamate (DMX) and 12 mmol L-1 triethanolamine (TEA) as a background electrolyte (pH = 8.5). A linear working range (r > 0.993) was obtained from 0.10 to 0.50 mmol L-1 for SCO, from 0.25 to 1.25 mmol L-1 for ORP and MEP, from 0.50 to 2.50 mmol L-1 for DIP and CAF, and from 1.00 to 3.00 mmol L-1 for AA. The limits of detection were 0.02, 0.05, 0.03, 0.04, 0.02, and 0.06 mmol L-1 for SCO, DIP, ORP, CAF, MEP, and AA, respectively. In addition, the proposed method also provided adequate intra (< 4%) and inter-day (< 14%) precision values, as well as satisfactory recovery values for spiked pharmaceutical samples (from 92% to 103%).